Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| confirmed case of feline mycetoma due to microsporum canis. | the first case of feline true mycetoma because of a dermatophyte has been reported in this manuscript, although pseudomycetoma has been described in dogs and cats. the patient was a 9-year-old castrated male persian cat weighing 4.2 kg with subcutaneous nodules on the dorsal trunk. physical examination revealed two subcutaneous nodules (2.5 x 5.0 cm and 3.5 x 5.0 cm in size) that drained purulent exudates with cement-like substances containing yellowish granules. the impression smear of the yell ... | 2009 | 18444972 |
| the significance of itraconazole for treatment of fungal infections of skin, nails and mucous membranes. | itraconazole is an antifungal drug from the triazole group with distinct in vitro activity against dermatophytes, yeasts and some molds. itraconazole has a primarily fungistatic activity. itraconazole accumulates in the stratum corneum and in nail material due to its high affinity to keratin, as well as in sebum and vaginal mucosa. together with terbinafine and fluconazole, itraconazole belongs to the modern highly effective systemic antifungal drugs with a favorable risk-benefit ratio and for t ... | 2009 | 18479501 |
| synthesis of organometallic-based biologically active compounds: in vitro antibacterial, antifungal and cytotoxic properties of some sulfonamide incorporated ferrocences. | sulfonamides incorporated ferrocene (sif) have been synthesized by the condensation reaction of sulfonamides (sulfanilamide, sulfathiazole or sulfamethaxazole) with 1,1'-diacetylferrocene. the synthesized compounds (sif(1)-sif(4)) have been characterized by their physical, spectral and analytical properties and have been screened for their in vitro antibacterial properties against pathogenic bacterial strains e.g., escherichia coli, pseudomonas aeruginosa, bacillus subtilis staphylococcus aureus ... | 2009 | 18608785 |
| a lufenuron pre-treatment may enhance the effects of enilconazole or griseofulvin in feline dermatophytosis? | the effectiveness of enilconazole (4 weekly rinses with a 0.2% solution) or griseofulvin (50mg/kg twice daily for 40 days) following a pre-treatment with oral lufenuron (100mg/kg by-weekly for 8 weeks) was tested on 25 (11+14) microsporum canis infected cats. control animals were treated with lufenuron, griseofulvin and enilconazole alone. at day 150 pre-treated animals were culturally negative and clinically cured. while lufenuron alone was found to be ineffective against m canis infection, an ... | 2009 | 18684653 |
| pets as the main source of two zoonotic species of the trichophyton mentagrophytes complex in switzerland, arthroderma vanbreuseghemii and arthroderma benhamiae. | in cases of highly inflammatory dermatophytosis in humans, it is important to identify the possible source of animal transmission in order to prevent recurrence, family outbreaks or rapidly progressing epidemics. a survey of dermatophytes in pets during a 14-month period in switzerland revealed, in addition to microsporum canis, two different species of the trichophyton mentagrophytes complex, arthroderma benhamiae and arthroderma vanbreuseghemii, all causing inflammatory dermatophytoses. arthro ... | 2009 | 18699813 |
| design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. | this study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome p450 14alpha-demethylase (14dm). the chemical structures of the new compounds were confirmed by elemental and spectral ((1)h nmr, (13)c nmr, mass) analyses. compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. furthermore, they were found to have in vitro activity against microsporum c ... | 2009 | 18760508 |
| tinea capitis in southwest poland. | tinea capitis in southwest poland is mainly caused by zoophilic dermatophytes. microsporum canis is the main pathogen, which was demonstrated in all analysed periods between 1977 and 2006 (50.5%-63.2%). recently (2002-2006), a significant (p < 0.05) increase of trichophyton tonsurans isolates was observed, which may be due to increasing migration of polish population in this period. to sum up, the data on the prevalence of tinea capitis in southwest poland resemble the epidemiological situation ... | 2009 | 18793266 |
| antibacterial, antifungal, insecticidal, cytotoxicity and phytotoxicity studies on indigofera gerardiana. | the antibacterial, antifungal, acute cytotoxicity, phytotoxicity and insecticidal profile of the crude extract and various fractions of indigofera gerardiana have been studied. six bacterial and fungal strains were used, of which samonella typhi and microsporum canis were the most susceptible strains with mics 0.37 mg/ml and 0.09 mg/ml, respectively. the crude extract and the fractions showed low insecticidal activity against sitophilus oryzae, rhyzopertha dominica and callosbruchus analis but n ... | 2009 | 18825532 |
| metal based isatin-derived sulfonamides: their synthesis, characterization, coordination behavior and biological activity. | some isatin derived sulfonamides and their transition metal [co(ii), cu(ii), ni(ii), zn(ii)] complexes have been synthesized and characterized. the structure of synthesized compounds and their nature of bonding have been inferred on the basis of their physical (magnetic susceptibility and conductivity measurements), analytical (elemental analyses) and spectral (ir, (1)h nmr and (13)c nmr) properties. an octahedral geometry has been suggested for co(ii), ni(ii) and zn(ii) and square-planar for cu ... | 2009 | 18825557 |
| dermatophyte infections in cairo, egypt. | in this study, we examined dermatophyte infections in patients referred to the department of dermatology, el-houd el-marsoud hospital, cairo, during march 2004 to june 2005. of 506 patients enrolled in this investigation, 403 (79.6%) were clinically diagnosed as having dermatophytoses (age range 6-70 years; males 240; females 163). species identification determined by observation of their macroscopic and microscopic characteristics was complemented with sequencing of the internal transcribed spa ... | 2009 | 18972221 |
| secreted dipeptidyl peptidases as potential virulence factors for microsporum canis. | dermatophytoses caused by microsporum canis are frequently encountered in cats and dogs; they are highly contagious and readily transmissible to humans. in this study, two single genes, respectively coding for dipeptidyl peptidases iv and v (dppiv and dppv), were isolated and characterized. both proteins share homology with serine proteases of the s9 family, some of which display properties compatible with implication in pathogenic processes. both genes are expressed in vivo in experimentally in ... | 2008 | 19049642 |
| antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole. | commercially available topical formulations consisting of iodoquinol 1%-hydrocortisone acetate 2%, ciclopirox 0.77%, and clotrimazole 1%-betamethasone dipropionate 0.5% were assessed for their antimicrobial activity against cultures of micrococcus luteus, propionibacterium acnes, methicillin-resistant staphylococcus aureus (mrsa), pseudomonas aeruginosa, corynebacterium aquaticum, trichophyton mentagrophytes, malassezia furfur, microsporum canis, candida albicans, trichophyton rubrum, or epiderm ... | 2008 | 19055171 |
| successful resolution of dermatophyte mycetoma following terbinafine treatment in two cats. | microsporum canis sensitive to itraconazole and terbinafine was isolated from two cats presented with generalized dermatophytosis and dermatophyte mycetoma. itraconazole therapy was withdrawn through lack of efficacy in one cat (a persian) and unacceptable adverse effects in the other (a maine coon). both cats achieved clinical and mycological cure after 12-14 weeks therapy with 26-31 mg kg(-1) terbinafine every 24 h per os (po). clinical signs in the maine coon resolved completely after 7 weeks ... | 2008 | 19055614 |
| in vitro anti-microbial activity of the cuban medicinal plants simarouba glauca dc, melaleuca leucadendron l and artemisia absinthium l. | in the present study, an extensive in vitro antimicrobial profiling was performed for three medicinal plants grown in cuba, namely simarouba glauca, melaleuca leucadendron and artemisia absinthium. ethanol extracts were tested for their antiprotozoal potential against trypanosoma b. brucei, trypanosoma cruzi, leishmania infantum and plasmodium falciparum. antifungal activities were evaluated against microsporum canis and candida albicans whereas escherichia coli and staphylococcus aureus were us ... | 2008 | 18949336 |
| infectious alopecia in a dog breeder after renal transplantation. | tinea capitis rarely occurs in renal transplant recipients. we report this living-related renal transplant patient receiving cyclosporine-based therapy who initially presented with severe exfoliation of the scalp with yellowish-white scales and marked hair loss. the lesions extended to the frontal area and both cheeks, resulting in several skin ulcers with perifocal erythematous inflammatory changes, and palpable cervical lymph nodes. a biopsy of a skin lesion revealed fungal infection and cultu ... | 2008 | 18818142 |
| [antagonistic activity of bacteria from bacillus genus against dermatophyte fungi]. | antagonistic properties of the strain bacillus subtilis ib-54 with respect to dermatophyte fungi trichophyton rubrum, t. mentagrophytes var. gypseum, microsporum canis was studied. the studied strains of bacilli effectively inhibited growth and development of dermatophytes when were cultivated on the media containing different carbon sources. experiments on laboratory animals showed that b. subtilis ib-54 displayed no virulence, toxicity, and toxigenicity and can be considered as perspective obj ... | 2008 | 18819402 |
| pramiconazole, a triazole compound for the treatment of fungal infections. | pramiconazole from barrier therapeutics inc is a new addition to the family of triazole antifungal agents that act by inhibiting fungal cell membrane ergosterol synthesis, thereby leading to increased cell permeability and destruction. barrier therapeutics was developing an oral formulation of pramiconazole for the potential treatment of seborrheic dermatitis (erythematosquamous skin disease), onychomycosis and dermatomycosis (including tinea versicolor, tinea pedis and tinea cruris/corporis). i ... | 2008 | 18763217 |
| biological activity of two related triterpenes isolated from combretum nelsonii (combretaceae) leaves. | antifungal bioassay-guided fractionation of combretum nelsonii leaf extracts afforded two closely related triterpenes, asiatic acid and arjunolic acid. antifungal activities of the mixture of asiatic acid and arjunolic acid were determined against five fungal animal pathogens. the minimum inhibitory concentrations of the mixture to the different pathogens varied from 0.2 to 1.6 microg ml(-1); candida albicans (0.9 microg ml(-1)), cryptococcus neoformans (0.4 microg ml(-1)), aspergillus fumigatus ... | 2008 | 18780249 |
| [synergy between ajoene and ketoconazole in isolates of microsporum canis. a preliminary study using fractional inhibitory concentration technique (fic)]. | fungal infections are probably the most frequent infectious diseases affecting human being. resistance to different anti-fungal drugs, and their bioavailability in the infection site, represent a problem for treatment. looking for effective solutions, combination of two or more antifungal drugs to obtain an additive effect or synergic effect that potent antifungal activity has been investigated. in this study, the effect (additive, antagonist or synergistic) of ajoene and ketoconazole combinatio ... | 2008 | 18785785 |
| secreted subtilisins of microsporum canis are involved in adherence of arthroconidia to feline corneocytes. | microsporum canis is a pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis, mainly in cats and humans. the mechanisms involved in adherence of m. canis to epidermis have never been investigated. here, a model was developed to study the adherence of m. canis to feline corneocytes through the use of a reconstructed interfollicular feline epidermis (rfe). in this model, adherence of arthroconidia to rfe was found to be time-dependent, starting at 2 h post-inoculat ... | 2008 | 18719187 |
| in vitro activity of cay-1, a saponin from capsicum frutescens, against microsporum and trichophyton species. | dermatomycoses are among the world's most common diseases and their incidence has increased over recent years, particularly in immunosuppressed patients. in previous studies, the saponin cay-1 from cayenne pepper (capsicum frutescens), has shown antifungal activities against candida albicans and aspergillus spp. we therefore studied the in vitro antifungal activity of cay-1 against non-germinating conidia and hyphae of clinical isolates of the dermatophytes trichophyton mentagrophytes, t. rubrum ... | 2008 | 18608885 |
| antimicrobial activities of gloriosa superba linn (colchicaceae) extracts. | the methanol extract of the rhizomes of gloriosa superba linn (colchicaceae) and its subsequent fractions in different solvent systems were screened for antibacterial and antifungal activities. excellent antifungal sensitivity was expressed by the n-butanol fraction against candida albicans and candida glaberata (up to 90%) and against trichophyton longifusus (78%) followed by the chloroform fraction against microsporum canis (80%). in the antibacterial bioassay, the crude extract and subsequent ... | 2008 | 18615278 |
| dysgonic strain of microsporum canis pseudomycetoma in a domestic long-hair cat. | a 4-year-old domestic long-hair cat was presented with two large non-painful, ulcerated and suppurative lesions over the flanks. histopathology and cytology were consistent with fungal pyogranulomatous inflammation. culture of tissue yielded a dysgonic strain of microsporum canis. the cat was treated successfully by staged en bloc resections of the lesions, followed by oral ketoconazole, then oral terbinafine. this is the first reported case of dermatophytic pseudomycetoma in a domestic long-hai ... | 2008 | 18673475 |
| childhood dermatomycoses study in sfax hospital, tunisia. | mycoses are frequent affections in childhood. fungal type varies according to the age and the affected organ. the aim of this study was to determine the aetiological agents of childhood dermatomycoses and to draw attention to the diversity of their clinical manifestations. retrospective study dealing with children's cases with age <16-year old and having dermatomycosis diagnosed between 1991 and 2005 at the parasitology and mycology laboratory of sfax university hospital. a total of 4559 childre ... | 2008 | 18498308 |
| susceptibility of dermatophyte isolates obtained from a large worldwide terbinafine tinea capitis clinical trial. | our group, in collaboration with seven other laboratories, has recently developed a method to determine the susceptibility of dermatophytes. | 2008 | 18510668 |
| antimicrobial activity of brazilian copaiba oils obtained from different species of the copaifera genus. | the antimicrobial activity of copaiba oils was tested against gram-positive and gram-negative bacteria, yeast, and dermatophytes. oils obtained from copaifera martii, copaifera officinalis, and copaifera reticulata (collected in the state of acre) were active against gram-positive species (staphylococcus aureus, methicillin-resistant s. aureus, staphylococcus epidermidis, bacillus subtilis, and enterococcus faecalis) with minimum inhibitory concentrations ranging from 31.3-62.5 microg/ml. the oi ... | 2008 | 18545856 |
| in vitro activity of penicillium chrysogenum antifungal protein (paf) and its combination with fluconazole against different dermatophytes. | strains of five dermatophyte species (microsporum canis, microsporum gypseum, trichophyton mentagrophytes, trichophyton rubrum and trichophyton tonsurans) were selected for testing against penicillium chrysogenum antifungal protein (paf) and its combination with fluconazole (fcz). inhibition of microconidia germination and growth was detected with mics of paf ranging from 1.56 to 200 microg ml(-1) when it was used alone, or at constant concentration (100 microg ml(-1)) in combination with fcz at ... | 2008 | 18574706 |
| single-step pcr using (gaca)4 primer: utility for rapid identification of dermatophyte species and strains. | dermatophytes are fungi that belong to three genera: epidermophyton, microsporum, and trichophyton. identification of dermatophyte species is essential for appropriate diagnosis and treatment of dermatophytosis. routine identification depends on macroscopic and microscopic morphology, which is time-consuming and does not identify dermatophyte strains. in this study, two pcr-based methods were compared for their abilities to identify 21 dermatophyte isolates obtained from egyptian patients to the ... | 2008 | 18579714 |
| reconstructed interfollicular feline epidermis as a model for the screening of antifungal drugs against microsporum canis. | a fully differentiated reconstructed interfollicular feline epidermis (rfe) was recently developed in vitro. it was shown to be relevant for the study of microsporum canis-epidermal interactions. in this study, rfe was evaluated as a potential model for the in vitro screening of drugs against m. canis. as a preliminary step, the minimum inhibitory concentration of miconazole nitrate against m. canis ihem 21239 grown on sabouraud's dextrose agar was determined to be 0.3 microg ml(-1). rfe grown a ... | 2008 | 18477328 |
| immunoprophylaxis of dermatophytosis in animals. | dermatophytosis is a relatively common disease in many countries occurring endemically both in companion and food animals. fungi belonging to the genera trichophyton and microsporum are most often isolated from clinical cases. measures to control and prevent dermatophytosis include sanitation, hygienic measures and treatment. in some countries, successful control and eradication have been achieved by mass vaccination of cattle and fur-bearing animals. vaccines containing live attenuated cells of ... | 2008 | 18478355 |
| dermatophytoses in animals. | dermatophytoses are one of the most frequent skin diseases of pets and livestock. contagiousness among animal communities, high cost of treatment, difficulty of control measures, and the public health consequences of animal ringworm explain their great importance. a wide variety of dermatophytes have been isolated from animals, but a few zoophilic species are responsible for the majority of the cases, viz. microsporum canis, trichophyton mentagrophytes, trichophyton equinum and trichophyton verr ... | 2008 | 18478363 |
| updates on the epidemiology of dermatophyte infections. | the spectrum of dermatophytes isolated from skin lesions had changed in last 70 years. before the second world war in germany, microsporum audouinii and epidermophyton floccosum ranked the first, whereas trichophyton rubrum is the most common dermatophyte since the fifties of last century, accounting for 80-90% of the strains, followed by t. mentagrophytes. this evolution is typical for central and north europe and it needs to be connected with the increase in the incidence of tinea pedis. in co ... | 2008 | 18478365 |
| comparison of the activities of four antifungal agents in an in vitro model of dermatophyte nail infection. | onychomycosis is a difficult condition to treat and cure rates are disappointing. moreover fungicidal action of antifungal agents in nccls assays and their rapid accumulation in nails in vivo are not compatible with the duration of treatment. | 2008 | 19882010 |
| comma hairs: a dermatoscopic marker for tinea capitis: a rapid diagnostic method. | dermatoscopy and videodermatoscopy have been used for several years in the diagnosis of skin disorders. | 2008 | 19119131 |
| dermatophyte infections in patients attending a tertiary care hospital in northern italy. | we studied dermatophyte infections in patients attending the dermatology outpatients clinic of s. matteo hospital pavia, italy, during the period 2004-2006. a total of 100 samples were collected from 95 patients; 97 dermatophytes and 3 keratinophylic fungi were isolated. trichophyton rubrum was the most frequent dermatophyte isolated (42.3%), followed by microsporum canis (31%), t. mentagrophytes (14.5%) and m. gypseum (9.2%). less frequently isolated were epidermophyton floccosum and t. violace ... | 2008 | 19123311 |
| ethnoveterinary study for antidermatophytic activity of piper betle, alpinia galanga and allium ascalonicum extracts in vitro. | crude ethanolic extracts of piper betle leaves (piperaceae), alpinia galanga rhizomes (zingiberaceae) and allium ascalonicum bulbs (liliaceae) were tested against selected zoonotic dermatophytes (microsporum canis, microsporum gypseum and trichophyton mentagrophyte) and the yeast-like candida albicans. a broth dilution method was employed to determine the inhibitory effect of the extracts and compared to those of ketoconazole and griseofulvin. all extracts suppressed the growth of the fungi in a ... | 2008 | 17482221 |
| identification of dermatophyte species causing onychomycosis and tinea pedis by maldi-tof mass spectrometry. | identification of dermatophytes is currently performed based on morphological criteria and is increasingly supported by genomic sequence comparison. the present study evaluates an alternative based on the analysis of clinical fungal isolates by mass spectrometry. samples originating from skin and nail were characterized morphologically and by sequencing the internal transcribed spacer 1 (its1), its2 and the 5.8s rdna regions of the rdna clusters. in a blind comparative study, samples were analyz ... | 2008 | 17979969 |
| fungal skin infections among prison inmates in abakaliki, nigeria. | of 402 prison inmates screened for fungal skin lesions, 79 (19.7%) showed skin lesions, which proved mycologically positive by microscopy and culture. dermatophytes were responsible for skin lesions in 61 (77.2%) of the inmates, while non-dermatophytes accounted for 18 (22.8%) of the lesions. the dermatophytes recovered were mostly anthropophilic and included trichophyton rubrum 33 (41.8%); t. mentagrophytes var. interdigitale 3 (3.8%); t. tonsurans 3 (3.8%); t. violaceum 2 (2.5%); epidermophyto ... | 2008 | 18076595 |
| atypical microsporum canis variant in an immunosuppressed child. | a 10-year old boy with x-chromosomal adrenoleukodystrophy presented with scaly patches on the scalp and diffuse effluvium. he was on immunosuppressive therapy because of a chronic graft-versus-host-reaction after allogenic bone marrow transplantation. at home he had been in contact with cats, rabbits and guinea pigs. through wood light and koh examination, we confirmed the diagnosis of tinea capitis and started antimycotic therapy. the morphology of the culture first suggested epidermophyton flo ... | 2008 | 18081856 |
| dna microarray based on arrayed-primer extension technique for identification of pathogenic fungi responsible for invasive and superficial mycoses. | an oligonucleotide microarray based on the arrayed-primer extension (apex) technique has been developed to simultaneously identify pathogenic fungi frequently isolated from invasive and superficial infections. species-specific oligonucleotide probes complementary to the internal transcribed spacer 1 and 2 (its1 and its2) region were designed for 24 species belonging to 10 genera, including candida species (candida albicans, candida dubliniensis, candida famata, candida glabrata, candida tropical ... | 2008 | 18160452 |
| microsporum canis in a neonatal intensive care unit patient. | a 45-day-old male neonate (born 25 weeks and 5 days) presented with an annular, erythematosquamous eruption covering the head, neck, trunk, upper limbs and thighs. the eruption most resembled tinea corporis, however unusual the setting. routine fungal culture grew microsporum canis. no contacts could be identified. no previous case of tinea corporis had been seen in this neonatal unit, and very few reports are in the literature, particularly regarding this zoophilic organism. our patient cleared ... | 2008 | 18186843 |
| rapid identification and differentiation of trichophyton species, based on sequence polymorphisms of the ribosomal internal transcribed spacer regions, by rolling-circle amplification. | dna sequencing analyses have demonstrated relatively limited polymorphisms within the fungal internal transcribed spacer (its) regions among trichophyton spp. we sequenced the its region (its1, 5.8s, and its2) for 42 dermatophytes belonging to seven species (trichophyton rubrum, t. mentagrophytes, t. soudanense, t. tonsurans, epidermophyton floccosum, microsporum canis, and m. gypseum) and developed a novel padlock probe and rolling-circle amplification (rca)-based method for identification of s ... | 2008 | 18234865 |
| dermatophytoses in outpatients attending the dermatology center of avicenna hospital in qazvin, iran. | dermatophytosis is still being considered as one of the major public health problems in many parts of the world. to identify the prevalence and etiological agents of dermatophytoses, a study was carried out between 2004 and 2006. out of 1023 subjects suspected to have cutaneous mycoses, 348 (34%) patients were affected with dermatophytoses. the causative agents were identified macroscopically and microscopically after the clinical samples were subjected to potassium hydroxide examination and cul ... | 2008 | 18254753 |
| an epidemiological survey of tinea capitis in sarajevo, bosnia and herzegovina over a 10-year period. | the aim of this study was to determine the incidence and aetiological agents of tinea capitis in sarajevo area, bosnia and herzegovina, during a 10-year period (1997-2006). a total of 707 patients with suspected dermatophyte infections of scalp was analysed. tinea capitis was determined in 241 (34.1%) of these patients, in whom causative agents were identified in 209 (29.6%). zoophilic dermatophytes (91.8%) prevailed over anthropophilic (7.2%) and geophilic (1.0%) dermatophytes. microsporum cani ... | 2008 | 18254754 |
| characteristics of superficial fungal infections in the riyadh region of saudi arabia. | the prevalence and characteristics of superficial fungal infections (sfis) vary with climatic conditions, lifestyle, and population migration patterns. this study was undertaken to determine the characteristics of sfis amongst patients visiting the dermatology clinic of riyadh military hospital, riyadh, saudi arabia, during the period 2003-2005. | 2008 | 18289321 |
| antifungal activity of essential oils of croton species from the brazilian caatinga biome. | to find new antifungal agents among essential oils from brazilian croton species. | 2008 | 18298533 |
| frequency of yeasts and dermatophytes from healthy and diseased dogs. | the aim of this study was to investigate the presence of dermatophytes and yeasts in healthy and diseased dogs. a total of 633 samples were collected from 26 healthy animals (104 samples), 131 with dermatitis (343 samples), 74 with otitis (148 samples), and 19 with ocular diseases (38 samples). cultures from healthy animals were positive for malassezia pachydermatis in 13.5% (7/52) of samples from skin, 42.3% (11/26) from ear, and 3.8% (1/26) from eye. fungal growth was observed in 20.4% (70/343 ... | 2008 | 18319432 |
| [tinea capitis]. | tinea capitis is a widespread scalp infection in children caused by dermatophytes. in fact, it is the most common cutaneous mycosis in children but is uncommon in adults. the disease has been major public health concern for decades. some factors implicated in infection include poor personal hygiene, crowded living conditions, and low socioeconomic status. it can be caused by any pathogenic dermatophyte except for epidermophyton floccosum and trichophyton concentricum. trichophyton rubrum, the mo ... | 2008 | 18346430 |
| terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: results of two randomized, investigator-blinded, multicenter, international, controlled trials. | although griseofulvin is currently considered the primary antifungal agent used to treat tinea capitis in many countries, increasingly higher doses and longer durations of treatment are becoming necessary to achieve effective treatment. alternative antifungal therapies with shorter/simpler treatment regimens may be important to develop for this indication. | 2008 | 18378354 |
| in vitro antifungal activity of extracts and neolignans from piper regnellii against dermatophytes. | the present study was designated to evaluate the in vitro antidermatophyte activity of extracts from leaves of piper regnellii as well as of the bioactivity-directed isolation of neolignans. the antifungal assay was performed by microdilution techniques. the hydroalcoholic extract of piper regnellii leaves presented a strong activity against the dermatophyte fungi trichophyton mentagrophytes, trichophyton rubrum, microsporum canis and microsporum gypseum with mics of 15.62, 15.62, 15.62 and 62.5 ... | 2008 | 18394835 |
| ultraviolet c inactivation of dermatophytes: implications for treatment of onychomycosis. | onychomycosis responds to systemic antifungals and sometimes to topical lacquers, but alternative treatments are desirable. topical application of germicidal ultraviolet (uv) c radiation may be an acceptable and effective therapy for infected nails. | 2008 | 18410410 |
| experimental guinea pig model of dermatophytosis: a simple and useful tool for the evaluation of new diagnostics and antifungals. | the aim of this study was to establish a simple guinea pig model for the purpose of evaluating diagnostic principles and treatment modalities for dermatophytic infections. the following variables were evaluated; pre-treatment of the skin by shaving versus tape stripping, microsporum canis or trichophyton mentagrophytes test strains as etiologic agents, differences in inoculum concentrations, and inoculation with and without occlusion. the course of infection was evaluated clinically by redness a ... | 2008 | 18415837 |
| screening of chemical composition, antimicrobial and antioxidant activities of artemisia essential oils. | the chemical composition of essential oils isolated from aerial parts of seven wild sages from western canada -artemisia absinthium l., artemisia biennis willd., artemisia cana pursh, artemisia dracunculus l., artemisia frigida willd., artemisia longifolia nutt. and artemisia ludoviciana nutt., was investigated by gc-ms. a total of 110 components were identified accounting for 71.0-98.8% of the oil composition. high contents of 1,8-cineole (21.5-27.6%) and camphor (15.9-37.3%) were found in arte ... | 2008 | 18417176 |
| use of a sustained release preparation of clotrimazole to treat dermatophytosis in a siamang (hylobates syndactylus). | in november 2004, an adult male siamang (hylobates syndactylus) from the tisch family zoological gardens-jerusalem biblical zoo (israel) presented with skin lesions on various body parts. lesions consisted of alopecia and dry, crusty areas of hyperkeratosis. a diagnosis of dermatophytosis due to microsporum canis was determined by fungal culture of skin scraping taken from the edge of several lesions. treatment with various oral and topical antifungal agents such as griseofluvin, itraconozole, a ... | 2008 | 18432106 |
| identification of dermatophytes by sequence analysis of the rrna gene internal transcribed spacer regions. | identification of dermatophytes using the traditional method is sometimes problematic because of atypical microscopic or macroscopic morphology. the aim of this study was to evaluate the feasibility of using sequencing of the ribosomal internal transcribed spacer (its)1 and its2 regions for identification of 17 dermatophyte species. the its regions of 188 strains (62 reference strains and 126 clinical isolates) were amplified by pcr and sequenced. species identification was made by sequence comp ... | 2008 | 18436592 |
| [investigation of the agents and risk factors of dermatophytosis: a hospital-based study]. | the aims of this study were the detection of distribution of dermatophyte species isolated from the clinical samples of patients with dermatophytosis and the evaluation of risk factors for the development of dermatophytosis. a total of 441 skin, nail and scalp/hair specimens obtained from 301 patients (151 were male; age range 2 months-80 years, median 42 years) and 884 foot and hand skin and nail specimens obtained from 221 control subjects (110 were male; age range 5-75 years, median 36 years) ... | 2008 | 18444566 |
| dermatophytosis caused by microsporum canis and microsporum gypseum in free-living bradypus variegatus (schiz, 1825) in the state of pernambuco, brazil. | three cases of dermatophytosis in free living brown-throated three-toed sloths (bradypus variegatus) in the zona da mata, north of pernambuco state, brazil, were studied. two animals presented areas of alopecia on the pelvic member and thorax and one animal on the pelvic member only. the three animals presented scabs. hair and scabs samples were submitted to microscopical examination after treatment with a 30 % koh and cultivated in mycosel agar. the direct examination indicated the presence of ... | 2008 | 24031255 |
| antibacterial and antifungal activities of andrachne cordifolia muell. | the crude methanolic extract of andrachne cordifolia muell. (euphorbiaceae) and its various fractions in different solvent systems (chloroform, ethyl acetate and n-butanol) were screened for antibacterial and antifungal activities. crude extract and subsequent fractions demonstrated moderate to excellent antibacterial activities against the tested pathogens. highest antibacterial activity was displayed by both chloroform and ethyl acetate fractions (100%) followed by the crude extract (68%) agai ... | 2007 | 18237026 |
| cytobrush-culture method to diagnose tinea capitis. | this is a comparative study to isolate the dermatophytes of tinea capitis using the cytobrush and comparing it versus the standard method. a prospective, observational, comparative trial of 178 probable cases of tinea capitis was conducted in two dermatological centers. each patient underwent mycological tests that included direct exam with koh and cultures with either of two methods: scraping the scalp to remove hair and cell debris, and the cytobrush. a total of 135 clinically and mycologicall ... | 2007 | 17520340 |
| microsporum canis: report of a primary school outbreak. | microsporum canis is the causative organism in less than 10% of all tinea capitis infections in the uk. transmission is generally via contact with an infected family pet and there are only rare reports of case clustering. this article describes an outbreak of m. canis in a primary school classroom demonstrating human-to-human spread from an index case who was presumed to have acquired the infection prior to arriving in the uk. there was no suggestion of clinical improvement following 4 weeks of ... | 2007 | 17535194 |
| pseudomycetoma for microsporum canis: report of a case diagnosed by fine needle aspiration biopsy. | fine needle aspiration biopsy (fnab) of the skin is useful in subcutaneous lesions. dermatophytes are almost exclusively superficial cutaneous mycoses and constitute 70-80% of all mycoses and 5% of dermatologic consultations. inflammatory and invasive forms, as well as infections that remain in chronic forms or persist in spite of treatment, are more frequent in immunocompromised individuals. the clinicalpresentations of these invasive cases are dermatopbytic granulomas (granuloma of wilson-majo ... | 2007 | 17536547 |
| antifungal activity of the silver ion against contaminated fabric. | an anti-fungal efficacy test of the silver laundry machine, which electrically generates silver ions, was carried out against four fungi--trichophyton rubrum, candida albicans, microsporum canis and aspergillus flavus--which cause major fungal infection in humans and animals. compared with the conventional laundry machine, washing with the silver laundry machine regardless of detergent use was effective against most of the fungi with about 4 log(10) (cfu ml(-1)) reduction and eliminated almost a ... | 2007 | 17576317 |
| prevalence of tinea capitis in southern kuwait. | tinea capitis of the scalp, an infection caused by dermatophytes, produces a significant health problem especially among school children. the object of this study was to highlight the prevalence of tinea capitis in southern kuwait. during this retrospective study from 1998 to 2003, 1737 suspected cases were examined, 986 (58.6%) were men and 751 (43.2%) were women of which 371 cases were diagnosed as tinea capitis. of 371 cases of tinea capitis, males comprised 54.2% and females 45.8%. young chi ... | 2007 | 17576327 |
| in vivo efficacy and pharmacokinetics of voriconazole in an animal model of dermatophytosis. | the standard treatment for tinea capitis caused by microsporum species for many years has been oral griseofulvin, which is no longer universally marketed. voriconazole has been demonstrated to inhibit growth of microsporum canis in vitro. we evaluated the efficacy and tissue pharmacokinetics of oral voriconazole in a guinea pig model of dermatophytosis. guinea pigs (n = 16) were inoculated with m. canis conidia on razed skin. voriconazole was dosed orally at 20 mg/kg/day for 12 days (days 3 to 1 ... | 2007 | 17576826 |
| reconstructed interfollicular feline epidermis as a model for microsporum canis dermatophytosis. | microsporum canis is a pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis. the complexity of mechanisms involved in dermatophytic infections makes relevant in vivo studies particularly difficult to perform. the aim of this study was to develop a new in vitro model of m. canis dermatophytosis using feline fetal keratinocytes in reconstructed interfollicular epidermis, and to investigate its relevance in studying the host-pathogen relationship. histological anal ... | 2007 | 17577064 |
| extracellular proteolytic activity and molecular analysis of microsporum canis strains isolated from symptomatic and asymptomatic cats. | microsporum canis is the main zoophylic dermatophyte in dogs and cats, and it is also an important zoonotic agent. the literature showed that cats are asymptomatic carriers of m. canis. this is apparently due to host resistance and/or the presence of strains with lower virulence. this study was aimed to evaluate the keratinolytic, elastinolytic and collagenolytic activities of m. canis strains and their relationship with symptomatic and asymptomatic cats. in addition, these strains were analysed ... | 2007 | 17592886 |
| in vitro antifungal activity of rhazya stricta. | rhazya stricta is a small glabrous shrub, widely distributed throughout western asia from yemen to arabia, to the north west province of india and abundantly found in various regions of pakistan. larvicidal and antifungal studies of polar and non polar aerial parts extracts of rhazya stricta were performed using brine shrimps larvae for larvicidal study and for antifungal study microorganisms, trichophyton longifusis, aspergillus flavus, candida albicans, microsporum canis and fusarium solani we ... | 2007 | 17604249 |
| design, synthesis, and antifungal activities of novel 1h-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (cyp51). | a series of fluconazole (1) analogues, compounds 3a-k, were prepared as potential antifungal agents. they were designed by computational docking experiments to the active site of the cytochrome p450 14alpha-sterol demethylase (cyp51), whose crystal structure is known. preliminary biological tests showed that most of the target compounds exhibit significant activities against the eight most-common pathogenic fungi. thereby, the most potent congener, 1-[(4-tert-butylbenzyl)(cyclopropyl)amino]-2-(2 ... | 2007 | 17638327 |
| familial keratosis follicularis spinulosa decalvans associated with woolly hair. | keratosis follicularis spinulosa decalvans (kfsd) is a rare inherited disorder of keratinization clinically characterized by diffuse follicular hyperkeratosis, progressive scarring alopecia of scalp, eyebrows and eyelashes, corneal dystrophy and photophobia. woolly hair is a hereditary condition, transmitted as an autosomal dominant or recessive trait, usually seen in caucasians at birth or shortly after, in which there are curly, thick, often heavily pigmented hairs. we report two cases, a son ... | 2007 | 17651168 |
| diagnosis of common dermatophyte infections by a novel multiplex real-time polymerase chain reaction detection/identification scheme. | in the absence of a functional dermatophyte-specific polymerase chain reaction (pcr), current diagnosis of dermatophytoses, which constitute the commonest communicable diseases worldwide, relies on microscopy and culture. this combination of techniques is time-consuming and notoriously low in sensitivity. | 2007 | 17672875 |
| attempted treatment of tigers (panthera tigris) infected with microsporum canis. | an outbreak of dermatophytosis caused by microsporum canis occurred in tigers (panthera tigris) at an exotic felid sanctuary in 2003. in an attempt to find an effective, practical, safe, and affordable method for controlling this epizootic, a clinical treatment trial was conducted. nonalopecic tigers were studied to address the inapparent carrier state observed at the facility. the efficacy of three topical and environmental treatment combinations of a 2% lime sulfur solution and a peroxide-base ... | 2007 | 17679509 |
| rna silencing in the dermatophyte microsporum canis. | dermatomycoses caused by microsporum canis are frequent in domestic animals and easily transmissible to humans. several proteases secreted by this fungus were identified as potential virulence factors, but the construction of deficient strains is required to investigate their role in the pathogenesis of the disease. using target genes encoding two of these proteases, a first evaluation of the utility of rna-mediated silencing as a reverse genetic tool in dermatophytes was carried out. sub3 and d ... | 2007 | 17681006 |
| epidemiology of tinea capitis in europe: current state and changing patterns. | tinea capitis (scalp ringworm) is the most common dermatophyte infection of the scalp affecting mainly children and rarely adults. the epidemiology of tinea capitis varies within different geographical areas throughout the world. it may occur sporadically or epidemically and an increase in its incidence has been noted over the last few decades. the aim of the study is to obtain a general overview of the current state and changing pattern of tinea capitis in europe. according to the literature, t ... | 2007 | 17681048 |
| identification of dermatophytes by an oligonucleotide array. | species of dermatophytes are classified into three anamorphic (asexual) genera, epidermophyton, microsporum, and trichophyton. conventional methods used to identify dermatophytes are often lengthy and may be inconclusive because of atypical microscopic or colony morphology. based on the internal transcribed spacer 1 (its-1) and its-2 sequences of the rrna genes, an oligonucleotide array was developed to identify 17 dermatophyte species. the method consisted of pcr amplification of the its region ... | 2007 | 17687010 |
| tinea incognito due to microsporum canis in a 76-year-old woman. | 2007 | 17721764 | |
| use of lime sulphur and itraconazole to treat shelter cats naturally infected with microsporum canis in an annex facility: an open field trial. | dermatophytosis is the most common contagious and infectious skin disease of cats. it is of particular importance in animal shelters because it is a known zoonosis, highly contagious, and easily transmitted. in this open clinical trial, 58 cats with confirmed microsporum canis dermatophytosis and 32 uninfected bonded pairs or littermates were treated with a combination of 21 days of oral itraconazole (10 mg kg(-1)) and twice weekly lime sulphur rinses until cured. cats were not clipped in this t ... | 2007 | 17845620 |
| evaluation of microdilution and disk diffusion methods for antifungal susceptibility testing of dermatophytes. | a total of 63 dermatophyte strains belonging to 6 species (trichophyton rubrum (16), t. mentagrophytes (16), t. tonsurans (20), t. violaceum (2), microsporum canis (7), and epidermophyton floccosum (2)) were tested for their in vitro susceptibility to a range of antifungal drugs using disk diffusion and clinical laboratory standards institute m38-a (clsi, formerly nccls) broth microdilution methods. the antifungals used were ciclopirox (cic), terbinafine (ter), griseofulvin (gre), fluconazole (f ... | 2007 | 17885958 |
| a virulent genotype of microsporum canis is responsible for the majority of human infections. | the zoophilic dermatophyte species microsporum canis belongs to the arthroderma otae complex and is known to mate with tester strains of that teleomorph species, at least in the laboratory. human infections are likely to be acquired from the fur of cats, dogs and horses. epidemiological studies to reveal sources and routes of infection have been hampered by a lack of polymorphic molecular markers. human cases mainly concern moderately inflammatory tinea corporis and tinea capitis, but, as cases ... | 2007 | 17893177 |
| antimicrobial activity and the major components of the essential oil of plectranthus cylindraceus. | the traditional uses of the aerial parts of fresh plectranthus cylindraceus by the dhofaris in oman were investigated on the basis of antimicrobial properties and composition of its herb oil. | 2007 | 17897226 |
| antimicrobial activity of wax and hexane extracts from citrus spp. peels. | antibacterial and antifungal properties of wax and hexane extracts of citrus spp. peels were tested using bioautographic and microdilution techniques against three plant pathogenic fungi (penicillium digitatum, curvularia sp., and colletotrichum sp.), two human pathogens (trichophyton mentagrophytes and microsporum canis), and two opportunistic bacteria (escherichia coli and staphylococcus aureus). two polymethoxylated flavonoids and a coumarin derivative, were isolated and identified from peel ... | 2007 | 17923995 |
| [tinea capitis - a recurring problem]. | in the first quarter of the 20th century, tinea capitis represented the most important dermatomycological diagnosis in europe. for its significant social impacts (affecting children, potential permanent disfiguration), developed countries introduced strict anti-epidemic measures which, together with the discovery of griseofulvin in 1960, contributed to nearly complete eradication of the disease in central europe. since 1980s, however, the incidence of tinea capitis has increased to become a seri ... | 2007 | 17929221 |
| a 7-year survey of dermatophytoses in crete, greece. | dermatophytoses are of worldwide distribution. epidemiological studies concerning dermatophyte infections have been performed in many countries and differences in the incidence and the aetiological agents have been reported in different geographical locations. this study was undertaken to investigate the prevailing species of dermatophytes in the island of crete, greece, and their pattern of infection during a 7-year period (1997-2003). a total of 5544 samples obtained from 3751 patients with cl ... | 2007 | 17944710 |
| dermatophytoses in cats and humans in central italy: epidemiological aspects. | two hundred hair/skin samples were collected from 2002 to 2004 from two groups of cats (privately owned and stray cats from a shelter) and 165 samples were obtained during the same period from persons in whom dermatophyte infection was highly suspected. the epidemiological data were statistically evaluated. thirteen of the 100 privately owned cats (13%) and 100% of the stray cats were positive; of the 165 human samples examined 109 (66%) were positive for dermatophytes. microsporum canis was the ... | 2007 | 17944712 |
| antifungal activities of the essential oils in syzygium aromaticum (l.) merr. et perry and leptospermum petersonii bailey and their constituents against various dermatophytes. | this study was carried out in order to investigate the potential of using plant oils derived from leptospermum petersonii bailey and syzygium aromaticum l. merr. et perry as natural antifungal agents. the antifungal effects of essential oils at concentrations of 0.05, 0.1, 0.15, and 0.2 mg/ml on the dermatophytes microsporum canis (kctc 6591), trichophyton mentagrophytes (kctc 6077), trichophyton rubrum (kccm 60443), epidermophyton floccosum (kccm 11667), and microsporum gypseum were evaluated u ... | 2007 | 17978807 |
| five-hour diagnosis of dermatophyte nail infections with specific detection of trichophyton rubrum. | a rapid two-step dna extraction method and a multiplex pcr for the detection of dermatophytes in general and trichophyton rubrum specifically were developed and evaluated with dna extracted from pure cultures and from clinically diseased nails. dna from the following dermatophytes was used: epidermophyton floccosum, microsporum audouinii, microsporum canis, microsporum gypseum, microsporum nanum, trichophyton mentagrophytes, trichophyton rubrum, trichophyton schoenleinii, trichophyton soudanense ... | 2007 | 17267633 |
| epidemiology of dermatophytic infections in rome, italy: a retrospective study from 2002 to 2004. | in the present study, we determined the incidence of dermatophyte species causing superficial mycoses among outpatients referred to the department of dermatology of the "la sapienza" university of rome between 2002 and 2004. of the 3160 subjects studied, 1275 (40.3%) were positive for fungal infection, but only 252 (19.7%) of these had infections caused by dermatophytes. the dermatophyte most frequently isolated was microsporum canis. our epidemiological data were compared with those obtained pr ... | 2007 | 17325945 |
| analysis of the dermatophyte species isolated in the british isles between 1980 and 2005 and review of worldwide dermatophyte trends over the last three decades. | infections of the skin, hair and nails by dermatophyte fungi are common in developed and developing countries alike. however, the species involved and the resulting clinical entities vary both geographically and with time. we have surveyed 15,333 dermatophytes obtained from primary isolations at the mycology reference laboratory, bristol, uk from 1980 through 2005. several striking trends in dermatophyte prevalence were apparent over this period. the relative frequencies of isolations of microsp ... | 2007 | 17365649 |
| chemical composition, toxicological aspects and antifungal activity of essential oil from lippia sidoides cham. | the aims of this study were to test the essential oil from lippia sidoides cham. for antifungal activity, in vitro, against candida spp. and microsporum canis, to evaluate its acute and subchronic toxicological effects, in vivo, and to determine its chemical constituents. | 2007 | 17376793 |
| pseudomycetoma caused by microsporum canis in an immunosuppressed patient: a case report and review of the literature. | a 65-year-old woman with a history of liver and kidney transplantation presented with a pruritic and tender rash of 2-year duration on her left knee. | 2007 | 17448202 |
| identification of microsporum canis from dermatophytic pseudomycetoma in paraffin-embedded veterinary specimens using a common pcr protocol. | the effectiveness of a simple pcr protocol performed on paraffin-embedded tissues, obtained from histopathologically and culturally diagnosed cases of dermatophytic pseudomycetoma dpm was tested. the specimens were investigated using previously described primers (dh1l and dh1r) targeting the 18s rdna gene and amplifying a 183-bp fragment. microsporum canis was identified from all samples. the pcr protocol described in the present work demonstrated a 100% concordant result comparing the molecular ... | 2007 | 17472620 |
| glucose improves the in vitro viability of microsporum canis and trichophyton mentagrophytes var. mentagrophytes. | we describe simple and cost-effective methods using carbohydrates to improve the in vitro viability of dermatophytes. glucose and sucrose in different concentrations (3, 6, 9 and 12%) were used to maintain fifteen strains of m. canis and t. mentagrophytes var. mentagrophytes at 4 and -20 degrees c. the strains were phenotypically analyzed before storage and reevaluated at 1, 3, 6 and 9 months. at 1 and 3 months, any alterations in the viability or phenotype pattern of the stored strains were not ... | 2007 | 17254654 |
| species distribution and antifungal susceptibilities of dermatophytes during a one year period at a university hospital in turkey. | dermatophyte infections have been considered to be a major public health problem in many parts of the world. the aim of this study was to determine the causative agents of dermatophytoses and their antifungal susceptibilities in a turkish university hospital, west of turkey. a total of 926 patients suspected to have dermatophytic lesions were examined over a period of 1 year (2001-2002). samples collected from skin, hair and nails were submitted to direct microscopical examination using koh and ... | 2007 | 17305776 |
| asymptomatic dermatophyte scalp carriage in school children in adana, turkey. | the aim of this study was to determine the prevalence of asymptomatic dermatophyte scalp carriage and symptomatic tinea capitis in adana province, cukurova region, turkey. for this purpose, a screening study was performed in five schools, between january 2004 and may 2005, covering a total of 5143 children with 2740 (53.3%) boys and 2403 (46.7%) girls, aged 7-14 years (9.6 +/- 2.0). the diagnosis was made using the cotton swab method with inoculation onto sabouraud glucose agar amended with cycl ... | 2007 | 17305777 |
| atypical favic invasion of the scalp by microsporum canis: report of a case and review of reported cases caused by microsporum species. | favus is an uncommon pattern of dermatophytic infection of the scalp, glabrous skin and nails. we report the first documented case of favus of the scalp caused by microsporum canis in an immunocompetent 8-year-old girl. the classic and various atypical clinical presentations of favus are discussed, as well as a brief review of the literature given. | 2007 | 17305783 |
| anti-fungal activity of crude extracts and essential oil of moringa oleifera lam. | investigations were carried out to evaluate the therapeutic properties of the seeds and leaves of moringa oleifera lam as herbal medicines. ethanol extracts showed anti-fungal activities in vitro against dermatophytes such as trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, and microsporum canis. gc-ms analysis of the chemical composition of the essential oil from leaves showed a total of 44 compounds. isolated extracts could be of use for the future development of ant ... | 2007 | 16406607 |
| in vitro activity of citrus bergamia (bergamot) oil against clinical isolates of dermatophytes. | recently, bergamot oil was shown to be a potent antifungal agent in vitro against clinically important candida species. in this study, the activities of bergamot natural essence and its furocoumarin-free and distilled extracts on dermatophytes such as trichophyton, microsporum and epidermophyton species were investigated. | 2007 | 17118937 |
| use of isolated infected spores to determine the sporocidal efficacy of two commercial antifungal rinses against microsporum canis. | in this study, isolated infective microsporum canis spores were used in an in vitro test model to compare the sporocidal activity of two commercial topical antifungal rinses. the two commercial test solutions used in the study were a lime sulphur solution 97.8% (lymdyp) and miconazole base 5.2%/chlorhexidine gluconate 5.9% mixture (malaseb concentrate rinse). water and household bleach were used as controls. isolated infective spores were harvested from infected hairs and 500 microl of the spore ... | 2007 | 17222242 |
| in vitro antifungal activity of 2-(4-substituted phenyl)-3(2h)-isothiazolones. | the in vitro antifungal activity of several n2-phenyl-3(2h)-isothiazolones substituted at c4 of the phenyl moiety with heterocyclic nucleus or groups of different physico-chemical properties against four human pathogenic fungi was determined by broth macrodilution method; results were compared with those obtained with itraconazole and ketoconazole. these isothiazolones showed moderate to high activity against some or all tested strains and in comparison with the reference drugs, 5-chloro-2-(4-ni ... | 2007 | 18450218 |
| steroidal glycosides from the underground parts of allium ursinum l. and their cytostatic and antimicrobial activity. | the aim of this study was the isolation and structural elucidation of steroidal glycosides from the underground parts of ramson allium ursinum l. the structures of the isolated compounds were established based upon chromatographic methods and 1d- and 2d-nmr, ms and ir analyses. the mixture of two steroidal saponins: (25r)-spirost-5-en-3b-ol tetrasaccharide and (25r)-spirost-5, 25(27)-dien-3b-ol tetrasaccharide, along with a 3-hydroxypregna-5,16-dien-20-one glycoside were identified. the results ... | 2006 | 20085228 |
| in-vitro antibacterial, antifungal and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes with furanylmethyl- and thienylmethyl-dithiolenes: [1, 3-dithiole- 2-one and 1,3-dithiole-2-thione]. | some antibacterial and antifungal furanylmethyl-and thienylmethyl dithiolenes and, their co(ii), cu(ii), ni (ii) and zn (ii) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against four gram-negative; escherichia coli, pseudomonas aeruginosa, salmonella typhi and shigella flexeneri, and two gram-positive; bacillus subtilis and staphylococcus aureus bacterial strains, and for in-vitro antifungal activity against trichophyton longifusus, candid ... | 2006 | 17252947 |