Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| asiatic acid enhances nrf2 signaling to protect hepg2 cells from oxidative damage through akt and erk activation. | asiatic acid (aa), a natural triterpene isolated from the plant centella asiatica, have antioxidative potential, but the molecular mechanism of aa against oxidative stress remains unclear. our study was performed to investigate the antioxidative effect of aa against oxidative stress and the antioxidative mechanism in tert-butyl hydroperoxide (t-bhp) -stimulated the hepg2 cells. the results showed that aa suppressed t-bhp-induced cytotoxicity, apoptosis, and reactive oxygen species (ros) generati ... | 2017 | 28110191 |
| the ameliorating effect of centella asiatica ethanolic extract on albino rats treated with isoniazid. | isoniazid, also called isonicotinyl hydrazine (inh), is a commonly used drug for treating tuberculosis. the main drawback is its toxic side effects. centella asiatica has long been used in the ayurvedic system of medicine owing to its wide medicinal properties. this study was designed to examine the effectiveness of c. asiatica ethanolic leaf extract (ca) on inh-treated albino rats. | 2017 | 27701138 |
| asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. | asiatic acid (aa), a pentacyclic triterpenoid, derived from the tropical medicinal plant centella asiatica is known to exhibit numerous pharmacological properties. we hypothesized that aa will have chemopreventive potential against 1,2-dimethylhydrazine (dmh)-induced experimental colon carcinogenesis in male wistar rats. rats were arbitrarily divided into six groups. group i rats were processed as control. group ii rats received aa (8 mg/kg b.w., p.o.) and groups iii-vi rats received subcutaneou ... | 2017 | 28004603 |
| comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of centella asiatica, eca 233 and their respective pure compound given separately in rats. | 1. eca 233, the standardised extract of centella asiatica, contains not less than 80% triterpenoid glycosides, in a madecassoside:asiaticoside ratio of 1.5 (±0.5):1. 2. the pharmacokinetic comparison of madecassoside and asiaticoside was performed in rats following intravenous and oral administration of eca 233, or an equivalent dose of the individual compounds. blood, tissues, urine and faeces were collected after dosing to determine drug and metabolite levels using liquid chromatography-tandem ... | 2017 | 28001462 |
| centella asiatica attenuates aβ-induced neurodegenerative spine loss and dendritic simplification. | the medicinal plant centella asiatica has long been used to improve memory and cognitive function. we have previously shown that a water extract from the plant (caw) is neuroprotective against the deleterious cognitive effects of amyloid-β (aβ) exposure in a mouse model of alzheimer's disease, and improves learning and memory in healthy aged mice as well. this study explores the physiological underpinnings of those effects by examining how caw, as well as chemical compounds found within the extr ... | 2017 | 28279707 |
| ethnobotanical survey of herbal tea plants from the traditional markets in chaoshan, china. | herbal tea, which refers to "cooling tea", "cool beverage", or "liáng chá" in china, includes a range of drinks with heat-clearing and detoxification qualities. herbal tea plants are great contributive to the health and prosperity of chaoshan people. the aim of the study was to document herbal tea plant species used and commercialized as "liáng chá" in chaoshan area, to facilitate the use and development of herbal tea enterprises, and to promote the further development of national herbal tea. | 2017 | 28249822 |
| partial-thickness burn wounds healing by topical treatment: a randomized controlled comparison between silver sulfadiazine and centiderm. | burns are common event and associated with a high incidence of death, disability, and high costs. centella asiatica (l.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. on the basis of previous studies, we compared the efficacy of centiderm versus silver sulfadiazine (ssd) in partial thickness burning patients. | 2017 | 28248871 |
| asiaticoside: attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity. | asiaticoside (as), a triterpenoid saponin isolated from the indian medicinal herb centella asiatica is known to exert a neuroprotective effect by attenuating the neurobehavioral, neurochemical and pathological changes in animal models. however, its potential neuroprotection in rotenone-induced hemiparkinsonism which implicates phospholipid-mediated neurotransmission remains unclear. therefore, we have investigated the neuroprotective effects of as in rat model of rot-infused hemiparkinsonism wit ... | 2017 | 28238857 |
| neurotrophic effect of asiatic acid, a triterpene of centella asiatica against chronic 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine hydrochloride/probenecid mouse model of parkinson's disease: the role of mapk, pi3k-akt-gsk3β and mtor signalling pathways. | regulation of various signalling (ras-mapk, pi3k and akt) pathways by augmented activity of neurotrophic factors (ntfs) could prevent or halt the progress of dopaminergic loss in parkinson's disease (pd). various in vitro and in vivo experimental studies indicated anti-parkinsonic potential of asiatic acid (aa), a pentacyclic triterpene obtained from centella asiatica. so the present study is designed to determine the neurotrophic effect of aa against 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyrid ... | 2017 | 28181071 |
| asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. | asiatic acid (aa), a pentacyclic triterpene found in centella asiatica, displays significant anti-proliferative effects on cancer cells in vitro although the underlying mechanism of this effect remains unknown. this study investigated the efficacy and mechanism of action of aa against lung cancer both in vivo and in vitro. using the mtt assay, aa was found to induce apoptosis in a dose- and time-dependent manner, an effect enhanced by pretreatment with an autophagy inhibitor. it also elevated ex ... | 2017 | 28119810 |
| effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial. | we evaluated the efficacy of oral administration of a mixture of diosmin, coumarin glycosides, and centella asiatica (venoplant®) in preventing bleeding, pain, and thrombosis of internal and external hemorrhoids after stapled anopexy (sa). | 2017 | 27815700 |
| pva-peg physically cross-linked hydrogel film as a wound dressing: experimental design and optimization. | the development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. polyvinyl alcohol/polyethylene glycol (pva/peg) hydrogels loaded with asiaticoside, a standardized rich fraction of centella asiatica, were successfully developed using the freeze-thaw method. response surface methodology with box-behnken experimental design was employed to optimize the hydrogels. the hydrogels were characterized and optimized by gel fraction, swellin ... | 2017 | 28378604 |
| synergistic combinations of five single drugs from centella asiatica for neuronal differentiation. | to identify alternatives of nerve growth factor, which could promote nf68 protein expression and contribute toward neuronal differentiation, five compounds namely: asiatic acid, madecassic, madecassoside, quercetin, and isoquercetin, obtained from centella asiatica, were examined for their neuronal differentiation effects on pc12 cells. c. asiatica has been applied as an effective herbal medicine for the treatment of various diseases, including depression. according to a statistical design of ex ... | 2017 | 27893605 |
| madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of th17 toward treg cells via the pparγ/ampk/acc1 pathway. | the imbalance between th17 and treg cells substantially contributes to the intestinal immune disturbance and subsequent tissue injury in ulcerative colitis. the triterpenoid-rich fraction of centella asiatica was able to ameliorate dextran sulfate sodium-induced colitis in mice. here we explored its active ingredient and underlying mechanism with a focus on restoring the th17/treg balance. the four main triterpenoids occurring in c. asiatica were shown to attenuate colitis in mice by oral admini ... | 2017 | 28358365 |
| anti-inflammatory effect of titrated extract of centella asiatica in phthalic anhydride-induced allergic dermatitis animal model. | centella asiatica has potent antioxidant and anti-inflammatory properties. however, its anti-dermatitic effect has not yet been reported. in this study, we investigated the anti-dermatitic effects of titrated extract of centella asiatica (teca) in a phthalic anhydride (pa)-induced atopic dermatitis (ad) animal model as well as in vitro model. an ad-like lesion was induced by the topical application of five percent pa to the dorsal skin or ear of hos:hr-1 mouse. after ad induction, 100 μl of 0.2% ... | 2017 | 28358324 |
| asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (blm) via suppressing pro-fibrotic and inflammatory signaling pathways. | idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and limited therapeutic strategies. in addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. asiatic acid (aa) is a triterpenoid, isolated from centella asiatica, exhibiting efficient anti-inflammatory and anti-oxidative activities. in our study, we attempted to explore the effect of asiatic acid on bleomycin (blm)-induced pulmonary fibrosis in mice. the findings in ... | 2017 | 28320097 |
| moisturizing and antiinflammatory properties of cosmetic formulations containing centella asiatica extract. | centella asiatica extract is a rich source of natural bioactive substances, triterpenoid saponins, flavonoids, phenolic acids, triterpenic steroids, amino acids and sugars. thus, many scavenging free radicals, exhibit antiinflammatory activity and affect on the stratum corneum hydration and epidermal barrier function. the aim of the present study was to evaluate the in vivo moisturizing and antiinflammatory properties of cosmetic formulations (oil-in-water emulsion cream and hydrogel) containing ... | 2017 | 27168678 |
| artificial neural network-based model for the prediction of optimal growth and culture conditions for maximum biomass accumulation in multiple shoot cultures of centella asiatica. | an artificial neural network (ann)-based modelling approach is used to determine the synergistic effect of five major components of growth medium (mg, cu, zn, nitrate and sucrose) on improved in vitro biomass yield in multiple shoot cultures of centella asiatica. the back propagation neural network (bpnn) was employed to predict optimal biomass accumulation in terms of growth index over a defined culture duration of 35 days. the four variable concentrations of five media components, i.e. mgso4 ( ... | 2017 | 27068291 |
| preclinical safety assessment of standardized extract of centella asiatica (l.) urban leaves. | centella asiatica (ca) leaves extract has been shown therapeutic potential. however, safety information is lacking. | 2017 | 26862255 |
| pycnogenol® and centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. | the aim of this study was to evaluate the effect of the nutritional supplements pycnogenol® and centella asiatica (ca) on atherosclerosis progression in low-risk, asymptomatic subjects with carotid or femoral stenosing plaques. | 2017 | 26505327 |
| wound-healing effect of electrospun gelatin nanofibres containing centella asiatica extract in a rat model. | centella asiatica (ca) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. this study demonstrated that ca extract facilitates the wound-repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. gelatin nanofibres containing c. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound-healing activity in a rat model. the wound areas of rat skin treated with ... | 2017 | 25711743 |
| centella asiatica leaf extract protects against indomethacin-induced gastric mucosal injury in rats. | the present study evaluated the protective effect of centella asiatica (gotu kola) leaf extract (cae) against indomethacin (ind)-induced gastric mucosal injury in rats. gastric mucosal injury was induced by the oral administration of ind to the rats after a 24 h fast. cae (50 or 250 mg/kg) or lansoprazole (a reference drug) was orally administrated 30 min before the ind administration, and 5 h later, the stomachs were removed to quantify the lesions. orally administered cae significantly reduced ... | 2016 | 26469560 |
| carotid plaque stabilization induced by the supplement association pycnogenol® and centella asiatica (centellicum®). | aim of this registry study was the evaluation of the stability of carotid plaques by ultrasound in asymptomatic subjects with high oxidative stress following supplementation with a combination of the extract from bark of pinus pinaster, pycnogenol®, with an extract from centella asiatica leaves, centellicum®. | 2016 | 26496510 |
| chlorogenic acids biosynthesis in centella asiatica cells is not stimulated by salicylic acid manipulation. | exogenous application of synthetic and natural elicitors of plant defence has been shown to result in mass production of secondary metabolites with nutraceuticals properties in cultured cells. in particular, salicylic acid (sa) treatment has been reported to induce the production of phenylpropanoids, including cinnamic acid derivatives bound to quinic acid (chlorogenic acids). centella asiatica is an important medicinal plant with several therapeutic properties owing to its wide spectrum of seco ... | 2016 | 26922726 |
| effect of salicylic acid on expression level of genes related with isoprenoid pathway in centella (centella asiatica (l.) urban) cells. | in this study, we report the expression level of casqs, cabas and cacys, the genes involved in phytosterol and triterpene metabolic pathway of centella (centella asiatica (l.) urban), in cells elicited with salicylic acid (50-200 µm). reverse transcription-polymerase chain reaction (rt-pcr) and northern blot analysis indicated casqs, cabas, and cacys genes expressed in both the wild-type and cultured cells (with and without elicitation). in elicited cells, expressions of casqs, cabas, and cacys ... | 2016 | 28330156 |
| effects of metal-contaminated soils on the accumulation of heavy metals in gotu kola (centella asiatica) and the potential health risks: a study in peninsular malaysia. | centella asiatica is a commonly used medicinal plant in malaysia. as heavy metal accumulation in medicinal plants which are highly consumed by human is a serious issue, thus the assessment of heavy metals in c. asiatica is important for the safety of consumers. in this study, the heavy metal accumulation in c. asiatica and the potential health risks were investigated. samples of c. asiatica and surface soils were collected from nine different sites around peninsular malaysia. the concentration o ... | 2016 | 26687083 |
| centella asiatica extract protects against amyloid β1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. | centella asiatica ( léi gōng gēn) is a traditional medicinal herb with high antioxidant activity, which decreases amyloid-β (aβ) deposition in the brain. at the same time, aggregated aβ-induced oxidative stress is the trigger in the pathogenesis of alzheimer's disease (ad). here, we investigated the ability of c. asiatica ethanol extract (cae) to protect pc12 and imr32 cells from aβ1-40-induced production of reactive oxygen species (ros) and concomitant neurotoxicity. aggregated aβ1-40 treatment ... | 2016 | 27774420 |
| neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated sh-sys5y cells. | parkinson's disease (pd) is a chronic neurodegenerative disease, manifested due to the loss of dopaminergic neurons, which ultimately leads to impaired movement in elderly populations. the pathogenesis of pd is associated with numerous factors including oxidative stress, mitochondrial dysfunction and apoptosis. there is no effective therapy available to cure or halt the progression of this disease still now. asiatic acid (aa) is a triterpene extracted from centella asiatica has been reported as ... | 2016 | 26856988 |
| possible involvement of nitric oxide modulatory mechanisms in the neuroprotective effect of centella asiatica against sleep deprivation induced anxiety like behaviour, oxidative damage and neuroinflammation. | sleep deprivation (sd) is an experience of inadequate or poor quality of sleep that may produce significant alterations in multiple neural systems. centella asiatica (ca) is a psychoactive medicinal herb with immense therapeutic potential. the present study was designed to explore the possible nitric oxide (no) modulatory mechanism in the neuroprotective effect of ca against sd induced anxiety like behaviour, oxidative damage and neuroinflammation. male laca mice were sleep deprived for 72 h, an ... | 2016 | 26848139 |
| purification of a recombinant polyhistidine-tagged glucosyltransferase using immobilized metal-affinity chromatography (imac). | short peptide tags genetically fused to recombinant proteins have been widely used to facilitate detection or purification without the need to develop specific procedures. in general, an ideal affinity tag would allow the efficient purification of tagged proteins in high yield, without affecting its function. here, we describe the purification steps to purify a recombinant polyhistidine-tagged glucosyltransferase from centella asiatica using immobilized metal affinity chromatography. | 2016 | 26843168 |
| from plant extract to a cdna encoding a glucosyltransferase candidate: proteomics and transcriptomics as tools to help elucidate saponin biosynthesis in centella asiatica. | centella asiatica (l.) urban (apiaceae), a small annual plant that grows in india, sri lanka, malaysia, and other parts of asia, is well-known as a medicinal herb with a long history of therapeutic uses. the bioactive compounds present in c. asiatica leaves include ursane-type triterpene sapogenins and saponins-asiatic acid, madecassic acid, asiaticoside, and madecassoside. various bioactivities have been shown for these compounds, although most of the steps in the biosynthesis of triterpene sap ... | 2016 | 26843164 |
| antifibrotic effect of centella asiatica linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts. | the aim of the present study was to investigate the in vitro antifibrogenic effects of centella asiatica linn (ca) and its bioactive triterpene aglycone asiatic acid (aa) on arecoline-induced fibrosis in primary human buccal fibroblasts (hbf). | 2016 | 26840561 |
| centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice. | this study investigates the cognitive enhancing effects of the plant centella asiatica which is widely used ayurvedic and traditional chinese medicine. | 2016 | 26785167 |
| metabolic alteration in obese diabetes rats upon treatment with centella asiatica extract. | 'pegaga' is a traditional malay remedy for a wide range of complaints. among the 'pegaga', centella asiatica has been used as a remedy for diabetes mellitus. thus, we decided to validate this claim by evaluating the in vivo antidiabetic property of c. asiatica (ca) on t2dm rat model using the holistic (1)h nmr-based metabolomics approach. | 2016 | 26775274 |
| anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles. | asiatic acid (aa), a pentacyclic triterpene found in centella asiatica, has shown neuroprotective and anti-cancer activity against glioma. however, owing to its poor aqueous solubility, effective delivery and absorption across biological barriers, in particular the blood brain barrier (bbb), are challenging. solid lipid nanoparticles (slns) have shown a promising potential as a drug delivery system to carry lipophilic drugs across the bbb, a major obstacle in brain cancer therapy. nevertheless, ... | 2016 | 26775062 |
| an investigation of the differential effects of ursane triterpenoids from centella asiatica, and their semisynthetic analogues, on gabaa receptors. | the ursane triterpenoids, asiatic acid 1 and madecassic acid 2, are the major pharmacological constituents of centella asiatica, commonly known as gotu kola, which is used traditionally for the treatment of anxiety and for the improvement of cognition and memory. using the two-electrode voltage-clamp technique, these triterpenes, and some semisynthetic derivatives, were found to exhibit selective negative modulation of different subtypes of the gabaa receptor expressed in xenopus laevis oocytes. ... | 2016 | 27062315 |
| phlebotonics for venous insufficiency. | chronic venous insufficiency (cvi) is a common condition caused by valvular dysfunction with or without associated obstruction, usually in the lower limbs. it might result in considerable discomfort with symptoms such as pain, itchiness and tiredness in the legs. patients with cvi may also experience swelling and ulcers. phlebotonics are a class of drugs often used to treat cvi. this is an update of a review first published in 2005. | 2016 | 27048768 |
| safety assessment of selected medicinal food plants used in ayurveda through cyp450 enzyme inhibition study. | andrographis paniculata, bacopa monnieri, centella asiatica are mentioned in ayurveda for the management of neurodegenerative disorders. these plants and their phytomolecules like andrographolide, bacoside a and asiaticoside were studied for their inhibition potential on pooled cyp450 as well as human cyp3a4, cyp2d6, cyp2c9 and cyp1a2 by cyp-co complex assay and fluorogenic assay respectively followed by ic50 determination. quantification of bioactive compounds present in the extracts was done b ... | 2016 | 27030208 |
| asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of pi3k/akt/mtor signalling. | context asiatic acid, a triterpenoid compound extracted from the tropical medicinal plant centella asiatica (family: apiaceae), has exhibited various biological activities. objective this study was performed to investigate the cytotoxic effects of asiatic acid on human ovarian cancer cells. materials and methods skov3 and ovcar-3 ovarian cancer cells were exposed to different concentrations of asiatic acid (10-100 μg/ml) for 72 or 48 h. cell viability, colony formation, cell cycle distribution, ... | 2016 | 26984021 |
| bioassay-guided isolation of wound healing active compounds from echium species growing in turkey. | the roots and root barks of echium sp. have been used to treat ulcers, burns and wounds in traditional turkish medicine. | 2016 | 26947902 |
| barrier protective effect of asiatic acid in tnf-α-induced activation of human aortic endothelial cells. | endothelial cell activation is characterized by increased endothelial permeability and increased expression of cell adhesion molecules (cams). this allows monocyte adherence and migration across the endothelium to occur and thereby initiates atherogenesis process. asiatic acid is a major triterpene isolated from centella asiatica (l.) urban and has been shown to possess anti-oxidant, anti-hyperlipidemia and anti-inflammatory activities. | 2016 | 26926181 |
| quantitative determination of catechin as chemical marker in pediatric polyherbal syrup by hplc/dad. | vivabon syrup is a balanced composition of dietary ingredients of phytopharmaceutical nature for maintaining the physique, vigor, vitality and balanced growth of children. the herbal ingredients of pediatric syrup are rich in bioflavonoid, proteins, vitamins, glycosides and trace elements. vivabon is formulated with herbal drugs such as phoenix sylvestris, emblica officinalis, withania somnifera, centella asiatica, amomum subulatum, zingiber officinalis, trigonella foenum-graecum, centaurea behe ... | 2016 | 27165575 |
| isolation and identification of an antifungal compound from endophytic streptomyces sp. cen26 active against alternaria brassicicola. | 2,5-bis(hydroxymethyl)furan monoacetate (bhmf-oac) compound was isolated from the culture filtrate secreted by streptomyces sp. cen26, an endophytic actinomycete found in the root nodes of centella asiatica (l.) urban. the compound was purified using various chromatographic techniques and bioassay-guided fractionation. the compound was then identified through a structural characterization using (1) h, (13) c-nmr and ms analysis. after the purification and identification process, a series of expe ... | 2016 | 27163966 |
| madecassic acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ros-mediated endoplasmic reticulum stress. | madecassic acid (ma) is an abundant triterpenoid in centella asiatica (l.) urban. (apiaceae) that has been used as a wound-healing, anti-inflammatory and anti-cancer agent. up to now, the effects of ma against oxidative stress remain unclear. in this study, we investigated the effect of ma and its mechanisms on hypoxia-induced human retinal microvascular endothelial cells (hrmecs). hrmecs were pre-treated with different concentrations of ma (0-50μm) for 30min before being incubated under hypoxia ... | 2016 | 27728894 |
| in vitro and in vivo antioxidant, anti-hyperlipidemic properties and chemical characterization of centella asiatica (l.) extract. | the study aimed to identify the phenolic compounds present in centella asiatica (l.) (c. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. the anti-hyperlipidemic effects of c. asiatica extract (cae) were evaluated in high cholester ... | 2016 | 27840607 |
| protective effects of centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats. | oxidative stress in liver injury is a major pathogenetic factor in the progression of liver damage. centella asiatica (l.) urban, known in the united states as gotu kola, is widely used as a traditional herbal medicine in chinese or indian pennywort. the efficacy of centella asiatica is comprehensive and is used as an anti‑inflammatory agent, for memory improvement, for its antitumor activity and for treatment of gastric ulcers. the present study investigated the protective effects of centella a ... | 2016 | 27748812 |
| stimulatory effects of acibenzolar-s-methyl on chlorogenic acids biosynthesis in centella asiatica cells. | centella asiatica is a perrenial herb that grows in tropical regions with numerous medicinal properties mostly attributed to the presence of pentacyclic triterpenoids. interestingly, this plant also possess a significant amount of phenylpropanoid-derived chlorogenic acids (cgas) that have recently been reported to confer neuroprotective properties. in a biotechnological attempt to increase the biosynthesis of cga-derivatives in cultured centella cells, acibenzolar-s-methyl was applied as a xenob ... | 2016 | 27733862 |
| neuroprotective properties of madecassoside from centella asiatica after hypoxic-ischemic injury. | madecassoside is one of increasingly used constituent of centella asiatica, a frequently prescribed crude drug in south eastern asia and china for wound healing. in the present experiment, it exposes the neuroprotective nature of madecassoside in gt1-7 cell lines, further, which the antioxidant activities are performed. the cellular toxicity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay with increased cell viability with ic50 2.5µg/ml. the regulation ... | 2016 | 28375122 |
| pharmacokinetics of a standardized extract of centella asiatica eca 233 in rats. | eca 233, a standardized extract of centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. the present study aimed to explore the disposition kinetics of eca 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. the extract was intravenously or orally administered at doses from 50 to 200 mg/kg. plasma, tissues, urine, and feces were collected at time points from 0 to 48 h after dosing. the levels of madecassoside ... | 2016 | 27992940 |
| asiatic acid attenuates myocardial ischemia/reperfusion injury via akt/gsk-3β/hif-1α signaling in rat h9c2 cardiomyocytes. | myocardial ischemic/reperfusion injury results from severe impairment of coronary blood supply and leads to irreversible cell death, with limited therapeutic possibilities. asiatic acid is a pentacyclic triterpenoid derived from the tropical medicinal plant centella asiatica and serves a variety of bioactivities. in this study, we determined the effect of asiatic acid on myocardial ischemia/reperfusion injury and investigated the underlying mechanisms, using an in vitro rat h9c2 cardiomyocytes m ... | 2016 | 27657024 |
| phytoremediation of iron from red soil of tropical region by using centella asiatica. | the accumulation and removal efficiency of fe by centella asiatica was carried out at various fe concentrations in soil treatments (0, 50, 100, 150 and 200 mg fe/kg soil). iron accumulation in different parts of c. asiatica (leaf, stem and root) was analyzed by atomic absorption spectrophotometer (aas). factorial experiment with a completely randomized design and duncan's test were used for data analyses. the results revealed that c. asiatica have the ability to uptake and accumulate fe signific ... | 2016 | 26940261 |
| indian herbs for the treatment of neurodegenerative disease. | ayurveda, an ancient system of medicine that is indigenous to india, is believed to be the world's oldest comprehensive health-care system and is now one of the most recognized and widely practiced disciplines of alternative medicine in the world. medicinal herbs have been in use for treating diseases since ancient times in india. ayurvedic therapies with medicinal herbs and herbomineral products generally provide relief without much adverse effects even after prolonged administration. neurodege ... | 2016 | 27651261 |
| efficacy of natural compounds in neurodegenerative disorders. | neurodegenerative disorders represent clusters of serious diseases that results in progressive deterioration of normal structure and physiology of central nervous system. pathophysiology of alzheimer's, parkinson's or other neurodegenerative disorders involves multifaceted permutation of genetic and environmental factors. combinations of lifestyle modification linked with environmental factor jointly or alone represent the largest share of cases of these disorders. etiology of such neuronal dege ... | 2016 | 27651251 |
| burn wound healing properties of asiaticoside and madecassoside. | the healing of burn wounds has been widely characterized to be highly intricate, involving processes such as neo-vascularization, granulation, re-epithelialization, inflammation and wound contraction. various therapies are available for the management of burn wounds; however, a truly effective therapeutic strategy has yet to be identified due to safety issues. the aim of the present study was to assess and confirm the burn wound healing properties of the compounds asiaticoside (ae) and madecasso ... | 2016 | 27588048 |
| mad ointment ameliorates imiquimod-induced psoriasiform dermatitis by inhibiting the il-23/il-17 axis in mice. | psoriasis is a chronic auto-immune inflammation disease with skin lesions and abnormal keratinocyte proliferation. the il-23/il-17 axis plays an important role in the pathogenesis of psoriasis. madecassoside (mad) was the most important constituents isolated from centella asiatica, which has long been used in dermatology, and it is supposed that mad may have effects on psoriasis. in the present study, the balb/c mice ear and back skin received imq for 6 consecutive days to induce psoriasis-like ... | 2016 | 27540765 |
| recent updates in neuroprotective and neuroregenerative potential of centella asiatica. | centella asiatica, locally well known in malaysia as pegaga, is a traditional herb that has been used widely in ayurvedic medicine, traditional chinese medicine, and in the traditional medicine of other southeast asian countries including malaysia. although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. in addition to past studies, recent studies also discovered and/or reconfirmed that c. asiatica acts ... | 2016 | 27540320 |
| asiatic acid inhibits pulmonary inflammation induced by cigarette smoke. | asiatic acid (aa) is one of the major components of titrated extract of centella asiatica (teca), which has been reported to possess antioxidant and anti-inflammatory activities. the purpose of this study was to investigate the protective effect of aa on pulmonary inflammation induced by cigarette smoke (cs). aa significantly attenuated the infiltration of inflammatory cells in bronchoalveolar lavage fluid (balf) of cs exposure mice. aa also decreased ros production and ne activity, and inhibite ... | 2016 | 27494684 |
| chemical structures, production and enzymatic transformations of sapogenins and saponins from centella asiatica (l.) urban. | centella asiatica (l.) urban is a medicinal herb traditionally used in asiatic countries for its multiple therapeutic properties, essentially due to its accumulation of specific pentacylic triterpenoid saponins, mainly asiaticoside and madecassoside and the corresponding sapogenins. this review summarizes the updated knowledge about the chemical structures of about forty centelloids, found as minor metabolites in centella, and all derived from ursane and oleane ring patterns. similarly, the most ... | 2016 | 27491750 |
| accelerated stability studies on dried extracts of centella asiatica through chemical, hplc, hptlc, and biological activity analyses. | regulatory guidelines recommend systematic stability studies on a herbal product to establish its shelf life. in the present study, commercial extracts (types i and ii) and freshly prepared extract (type iii) of centella asiatica were subjected to accelerated stability testing for 6 months. control and stability samples were evaluated for organoleptics, ph, moisture, total phenolic content (tpc), asiatic acid, kaempherol, and high-performance thin layer chromatography fingerprints, and for antio ... | 2016 | 27486096 |
| identification of centella asiatica's effective ingredients for inducing the neuronal differentiation. | centella asiatica, commonly known as gotu kola, has been widely used as a traditional herb for decades. yet, the study on which compounds or compound combinations actually lead to its brain benefits remains scarce. to study the neuroprotection effects of centella asiatica, neuronal differentiation of pc12 cells was applied. in our pilot study, we isolated 45 centella asiatica fractions and tested their abilities for inducing neuronal differentiation on pc12 cells. the most effective fraction sho ... | 2016 | 27446228 |
| asiatic acid inhibits lipopolysaccharide-induced acute lung injury in mice. | asiatic acid (aa), a major triterpene isolated from centella asiatica (l.) urban, is known to exert various pharmacological activities, including anti-inflammatory and antioxidant effects. the aim of this study was to evaluate the anti-inflammatory effects of aa on lipopolysaccharide (lps)-induced acute lung injury (ali) and clarify the underlying mechanisms. lung pathological changes were assessed by h&e staining. the myeloperoxidase (mpo) activity was detected by mpo assay. the levels of infla ... | 2016 | 27395046 |
| effectiveness of gotu kola extract 750 mg and 1000 mg compared with folic acid 3 mg in improving vascular cognitive impairment after stroke. | this study aimed to determine the effectiveness of gotu kola (centella asiatica) in improving cognitive function in patients with vascular cognitive impairment (vci). this study uses a quasi-experimental design. subjects in this study were patients with poststroke cognitive impairment who were treated at two hospitals in yogyakarta, indonesia. the number of subjects was 48: 17 subjects were treated with 1000 mg/day of gotu kola extract, 17 subjects treated with 750 mg/day of gotu kola extract, a ... | 2016 | 27340413 |
| asiatic acid uncouples respiration in isolated mouse liver mitochondria and induces hepg2 cells death. | asiatic acid, one of the triterpenoid components isolated from centella asiatica, has received increasing attention due to a wide variety of biological activities. to date, little is known about its mechanisms of action. here we examined the cytotoxic effect of asiatic acid on hepg2 cells and elucidated some of the underlying mechanisms. asiatic acid induced rapid cell death, as well as mitochondrial membrane potential (mmp) dissipation, atp depletion and cytochrome c release from mitochondria t ... | 2016 | 27288117 |
| evaluation of the topical spray containing centella asiatica extract and its efficacy on excision wounds in rats. | centella asiatica was extracted by methanol. the assay content of triterpenes in the extract was 0.12 % asiatic acid, 0.54 % madecassic acid, 0.25 % asiaticoside and 1.02 % madecassoside. the extract was complexed with hydroxypropyl-β-cyclodextrin (hp-β-cd) and formulated with eudragit e100, glycerol, peg 400, copovidone, ethanol and purified water. a clear yellowish solution (f1-f8) was obtained. the formulations had a ph of 5.5-6.0 with viscosity in the range of 20-60 mpa s, surface tension 20 ... | 2016 | 27279066 |
| ctg-loaded liposomes as an approach for improving the intestinal absorption of asiaticoside in centella total glucosides. | centella total glucosides (ctg),obtained from centella asiatica (l.), have been shown to possess a multitude of pharmacological activities, however, oral administeration of ctg failed to fulfill their therapeutic potentials due to the low bioavailability. in this study, the author prepared the liposomes encapsulated ctg using the ethanol injection method in order to enhance their intestinal absorption. the average particle size and the polydispersityindex(pdi) of ctg-loaded liposome in a batch a ... | 2016 | 27251012 |
| asiatic acid prevents the deleterious effects of valproic acid on cognition and hippocampal cell proliferation and survival. | valproic acid (vpa) is commonly prescribed as an anticonvulsant and mood stabilizer used in the treatment of epilepsy and bipolar disorder. a recent study has demonstrated that vpa reduces histone deacetylase (hdac) activity, an action which is believed to contribute to the effects of vpa on neural stem cell proliferation and differentiation which may explain the cognitive impairments produced in rodents and patients. asiatic acid is a triterpenoid derived from the medicinal plant centella asiat ... | 2016 | 27213437 |
| clinical efficacy test of polyester containing herbal extract dressings in burn wound healing. | technological advancement has assisted in developing various availabilities of wound products that help in not only in healing and preventing infection but also in providing patients' comfort and pain reduction during application. however, most of advanced wound healing products in thailand were imported at high costs to patients. nowadays, there are increased numbers of local researches of herbs that could provide healing environment for successful wound care. herbal wound products are currentl ... | 2016 | 27440796 |
| effects of plants on osteogenic differentiation and mineralization of periodontal ligament cells: a systematic review. | this systematic review aimed to evaluate the effects of plants on osteogenic differentiation and mineralization of human periodontal ligament cells. the included studies were selected using five different electronic databases. the reference list of the included studies was crosschecked, and a partial gray literature search was undertaken using google scholar and proquest. the methodology of the selected studies was evaluated using grade. after a two-step selection process, eight studies were ide ... | 2016 | 26822584 |
| rapid screening and identification of phenolic antioxidants in hydrocotyle sibthorpioides lam. by uplc-esi-ms/ms. | the aim of the study was to identify the phenolic compounds present in hydrocotyle sibthorpioides (hs), centella asiatica (ca) and amaranthus viridis (av) extracts and investigate their respective antioxidant activities. herein, an ultra-high pressure liquid chromatography-mass spectrometer (uplc-ms/ms) analytical method has been developed for the separation, and systematic characterization of the phenolic compounds in hs, ca and av extracts and was compared along with ten standard phenolic comp ... | 2016 | 26948646 |
| large scale screening of ethnomedicinal plants for identification of potential antibacterial compounds. | the global burden of bacterial infections is very high and has been exacerbated by increasing resistance to multiple antibiotics. antibiotic resistance leads to failed treatment of infections, which can ultimately lead to death. to overcome antibiotic resistance, it is necessary to identify new antibacterial agents. in this study, a total of 662 plant extracts (diverse parts) from 222 plant species (82 families, 177 genera) were screened for antibacterial activity using the agar cup plate method ... | 2016 | 26985889 |
| anti-quorum sensing activity of flavonoid-rich fraction from centella asiatica l. against pseudomonas aeruginosa pao1. | inhibition of quorum sensing (qs), a cell-density dependent regulation of gene expression in bacteria by autoinducers is an attractive strategy for the development of antipathogenic agents. | 2016 | 24856426 |
| in vitro antimicrobial activity of spices and medicinal herbs against selected microbes associated with juices. | in the present investigation, comparison of antimicrobial activities of different spices, curcuma longa, zingiber officinale, and mentha arvensis, and medicinal herbs, such as withania somnifera, rauvolfia serpentina, emblica officinalis, terminalia arjuna, and centella asiatica, was evaluated. different extraction solvents (acetone, methanol, ethanol, and water) were used and extracts were examined against bacillus cereus, serratia sp., rhodotorula mucilaginosa, aspergillus flavus, and penicill ... | 2016 | 26880927 |
| endophytic fungal isolate mediated biosynthesis of silver nanoparticles and their free radical scavenging activity and anti microbial studies. | the present study reports that the biosynthesis of agnps using an endophytic fungus isolated from the ethnomedicinal plant centella asiatica. the endophytic fungus was identified as aspergillus versicolor ent7 based on 18s rrna gene sequencing (ncbi accession number kf493864). the agnps synthesized were characterized by uv-visible spectroscopy, fourier transform infra-red spectroscopy (ftir), transmission electron microscopy (tem), x-ray diffraction (xrd), particle size analyzer, and zeta potent ... | 2016 | 28330204 |
| in vitro and in vivo anti-helicobacter pylori activities of centella asiatica leaf extract. | helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. however, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. the aim of this study was to investigate the activities of centella asiatica leaf extract (cae) against h. pylori both in vitro and in vivo. the minimum inhibitory concentrations (mics) against 55 clinically isolated strains of ... | 2016 | 27752495 |
| gotu kola (centella asiatica): nutritional properties and plausible health benefits. | centella asiatica l. (gotu kola) is a nutritionally important plant and a valued traditional medicine in south east asia. in this review, the chemical composition, nutritional values, and health benefits of c. asiatica have been discussed in detail to emphasize its usage as traditional food and medicine. c. asiatica is one of the most commonly used green leafy vegetables (glvs) in some countries including sri lanka due to its high amounts of medicinally important triterpenoids and beneficial car ... | 2015 | 26602573 |
| unusual microbial lactonization and hydroxylation of asiatic acid by umbelopsis isabellina. | asiatic acid (1) is a natural triterpenoid isolated from centella asiatica. this paper reports the microbial transformation of asiatic acid by an endophytic fungus umbelopsis isabellina to obtain derivatives potentially useful for further studies. incubation of asiatic acid with u. isabellina afforded two derivatives 2α,3β,7β, 23-tetrahydroxyurs-12-ene-28-oic acid (2) and 2α,3β,7β,23-tetrahydroxyurs-11-ene-28,13-lactone (3). the structures of these compounds were elucidated by spectral data. com ... | 2015 | 26194478 |
| a review of commercially important african medicinal plants. | data on the relative importance and research status of commercially relevant african medicinal plants are needed for developing new research strategies in order to stimulate much-needed ethnopharmacological research and to promote the commercialization of african plants. | 2015 | 26498493 |
| bioavailability of calcium and its absorption inhibitors in raw and cooked green leafy vegetables commonly consumed in india--an in vitro study. | the objectives of this research were to assess the bioavailability of calcium using equilibrium dialysis after simulated gastric digestion method in 20 commonly consumed green leafy vegetables (glvs) from the typical indian diet, provide data on the content of calcium absorption inhibitors, like oxalate, phytate, tannin and dietary fibres, and evaluate the inhibitory effect of these compounds on calcium bioavailability in raw and cooked glvs. cooking did not affect significantly calcium bioavail ... | 2015 | 25306367 |
| the potential of asiaticoside for tgf-β1/smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension. | asiaticoside (as) is a saponin monomer extracted from the medicinal plant centella asiatica, which has a variety of biological effects. we intended to investigate the effects of asiaticoside on a hypoxia-induced pulmonary hypertension (hph) rat model and examine the possible effects of asiaticoside on tgf-β1/smad signaling in vivo and in vitro. | 2015 | 26209140 |
| synergy effects of three plant extracts on protection of gastric mucosa. | the gastric mucosa protection effect of three natural plant extracts, hericium erinaceus (he), centella asiatica (ca) and amomum villosum (av), were evaluated using the indomethacin damage model. compared with a single extract, a combination of he/ca/av, especially with the ratios of 80:10:10, 45:45:10 and 45:10:45, showed significant synergistic effects for protection of the gastric mucosa with gastric ulcer inhibition rates of 97.8 ± 0.7%, 86.5 ± 2.8% and 86.1 ± 3.6%, respectively. microscopic ... | 2015 | 26749844 |
| seasonal variation of triterpenes and phenolic compounds in australian centella asiatica (l.) urb. | specific triterpenes, phenolic acids and flavonoids in centella asiatica have been found to be bioactive. harvesting the plant when these putative bioactive compounds are at their highest concentrations would provide consistency in their chemical profile, thus ensuring the quality and efficacy of derived medicinal products. | 2015 | 26219274 |
| asiaticoside inhibits tnf-α-induced endothelial hyperpermeability of human aortic endothelial cells. | the increase in endothelial permeability often promotes edema formation in various pathological conditions. tumor necrosis factor-alpha (tnf-α), a pro-atherogenic cytokine, impairs endothelial barrier function and causes endothelial dysfunction in early stage of atherosclerosis. asiaticoside, one of the triterpenoids derived from centella asiatica, is known to possess antiinflammatory activity. in order to examine the role of asiaticoside in preserving the endothelial barrier, we assessed its ef ... | 2015 | 26171791 |
| synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: structure/activity studies. | fibrotic diseases are characterized by the over-accumulation of fibrous components in the extracellular matrix and the liver, which can lead to liver cirrhosis. current treatment options cannot reverse or halt liver fibrosis, motivating a search for newer treatment options. previously, we showed that asiaticoside, a bioactive triterpene glycoside from centella asiatica, has anti-fibrotic properties. here, the aglycone asiatic acid was chemically modified, and these derivatives were evaluated for ... | 2015 | 25461275 |
| an ethnobotanical study of medicinal plants in palamalai region of eastern ghats, india. | during the last few decades there has been an increasing interest in the study of medicinal plants with their traditional use and related pharmacological research all over the world. this paper enumerated folk medicinal plants used by malayali tribal people in an unexplored and biodiversity rich region of eastern ghats in southern india. | 2015 | 26068426 |
| centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. | diabetes mellitus is associated with inflammatory endothelial activation and increased vascular leukocyte adhesion molecule expression, both playing a prominent role in the development of vascular complications. centella asiatica (ca) and lipoic acid (la) have shown anti-inflammatory and anti-oxidant properties in a variety of experimental models; however, their action on human umbilical vein endothelial cells (huvecs), chronically exposed to hyperglycemia and pro-inflammatory environment during ... | 2015 | 26026207 |
| mechanical properties and in vivo healing evaluation of a novel centella asiatica-loaded hydrocolloid wound dressing. | to develop a novel sodium alginate based centella asiatica (ca)-loaded hydrocolloid wound dressing (hcd) providing excellent mechanical properties and improved wound healing, numerous ca-loaded hcds were prepared with various ingredients using the hot melting method. the effect of sodium alginate, styrene-isoprene-styrene copolymer (sis) and petroleum hydrocarbon resin (phr) on the mechanical properties of ca-loaded hcds was investigated. the effect of disintegrants on swelling and drug release ... | 2015 | 26024819 |
| evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from gotu kola or centella asiatica, in the male sprague dawley rat. | herbal medication use continues to rise and interactions with existing medications propose risks and may have significant effects and consequences on the administration of anesthesia. the purpose of this study was to investigate the anxiolytic and antidepressant effects of asiatic acid and its potential modulation of the γ-aminobutyric acid (gabaa) receptor. fifty-five male sprague dawley rats were divided into 5 groups: vehicle (dmso), asiatic acid (aa), midazolam, or a combination of flumazeni ... | 2015 | 26016167 |
| in vitro assessment of cyp1a2 and 2c9 inhibition potential of withania somnifera and centella asiatica in human liver microsomes. | several herbal drugs and allopathic medicines when co-administered can lead to severe herb-drug interactions. hence, this study was undertaken in order to assess the in vitro inhibition potential of withania somnifera and centella asiatica with cytochrome p450 (cyp) 1a2 and 2c9 enzyme using human liver microsomes. | 2015 | 25938222 |
| prophylactic effects of asiaticoside-based standardized extract of centella asiatica (l.) urban leaves on experimental migraine: involvement of 5ht1a/1b receptors. | the present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside (as) based standardized extract of centella asiatica (l.) urban leaves (indca) in animal models of migraine. the effects of oral and intranasal (i.n.) pretreatment of indca (acute and 7-days subacute) were evaluated against nitroglycerine (ntg, 10 mg·kg(-1), i.p.) and bradykinin (bk, 10 μg, intra-arterial) induced hyperalgesia in rats. tail flick latencies (from 0 to 240 min) post-ntg treatment ... | 2015 | 25908624 |
| centella asiatica and its fractions reduces lipid peroxidation induced by quinolinic acid and sodium nitroprusside in rat brain regions. | oxidative stress has been implicated in several pathologies including neurological disorders. centella asiatica is a popular medicinal plant which has long been used to treat neurological disturbances in ayurvedic medicine. in the present study, we quantified of compounds by high performance liquid chromatography (hplc) and examined the phenolic content of infusion, ethyl acetate, n-butanolic and dichloromethane fractions. furthermore, we analyzed the ability of the extracts from c. asiatica to ... | 2015 | 25903808 |
| dynamics of flavonol accumulation in leaf tissues under different uv-b regimes in centella asiatica (apiaceae). | a cumulative effect of uv-b doses on epidermal flavonol accumulation was observed during the first week of a time course study in centella asiatica (apiaceae). however, once flavonol levels had peaked, additional accumulation was possible only if higher daily uv-b irradiances were applied. we aimed to understand the dynamics of flavonol accumulation in leaf tissues using non-destructive spectroscopy and hplc-mass spectrometry. when leaves that had grown without uv-b were given brief daily exposu ... | 2015 | 25896373 |
| synthetic and natural inhibitors of phospholipases a2: their importance for understanding and treatment of neurological disorders. | phospholipases a2 (pla2) are a diverse group of enzymes that hydrolyze membrane phospholipids into arachidonic acid and lysophospholipids. arachidonic acid is metabolized to eicosanoids (prostaglandins, leukotrienes, thromboxanes), and lysophospholipids are converted to platelet-activating factors. these lipid mediators play critical roles in the initiation, maintenance, and modulation of neuroinflammation and oxidative stress. neurological disorders including excitotoxicity; traumatic nerve and ... | 2015 | 25891385 |
| a molecular docking study of phytochemical estrogen mimics from dietary herbal supplements. | the purpose of this study is to use a molecular docking approach to identify potential estrogen mimics or anti-estrogens in phytochemicals found in popular dietary herbal supplements. | 2015 | 25878948 |
| asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of nf-κb signaling pathway. | asiaticoside (as), a triterpene glycoside isolated from centella asiatica, has been shown to possess potent anti-inflammatory activity. however, the detailed molecular mechanisms of as on lipopolysaccharide (lps)-induced acute lung injury (ali) model in mice are scanty. the purpose of this study was to evaluate the effect of as on lps-induced mouse ali via down-regulation of nf-κb signaling pathway. we investigated the efficacy of as on cytokine levels induced by lps in bronchoalveolar lavage fl ... | 2015 | 25835778 |
| herbal supplements and hepatotoxicity: a short review. | herbal products have gained popularity over the past few decades. the reasons attributed to the rise in popularity are cheaper costs, easy availability, patient compliance and fewer side effects. however, liver toxicity following consumption of herbal remedies is on the increase. thus, there is an urgent need to understand the mechanism of action of the herbal supplements on the liver. occasionally, herbal supplements may also interact with conventional drugs. the present review focusses on a fe ... | 2015 | 26669124 |
| asiatic acid attenuates the progression of left ventricular hypertrophy and heart failure induced by pressure overload by inhibiting myocardial remodeling in mice. | cardiac structural remodeling, including cardiomyocyte apoptosis, interstitial fibrosis, and inflammation, appears to be a key event associated with the progression of left ventricular hypertrophy and heart failure. asiatic acid (aa) is a triterpenoid compound extracted from centella asiatica that exhibits antiapoptotic, antifibrotic, and anti-inflammatory activities. in the present study, a transverse aortic constriction (tac) model was created in mice to mimic the progression of hypertrophy (2 ... | 2015 | 26647013 |
| treatment of renal fibrosis by rebalancing tgf-β/smad signaling with the combination of asiatic acid and naringenin. | we recently showed that imbalance of tgf-β/smad signaling with over-activation of smad3 but lower levels of smad7 is a central mechanism of tissue fibrosis. in the present study, we report here that inhibition of smad3 with naringenin (ng) and upregulation of smad7 with asiatic acid (aa) produced an additive effect on inhibition of renal fibrosis in a mouse model of obstructive nephropathy. we found that aa, a triterpene from centella asiatica, functioned as a smad7 agonist and suppressed tgf-β/ ... | 2015 | 26474462 |
| nerve protective effect of asiaticoside against ischemia-hypoxia in cultured rat cortex neurons. | asiaticoside is one of the main functional components of the natural plant centella asiatica urban. studies have reported it has several functions such as anti-depression and nerve cell protection. asiaticoside can reduce the cerebral infarct size in acute focal cerebral ischemia in a mouse model and asiatic acid glycosides can significantly improve neurobehavioral scores. currently, there is a lack of understanding of asiaticoside in regard to its neural protective mechanism in cerebral ischemi ... | 2015 | 26447863 |
| effects of asiatic acid on spatial working memory and cell proliferation in the adult rat hippocampus. | asiatic acid is a pentacyclic triterpene from centella asiatica. previous studies have reported that asiatic acid exhibits antioxidant and neuroprotective activities in cell culture. it also prevents memory deficits in animal models. the objective of this study was to investigate the relationship between spatial working memory and changes in cell proliferation within the hippocampus after administration of asiatic acid to male spraque-dawley rats. control rats received vehicle (propylene glycol) ... | 2015 | 26445061 |
| molecular cloning, characterization and expression analysis of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from centella asiatica l. | 3-hydroxy-3-methylglutaryl-coa reductases (hmgr) plays an important role in catalyzing the first committed step of isoprenoid biosynthesis in the mevelonic (mva) pathway (catalyzes the conversion of hmg-coa to mva) in plants. the present manuscript reports the full length cdna cloning of hmgr (cahmgr, genbank accession number: kj939450.2) and its characterization from centella asiatica. sequence analysis indicated that the cdna was of 1965 bp, which had an open reading frame of 1617 bp and encod ... | 2015 | 26311154 |