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[scabies of the nail unit in an infant].there are no guidelines regarding the management of scabies in infants and recurrence is common at this age. we report the case of an infant with subungual hyperkeratosis and ungual lesions subsequent to classic scabies.201728063594
a scabies outbreak in a diabetic and collagen disease ward: management and prevention.scabies is an infection caused by sarcoptes scabiei. in developed countries, scabies remains an important public health problem in hospitals and care facilities among elderly or immunocompromised patients. there are a number of medical providers who have not experienced scabies and there has been confusion surrounding its management and prevention. therefore, the aim of the present study was to identify the optimal approach for the management and prevention of scabies. a scabies outbreak occurre ...201628105102
new techniques to collect live sarcoptes scabiei and evaluation of methods as alternative diagnostics for infection.sarcoptes scabiei is a widespread, highly contagious skin disease that affects many mammals including humans. the biological characteristics of s. scabiei remain unclear. therefore, the ability to collect adequate amount of mites for studies is required to advance our understanding of the parasite. the present study aimed to find a method to collect an adequate amount of live s. scabiei mites within a short time frame. the cornified layer and fur from an infected raccoon dog were inserted into a ...201728124136
use of remote cameras to monitor the potential prevalence of sarcoptic mange in southern texas, usa.sarcoptic mange, caused by the mite sarcoptes scabiei , is a common, highly contagious skin disease that has been reported from more than 100 species of mammals, including humans. our objectives were to 1) determine the prevalence of sarcoptic mange within mammals from southern texas, and 2) determine the efficacy of using remote cameras to estimate mange prevalence. we collected remote camera photographs from a 64-km(2) area and blood and skin scrapings from 166 mammals representing 12 species ...201728135133
scabies in a bilateral hand allograft recipient: an additional mimicker of acute skin rejection in vascularized composite allotransplantation.vascularized composite tissue allografts include skin, which frequently undergoes, in the early post-graft period, acute rejections. the diagnosis of acute rejection may be difficult as it can be mimicked by several dermatoses. we present a bilateral hand allograft recipient who developed, 16.5 years post-graft, cutaneous lesions raising suspicion about rejection. physical examination and skin biopsy were diagnostic of scabies. this ectoparasitosis should be added in the list of dermatoses that ...201728211139
complement inhibition by sarcoptes scabiei protects streptococcus pyogenes - an in vitro study to unravel the molecular mechanisms behind the poorly understood predilection of s. pyogenes to infect mite-induced skin lesions.on a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. there is substantial epidemiological evidence that in tropical regions scabies is often causing pyoderma and subsequently serious illness due to invasion by opportunistic bacteria. the health burden due to complicated scabies causing cellulitis, bacteraemia and sepsis, heart and kidney diseases in resource-poor communities is extre ...201728278252
numerical responses by populations of red fox and mountain hare during an outbreak of sarcoptic mange.during a severe outbreak of sarcoptic mange (sarcoptes scabiei vulpes) starting among red foxes (vulpes vulpes) in sweden in the 1970s, we studied: 1) the establishment and spread of the disease in northernmost sweden (by inquiries), and 2) the 1970-84 bag records for foxes and mountain hares (lepus timidus) (an alternative prey to the fox's main prey, voles). since the first case of sarcoptic mange in 1975 the disease spread rapidly, with >50% of the hunting organizations having reported the di ...198728311970
more bark than bite: comparative studies are needed to determine the importance of canine zoonoses in aboriginal communities. a critical review of published research.the objective of this review was to identify and critique over forty years of peer-reviewed literature concerned with the transmission of canine zoonoses to aboriginal people and determine the zoonotic organisms documented in dogs in australian aboriginal communities. a systematic literature search of public health, medical and veterinary databases identified 19 articles suitable for critical appraisal. thirteen articles documented the occurrence of recognized zoonotic organisms in dogs in abori ...201728342271
transcriptomics and proteomic studies reveal acaricidal mechanism of octadecanoic acid-3, 4 - tetrahydrofuran diester against sarcoptes scabiei var. cuniculi.in our previous study, a new compound, octadecanoic acid-3, 4-tetrahydrofuran diester, possessing potent acaricidal activity was obtained from neem oil. this study performed rna-seq transcriptomics and itraq proteomics to uncover the acaricidal mechanism of the compound against sarcoptes scabiei var. cuniculi. the results of transcriptomics indicated that after treatment with octadecanoic acid-3, 4-tetrahydrofuran diester, genes related to "energy metabolism" were significantly up-/down-regulate ...201728361965
misdiagnosed crusted scabies in an aids patient leads to hyperinfestation.crusted scabies is a severe, highly contagious form of classic scabies caused by the mite sarcoptes scabiei var hominis. crusted scabies is more common in immunosuppressed populations and overcrowded environments. in this condition, the host's immune system is overwhelmed and unable to defend against the mites on the skin, resulting in hyperinfestation of the host. diagnosis can be challenging because the condition resembles other common skin conditions, such as plaque psoriasis. furthermore, de ...201728398415
[scabies]. 201728417383
laboratory diagnosis of scabies using a simple saline mount: a clinical microbiologist's report.scabies is a skin condition caused by infestation of the mite sarcoptes scabiei. sarcoptes scabiei var. hominis is an arthropod member belonging to the order acarina. scabies is present throughout the world and is prevalent in all age groups, mostly involving people frequently in contact with animals, children, women, and elderly people. predisposing factors for scabies include individuals with immunosuppressive conditions and people residing under low socioeconomic conditions. skin lesions that ...201728435762
transcriptome-microrna analysis of sarcoptes scabiei and host immune response.scabies is a parasitic disease, caused by the mite sarcoptes scabiei, and is considered one of the top 50 epidemic diseases and one the most common human skin disease, worldwide. allergic dermatitis, including an intense itch, is a common symptom, however diagnosis is difficult and there is currently no effective vaccine. the goal of this study was to examine the immune interaction mechanism of both s. scabiei and infected hosts. mrna-seq and microrna-seq were conducted on the s. scabiei mite an ...201728542251
systematic review of the diagnosis of scabies in therapeutic trials.human scabies (infestation with the mite sarcoptes scabiei var hominis) causes a significant disease burden worldwide, yet there are no agreed diagnostic guidelines. we aimed to determine whether a consistent approach to diagnosing scabies has been used for published scabies therapeutic trials. the data sources used were the medline, embase and cochrane databases, from 1946 to 29 august 2013. eligible studies were trials of therapeutic interventions against scabies in human subjects, published i ...201728556185
in vitro efficacy of moxidectin versus ivermectin against sarcoptes scabiei.moxidectin is under consideration for development as a treatment for human scabies. as some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for sarcoptes scabieiin vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower than that of ivermectin (0.5 μm versus 1.8 μm at 24 h; p < 0.0001). this finding provides further support for moxidectin as a candidate for the treatment of human scabies.201728559258
proteases of dermatophagoides pteronyssinus.since the discovery that der p 1 is a cysteine protease, the role of proteolytic activity in allergic sensitization has been explored. there are many allergens with proteolytic activity; however, exposure from dust mites is not limited to allergens. in this paper, genomic, transcriptomic and proteomic data on dermatophagoides pteronyssinus (dp) was mined for information regarding the complete degradome of this house dust mite. d. pteronyssinus has more proteases than the closely related acari, d ...201728587273
increase the risk of intellectual disability in children with scabies: a nationwide population-based cohort study.scabies is a common and distressing disease caused by the mite sarcoptes scabiei var. hominis. psychiatric disorder in childhood is an important disease and easily neglected. there are several similarities in scabies and psychiatric disorders in childhood (pdc). both of them may present with pruritus. they are relatively common in patients with lower socioeconomic status and crowded environment. furthermore, immune-mediated inflammatory processes play a role in the pathophysiology in both diseas ...201728591057
gene silencing by rna interference in sarcoptes scabiei: a molecular tool to identify novel therapeutic targets.scabies is one of the most common and widespread parasitic skin infections globally, affecting a large range of mammals including humans, yet the molecular biology of sarcoptes scabiei is astonishingly understudied. research has been hampered primarily due to the difficulty of sampling or culturing these obligatory parasitic mites. a further and major impediment to identify and functionally analyse potential therapeutic targets from the recently emerging molecular databases is the lack of approp ...201728601087
identification of antigenic sarcoptes scabiei proteins for use in a diagnostic test and of non-antigenic proteins that may be immunomodulatory.scabies, caused by the mite, sarcoptes scabiei, infects millions of humans, and many wild and domestic mammals. scabies mites burrow in the lower stratum corneum of the epidermis of the skin and are the source of substances that are antigenic or modulate aspects of the protective response of the host. ordinary scabies is a difficult disease to diagnose.201728604804
evaluation of oxidant/antioxidant balance in iberian ibex (capra pyrenaica) experimentally infested with sarcoptes scabiei.oxidative stress (os) is an imbalance between radical-generating and radical scavenging activity, resulting in oxidation products and tissue damage. although some studies have been done in other species, there is a lack of information about the oxidative/antioxidant status in the iberian ibex (capra pyrenaica) affected by sarcoptic mange. to clarify this fact, albumin, catalase (cat), glutathione peroxidase (gsh-px), superoxide dismutase (sod), paraoxonase-1 (pon-1), glutathione reductase (gr), ...201728606327
sarcoptic mange infestation in rabbits in an organized farm at tamil nadu.sarcoptes scabiei are burrowing mites which causes major constraints in rabbit production. eighty-eight rabbits were examined for mange infestation at university research farm, tamil nadu. overall incidence of mange infestation in rabbit was 23.6 %. on microscopical examination, the mite was identified as sacoptes scabiei var cuniculi. among the breeds, soviet chinchilla were found to be infested more (57.14 %) followed by new zealand white (28.57 %) and white giant (28.57 %). among the age grou ...201728615854
a review of sarcoptes scabiei: past, present and future.the disease scabies is one of the earliest diseases of humans for which the cause was known. it is caused by the mite, sarcoptes scabiei, that burrows in the epidermis of the skin of humans and many other mammals. this mite was previously known as acarus scabiei degeer, 1778 before the genus sarcoptes was established (latreille 1802) and it became s. scabiei. research during the last 40 years has tremendously increased insight into the mite's biology, parasite-host interactions, and the mechanis ...201728633664
genetic characterization of sarcoptes scabiei from black bears (ursus americanus) and other hosts in eastern united states.since the early 1990s there has been an increase in the number of cases and geographic expansion of severe mange in the black bear (ursus americanus) population in pennsylvania. although there are 3 species of mites associated with mange in bears, sarcoptes scabiei has been identified as the etiologic agent in these pennsylvania cases. historically s. scabiei-associated mange in bears has been uncommon and sporadic although it is widespread and relatively common in canid populations. to better u ...201728639466
european guideline for the management of scabies.scabies is caused by sarcoptes scabiei var. hominis. the disease can be sexually transmitted. patients' main complaint is nocturnal itch. disseminated, excoriated, erythematous papules are usually seen on the anterior trunk and limbs. crusted scabies occurs in immunocompromised hosts and may be associated with reduced or absent pruritus. recommended treatments are permethrin 5% cream, oral ivermectin and benzyl benzoate 25% lotion. alternative treatments are malathion 0.5% aqueous lotion, iverme ...201728639722
outbreaks of sarcoptic mange in free-ranging koala populations in victoria and south australia: a case series.to describe outbreaks of sarcoptic mange caused by sarcoptes scabiei in free-ranging koalas in victoria (december 2008 to november 2015) and south australia (october 2011 to september 2014).201728653387
characterization of sarcoptes scabiei tropomyosin and paramyosin: immunoreactive allergens in scabies.scabies is a human skin disease due to the burrowing ectoparasite sarcoptes scabiei var. hominis resulting in intense itching and inflammation and manifesting as a skin allergy. because of insufficient mite material and lack of in vitro propagation system for antigen preparation, scabies is a challenging disease to develop serological diagnostics. for allergen characterization, full-length s. scabiei tropomyosin (sar s 10) was cloned, expressed in pet-15b, and assessed for reactivity with ige an ...201728722633
host immune responses to the itch mite, sarcoptes scabiei, in humans.scabies is a parasitic disease due to infestation of skin by the burrowing mite sarcoptes scabiei. scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. associated bacterial infections cause substantial morbidity, and in severe cases can lead to renal and cardiac diseases. mite infestation of the skin causes localised cutaneous inflammation, pruritus, skin lesions, and allergic and inflammatory responses are mounted by the ...201728797273
sarcoptes scabiei alters follicular dynamics in female iberian ibex through a reduction in body weight.normal development of the ovarian cycle is a key factor in ensuring female reproductive success. sarcoptes scabiei has been shown to induce changes in host physiology, although the effects of this mite on the female reproductive cycle are still unknown. in an attempt to clarify this issue, the number of ovarian structures (primary follicles, secondary follicles, graaf follicles, corpus luteum and corpus albicans) in female iberian ibex (capra pyrenaica) affected by sarcoptic mange was explored b ...201728807285
allergen homologs in the euroglyphus maynei draft genome.euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in humans. it is the source of species-specific allergens as well as allergens that are cross-reactive with the allergens from house dust mites dermatophagoides farinae and d. pteronyssinus, and the ectoparasitic scabies mite sarcoptes scabiei. the genomics, proteomics and molecular biology of e. maynei and its allergens have not been as extensivel ...201728829832
expression and characterisation of a sarcoptes scabiei protein tyrosine kinase as a potential antigen for scabies diagnosis.scabies is a disease that harms humans and other animals that is caused by the itch mite sarcoptes scabiei burrowing into the stratum corneum of the skin. in the early stages of scabies, symptoms are often subclinical and there are no effective diagnostic methods. herein, we cloned, expressed and characterised an s. scabiei protein tyrosine kinase (ssptk) and evaluated its diagnostic value as a recombinant antigen in rabbit during the early stages of sarcoptes infestation. the ssptk protein is ~ ...201728852108
scabies masquerading as bullous pemphigoid: scabies surrepticius.scabies, a parasitic infestation caused by the mite sarcoptes scabiei, is diagnosed by observing either the mite, its ova, or its excrement. the mite tracts, known as burrows and a characteristic presentation of the pruritic condition, are typically found on the web spaces between the fingers. other cutaneous lesions include excoriated papules, pustules, and vesicles. however, atypical clinical variants of scabies, such as bullous, crusted, hidden, incognito, nodular, and scalp forms of the para ...201728883737
is the simple saline mount technique more effective than potassium hydroxide for the microscopic detection of sarcoptes scabiei?not applicable.201728985134
ignoring the "itch": the global health problem of scabies.infestation with sarcoptes scabiei var. hominis is a common human parasitic affliction endemic in tropical developing countries. scabies is transmitted by close person-person contact, and outbreaks have been reported in reception centers for asylum seekers. scabies presents clinically as extremely pruritic excoriated papules and linear burrows in the skin. this infestation predisposes to bacterial skin infections that can result in serious complications affecting the kidneys and possibly the hea ...201729016295
identification of a novel pyp-1 gene in sarcoptes scabiei and its potential as a serodiagnostic candidate by indirect-elisa.scabies is a parasitic disease caused by the ectoparasite sarcoptes scabiei, affecting different mammalian species, including rabbits, worldwide. in the present study, we cloned and expressed a novel inorganic pyrophosphatase, ssc-pyp-1, from s. scabiei var. cuniculi. immunofluorescence staining showed that native ssc-pyp-1 was localized in the tegument around the mouthparts and the entire legs, as well as in the cuticle of the mites. interestingly, obvious staining was also observed on the feca ...201729113603
molecular characteristics and serodiagnostic potential of chitinase-like protein from sarcoptes scabiei.scabies, caused by the mite sarcoptes scabiei, is an allergic skin disease that affects millions of people and other mammals worldwide. this highly contagious parasitic disease is among the top 50 epidemic disease and is regarded as a neglected tropical disease. diagnosis of scabies is difficult in the early stage, and the pathogenesis of scabies is not currently clear. here, we expressed, identified and located the chitinase-like protein of s. scabiei (ssclp), and evaluated its potential as an ...201729137399
sarcoptic mange in wombats-a review and future research directions.sarcoptic mange is caused by the mite sarcoptes scabiei and has recently been recognized as an emerging infectious disease of wildlife worldwide. the mite is one of the main causes of population decline in southern hairy-nosed (lasiorhinus latifrons) and bare-nosed wombats (vombatus ursinus). this review focuses on sarcoptes scabiei infestations in wombats and provides insights into why the disease may be so prevalent in wombats. current treatment practices and trials conducted in the field to r ...201729150905
mitochondrial genome sequencing reveals potential origins of the scabies mite sarcoptes scabiei infesting two iconic australian marsupials.debilitating skin infestations caused by the mite, sarcoptes scabiei, have a profound impact on human and animal health globally. in australia, this impact is evident across different segments of australian society, with a growing recognition that it can contribute to rapid declines of native australian marsupials. cross-host transmission has been suggested to play a significant role in the epidemiology and origin of mite infestations in different species but a chronic lack of genetic resources ...201729183283
crusted scabies due to indiscriminate use of glucocorticoid therapy in infant.crusted or norwegian scabies is a parasitic infectious disease caused by sarcoptes scabiei var. hominis that mainly affects immunocompromised individuals and those with neurological patients. we report a case of crusted scabies in a 4-month-old infant who had been treated erroneously for atopic dermatitis with high doses of corticosteroids. this initial misdiagnosis associated with the abusive use of corticosteroid facilitated the evolution of scabies to crusted scabies and its main complication ...201729186253
scabies in the age of increasing drug resistance.scabies is an infestation of the skin by the mite sarcoptes scabiei. it manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. this paper will review the mechanisms of resistance proposed in the literature and some of the potential solutions to this problem.201729190303
histopathology, microbiology and the inflammatory process associated with sarcoptes scabiei infection in the iberian ibex, capra pyrenaica.sarcoptic mange has been identified as the most significant infectious disease affecting the iberian ibex (capra pyrenaica). despite several studies on the effects of mange on ibex, the pathological and clinical picture derived from sarcoptic mange infestation is still poorly understood. to further knowledge of sarcoptic mange pathology, samples from ibex were evaluated from histological, microbiological and serological perspectives.201729202802
scabies, crusted (norwegian) scabies and the diagnosis of mite sensitisation.scabies is observed with relatively high frequency in allergy and dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. since the immunological response to scabies mites includes the production of ige class antibodies to sarcoptes scabiei allergens which cross-react with dermatophagoides major allergens der p 1 and der p 2, positive immediate-type skin tests to house dust mite ext ...201729279260
 in case of pruritus, always consider scabies! scabies is an itching skin disease caused by the mite sarcoptes scabiei which affects more than 100 million people worldwide. regarded as a neglected tropical disease by the who, it is a major public health burden in endemic areas. as direct skin-to-skin contact is the main route of transmission family members and sexual partners are often affected. typical presentation includes a severely pruritic rash with predilection for the extremities and the t ...201729292916
sarcoptes scabiei on hedgehogs in new zealand.european hedgehogs (erinaceus europaeus) were introduced into new zealand from britain during the period from 1869 to the early 1900s. the only mite found on new zealand hedgehogs in early studies was caparinia tripilis, with sarcoptes scabiei first being reported in 1996. the aim of this study was to investigate the prevalence of sarcoptes infestation on hedgehogs in new zealand, the number of mites found and the degree of mange observed. dead hedgehogs were collected from veterinary clinics, r ...201829318391
a case report of real-time in vivo demonstration of sarcoptes scabiei.scabies is a pruritic dermatosis caused by the ectoparasite sarcoptes scabiei var. hominis. the diagnosis of scabies is usually made on clinical grounds, but histopathological and/or dermoscopic examinations may sometimes be of assistance. however, these diagnostic modalities do not offer a detailed in vivo demonstration of the motile microorganism. reflectance confocal microscopy (rcm) is a relatively novel imaging modality that permits in vivo examination of the skin at a resolution similar to ...201729318996
epizootic of sarcoptic mange in raccoon dogs (nyctereutes procyonoides) in relation to population density.to examine outbreaks of mange in raccoon dogs (nyctereutes procyonoides) with respect to population density, we analyzed camera trap videos, and isolated mites from raccoon dog carcasses. in a camera trapping survey, we categorized the skin condition of raccoon dogs, and used a number of independent videos to calculate the relative abundance index (rai). the rai of raccoon dogs with alopecia increased following an increase in the rai of those without alopecia. among 27 raccoon dog carcasses, 12 ...201829353863
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