| variability of the essential oil from three sorts of echinacea moench genus during ontogenesis. | variability of the essential oil from three sorts of echinacea moench genus during ontogenesis the content and quality of the essential oil in relation to the main ontogenetic stages of plants were studied in three various sorts of echinacea genus. the comparison included echinacea purpurea, echinacea atrorubens, and echinacea pallida. the differences in the content of the oil in different parts of plants and the abundance of individual oil constituents in oils from the sorts under study at the ... | 2007 | 17867523 |
| echinacea purpurea and p-glycoprotein drug transport in caco-2 cells. | echinacea is widely used as a medical herbal product, but its interaction potential with the drug efflux transporter p-glycoprotein (p-gp) has not yet been evaluated. the interaction potential of echinacea purpurea towards p-gp mediated drug transport was studied in human intestinal caco-2 cells. digoxin (30 nm) was used as a substrate and verapamil as a control inhibitor. ethanol, 0.8%, needed for herbal extraction and compatibility with the commercial products, inhibited the net digoxin flux b ... | 2009 | 18688789 |
| enhancement of innate and adaptive immune functions by multiple echinacea species. | echinacea preparations are commonly used as nonspecific immunomodulatory agents. alcohol extracts from three widely used echinacea species, echinacea angustifolia, echinacea pallida, and echinacea purpurea, were investigated for immunomodulating properties. the three echinacea species demonstrated a broad difference in concentrations of individual lipophilic amides and hydrophilic caffeic acid derivatives. mice were gavaged once a day (for 7 days) with one of the echinacea extracts (130 mg/kg) o ... | 2007 | 17887935 |
| echinacea purpurea and allium sativum as immunostimulants in fish culture using nile tilapia (oreochromis niloticus). | the study was conducted to evaluate the efficiency of echinacea (e) and garlic (g) supplemented diets as immunostimulant for tilapia (oreochromis niloticus). seven treatments were designed including a control (c). fish were fed on 35% protein diet at a rate of 3% body weight per day. echinacea (1.0 ppt) and garlic (3%) were incorporated in the feed, which was administered for periods of 1, 2 and 3 months (summer season), followed by basal diet for 4 more months (winter season). neutrophil adhere ... | 2010 | 20455962 |
| liver enzyme-mediated oxidation of echinacea purpurea alkylamides: production of novel metabolites and changes in immunomodulatory activity. | the medicinal plant echinacea is widely used to treat upper respiratory infections and is reported to stimulate the human immune system. a major constituent class of echinacea, the alkylamides, has immunomodulatory effects. recent studies show that alkylamides are oxidized by cytochrome p450 enzymes, but the immunomodulatory activity of these products is unknown. the objectives of this study were to characterize the products formed by incubation of an echinacea extract and an isolated alkylamide ... | 2006 | 17054047 |
| assessment of the effect of echinacea purpurea (l.) moench on apoptotic and mitotic activity of liver cells during intoxication by cadmium. | cadmium (cd(2+)) is an important industrial pollutant, although its mechanism of toxicity has not been completely clarified. cd(2+) is toxic to a wide range of organs and tissues, however, the primary target organs of cd(2+) toxicity are the liver and kidney. echinacea purpurea stimulating one or another tread of the immune system stimulates the expression of immunoglobulins and interferons. the experiments were performed on white laboratory mice using intraperitoneal (i.p.) injections 0.05 ld(5 ... | 2007 | 17404071 |
| phytotherapeutic effects of echinacea purpurea in gamma-irradiated mice. | echinacea (e.) purpurea herb is commonly known as the purple coneflower, red sunflower and rudbeckia. in this paper, we report the curative efficacy of an echinacea extract in gamma-irradiated mice. e. purpurea was given to male mice that were divided into five groups (control, treated, irradiated, treated before irradiation & treated after irradiation) at a dose of 30 mg/kg body weight for 2 weeks before and after irradiation with 3 gy of gamma-rays. the results reflected the detrimental reduct ... | 2007 | 17993747 |
| clinical assessment of cyp2d6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, st. john's wort, and echinacea. | cytochrome p450 2d6 (cyp2d6), an important cyp isoform with regard to drug-drug interactions, accounts for the metabolism of approximately 30% of all medications. to date, few studies have assessed the effects of botanical supplementation on human cyp2d6 activity in vivo. six botanical extracts were evaluated in three separate studies (two extracts per study), each incorporating 16 healthy volunteers (eight females). subjects were randomized to receive a standardized botanical extract for 14 day ... | 2008 | 18214849 |
| synergetic effects of oral administration of levamisole and echinacea purpurea on immune response in wistar rat. | this research investigated the effects of levamisole and echinacea purpurea (ep), separately and together on the immune response of the rat as a laboratory model. in this experiment, 40 male wistar rats were obtained and divided into four groups (n=10). these groups received normal saline (10mg/kg), ep (500mg/kg), levamisole (2mg/kg) and ep (500mg/kg) with levamisole (2mg/kg) as oral gavages every day for a period of 4weeks, respectively. after obtaining blood samples (at the end of each week), ... | 2010 | 20797737 |
| blocking effect of an immuno-suppressive agent, cynarin, on cd28 of t-cell receptor. | cynarin, a potential immunosuppressant that blocks the interaction between the cd28 of t-cell receptor and cd80 of antigen presenting cells, was found in echinacea purpurea by a new pharmaceutical screening method: after flowing through immobilized receptor (aftir; dong et al., j med chem, 49: 1845-1854, 2006). this echinacea component is the first small molecule that is able to specifically block "signal 2" of t-cell activation. | 2009 | 18989760 |
| echinacea increases arginase activity and has anti-inflammatory properties in raw 264.7 macrophage cells, indicative of alternative macrophage activation. | the genus echinacea is a popular herbal immunomodulator. recent reports indicate that echinacea products inhibit nitric oxide (no) production in activated macrophages. | 2009 | 19111603 |
| the effect of echinacea purpurea (l.) moench extract on experimental prostate hyperplasia. | the aim of this study was to examine the effect of purple coneflower (echinacea purpurea l. moench) on the prostate gland of rats using an experimental model of benign prostate hyperplasia (bph). the animals were administered 50 mg/kg of extract preparation for 4 and 8 weeks and the prostate mass and structural degenerative changes were evaluated in the course of the experiment. the administration of e. purpurea extract to rats with hyperplasia for 4 and 8 weeks gradually and significantly reduc ... | 2009 | 19288499 |
| synergistic immunomopharmacological effects of n-alkylamides in echinacea purpurea herbal extracts. | echinacea purpurea extracts are used in the production of standardized herbal medicines for the prevention and treatment of upper respiratory infections. unsaturated n-alkylamide lipids, the main constituent of e. purpurea and e. angustifolia preparations capable of activating the cannabinoid receptor type-2 (cb2) have been suggested to play a role as potential anti-inflammatory and immune-modulatory principles. here we show that ethanolic e. purpurea radix and herba extracts produce synergistic ... | 2009 | 19303464 |
| anthelmintic effects of phytogenic feed additives in ascaris suum inoculated pigs. | two experiments were performed to determine the anthelmintic effect of some phytogenic feed additives on a mild infection of ascaris suum in growing and finishing pigs. usually, an infection of a. suum is controlled by using conventional synthetic drugs. organic farmers, however, prefer a non-pharmaceutical approach to worm control. therefore, phytotherapy could be an appropriate alternative. in the first experiment, a commercial available organic starter diet was supplemented with 3% of a herb ... | 2010 | 19954891 |
| [knowledge of perioperative risk associated with use of medicinal plants]. | to assess physicians' knowledge of perioperative risk for patients who consume medicinal plants. to review interactions between drugs and the main medicinal plants with a view to justifying a plan for preoperative intervention. | 2009 | 19994614 |
| the efficacy of echinacea in a 3-d tissue model of human airway epithelium. | we evaluated the antirhinovirus efficacy of a standardized preparation of echinacea purpurea (echinaforce) in a 3-dimensional organotypic model of normal human airway epithelium (epiairway tissue). individual replicate tissue samples, maintained as inserts in culture for 3 days or 3 weeks, were infected with rhinovirus type 1a (rv1a), echinacea alone, a combination of the two, or medium only. none of the treatments affected the histological appearance or integrity of the tissues, all of which ma ... | 2010 | 19998417 |
| [new promising natural immunocorrective agents]. | the influence of sorbus sibirica, calendula officinalis and althaea officinalis extracts on the humoral immune response and nonspecific resistance of mice to immunosuppression by cyclophosphan was studied. it was shown that these extracts are not inferior to echinacea purpurea tincture in terms of stimulation of humoral immune response, phagocytic and bactericidal activity of peritoneal macrophages but exceed effect of e. purpurea on phagocytic activity of peripheral blood neutrophils. | 2009 | 20017400 |
| echinacea purpurea polysaccharide reduces the latency rate in herpes simplex virus type-1 infections. | during the latency period of herpes simplex virus type-1 (hsv-1), the virus can occasionally reactivate, travel back to the eye and cause recurrent ocular disease. as this condition arises from the ability of hsv-1 to produce a dormant infection, effective medication to prevent the virus enter a latent state should prevent it. in this study, we applied echinacea polysaccharide (ep) fraction as prophylactic mediator for latency prevention. | 2009 | 19372701 |
| echinacea purpurea extracts modulate murine dendritic cell fate and function. | echinacea is a top-selling herbal remedy that purportedly acts as an immunostimulant. however, the specific immunomodulatory effects of echinacea remain to be elucidated. we focused on defining the effects of echinacea purpurea extracts in dendritic cells (dcs), which generate innate and adaptive immune responses. we hypothesized that e. purpurea extracts would enhance murine bone marrow-derived dc (bmdc) activation leading to increased immune responses. the fate and function of dcs from c57bl/6 ... | 2010 | 20149833 |
| selection of natural health products for clinical trials: a preclinical template. | in preparation for a clinical trial on the efficacy of echinacea products with a pediatric population, a rational method for selection of test products was developed, based on phytochemical and bioassay evaluation. ten currently available commercial products of echinacea angustifolia (ea) or echinacea purpurea (ep) were selected, and 3 bottles of each of 2 different lots were purchased for each product. investigators were blinded to product identity before phytochemical analysis. lot-to-lot vari ... | 2009 | 19448735 |
| biological effects of echinacea purpurea on human blood cells. | the aim of this study was to investigate radioprotective properties of echinacea purpurea tablets in vivo. we analysed lymphocyte chromosome aberrations (ca), micronuclei (mn), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. all radiation workers were taking two 275 mg echinacea tablets b.i.d., according to a pharmacist's recommendation. all parameters were analysed before and after ... | 2009 | 19581209 |
| the effect of standardized echinacea purpurea extract on rat cytochrome p450 expression level. | it is claimed that application of botanical supplements or herbal medicinal products with synthetic drugs that are cytochrome p450 enzymes substrates may induce significant herb-drug interactions and may alter pharmacotherapy. echinacea preparations are one of the best selling products in the europe and their medicinal use is still increasing but data about interactions of echinacea extract with cyp enzymes are limited. in this study, we have investigated potential influence of standardized echi ... | 2010 | 20374973 |
| echinacea purpurea aerial extract alters course of influenza infection in mice. | influenza infection is a major clinical problem and echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. mice infected with wsn influenza a and treated with e. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. echinacea-treated mice had lower systemic and pulmonary kc and il-10 levels and lower systemic ifn-gamma levels following influenza infection. thes ... | 2010 | 20382242 |
| spontaneously reported adverse reactions in association with complementary and alternative medicine substances in sweden. | although the safety information is limited, use of complementary and alternative medicine (cam) products is not without risks. spontaneous reporting systems may be used in the surveillance of these products. we describe the pattern of spontaneously reported cam related adverse reactions submitted to the swedish medical products agency (mpa) and highlight areas of safety concern. | 2009 | 19650152 |
| prophylactic effects of echinacea purpurea polysaccharide against lethal ocular herpes simplex virus type i. | | 2008 | 18690323 |
| optimization and single-laboratory validation study of a high-performance liquid chromatography (hplc) method for the determination of phenolic echinacea constituents. | three species of echinacea (echinacea purpurea, echinacea angustifolia, and echinacea pallida) are commonly used for medicinal purposes. the phenolic compounds caftaric acid, cichoric acid, echinacoside, cynarin, and chlorogenic acid are among the phytochemical constituents that may be responsible for the purported beneficial effects of the herb. although methods for the analysis for these compounds have been published, documentation of their validity was inadequate as the accuracy and precision ... | 2010 | 20467727 |
| establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands. | cannabinoid receptors (cbr) are important drug targets for the treatment of various inflammatory, metabolic and neurological diseases. therefore, sensitive test systems for the assessment of ligands are needed. in this study, a steady-state gtpase assay for human cbr subtypes 1 and 2 was developed to characterize the pharmacological property of ligands at a very proximal point of the signal transduction cascade. establishing these in vitro test sytems, we studied cell or tissue membranes heterog ... | 2010 | 20617431 |
| use of heteroduplex mobility assay for identification and differentiation of phytoplasmas in the aster yellows group and the clover proliferation group. | abstract this paper describes the identification and differentiation of phytoplasmas by a highly sensitive diagnostic technique, dna heteroduplex mobility assay (hma). closely related phytoplasma isolates of clover proliferation (cp), potato witches'-broom (pwb), and alfalfa witches'-broom (awb) were collected from the field from 1990 to 1999. the entire 16s rrna gene and 16/23s spacer region were amplified by polymerase chain reaction (pcr) from the field samples and standard cp, pwb, and awb p ... | 2001 | 18943942 |
| endogenous levels of echinacea alkylamides and ketones are important contributors to the inhibition of prostaglandin e2 and nitric oxide production in cultured macrophages. | because of the popularity of echinacea as a dietary supplement, researchers have been actively investigating which echinacea constituent or groups of constituents are necessary for immune-modulating bioactivities. our prior studies indicate that alkylamides may play an important role in the inhibition of prostaglandin e2 (pge(2)) production. high-performance liquid chromatography fractionation, employed to elucidate interacting anti-inflammatory constituents from ethanol extracts of echinacea pu ... | 2009 | 19807154 |
| Evaluating the efficacy of cinnamaldehyde and Echinacea purpurea plant extract in broilers against Eimeria acervulina. | Coccidiostats could be phased out as feed additives before 1 January 2013 for public health and food safety reasons, and, as a replacement, bioactive compounds found in plants are currently being investigated since they are more likely to be found acceptable by consumers. The aim of our study was to evaluate the effect of cinnamaldehyde (CIN) and Echinacea purpurea plant extract (EP) as additives by analyzing the performance traits, oocyst excretion and intestinal lesions following experimental ... | 2011 | 21996002 |
| echinacea purpurea significantly induces cytochrome p450 3a activity but does not alter lopinavir-ritonavir exposure in healthy subjects. | . to determine the influence of echinacea purpurea on the pharmacokinetics of lopinavir-ritonavir and on cytochrome p450 (cyp) 3a and p-glycoprotein activity by using the probe substrates midazolam and fexofenadine, respectively. | 2010 | 20653355 |
| anti-viral properties and mode of action of standardized echinacea purpurea extract against highly pathogenic avian influenza virus (h5n1, h7n7) and swine-origin h1n1 (s-oiv). | influenza virus (iv) infections are a major threat to human welfare and animal health worldwide. anti-viral therapy includes vaccines and a few anti-viral drugs. however vaccines are not always available in time, as demonstrated by the emergence of the new 2009 h1n1-type pandemic strain of swine origin (s-oiv) in april 2009, and the acquisition of resistance to neuraminidase inhibitors such as tamiflu (oseltamivir) is a potential problem. therefore the prospects for the control of iv by existing ... | 2009 | 19912623 |
| in vitro cyp3a4 metabolism: inhibition by echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. | the in vitro cyp3a4 inhibition profiles of echinacea purpurea, st. john's wort and ketoconazole were evaluated by three different substrates: 7-benzyloxy-trifluoromethylcoumarin (bfc), 7-benzyloxyquinoline (bq) and testosterone. st. john's wort and ketoconazole produced similar inhibition profiles regardless of substrate. for e. purpurea, testosterone metabolism showed a much lower cyp3a4 inhibition (ic(50) 5394 microg/ml) compared to the fluorescent substrates bfc and bq (ic(50) 354 and 452 mg/ ... | 2008 | 18947363 |
| draft genome sequence of pseudomonas sp. eps/l25, isolated from the medicinal plant echinacea purpurea and able to synthesize antimicrobial compounds. | we announce here the draft genome sequence of pseudomonas sp. strain eps/l25, isolated from the stem/leaves of the medicinal plant echinacea purpurea this genome will allow for comparative genomics in order to identify genes associated with the production of bioactive compounds and antibiotic resistance. | 2016 | 27151804 |
| the effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of asteraceae family on the peroxynitrite-induced changes in blood platelet proteins. | lots of plants belonging to asteraceae family are very popular in folk medicine in poland. these plants are also known as being rich in acidic polysaccharides, due to the presence of hexuronic acids or its derivatives. our preliminary experiments have shown that the extract from conyza canadensis l. possesses various biological activity, including antiplatelet, antiocoagulant and antioxidant properties. the aim of our study was to assess if macromolecular glycoconjugates from selected herbal pla ... | 2010 | 20869393 |
| stimulatory effect of echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses. | several echinacea species have been used as nutraceuticals or botanical drugs for "immunostimulation", but scientific evidence supporting their therapeutic use is still controversial. in this study, a phytocompound mixture extracted from the butanol fraction (bf) of a stem and leaf (s+l) extract of e. purpurea ([bf/s+l/ep]) containing stringently defined bioactive phytocompounds was obtained using standardized and published procedures. the transcriptomic and proteomic effects of this phytoextrac ... | 2010 | 21040561 |
| echinacea purpurea: pharmacology, phytochemistry and analysis methods. | echinacea purpurea (asteraceae) is a perennial medicinal herb with important immunostimulatory and anti-inflammatory properties, especially the alleviation of cold symptoms. the plant also attracted scientists' attention to assess other aspects of its beneficial effects. for instance, antianxiety, antidepression, cytotoxicity, and antimutagenicity as induced by the plant have been revealed in various studies. the findings of the clinical trials are controversial in terms of side effects. while s ... | 2015 | 26009695 |
| response of two prairie forbs to repeated vole herbivory. | vertebrate herbivores as diverse as ungulates, geese, and rabbits preferentially feed on plants that have previously experienced herbivory. here, we ask whether smaller grassland "cryptic consumers" such as voles (microtus ochrogaster and m. pennsylvanicus) preferentially clip (cut stems for access to leaves or seeds) or avoid previously clipped individuals of two tallgrass prairie species (desmanthus illinoensis and echinacea purpurea) within a growing season. further, we ask how these plants r ... | 2010 | 21053022 |
| correlation of xmap and elisa cytokine profiles; development and validation for immunotoxicological studies in vitro. | there is an emerging trend in immunotoxicological studies to use the multiplex technologies for testing the safety and the efficacy of new pharmaceuticals by using cytokines profiling as biomarker. the luminex 200 xmap (multi-analyte profiling) technology provides simultaneous measurement of multiple cytokines in small sample volumes, expressing rapidly the differences between various test compounds. the aim is to develop and validate the luminex 200 multiplex immunoassays by correlation with el ... | 2010 | 21053779 |
| herb-drug interaction between echinacea purpurea and darunavir-ritonavir in hiv-infected patients. | the aim of this open-label, fixed-sequence study was to investigate the potential of echinacea purpurea, a commonly used botanical supplement, to interact with the boosted protease inhibitor darunavir-ritonavir. fifteen hiv-infected patients receiving antiretroviral therapy including darunavir-ritonavir (600/100 mg twice daily) for at least 4 weeks were included. e. purpurea root extract capsules were added to the antiretroviral treatment (500 mg every 6 h) from days 1 to 14. darunavir concentra ... | 2010 | 21078942 |
| preliminary data on antibacterial activity of echinacea purpurea-associated bacterial communities against burkholderia cepacia complex strains, opportunistic pathogens of cystic fibrosis patients. | burkholderia cepacia complex bacteria (bcc) represent a serious threat for immune-compromised patient affected by cystic fibrosis (cf) since they are resistant to many substances and to most antibiotics. for this reason, the research of new natural compounds able to inhibit the growth of bcc strains has raised new interest during the last years. a source of such natural compounds is represented by medicinal plants and, in particular, by bacterial communities associated with these plants able to ... | 2017 | 28164789 |
| echinacea-induced cytosolic ca2+ elevation in hek293. | with a traditional medical use for treatment of various ailments, herbal preparations of echinacea are now popularly used to improve immune responses. one likely mode of action is that alkamides from echinacea bind to cannabinoid type 2 (cb2) receptors and induce a transient increase in intracellular ca2+. here, we show that unidentified compounds from echinacea purpurea induce cytosolic ca2+ elevation in non-immune-related cells, which lack cb2 receptors and that the ca2+ elevation is not influ ... | 2010 | 21092239 |
| a sensitive lc-ms/ms method for the quantitative analysis of the echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma. | echinacea purpurea is one of the most popular herbal medicines and is known for its immunostimulatory effects. alkylamides are the main lipophilic components of e. purpurea that contribute to its pharmacological actions. for quantification in human plasma of one of these alkylamides, undeca-2-ene-8,10-diynoic acid isobutylamide, a sensitive lc-ms/ms assay has been developed and validated. plasma samples were pretreated using liquid-liquid extraction with a mixture of diethyl ether and n-hexane ( ... | 2010 | 21123121 |
| effects of phenytoin and echinacea purpurea extract on proliferation and apoptosis of mouse embryonic palatal mesenchymal cells. | cleft palate is one of the most common birth defects. several environment factors are involved in the disorder, such as smoking, vitamin deficiency and teratogens. we investigated the teratogenic agent phenytoin and extract of the immunostimulant echinacea purpurea in the etiology of cleft palate associated with the proliferation and apoptosis of mouse embryonic palatal mesenchymal (mepm) cells. we measured the effects of phenytoin, e. purpurea extract, and the mixture of phenytoin and e. purpur ... | 2011 | 21312240 |
| complementary and alternative medicine for prevention and treatment of the common cold. | to review the evidence supporting complementary and alternative medicine approaches to treatment and prevention of the common cold in adults. | 2011 | 21322286 |
| effect of high pressure pasteurization on bacterial load and bioactivity of echinacea purpurea. | high hydrostatic pressure (hhp) technology was applied to organic echinacea purpurea (e. purpurea) roots and flowers to determine the feasibility of using this technology for cold herb pasteurization, to produce microbiologically safe and shelf-stable products for the natural health products (nhps) industry. hhp significantly (p < 0.01) reduced microbial contamination in both roots and flowers without affecting the phytochemical retention of chicoric and chlorogenic acids, and total alkamide con ... | 2010 | 21535527 |
| absolute/relative bioavailability and metabolism of dodeca-2e,4e,8z,10e/z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats. | the present study assessed the absolute and relative bioavailabilities of dodeca-2 e,4 e,8 z,10 e/ z-tetraenoic acid isobutylamides (tetraenes), the main bioactive constituents in echinacea, administered as pure compounds or in the form of an echinacea purpurea root extract preparation. tetraenes were administered orally by gavage or intravenously in a dose of 0.75 mg/kg. the extract was administered orally in a dose of 158.6 mg/kg which corresponds to the same amount of tetraenes. pharmacokinet ... | 2011 | 21604240 |
| alkamides and a neolignan from echinacea purpurea roots and the interaction of alkamides with g-protein-coupled cannabinoid receptors. | multiple chromatographic separations of the chcl(3)-soluble extract of the roots of echinacea purpurea led to the isolation of 19 compounds. four natural products, three alkamides and nitidanin diisovalerianate, were identified, and five further compounds were detected for the first time in this species. additionally, 10 known e. purpurea metabolites were isolated. the structures were determined by mass spectrometry and advanced 1d and 2d nmr techniques. the bioactivity of the isolated compounds ... | 2011 | 21764086 |
| dose-dependent in vivo effect of rhodiola and echinacea on the mitogen-induced lymphocyte proliferation in mice. | echinacea purpurea (ep) and echinacea angustifolia (ea) are ones of the most important world's herbs with immunotropic activity. they were traditional medicinal plants used by north american indians for the treatment of various illnesses. now they are cultivated in many countries and are used mainly to treat respiratory tract infections. rhodiola rosea (rr) and rhodiola quadrifida (rq) are medicinal plants originated from asia and used traditionally as adaptogens, antidepressants, and anti-infla ... | 2011 | 21721412 |
| Chromatographic Methods for Metabolite Profiling of Virus- and Phytoplasma-Infected Plants of Echinacea purpurea. | This study was focused on the effects of virus and phytoplasma infections on the production of Echinacea purpurea (L.) Moench secondary metabolites, such as caffeic acid derivatives, alkamides, and essential oil. The identification of caffeic acid derivatives and alkamides was carried out by means of high-performance liquid chromatography-diode array detection (HPLC-DAD), HPLC-electrospray ionization-mass spectrometry (ESI-MS), and MS(2). Quantitative analysis of these compounds was carried out ... | 2011 | 21830789 |
| Neuroprotective effects of a new skin care formulation following ultraviolet exposure. | Background: Chronic ultraviolet (UV) exposure is a major environmental factor involved in extrinsic skin ageing (photo-ageing). Skin nerve fibres are significantly reduced in number following UV irradiation and new skincare compounds with neuroprotective effects are thus highly warranted. Objectives: We developed a new skincare formulation from a plant extract and evaluated its neuroprotective effects of ex vivo UV irradiation. Materials and methods: The new skincare emulsion was formulated f ... | 2011 | 22151837 |
| Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression. | This study aimed to shed light on the anti-inflammatory and hepatoprotective effect of the major alkamides dodeca-2E,4E,8Z,10Z(E)-tetraenoic acid isobutylamides (Alk-8/9), isolated from Echinacea purpurea roots, against acute fulminant hepatitis induced by lipopolysaccharide/D-galactosamine (LPS/D-GalN) in mice. The results show that Alk-8/9 dose-dependently induced heme oxygenase (HO)-1 protein expression in LPS-stimulated murine macrophages that was likely regulated by the JNK-mediated pathway ... | 2011 | 21985290 |
| Plasma caffeic acid is associated with statistical clustering of the anticolitic efficacy of caffeic acid in dextran sulfate sodium-treated mice. | We hypothesized that interindividual variability in the bioavailability of caffeic acid (CA) would influence its anticolitic efficacy and that mice may be appropriate for modeling human gut microbial metabolism of CA, which is thought to influence CA bioavailability. Anaerobic human fecal and mouse cecal sample mixtures were incubated with CA derivatives from Echinacea purpurea and compound disappearance rates were measured, which were similar in both sample types. CA metabolism, including forma ... | 2011 | 21918060 |
| determination of major phenolic compounds in echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension. | a method previously validated to determine caftaric acid, chlorogenic acid, cynarin, echinacoside, and cichoric acid in echinacea raw materials has been successfully applied to dry extract and liquid tincture products in response to north american consumer needs. single-laboratory validation was used to assess the repeatability, accuracy, selectivity, lod, loq, analyte stability (ruggedness), and linearity of the method, with emphasis on finished products. repeatability precision for each phenol ... | 2011 | 22165004 |
| Production of biomass and useful compounds from adventitious roots of high-value added medicinal plants using bioreactor. | The increasing global demand for biomass of medicinal plant resources reflects the issues and crisis created by diminishing renewable resources and increasing consumer populations. Moreover, diverse usage of plants and reduced land for cultivation in the world accelerated the deficiency of plant resources. In addition, the preparation of safety of plant based medicine whips up demand for biomass of valuable medicinal plants. As one of alternative approach to upswing the productivity of plant-bas ... | 2011 | 22123438 |
| effects of chemically characterized fractions from aerial parts of echinacea purpurea and e. angustifolia on myelopoiesis in rats. | echinacea species are used for beneficial effects on immune function, and various prevalent phytochemicals have immunomodulatory effects. using a commercial e. purpurea (l.) moench product, we have evaluated the myelopoietic effect on bone marrow of rats treated with various extracts and correlated this with their chemical class composition. granulocyte/macrophage-colony forming cells (gm-cfcs) from femurs of female sprague-dawley rats were assessed at 24 h after 7 daily oral treatments. a 75% e ... | 2011 | 21870322 |
| effects of drugs of plant origin on the development of the immune response. | the effects of extracts from licorice (glycyrrhisa glabra), great nettle (urtica dioica), common burdock (arctium lappa), and bur marigold (bidens tripartite) on the humoral and cellular immune response and nonspecific resistance in mice were studied. burdock and bur marigold extracts stimulated the humoral immune response, nettle and licorice extracts stimulated cellular response and nonspecific resistance, their effects being superior to those of pharmacopoeial echinacea purpurea tincture. | 2011 | 22238748 |
| echinacea and its alkylamides: effects on the influenza a-induced secretion of cytokines, chemokines, and pge₂ from raw 264.7 macrophage-like cells. | the goal of this study was to determine whether extracts and isolated alkylamides from echinacea purpurea would be useful for prevention of the inflammatory response that accompanies infections with h1n1 influenza a. seventeen extracts and 4 alkylamides were tested for the ability to inhibit production of cytokines, chemokines, and pge₂ from raw 264.7 macrophage-like cells infected with the h1n1 influenza a strain pr/8/34. the alkylamides undeca-2z,4e-diene-8,10-diynic acid isobutylamide, dodeca ... | 2010 | 20674883 |
| the potential use of echinacea in acne: control of propionibacterium acnes growth and inflammation. | acne is a chronic inflammatory disorder of skin follicles caused by the gram-positive bacterium propionibacterium acnes. the possibility was investigated that a standardized preparation of echinacea purpurea (echinaforce®), with known antiviral, antiinflammatory and antibacterial properties, might provide a useful alternative treatment in the control of the disease. the herbal extract readily killed a standard laboratory strain of the bacterium and several clinical isolates. in cell culture mode ... | 2011 | 20830697 |
| evaluation of immunopathologic effects of aqueous extract of echinacea purpurea in mice after experimental challenge with pasteurella multocida serotype a. | in order to assess the immunopathological effects of aqueous echinacea purpurea extract (epe) on mice experimentally challenged with pasteurella multocida serotype a, forty female balb/c mice were randomly divided into four groups. the groups included a control group (received sterile distilled water 2 times/week for 2 weeks, intraperitoneally and then 100 µl sterile saline intranasally), a pma group (received sterile distilled water as the control group and after 2 weeks, 5.6 × 10(3) cfu/ml of ... | 2014 | 27175135 |
| phenotypic and genomic characterization of the antimicrobial producer rheinheimera sp. eprs3 isolated from the medicinal plant echinacea purpurea: insights into its biotechnological relevance. | in recent years, there has been increasing interest in plant microbiota; however, despite medicinal plant relevance, very little is known about their highly complex endophytic communities. in this work, we report on the genomic and phenotypic characterization of the antimicrobial compound producer rheinheimera sp. eprs3, a bacterial strain isolated from the rhizospheric soil of the medicinal plant echinacea purpurea. in particular, eprs3 is able to inhibit growth of different bacterial pathogens ... | 2017 | 27884784 |
| agrobacterium rhizogenes-mediated transformation of echinacea purpurea. | echinacea purpurea seedlings were inoculated with several agrobacterium rhizogenes strains in order to obtain hairy roots. infection with a. rhizogenes strains lmg63 and lmg150 resulted in callus formation. upon infection with strains atcc 15834 and r1601 hairy roots were obtained. opine detection confirmed transformation of e. purpurea. comparative hplc fingerprint analysis of the alkamides from natural plant source, control tissues, and transformed callus and roots indicated that transformed c ... | 1991 | 24221400 |
| molecular phylogeny, diversity, and bioprospecting of endophytic fungi associated with wild ethnomedicinal north american plant echinacea purpurea (asteraceae). | the endophytic fungal community associated with the ethnomedicinal plant echinacea purpurea was investigated as well as its potential for providing antifungal compounds against plant pathogenic fungi. a total of 233 endophytic fungal isolates were obtained and classified into 42 different taxa of 16 genera, of which alternaria alternata, colletotrichum dematium, and stagonosporopsis sp. 2 are the most frequent colonizers. the extracts of 29 endophytic fungi displayed activities against important ... | 2016 | 27273012 |
| expression, immunogenicity and diagnostic value of envelope proteins from an egyptian hepatitis c virus isolate. | the present work aimed at 1) characterization of the e1 and e2 proteins (hcv-e) from an egyptian hepatitis c virus genotype 4a (hcv-4a) isolate at the molecular and immunological level, 2) in silico identification of the b- and t-cell epitopes responsible for the immunogenicity of hcv-e, and 3) evaluation of the diagnostic potential of both the recombinant hcv-e and antibodies raised using mammalian expression constructs encoding the protein. the region encoding the e1 and e2 proteins was amplif ... | 2015 | 25631616 |
| in vivo screening of four phytochemicals/extracts and a fungal immunomodulatory protein against an eimeria acervulina infection in broilers. | besides the anticoccidial drug resistance problem, increasing consumer concerns about food safety and residues have propelled the quest for alternative prevention and control strategies amongst which phytotherapy has gained appeal due to a renewed interest in natural medicine. | 2013 | 24161027 |
| in vitro inhibition of eimeria tenella invasion of epithelial cells by phytochemicals. | resistance to coccidiostats and possible future restrictions on their use raise the need for alternative methods of reducing coccidiosis in poultry. the aim of this study was to evaluate the effect of selected phytochemicals on eimeria tenella sporozoite invasion in vitro. four phytochemicals were selected on the basis that they reduce the virulence of eimeria spp. and/or provide immune modulatory benefits to host cells: betaine, carvacrol, curcumin and echinacea purpurea extract (ep). madin-dar ... | 2013 | 23021265 |
| in vivo screening of five phytochemicals/extracts and a fungal immunomodulatory protein against colibacillosis in broilers. | five phytochemicals/extracts (an extract from echinacea purpurea, a β-glucan-rich extract from shiitake, betaine [betain™], curcumin from curcuma longa [turmeric] powder, carvacrol and also a recombinant fungal immunomodulatory protein [fip] from ganoderma lucidum) cloned and expressed in escherichia coli were investigated for their anticolibacillosis potential in three chicken experiments, which were conducted in floor pens. birds that were inoculated with e. coli intratracheally were treated w ... | 2013 | 23627727 |
| effect of dietary supplementation with echinacea purpurea on vaccine efficacy against infection with flavobacterium columnare in zebrafish (danio rerio). | the effect of dietary echinacea purpurea (ep) on the response of zebrafish (danio rerio) to a flavobacterium columnare vaccine was investigated. two hundred d. rerio with an average weight of 290 ± 40 g were selected and fed different levels of e. purpurea (5 g kg(-1) diet--group 1, 10 g kg(-1) diet--group 2, 20 g kg(-1) diet--group 3, 30 g kg(-1) diet--group 4, and 0 g kg(-1) diet--group 5). experimental feeding was begun 3 weeks prior to bath immunization and continued until the end of the exp ... | 2014 | 25638970 |
| prevention of influenza virus induced bacterial superinfection by standardized echinacea purpurea, via regulation of surface receptor expression in human bronchial epithelial cells. | viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may c ... | 2017 | 28279802 |
| lactic acid fermentation as a tool to enhance the functional features of echinacea spp. | extracts and products (roots and/or aerial parts) from echinacea ssp. represent a profitable market sector for herbal medicines thanks to different functional features. alkamides and polyacetylenes, phenols like caffeic acid and its derivatives, polysaccharides and glycoproteins are the main bioactive compounds of echinacea spp. this study aimed at investigating the capacity of selected lactic acid bacteria to enhance the antimicrobial, antioxidant and immune-modulatory features of e. purpurea w ... | 2013 | 23642310 |
| effect of hydroalcoholic extract of echinacea purpurea in combination with meglumine antimoniate on treatment of leishmania major-induced cutaneous leishmaniasis in balb/c mice. | progressive resistance of leishmania parasite to available drugs including, meglumine antimoniate, has been reported from various regions of the world, especially iran. | 2017 | 28251109 |
| effects of extracts from echinacea purpurea (l) moench on mice infected with different strains of toxoplasma gondii. | in recent years, due to the growing concern about recurrent epidemics by toxoplasma gondii and other pathogens in brazil, there has been an increase in the use of different preparations obtained from echinacea purpurea in order to test their effectiveness against these infections. although studies have suggested the beneficial effects of this species against the influenza virus, no data are available on the use of e. purpurea aqueous extract in t. gondii infections. thus, the aim of this study w ... | 2016 | 27277433 |
| the antioxidant effect of echinacea angustifolia and echinacea purpurea in rat colitis model induced by acetic acid. | ulcerative colitis is a chronic inflammatory condition of the colon, and reactive oxidative metabolites (roms) play an important role in its pathogenesis. alternative therapies such as herbal remedies are increasingly being used in the treatment of ulcerative colitis for better clinical outcome of ulcerative colitis and less adverse effects. echinacea has many features including antioxidant and wound-healing properties. hence, the present study was undertaken to evaluate the protective effect of ... | 2014 | 25077363 |
| milk thistle's active components silybin and isosilybin: novel inhibitors of pxr-mediated cyp3a4 induction. | because cancer is often treated with combination therapy, unexpected pharmacological effects can occur because of drug-drug interactions. several drugs are able to cause upregulation or downregulation of drug transporters or cytochrome p450 enzymes, particularly cyp3a4. induction of cyp3a4 may result in decreased plasma levels and therapeutic efficacy of anticancer drugs. since the pregnane x receptor (pxr) is one of the major transcriptional regulators of cyp3a4, pxr antagonists can possibly pr ... | 2013 | 23674609 |
| treatment of the common cold in children and adults. | the common cold, or upper respiratory tract infection, is one of the leading reasons for physician visits. generally caused by viruses, the common cold is treated symptomatically. antibiotics are not effective in children or adults. in children, there is a potential for harm and no benefits with over-the-counter cough and cold medications; therefore, they should not be used in children younger than four years. other commonly used medications, such as inhaled corticosteroids, oral prednisolone, a ... | 2012 | 22962927 |
| phenotyping studies to assess the effects of phytopharmaceuticals on in vivo activity of main human cytochrome p450 enzymes. | the extensive use of herbal drugs and their multiple components and modes of action suggests that they may also cause drug interactions by changing the activity of human cytochrome p450 enzymes. the purpose of the present review is to present the available data for the top 14 herbal drug sales in the u. s. studies describing the effects of herbal drugs on phenotyping substrates for individual cyps were identified by a comprehensive medline search. drugs included allium sativum (liliaceae), echin ... | 2012 | 22588833 |
| [immunostimulating action of polysaccharides (heteroglycans) from higher plants]. | from the water or alcaline-water extracts of echinacea purpurea (l.) moench. and -angustifolia dc., eupatorium cannabium l. and -perfoliatum l., chamomilla recutita l. rauscher, calendula officinalis l., baptisia tinctoria (l.) r. b., achyrocline satureioides dc., arnica montana l., sabal serrulata roem. et schult., and eleutherococcus (acanthopanax) senticosus maxim. polysaccharide fractions with molecular weights in the range of 25 000 to 500 000 and higher have been isolated, which, according ... | 1985 | 4052142 |
| the effect of echinacea purpurea, astragalus membranaceus and glycyrrhiza glabra on cd25 expression in humans: a pilot study. | this phase 0, double-blind, repeated within subject, randomized pilot study examined cd25 expression on t cells after ingestion of three commonly used herbs: echinacea purpurea, astragalus membranaceus and glycyrrhiza glabra, administered singly and in combination. cd25 expression on t cells was significantly increased for subjects ingesting echinacea at 24 h with notable increases in activation from astragalus and glycyrrhiza. cd25 expression remains elevated with daily use of echinacea for at ... | 2007 | 17661330 |
| [induction of adventitious roots of echinacea pallida and accumulation of caffeic acid derivatives]. | to investigate the effect of auxins 2,4-d,iaa,iba,naa on induction of adventitious roots as well as that of iba concentrations on the growth of adventitious roots and the accumulation of caffeic acid derivatives, with test-tube seedling leaves echinacea pallida as the explant, and cultivate adventitious roots in bioreactors. | 2012 | 23627176 |
| applications of the phytomedicine echinacea purpurea (purple coneflower) in infectious diseases. | extracts of echinacea purpurea (ep, purple coneflower) have been used traditionally in north america for the treatment of various types of infections and wounds, and they have become very popular herbal medicines globally. recent studies have revealed that certain standardized preparations contain potent and selective antiviral and antimicrobial activities. in addition, they display multiple immune-modulatory activities, comprising stimulation of certain immune functions such as phagocytic activ ... | 2011 | 22131823 |
| an on-line hplc system for detection of antioxidant compounds in some plant extracts by comparing three different methods. | echinacea (echinacea purpurea), green tea (camellia sinensis) and yaylacayi (thymus praecox opiz subsp. grossheimii (ronniger) jalas) are herbs used in traditional medicine because of their beneficial health effects. a high performance liquid chromatography (hplc) post-column method was developed by coupling hplc with on-line antioxidant assays using diode array (dad) and ultraviolet (uv) detectors. thus antioxidant compounds and fifteen phenolic standards were detected in echinacea, green tea a ... | 2017 | 28359985 |
| echinacea pupurea extracts promote murine dendritic cell maturation by activation of jnk, p38 mapk and nf-κb pathways. | dendritic cells (dcs) comprise a system of highly professional antigen presenting cells (apcs) which connect innate and adaptive immunity by undergoing dramatic shift in their maturation state. phytomedicine echinacea purpurea extracts (ee) could modulate murine dendritic cell fate and function. however, the underlying mechanism of ee on dcs development and maturation remains limited. in this study, immature dcs were induced phenotypic maturation with up-regulated expression of key accessory mol ... | 2017 | 28263837 |
| chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nf-κb. | chicoric acid (ca), a natural phenolic acid extracted from chicory and the echinacea (purple coneflower) plant (echinacea purpurea), has been regarded as a nutraceutical that has powerful antioxidant and antiobesity activities. we investigated the inhibitory effects of ca on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment. c57bl/6j mice were treated with 0.05% ca in the drinking water for 45 d. the mice were then treated by intraperitoneal injection of ... | 2017 | 28003341 |
| echinacea purpurea extract polarizes m1 macrophages in murine bone marrow-derived macrophages through the activation of jnk. | echinacea purpurea is an indigenous north american purple cone flower used by north americans for treatment of various infectious diseases and wounds. this study investigated the effect of polysaccharide enriched extract of echinacea purpurea (ee) on the polarization of macrophages. the results showed that 100 µg/ml of ee could markedly activate the macrophage by increasing the expression of cd80, cd86, and mhcii molecules. meanwhile, ee upregulated the markers of classically activated macrophag ... | 2017 | 28067413 |
| antioxidant, antidiabetic, and antihypertensive properties of echinacea purpurea flower extract and caffeic acid derivatives using in vitro models. | the extraction yield, total phenols, caffeic acid derivatives (cad), and antioxidant properties of 50% ethanolic echinacea purpurea flower extract were determined. the in vitro inhibitory effects of 50% ethanolic extract and cad on α-amylase, α-glucosidase, and angiotensin-converting enzyme (ace) linked with type 2 diabetes were also investigated. the extraction yield, total phenols, and total cad of the extract were 27.04%, 195.69 mg cae/g and 78.42 mg/g, respectively. cichoric acid (56.03 mg/g ... | 2017 | 28061036 |
| effect of chicoric acid on mast cell-mediated allergic inflammation in vitro and in vivo. | chicoric acid (dicaffeoyl-tartaric acid), is a natural phenolic compound found in a number of plants, such as chicory (cichorium intybus) and echinacea (echinacea purpurea), which possesses antioxidant, anti-inflammatory, antiviral, and analgesic activities. although these biological effects of chicoric acid have been investigated, there are no reports of its antiallergic-related anti-inflammatory effects in human mast cells (hmc)-1 or anaphylactic activity in a mouse model. therefore, we invest ... | 2015 | 26593037 |
| cichoric acid reverses insulin resistance and suppresses inflammatory responses in the glucosamine-induced hepg2 cells. | cichoric acid, a caffeic acid derivative found in echinacea purpurea, basil, and chicory, has been reported to have bioactive effects, such as anti-inflammatory, antioxidant, and preventing insulin resistance. in this study, to explore the effects of ca on regulating insulin resistance and chronic inflammatory responses, the insulin resistance model was constructed by glucosamine in hepg2 cells. ca stimulated glucosamine-mediated glucose uptake by stimulating translocation of the glucose transpo ... | 2015 | 26592089 |
| [technology and analysis of "askoeziuofito" tablets]. | the objective of this work is to produce chewable tablets out of echinacea purpurea liquid extract (1:1) and ascorbic acid: to create the technology, to select methods of analysis and to examine stability. the paper describes the technology of tablets: a method of condensation is chosen; the influence of additional substances over tableting is established; pressing characteristics of tableting mixtures are examined. the quality of tablets is evaluated in terms of appearance and technological rat ... | 2003 | 14617854 |
| arthrobacter sp. eprs66 and arthrobacter sp. eprs71: draft genome sequences from two bacteria isolated from echinacea purpurea rhizospheric soil. | | 2016 | 27672382 |
| [estimation of maximum acceptable concentration of lead and cadmium in plants and their medicinal preparations]. | heavy metals (lead, cadmium) are possible dashes which quantity is defined by the limiting acceptable contents. different drugs preparations: infusions, decoctions, tinctures, extracts, etc. are produced using medicinal plants. the objective of this research was to study the impurities of heavy metals (lead, cadmium) in medicinal plants and some drug preparations. | 2003 | 14617871 |
| plant polysaccharides attenuate fluorouracil toxicity for the small intestinal epithelium. | polysaccharides from tussilago farfara l., acorus calamus l., and echinacea purpurea (l.) moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with lewis lung carcinoma. addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. no stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed. | 2016 | 27383155 |
| [study on salt tolerance of echinacea purpurea]. | to explore the salt tolerance of echiancea purpurea and its mechanism. | 2015 | 27352527 |
| corrigendum to "evaluation of a salmonella enteritidis vaccine and related elisa for respective induction and assessment of acquired immunity to the vaccine and/or echinacea purpurea in awassi ewes" [vaccine 33 (2015) 2228-2231]. | | 2016 | 27329183 |
| determination of toxic metals by icp-ms in asiatic and european medicinal plants and dietary supplements. | the potentially toxic metals content was determined in selected plants, used in traditional chinese medicine (angelica sinensis, bacopa monnieri, bupleurum sinensis, curcuma longa, cola accuminata, emblica officinalis, garcinia cambogia, mucuna pruriens, ocimum sanctum, panax ginseng, pueraria lobata, salvia miltiorrhiza, schisandra sinensis, scutellaria baicalensis, siraitia grosvenorii, terminalia arjuna and terminalia chebula), and some european herbs (echinacea purpurea, hypericum perforatum ... | 2015 | 25467854 |
| authentication of herbal supplements using next-generation sequencing. | dna-based testing has been gaining acceptance as a tool for authentication of a wide range of food products; however, its applicability for testing of herbal supplements remains contentious. | 2016 | 27227830 |
| a natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients. | sarcoidosis is a systemic inflammatory disease with abnormally high angiogenic activity of inflammatory cells. reumaherb preparation consisting of three herbs: echinacea purpurea, harpagophytum procumbens, and filipendula ulmaria, and it exerts anti-inflammatory, antioxidant, and analgesic activity and stimulates regenerative and immunological processes. the aim of this paper was to estimate the effect of reumaherb on immunological angiogenesis induced by bronchoalveolar lavage (bal) cells colle ... | 2016 | 27095919 |
| the modulatory influence of some echinacea-based remedies on antibody production and cellular immunity in mice. | echinacea purpurea-containing remedies are herbal medicines used in respiratory tract infections and several inflammatory conditions as enhancers of non-specific and modulators of specific cellular immunity. they also exert anti-inflammatory, anti-viral, and anti-microbial activity. the aim of the present study was to compare the in vivo influence of orally administered three echinacea purpurea-based remedies (immunal drops, echinacea forte drops, immunal forte tablets) on some parameters of cel ... | 2016 | 27095917 |
| studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of echinacea purpurea and echinacea angustifolia extracts. | echinacea (asteraceae) is used because of its pharmacological properties. however, there are few studies that integrate phytochemical analyses with pharmacological effects. | 2017 | 27951745 |
| proliferative activity of a blend of echinacea angustifolia and echinacea purpurea root extracts in human vein epithelial, hela, and qbc-939 cell lines, but not in beas-2b cell lines. | echinacea is used for its immunostimulating properties and may have a role in modulating adverse immune effects of chemotherapy (i.e., use of 5-fluorouracil (5-fu); fluorouracil and its immunosuppressive effect). patients may seek herbal remedies such as echinacea (echinacea angustifolia and echinacea purpurea) for immune stimulation. echinacea extracts have been prescribed to supplement cancer chemotherapy for their immune-supportive effects; however, the extracts may also influence tumourgenes ... | 2016 | 27114944 |
| fractionation and evaluation of proteins in roots of echinacea purpurea (l.) moench. | echinacea purpurea (l.) moench, a member of the asteraceae family, is a plant rich in flavonoids, essential oils, phenolic compounds, saponins, polysaccharides and glycoproteins. the aim of the study was to evaluate the protein content in dried roots of echinacea purpurea (l.) moench after homogenization of roots with liquid nitrogen, extraction in 0.01 mol l-1 phosphate-buffered saline (pbs) and purification followed by fractionation of proteins using gel filtration chromatography. total concen ... | 2015 | 26677903 |