| partial recovery of hemiparesis following hemispherectomy in infant monkeys. | hemiparesis, unilateral weakness or partial paralysis, is a common outcome following hemispherectomy in humans. we use the non-human primate as an invaluable translational model for our understanding of developmental plasticity in response to hemispherectomy. three infant vervet monkeys (chlorocebus sabeus) underwent hemispherectomy at a median age of 9 weeks and two additional monkeys at 48 months. gross motor assessment was conducted in a large open field that contained a horizontal bar spanni ... | 2010 | 19969043 |
| interaction of non-human primate complement and antibodies with hypermucoviscous klebsiella pneumoniae. | emergent hypermucoviscosity (hmv) phenotypes of klebsiella pneumoniae have been associated with increased invasiveness and pathogenicity in primates. in this study, we investigated the interaction of african green monkeys (agm) (chlorocebus aethiops sabaeus) complement and antibody with hmv and non-hmv isolates as in vitro models of primate infection. significantly greater survival of hmv isolates was evident after incubation in normal serum or whole blood (p < 0.05) of agm donors when compared ... | 2016 | 26951091 |
| biofilm formation of hypermucoviscous and non-hypermucoviscous klebsiella pneumoniae recovered from clinically affected african green monkey (chlorocebus aethiops sabaeus). | in recent years, an emergent klebsiella pneumoniae hypermucoviscous (hmv) phenotype has been associated with increased invasiveness and pathogenicity in primates. the hmv phenotype is characterized by different capsular serotypes, associated with several genes including the rmpa (regulator of mucoid phenotype) and maga (mucoviscosity-associated) genes. in african green monkeys (agm) (chlorocebus aethiops sabaeus) serotypes k1 and k5 have been implicated in fatal multisystemic abscesses. in order ... | 2017 | 28366827 |
| resistance of klebsiella pneumoniae to the innate immune system of african green monkeys. | in recent years, an emergent klebsiella pneumoniae hypermucoviscosity (hmv) phenotype has been associated with increased invasiveness and pathogenicity in primates. in this project, bacteria recovered from infected african green monkeys (agm) (chlorocebus aethiops sabaeus) were screened for hmv phenotype, and were compared to non-hmv isolates in in vitro, serum, and oxidative-mediated killing assays. complement-mediated killing was assessed utilizing freshly collected serum from healthy agm. oxi ... | 2015 | 25614101 |
| phenotypic and genotypic characterization of klebsiella pneumoniae isolates recovered from nonhuman primates. | klebsiella pneumoniae is a zoonotic, gram-negative member of the family enterobacteriaceae and is the causative agent of nosocomial septicemic, pneumonic, and urinary tract infections. recently, pathogenic strains of k. pneumoniae sharing a hypermucoviscosity (hmv) phenotype have been attributed to multisystemic abscessation in both human and nonhuman primates. although k. pneumoniae is a well-recognized zoonotic agent, there is a lack of general information including adequate diagnostic methods ... | 2012 | 22740526 |
| meaning attribution in the west african green monkey: influence of call type and context. | the search for the evolutionary roots of human language has fuelled much research into the cognitive mechanisms underlying communication in nonhuman animals. one core issue has been whether the context-specific calls of nonhuman animals are meaningful, with call meaning inferred from recipients' responses in the absence of supporting contextual cues. this direct inference may well offer an oversimplified view of how vocalisations are perceived, however, as responses under natural conditions are ... | 2014 | 23846397 |
| abdominal ultrasonography of the normal st. kitts vervet monkey (chlorocebus sabaeus). | normal ultrasonography of non-reproductive abdominal and male reproductive anatomy in the vervet monkey were prospectively assessed. this has not been previously reported. | 2013 | 23126241 |
| biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury. | tissue loss significantly reduces the potential for functional recovery after spinal cord injury. we previously showed that implantation of porous scaffolds composed of a biodegradable and biocompatible block copolymer of poly-lactic-co-glycolic acid and poly-l-lysine improves functional recovery and reduces spinal cord tissue injury after spinal cord hemisection injury in rats. here, we evaluated the safety and efficacy of porous scaffolds in non-human old-world primates (chlorocebus sabaeus) a ... | 2017 | 28167393 |
| the genome of the vervet (chlorocebus aethiops sabaeus). | we describe a genome reference of the african green monkey or vervet (chlorocebus aethiops). this member of the old world monkey (owm) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (siv), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in caribbean vervets (c. a. sabaeus), whose numbers have expanded dramatically since europeans introduced small numbers of their ancestors from west af ... | 2015 | 26377836 |
| expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus. | african green monkeys (agm) are amongst the most frequently used nonhuman primate models in clinical and biomedical research, nevertheless only few genomic resources exist for this species. such information would be essential for the development of dedicated new generation technologies in fundamental and pre-clinical research using this model, and would deliver new insights into primate evolution. | 2012 | 22726727 |
| limited geographic variation in the acoustic structure of and responses to adult male alarm barks of african green monkeys. | the global diversity of human languages is a remarkable feature of our species, which requires a capacity for rapid vocal learning. given that primate alarm calling systems have played an important role in the language origin debate, identifying geographic variation in primate alarm calls and understanding the underlying causal mechanisms are important steps to help uncover evolutionary precursors to language. this study investigates geographic variation in the alarm bark of the widely distribut ... | 2014 | 24771960 |
| barbados green monkeys (chlorocebus sabaeus) recognize ancestral alarm calls after 350 years of isolation. | vervet monkeys (chlorocebus pygerythrus) produce alarm calls and anti-predator behaviors that are specific to a threatening predator's mode of attack. upon hearing a leopard alarm, the monkeys will run up trees where they are relatively safe. in contrast, eagle alarms prompt the monkeys to run under bushes and snake alarms stimulate bipedal standing. early researchers proposed that the meaning of each alarm call is conveyed by observational learning. if this true then absence of the predator tha ... | 2013 | 24129028 |
| molecular characterization of a new mosaic simian immunodeficiency virus in a naturally infected tantalus monkey (chlorocebus tantalus) from cameroon: a challenge to the virus-host co-evolution of sivagm in african green monkeys. | african green monkeys (agms) represent the most widely distributed non-human primates species in africa. sivagm naturally infects four of the 6 agms species at high prevalence in a species-specific manner. to date, only limited information is available on molecular characteristics of sivagm infecting chlorocebus tantalus. here, we characterized the full-length genome of a virus infecting a naturally infected captive c. tantalus from cameroon by amplifying and sequencing sub-genomic pcr fragments ... | 2015 | 25500294 |
| transmission of staphylococcus aureus from humans to green monkeys in the gambia as revealed by whole-genome sequencing. | staphylococcus aureus is an important pathogen of humans and animals. we genome sequenced 90 s. aureus isolates from the gambia: 46 isolates from invasive disease in humans, 13 human carriage isolates, and 31 monkey carriage isolates. we inferred multiple anthroponotic transmissions of s. aureus from humans to green monkeys (chlorocebus sabaeus) in the gambia over different time scales. we report a novel monkey-associated clade of s. aureus that emerged from a human-to-monkey switch estimated to ... | 2016 | 27474712 |
| discordance between spatial distributions of y-chromosomal and mitochondrial haplotypes in african green monkeys ( chlorocebus spp.): a result of introgressive hybridization or cryptic diversity? | introgressive hybridization may cause substantial discordances among phylogenies based on different genetic markers. such discordances have been found in diverse mammal species including primates. a recent study of mitochondrial dna (mtdna) revealed several poly- and paraphyletic relationships in african green monkeys (chlorocebus), suggesting contemporary and/or ancient introgressive hybridization among almost all parapatric species of the genus. however, mtdna analyses alone do not allow us to ... | 2013 | 24098065 |
| first report of toxoplasma gondii seroprevalence in wild-caught caribbean african green monkeys. | toxoplasma gondii is a protozoan parasite capable of infecting all warm-blooded animals. humans can become infected by ingesting infective oocysts from the environment or contaminated food or water, or by ingesting tissue cysts in undercooked infected meat or by handling infected meat. caribbean african green monkeys (chlorocebus sabaeus) are present in large numbers on the island of st. kitts in the caribbean, and it is not uncommon for these animals to be trapped and eaten by islanders. the ai ... | 2014 | 25491011 |
| next generation sequencing (ngs) database for tandem repeats with multiple pattern 2°-shaft multicore string matching. | next generation sequencing (ngs) technologies have been rapidly applied in biomedical and biological research in recent years. to provide the comprehensive ngs resource for the research, in this paper , we have considered 10 loci/codi/repeats taga, tcat, gaat, agat, agaa, gata, tatc, cttt, tctg and tcta. then we developed the ngs tandem repeat database (tandemrepeatdb) for all the chromosomes of homo sapiens, callithrix jacchus, chlorocebus sabaeus, gorilla gorilla, macaca fascicularis, macaca m ... | 2016 | 26981434 |
| dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain. | neurofibrillary tangles (nft) and β-amyloid plaques are the neurological hallmarks of both alzheimer's disease and an unusual paralytic illness suffered by chamorro villagers on the pacific island of guam. many chamorros with the disease suffer dementia, and in some villages one-quarter of the adults perished from the disease. like alzheimer's, the causal factors of guamanian amyotrophic lateral sclerosis/parkinsonism dementia complex (als/pdc) are poorly understood. in replicated experiments, w ... | 2016 | 26791617 |
| inducible nitric oxide synthase (inos) regulatory region variation in non-human primates. | inducible nitric oxide synthase (inos) is an enzyme that plays a key role in intracellular immune response against respiratory infections. since various species of nonhuman primates exhibit different levels of susceptibility to infectious respiratory diseases, and since variation in regulatory regions of genes is thought to play a key role in expression levels of genes, two candidate regulatory regions of inos were mapped, sequenced, and compared across five species of nonhuman primates: african ... | 2015 | 25675838 |
| refinement of a protocol for the induction of lactation in nonpregnant nonhuman primates by using exogenous hormone treatment. | obtaining sufficient quantities of milk from nhp is necessary for pharmacologic and immunologic studies required for the development and safety assessment of drugs and vaccines to be used in the maternal-infant setting. we previously induced lactation in nonpregnant female rhesus macaques (rm, macaca mulatta) and african green monkeys (agm, chlorocebus sabaeus) for studies of immune responses in milk, but the volume collected was variable. to improve lactation induction protocols for nonbreeding ... | 2014 | 25650978 |
| standardized full-field electroretinography in the green monkey (chlorocebus sabaeus). | full-field electroretinography is an objective measure of retinal function, serving as an important diagnostic clinical tool in ophthalmology for evaluating the integrity of the retina. given the similarity between the anatomy and physiology of the human and green monkey eyes, this species has increasingly become a favorable non-human primate model for assessing ocular defects in humans. to test this model, we obtained full-field electroretinographic recordings (erg) and normal values for standa ... | 2014 | 25360686 |
| mhc polymorphism in caribbean african green monkeys. | african green monkeys (agm) are among the most widely used nonhuman primate models used in various fields of medical research. one species of agm that originated from west africa, chlorocebus sabaeus, was introduced three centuries ago in the caribbean islands. we present here a systematic study of the major histocompatibility complex (mhc) polymorphism of caribbean agm which is currently frequently used as an animal model. we studied 54 animals originated from barbados (n=25) or saint kitts (n= ... | 2014 | 24676686 |
| thoracic radiographic anatomy in vervet monkeys (chlorocebus sabaeus). | the vervet monkey (chlorocebus sabaeus) is used commonly in cardiorespiratory biomedical research. this study was performed to establish reference values for thoracic structures and to describe the normal radiographic appearance of the vervet monkey thorax. | 2013 | 23848259 |
| determination of fetal age by ultrasonography in st. kitts green monkeys. | ultrasound assessments of fetal growth have been used in other species of primates to estimate fetal age, but there are no published morphometrics for the st. kitts green monkey (chlorocebus sabaeus), a species that has been important for studies of transplantation of fetal tissue into the brain as potential treatment for degenerative disease. previous studies with other primate species have used relatively small numbers of pregnancies, measured repeatedly, to derive regressions for predicting f ... | 2012 | 22311723 |
| comparison of fresh to fixed weights of the vervet monkey (chlorocebus sabaeus) placenta and its relation to gestational age. | focus on the placenta as an agent of fetal development and offspring health outcomes is growing. primate research facilities or zoos may collect and fix placental tissue for long-term storage, but little is known about the effects of formalin fixation on the non-human primate placenta. | 2012 | 22296111 |
| an outbreak of yersinia enterocolitica in a captive colony of african green monkeys (chlorocebus aethiops sabaeus) in the caribbean. | yersinia enterocolitica is a zoonotic gram-negative pathogen that causes mesenteric lymphadenitis, terminal ileitis, acute gastroenteritis, and septicemia in domestic animals and primates. in 2012, 46 captive african green monkeys (chlorocebus aethiops sabaeus) died during an outbreak of acutely fatal enteric disease over a period of 1 mo on the island of st kitts. the affected monkeys presented with a history of mucohemorrhagic diarrhea, marked dehydration, and depression. fifteen bacterial iso ... | 2013 | 24210021 |
| convergent balancing selection on the mu-opioid receptor in primates. | the mu opioid receptor is involved in many natural processes including stress response, pleasure, and pain. mutations in the gene also have been associated with opiate and alcohol addictions as well as with responsivity to medication targeting these disorders. two common and mutually exclusive polymorphisms have been identified in humans, a118g (n40d), found commonly in non-african populations, and c17t (v6a), found almost exclusively in african populations. while a118g has been studied extensiv ... | 2017 | 28333316 |
| bloodfeeding patterns of sylvatic arbovirus vectors in southeastern senegal. | dengue (denv), yellow fever (yfv) and chikungunya (chikv) viruses circulate in sylvatic, enzootic transmission cycles in southeastern senegal, but understanding of the vector-host interactions involved is limited. | 0 | 23423342 |
| detection of picobirnaviruses in vervet monkeys (chlorocebus sabaeus): molecular characterization of complete genomic segment-2. | during 2014-2015, 270 fecal samples were collected from non-diarrheic, captive and wild african green monkeys (agms) on the island of st. kitts, caribbean region. by rna-page, picobirnaviruses (pbvs) were detected in sixteen captive agms. by rt-pcr and sequencing of partial gene segment-2, pbvs in 15 of these 16 samples were assigned to genogroup-i. the full-length nucleotide (nt) sequence of gene segment-2 of one of the genogroup-i pbv strains, strain pbv/african green monkey/kna/016593/2015, w ... | 2017 | 28057480 |
| scotopic vision in the monkey is modulated by the g protein-coupled receptor 55. | the endogenous cannabinoid system plays important roles in the retina of mice and monkeys via their classic cb1 and cb2 receptors. we have previously reported that the g protein-coupled receptor 55 (gpr55), a putative cannabinoid receptor, is exclusively expressed in rod photoreceptors in the monkey retina, suggesting its possible role in scotopic vision. to test this hypothesis, we recorded full-field electroretinograms (ergs) after the intravitreal injection of the gpr55 agonist lysophosphatid ... | 2016 | 27485069 |
| threats from the past: barbados green monkeys (chlorocebus sabaeus) fear leopards after centuries of isolation. | ability to recognize and differentiate between predators and non-predators is a crucial component of successful anti-predator behavior. while there is evidence that both genetic and experiential mechanisms mediate anti-predator behaviors in various animal species, it is unknown to what extent each of these two mechanisms are utilized by the green monkey (chlorocebus sabaeus). green monkeys on the west indies island of barbados offer a unique opportunity to investigate the underpinnings of anti-p ... | 2016 | 26910174 |
| asthma in an adult female vervet monkey (chlorocebus sabaeus). | a 9-y-old, colony-bred, female vervet monkey (chlorocebus sabaeus) presented with a 6-y history of open-mouth breathing, tachypnea, and sibilant wheezing. these symptoms did not significantly affect her activity or quality of life. thoracic radiographs and results of bronchoalveolar lavage supported the diagnosis of asthma. treatment comprising intramuscular prednisolone (tapered over 2 mo from twice daily to every other day), inhaled salmeterol-fluticasone (25 μg-250 μg per actuation twice dail ... | 2016 | 26884413 |
| a comparison of adult body size between captive and wild vervet monkeys (chlorocebus aethiops sabaeus) on the island of st. kitts. | weight and 34 morphological measurements were obtained from 103 vervet monkeys living either in the wild or in captive colonies derived from the wild populations on the island of st. kitts in the eastern caribbean. all measures were taken during the same week, eliminating bias that might result from changing seasonal environmental conditions. vervets on st. kitts are all descended from a small number of individuals brought to the island approximately 400 years ago from west africa, thus eliminat ... | 2016 | 26801341 |
| vitamin d heritability and effect of pregnancy status in vervet monkeys (chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. | the two objectives of the current study were to: 1) investigate the genetic contributions to variations in serum vitamin d concentrations under two dietary conditions (a standard monkey biscuit diet vs. a diet designed to model typical american consumption); and 2) explore the interaction of vitamin d with pregnancy status using a cohort of pedigreed female vervet/african green monkeys. | 2016 | 26708407 |
| measurement of hematological and serum biochemical normal values of captive housed chlorocebus aethiops sabaeus monkeys and correlation with the age. | some factors such as sex, age, and captivity conditions have a direct influence on the normal hematological and serum biochemical parameters of african green monkeys. on the other hand, reliability in reported values is in many cases limited by studied animal number (<200) and there is not report on the correlation of these parameters with the age in each sex animal group. thus, this study sought determining normal hematological (11) and serum biochemical parameters (9) of 400 captive housed afr ... | 2016 | 26647919 |
| variable responses of human and non-human primate gut microbiomes to a western diet. | the human gut microbiota interacts closely with human diet and physiology. to better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models, including non-human primates. however, due to unique aspects of human diet and physiology, it is likely that host-gut microbe interactions operate differently in humans and non-human primates. | 2015 | 26568112 |
| hematology and clinical chemistry measures during and after pregnancy and age- and sex-specific reference intervals in african green monkeys (chlorocebus aethiops sabaeus). | clinical decisions and experimental analyses often involve the assessment of hematology and clinical chemistry. using clinical pathology to assess the health status of nhp in breeding colonies or data from studies than involve pregnancy can often be complicated by pregnancy status. this study had 2 objectives regarding the hematology and clinical chemistry of african green monkeys (agm, chlorocebus aethiops sabaeus): 1) to compare pregnant or recently postpartum animals with nonpregnant, nonlact ... | 2015 | 26224434 |
| orchidectomy does not significantly affect spine synapse density in the ca3 hippocampal subfield in st. kitts vervet monkeys (chlorocebus aethiops sabaeus). | gonadal hormones induce significant changes in cognitive function, associated with alterations in the structure of the hippocampus. we have previously shown that androgens increase the number of spine synapses in the ca1 stratum radiatum of the monkey hippocampus. recent evidence, however, suggests that loss of testicular hormone production may have variable effects on neuroplasticity in different regions of the hippocampus. to test this hypothesis, we examined the effects of orchidectomy in the ... | 2014 | 24269983 |
| assessing the pulsatility of luteinizing hormone in female vervet monkeys (chlorocebus aethiops sabaeus). | specific alterations in the pulsatility of luteinizing hormone (lh) are linked to obesity-related subfertility in ovulatory women. vervet monkeys (chlorocebus aethiops sabaeus) are an old world nonhuman primate that develops obesity and has a menstrual cycle similar to humans. we evaluated follicular-phase lh pulses in 12 adult normal-weight female vervets. serum was collected every 10 min for 4 h by using a tether device in conscious, freely moving monkeys on menstrual cycle days 2 through 5. s ... | 2013 | 24210020 |
| effects of a western-type diet on plasma lipids and other cardiometabolic risk factors in african green monkeys (chlorocebus aethiops sabaeus). | our goal was to assess a nonhuman primate diet that mimicked the western-type diet of humans with regard to palatability and the diet's effects on plasma lipid concentrations and other cardiometabolic risk factors. we evaluated male (n = 8) and female (n = 11) african green monkeys (vervets; chlorocebus aethiops sabaeus) that initially were fed a standard diet. each cohort then was divided into 2 groups, which received either standard chow or the western diet. food consumption and fecal quality ... | 2013 | 23849442 |
| 25(oh)d3 and cardiovascular risk factors in female nonhuman primates. | to determine if interindividual differences in plasma concentrations of 25-hydroxyvitamin d(3) (25(oh)d(3)) have pathophysiologic significance, we evaluated a cohort of female monkeys, seeking to identify associations with clinically relevant cardiovascular risk factors, including age, abdominal obesity (waist circumference), and high-density lipoprotein cholesterol (hdl-c). | 2012 | 22876774 |
| population bottlenecks and pathogen extinction: "make this everyone's mission to mars, including yours". | kapusinszky et al. (j virol 89:8152-8161, 2015, http://dx.doi.org/10.1128/jvi.00671-15) report that host population bottlenecks may result in pathogen extinction, which provides a compelling argument for an alternative approach to vaccination for the control of virus spread. by comparing the prevalence levels of three viral pathogens in two populations of african green monkeys (agms) (chlorocebus sabaeus) from africa and two caribbean islands, they convincingly show that a major host bottleneck ... | 2015 | 26018162 |
| dual simian foamy virus/human immunodeficiency virus type 1 infections in persons from côte d'ivoire. | zoonotic transmission of simian retroviruses in west-central africa occurring in primate hunters has resulted in pandemic spread of human immunodeficiency viruses (hivs) and human t-lymphotropic viruses (htlvs). while simian foamy virus (sfv) and simian t- lymphotropic virus (stlv)-like infection were reported in healthy persons exposed to nonhuman primates (nhps) in west-central africa, less is known about the distribution of these viruses in western africa and in hospitalized populations. we s ... | 2016 | 27310836 |
| creating a simian model of guam als/pdc which reflects chamorro lifetime bmaa exposures. | the theory that β-n-methylamino-l-alanine (bmaa), a cyanobacterial toxin, contaminates traditional food supplies of the chamorro people of guam is supported by the recent finding that chronic dietary exposure to l-bmaa in vervets (chlorocebus sabaeus) triggers the formation of neurofibrillary tangles (nft) and β-amyloid plaques in the brain. in the first experiment, we found that all four vervets receiving a 210 mg/kg dose for 140 days developed nft and sparse amyloid deposits. in the second exp ... | 2017 | 28478528 |
| prenatal alcohol exposure affects progenitor cell numbers in olfactory bulbs and dentate gyrus of vervet monkeys. | fetal alcohol exposure (fae) alters hippocampal cell numbers in rodents and primates, and this may be due, in part, to a reduction in the number or migration of neuronal progenitor cells. the olfactory bulb exhibits substantial postnatal cellular proliferation and a rapid turnover of newly formed cells in the rostral migratory pathway, while production and migration of postnatal neurons into the dentate gyrus may be more complex. the relatively small size of the olfactory bulb, compared to the h ... | 2016 | 27801790 |
| effects of heated hydrotherapy on muscle hsp70 and glucose metabolism in old and young vervet monkeys. | increasing heat shock protein 70 (hsp70) in aged and/or insulin-resistant animal models confers benefits to healthspan and lifespan. heat application to increase core temperature induces hsps in metabolically important tissues, and preliminary human and animal data suggest that heated hydrotherapy is an effective method to achieve increased hsps. however, safety concerns exist, particularly in geriatric medicine where organ and cardiovascular disease commonly will preexist. we evaluated young ve ... | 2016 | 27188431 |
| uterine angioleiomyoma in an african green monkey (chlorocebus aethiops sabaeus). | a uterine neoplasm was observed, as an incidental finding, during post-mortem examination of a 26-year-old female multiparous african green monkey (chlorocebus aethiops sabaeus). the intramural, expansile, 2 to 3 cm well-demarcated, dark-red, nodular neoplasm was located on the anterior uterine body (corpus) wall. | 2017 | 27859319 |
| hematologic and biochemical ris for an aged population of captive african green monkeys (chlorocebus aethiops sabaeus). | established ris for geriatric african green monkeys (chlorocebus aethiops sabaeus) are critical for clinical differentiation of normal aging from disease-related changes in this population. | 2017 | 28543372 |
| müller cells express the cannabinoid cb2 receptor in the vervet monkey retina. | the presence of the cannabinoid receptor type 1 (cb1r) has been largely documented in the rodent and primate retinae in recent years. there is, however, some controversy concerning the presence of the cb2 receptor (cb2r) within the central nervous system. only recently, cb2r has been found in the rodent retina, but its presence in the primate retina has not yet been demonstrated. the aim of this study was twofold: 1) to characterize the distribution patterns of cb2r in the monkey retina and comp ... | 2013 | 23630038 |
| adaptive neuroplastic responses in early and late hemispherectomized monkeys. | behavioural recovery in children who undergo medically required hemispherectomy showcase the remarkable ability of the cerebral cortex to adapt and reorganize following insult early in life. case study data suggest that lesions sustained early in childhood lead to better recovery compared to those that occur later in life. in these children, it is possible that neural reorganization had begun prior to surgery but was masked by the dysfunctional hemisphere. the degree of neural reorganization has ... | 2012 | 22792495 |
| [the quantity and relationship of the axillary lymph nodes of the anterior extremities of the green marmoset (cercopithecus sabaeus)]. | | 1972 | 4633710 |
| blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: implications for a minimally invasive biomarker of mitochondrial health. | blood based bioenergetic profiling strategies are emerging as potential reporters of systemic mitochondrial function; however, the extent to which these measures reflect the bioenergetic capacity of other tissues is not known. the premise of this work is that highly metabolically active tissues, such as skeletal and cardiac muscle, are susceptible to differences in systemic bioenergetic capacity. therefore, we tested whether the respiratory capacity of blood cells, monocytes and platelets, are r ... | 2016 | 27693859 |
| high leptospira seroprevalence in captive and wild-caught vervet monkeys ( chlorocebus sabeus) on the caribbean island of saint kitts. | leptospirosis is a zoonotic disease of global importance. very little information is available on leptospira infection in nonhuman primates. we report herein a high seroprevalence (49.4%; 95% confidence interval: 41.6-57.2%) to leptospira serovars in vervet monkeys ( chlorocebus sabeus) on the caribbean island of saint kitts. monkeys bred in captivity ( n = 81) had a significantly higher seroprevalence compared to wild-caught monkeys ( n = 81; p < 0.05). seroprevalence to serovar bataviae was si ... | 2017 | 28782434 |
| sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits. | we report here the first genome-wide high-resolution polymorphism resource for non-human primate (nhp) association and linkage studies, constructed for the caribbean-origin vervet monkey, or african green monkey (chlorocebus aethiops sabaeus), one of the most widely used nhps in biomedical research. we generated this resource by whole genome sequencing (wgs) of monkeys from the vervet research colony (vrc), an nih-supported research resource for which extensive phenotypic data are available. | 2015 | 26092298 |
| characterization of ovarian aging and reproductive senescence in vervet monkeys (chlorocebus aethiops sabaeus). | female vervet monkeys (chlorocebus aethiops sabaeus) are used as an experimental model for chronic diseases relevant to women's health. however, reproductive senescence (menopause) has not yet been characterized for vervet monkeys. here we describe the histologic, hormonal, and menstrual markers of reproductive senescence in vervet monkeys from the wake forest vervet research colony. ovaries from monkeys (age, 0 to 27 y) were serially sectioned (5 μm), stained, and photographed. in every 100th s ... | 2014 | 24512962 |
| factors associated with siman immunodeficiency virus transmission in a natural african nonhuman primate host in the wild. | african green monkeys (agms) are naturally infected with simian immunodeficiency virus (siv) at high prevalence levels and do not progress to aids. sexual transmission is the main transmission route in agm, while mother-to-infant transmission (mtit) is negligible. we investigated siv transmission in wild agms to assess whether or not high siv prevalence is due to differences in mucosal permissivity to siv (i.e., whether the genetic bottleneck of viral transmission reported in humans and macaques ... | 2014 | 24623416 |
| a non-human primate system for large-scale genetic studies of complex traits. | non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. populations of caribbean vervet monkeys (chlorocebus aethiops sabaeus) are genetically homogeneous and large enough to permit well-powered genetic mapping studies of quantitative traits relevant to human health, including expression quantitative trait loci (eqtl). previous transcriptome-wide investigation in an extended vervet pedigree identified 29 heritable transcripts ... | 2012 | 22556363 |
| significant genotype by diet (g × d) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (chlorocebus aethiops sabaeus). | nutrient composition of a diet (d) has been shown to interact with genetic predispositions (g) to affect various lipid phenotypes. our aim in this study was to confirm g × d interaction and determine whether the interaction extends to other cardiometabolic risk factors such as glycemic measures and body weight. subjects were vervet monkeys (chlorocebus aethiops sabaeus; n = 309) from a multigenerational pedigreed colony initially fed with a plant-based diet, standard primate diet (18% calories f ... | 2013 | 23315630 |
| conserved alarm calls but rapid auditory learning in monkey responses to novel flying objects. | to evaluate the flexibility in vocal production and comprehension in a non-human primate, we presented a drone to west african green monkeys, chlorocebus sabaeus. calls given in response to the drone were clearly distinct from those given to other predators, but highly similar to the aerial alarm calls of the east african vervet monkey, chlorocebus pygerythrus, suggesting that call structure is conserved. to probe how rapidly the animals attached meaning to the sound of the drone, we played back ... | 2019 | 31133723 |
| should monkeys wash their hands and feet: a pilot-study on sources of zoonotic parasite exposure. | human exposure to zoonotic parasites via contaminated soil is a much studied area. less research has been performed on exposure via contact with animals and surfaces such as picnic tables with which infected animals might be in contact. on st. kitts, wild african green monkeys (agm; chlorocebus aethiops sabaeus), which are known to have zoonotic parasites, roam freely in areas with outdoor dining facilities and are used in the tourist industry. in this study, the hands and feet of eight agm and ... | 2019 | 30963089 |
| decreased antibiotic susceptibility driven by global remodeling of the klebsiella pneumoniae proteome. | bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. here we examine antibiotic susceptibility with a class a β-lactamase+ invasive strain of klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of chlorocebus aethiops sabaeus monkeys. bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in dist ... | 2019 | 30617156 |
| greater microbial translocation and vulnerability to metabolic disease in healthy aged female monkeys. | monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (mt) and inflammation with ageing despite equivalent health status, and lifelong diet and environmental conditions. we evaluated colonic structural, microbiomic and functional changes in old female vervet monkeys (chlorocebus aethiops sabeus) and how age-related leaky gut alters responses to western diet. we additionally assessed serum bovine immunoglobulin therapy to ... | 2018 | 30054517 |
| signature microrna expression profile is associated with spontaneous hypertension in african green monkey. | chlorocebus aethiops sabaeus, the african green monkey (agm), has been proved to exhibit renal vascular remodeling and spontaneous hypertension. however, little is known about the roles of micrornas (mirnas) in this process.using small rna deep sequencing, we compared the plasma mirna expression patterns between hypertensive (ht) agms and normotensive (nt) agms. expression of mirnas (mir-122, mir-339, mir-296-5p) was validated independently in plasma samples from 10 ht agms and 10 nt agms (fold ... | 2019 | 29787292 |
| identity construction and symbolic association in farmer-vervet monkey (chlorocebus aethiops sabaeus) interconnections in st. kitts. | primates occupy a liminal space between humans and animals. on the caribbean island of st. kitts, translocated vervet monkeys (chlorocebus aethiops sabaeus) are respected creatures, yet they cause problems. vervets regularly consume crops on farms and are considered "pests"; still, kittitians express empathy and understanding for them based largely on the monkeys' display of human-like behaviours. using data from interviews with 64 kittitian farmers, we deconstruct the symbolism of the vervet mo ... | 2018 | 29631262 |
| neurodegenerative disease biomarkers aβ1-40, aβ1-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: relation to normal aging, genetic influences, and cerebral amyloid angiopathy. | the caribbean vervet monkey (chlorocebus aethiops sabaeus) is a potentially valuable animal model of neurodegenerative disease. however, the trajectory of aging in vervets and its relationship to human disease is incompletely understood. | 2018 | 29484263 |
| molecular species identification of trichuris trichiura in african green monkey on st. kitts, west indies. | the population of african green monkeys (agm, chlorocebus aethiops sabaeus) on st. kitts, west indies is believed to be as large as or greater than the human population. interactions with humans are frequent and the pathogens carried by agm, such as trichuris spp., may pose a risk to humans. the objectives of this study were to assess the use of molecular methods for diagnosing trichuris spp. in agm and compare its dna sequences to those of trichuris spp. found in other non-human primates and hu ... | 2018 | 31014613 |
| st. kitts green monkeys originate from west africa: genetic evidence from feces. | sequencing of a fragment of mitochondrial dna extracted from droppings of a green monkey inhabiting the caribbean island of st. kitts, and comparing the obtained sequence with sequences determined earlier for the four recognized subspecies of african green monkeys, showed that this monkey can be classified as cercopithecus aethiops sabaeus, and thus originates from west africa. as the ancestors of the monkeys reached the island by ships involved in the slave trade in the 17th to 18th centuries, ... | 1996 | 31918521 |
| personality features in vervet monkeys: the effects of sex, age, social status, and group composition. | personality ratings were completed in 97 socially living vervet monkeys (cercopithecus aethiops sabaeus) ranging in age from 19 months to 14 years. monkeys were rated on 17 distinct items on three separate occasions over a 14 month period. for each rating session, factor analysis resulted in similar factors: socially competent, playful/curious, and opportunistic, which are provisionally labeled as personality features. individuals' scores on the three factors were linked to the subjects' social ... | 1994 | 31936927 |
| twinning in a colony of vervet monkeys (cercopithecus aethiops sabaeus). | from 1975 through 1991, three sets of twins were born from a total of 693 live and stillborn births (0.43%) at the ucla/sepulveda veterans administration medical center nonhuman primate research laboratory, ca. none of the twin's mothers were related. positive patrilineal relationships have not been established; however, a brother (not a twin) of the first set of twins may have fathered the third set. all twins were born to multiparous females and, in each case, only one infant survived beyond 4 ... | 1994 | 31936905 |
| type-2-diabetes alters csf but not plasma metabolomic and ad risk profiles in vervet monkeys. | epidemiological studies suggest that individuals with type 2 diabetes (t2d) have a twofold to fourfold increased risk for developing alzheimer's disease (ad), however, the exact mechanisms linking the two diseases are unknown. in both conditions, the majority of pathophysiological changes, including glucose and insulin dysregulation, insulin resistance, and ad-related changes in aβ and tau, occur decades before the onset of clinical symptoms and diagnosis. in this study, we investigated the rela ... | 2019 | 31555072 |
| identification of a novel simian immunodeficiency virus-infected african green monkey (chlorocebus tantalus) confirms that tantalus monkeys in cameroon are infected with a mosaic sivagm lineage. | in this study we report on the identification of a simian immunodeficiency virus (siv) infecting a chlorocebus tantalus from cameroon. the isolate, sivagmtan-ca1, was molecularly characterized by sequencing partial genome (∼4,000 bp) using the conventional sanger method and the oxford nanopore technology (ont). in pol and gp41/nef sivagmtan-ca1 clusters with sivagmsab infecting chlorocebus sabaeus from west africa, whereas in env-gp120 it clusters with sivagmtan infecting c. tantalus from centra ... | 2020 | 31547667 |
| extraintestinal acanthocephalan oncicola venezuelensis (oligacanthorhynchidae) in small indian mongooses (herpestes auropunctatus) and african green monkeys (chlorocebus aethiops sabaeus). | we identified multiple extraintestinal cystacanths during routine postmortem examination of 3 small indian mongooses and 2 african green monkeys from the caribbean island of st. kitts. in mongooses, cystacanths were encysted or free in the subcutaneous tissue, skeletal muscle, or peritoneal or pericardial cavities, whereas in the monkeys, they were in the cavity and parietal layer of the, tunica vaginalis, skeletal muscle, and peritoneal cavity. morphological, histological, and molecular charact ... | 2019 | 31170895 |
| generation of pluripotent stem cells using somatic cell nuclear transfer and induced pluripotent somatic cells from african green monkeys. | patient-specific stem cells derived from somatic cell nuclear transfer (scnt) embryos or from induced pluripotent stem cells (ipscs) could be used to treat various diseases with minimal immune rejection. many studies using these cells have been conducted in rats and mice; however, there exist numerous dissimilarities between the rodents and humans limiting the clinical predictive power and experimental utility of rodent experiments alone. nonhuman primates (nhps) share greater homology to human ... | 2020 | 32715987 |
| non-human primate determinants of natural killer cells in tissues at steady-state and during simian immunodeficiency virus infection. | natural killer (nk) cells play essential roles in immunity to viruses and tumors. their function is genetically determined but also modulated by environmental factors. the distribution and functional regulation of these cells vary depending on the tissue. nk cell behavior in lymphoid tissues is so far understudied. non-human primate (nhp) models are essential for the development of therapies and vaccines against human diseases, and access to nhp tissues allows insights into spatial regulations o ... | 2020 | 33013901 |
| midazolam as an effective intravenous adjuvant to prolonged ketamine sedation in young rhesus (macaca mulatta) and vervet (cercopithecus aethiops sabaeus) monkeys: a preliminary report. | the present study investigated a recently developed benzodiazepine, midazolam, as an intravenous adjuvant to ketamine in infant monkeys undergoing prolonged sedation during positron emission tomography of the brain and heart. subjects were two rhesus macaque (macaca mulatta) and ten vervet monkeys (cercopithecus aethiops sabaeus) ranging in age from 26 to 260 days. midazolam was an effective intravenous adjuvant to ketamine. this treatment regime resulted in complete immobilization of the animal ... | 1993 | 31941185 |
| maternal protectiveness and response to the unfamiliar in vervet monkeys. | vervet monkeys (cercopithecus aethiops sabaeus) show individual differences in approach-avoidance behavior when faced with an unfamiliar and potentially threatening situation. prior research from our colony demonstrated that juveniles who had experienced high levels of early maternal protectiveness were more cautious in response to novelty, compared to juveniles who had had less protective mothers. the research reported here was designed to verify this result in a paradigm that experimentally va ... | 1993 | 31937015 |
| biomarkers of senescence in non-human primate adipose depots relate to aging. | forty-three female african green monkeys (chlorocebus aethiops sabaeus) were selected to represent young adult to advanced geriatric ages (7-24 years) to exhibit a wide range of obesity status (8-53% body fat) and diverse metabolic syndrome criteria such as diabetes, dyslipidemia, and hypertension. subcutaneous and visceral adipose tissues were collected and evaluated for the presence of senescence cells in both whole tissue and single-cell isolates from subcutaneous sources, utilizing senescenc ... | 2020 | 32705409 |
| leptospira infections in domestic and wild animals. | leptospirosis is a worldwide-distributed, re-emerging zoonosis due to the large variety of wild and domestic animal species that can play the role of natural or accidental host. currently, specific animal species play an important role as the reservoir for particular leptospira serovars, although recent investigations have highlighted new host-pathogen interactions involved in leptospira epidemiology. furthermore, the constant modification of ecosystems and wildlife habitats and the constantly i ... | 2020 | 32679834 |
| advanced maternal age impacts physiologic adaptations to pregnancy in vervet monkeys. | the trend to delay pregnancy in the usa has resulted in the number of advanced maternal age (ama) pregnancies to also increase. in humans, ama is associated with a variety of pregnancy-related pathologies such as preeclampsia (pe). while ama is known to be a factor which contributes to the development of pregnancy-induced diseases, the molecular and cellular mechanisms giving rise to this phenomenon are still very limited. this is due in part to lack of a preclinical model which has physiologic ... | 2020 | 32588342 |
| rank, relationships, and responses to intruders among adult male vervet monkeys. | we examined the influences of dyadic relationships among captive adult male vervet monkeys (cercopithecus aethiops sabaeus) on behavior directed toward caged "intruder" males placed inside subjects' enclosures. subjects were all 9 adult male residents from three stable social groups, each of which contained 3 adult males, at least 3 adult females, and their immature offspring. every male was observed in two 3-hour sessions, each time with one of the 2 other adult males from his group. observatio ... | 1993 | 31937002 |
| spectral sensitivity of vervet monkeys (cercopithecus aethiops sabaeus) and the issue of catarrhine trichromacy. | several genera of platyrrhine monkeys show significant polymorphism of color vision. by contrast, catarrhine monkeys have usually been assumed to have uniform trichromatic color vision. however, the evidential basis for this assumption is quite limited. to study this issue further, spectral sensitivity functions were obtained from vervet monkeys (cercopithecus aethiops sabaeus) using the technique of electroretinographic flicker photometry. results from a chromatic adaptation experiment indicate ... | 1991 | 31952406 |
| identification of schistosoma mansoni infection in a nonhuman primate from st. kitts more than 50 years after interruption of human transmission. | transmission of schistosoma mansoni was interrupted on st. kitts, a caribbean island, in the 1950s. with no reported cases since that time and most biomphalaria spp. snail populations eliminated based on surveys in the 1970s, s. mansoni has been considered eliminated on st. kitts. in 2019, s. mansoni eggs were found in an african green monkey (chlorocebus aethiops sabaeus) that originated from st. kitts. nonhuman primate (nhp) infections have been considered incidental to human infections, with ... | 2020 | 32996451 |
| no evidence for sylvatic cycles of chikungunya, dengue and zika viruses in african green monkeys (chlorocebus aethiops sabaeus) on st. kitts, west indies. | dengue, chikungunya and zika viruses (denv, chikv and zikv) are transmitted in sylvatic transmission cycles between non-human primates and forest (sylvan) mosquitoes in africa and asia. it remains unclear if sylvatic cycles exist or could establish themselves elsewhere and contribute to the epidemiology of these diseases. the caribbean island of st. kitts has a large african green monkey (agm) (chlorocebus aethiops sabaeus) population and is therefore ideally suited to investigate sylvatic cycle ... | 2020 | 33126907 |
| determinants of fecundity and reproductive success in captive vervet monkeys. | between 1975 and 1983, adult female vervet monkeys (cercopithecus aethiops sabaeus) over 3.5 years of age, living in two undisturbed social groups in a captive colony in sepulveda, california, have averaged 1.0 births per female year with a mean interbirth interval of 10.7 months. increased fecundity did not result in decreased survival rates of offspring in this population. fecundity was influenced by the mother's age and dominance rank. the primary factor in the age-fecundity relationship was ... | 1984 | 32138459 |
| renal vascular and glomerular pathologies associated with spontaneous hypertension in the nonhuman primate chlorocebus aethiops sabaeus. | hypertension is a complex, multifactorial disease affecting an estimated 78 million adults in the united states. despite scientific gains, the etiology of human essential hypertension is unknown and current experimental models do not recapitulate all the behavioral and physiological characteristics of the pathology. researchers should assess the translational capacity of these models and look to other animal models for the discovery of new therapies. chlorocebus aethiops sabaeus, the african gre ... | 2017 | 28659284 |
| female mate choice in vervet monkeys (cercopithecus aethiops sabaeus). | female mate choice was examined in a captive group of vervet monkeys (cercopithecus aethiops sabaeus). male-female interactions were examined under both dyadic and group conditions to determine whether females mate with different males under the two conditions. results showed that all females preferred to mate with the alpha male under both dyadic and group conditions. alpha females, however, were more successful than subordinate females in rejecting the sexual solicitations of subordinate males ... | 1986 | 31979492 |
| epidemic of venereal treponematosis in wild monkeys: a paradigm for syphilis origin. | treponema pallidum infections have been primarily known as slightly contagious mucocutaneous infections called yaws (tropical africa and america) and bejel (subtropical north africa). t. pallidum emerged as a highly infectious venereal syphilis agent in south america, probably about 500 years ago, and because of its venereal transmission, it quickly caused a worldwide pandemic. the disease manifests as lesions, including a chancre; then antibodies become detectable when or slightly after the cha ... | 2020 | 32368345 |
| discrimination of the effects of three cardiac ion channel blockers using ecg biomarkers and arrhythmia incidence in st. kitts green monkeys (chlorocebus sabaeus). | | 2020 | 31963047 |
| synergistic effects of cisplatin-caffeic acid induces apoptosis in human cervical cancer cells via the mitochondrial pathways. | cervical cancer (cxca) is a major health problem globally and is associated with the presence of human papillomavirus infection. cisplatin (cddp) is a platinum-based chemotherapeutic agent. owing to its side effects and drug-resistance, novel anticancer agents with lower toxicity, including caffeic acid (cfc), are of interest. however, the effects of cddp and cfc in combination are, to the best of our knowledge, uninvestigated. the present study investigated the effectiveness of cddp and cfc in ... | 2018 | 29731891 |
| genomic diversity of escherichia coli isolates from non-human primates in the gambia. | increasing contact between humans and non-human primates provides an opportunity for the transfer of potential pathogens or antimicrobial resistance between host species. we have investigated genomic diversity and antimicrobial resistance in escherichia coli isolates from four species of non-human primates in the gambia: papio papio (n=22), chlorocebus sabaeus (n=14), piliocolobus badius (n=6) and erythrocebus patas (n=1). we performed illumina whole-genome sequencing on 101 isolates from 43 sto ... | 2020 | 32924917 |
| acute changes in social composition and agonistic behavior in male vervet monkeys (cercopithecus aethiops sabaeus). | among nonhuman primates the composition of social groups influences the interactions of group members. we assessed the effects of acute changes in social composition on behavior among 15 adult male vervet monkeys (cercopithecus aethiops sabaeus). subjects were observed in their basal social groups which comprised 3 adult males, 2-4 adult females, and offspring; and in two subgroups consisting of either two or three adult males. agonism and vigilance increased in smaller groups relative to basal ... | 1992 | 31948137 |
| effects of trapping on the vervet (cercopithecus aethiops sabaeus) population in barbados. | the effects of a 7-year trapping program on a population of vervets, cercopithecus aethiops sabaeus, in barbados is described. the pretrapping population was estimated at between 6,000 and 12,000 monkeys. the number trapped annually has increased from less than 200 in 1980 to almost 1,000 in 1986. despite this, annual catch per trapping effort indicates that population abundance has remained relatively constant. however, the proportion of juveniles to adults in the population has increased marke ... | 1988 | 31968894 |
| effects of prenatal alcohol exposure on the visual system of monkeys measured at different stages of development. | fetal alcohol spectrum disorder (fasd) is a developmental disease characterized by behavioral problems and physical defects including malformations of the eye and associated optical defects. how these malformations affect retinal functioning is not well known, although animal models have suggested that scotopic vision is particularly deficient. age is also known to affect scotopic vision. here, we determined the combined effects of age and fetal alcohol exposure (fae) on retinal function using f ... | 2017 | 29242902 |
| expression and localization of cb1r, nape-pld, and faah in the vervet monkey nucleus accumbens. | extensive rodent literature suggests that the endocannabinoid (ecb) system present in the nucleus accumbens (nac) modulates dopamine (da) release in this area. however, expression patterns of the cannabinoid receptor type 1 (cb1r), the synthesizing enzyme n-acyl phosphatidylethanolamine phospholipase d (nape-pld), and the degradation enzyme fatty acid amide hydrolase (faah) in the nac have not yet been described in non-human primates. the goal of this study is therefore to characterize the expre ... | 2018 | 29875385 |
| obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the african green monkey (chlorocebus aethiops sabaeus). | in humans, the ontogeny of obesity throughout the life course and the genetics underlying it has been historically difficult to study. we compared, in a non-human primate model, the lifelong growth trajectories of obese and non-obese adults to assess the heritability of and map potential genomic regions implicated in growth and obesity. | 2017 | 29211707 |
| enhancing viral vaccine production using engineered knockout vero cell lines - a second look. | the global adoption of vaccines to combat disease is hampered by the high cost of vaccine manufacturing. the work described herein follows two previous publications (van der sanden et al., 2016; wu et al., 2017) that report a strategy to enhance poliovirus and rotavirus vaccine production through genetic modification of the vero cell lines used in large-scale vaccine manufacturing. crispr/cas9 gene editing tools were used to knockout vero target genes previously shown to play a role in polio- an ... | 2018 | 29555218 |
| time-course transcriptome analysis of host cell response to poxvirus infection using a dual long-read sequencing approach. | in this study, we applied two long-read sequencing (lrs) approaches, including single-molecule real-time and nanopore-based sequencing methods to investigate the time-lapse transcriptome patterns of host gene expression as a response to vaccinia virus infection. transcriptomes determined using short-read sequencing approaches are incomplete because these platforms are inefficient or fail to distinguish between polycistronic rnas, transcript isoforms, transcriptional start sites, as well as trans ... | 2021 | 34167576 |
| adenovirus infections in african humans and wild non-human primates: great diversity and cross-species transmission. | non-human primates (nhps) are known hosts for adenoviruses (advs), so there is the possibility of the zoonotic or cross-species transmission of advs. as with humans, adv infections in animals can cause diseases that range from asymptomatic to fatal. the aim of this study was to investigate the occurrence and diversity of advs in: (i) fecal samples of apes and monkeys from different african countries (republic of congo, senegal, djibouti and algeria), (ii) stool of humans living near gorillas in ... | 2020 | 32570742 |
| transcriptomic analysis of cell-free fetal rna in the amniotic fluid of vervet monkeys (chlorocebus sabaeus). | nhp are important translational models for understanding the genomic underpinnings of growth, development, fetal programming, and predisposition to disease, with potential for the development of early health biomarkers. understanding how prenatal gene expression is linked to pre- and postnatal health and development requires methods for assessing the fetal transcriptome. here we used rnaseq methodology to analyze the expression of cell-free fetal rna in the amniotic fluid supernatant (afs) of ve ... | 2020 | 31969210 |
| l-serine reduces spinal cord pathology in a vervet model of preclinical als/mnd. | the early neuropathological features of amyotrophic lateral sclerosis/motor neuron disease (als/mnd) are protein aggregates in motor neurons and microglial activation. similar pathology characterizes guamanian als/parkinsonism dementia complex, which may be triggered by the cyanotoxin β-n-methylamino-l-alanine (bmaa). we report here the occurrence of als/mnd-type pathological changes in vervets (chlorocebus sabaeus; n = 8) fed oral doses of a dry powder of bmaa hcl salt (210 mg/kg/day) for 140 d ... | 2020 | 32077471 |