Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| mosquito electrocuting traps for directly measuring biting rates and host-preferences of anopheles arabiensis and anopheles funestus outdoors. | mosquito biting rates and host preferences are crucial determinants of human exposure to vector-borne diseases and the impact of vector control measures. the human landing catch (hlc) is a gold standard method for measuring human exposure to bites, but presents risks to participants by requiring some exposure to mosquito vectors. mosquito electrocuting traps (mets) represent an exposure-free alternative to hlcs for measuring human exposure to malaria vectors. however, original met prototypes wer ... | 2019 | 30885205 |
| exposure to the insecticide-treated bednet permanet 2.0 reduces the longevity of the wild african malaria vector anopheles funestus but gste2-resistant mosquitoes live longer. | despite the increased report of insecticide resistance in malaria vectors, its impact on mosquito's life-traits after exposure to insecticide-treated nets remains under investigated. here, we assessed the effects of exposure to permanet 2.0 on several life traits of an. gambiae s.l. and an. funestus s.l. field mosquitoes in cameroon. | 2019 | 30870507 |
| a previously unreported potential malaria vector in a dry ecology of kenya. | in kenya, malaria remains a major public health menace equally affecting the semi-arid to arid ecologies. however, entomologic knowledge of malaria vectors in such areas remains poor. | 2019 | 30744665 |
| population genetics of anopheles funestus, the african malaria vector, kenya. | anopheles funestus is among the major malaria vectors in kenya and sub-saharan africa and has been recently implicated in persistent malaria transmission. however, its ecology and genetic diversity remain poorly understood in kenya. | 2019 | 30621756 |
| protecting migratory farmers in rural tanzania using eave ribbons treated with the spatial mosquito repellent, transfluthrin. | many subsistence farmers in rural southeastern tanzania regularly relocate to distant farms in river valleys to tend to crops for several weeks or months each year. while there, they live in makeshift semi-open structures, usually far from organized health systems and where insecticide-treated nets (itns) do not provide adequate protection. this study evaluated the potential of a recently developed technology, eave ribbons treated with the spatial repellent transfluthrin, for protecting migrator ... | 2019 | 31823783 |
| mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by next generation sequencing of plasmodium falciparum. | plasmodium falciparum drug resistance surveillance is key to successful disease control and eradication. contemporary methods that only allow determination of prevalence of resistance are expensive, time consuming and require ethical considerations. a newer method involving next generation sequencing (ngs) permits obtaining frequency of resistance while allowing to detect minority variants in mixed infections. here, ngs was tested for p. falciparum resistance marker detection in mosquito samples ... | 2019 | 31623623 |
| cis-regulatory cyp6p9b p450 variants associated with loss of insecticide-treated bed net efficacy against anopheles funestus. | elucidating the genetic basis of metabolic resistance to insecticides in malaria vectors is crucial to prolonging the effectiveness of insecticide-based control tools including long lasting insecticidal nets (llins). here, we show that cis-regulatory variants of the cytochrome p450 gene, cyp6p9b, are associated with pyrethroid resistance in the african malaria vector anopheles funestus. a dna-based assay is designed to track this resistance that occurs near fixation in southern africa but not in ... | 2019 | 31604938 |
| bacterial larvicides used for malaria vector control in sub-saharan africa: review of their effectiveness and operational feasibility. | several trials and reviews have outlined the potential role of larviciding for malaria control in sub-saharan africa (ssa) to supplement the core indoor insecticide-based interventions. it has been argued that widespread use of long-lasting insecticide-treated nets (llins) and indoor residual spraying (irs) interventions in many parts of africa result in many new areas with low and focal malaria transmission that can be targeted with larvicides. as some countries in ssa are making good progress ... | 2019 | 31470885 |
| vectorial transmission of malaria in major districts of côte d'ivoire. | to better understand the influence of periodic mass distribution of long-lasting insecticidal nets (llins) on malaria transmission, a 1-yr entomological survey was conducted in three major districts of côte d'ivoire. mosquitoes were sampled by human landing catches (hlc) in urban and rural areas of san pedro and abidjan (coastal), and in yamoussoukro (central). mosquitoes were identified morphologically and by molecular methods. the plasmodium falciparum circumsporozoite (csp) indices were measu ... | 2019 | 31785095 |
| susceptibility testing of anopheles malaria vectors with the neonicotinoid insecticide clothianidin; results from 16 african countries, in preparation for indoor residual spraying with new insecticide formulations. | in 2017, more than 5 million house structures were sprayed through the u.s. president's malaria initiative, protecting more than 21 million people in sub-saharan africa. new irs formulations, sumishield™ 50wg and fludora fusion™ wp-sb, became world health organization (who) prequalified vector control products in 2017 and 2018, respectively. both formulations contain the neonicotinoid active ingredient, clothianidin. the target site of neonicotinoids represents a novel mode of action for vector ... | 2019 | 31370898 |
| anopheles parensis contributes to residual malaria transmission in south africa. | understanding the contribution of outdoor-resting anopheles mosquitoes to residual malaria transmission is important in terms of scaling up vector control towards malaria elimination in south africa. the aim of this project was to assess the potential role of anopheles parensis and other anopheles species in residual malaria transmission, using sentinel surveillance sites in the umkhanyakude district of northern kwazulu-natal province. | 2019 | 31358015 |
| diagnostic dose determination and efficacy of chlorfenapyr and clothianidin insecticides against anopheles malaria vector populations of western kenya. | malaria vector control is dependent on chemical insecticides applied to walls by indoor residual spraying or on long-lasting insecticidal nets. the emergence and spread of insecticide resistance in major malaria vectors may compromise malaria control and elimination efforts. the aim of this study was to estimate a diagnostic dose for chlorfenapyr (class: pyrrole) and clothianidin (class: neonicotinoid) and assess the baseline susceptibility of three major anopheles malaria vectors of western ken ... | 2019 | 31315614 |
| analysis-ready datasets for insecticide resistance phenotype and genotype frequency in african malaria vectors. | the impact of insecticide resistance in malaria vectors is poorly understood and quantified. here a series of geospatial datasets for insecticide resistance in malaria vectors are provided, so that trends in resistance in time and space can be quantified, and the impact of resistance found in wild populations on malaria transmission in africa can be assessed. specifically, data have been collated and geopositioned for the prevalence of insecticide resistance, as measured by standard bioassays, i ... | 2019 | 31308378 |
| suppression of malaria vector densities and human infection prevalence associated with scale-up of mosquito-proofed housing in dar es salaam, tanzania: re-analysis of an observational series of parasitological and entomological surveys. | in the city of dar es salaam, tanzania, rapid and spontaneous scale-up of window screening occurred through purely horizontal commercial distribution systems without any public subsidies or promotion. scale-up of window screening coincided with a planned evaluation of programmatic, vertically managed scale-up of regular larvicide application as an intervention against malaria vectors and transmission. we aimed to establish whether scale-up of window screening was associated with suppression of m ... | 2019 | 30904112 |
| overexpression of two members of d7 salivary genes family is associated with pyrethroid resistance in the malaria vector anopheles funestus s.s. but not in anopheles gambiae in cameroon. | d7 family proteins are among the most expressed salivary proteins in mosquitoes. they facilitate blood meal intake of the mosquito by scavenging host amines that induce vasoconstriction, platelet aggregation and pain. despite this important role, little information is available on the impact of insecticide resistance on the regulation of d7 proteins and consequently on the blood feeding success. in this study, real-time quantitative polymerase chain reaction (qpcr) analyses were performed to inv ... | 2019 | 30871094 |
| swarms of the malaria vector anopheles funestus in tanzania. | anopheles funestus mosquitoes currently contribute more than 85% of ongoing malaria transmission events in south-eastern tanzania, even though they occur in lower densities than other vectors, such as anopheles arabiensis. unfortunately, the species ecology is minimally understood, partly because of difficulties in laboratory colonization. this study describes the first observations of an. funestus swarms in tanzania, possibly heralding new opportunities for control. | 2019 | 30696441 |
| indoor residual spraying for preventing malaria in communities using insecticide-treated nets. | insecticide-treated nets (itns) and indoor residual spraying (irs) are used to control malaria vectors. both strategies use insecticides to kill mosquitoes that bite and rest indoors. for itns, the world health organization (who) only recommended pyrethroids until 2018, but mosquito vectors are becoming resistant to this insecticide. for irs, a range of insecticides are recommended. adding irs to itns may improve control, simply because two interventions may be better than one; it may improve ma ... | 2019 | 31120132 |
| risk factors for household vector abundance using indoor cdc light traps in a high malaria transmission area of northern zambia. | malaria transmission is dependent on the density and distribution of mosquito vectors, but drivers of vector abundance have not been adequately studied across a range of transmission settings. to inform intervention strategies for high-burden areas, further investigation is needed to identify predictors of vector abundance. active household (hh) surveillance was conducted in nchelenge district, luapula province, northern zambia, a high-transmission setting with limited impact of malaria control. ... | 2019 | 31074411 |
| involvement of anopheles nili in plasmodium falciparum transmission in north benin. | several studies carried out in benin have shown the involvement of anopheles gambiae sensu lato (s.l.), the anopheles funestus group in malaria transmission, but none of them reported the contribution of the anopheles nili group to the transmission of this disease. the current study investigated the question through an entomological cross-sectional survey performed in northern benin. | 2019 | 31036025 |
| dynamics and monitoring of insecticide resistance in malaria vectors across mainland tanzania from 1997 to 2017: a systematic review. | malaria still claims substantial lives of individuals in tanzania. insecticide-treated nets (itns) and indoor residual spray (irs) are used as major malaria vector control tools. these tools are facing great challenges from the rapid escalating insecticide resistance in malaria vector populations. this review presents the information on the dynamics and monitoring of insecticide resistance in malaria vectors in mainland tanzania since 1997. the information is important to policy-makers and other ... | 2019 | 30914051 |
| bio-efficacy and wash resistance of magnet long-lasting insecticidal net against wild populations of anopheles funestus in experimental huts in muheza, tanzania. | the decline in malaria cases and vectors is major milestone in fighting against malaria. the efficacy of magnet long-lasting insecticidal nets (magnet llin), an alpha-cypermethrin incorporated long-lasting net, with the target dose ± 25% of 5.8 g active ingredient (ai)/kg (4.35-7.25 g ai/kg) was evaluated in six veranda-trap experimental huts in muheza, tanzania against freely flying wild population of anopheles funestus. | 2019 | 31570107 |
| using a miniaturized double-net trap (dn-mini) to assess relationships between indoor-outdoor biting preferences and physiological ages of two malaria vectors, anopheles arabiensis and anopheles funestus. | effective malaria surveillance requires detailed assessments of mosquitoes biting indoors, where interventions such as insecticide-treated nets work best, and outdoors, where other interventions may be required. such assessments often involve volunteers exposing their legs to attract mosquitoes [i.e., human landing catches (hlc)], a procedure with significant safety and ethical concerns. here, an exposure-free, miniaturized, double-net trap (dn-mini) is used to assess relationships between indoo ... | 2019 | 31438957 |
| a chromosome-scale assembly of the major african malaria vector anopheles funestus. | anopheles funestus is one of the 3 most consequential and widespread vectors of human malaria in tropical africa. however, the lack of a high-quality reference genome has hindered the association of phenotypic traits with their genetic basis in this important mosquito. | 2019 | 31157884 |
| a marker of glutathione s-transferase-mediated resistance to insecticides is associated with higher plasmodium infection in the african malaria vector anopheles funestus. | metabolic resistance to insecticides is threatening malaria control in africa. however, the extent to which it impacts malaria transmission remains unclear. here, we investigated the association between a marker of glutathione s-transferase mediated metabolic resistance and plasmodium infection in field population of anopheles funestus s.s. in comparison to the a296s-rdl target site mutation. the 119f-gste2 resistant allele was present in southern (obout) (56%) and central (mibellon) (25%) regio ... | 2019 | 30962458 |
| escalation of pyrethroid resistance in the malaria vector anopheles funestus induces a loss of efficacy of piperonyl butoxide-based insecticide-treated nets in mozambique. | insecticide resistance poses a serious threat to insecticide-based interventions in africa. there is a fear that resistance escalation could jeopardize malaria control efforts. monitoring of cases of aggravation of resistance intensity and its impact on the efficacy of control tools is crucial to predict consequences of resistance. | 2019 | 30923819 |
| de novo profiling of rna viruses in anopheles malaria vector mosquitoes from forest ecological zones in senegal and cambodia. | mosquitoes are colonized by a large but mostly uncharacterized natural virome of rna viruses, and the composition and distribution of the natural rna virome may influence the biology and immunity of anopheles malaria vector populations. | 2019 | 31429704 |
| anopheline species composition and the 1014f-genotype in different ecological settings of burkina faso in relation to malaria transmission. | a three-year longitudinal study was conducted in four sentinel sites from different ecological settings in burkina faso, between 2008 and 2010 to identify longitudinal changes in insecticide resistance within anopheles gambiae complex species based on larval collection. during this study, adult mosquitoes were also collected indoor and outdoor using several methods of collection. the present study reports the diversity of malaria vectors and the 1014f-genotype from this adult collection and inve ... | 2019 | 31068189 |
| evolutionary superscaffolding and chromosome anchoring to improve anopheles genome assemblies. | new sequencing technologies have lowered financial barriers to whole genome sequencing, but resulting assemblies are often fragmented and far from 'finished'. updating multi-scaffold drafts to chromosome-level status can be achieved through experimental mapping or re-sequencing efforts. avoiding the costs associated with such approaches, comparative genomic analysis of gene order conservation (synteny) to predict scaffold neighbours (adjacencies) offers a potentially useful complementary method ... | 2020 | 31898513 |