Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [necator americanus uncinariasis in an infant born and residing in mexico city]. | a six-month-old infant is reported with the unquestionable diagnosis diagnosis of necator americanus uncinariasis. the mother was also infected with the same hookworm. the patient was born and has always dwelt in mexico city, where helminthiasis is considered extremely rare. the epidemiologic studies determined that the dwelling conditions were inadequate for the transmittal of the agent through the soil. the authors emphasize the importance of the presumptive diagnosis in those cases suggesting ... | 1981 | 7259852 |
| human neonatal infections with hookworms in an endemic area of southern nigeria. a possible transmammary route. | examination of faecal smears of 316 neonates (4-5 weeks old) in a human hookworm endemic area of southern nigeria showed that 33 (10%) of them were hookworm infected. the majority of the neonatal infections (88%) were due to ancylostoma duodenale although necator americanus was the more prevalent hookworm species in the area. the incidence of neonatal infections was pronounced (64%) for mothers who were a. duodenale-positive 5-6 weeks postpartum. a thorough screening of 12.4 litres of colostral ... | 1981 | 7281208 |
| study of the efficacy of compound go.9333 (ciba-geigy) in hookworm infestation. | 50 cases with hookworm infestation were studied to find out the species of the parasite, 25 of them were included for a double-blind trial of compound go.9333 (ciba-geigy)/placebo. results of the study revealed predominance of necator americanus (96%) in and around pondicherry, south india. compound go.9333 was found to very effective in the treatment of hookworm infestation. side effects were minor and were not of much significance. the drug was well accepted and tolerated by most of the cases. ... | 1981 | 7014129 |
| anthelmintic efficacy of amoscanate (c 9333-go/cgp 4540) against various infections in rodents, dogs and monkeys. | the anthelmintic activity of amoscanate (c 9333-go/cgp 4540) has been studied in experimental infections with the human hookworm, necator americanus, in hamsters; nematospiroides dubius, hymenolepsis nana and natural infections with syphacia obvelata in mice; ancylostoma caninum, a. ceylanicum in mongrel dogs; oesophagostomum apiostumum and strongyloides fuelleborni in rhesus monkeys. single oral doses of 30-60 mg/kg eliminated 94 to 99% of the total necator parasites in 37-day-old non-patent in ... | 1981 | 7283017 |
| [epidemiological survey and sanitary problems in a village in east central madagascar]. | an evaluation of health problems is done in a village in eastern madagascar, where takes place a development programme. 217 inhabitants go through physical examination and lab tests are performed (blood smear - thick drop. emmel test. stools examination for parasites and enteroviruses). the epidemiologic investigation reveals the prevalences of malaria (39,4 p. 100) intestinal schistosomiasis (59,9 p. 100) ascaridiasis (61,3 p. 100) hookworm (29,9 p. 100) trichuriasis (19,8 p. 100) and sickle ce ... | 1981 | 7200761 |
| wormy persons: contributions to the nature and patterns of overdispersion with ascaris lumbricoides, ancylosotma duodenale, necator americanus and trichuris trichiura. | the dominant intestinal helminths in the iranian villages of kargar malleh (hookworms), bandar abbas (hookworms) and jazin (ascaris lumbricoides and trichuris trichiura), were recorded with their frequency distributions, in 80, 40 and 111 villagers, respectively in 1977-78. anthelminthics were then used to remove all intestinal stages which were identified and counted. analyses showed clumped or over-dispersed patterns in all cases. each community contained 'wormy persons', 1 to 3% of the indivi ... | 1981 | 7314236 |
| transient hypereosinophilia in necator americanus and schistosoma mansoni infections. | 1981 | 7330957 | |
| [albendazole. evaluation of tolerance and efficacy in oxyuriasis, trichocephaliasis, ankylostomiasis, ascaridiasis, anguilluliasis]. | albendazole was given to some men for the first time. 131 patients (43 children) received different dosages, without clinical intolerance. biological parameters were normal. each study was made in two parts: - determination of the good dosage, - administration in a double-blind study (except for strongyloides stercoralis). albendazole has a good efficiency against enterobius vermicularis, trichuris trichiura, ascaris lumbricoides and necator americanus. strongyloides stercoralis seems to be kill ... | 1981 | 7028298 |
| [evaluation of the main intestinal parasitosis in 860 ivory coast children from thirteen different villages (author's transl)]. | a survey has been carried out in 2 forest villages, 9 savanna villages and 2 abidjan suburb districts. a total sample of 860 children aged between 6 and 15, has been examined. data tabulation indicated a prevalence of the main intestinal nematodes, of s. mansoni and of e. histolytica, with variable respective percentage. ascaris lumbricoides affected 26 p. 100 of children but is less frequent in the savanna areas than in the forest areas. trichiuris trichiura affected 1 child out of 4 but infest ... | 1981 | 6264268 |
| the anthelmintic effects of mebendazole on necator americanus in rabbit model. | 1982 | 7166638 | |
| [an epidemiological study of intestinal bilharziasis and roundworm infections in bafia (cameroon)]. | the prevalence of intestinal helminthiasis is measured by means of stool examinations. in bafia eggs are passed in the feces of 69.1% of the inhabitants for ascaris lumbricoides, 70.1 % for trichuris trichiura, 59.6 % for necator americanus and 14.8% for enterobius vermicularis. a small focus of intestinal bilharziasis exists in bafia and eggs of schistosoma mansoni are found in the feces of 18.6% of the persons studied. biomphalaria pfeifferi is the intermediate host of the parasite and transmi ... | 1982 | 7105280 |
| skin penetration by necator americanus larvae. | skin penetration by necator americanus larvae has been investigated in vitro. larvae were able to penetrate completely human skin from both the epidermal and dermal directions; their passage through the epidermis was marked by cellular destruction. removal of chloroform soluble skin lipids affected both the percentage of larvae invading and the percentage exsheathing. the larvae released an enzyme at about 37 degrees c, which showed peak activity against azocoll at 37 degrees c and ph 8. it is s ... | 1982 | 7136195 |
| changes in carbohydrate metabolism in golden hamsters infected with necator americanus. | 1982 | 7149838 | |
| albendazole: a new broad spectrum anthelmintic. double-blind multicenter clinical trial. | a new anthelmintic drug, albendazole, has been tested in a multicenter double-blind placebo controlled study in 392 patients from france and west africa in children and adults with single or mixed infections caused by roundworms, hookworms, whipworms, threadworms and tapeworms. all patients were closely observed before and after treatment for clinical side effects, hematological or clinical blood chemical changes. fecal samples obtained before, and 7 days and 21 days after treatment were examine ... | 1982 | 7041665 |
| canine biliary carcinoma: epidemiological comparisons with man. | a retrospective study of abstracted data representing 1.1 million hospital examinations of dogs at veterinary university teaching facilities identified 77 with bile duct carcinoma. using the hospital population, based on patient years at risk, as the expected frequency of particular zoographic characteristics, there was a suggestion of a familial (breed) predisposition in labrador retrievers and limited evidence of a sex differential. because mongrel dogs displayed about the same frequency of bi ... | 1983 | 6841697 |
| average values of ancylostoma duodenale and necator americanus cholinesterase activity in humans. | 1983 | 6403314 | |
| necator americanus infection: a longitudinal study of an urban area in nigeria. | a longitudinal study was carried out in owerri, capital of imo state, nigeria, to assess the pattern of necator americanus infection during a 27-month period. the mean annual prevalence fell from 59.0% in 1978, to 55.5% in 1979 and 51.1% in 1980. the egg count (apparent intensity of infection) fell in a similar pattern. maximum and minimum conversion rates were 55.2 and 13.7%, respectively, and conversion rates fell by approximately 20% between 1979 and 1980. the highest reversion rate was 55.0% ... | 1983 | 6625730 |
| endoscopic discovery and capture of necator americanus in the stomach. | we report a case of the endoscopic discovery and removal of a specimen of necator americanus hooked into the gastric mucosa of a black woman from zaire. we extracted the parasite by means of biopsy forceps. signs of previous bites were seen in the antrum. this exceptional localization might be due to a jejuno-duodeno-gastric reflux. | 1983 | 6851955 |
| albendazole: placebo-controlled study in 870 patients with intestinal helminthiasis. | a total of 870 patients, both males and females, from 3 to 79 years old, received either albendazole or a placebo for the treatment of nematode and cestode infections. each patient was interviewed and underwent a complete physical examination on the initial visit. in addition, complete blood count, clinical blood chemistry values and routine urinalysis were performed before and at least 24 hours after the last treatment. stool examinations were performed before, 7 and 21 days after treatment. di ... | 1983 | 6362125 |
| the distribution of necator americanus and ancylostoma duodenale in school populations, gojam and gondar administrative regions. | 1984 | 6723632 | |
| larvicidal activity of albendazole against necator americanus in human volunteers. | this study evaluated the efficacy and tolerance of a single oral 400-mg dose of albendazole on necator americanus larvae, and compared its efficacy when administered between meals or with a meal. twenty-nine healthy and hookworm-free male volunteers were exposed on the forearm to approximately 45 8-day-old n. americanus larvae. all subjects developed discrete maculopapular eruptions at the site of larval application. following a random double-blind study design, each subject received at the end ... | 1984 | 6731670 |
| [comparative value of egg size and larval morphology in the diagnosis of species of ancylostomids. existence of abnormal larvae]. | the values of eggs mensuration and results of coproculture have been compared for the identification of species of ancylostomia infestations. results are confirming the necessity of coproculture for this diagnosis when the size of eggs is not inferior to 61 mu or superior to 72 mu. one case of morphological anomaly of some strongyloïd larvae of necator americanus has been related. | 1984 | 6541285 |
| human intestinal parasitism in three areas of indonesia: a survey. | stools from 1387 people were examined quantitatively for eggs of nematode parasites. the people were residents of padangganting, near sawahlunto, sumatra (227 people), sukamaju and cibungur rubber plantations near sukabumi, java (831 people) and the villages of mahima and rabo near reo, manggarai, flores (329 people). ascaris lumbricoides, trichuris trichiura and necator americanus were common; ancylostoma was not observed. prevalence of parasitism was highest in java and lowest in flores. egg c ... | 1984 | 6543421 |
| [geographic distribution of ancylostoma duodenale and necator americanus in taiwan]. | in order to determine the geographical distribution of ancylostoma duodenale and necator americanus in taiwan, 2,759 fresh stool samples were collected from 5th-grade school children of both sexes among 43 preliminary schools in 16 counties, and then examined by means of the modified test-tube filter-paper cultivation method for identification of the filariform larvae of hookworm. both species of a. duodenale and n. americanus are widespread in taiwan. the overall infection rate was 20.00%. the ... | 1984 | 6510063 |
| reinfection with intestinal helminths after treatment with mebendazole and fluctuations in individual ascaris lumbricoides infections with time. | in a group of rural school children in the highlands of papua new guinea with an initial prevalence of ascaris lumbricoides 71 per cent, trichuris trichiura 69 per cent and necator americanus (hookworm) 95 per cent, 2 1/2 months after treatment with mebendazole the prevalence of a. lumbricoides and t. trichiura was very low, that of n. americanus was about 20 per cent and all egg counts were very low. prevalence rates and egg counts of a. lumbricoides returned to pretreatment levels 9 months aft ... | 1984 | 6598553 |
| changes in lipid contents of infective third-stage larvae of necator americanus during desiccation and revival. | changes in lipid content of infective third-stage larvae of necator americanus were investigated after short periods of induced desiccation and revival. a fall in lipid reserve from an outset level of 86% to 74% was recorded in the first 2 h of desiccation. with increased desiccation, lipid reserves did not show significant decline, probably as a result of decreased lipid metabolism in the desiccated larvae. during revival, there was a drastic fall in lipid reserves as a result of increased lipi ... | 1984 | 6695536 |
| necator americanus infection: a cross-sectional study of a rural community in relation to some clinical symptoms. | 1984 | 6332584 | |
| a survey of gastrointestinal parasites in a local government area of south-west nigeria. | in the course of a survey of gastro-intestinal parasites among humans in iwo local government area in south-western nigeria, eggs of helminths found were those of ascaris lumbricoides, necator americanus, trichuria trichiura and strongyloides stercoralis while protozoan cysts encountered were those of entamoeba histolytica and entamoeba coli. about 51% of the 283 faecal samples were positive for parasitic ova or cysts and 24% possessed mixed infection. incidence of ascaris was highest followed b ... | 1984 | 6094377 |
| albendazole: a new single dose anthelmintic. study in 1455 patients. | albendazole has been tested in an open trial conducted in france, seven countries of west-africa, martinique and the people's republic of china in a total of 1455 patients harboring single or mixed infections caused by round-worms, pinworms, hookworms and whipworms. all patients were closely observed before and after treatment for clinical side effects and hematology and clinical chemistry values were done in about 5% of the cases. fecal samples obtained before and approximately 15, 16 and 17 da ... | 1984 | 6143488 |
| studies on the co-occurrence of two species of human hookworm in a riverine community in nigeria. | a total of 1,623 stool specimens from different individuals were examined to assess the infection prevalence and the pattern of occurrence of necator americanus and ancylostoma duodenale in a riverine community in nigeria. 56.3% of 823 males and 52.63% of 800 females were positive for both species of hookworm, 25.1% of infected males, and 26.1% of infected females had a. duodenale while 46.7% of infected males and 51.2% of infected females had n. americanus. 28.2% of males and 22.7% of females h ... | 1984 | 6710599 |
| hookworms and the species infecting man in zambia. | the rate of hookworm infections, determined by stool examination over a 7-month period, was 16.56% in medical examinees and 19.91% in in-patients in an urban hospital population in zambia. the egg-load though was low. culture of ova to the filariform larval stage, examination of adult worms expelled after anthelminthic treatment and collected at autopsy confirmed that the dominant species was necator americanus. however, we report, perhaps for the first time, the presence of ancylostoma duodenal ... | 1984 | 6716541 |
| [ancylostomiasis in congo children among the population of brazzaville]. | the prevalence of hookworm infection was measured by means of stool examinations including direct examination and the willis technique in 230 children between the ages of 2-14 years living in brazzaville, people's republic of the congo. 120 of them were seen in a hospital. the overall prevalence was 24.3%. the prevalence increased with age until 6-8 years. a highest prevalence was found in male and, whatever the sex, in children in hospital for digestive disorders, anemia-malnutrition and also f ... | 1984 | 6488422 |
| ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis. | albendazole, a broad spectrum anthelmintic, was administered as a 400 mg single dose to 20 patients harbouring ascaris (ten cases), hookworms (four cases each of ancylostoma duodenale and necator americanus) and trichuriasis (ten cases). faeces were obtained before treatment and during the following five days. coprocultures were made for 90 days for ascaris and trichuris eggs, hookworm eggs were cultured by the harada-mori technique for at least eight days. albendazole was ovicidal against all f ... | 1985 | 4039128 |
| necator americanus and ancylostoma ceylanicum: development of protocols for dual infection in hamsters. | two-day-old baby hamsters were infected initially with the infective larvae of hamster-adapted human hookworm, necator americanus (nal3). after a specified period they were again infected orally with infective larvae of ancylostoma ceylanicum (acl3). three weeks after the second infection they were killed and the establishment of n. americanus and a. ceylanicum was assessed. the effect of different infection levels and exposure period of n. americanus on the concurrent establishment of a. ceylan ... | 1985 | 2859749 |
| site of resistance to necator americanus in hamsters. | resistance to the development of human hookworm, necator americanus was examined in 3- to 6-week-old young adult hamsters. only 3% of n. americanus infective third stage larvae (nal3) reached maturity in the intestines of young adults as opposed to as many as 60% in 2-day-old baby hamsters. this seemingly effective resistance prevailing in young adults was investigated in some detail. the skin, the first site of contact for the invading nal3, was bypassed during the infection process. completely ... | 1985 | 2868635 |
| hookworm burdens and faecal egg counts: an analysis of the biological basis of variation. | the relationships between various measures of faecal egg output and hookworm burdens were investigated in 84 villagers from west bengal with mixed necator americanus and ancylostoma duodenale infections. the pattern of day to day variability in egg counts from individuals can be characterized by the linear relationship between the logarithms of the variances and means. egg output is shown to be non-periodic in long runs of day-to-day records. the distribution of worm numbers per host is well des ... | 1985 | 3832493 |
| necator americanus and ancylostoma duodenale in dhaka city. | 1985 | 3837662 | |
| a study of the effectiveness of mebendazole and pyrantel pamoate as a combination anthelmintic in papua new guinean children. | a mixture of 150 mg mebendazole and 30mg pyrantel pamoate was given on 3 consecutive or near-consecutive days to 70 children infected with one or more of necator americanus, ascaris lumbricoides, strongyloides stercoralis, s. fuelleborni-like and trichuris trichiura. this treatment had an efficacy of 95 per cent for n. americanus infections, 100 per cent for a. lumbricoides, 57 per cent for strongyloides spp., and 75 per cent for t. trichiura. the results indicate that the treatment given is eff ... | 1985 | 3862315 |
| distribution of ancylostoma duodenale and necator americanus in ethiopia. | 1985 | 3876932 | |
| hookworm infection in kweneng district, botswana, a prevalence survey and a controlled treatment trial. | stool specimens from a sample of schoolchildren at six schools in kweneng district were examined for hookworm infection, using the brine flotation method. necator americanus was the only hookworm identified. the western part of the district forms part of the kalahari desert, and in four villages here 90%, 88%, 88% and 86% of the children were infected. in two villages in the eastern non-desert part, only 13% and 9% were infected. most infections were light. there was no significant correlation b ... | 1985 | 3914119 |
| survey for soil-transmitted helminths in asahan regency, north sumatra, indonesia. | the survey on soil-transmitted helminthiasis was carried out in the three villages of asahan regency, north sumatra, indonesia, between october 1981 and december 1982. the prevalence rates of geohelminthiasis proved to be extremely high (average 97%) in the three villages and more than 70% harboured three or more helminths, especially ascaris lumbricoides, trichuris trichiura and hookworm. necator americanus and ancylostoma duodenale were detected in 61.1% and 52.2% of 835 fecal specimens, respe ... | 1985 | 4095609 |
| ancylostoma duodenale and necator americanus in the abay (blue nile) gorge. | 1985 | 4006926 | |
| [studies on the cultivation of the adult necator americanus in vitro]. | 1985 | 4006115 | |
| selective primary health care: strategies for control of disease in the developing world. xvii. hookworm infection and anemia. | approximately one-quarter of the world's population is infected with either ancylostoma duodenale or necator americanus. humans transmit the hookworm by fecal contamination of the soil. the eggs hatch and the larvae may survive several months in warm, damp soil. humans are infected when the larvae penetrate the skin and migrate through the body to the intestines, where the median survival time of the hookworm is one year. the loss of red blood cells into the gut is proportional to the worm load. ... | 1985 | 3983524 |
| [new guinea and australia: their common pathology]. | new guinea and australia have been joined together during several hundred millions of years. inhabited by men 40,000 years ago, these populations (papous and aborigenes) have been separated of the others during several millenaries. the first invaders brought with them plasmodiums, necator americanus, wuchereria bancrofti and dengue virus. brugia malayi, because lack of primates, took non root in new guinea; the virus of murray valley encephalitis is autochthonous; the high frequency of burkitt l ... | 1985 | 4085103 |
| [distribution of necator americanus and ancylostoma duodenale in santa cruz, bolivia]. | 1985 | 4037896 | |
| sodium azide preservation of faecal specimens for kato analysis. | the modified kato technique has the advantages of reproducibility, simplicity and economy: the disadvantage is that it cannot be used in conjunction with traditional faecal preservatives. sodium azide has been evaluated as a preservative for human faeces for subsequent kato analysis. more than 400 faecal samples (from normal and malnourished children, and from mixed-age participants in a field survey of the turks and caicos islands) were each mixed with 2-5 mg of sodium azide powder and stored i ... | 1985 | 4011316 |
| [hypotheses on the origin of certain parasites on the latin american continent]. | the south american continent has been connected to africa over millions of centuries. in prehistorical time, the filling of the bering strait allowed passage on firm ground between asia and north america. south american peopling has thus occurred from north america, through the pacific sea and, from the 15th century a.c., through the atlantic. necator americanus was present in south america prior to the arrival of black slaves and its african origin is probably related to contacts between africa ... | 1985 | 3928184 |
| response of preadult necator americanus to some known anthelmintics in hamsters. | hamsters infected with laboratory-adapted preadult necator americanus were dosed with 6 reference anthelmintics. their efficacy was measured in terms of percentage cure of infected animals as well as percentage worm reduction following treatment. mebendazole and pyrantel were equally effective in this system. other anthelmintics, including anti-hookworm compound, bephenium hydroxynaphthoate, were less effective. the comparative results revealed that the n. americanus model is sensitive and relia ... | 1986 | 3948582 |
| response of laboratory-adapted human hookworm and other nematodes to ivermectin. | the activity of ivermectin was examined in necator americanus, a human hookworm, adapted to the laboratory hamster. a dose of 30 mg kg-1 x 1 or 10 mg kg-1 x 2 was required for complete clearance of pre-adult n. americanus; however, hamsters carrying adult n. americanus were completely cured of infection by doses of 15 mg kg-1 or 7.5 mg kg-1 x 2. the doses of ivermectin required for complete elimination of n. americanus were much higher than those reported for other intestinal nematodes. the prob ... | 1986 | 3675034 |
| the growth and migration of necator americanus following infection of neonatal hamsters. | necator americanus was studied in neonatally infected hamsters in order to determine precisely the growth and migration of the parasite in this laboratory host. most larvae stayed at the skin infection site for at least 48 hours following administration of larvae and the movement to the lungs commenced on day 3. there was no significant growth at the skin site or during the first two days in the lungs. 98% of the larvae were recovered from the lungs by day 6 and showed signs of some growth and d ... | 1986 | 3726976 |
| an improved technique for experimental infections with skin penetrating nematode larvae (necator americanus). | 1986 | 3781729 | |
| changes in the structural and functional properties of human eosinophils during experimental hookworm infection. | normal volunteers were infected with hookworm larvae necator americanus. peripheral blood counts showed a mean of 524 +/- 29 eosinophils/mm3 of blood before infection and a mean of 3,008 +/- 456 eosinophils/mm3 of blood during infection (p less than .01). absolute numbers of neutrophils did not change. eosinophils and neutrophils from the infected period were compared with the noninfected state in each subject. the percentage of hypodense eosinophils increased from a mean of 34% +/- 13% to 80% + ... | 1986 | 3021866 |
| identification of hookworm (necator americanus) antigens and their translation in vitro. | during in vitro culture adult (day 35) necator americanus synthesise a wide range of protein species many of which are excreted or secreted into the culture medium. both post infection (day 117) hamster sera and sera from infected humans precipitate antigens of 15, 30, 33, 44, 46 and 69 kda although individual human sera exhibit some variability in absolute specificity. in immunoblotting experiments antigens of 33 kda are routinely recognised by human sera although two-dimensional gel analysis s ... | 1986 | 2426588 |
| the recognition of antigens on the surface of adult and l4 necator americanus by human and hamster post-infection sera. | the surface antigens of adult necator americanus were recognized by post-infection hamster sera and resolved at molecular weight 93,000, 67,000, 46,000, 43,000, 32,000 and 25,000. l4 larvae in contrast had one major surface antigen, resolving at 93,000. these antigens were also recognized by a range of human sera, although on a differential basis. this suggests that the human sera tion. however, the results do indicate that the hamster model might be of immunological relevance to the human disea ... | 1986 | 2427992 |
| antigen expression during development of the human hookworm, necator americanus (nematoda). | the accumulated and de novo synthesized antigens expressed by l3, l4 and adult necator americanus, recognized by both the natural host, man, and the experimental host, the hamster, were identified by immunoblotting and immunoprecipitation analysis. following infection of neonatal hamsters serum samples were taken on days 17, 35 and 117. only serum taken 117 days after infection showed significant reactivity in immunoblotting experiments, recognizing adult epitopes of 30,000, 33,000, 48,000 and 6 ... | 1987 | 2437516 |
| human hookworm necator americanus in the intestines of young adult hamsters. | 1987 | 3437359 | |
| the response of adult and free-living stages of necator americanus, in vitro, to anthelmintics. | the in vitro response of adults (males and females) and free-living stages of necator americanus one of the human hookworms, to a wide variety of 20 broad and narrow spectrum anthelmintics was tested. almost all the broad spectrum anthelmintics influenced males, females and free-living stages at different levels and showed good activity with ec50 values varying from about 0.0002 and 0.0007 mg/l for pyrantel pamoate and tricofenol piperazine respectively to about 8.47 and 7.6 mg/l for morantel ta ... | 1987 | 3444926 |
| hookworm (necator americanus) and strongyloides fuelleborni-like prevalence and egg count with age in highlands fringe people of papua new guinea. | 1987 | 3475865 | |
| necator americanus in neonatally infected hamsters. the time-course of infection and antibody response to the surface antigens of l4 and adult worms. | neonatal hamsters were infected with a hamster-adapted strain of necator americanus, and the time-course of infection was followed by worm and faecal egg counts. parasite eggs were first recorded during the 6th week of infection, increasing rapidly thereafter to peak in weeks 7-10. male hamsters excreted more eggs than females, but both sexes were equally susceptible to infection and harboured comparable worm burdens. faecal egg counts declined from week 10 onwards and this was associated with a ... | 1987 | 3503418 |
| hookworm infection in a rural community in south india and its association with haemoglobin levels. | faecal samples were obtained from 1113 persons living in a rural area in south india, and the hookworm ova load (necator americanus) was determined using kato's thick smear method. evidence of hookworm infection was present in 92%, 77% having a count of under 100 epg, 11% a count of 1000 to 1999 epg, and 4% having counts between 2000 and 12,000 epg. females had significantly higher ova counts than males on the average, but age did not appear to have any effect. haemoglobin was also estimated: 80 ... | 1987 | 3503419 |
| necator americanus: temperature, ph, light, and larval development, longevity, and desiccation tolerance. | the effect of incubation temperature and ph on the hatch rate of eggs of necator americanus, and the desiccation tolerance of the resulting infective stage-3 larvae were investigated in the laboratory under controlled conditions. hatching did not occur below 15 c and above 35 c. a 21% hatch rate was obtained at 15 c while a 10.6% hatch rate was obtained at 35 c. the highest hatch rate (93.7%) was obtained at 30 c. the optimum ph for hatching was 6.0, but the larvae did not reach the infective st ... | 1987 | 3569472 |
| the clinical and immunologic responses of normal human volunteers to low dose hookworm (necator americanus) infection. | five normal human volunteers were exposed to approximately 50 infective larvae of necator americanus and were observed for the development of clinical signs or symptoms and for changes in blood eosinophil levels, igg antibody titers, total and parasite-specific ige, and lymphocyte blastogenic responses for 6-10 weeks. bronchoalveolar lavage was performed on four subjects prior to infection and at times when larval migration through the pulmonary tree was likely. eggs were demonstrated in the sto ... | 1987 | 3605493 |
| [effects of various anti-hookworm drugs on the cholinesterase activity of necator americanus, ancylostoma duodenale, ancylostoma caninum and nippostrongylus braziliensis]. | 1987 | 3621504 | |
| differential efficacy of mebendazole and albendazole against necator americanus but not for trichuris trichiura infestations. | the effect of single oral doses of albendazole 600 mg and mebendazole 1 g given to 56 and 60 men, respectively, with t. trichiura and/or n. americanus infestation has been studied. both albendazole and mebendazole cured more than 90% of t. trichiura infestations, but only albendazole (95%) and not mebendazole (21%) had a high cure rate for n. americanus infestations. thus, albendazole is the preferred benzimidazole derivate for the mass treatment of subjects with t. trichiura and/or n. americanu ... | 1987 | 3653234 |
| adherence of human eosinophils to infective filariform larvae of necator americanus in vitro. | eosinophilia is common in hookworm infection but the interaction between eosinophils and the larval stage of the parasite is poorly understood. the present study was conducted to test the ability of the eosinophils to adhere to infective filariform larvae of necator americanus in vitro. adherence of eosinophils to the larvae was found to be serum dependent. antibody facilitated eosinophil adherence but this was maximal in the presence of complement. the adherence was greatly diminished by egta t ... | 1987 | 3660070 |
| comparative study of different doses of mebendazole in hookworm infection. | sixty six children (40 males, 26 females) aged from 4 to 14 years with hookworm infection were treated with mebendazole. thirty one and 35 children were treated with mebendazole 300 mg single dose and 600 mg conventional regimen respectively. stool examination by kato-katz technique were done for 3 consecutive days before treatment and on day 14-16, 21-23 after treatment. the cure rate with 300 mg mebendazole was 16.1% with 90.9% egg reduction while 600 mg mebendazole gave 91.4% cure rate with 9 ... | 1987 | 3672183 |
| hookworm antigens: the potential for vaccination. | hookworms rank with ascaris as the most prevalent soil-transmitted helminths of man. up to 1000 million people may be infected. not all suffer the life-threatening anaemia that reflects heavy burdens of hookworms, but even mild iron-deficiency anaemia due to hookworms can lead to intellectual and growth retardation - especially among infected children. health education, mass chemotherapy and the sanitary disposal of faeces have been the traditional mainstays of hookworm control, but more recentl ... | 1987 | 15462967 |
| do hookworms elicit protective immunity in man? | the two main species of human hookworm, ancylostoma duodenale and necator americanus (table 1), are together believed to infect about 900 million people - mainly in tropical countries where adequate sanitary facilities may be lacking. but interactions between the two species, and their relative contributions to observed age-related infection patterns and seasonal cycles of transmission, continue to engender controversy. people tend to remain susceptible to infection through-out life, even with c ... | 1987 | 15462956 |
| acquired resistance to the human hookworm necator americanus in mice. | balb/c mice were exposed to primary or secondary infection with the hamster-adapted strain of necator americanus, and the course of infection was monitored through worm recovery and immunological assays. significantly fewer viable larvae were recovered from the skin site of reinfected mice on day 2 post-infection, and fewer larvae resided in the lungs of challenged mice 3-5 days after infection, suggesting that the skin was involved in resistance to secondary infection. the serum antibody respon ... | 1988 | 3194147 |
| [histological and histochemical effects of tribendimidine on necator americanus]. | 1988 | 3213546 | |
| experimental and field studies on the viability of eggs, and the infectivity of third-stage larvae of the human hookworm necator americanus recovered from the creek waters of the niger delta, nigeria, and their epidemiological significance. | in a combined field and laboratory study, the eggs and 3rd-stage infective larvae of the human hookworm necator americanus were recovered from the creek waters of the niger delta, nigeria. they were tested for viability and infectivity. eggs recovered from fresh water creeks showed a viability or hatching index of between 17.5 and 23.7%. eggs recovered from brackish water showed a viability index of 18.8-21.4% in 'normal' cultures, and a maximum index of 6.3% when cultured in brackish water. the ... | 1988 | 3362571 |
| the course of primary infection with necator americanus in syngeneic mice. | 1988 | 3366536 | |
| cuticle preparations from necator americanus and their immunogenicity in the infected host. | cuticle samples have been prepared from the human parasitic nematode necator americanus using detergent solubilisation with sodium dodecyl sulphate and subsequent reduction of disulphide bonds using 2-beta-mercaptoethanol. it would appear that n. americanus, like many other nematodes, relies on relatively small collagenous proteins, linked by disulphide bonds, to maintain the integrity of its cuticle. these molecules are normally hidden from the immune system during the course of infection but a ... | 1988 | 3386684 |
| an investigation of hookworm infection and reinfection following mass anthelmintic treatment in the south indian fishing community of vairavankuppam. | hookworm infections, as assessed by counting worms expelled following anthelmintic treatment and by egg output, were found to be of low prevalence and intensity in a south indian fishing community. the initial overall prevalence of infection in the community was 43%, and the average burden was estimated at 2.2 hookworms per person. the age profiles of prevalence and intensity differed between males and females, with the latter harbouring significantly higher levels of infection. children of both ... | 1988 | 3405641 |
| simultaneous isolation of hiv-1 and hiv-2 from an aids patient. | two distinct human immunodeficiency viruses, hiv-1sf480 and hiv-2uc2 were isolated simultaneously from the blood of an ivory coast patient with aids. the hiv subtypes were segregated by their differential ability to infect established human cell lines and by the cell surface expression of type-specific viral antigens. the viruses could be distinguished by both immunoblot and southern blot analyses. the results indicate that an individual can be infected by both hiv subtypes. | 1988 | 2904524 |
| the role of some cyclorrhaphan flies as carriers of human helminths in malaysia. | the role of some adult flies (diptera: cyclorrhapha) as carriers of helminth parasites of man was studied at four sites in malaysia: a refuse dump, where no helminth-positive flies were detected, and in three peri-domestic situations where four species of flies carried up to three types of nematodes. the dominant fly species chrysomya megacephala (fabricius) carried eggs of the roundworm ascaris lumbricoides l., the pinworm trichuris trichiura (l.) and hookworm on the adult external body surface ... | 1988 | 2980156 |
| ivermectin for human strongyloidiasis and other intestinal helminths. | since ivermectin, a mixture of 2 closely related macrocyclic lactones, has proven highly effective against animal intestinal nematodes, trials were undertaken to determine its efficacy against human intestinal nematodes. we tested 110 patients with strongyloidiasis and 90 with enterobiasis; many had other intercurrent intestinal nematode infections. stool examinations were done before and after patients were given a single dose of oral ivermectin capsules (50, 100, 150, or 200 micrograms/kg body ... | 1989 | 2929853 |
| [ancylostomiasis]. | ancylostomiasis, i.e., infestation by ancylostoma duodenale or necator americanus, involves several thousands of subjects every year throughout the world and especially in tropical and subtropical regions where it is endemic. in italy, after a severe epidemic during the construction of the st. gotthard tunnel in the 1880s, and after a period of endemic infestation limited to some areas (1955-60), the last few years have witnessed a marked drop in the incidence of this disease which is neverthele ... | 1989 | 2529085 |
| entamoeba histolytica and other parasitic infections in south kanara district, karnataka. | single stool specimens collected from 1,020 apparently healthy people of the south kanara district, were processed for intestinal parasites using three parasitological methods viz. (a) direct smear in physiological saline and d'antoni's iodine, (b) zinc sulfate concentration method and (c) by culture in modified boek and drbolhav medium. of these 781 (76.51 per cent) were found to be infected with parasites. the prevalence of various intestinal parasites was: ascaris lumbricoides (48.33 per cent ... | 1989 | 2559118 |
| [chronic diarrhea and parasitoses in adults suspected of aids in the ivory coast]. | 148 adult patients with chronic diarrhoea and suspected to be hiv infected have had stool examinations. 46 are without any enteric parasite. those detected in the others patients are sporozoans: i. belli (16.2%) and cryptosporidium sp. (6.7%) found alone or joint, together or with other parasites. among those, all flagellate species are identified, but t. intestinalis (6%) is predominant. entamoeba coli (8.%) is the most frequent amebic species, however, e. histolytica histolytica have been foun ... | 1989 | 2561272 |
| a study of the efficacy and safety of albendazole (zentel) in the treatment of intestinal helmenthiasis in kenyan children less than 2 years of age. | one hundred children comprising of 57 males and 43 females aged between 8 and 24 months entered the study. 46 children had single and 54 children had multiple helminth infections. all children received albendazole 200 mg (10 ml) suspension as a single dose. albendazole proved very effective and safe in the treatment of single and multiple helminth infections in children under 2 years of age, achieving cure rates of 100% in both ascaris lumbricoides and necator americanus respectively, 83% in tri ... | 1989 | 2591328 |
| response of adult necator americanus to some known anthelminthics in hamsters. | adult necator americanus infection in laboratory hamsters (the hamster-hookworm model) was examined as an anthelminthic screening system. three reference anthelminthics--pyrantel (pytl), mebendazole (mbz) and ivermectin (ivrn)--were used to assess the sensitivity of adult n. americanus and also to investigate the value of the hamster-hookworm model for predicting clinical results. serial drug dosages were used, and the ed50 was determined from the resulting cure rates. in addition, percentage wo ... | 1989 | 2604466 |
| strongyloides cf fuelleborni in papua new guinea: epidemiology in an isolated community, and results of an intervention study. | strongyloides cf fuelleborni was found to be distributed homogeneously with respect to space and time in a semi-nomadic community in papua new guinean rainforest. the parasite predominantly infects children, reaching 60% prevalence in the first year of life and peaking around 80% at five years of age. egg loads follow a similar pattern but peak earlier (at 20 months) and fall off more sharply. the few infected adults have very light infections as measured by egg count. in the first few months of ... | 1989 | 2619364 |
| coproantigens in gut tapeworm infections: hymenolepis diminuta in rats. | a capture enzyme-linked immunosorbent assay (elisa) for the detection of hymenolepis diminuta coproantigen in detergent-solubilised faecal supernatants was developed. the assay was sensitive to 400 ng h. diminuta protein/ml faecal supernatant and to 30 ng/ml in pbs 0.3% tween. faecal antigen levels started to rise on day 7 post infection and peaked on day 20. following drug treatment of infected rats with 10 mg/kg praziquantel, there was an initial steep rise in faecal antigen levels, followed b ... | 1989 | 2622898 |
| albendazole in the treatment of goehelminth infections in children. | children with mixed helminthic infections between the ages of 2 and 14 years, from a slum area, were treated with two regimes of albendazole. a majority of children had moderate to heavy infections with trichuris trichiura (greater than 70%) and ascaris lumbricoides (greater than 84%). children treated with a single 400 mg dose of albendazole showed a very good response in ascariasis with 100% cure rate irrespective of the severity of infection. in trichuriasis (n = 40), a cure rate of 50% was o ... | 1989 | 2627728 |
| filarial parasites exhibit unusually high levels of choline acetyltransferase activity. | the presence of unusually high levels of choline acetyltransferase (chat, ec 2.3.1.6) in human and animal filarial parasites has been demonstrated. the levels of chat were highest in male worms of brugia malayi and brugia pahangi, with specific activities in crude extracts of about 2.27 and 1.26 mumol min-1 (mg protein)-1, respectively. the enzyme levels in these worms were over 10-20 times higher than in male worms of litomosoides carinii. the chat levels were about 2-5 times higher in male tha ... | 1989 | 2664508 |
| the action of a mast cell protease on the cuticular collagens of necator americanus. | collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult necator americanus and shown to be susceptible to digestion by purified mast cell proteases. although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important under ... | 1989 | 2671869 |
| effect of single-dose albendazole and single-dose mebendazole on necator americanus. | one hundred two children (43 males and 59 females) aged 6 to 14 years with positive stool examination by kato-katz and/or harada-mori culture techniques for n. americanus, were randomly divided into two groups. group i with 48 children were treated with a single dose albendazole, 400 mg. group ii, 54 children, received a single dose mebendazole, 600 mg. after treatment, repeated stool examination was performed on day 14, day 21 and day 28. the children were considered cured when stool examinatio ... | 1989 | 2692189 |
| [single dose mebendazole for the treatment of trichuris trichiura and necator americanus in chemotherapeutic control campaigns in the communities]. | a study of intestinal parasitism is made in "argelia libre" community, isle of youth, by means of four coproparasitologic techniques: kato kratz, ritchie, direct, and willis. patients with geohelminths are divided into two groups of treatment: group a, treated with 500 mg mebendazole in single doses and group b, treated with the classical scheme of 100 mg every 12 hours for three days. results of treatment are expressed in terms of cure rates and percentage of egg-count reduction. when comparing ... | 1989 | 2701183 |
| a simple method for the collection of necator americanus larvae. | a simple method for the collection of third-stage larvae of necator americanus has been described. this technique provides repeated recovery of very clean larvae from cultures in moderate numbers. | 1989 | 2723389 |
| soil-transmitted helminthiases among inhabitants of an oil-palm plantation in west malaysia. | a total of 819 indian inhabitants (from 6 months to over 60 years of age) in an oil-palm plantation in west malaysia was examined for soil-transmitted helminthiases using the brine flotation and kato thick smear techniques. half (51.0%) of the inhabitants were found to be infected (33.9% had ascaris lumbricoides; 36.4% had trichuris trichiura and 15.6% had necator americanus). soil-transmitted helminthiases (both single and mixed infections) were significantly more common among children and youn ... | 1989 | 2760969 |
| ancylostoma duodenale and necator americanus: effect of temperature on egg development and mortality. | the development and mortality of the eggs of ancylostoma duodenale and necator americanus in distilled water were monitored over a range of temperatures between 15 and 35 degrees c. egg demography was examined within the context of a four-parameter mathematical model of development and mortality. over the range of temperatures studied, egg mortality (mu) was an increasing exponential function of temperature (t) measured in degrees celsius. a single model adequately described the mortality of bot ... | 1989 | 2797868 |
| hookworm and roundworm infections in farm-worker communities in the large-scale agricultural sector in zimbabwe. | surveys were carried out to assess the prevalences and intensities of hookworm and roundworm infections in 15 farm-worker communities in zimbabwe with poor living conditions. examination of 1635 faecal samples showed that hookworms (necator americanus and ancylostoma duodenale) were the commonest helminths (61.7% of infections). they were followed by ascaris lumbricoides and trichuris trichiura at less than 3%. there were striking differences in prevalences and intensities of infection of the di ... | 1989 | 2810452 |
| [light and electron microscopic observations on effects of tribendimidin on cuticle of necator americanus and small intestinal mucosa of infected golden hamsters]. | golden hamsters infected with necator americanus were treated orally with a new anthilmintic tribendimidin (n, n'-[bis-4'-(1-dimethyl amino ethylidene amino)phenyl] 1,4-phenyene dimethylidyne amine) at a single dose of 150 mg/kg. one h after medication, some worms showed cuticular swelling, fusion of transverse striations and attachment of host leucocytes onto the worm's damaged cuticular surface. four h post treatment, the cuticle revealed a moderate swelling or even erosion. meanwhile, the ven ... | 1989 | 2816407 |
| the epidemiological significance of the immune response to the cuticular collagen of necator americanus: a preliminary study in a hookworm-endemic area in papua new guinea. | 1990 | 1978540 | |
| the identification of a species-specific antigen from necator americanus. | a 17 kd protein of necator americanus was isolated by sds-page and used to raise monospecific antisera in rabbits. elisa and western blotting against a range of parasite extracts demonstrated the species specificity of this protein. it is expressed at all stages of the life-cycle, appears to be accumulated through the larval stages to adulthood, and can be localized in the oesophageal glands and cuticle of the adult parasite. the possible nature and diagnostic potential of this protein is discus ... | 1990 | 1696710 |
| [intestinal parasites and lactose malabsorption]. | breath-test was performed for diagnosis of lactose malabsorption in 50 gabonese children of normal nutritional status, aged 5 to 15 years, with parasites in stools, but without diarrhoea or digestive symptoms. control group was unparasitized and consisted of 17 children and 18 young adults living in the same area. parasites discovered by stool examination were ascaris lumbricoides in 76% of parasitized children, trichuris trichiura in 58%, giardia in 24%, entamoeba histolytica in 20%, schistosom ... | 1990 | 2078108 |
| [levamisole, mebendazole, thiabendazole. their effectiveness as helminthicides in african patients recently arrived in cuba. from 1987 to 1988]. | ninety one passengers coming from africa, carriers of geohelminthes, were selected and treated with helminthicides of large use in our country (levamisole, mebendazole, thiabendazole). an excellent effective response was obtained for ascaris lumbricoides (96.5%), and a good effective response was obtained for the rest of the parasites: trichuri trichiura (88.5%), strongyloides stercoralis (87.5%), and necator americanus (78.9), according to data of therapeutical response efficiency of the who. | 1990 | 2089506 |
| immunodiagnosis of taeniasis by coproantigen detection. | immunodiagnostic tests for taenia-specific faecal antigen based on polyclonal rabbit antisera against taenia saginata or taenia solium proglottid extracts in capture-type elisa assays have been developed. taenia-specific antigen was detected in detergent-solubilized faecal extracts from t. solium- and t. saginata-infected hosts. coproantigen from t. solium-infected hamsters did not cross-react with faeces from rodents infected with hymenolepis diminuta, h. citelli, h. microstoma, necator america ... | 1990 | 2092303 |