Publications

[factors influencing the production of chinese yam (dioscorea batatas decne.)].		1987	2835189
allergic contact dermatitis from dioscorea batatas decaisne.		1988	3365956
occupational asthma caused by two herb materials, dioscorea batatas and pinellia ternata.	there have been very few cases of occupational allergies caused by herb materials. in this paper, we report a case of occupational asthma and rhinitis caused by two herb materials, dioscorea batatas and pinellia ternata, which are known as sanyak and banha respectively. the patient had strong positive responses to grass pollens and cat fur, as well as to sanyak and banha extracts on skin-prick tests. bronchoprovocation tests showed a dual asthmatic response to sanyak whereas only an early asthma ...	1994	7922777
[a new subtype of potato class i patatin gene].	potato class i and class ii patatin gene belong to a multigene family with different tissuespecific expression patterns. a class i patatin gene was isolated from a genomic library of chinese potato cultivar "dongnong 303" (solanum tuberosum) by using class ii patatin promoter as probe. a 1.8kp dna sequence was determined, including 1407bp of patatin gene 5' flanking sequence and 363bp of patatin structure gene. its 5' flanking sequence showed that it is a class i patatin gene. compared with six ...	1997	9494296
dioscorin, the major tuber storage protein of yam (dioscorea batatas decne) with carbonic anhydrase and trypsin inhibitor activities.	dioscorin, the tuber storage protein of yam (dioscorea batatas decne), was purified successively by ammonium sulfate fractionation, de-52 ion exchange chromatography, and sephadex g-75 column. two protein bands (82 and 28 kda) were found under nonreducing conditions after sds-page; but only one band (32 kda) was detected under reducing conditions. the first 21 amino acids in the n-terminal region of the 28 kda form were vedefsyiegnpngpenwgnl, which was highly homologous to deductive sequence of ...	1999	10552514
antioxidant activities of dioscorin, the storage protein of yam (dioscorea batatas decne) tuber.	dioscorin, the storage protein of yam (dioscorea batatas decne) tuber (which is different from dioscorine found in tubers of dioscorea hirsuta), was purified to homogeneity after de-52 ion exchange column according to the methods of hou et al. (j. agric. food chem. 1999, 47, 2168-2172). a single band of 32 kda dioscorin was obtained on a sodium dodecyl sulfate-polyacrylamide gel electrophoresis gel with 2-mercaptoethanol treatment. this purified dioscorin was shown by spectrophotometric method t ...	2001	11600050
the 3'-terminal sequence of chinese yam necrotic mosaic virus genomic rna: a close relationship with macluravirus.	the nucleotide sequence of the 3'-terminal 1,905 residues of the chinese yam necrotic mosaic virus (chynmv) rna genome was determined. it contains one long open reading frame, which consists of 1,671 nucleotides encoding a protein of 557 amino acid residues. a partial amino acid sequence of the coat protein determined from purified chynmv particles was identical to the portion of the amino acid sequence deduced from the determined nucleotide sequence, which suggests that the nucleotide sequence ...	2001	11676415
effects of "chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.	to study the effect of yam in taiwan, which is a commonly used chinese medicine, on hepato-nephro-toxicity in rats.	2002	12060523
enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage.	yam (dioscorea batatas) mucopolysaccharide (ymp) was examined for the ability to induce secretory and cellular responses in murine peritoneal macrophages. when macrophages were treated with various doses (10-100 microg/ml) of ymp for 48 h, a significant cytotoxicity against b 16 cells was observed. ymp also increased the myeloperoxidase activity and the production of h(2)o(2), o(2)(-), nitric oxide (no) and tumor necrosis factor (tnf-alpha). however, there was a little alteration on the producti ...	2002	12490222
yam (dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro.	the yam (dioscorea batatas decne) tuber mucilage (ytm) was extracted and partially purified by sds and heating treatments. this purified ytm exhibited antioxidant activities in a series of in vitro tests, including 1,1-diphenyl-2-picrylhydrazyl (dpph) radical (half-inhibition concentration, ic 50, was 0.86 mg/ml) and hydroxyl radical (ic 50 was 22 microg/ml) scavenging activity assays, reducing power test, anti-lipid peroxidation and anti-human low density lipoprotein peroxidation tests (ic 50 w ...	2002	12494332
the evaluation of reno- and hepatoprotective effects of huai-shan-yao (rhizome dioscoreae).	huai-shan-yao (chinese yam; rhizome dioscoreae) is a common food in china. in the present study, we evaluated the protective effects of the crude extract of huai-shan-yao on acute kidney and liver injuries in rats induced by ethanol. results of pharmacological, biochemical and pathologic observations all showed that rats treated with the extract of huai-shan-yao had decreased damage in renal tubules as well as decreased inflammation in the central vein and necrosis in the liver tissue.	2002	12568288
molecular evidence that aphid-transmitted alpinia mosaic virus is a tentative member of the genus macluravirus.	alpinia mosaic virus (alpmv), once assigned to the genus potyvirus, infects primarily plants of the ginger family. to seek molecular evidence for correct classification of this virus, a cdna clone corresponding to the 3' portion of the alpmv genome was obtained by reverse transcriptase-pcr and ta cloning. the authenticity of the cdna clone was confirmed by expression of the coat protein (cp) in e. coli followed by immunoblot analysis. sequence analysis indicated that, in contrast to its low iden ...	2003	12756625
pregnancy in premature ovarian failure after therapy using chinese herbal medicine.	we present ovulation that occurred after the administration of traditional chinese herbal medicine for 3 months in a woman with premature ovarian failure (pof) and secondary amenorrhea for 8 years. traditional chinese medicine concentrated herbal extracts of cooked rehmannia, chinese yam, wolfberry fruit, dogwood fruit, cyathula root, dodder seed, antler glue, tortoise-plastron glue, epimedium and morinda root were prescribed, which were a modification of the herbal formula zuo-gui-wan. when the ...	2003	12956293
[effect of dandi tablet on blood lipids and sex hormones in women of postmenopausal stage].	to explore the effect of dandi tablet (ddt), a tcm preparation for tonifying shen and activating blood circulation, on blood lipids and sex hormones in women of postmenopausal stage.	2003	14503058
chinese yam (dioscorea alata cv. tainung no. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats.	antioxidative effects of dioscorea alata (d. alata) were investigated in hyperhomocysteinemia (hhcy) induced by methionine (met) oral feeding (1 (g/kg of bw)/day). hhcy rats were fed a standard laboratory chow supplemented without or with freeze-dried d. alata powder at 1, 2.5, and 5 (g/kg of bw)/day, assigned as met, met + d1, met + d2, and met + d3 groups, respectively. twelve weeks after d. alata feeding, plasma homocysteine levels (16.3-24.2 microm) were significantly decreased compared to t ...	2004	15030236
immune cell stimulating activity of mucopolysaccharide isolated from yam (dioscorea batatas).	mucopolysaccharide (ymp) of yam (dioscorea batatas decne) was tested for immunomodulatory activity in vitro. we examined the effect of ymp on the viability, cell-mediated cytotoxicity and ifn-gamma secretion of splenic lymphocytes. the cytotoxic activity of mouse splenocyte against leukemia cell was increased in the presence of ymp (10 microg/ml). however, ymp (10 microg/ml) did not affect the viability of splenocytes. the production of ifn-gamma was significantly increased in the ymp treated sp ...	2004	15036459
characterization of the yam tuber storage proteins from dioscorea batatas exhibiting unique lectin activities.	four major proteins designated db1, db2, db3, and db4 were isolated and characterized from the yam tuber dioscorea batatas. the ratios of their yields were 20:50:20:10. db1 was a mannose-binding lectin (20 kda) consisting of 10-kda subunits and was classified as the monocot mannose-binding lectin family. db2, accounting for 50% of the total protein, was the storage protein, commonly called dioscorins consisting of a 31-kda subunit. on the basis of amino acid sequence, db2 was classified to be di ...	2004	15047697
screening of korean herbal medicines used to improve cognitive function for anti-cholinesterase activity.	methanolic extracts of seven herbs (acorus calamus, acorus gramineus, bupleurm facaltum, dioscorea batatas, epimedium koreanum, poria cocos and zizyphi jujuba) used in traditional korean medicine for improvement of memory and cognition in old age were tested for cholinesterase inhibitory properties using the ellman colorimetric method. significant inhibition of the enzyme at 200 microg/ml was observed for extracts from a. calamus and e. koreanum. the possible bases for the reputation of these an ...	2004	15500267
new starches from traditional chinese medicine (tcm)--chinese yam (dioscorea opposita thunb.) cultivars.	the starches separated from two different dioscorea opposita thunb. cultivars were investigated for morphological, thermal and crystal properties. the shape of starch granules separated from different d. opposita thunb. cultivars varied from round to oval or irregular. the surface of the starch granules appeared to be smooth without any fissures. the average particle diameter of starches from different d. opposita thunb. cultivars was 40.3 and 38.7mum for d. 47 and d. sxy starch, respectively. t ...	2006	16325789
monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin k and antiinflammation agent--monascin.	monacolin k, an inhibitor for cholesterol synthesis, is the secondary metabolite of monascus species. the formation of the secondary metabolites of the monascus species is affected by cultivation environment and method. this research uses sweet potato (ipomoea batatas), potato (solanum tuberosum), casava (manihot esculenta), and dioscorea (dioscorea batatas) as the substrates and discusses the best substrate to produce monacolin k. the results show that monascus purpureus ntu 301, with dioscorea ...	2006	16568313
identification of endogenous gibberellins in dormant bulbils of chinese yam, dioscorea opposita.	it is known that dormancy of the genus dioscorea is induced by application of gibberellin (ga) a(3). to understand the role of gas in dormancy induction, endogenous gas have been identified by kovats retention indices and full mass spectra from capillary gas chromatography-mass spectrometry analysis of purified extract from dormant bulbils of dioscorea opposita thunb. these include ga(4), ga(9), ga(12), ga(19), ga(20), ga(24), ga(36), and ga(53); their presence suggests the occurrence of two bio ...	1992	16653203
effect of ethanol extract of dried chinese yam (dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.	in this study, a 40% ethanol extract of chinese yam flour (dioscoreae rhizoma), containing 177 +/- 58 microg/ml of dioscin, was tested in order to evaluate its pharmacological effects on the gastrointestinal tracts of sprague-dawley rats. via the ingestion of the chinese yam extract, the secretion of gastric acid was suppressed in the rats, and gastrointestinal motility increased by as much as 10%. the fecal quantity of rats fed on the chinese yam extract also increased, by more than 40% as comp ...	2006	16756078
dioscorea opposita reverses dexamethasone induced insulin resistance.	the effects of dioscorea opposita (huai shan yao, hsy) on dexamethasone-induced insulin resistance were investigated in vitro and in vivo. d. opposita extract reduced significantly the blood insulin and glucose levels in dexamethasone-induced diabetic rats. in vitro, hsy significantly enhanced insulin-stimulated glucose uptake in 3t3-l1 adipocytes. moreover, hsy increase the mrna expression of glut4 glucose transporter in 3t3-l1 adipocytes. these data suggest that d. opposita has insulin sensiti ...	2007	17084991
diosgenin, a steroidal sapogenin, enhances antigen-specific igg2a and interferon-gamma expression in ovalbumin-sensitized balb/c mice.	the effect of diosgenin, the most abundant sapogenin in chinese yam, on humoral immunity was investigated. ovalbumin (ova)-sensitized and challenged balb/c mice were administered daily with diosgenin for 34 days. the production of ova-specific serum igg2a was significantly enhanced by diosgenin treatment, whereas total ige and ova-specific igg1, igg2a and igm were unaffected. in parallel with the enhancement of igg2a, ova-induced ifn-gamma secretion and mrna expression were markedly elevated in ...	2007	17566144
[quality comparison between two cultivated chinese yam-kunming yam and tiegun yam].	to compare the quality of cultivated chinese yam (dioscorea polystachya turcz.) from yunnan (kunming yam) and henan (tiegum yam) by determining the content of dry substance in fresh sample and the contents of water extracts, ethanol extracts, starch, protein, crude-fat and polysaccharide in dry sample.	2007	17727052
[study on extraction of the total saponins of chinese yam].	a method for the determination of total saponins of chinese yam was established. the dioscin was used as a standard compound, the vanillin-perchloric acid as chromogenic agent and glacial acetic acid as solvent. the extraction technique of asponins from chinese yam was studied by spectrometric method. extracting temperature, extracting time, ethanol concentration and the ratio of raw material and water were selected as four factors to design the orthogonal test, and the optical condition of extr ...	2007	17944200
immunopotentiating effects of four chinese herbal polysaccharides administered at vaccination in chickens.	this study was conducted to evaluate the effects of 4 chinese herbal polysaccharides on the production of serum antibodies and the proliferation of peripheral t lymphocytes, including subpopulations in vaccinated chickens. a total of 450 chickens were randomly assigned to 9 groups at 14 d of age and vaccinated first with live newcastle disease (nd)-infectious bronchitis virus vaccine, and second with nd-infectious bronchitis oil adjuvant vaccine at 28 d of age. at the same time as the first vacc ...	2007	18029798
induction of growth hormone release by dioscin from dioscorea batatas decne.	in this study, dioscin was isolated from dioscoreae rhizoma (dr), which is the rhizome of dioscorea batatas d(ecne). that inhabits broad areas of korea and japan. to determine whether dioscin induced growth hormone (gh) release, we evaluated its induction effects on gh release both in vitro and in vivo. the 70% methanol extract of dr, and its n-hexane and n-buoh fractions, induced rat gh (rgh) release in rat pituitary cells 10-fold, 8-fold, and 5- fold higher than the control (0.36 +/- 0.02 nm), ...	2007	18047799
phytoglycoprotein inhibits interleukin-1beta and interleukin-6 via p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated raw 264.7 cells.	this study was carried out to investigate the anti-inflammatory effects of 30-kda glycoprotein isolated from dioscorea batatas decne (dbd glycoprotein), which consists of carbohydrate content (61%) and protein content (39%) on lipopolysaccharide (lps, 2 microg/ml)-stimulated raw 264.7 cells. we found that dbd glycoprotein (200 microg/ml) has an inhibitory effect on the production of intracellular hydrogen peroxide (h(2)o(2)), on the phosphorylation of p38 mitogen-activated protein (map) kinase, ...	2008	18204996
blocking of intracellular ros production by phytoglycoprotein (30 kda) causes anti-proliferation in bisphenol a-stimulated chang liver cells.	dioscorea batatas decne (dbd) is traditionally used to heal inflammatory disease as a folk medicine. it was reported that a glycoprotein (dbd glycoprotein) with a molecular weight of 30 kda was isolated from dbd and consists of carbohydrate (83.75%) and protein (16.25%) moieties. the previous results showed that it has a strong scavenging activity against hydroxyl radicals without any pro-oxidant activity in the cell-free system. the purpose of the present study was to show whether or not the db ...	2008	18246544
effect of pilopool on forced swimming test in mice.	pilopool is composed of high molecular weight water-soluble chitosan, allium sativum l. extract, mushroom extract, dioscorea batatas d., and purple bamboo salt. this study investigated the effect of pilopool on performance of forced swimming test (fst). first, the immobility time was decreased in pilopool-fed group in comparison with control group on fst. in blood serum, the contents of creatine kinase and lactic dehydrogenase were decreased and the contents of glucose and total protein were inc ...	2008	18300010
identification of dioscorea batatas (sanyak) allergen as an inhalant and oral allergen.	dioscorea batatas is widely used in asia as a herbal medicine or food product with potential health benefits. there have been several reports of occupational asthma caused by inhalation of d. batatas dust. however, there has been no report of systemic allergic reactions after oral administration of d. batatas. two patients with d. batatas allergy were enrolled. one had experienced severe urticaria and angioedema after indigestion, and the other had been exposed to d. batatas dust and was diagnos ...	2008	18303202
the interplay between yam (dioscorea sp.) starch botanical source, micromeritics and functionality in paracetamol granules for reconstitution.	a comparative investigation of the interplay between starch botanical source, micromeritics and their functionality in formulated paediatric paracetamol granules for reconstitution was conducted using starches extracted from five local yam (dioscorea spp.) species. significant differences were observed in the physicochemical properties of the different starches studied (p<0.05). the observed differences in paracetamol dissolution correlated well with the physicochemical properties of the starche ...	2008	18423995
inhibitory effect of 30-kda phytoglycoprotein on expression of tnf-alpha and cox-2 via activation of pkcalpha and erk 1/2 in lps-stimulated raw 264.7 cells.	a 30-kda dbd glycoprotein, which consists of carbohydrate content (61%) and protein content (39%), is a naturally occurring phytoglycoprotein found in dioscorea batatas decne (dbd). in the present study, we investigated the anti-inflammatory potentials of the dbd glycoprotein on lipopolysaccharide (lps, 2 microg/ml)-induced pro-inflammatory signal transduction cascade in murine macrophage cell line (raw 264.7 cells). our results showed that the dbd glycoprotein significantly inhibits the translo ...	2008	18566751
immunomodulatory effects of phytocompounds characterized by in vivo transgenic human gm-csf promoter activity in skin tissues.	to investigate the immunomodulatory activities of phytocompounds for potential therapeutics, we devised an in vivo, transgenic, human cytokine gene promoter assay using defined epidermal skin cells as test tissue. test compounds were topically applied to mouse skin before or after gene gun transfection, using a cytokine gene promoter-driven luciferase reporter. croton oil, an inflammation inducer, induced transgenic gm-csf and tnf-alpha promoter activities in skin epidermis 6-fold and 3.4-fold, ...	2008	18622761
pharmacological interventions for clozapine-induced hypersalivation.	clozapine is widely used for people with schizophrenia. although agranulocytosis, weight gain, and cardiac problems are serious problems associated with its use, hypersalivation, sometimes of a gross and socially unacceptable quantity, is also common (30-80%).	2008	18646130
plant glycoprotein modulates the expression of interleukin-1beta via inhibition of map kinase in hmc-1 cells.	dioscorea batatas decne (dbd) is used to heal various disorders of the kidney and lungs as an herbal agent in korea. the purpose of the present study was to determine whether the dbd glycoprotein regulates the inflammatory reaction stimulated by phorbol-12-myristate 13-acetate plus calcium ionophore a23187 (pmaci) in human mast cells (hmc-1). the results indicate that dbd glycoprotein decreased gene expression of interleukin (il)-1beta and cyclooxygenase (cox)-2 in pmaci-stimulated hmc-1 cells t ...	2008	18685203
relationship between the physicochemical properties of starches and the glycemic indices of some jamaican yams (dioscorea spp.).	starch granules from round leaf yellow yam (ry), lucea yam (ly), white yam (wy), and chinese yam (cy) grown in jamaica were isolated and the relationship between starch amylose content, crystallinity, microscopic properties, in vitro digestibility, and the glycemic index (gi) of the tubers was investigated. the results indicate that ry had the highest amylose content (265.30 +/- 0.09 g/kg starch) while cy the lowest (111.44 +/- 0.03 g/kg starch). a corresponding variation in starch digestibility ...	2008	18727011
polysaccharides from dioscorea batatas induce tumor necrosis factor-alpha secretion via toll-like receptor 4-mediated protein kinase signaling pathways.	the bioactive polysaccharides (named zpf1) from yam ( dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on c2-oh and c3-oh, around 28%. the zpf1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (tnfalpha). toll-like receptor 4 is proved to be one of the cellular receptors in zpf1-mediated tnfalpha secretion. reactive oxygen species transmission and pi3-kinase ar ...	2008	18841980
mannose-binding lectin from yam (dioscorea batatas) tubers with insecticidal properties against helicoverpa armigera (lepidoptera: noctuidae).	the amino acid sequence of mannose-binding lectin, named db1, from the yam (dioscorea batatas, synonym dioscorea polystachya) tubers was determined. the lectin was composed of two isoforms db1(cys86) and db1(leu86) consisting of 108 amino acid residues with 90% sequence homology between them. db1 showed a high sequence similarity to snowdrop (galanthus nivalis) bulb lectin, gna; especially, the carbohydrate-binding sites of gna were highly conserved in db1. db1 interacted with d-mannose residues ...	2009	19271711
[clinical observation on ziyin tongbi decoction in treating benign prostatic hyperplasia].	to evaluate the efficacy and safety of ziyin tongbi decoction (ztd) in treating benign prostatic hyperplasia (bph).	2008	19317162
antioxidative ability, dioscorin stability, and the quality of yam chips from various yam species as affected by processing method.	the antioxidative ability, stability of storage protein dioscorin, and the quality of fried yam chips from different cultivars of chinese yams influenced by various processing treatments were investigated. total phenolic content and dpph free radical scavenging effect were found to be the highest in mingchien (mc) and the lowest in keelung (kl) yam. following processing, freeze-dried yams of all varieties showed the least decrease in total phenolic compounds and dpph radical scavenging effect, w ...	2009	19323725
diosgenin attenuates allergen-induced intestinal inflammation and ige production in a murine model of food allergy.	diosgenin, the major sapogenin contained in the chinese yam, has recently been shown to promote systemic t helper 1-type immunity in a murine model of airway hypersensitivity. in this study, we hypothesized that diosgenin might be effective in modulating food allergy. balb/c mice were either left untreated (naïve; na) or administered daily with vehicle (vh; olive oil) and/or diosgenin (100 or 200 mg/kg) by gavage throughout the experiment. except for the na group, the mice were sensitized with o ...	2009	19343624
glycoprotein isolated from dioscorea batatas decne modulates expressions of il-4 and il-10 in primary-cultured mouse lymphocytes.	in the present study, we investigated the anti-allergic activity of a glycoprotein isolated from dioscorea batatas decne (dbd glycoprotein, 30 kda) on ovalbumin (ova, 100 microg ml(-1))-induced t helper (th) type-2 response in primary cultured mouse lymphocytes. our results revealed that the dbd glycoprotein (200 microg ml(-1)) significantly attenuated the expressions of interleukin (il)-4 and il-10, whereas enhanced the expression of interferon (ifn)-gamma in ova (100 microg ml(-1))-treated pri ...	2009	19548268
carboxymethyl chinese yam starch: synthesis, characterization, and influence of reaction parameters.	carboxymethyl starch (cms) was obtained as a product of the reaction of starch and monochloroacetic acid (mca) in the presence of sodium hydroxide. the influence of the molar ratio of naoh/agu, the molar ratio of mca/agu, the reaction time, reaction temperature, and the water content on the degree of substitution (ds) was studied. the optimal molar ratio of naoh/agu and mca/agu is 2.4 and 1.0, respectively. increase of the ratio of naoh/agu or mca/agu leads to an increase in ds, but only to cert ...	2009	19665107
the screening method of a bifidogenic dietary fiber extracted from inedible parts of vegetables.	total dietary fiber (df) was extracted from the inedible parts of vegetables such as peel of taro and chinese yam, pea pod, broad bean pod, and broad bean testa. effects of these fibers on the growth of bifidobacteria were determined by two kinds of experiments: one was to determine the increase of bifidobacterium longum jcm1217 (b. longum) in medium containing df, the other was an in vitro fermentation of the df by anaerobic slurries of mixed human fecal or rat cecal microbiota. anaerobic cultu ...	2009	19763042
evaluation of the phototoxic potential of plants used in oriental medicine.	phototoxicity can be either harmful or beneficial. yet the phototoxicity of oriental medicinal plants is an understudied area. the purpose of this study is to fill in this gap.	2010	19818392
evaluation of the material and tablet formation properties of modified forms of dioscorea starches.	starches obtained from four different dioscorea species-namely, white yam (dioscorea rotundata), bitter yam (dioscorea dumetorum), chinese yam (dioscorea oppositifolia), and water yam (dioscorea alata)-were modified by cross-linking, hydroxypropylation, and dual modification-cross-linking followed by hydroxypropylation. the physicochemical, material, and tablet properties of the modified starches were investigated with the aim of understanding their properties to determine their potential use fo ...	2009	19832640
fermentation characterization of chinese yam polysaccharide and its effects on the gut microbiota of rats.	rat was used to characterize chinese yam polysaccharides (cyps). in exp. 1, maximum volume and rate of gas production in cyp 3-supplemented group were higher than other cyp-supplemented groups and control group, while ph values and nh3 contents in cyp 2-, cyp 3-, and cyp 4-supplemented groups were lower than control group. contents of acetate, propionate and butyrate increased by supplementing cyp 3 or cyp 4 compared to other groups, except for glucose-supplemented group. contents of isobutyrate ...	2009	19936111
silage preparation and nutritive value of chinese yam by-product.	the objective of this experiment was to determine the ensiling characteristics, nutrient composition and nutritive value of chinese yam by-product (cybp) silage treated without additive (control), with lactic acid bacteria (ly), with dried beet pulp (by), or with mixtures of lactic acid bacteria and dried beet pulp (lby) for a fermentation period of 150 days. the nutritive value of cybp silage was studied in an in vivo digestibility trial using wethers in a 4 x 4 latin square design. addition of ...	2009	20163599
phylogenetic analyses of an isolate obtained from potato in 1985 revealed potato virus x was introduced to china via multiple events.	potato virus x (pvx) is one of the most common plant viruses that cause great economic losses to solanaceous plants. we have previously reported the complete genomic sequence of the 2006 chinese potato isolate fx21 and demonstrated that pvx isolates cluster into two groups: eurasia and america. here, we present the complete genomic sequence of one pvx isolate collected from potato in 1985 (pvx-1985). the genome of pvx-1985 is identical to that of fx21 in length and has the same genomic structure ...	2010	20221681
anti-inflammatory activity of bark of dioscorea batatas decne through the inhibition of inos and cox-2 expressions in raw264.7 cells via nf-κb and erk1/2 inactivation.	we identified a bioactive herbal medicine with anti-inflammatory activity from an ethanol extract derived from the bark of dioscorea batatas decne (bdb) in raw264.7 cells. we examined the effects of bdb on nitric oxide (no) and prostaglandin e(2) (pge(2)) production in lps-induced raw264.7 cells. bdb consistently inhibited both no and pge(2) production in a dose-dependent manner, with an ic(50) of 87-71 μg/ml, respectively. the reduction of no and pge(2) production were accompanied by a reductio ...	2010	20691245
understanding the germination of bulbils from an ecological perspective: a case study on chinese yam (dioscorea polystachya).	bulbils serve as a means of vegetative reproduction and of dispersal for many plants; this latter aspect making them analogous to seeds. however, germination of bulbils may differ considerably from seeds due to dissimilar anatomical structures and perhaps environmental cue perception. the few laboratory studies done on bulbils suggest that their germination is similar to that of seeds in the same habitats and to vegetative buds of winter-dormant plants. the present study is the first to examine ...	2010	20880931
effects of a multi-herbal extract on type 2 diabetes.		2011	21375727
characterization and immunopotentiating effects of the glycoprotein isolated from dioscorea batatas.	we demonstrate that glycoprotein isolated from dioscorea batatas (gdb) has immunostimulatory effects including macrophage activation. analysis of infiltration of inflammatory cells into peritoneal cavity showed gdb treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. treatment of spleen cells isolated from c57bl/6 mice with gdb significantly increased the proliferation of b cells and t cells induced by lps and cona, ...	2011	21660150
apolipoprotein a5-12238 t>c gene polymorphism and risk factors for metabolic syndrome in the guo shan yao and the han populations.		2011	21707471
batatasin i, a naturally occurring phenanthrene derivative, isolated from tuberous roots of dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast cells.	to find anti-inflammatory compounds from the tuberous roots of dioscorea batatas, we isolated 6-hydroxy-2,4,7-trimethoxyphenanthrene (batatasin i) from the dichloromethane (ch(2)cl(2)) fraction of this plant. batatasin i inhibited both the generation of prostaglandin d(2) (pgd(2)), leukotriene c(4) (ltc(4)) and degranulation reaction in mouse bone marrow-derived mast cells (bmmcs). this compound inhibited cyclooxygenase-2 (cox-2) dependent pgd(2) generation in a dose dependent manner, with ic(50 ...	2011	21720007
protective activity of 30kda phytoglycoprotein from glucose/glucose oxidase-induced cell death in primary cultured mouse thymocytes.	dioscorea batatas decne (dbd) has been traditionally used as herbal agent in folk medicine. dbd glycoprotein with a molecular weight of 30kda consists of carbohydrate (83.75%) and protein (16.25%), and has a strong anti-oxidative activity. to understand the protection from thymocytes death, we evaluated the activity changes of pro-apoptotic factors [cytochrome c, caspase 3, poly(adp-ribose) polymerase (parp), ap-1, nf-+¦b and nitric oxide (no)] by dbd glycoprotein from glucose/glucose oxidase (g ...	2008	21783844
anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (dioscorea batatas) through inhibition of prostaglandin d₂ and leukotriene c₄ production in mouse bone marrow-derived mast cells.	6-hydroxy-2,7-dimethoxy-1,4-phenanthraquinone (paq) isolated from the tuberous roots of yam (dioscorea batatas) inhibited cyclooxygenase-2 (cox-2) and cyclooxygenase-1 (cox-1) dependent prostaglandin d(2) (pgd(2)) generation in mouse bone marrow-derived mast cells in a concentration-dependent manner with ic(50) values of 0.08 μm and 0.27 μm, respectively. in the western blotting with specific anti-cox-2 antibodies, the decrease of the quantity of pgd(2) was accompanied by a decrease in the cox-2 ...	2011	21975811
raw chinese yam (dioscorea opposita) promotes cecal fermentation and reduces plasma non-hdl cholesterol concentration in rats.	we examined the effects of raw chinese yam (dioscorea opposita), containing resistant starch (rs), on lipid metabolism and cecal fermentation in rats. raw yam (ry) and boiled yam (by) contained 33.9% and 6.9% rs, respectively. male sprague-dawley rats were fed a cholesterol-free, control (c) diet supplemented with or without 15 and 30 g of ry or by/100 g for 3 wk. plasma total cholesterol concentrations in the tail vein of rats fed the 30% ry diet were significantly lower than in the c group thr ...	2011	22293211
extract from dioscorea batatas ameliorates insulin resistance in mice fed a high-fat diet.	the aim of this study was to investigate whether dioscorea batatas (db) extract attenuates high-fat diet (hfd)-induced insulin resistance in the visceral adipose tissues of mice, and by what mechanism(s). mice were fed a hfd for 4 weeks to induce the early development of insulin resistance. the db extract was administered to mice fed a hfd by oral gavage at a dose of 100 mg/kg body weight daily for 7 weeks. biochemical parameters in blood were measured using enzymatic kits, and the expression le ...	2012	22424459
suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of chinese yam in vascular smooth muscle cells through inhibition of mapk, akt and nf-κb.	atherosclerosis is a chronic inflammatory disease associated with increased expression of adhesion molecules in vascular smooth muscle cells (vsmcs). the objective of this study was to examine the in vitro effects of extract from aerial bulbil of dioscorea batatas decne (db-ex) on the ability to suppress the expression of adhesion molecules induced by tnf-α. we also identified bioactive components from a methanol extract. vsmcs pre-exposed to db-ex (10-100 μg/ml) were stimulated with tnf-α (10 n ...	2012	22583650
the effects of chinese yam-epimedium mixture on respiratory function and quality of life in patients with chronic obstructive pulmonary disease.	to examine the clinical effects of a mixture of chinese yam and epimedium in patients with stable moderate or severe chronic obstructive pulmonary disease (copd).	2012	22876444
complete nucleotide sequence and construction of an infectious clone of chinese yam necrotic mosaic virus suggest that macluraviruses have the smallest genome among members of the family potyviridae.	the complete nucleotide sequence of chinese yam necrotic mosaic virus (cynmv) was determined from cloned virus cdna. the cynmv genomic rna is 8224 nucleotides in length, excluding the poly(a) tail, and contains one long open reading frame encoding a large polyprotein of 2620 amino acids. cynmv has no counterpart to the p1 cistron and a short hc-pro cistron located at the 5' side of the potyvirus genome. a full-length cdna clone, pcynmv, was assembled under the control of the cauliflower mosaic v ...	2012	22886278
[optimization of processing technology for pieces of sulfur-free chinese yam].	to optimize the best gradient drying technology of pieces of sulfur-free chinese yam, and provide technique parameter for processing of pieces of sulfur-free chinese yam.	2012	23236818
synergistic induction of inos by ifn-γ and glycoprotein isolated from dioscorea batatas.	dioscorea species continue to be used in traditional chinese medicine, and represent a major source of steroid precursors for conventional medicine. in the previous study, we isolated glycoprotein (gdb) from dioscorea batatas, characterized, and demonstrated immunostimulating activity in c57bl/6 mice. the aim of this study was to investigate the mechanism whereby gdb activates macrophages. macrophages activation by gdb was investigated by analyzing the effects of gdb on nitric oxide (no) product ...	2012	23269906
dioscorin pre-treatment protects a549 human airway epithelial cells from hydrogen peroxide-induced oxidative stress.	hydrogen peroxide (h(2)o(2)) is a highly reactive oxygen species involved in lung and bronchial epithelium injury. increased h(2)o(2) levels have been reported in expired breath condensates of patients with inflammatory airway diseases such as chronic obstructive pulmonary disease. protecting airway epithelial cells from oxidative stress is an important task in the prevention and management of airway diseases. previous studies demonstrate that yam (dioscorea batatas decne) has antioxidant and an ...	2013	23575601
anther culture of wheat (triticum aestivum l.) f1's and their reciprocal crosses.	anthers from three sets of wheat (triticum aestivum l. em. thell) f1's and their reciprocal crosses, made between parental lines differing greatly in their ability to produce microspore derived callus, were cultured on the chinese potato medium so that we could 1) more clearly define the role of nuclear or cytoplasmic factors within t. aestivum in transferring the ability to undergo in vitro androgenesis, and 2) to briefly review the gametic representation and disease screening potential of the ...	1982	24270565
macrophage activation by glycoprotein isolated from dioscorea batatas.	we demonstrate that glycoprotein isolated from dioscorea batatas (gdb) activates macrophage function. analysis of the infiltration of macrophages into peritoneal cavity showed gdb treatment significantly increased the recruitment of macrophages into the peritoneal cavity. in order to further confirm and investigate the mechanism of gdb on macrophage activation, we analyzed the effects of gdb on the cytokine expression including il-1β, tnf-α, and il-6 in mouse peritoneal macrophages. gdb increase ...	2011	24278568
inhibition of photosynthesis and respiration by batatasins.	effects of batatasins i, iii and v, phenolic growth inhibitors occuring in dormant bulbils of dioscorea batatas decne., on photosynthetic reactions of chloroplasts from spinach (spinacia oleracea l.) and on respiration of mitochondria from potatoes (solanum tuberosum l.) were investigated. in chloroplasts, the batatasins effectively inhibited co2-dependent oxygen evolution and electron flow from water to acceptors such as dichlorophenolindophenol, ferricyanide and methylviologen. photosystem-i d ...	1978	24414012
aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2k1c hypertensive rats.	dioscorea opposita thunb. (huai shan yao, dot), a common staple food in china, has been used for more than 2000 years in traditional chinese medicine (tcm) to treat different systemic diseases including hypertension. the objective of this study was to investigate the possible antihypertensive effects of the aqueous extract of (dot) in renovascular hypertensive rats as well as the mechanism in reducing blood pressure.	2014	24447776
effect of polarity and kinetin on the browning reaction of dioscorea batatas and d. japonica.		1969	24515433
isolation of (+)-abscisin ii from dormant aerial tubers of dioscorea batatas.	the occurrence of at least three growth inhibitors was demonstrated in the dormant aerial tubers of dioscorea. one of the inhibitors was isolated in crystalline form and identified as (+)-abscisin ii by the infrared and ultraviolet spectra as well as by the optical rotatory dispersion.	1967	24522653
interaction of some commercial teas with some carbohydrate metabolizing enzymes linked with type-2 diabetes: a dietary intervention in the prevention of type-2 diabetes.	this study is aimed at assessing the inhibitory effect of teas on key enzymes (α-amylase and α-glucosidase) linked with type-2 diabetes and their antioxidant properties. four samples of three brands were used; infusions of green tea (gt), 2 brands of black tea (bt), and a formulated herbal preparation for diabetes (adt) (white tea, radix puerariae, radix ophiopogonis, hawthorn berry, chinese yam, and fragrant solomon seal rhizome) were prepared and subsequently analyzed for their total phenol, a ...	2014	24527218
antioxidant chinese yam polysaccharides and its pro-proliferative effect on endometrial epithelial cells.	chinese yam polysaccharide (cyp) was successfully isolated from the rhizoma of dioscorea opposita and its chemical characteristics were determined. antioxidant and pro-proliferative activity of cyp on human endometrial epithelial cells in vitro were investigated. role of cyp on cell proliferation was also evaluated by examining pro-apoptotic and anti-apoptotic proteins bax and bcl-2 by western blot analysis. chemical composition analysis indicated that cyp was mainly composed of mannose, glucose ...	2014	24530337
chinese yam extracts containing β-sitosterol and ethyl linoleate protect against atherosclerosis in apolipoprotein e-deficient mice and inhibit muscular expression of vcam-1 in vitro.	atherosclerosis is a chronic inflammatory disease, which is associated with increased expression of adhesion molecules and monocyte recruitment into the arterial wall. this study evaluated whether hexane extracts from the edible part (db-h1) or bark region (db-h2) of dioscorea. batatas decne have anti-atherosclerotic properties in vivo and in vitro experiments. we also identified bioactive components in the hexane extracts. thirty-six apolipoprotein e (apoe(-/-) ) mice and 12 control (c57bl/6j) ...	2014	24689699
traditional chinese medicine herbal extracts of cibotium barometz, gentiana scabra, dioscorea batatas, cassia tora, and taxillus chinensis inhibit sars-cov replication.	development of anti-severe acute respiratory syndrome associated coronavirus (sars-cov) agents is pivotal to prevent the reemergence of the life-threatening disease, sars. in this study, more than 200 extracts from chinese medicinal herbs were evaluated for anti-sars-cov activities using a cell-based assay that measured sars-cov-induced cytopathogenic effect (cpe) in vitro on vero e6 cells. six herbal extracts, one each from gentianae radix ( lóng dǎn; the dried rhizome of gentiana scabra), dios ...	2011	24716104
polysaccharides from dioscorea ( shān yào) and other phytochemicals enhance antitumor effects induced by dna vaccine against melanoma.	adjuvants can be used to enhance the immunogenicity of antigens and improve the efficacy of vaccines. potent adjuvant action is known to often correlate with the activation of the transcription factor, nuclear factor-κb (nf-κb). specific plant polysaccharides and a variety of phytochemicals from foods and traditional medicinal herbs have been shown to modulate nf-κb activation. in the present study, selected plant polysaccharides and phytochemicals were evaluated for use as a dna vaccine adjuvan ...	2014	24872932
using "dioscorea batatas bean"-like silver nanoparticles based localized surface plasmon resonance to enhance the fluorescent signal of zinc oxide quantum dots in a dna sensor.	we reported here the preparation of "dioscorea batatas bean"-like silver nanoparticles (agnps) and the unique structure provided the agnps good localized surface plasmon resonance (lspr) property. in addition, zinc oxide quantum dots (zno qds) were also synthesized and found with good fluorescent property. furthermore, the zno qds decorated exfoliated graphene oxide (ego-zno) was prepared via electrostatic interaction. the named nanomaterials were applied in a lspr-induced fluorescent dna sensor ...	2014	24912034
a protocol for in vitro production of microtubers in chinese yam (dioscorea opposita).	chinese yam (dioscorea opposita) is an important tuberous crop owing to its dual use as a food as well as a medicine. tissue culture techniques allow the rapid multiplication of virus-free plant materials. the use of microtubers offers an attractive alternative to in vitro-grown plantlets for the micropropagation and exchange of healthy chinese yam materials. a protocol for the in vitro production of chinese yam microtubers was developed in this study. though we tested both one-step and two-step ...	2014	25036126
antioxidant and anti-inflammatory effects of yam (dioscorea batatas decne.) on azoxymethane-induced colonic aberrant crypt foci in f344 rats.	yam (dioscorea batatas decne.) has long been used as a health food and oriental folk medicine because of its nutritional fortification, tonic, anti-diarrheal, anti-inflammatory, antitussive, and expectorant effects. reactive oxygen species (ros), which are known to be implicated in a range of diseases, may be important progenitors of carcinogenesis. the aim of this study was to investigate the modulatory effect of yam on antioxidant status and inflammatory conditions during azoxymethane (aom)-in ...	2014	25054106
bioactive proteins and peptides isolated from chinese medicines with pharmaceutical potential.	some protein pharmaceuticals from chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. bioactive proteins with various pharmacological properties have been successfully isolated from animals such as hirudo medicinalis (medicinal leech), eisenia fetida (earthworm), and mesobuthus martensii (chinese scorpion), and from herbal medicines derived from species such as cordyceps militaris, ganoderma, momordica cochinchinensis, viscum album, poria cocos, s ...	2014	25067942
new and unusual forms of calcium oxalate raphide crystals in the plant kingdom.	calcium oxalate crystals in higher plants occur in five major forms namely raphides, styloids, prisms, druses and crystal sand. the form, shape and occurrence of calcium oxalate crystals in plants are species- and tissue-specific, hence the presence or absence of a particular type of crystal can be used as a taxonomic character. so far, four different types of needle-like raphide crystals have been reported in plants. the present work describes two new and unusual forms of raphide crystals from ...	2014	25139563
yam (dioscorea batatas) root and bark extracts stimulate osteoblast mineralization by increasing ca and p accumulation and alkaline phosphatase activity.	yam (dioscorea batatas) is widely consumed as functional food for health promotion mainly in east asia countries. we assessed whether yam root (tuber) or bark (peel) extracts stimulated the activity of osteoblasts for osteogenesis. mc3t3-e1 cells (mouse osteoblasts) were treated with yam root extracts (water or methanol) (study i) or bark extracts (water or hexane) (study ii) within 0~10 μg/ml during the periods of osteoblast proliferation (5~10 day), matrix maturation (11~15 day) and mineraliza ...	2014	25320717
changes in main nutrients and medicinal composition of chinese yam (dioscorea opposita) tubers during storage.	the changes in the main nutrient and medicinal components during the storage of the chinese yam (dioscorea opposita) tubers were studied. the harvested tubers were stored under ambient conditions (10 °c to 18 °c, 60 % to 80 % relative humidity) and cold temperature and packaged conditions (4 °c, 60 % to 65 % relative humidity) for 45 day. the allantoin, starch, total alcohol-soluble sugar, reducing sugar, protein, and moisture contents of the samples were evaluated. their amylase activities were ...	2014	25328193
preparation of oligosaccharides from chinese yam and their antioxidant activity.	in the present study, the oligosaccharides from chinese yam were prepared by hydrolysis with hydrogen peroxide (h2o2), which can cleave the glycosidic bonds in polysaccharides. the hydrolysis conditions were optimised by using a central composite design (ccd) as follows: reaction time 4.02 h, temperature 84.35 °c, and h2o2 concentration 2.46%, under which the yield of chinese yam derived oligosaccharides (cyos) reached 11.73%, which was consistent with the predicted yield by analysis of the resu ...	2015	25466131
purification and structural characterization of chinese yam polysaccharide and its activities.	purification and structural characterization of chinese yam polysaccharide were investigated and its activities were analyzed. results indicated that a single component polysaccharide with a molecular weight of 16,619 da was obtained after hot water extraction with sequential sevage deproteinization, hsccc and sephadex g-100 size-exclusion chromatography. the ftir analysis showed that it had characteristic absorptive peaks and contained uronic acid. the methylation and gc-ms analysis showed that ...	2015	25498730
dioscorea batatas extract attenuates high-fat diet-induced obesity in mice by decreasing expression of inflammatory cytokines.	the objective of the present study was to determine whether dioscorea batatas (db) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (hfd) and whether genes associated with adipogenesis and inflammation could be modulated by a diet containing db extract.	2015	25681821
glycaemic index and glycaemic load of selected popular foods consumed in southeast asia.	the objective of the present study was to determine the glycaemic index (gi) and glycaemic load (gl) values of standard portion sizes of southeast asian traditional foods. a total of fifteen popular southeast asian foods were evaluated. of these foods, three were soft drinks, while the other twelve were solid foods commonly consumed in this region. in total, forty-seven healthy participants (eighteen males and twenty-nine females) volunteered to consume either glucose at least twice or one of th ...	2015	25716365
prevention of enzymatic browning of chinese yam (dioscorea spp.) using electrolyzed oxidizing water.	in this study, the effects of electrolyzed oxidizing water (eow) on the prevention of enzymatic browning of fresh-cut "jiu jinhuang" chinese yam were investigated. the yams were immersed in the inhibitors for 25 min at 20 °c. compared with the tap water (tw) treatment, the chromatic attributes were significantly different after 72 h of storage (p < 0.05). the activities of polyphenol oxidase (ppo, ec 1.10.3.1), peroxidase (pod, ec 1.11.1.7), and l -phenylalanine ammonia lyase (pal, ec 4.3.1.5) w ...	2015	25736015
a comparison of near- and mid-infrared spectroscopic methods for the analysis of several nutritionally important chemical substances in the chinese yam (dioscorea opposita): total sugar, polysaccharides, and flavonoids.	the chinese yam (dioscorea opposita) is a basic food in asia and especially china. consequently, an uncomplicated, reliable method should be available for the analysis of the quality and origin of the yams. thus, near-infrared (nir) and mid-infrared (mid-ir) spectroscopic methods were developed to discriminate among chinese yam samples collected from four geographical regions. the yam samples were analyzed also for total sugar, polysaccharides, and flavonoids. these three analytes were used to c ...	2015	25742643
complete nucleotide sequence of artichoke latent virus shows it to be a member of the genus macluravirus in the family potyviridae.	complete genomic sequences of artichoke latent virus (arlv) have been obtained by classical or high-throughput sequencing for an arlv isolate from italy (itbr05) and for two isolates from france (fr37 and fr50). the genome is 8,278 to 8,291 nucleotides long and has a genomic organization comparable with that of chinese yam necrotic mosaic virus (cynmv), the only macluravirus fully sequenced to date. the cleavage sites of the viral polyprotein have been tentatively identified by comparison with c ...	2015	25760520
ultrastructure of underutilized tuber starches and its relation to physicochemical properties.	starches from five underutilized tubers (canna, potato, chinese yam, water chestnut, and taro) were extracted to investigate quantitative structure-property relationships (qspr) in each starch using a combination of x-ray diffraction (xrd) and small-angle x-ray scattering (saxs). structural parameters of the tuber starches were determined using the paracrystalline model. swelling power (sp), water solubility index (wsi), amylose leaching (aml), and thermal properties were also measured. the xrd ...	2015	26041241
conformation and location of amorphous and semi-crystalline regions in c-type starch granules revealed by sem, nmr and xrd.	the conformations and locations of amorphous and semi-crystalline regions in c-type starch granules from chinese yam were evaluated by a combination of morphology and spectroscopy studies during acid hydrolysis. scanning electron micrographs showed that amorphous or less crystalline areas were essentially located in the centre part of c-type starch granules, whereas the semi-crystalline and amorphous growth rings were found mainly in the outer part of the granules. (13)c cross-polarization magic ...	2008	26050163
a new fluorescent nitrogen-doped carbon dot system modified by the fluorophore-labeled ssdna for the analysis of 6-mercaptopurine and hg (ii).	a simple, environmentally friendly hydrothermal method was used to prepare strongly luminescent, nitrogen-doped carbon dots (ncds) with the use of chinese yams as a source of carbon and nitrogen. such ncds have an average size of 2.7±1.4 nm; they emit blue light at 420 nm and have a quantum yield of up to 9.3%. thus, carboxyfluorescein (fam)-dna macro-molecules were assembled on the surfaces of the ncds, and stabilised by strong π-π stacking; the so formed hybrid nano-sensors were found to have ...	2015	26120815
a novel, stable, estradiol-stimulating, osteogenic yam protein with potential for the treatment of menopausal syndrome.	a novel protein, designated as doi, isolated from the chinese yam (dioscorea opposita thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (hrt), which is known to have undesirable side effects. doi is an acid- and thermo-stable protein with a distinctive n-terminal sequence gly-ile-gly-lys-ile-thr-thr-tyr-trp-gly-gln-tyr-ser-asp-glu-pro-ser-leu-thr-glu. doi was found to stimulate estradiol biosynthesis in rat ovarian ...	2015	26160710
prebiotic effect of diosgenin, an immunoactive steroidal sapogenin of the chinese yam.	this study investigated the effect of diosgenin, a yam-derived phytochemical, on the growth of enteric lactic acid bacteria (lab). the in vivo effect of diosgenin on the density of intestinal flora was examined in a murine model of food allergy. oral administration with diosgenin markedly restored the diminished density of faecal lab associated with allergic reactions. the direct effect of diosgenin and several structure-related steroidal compounds on the growth of faecal anaerobes isolated from ...	2012	26434311
antidiabetic effects of yam (dioscorea batatas) and its active constituent, allantoin, in a rat model of streptozotocin-induced diabetes.	the objective of this study was to investigate the therapeutic efficacies of crude yam (dioscorea batatas) powder (py), water extract of yam (ey), and allantoin (the active constituent of yam) in streptozotocin (stz)-induced diabetic rats with respect to glucose, insulin, glucagon-like peptide-1 (glp-1), c-peptide, glycated hemoglobin (hbalc), lipid metabolism, and oxidative stress. for this purpose, 50 rats were divided into five groups: normal control (nc), diabetic control (stz), and stz plus ...	2015	26501316
high-throughput determination of multi-mycotoxins in chinese yam and related products by ultra fast liquid chromatography coupled with tandem mass spectrometry after one-step extraction.	a simple, accurate and sensitive ultra fast liquid chromatography coupled with tandem mass spectrometry (uflc-ms/ms) method was developed for high-throughput determination of aflatoxins (afb1, afb2, afg1 and afg2), ochratoxin a (ota), fumonisins (fb1 and fb2) and zearalenone (zea) in chinese yam, yam flours and yam-derived products. mycotoxins were extracted from the samples with methanol-water-formic acid (79:20:1, v/v/v) and no further cleanup step before analysis. after optimization of some c ...	2016	27085799
antioxidant and antitumor activities of the extracts from chinese yam (dioscorea opposite thunb.) flesh and peel and the effective compounds.	the aims of this study are to investigate the antioxidant and antitumor activities of the water and ethanol extracts isolated from chinese yam (dioscorea opposite thunb.) flesh (cyf) and peel (cyp) and the effective compounds. it was found that all peel portions have a better effect on reactive oxygen (ros) scavenging assay than meat portions, especially for the water extract of chinese yam peel (cyp-w). its ic50 values for hydroxyl radical (oh•) scavenging assay (744.25 ± 3.46 μg/ml) and for 1, ...	2016	27122252