| in vitro interactions between probiotic bacteria and milk proteins probed by atomic force microscopy. | interactions between microbial cells and milk proteins are important for cell location into dairy matrices. in this study, interactions between two probiotic strains, lactobacillus rhamnosus gg and lactobacillus rhamnosus gr-1, and milk proteins (micellar casein, native and denatured whey proteins) were studied. the bacterial surface characterization was realized with x-ray photoelectron spectroscopy (xps) to evaluate surface composition (in terms of proteins, polysaccharides and lipid-like comp ... | 2012 | 23298601 |
| lactobacillus rhamnosus (lgg) regulates il-10 signaling in the developing murine colon through upregulation of the il-10r2 receptor subunit. | the intestinal microflora is critical for normal development, with aberrant colonization increasing the risk for necrotizing enterocolitis (nec). in contrast, probiotic bacteria have been shown to decrease its incidence. multiple pro- and anti-inflammatory cytokines have been identified as markers of intestinal inflammation, both in human patients with nec and in models of immature intestine. specifically, il-10 signaling attenuates intestinal responses to gut dysbiosis, and disruption of this p ... | 2012 | 23272193 |
| nasally administered lactobacillus rhamnosus accelerate the recovery of humoral immunity in b lymphocyte-deficient malnourished mice. | the ability of nasally administered lactobacillus rhamnosus crl1505 to accelerate the recovery of respiratory b cell-mediated immunity against pneumococcal infection in replete malnourished mice was evaluated. weaned mice were malnourished after consumption of a protein-free diet for 21 d. malnourished mice were fed a balanced conventional diet (bcd) for 7 d (bcd group) or a bcd for 7 d with supplemental l. rhamnosus crl1505 by the nasal route during the last 2 d (bcd+lr group). nonreplete malno ... | 2012 | 23269656 |
| probiotic lactobacillus rhamnosus gg modulates the mucosal immune response in giardia intestinalis-infected balb/c mice. | gut homeostasis can be altered by the oral administration of health-promoting microorganisms, namely probiotics that are known to reinforce the host immune response. | 2012 | 23263901 |
| preferential production of g-csf by a protein-like lactobacillus rhamnosus gr-1 secretory factor through activating tlr2-dependent signaling events without activation of jnks. | different species and strains of probiotic bacteria confer distinct immunological responses on immune cells. lactobacillus rhamnosus gr-1 (gr-1) is a probiotic bacterial strain found in both the intestinal and urogenital tracts, and has immunomodulatory effects on several cell types including macrophages. however, detailed immunological responses and the signaling mechanism involved in the response are largely unknown. | 2015 | 26502905 |
| bugs that debugs: probiotics. | the oral cavity harbors a diverse array of bacterial species. there are more than 600 species that colonize in the oral cavity. these include a lot of organisms that are not commonly known to reside in the gastrointestinal (gi) tract and also are more familiar: lactobacillus acidophilus, lactobacillus casei, lactobacillus fermentum, lactobacillus plantarum, lactobacillus rhamnosus, and lactobacillus salivarius. the balance of all these microorganisms can easily be disturbed and a prevalence of p ... | 2012 | 23066281 |
| management strategies in the treatment of neonatal and pediatric gastroenteritis. | acute gastroenteritis, characterized by the onset of diarrhea with or without vomiting, continues to be a major cause of morbidity and mortality in children in mostly resource-constrained nations. although generally a mild and self-limiting disease, gastroenteritis is one of the most common causes of hospitalization and is associated with a substantial disease burden. worldwide, up to 40% of children aged less than 5 years with diarrhea are hospitalized with rotavirus. also, some microorganisms ... | 2013 | 24194646 |
| a network-based approach to identify substrate classes of bacterial glycosyltransferases. | bacterial interactions with the environment- and/or host largely depend on the bacterial glycome. the specificities of a bacterial glycome are largely determined by glycosyltransferases (gts), the enzymes involved in transferring sugar moieties from an activated donor to a specific substrate. of these gts their coding regions, but mainly also their substrate specificity are still largely unannotated as most sequence-based annotation flows suffer from the lack of characterized sequence motifs tha ... | 2014 | 24885406 |
| an l-fucose operon in the probiotic lactobacillus rhamnosus gg is involved in adaptation to gastrointestinal conditions. | l-fucose is a sugar present in human secretions as part of human milk oligosaccharides, mucins, and other glycoconjugates in the intestinal epithelium. the genome of the probiotic lactobacillus rhamnosus gg (lgg) carries a gene cluster encoding a putative l-fucose permease (fucp), l-fucose catabolic pathway (fuci, fuck, fucu, and fuca), and a transcriptional regulator (fucr). the metabolism of l-fucose in lgg results in 1,2-propanediol production, and their fuci and fucp mutants displayed a seve ... | 2015 | 25819967 |
| molecular cloning, expression of mind gene from lactobacillus acidophilus vtcc-b-871 and analyses to identify lactobacillus rhamnosus pn04 from vietnam hottuynia cordata thunb. | the mind gene encoding an inhibitor cell division mind homolog from lactobacillus acidophilus vtcc-b-871 was cloned. we showed that there were 97 % homology between mind genes of l. acidophilus vtcc-b-871 and lactobacillus rhamnosus gg and lactobacillus rhamnosus lc705. based on the analysis of the dna sequence data from the l. rhamnosus genome project and sequenced mind gene of l. acidophilus vtcc-b-871, a pair of primers was designed to identified the different mind genes from l. acidophilus a ... | 2013 | 24426140 |
| discovery of novel small molecule modulators of clavibacter michiganensis subsp. michiganensis. | clavibacter michiganensis subsp. michiganensis (cmm) is a gram-positive seed-transmitted bacterial phytopathogen responsible for substantial economic losses by adversely affecting tomato production worldwide. a high-throughput, cell-based screen was adapted to identify novel small molecule growth inhibitors to serve as leads for future bactericide development. a library of 4,182 compounds known to be bioactive against saccharomyces cerevisiae was selected for primary screening against cmm wild-t ... | 2015 | 26539169 |
| production of bacteriocin-like substances by lactic acid bacteria isolated from regional ovine cheese. | lactic acid bacteria (lab) were isolated from ovine milk and cheeses manufactured in the south region of brazil. among 112 bacterial isolates investigated, 59 were chosen through a screening for lab. among these 59 strains of lab, 21% showed antimicrobial, proteolytic and lipolytic activities. based on this screening, lactobacillus plantarum lcn 17 and lactobacillus rhamnosus lcn 43 were selected and tested for the production of bacteriocin-like substances (bls). the bls produced by both isolate ... | 2010 | 24031581 |
| benzoic acid production with respect to starter culture and incubation temperature during yogurt fermentation using response surface methodology. | benzoic acid is occasionally used as a raw material supplement in food products and is sometimes generated during the fermentation process. in this study, the production of naturally occurring yogurt preservatives was investigated for various starter cultures and incubation temperatures, and considered food regulations. streptococcus thermophilus, lactobacillus acidophilus, lactobacillus delbrueckii subsp. bulgaricus, lactobacillus rhamnosus, lactobacillus casei, lactobacillus paracasei, lactoba ... | 2016 | 27433115 |
| unique secreted-surface protein complex of lactobacillus rhamnosus, identified by phage display. | proteins are the most diverse structures on bacterial surfaces; hence, they are candidates for species- and strain-specific interactions of bacteria with the host, environment, and other microorganisms. genomics has decoded thousands of bacterial surface and secreted proteins, yet the function of most cannot be predicted because of the enormous variability and a lack of experimental data that would allow deduction of function through homology. here, we used phage display to identify a pair of in ... | 2012 | 23233310 |
| phylogenetic analysis of a spontaneous cocoa bean fermentation metagenome reveals new insights into its bacterial and fungal community diversity. | this is the first report on the phylogenetic analysis of the community diversity of a single spontaneous cocoa bean box fermentation sample through a metagenomic approach involving 454 pyrosequencing. several sequence-based and composition-based taxonomic profiling tools were used and evaluated to avoid software-dependent results and their outcome was validated by comparison with previously obtained culture-dependent and culture-independent data. overall, this approach revealed a wider bacterial ... | 2012 | 22666442 |
| antimicrobial and antibiofilm potential of biosurfactants isolated from lactobacilli against multi-drug-resistant pathogens. | biosurfactants (bs) are amphiphilic compounds produced by microbes, either on the cell surface or secreted extracellularly. bs exhibit strong antimicrobial and anti-adhesive properties, making them good candidates for applications used to combat infections. in this study, our goal was to assess the in vitro antimicrobial, anti-adhesive and anti-biofilm abilities of bs produced by lactobacillus jensenii and lactobacillus rhamnosus against clinical multidrug resistant (mdr) strains of acinetobacte ... | 2014 | 25124936 |
| pantoea agglomerans in immunodeficient patients with different respiratory symptoms. | the aim of this paper was to determine in 32 patients from 4 different mexican hospitals the frequency of opportunistic bacteria in the 2010 to 2011 time period. the patients were divided in 4 groups. group 1 included 21 hiv positive patients with acute respiratory syndrome. four hiv positive patients with tuberculosis symptoms were included in group 2; two patients with tuberculosis symptoms and one asymptomatic person formed group 3. reference group 4 included 4 patients from whom 4 strains of ... | 2012 | 22619600 |
| molecular analysis and clinical significance of lactobacillus spp. recovered from clinical specimens presumptively associated with disease. | lactobacillus spp. are part of the normal human flora and are generally assumed to be nonpathogenic. we determined the genotypic identification of >100 lactobacillus isolates from clinical specimens in the context of presumed pathogenic potential (e.g., recovered as the single/predominant isolate from a sterile site or at ≥10(5) cfu/ml from urine). this study assessed the clinical significance and the frequency of occurrence of each lactobacillus sp. we identified 16 species of lactobacillus by ... | 2014 | 24131686 |
| high protective efficacy of probiotics and rice bran against human norovirus infection and diarrhea in gnotobiotic pigs. | probiotics have been recognized as vaccine adjuvants and therapeutic agents to treat acute gastroenteritis in children. we previously showed that rice bran (rb) reduced human rotavirus diarrhea in gnotobiotic pigs. human noroviruses (hunovs) are the major pathogens causing non-bacterial acute gastroenteritis worldwide. in this study, lactobacillus rhamnosus gg (lgg) and escherichia coli nissle 1917 (ecn) were first screened for their ability to bind hunov p particles and virions derived from cli ... | 2016 | 27853451 |
| modulation of respiratory tlr3-anti-viral response by probiotic microorganisms: lessons learned from lactobacillus rhamnosus crl1505. | respiratory syncytial virus (rsv) is the leading cause of lower respiratory tract illness in infants and young children. host immune response is implicated in both protective and immunopathological mechanisms during rsv infection. activation of toll-like receptor (tlr)-3 in innate immune cells by rsv can induce airway inflammation, protective immune response, and pulmonary immunopathology. a clear understanding of rsv-host interaction is important for the development of novel and effective thera ... | 2014 | 24860569 |
| in vivo gut transcriptome responses to lactobacillus rhamnosus gg and lactobacillus acidophilus in neonatal gnotobiotic piglets. | probiotics facilitate mucosal repair and maintain gut homeostasis. they are often used in adjunct with rehydration or antibiotic therapy in enteric infections. lactobacillus spp have been tested in infants for the prevention or treatment of various enteric conditions. however, to aid in rational strain selection for specific treatments, comprehensive studies are required to delineate and compare the specific molecules and pathways involved in a less complex but biologically relevant model (gnoto ... | 2014 | 24637605 |
| probiotic lactobacillus rhamnosus gg enhanced th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model. | this study aims to establish a human gut microbiota (hgm) transplanted gnotobiotic (gn) pig model of human rotavirus (hrv) infection and diarrhea, and to verify the dose-effects of probiotics on hrv vaccine-induced immune responses. our previous studies using the gn pig model found that probiotics dose-dependently regulated both t cell and b cell immune responses induced by rotavirus vaccines. we generated the hgm transplanted neonatal gn pigs through daily feeding of neonatal human fecal suspen ... | 2014 | 24722168 |
| optimization performance of an ansbbr applied to biohydrogen production treating whey. | the present study investigated the influence of the influent concentration of substrate, feeding time and temperature on the production of biohydrogen from cheese whey in an ansbbr with liquid phase recirculation. the highest hydrogen yield (0.80 molh2.mollactose(-1)) and productivity (660 mlh2 l(-1) d(-1)) were achieved for influent concentrations of 5400 mgdqo l(-1). no significant difference was noted in the biological hydrogen production for the feeding time conditions analyzed. the lowest t ... | 2016 | 26751813 |
| antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries. | silver diamine fluoride (sdf) has clinical success in arresting dentin caries, this study aimed to investigate its mechanism of action. | 2013 | 23442825 |
| antimicrobial activity of different disinfectants against cariogenic microorganisms. | the aim of this study was to assess the in vitro antimicrobial effects of chlorhexidine digluconate (chx), polyhexamethylene biguanide (phbm), and octenidine dihydrochloride (oct) on cariogenic microorganisms by using their minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc). chx, phbm, and oct were diluted in distilled water to the final test concentrations. using the in-tube dilution method, streptococcus mutans, lactobacillus acidophilus, lactobacillus rhamnosu ... | 2016 | 27901206 |
| the effect of hydro alcoholic extract of seven plants on cariogenic bacteria--an in vitro evaluation. | to compare the antibacterial effect of hydro alcoholic extract of salvia officinalis, pimpinella anisum, satureja hortensis, rhus coriaria, carum copticum, mentha longifolia, achillea millefolium against streptococcus mutans, lactobacillus rhamnosus and actinomyces viscosus through two in vitro methods. | 2014 | 24984654 |
| interactions between lactobacillus rhamnosus gg and oral micro-organisms in an in vitro biofilm model. | probiotics have shown favourable properties in maintaining oral health. by interacting with oral microbial communities, these species could contribute to healthier microbial equilibrium. this study aimed to investigate in vitro the ability of probiotic lactobacillus rhamnosus gg (l.gg) to integrate in oral biofilm and affect its species composition. five oral strains, streptococcus mutans, streptococcus sanguinis, aggregatibacter actinomycetemcomitans, fusobacterium nucleatum and candida albican ... | 2016 | 27405227 |
| invited review: microbe-mediated aflatoxin decontamination of dairy products and feeds. | aspergillus flavus, aspergillus parasiticus, and aspergillus nomius contaminate corn, sorghum, rice, peanuts, tree nuts, figs, ginger, nutmeg, and milk. they produce aflatoxins, especially aflatoxin b1, which is classified as a group 1 carcinogen by the international agency for research on cancer. many studies have focused on aflatoxin removal from food or feed, especially via microbe-mediated mechanisms-either adsorption or degradation. of the lactic acid bacteria, lactobacillus rhamnosus gg ef ... | 2017 | 27939550 |
| the potential hazards of aspergillus sp. in foods and feeds, and the role of biological treatment: a review. | the contamination of food and feed by aspergillus has become a global issue with a significant worldwide economic impact. the growth of aspergillus is unfavourable to the development of food and feed industries, where the problems happen mostly due to the presence of mycotoxins, which is a toxic metabolite secreted by most aspergillus groups. moreover, fungi can produce spores that cause diseases, such as allergies and asthma, especially to human beings. high temperature, high moisture, retarded ... | 2014 | 25269603 |
| antifungal activity of lactobacilli and its relationship with 3-phenyllactic acid production. | in this study, 13 lactic acid bacteria (lab) strains (including 5 lactobacillus casei, 2 lactobacillus rhamnosus, 2 lactobacillus fermentum, 1 lactobacillus acidophilus, 1 lactobacillus plantarum, 1 lactobacillus sakei, and 1 lactobacillus reuteri species) were assessed for both their antifungal activity against four food spoilage molds (colletotrichum gloeosporioides, botrytis cinerea, penicillium expansum, and aspergillus flavus) and their capability to produce the novel antimicrobial compound ... | 2014 | 24412414 |
| inhibition of mycotoxin-producing aspergillus nomius vsc 23 by lactic acid bacteria and saccharomyces cerevisiae. | the effect of different fermenting microorganisms on growth of a mycotoxin- producing aspergillus nomius was assayed. two lactic acid bacteria, lactobacillus fermentum and lactobacillus rhamnosus, and saccharomyces cerevisiae, all of which are widely used in fermentation and preservation of food, were assayed on their fungus inhibitory properties. assays were carried out by simultaneous inoculation of one of the possible inhibiting microorganisms and the fungus or subsequent inoculation of one o ... | 2010 | 24031582 |
| bacteriocinogenic bacteria isolated from raw goat milk and goat cheese produced in the center of méxico. | currently, there are few reports on the isolation of microorganisms from goat milk and goat cheese that have antibacterial activity. in particular, there are no reports on the isolation of microorganisms with antibacterial activity from these products in central mexico. our objective was to isolate bacteria, from goat products, that synthesized antimicrobial peptides with activity against a variety of clinically significant bacteria. we isolated and identified lactobacillus rhamnosus, l. plantar ... | 2016 | 27407294 |
| effect of fermented broth from lactic acid bacteria on pathogenic bacteria proliferation. | in this study, the effect that 5 fermented broths of lactic acid bacteria (lab) strains have on the viability or proliferation and adhesion of 7 potentially pathogenic microorganisms was tested. the fermented broth from lactococcus lactis c660 had a growth inhibitory effect on escherichia coli k92 that reached of 31%, 19% to pseudomonas fluorescens, and 76% to staphylococcus epidermidis. the growth of staph. epidermidis was negatively affected to 90% by lc. lactis 11454 broth, whereas the growth ... | 2016 | 26851857 |
| inactivation of bacterial pathogens in yoba mutandabota, a dairy product fermented with the probiotic lactobacillus rhamnosus yoba. | mutandabota is a dairy product consumed as a major source of proteins and micronutrients in southern africa. in this study the microbial safety of traditional and a variant of mutandabota fermented with the probiotic lactobacillus rhamnosus yoba (yoba mutandabota) was investigated by challenging the products with five important food pathogens: listeria monocytogenes, salmonella spp., campylobacter jejuni, escherichia coli o157:h7 and bacillus cereus. pasteurized full-fat cow's milk was used for ... | 2016 | 26490648 |
| improved in vitro assay for determining the mucin adherence of bacteria sensitive to triton x-100 treatment. | mucin-associated microbiota are in relatively close contact with the intestinal epithelium and may thus have a more pronounced effect on host health. we have previously developed a simple mucin agar assay to simulate initial mucus colonization by intestinal microbial communities. adherence of microbiota was estimated using flow cytometry after detachment with triton x-100. in this study, the effect of this detergent on the cultivability of both virulent and commensal strains was investigated. mu ... | 2015 | 25702162 |
| the optimization of l-lactic acid production from sweet sorghum juice by mixed fermentation of bacillus coagulans and lactobacillus rhamnosus under unsterile conditions. | the cost reduction of raw material and sterilization could increase the economic feasibility of l-lactic acid fermentation, and the development of an cost-effective and efficient process is highly desired. to improve the efficiency of open fermentation by lactobacillus rhamnosus based on sweet sorghum juice (ssj) and to overcome sucrose utilization deficiency of bacillus coagulans, a mixed fermentation was developed. besides, the optimization of ph, sugar concentration and fermentation medium we ... | 2016 | 27469090 |
| effect of bacterial cell-free supernatants on infectivity of norovirus surrogates. | bacterial metabolic products were evaluated for inhibitory effects on viral propagation in cell culture. cell-free supernatants (cfs) were prepared from growth of enterococcus faecalis atcc 19433, pseudomonas fluorescens atcc 13525, escherichia coli 08, staphylococcus epidermidis atcc 12228, bacillus subtilis 168, bacillus coagulans 185a, b. coagulans 7050, clostridium sporogenes pa3679, and a commercial probiotic mixture of lactobacillus acidophilus, lactobacillus rhamnosus, bifidobacterium bif ... | 2014 | 24406013 |
| bacillus licheniformis isolated from traditional korean food resources enhances the longevity of caenorhabditis elegans through serotonin signaling. | in this study, we investigated potentially probiotic bacillus licheniformis strains isolated from traditional korean food sources for ability to enhance longevity using the nematode caenorhabditis elegans as a simple in vivo animal model. we first investigated whether b. licheniformis strains were capable of modulating the lifespan of c. elegans. among the tested strains, preconditioning with four b. licheniformis strains significantly enhanced the longevity of c. elegans. unexpectedly, plate co ... | 2015 | 26541069 |
| characterization of engineered preq1 riboswitches for inducible gene regulation in mycobacteria. | we report here the behavior of naturally occurring and rationally engineered preq1 riboswitches and their application to inducible gene regulation in mycobacteria. because mycobacteria lack preq1 biosynthetic genes, we hypothesized that preq1 could be used as an exogenous nonmetabolite ligand to control riboswitches in mycobacteria. selected naturally occurring preq1 riboswitches were assayed and successfully drove preq1-dependent repression of a green fluorescent protein reporter in mycobacteri ... | 2017 | 28069821 |
| purification and characterization of anti-alicyclobacillus bacteriocin produced by lactobacillus rhamnosus. | lactobacillus rhamnosus cicc 20975 produces a 6,502-da bacteriocin, named bacteriocin rc 20975, active against alicyclobacillus acidoterrestris, lactobacillus acidophilus, lactobacillus brevis, bacillus subtilis, and listeria innocua. this bacteriocin is not quite heat stable but is effective after refrigerated storage and freeze-thaw cycles. bacteriocin rc 20975 was added at a concentration of 256 au/ml to the endospores of a. acidoterrestris dsm 3922; no viable cells were detected after 24 h. ... | 2013 | 23992502 |
| effects of dietary supplementation of citrus by-products fermented with a probiotic microbe on growth performance, innate immunity and disease resistance against edwardsiella tarda in juvenile olive flounder, paralichthys olivaceus (temminck & schlegel). | two consecutive studies were conducted to evaluate the dietary supplementation of citrus by-products (cb) fermented with probiotic bacteria on growth performance, feed utilization, innate immune responses and disease resistance of juvenile olive flounder. in experiment i, five diets were formulated to contain 0% (control) or 3% four different cb fermented with bacillus subtilis (bs), enterococcus faecium (ef), lactobacillus rhamnosus (lr) and l. plantarum (lp) (designated as con, cbf-bs, cbf-ef, ... | 2013 | 23311661 |
| a microfluidics-based in vitro model of the gastrointestinal human-microbe interface. | changes in the human gastrointestinal microbiome are associated with several diseases. to infer causality, experiments in representative models are essential, but widely used animal models exhibit limitations. here we present a modular, microfluidics-based model (humix, human-microbial crosstalk), which allows co-culture of human and microbial cells under conditions representative of the gastrointestinal human-microbe interface. we demonstrate the ability of humix to recapitulate in vivo transcr ... | 2016 | 27168102 |
| bacteroides fragilis polysaccharide a is necessary and sufficient for acute activation of intestinal sensory neurons. | symbionts or probiotics are known to affect the nervous system. to understand the mechanisms involved, it is important to measure sensory neuron responses and identify molecules responsible for this interaction. here we test the effects of adding lactobacillus rhamnosus (jb-1) and bacteroides fragilis to the epithelium while making voltage recordings from intestinal primary afferent neurons. sensory responses are recorded within 8 s of applying jb-1 and excitability facilitated within 15 min. ba ... | 2013 | 23403566 |
| cell-free supernatants from probiotic lactobacillus casei and lactobacillus rhamnosus gg decrease colon cancer cell invasion in vitro. | probiotics have been shown to have a preventative role in colorectal carcinogenesis but research concerning their prophylactic potential in the later stages of colorectal cancer, specifically metastasis is limited. this study explored the potential of cell-free supernatants (cfs) from 2 probiotic lactobacillus sp., lactobacillus casei and lactobacillus rhamnosus gg, to inhibit colon cancer cell invasion by influencing matrix metalloproteinase-9 (mmp-9) activity and levels of the tight junction p ... | 2012 | 22830611 |
| cholesterol-lowering potentials of lactic acid bacteria based on bile-salt hydrolase activity and effect of potent strains on cholesterol metabolism in vitro and in vivo. | this study collected different probiotic isolates from animal and plant sources to evaluate the bile-salt hydrolase activity of probiotics in vitro. the deconjugation potential of bile acid was determined using high-performance liquid chromatography. hepg2 cells were cultured with probiotic strains with high bsh activity. the triglyceride (tg) and apolipoprotein b (apo b) secretion by hepg2 cells were evaluated. our results show that the bsh activity and bile-acid deconjugation abilities of pedi ... | 2014 | 25538960 |
| antibodies to lactobacilli and bifidobacteria in young children with different propensity to develop islet autoimmunity. | the intestinal microbiota is essential to the maturation and homeostasis of the immune system. immunoblot assays were used to establish the prevalence of serum igg, igm, and iga antibodies specific for bifidobacterium adolescentis, bifidobacterium longum, and lactobacillus rhamnosus gg proteins in young children presenting with or without type 1 diabetes (t1d). we demonstrated that children between the ages of 6 and 12 months had a substantial increase in the frequency of igg antibodies specific ... | 2014 | 24741589 |
| genotoxicity assessment of multispecies probiotics using reverse mutation, mammalian chromosomal aberration, and rodent micronucleus tests. | genotoxicity assessment is carried out on freeze dried powder of cultured probiotics containing lactobacillus rhamnosus lcr177, bifidobacterium adolescentis ba286, and pediococcus acidilactici pa318. ames tests, in vitro mammalian chromosome aberration assay, and micronucleus tests in mouse peripheral blood are performed. for 5 strains of salmonella typhimurium, the ames tests show no increased reverse mutation upon exposure to the test substance. in cho cells, the frequency of chromosome aberra ... | 2013 | 24250262 |
| reduced th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. | in the randomized, controlled study probiotics in the prevention of allergy among children in trondheim (propact), maternal probiotic supplementation reduced the incidence of atopic dermatitis (ad) in the offspring. in the current study, we hypothesized that the effect was mediated by a shift in the t helper (th) cells in the children. | 2017 | 28346719 |
| selective method for identification and quantification of bifidobacterium animalis subspecies lactis bb-12 (bb-12) from the gastrointestinal tract of healthy volunteers ingesting a combination probiotic of bb-12 and lactobacillus rhamnosus gg. | to develop a novel validated method for the isolation of bifidobacterium animalis ssp. lactis bb-12 (bb-12) from faecal specimens and apply it to studies of bb-12 and lactobacillus rhamnosus gg (lgg) recovered from the healthy human gastrointestinal (gi) tract. | 2017 | 28256070 |
| effect of probiotics on diarrhea in children with severe acute malnutrition: a randomized controlled study in uganda. | the aim of the study was to assess the effect of probiotics on diarrhea during in- and outpatient treatment of children with severe acute malnutrition (sam). | 2017 | 28079729 |
| orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. | the aim of this study was to evaluate in the vagina of 60 pre-menopausal women the detection of orally administered multispecies probiotic formulations showing anti-microbial properties in test in vitro. | 2017 | 27826653 |
| the different effects of probiotics treatment on salmonella-induced interleukin-8 response in intestinal epithelia cells via pi3k/akt and nod2 expression. | salmonella spp. remains a major public health problem for the whole world. intestinal epithelial cells serve as an essential component of the innate mucosal immune system to defend against salmonella infection. a substantial amount of evidence has accumulated that probiotics can regulate interleukin 8 (il-8) involved in innate immunity. however, the exact effect of probiotics on epithelial il-8 response to salmonella infection is not well understood. therefore, we investigated the action of prob ... | 2016 | 27680208 |
| probiotics and respiratory and gastrointestinal tract infections in finnish military conscripts - a randomised placebo-controlled double-blinded study. | military conscripts are susceptible to respiratory and gastrointestinal tract infections. in previous studies probiotics have shown potency to reduce upper respiratory and gastrointestinal infections. the aim was to study whether probiotic intervention has an impact on seasonal occurrence of upper respiratory and gastrointestinal infections in two different conscript groups. in a randomised, double-blinded, placebo controlled study (https://clinicaltrials.gov nct01651195), a total of 983 healthy ... | 2016 | 27048835 |
| supplementation of xylitol-containing chewing gum with probiotics: a double blind, randomised pilot study focusing on saliva flow and saliva properties. | the aim of this study was to investigate the impact of daily chewing, for 12 weeks, of 2 different probiotic gums compared with placebo on saliva flow rate, saliva iga levels and saliva ph. the intervention study included 54 adult volunteers with hyposalivation in a double-blind, randomised and placebo-controlled design with three parallel groups. volunteers were randomly assigned to 3 different groups: subjects in group a (n = 19) were given placebo chewing gum, group b (n = 17) received bifido ... | 2016 | 26913493 |
| microencapsulation of new probiotic formulations for gastrointestinal delivery: in vitro study to assess viability and biological properties. | the paper describes the preparation of new probiotic formulations based on chitosan-coated alginate microcapsules containing three different probiotic strains, lactobacillus plantarum pbs067, lactobacillus rhamnosus pbs070, and bifidobacterium animalis subsp. lactis pbs075 taken individually and as a mixture of them. the effects of microencapsulation on the viability of the strains in conditions simulating the gastrointestinal tract and under industrial processes conditions were studied. in addi ... | 2015 | 26239070 |
| immunomodulatory effects of probiotic supplementation in schizophrenia patients: a randomized, placebo-controlled trial. | although peripheral immune system abnormalities have been linked to schizophrenia pathophysiology, standard antipsychotic drugs show limited immunological effects. thus, more effective treatment approaches are required. probiotics are microorganisms that modulate the immune response of the host and, therefore, may be beneficial to schizophrenia patients. the aim of this study was to examine the possible immunomodulatory effects of probiotic supplementation in chronic schizophrenia patients. the ... | 2015 | 26052224 |
| effect of sublethal preculturing on the survival of probiotics and metabolite formation in set-yoghurt. | the objective of this study was to investigate the effect of preculturing of lactobacillus rhamnosus gg and bifidobacterium animalis subsp. lactis bb12 under sublethal stress conditions on their survival and metabolite formation in set-yoghurt. prior to co-cultivation with yoghurt starters in milk, the two probiotic strains were precultured under sublethal stress conditions (combinations of elevated nacl and low ph) in a batch fermentor. the activity of sublethally precultured probiotics was eva ... | 2015 | 25846920 |
| does maternal perinatal probiotic supplementation alter the intestinal microbiota of mother and child? | maternal probiotic supplementation has been shown to prevent the development of atopic dermatitis in the offspring. we aimed to investigate whether probiotics in pregnant and breast-feeding mothers altered the colonization pattern and the diversity of the mothers' and children's intestinal microbiota. | 2015 | 25782657 |
| differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to toll-like receptors. | there is strong evidence to support a genetic predisposition to eczema and more recently studies have suggested that probiotics might be used to prevent eczema by modifying the expression of putative allergy-associated genes. the aim of this present study was to investigate whether two probiotics, lactobacillus rhamnosus hn001 (hn001) and bifidobacterium animalis subsp. lactis hn019 (hn019), can modify the known genetic predisposition to eczema conferred by genetic variation in the toll-like rec ... | 2015 | 25779902 |
| evaluation of the probiotic properties of new lactobacillus and bifidobacterium strains and their in vitro effect. | probiotic ingestion is recommended as a preventive approach to maintain the balance of the intestinal microbiota and to enhance the human well-being. during the whole life of each individual, the gut microbiota composition could be altered by lifestyle, diet, antibiotic therapies and other stress conditions, which may lead to acute and chronic disorders. hence, probiotics can be administered for the prevention or treatment of some disorders, including lactose malabsorption, acute diarrhoea, irri ... | 2015 | 25744647 |
| lactobacilli and bifidobacteria enhance mucosal b cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model. | b cells play a key role in generation of protective immunity against rotavirus infection, a major cause of gastroenteritis in children. current rv vaccines are less effective in developing countries compared to developed countries. commensals/probiotics influence mucosal immunity, but the role of early gut colonizing bacteria in modulating intestinal b cell responses to rv vaccines is largely unknown. we co-colonized neonatal gnotobiotic pigs, the only animal model susceptible to hrv diarrhea, w ... | 2014 | 25483333 |
| differential modification of genetic susceptibility to childhood eczema by two probiotics. | in a double-blind, randomized, placebo-controlled birth cohort, we have recently shown a beneficial effect of lactobacillus rhamnosus hn001 (hn001) for the prevention of eczema in children through to 6 years of age but no effect of bifidobacterium animalis subsp lactis hn019 (hn019). | 2014 | 25146491 |
| effect of probiotic supplementation on schizophrenia symptoms and association with gastrointestinal functioning: a randomized, placebo-controlled trial. | a range of immune system abnormalities have been associated with schizophrenia. probiotic compounds modulate the immune response and offer a potential treatment strategy for schizophrenia. probiotic compounds have also been observed to improve gastrointestinal dysfunction, which is a common problem in individuals with schizophrenia. we performed a randomized, double-blind, placebo-controlled trial to examine whether probiotic supplementation can reduce symptom severity in patients with schizophr ... | 2014 | 24940526 |
| specific probiotics and virological findings in symptomatic conscripts attending military service in finland. | viral upper respiratory tract infections occur frequently among conscripts. probiotics have reduced viral infections in children attending day care. limited data are available on the effects of probiotics on the nasopharyngeal presence of respiratory viruses. | 2014 | 24793963 |
| assessment of stress tolerance acquisition in the heat-tolerant derivative strains of bifidobacterium animalis subsp. lactis bb-12 and lactobacillus rhamnosus gg. | the purpose of this study was to investigate the heat-shock response at molecular level in lactobacillus rhamnosus gg, bifidobacterium animalis subsp. lactis bb-12 and their heat-tolerant derivatives and to characterize the changes that make the derivatives more robust in terms of heat stress. | 2014 | 24724909 |
| impact of orally administered lozenges with lactobacillus rhamnosus gg and bifidobacterium animalis subsp. lactis bb-12 on the number of salivary mutans streptococci, amount of plaque, gingival inflammation and the oral microbiome in healthy adults. | the aim was to evaluate the effects of orally administered lactobacillus rhamnosus gg (lgg) and bifidobacterium animalis subsp. lactis bb-12 (bb-12) on the number of salivary mutans streptococci (ms), amount of plaque, gingival inflammation and the oral microbiota in healthy young adults. | 2015 | 24638207 |
| immune system stimulation by probiotic microorganisms. | probiotic organisms are claimed to offer several functional properties including stimulation of immune system. this review is presented to provide detailed informations about how probiotics stimulate our immune system. lactobacillus rhamnosus gg, lactobacillus casei shirota, bifidobacterium animalis bb-12, lactobacillus johnsonii la1, bifidobacterium lactis dr10, and saccharomyces cerevisiae boulardii are the most investigated probiotic cultures for their immunomodulation properties. probiotics ... | 2014 | 24499072 |
| effect of prebiotic carbohydrates on growth, bile survival and cholesterol uptake abilities of dairy-related bacteria. | three strains of lactic acid bacteria and one probiotic bifidobacterium strain sourced from milk origin were considered to select for the best synbiotic-like combination for cholesterol uptake ability. for that purpose, fermentative characteristics, bile salt hydrolase activity, bile survival and cholesterol removal were assessed in the presence of different carbohydrates. | 2014 | 24037813 |
| early supplementation with lactobacillus rhamnosus hn001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization? | the role of probiotics in prevention of allergic disease is still not clear; efficacy may depend on the timing, dose, duration, and specific probiotic used. using a double-blind randomized placebo-controlled trial (australian new zealand clinical trials registry: actrn12607000518460), we have shown that in a high-risk birth cohort, maternal supplementation from 35 weeks gestation until 6 months if breastfeeding and infant supplementation from birth until 2 years with lactobacillus rhamnosus hn00 ... | 2013 | 23957340 |
| assessment of the effect of stress-tolerance acquisition on some basic characteristics of specific probiotics. | the production of viable functional probiotics presupposes stability of strain features in the final product. we evaluated the impact of acquisition of heat-tolerance and subsequent freeze-drying on the adhesion properties of lactobacillus rhamnosus gg, lactobacillus casei shirota, bifidobacterium lactis bb-12 and bifidobacterium animalis if20/1 and on their ability to inhibit the adhesion of pathogens in a mucus model. both fresh and freeze-dried cultures were evaluated. significant differences ... | 2013 | 23688551 |
| in vitro inhibition of clostridium difficile and clostridium perfringens by commercial probiotic strains. | probiotics have gained importance in human and veterinary medicine to prevent and control clostridial enteric disease. limited information is available on the ability of different probiotic bacteria used in food products to inhibit clostridium difficile and clostridium perfringens. the objective of this study was to examine the in vitro inhibitory effects of selected commercial bacterial strains on pathogenic clostridia and their growth characteristics under simulated gastrointestinal conditions ... | 2013 | 23471038 |
| assessment of probiotic viability during cheddar cheese manufacture and ripening using propidium monoazide-pcr quantification. | the use of a suitable food carrier such as cheese could significantly enhance probiotic viability during storage. the main goal of this study was to assess viability of commercial probiotic strains during cheddar cheesemaking and ripening (4-6 months) by comparing the efficiency of microbiological and molecular approaches. molecular methods such as quantitative pcr (qpcr) allow bacterial quantification, and dna-blocking molecules such as propidium monoazide (pma) select only the living cells' dn ... | 2012 | 23060868 |
| effect of lactobacillus rhamnosus lgg® and bifidobacterium animalis ssp. lactis bb-12® on health-related quality of life in college students affected by upper respiratory infections. | college students are susceptible to upper respiratory infections (uri) due to inadequate sleep, stress and close living quarters. certain probiotic strains modulate immune function and may improve health-related quality of life (hrql) during uri. the present study recruited apparently healthy college students and assessed the effect of probiotics on hrql outcomes (i.e. self-reported duration, symptom severity and functional impairment of uri) in those who developed uri. missed school and work da ... | 2013 | 23020819 |
| myosin-cross-reactive antigens from four different lactic acid bacteria are fatty acid hydratases. | the 67 kda myosin-cross-reactive antigen (mcra) is a member of the mcra family of proteins present in a wide range of bacteria and was predicted to have fatty acid isomerase function. we have now characterised the catalytic activity of mcras from four lab stains, including lactobacillus rhamnosus lgg, l. plantarum st-iii, l. acidophilus ncfm and bifidobacterium animalis subsp. lactis bb-12. mcra genes from these strains were cloned and expressed in escherichia coli, and the recombinant protein f ... | 2013 | 22955678 |
| a protective effect of lactobacillus rhamnosus hn001 against eczema in the first 2 years of life persists to age 4 years. | using a double blind randomized placebo-controlled trial (australian new zealand clinical trials registry: actrn12607000518460), we have shown that in a high risk birth cohort, maternal supplementation from 35 weeks gestation until 6 months if breastfeeding and infant supplementation until 2 years with lactobacillus rhamnosus hn001 (hn001) (6 × 10(9) cfu/day) halved the cumulative prevalence of eczema by age 2 years. bifidobacterium animalis subsp lactis hn019 (hn019) (9 × 10(9) cfu/day) had no ... | 2012 | 22702506 |
| gut balance, a synbiotic supplement, increases fecal lactobacillus paracasei but has little effect on immunity in healthy physically active individuals. | synbiotic supplements, which contain multiple functional ingredients, may enhance the immune system more than the use of individual ingredients alone. a double blind active controlled parallel trial over a 21 d exercise training period was conducted to evaluate the effect of gut balance™, which contains lactobacillus paracasei subsp. paracasei (l. casei 431®), bifidobacterium animalis ssp. lactis (bb-12®), lactobacillus acidophilus (la-5®), lactobacillus rhamnosus (lgg®), two prebiotics (raftili ... | 2017 | 22572834 |
| strain-specific probiotic properties of lactic acid bacteria and their interference with human intestinal pathogens invasion. | one of the working mechanisms of probiotic bacteria is their ability to compete with pathogens. to define the probiotic properties of seven lactic acid bacteria (lab) strains, we tested them for survival in simulated gastro-intestinal conditions, antimicrobial activities, co-aggregative abilities, and interferences studies against five human intestinal pathogens (salmonella enteritidis atcc 13076, listeria monocytogenes atcc 7644, escherichia coli o157: h7 atcc 35150, cronobacter sakazakii atcc ... | 2017 | 28286570 |
| effects of probiotics on nonalcoholic fatty liver disease in obese children and adolescents. | this study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease (nafld). | 2017 | 28230607 |
| a probiotic combination attenuates experimental colitis through inhibition of innate cytokine production. | inflammatory bowel disease (ibd) is a severe immune cell-mediated syndrome characterised by extensive inflammatory and effector mucosal responses leading to tissue destruction in the colon and small intestine. the leading hypothesis is that dysbiosis of the gut flora causes an excessive immune response and inflammation in the gastrointestinal track. lactic acid bacteria (lab) can correct dysbiosis of the normal microbiota. in the current study, the therapeutic potential of seven lab strains in c ... | 2016 | 28008786 |
| study on the influence of tea extract on probiotics in skim milk: from probiotics propagation to metabolite. | in this study, the influence of tea extract (te) on the growth of probiotics in skim milk was examined. lactobacillus plantarum st-iii, bifidobacterium bifidum bb02, lactobacillus acidophilus ncfm, and lactobacillus rhamnosus gg were used in this study. the introduction of te in milk significantly stimulated the propagation and acidification of l. rhamnosus gg and l. acidophilus ncfm. the antioxidant capacities and the total free amino acid contents of all fermented milk products were enhanced b ... | 2016 | 27384493 |
| lactobacillus rhamnosus gg increases toll-like receptor 3 gene expression in murine small intestine ex vivo and in vivo. | administration of lactobacillus rhamnosus gg (lgg) has been reported to be therapeutically effective against acute secretory diarrhoea resulting from the structural and functional intestinal mucosal lesions induced by rotavirus infection; however, the underlying mechanisms remain to be completely elucidated. because toll-like receptor 3 (tlr3) plays a key role in the innate immune responses following the recognition of rotavirus, the present study examined whether lgg influences tlr3 gene expres ... | 2016 | 27013459 |
| human gut-commensalic lactobacillus ruminis atcc 25644 displays sortase-assembled surface piliation: phenotypic characterization of its fimbrial operon through in silico predictive analysis and recombinant expression in lactococcus lactis. | sortase-dependent surface pili (or fimbriae) in gram-positive bacteria are well documented as a key virulence factor for certain harmful opportunistic pathogens. however, it is only recently known that these multi-subunit protein appendages are also belonging to the "friendly" commensals and now, with this new perspective, they have come to be categorized as a niche-adaptation factor as well. in this regard, it was shown earlier that sortase-assembled piliation is a native fixture of two human i ... | 2015 | 26709916 |
| perioperative synbiotics decrease postoperative complications in periampullary neoplasms: a randomized, double-blind clinical trial. | periampullary neoplasms are rapidly progressive tumors with a poor prognosis and high morbidity and mortality rates, which have a negative influence on patient outcomes. some probiotics and prebiotics have the ability to protect the intestinal barrier and prevent bacterial translocation, infection, and postoperative complications. we evaluated the use of synbiotics in a prospective, double-blind study of patients undergoing surgery for periampullary neoplasms (pns) and assessed the effect of the ... | 2015 | 25803626 |
| short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease. | : although numerous animal studies suggest that probiotic therapy has beneficial effects in various liver diseases, the evidence for beneficial effects in human liver disease is controversial. this study was carried out to investigate the efficacy of probiotic therapy in alleviating small intestinal bacterial overgrowth (sibo) and permeability in chronic liver disease. | 2014 | 25244414 |
| a multispecies probiotic reduces oral candida colonization in denture wearers. | the prevalence of candida infections has been rising with an increasingly aging population and a larger population of immunocompromised individuals. the use of probiotics may be an alternative approach to antifungal agents in the prevention and treatment of oral candidiasis. this study aimed to evaluate the short-term effect of probiotics in reducing the infection level of oral candida in candidiasis-asymptomatic elderly denture wearers. | 2015 | 25143068 |
| role of probiotics in the prevention and treatment of meticillin-resistant staphylococcus aureus infections. | meticillin-resistant staphylococcus aureus (mrsa) is a multidrug-resistant micro-organism and is the principal nosocomial pathogen worldwide. following initial in vitro experiments demonstrating that lactobacillus acidophilus cl1285(®) and lactobacillus casei lbc80r(®) commercial strains exhibit antibacterial activity against clinical mrsa isolates, we conducted a literature search to find any evidence of probiotic efficacy in decolonisation or treatment of s. aureus infection. as summarised bel ... | 2013 | 24071026 |
| effect of water-soluble fraction of cherry tomatoes on the adhesion of probiotics and salmonella to intestinal epithelial cells. | tomato is one of the most consumed vegetables in the world and contains many valuable nutritional components. here we investigate the prebiotic effects of cherry tomatoes for improving gut health. | 2013 | 23749725 |
| association of a probiotic to a helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study. | the treatment for the eradication of helicobacter pylori (h. pylori) is complex; full effectiveness is rarely achieved and it has many adverse effects. in developing countries, increased resistance to antibiotics and its cost make eradication more difficult. probiotics can reduce adverse effects and improve the infection treatment efficacy.if the first-line therapy fails a second-line treatment using tetracycline, furazolidone and proton-pump inhibitors has been effective and low cost in brazil; ... | 2013 | 23530767 |
| treatment of nonalcoholic steatohepatitis with probiotics. a proof-of-concept study. | probiotics have profound effect on nonalcoholic steatohepatitis (nash) in animal models. we aimed to test the hypothesis that probiotics treatment was superior to usual care in reducing liver fat in nash patients. | 2015 | 23396737 |
| probiotics lactobacillus rhamnosus gg, lactobacillus acidophilus suppresses dmh-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in sprague dawley rats. | diet makes an important contribution to colorectal cancer (crc) risk implying risks for crc are potentially reducible. therefore, the probiotics have been suggested as the prophylactic measure in colon cancer. in this study, different probiotics were used to compare their protective potential against 1,2 dimethylhydrazine dihydrochloride (dmh)-induced chemical colon carcinogenesis in sprague dawley rats. animals belonging to different probiotic groups were fed orally with 1 × 10(9) lactobacilli ... | 2013 | 23368917 |
| antimicrobial potential for the combination of bovine lactoferrin or its hydrolysate with lactoferrin-resistant probiotics against foodborne pathogens. | previous reports have shown that several probiotic strains can resist the antibacterial activity of bovine lactoferrin (blf), but the results are inconsistent. moreover, a portion of orally administered apo-blf is digested in vivo by pepsin to yield blf hydrolysate, which produces stronger antibacterial activity than that observed with apo-blf. however, whether blf hydrolysate affects the growth of probiotic strains is unclear. therefore, various probiotic strains in taiwan were collected and ev ... | 2013 | 23332852 |
| the effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in turkey: single blinded randomized study. | probiotics have been successfully used for the treatment of acute diarrhea in children and this effect depends on the strains and dose. the aim of this study was to assess the effect of a synbiotic mixture on the duration of diarrhea and the length of hospital stay in children with acute watery diarrhea. this is a prospective randomized, multicenter single blinded clinical trial in hospitalized children with acute watery diarrhea. all children were treated with conventional hydration therapy wit ... | 2013 | 23239048 |
| is a multispecies probiotic mixture effective in constipation during pregnancy? 'a pilot study'. | constipation during pregnancy is a common problem. nowadays only few effective interventions are published preventing or treating constipation during pregnancy. however, their use is limited due to side-effects. this uncontrolled intervention study was performed to determine if a mixture of probiotics in the treatment of constipation during pregnancy is effective. | 2012 | 23035837 |
| reduction of patulin in aqueous solution by lactic acid bacteria. | this study aims to investigate the ability of lactic acid bacteria (lab) to remove patulin (pat) from aqueous solution with respect to the bacterial viability, initial pat concentration, incubation time, temperature, and ph. the removal of pat determined by high-performance liquid chromatography (hplc) coupled with uv detector. the maximum pat uptake was achieved by bifidobacterium bifidum 6071 and lactobacillus rhamnosus 6149 strains (52.9% and 51.1%) for viable and (54.1% and 52.0%) for nonvia ... | 2012 | 22394296 |
| the role of probiotics in the treatment of dysentery: a randomized double-blind clinical trial. | diarrhea is considered as an important cause of morbidity and mortality, even though one of the main reasons of death following diarrhea is initiated by dysentery. in recent years, the consumption of probiotics has been proposed for the treatment of infectious diarrhea. despite most of the studies on probiotics have focused on acute watery diarrhea, few studies in the field of dysentery have found beneficial effects of probiotics. this study is a randomized double-blind clinical trial. the patie ... | 2017 | 28321826 |
| a multi-strain synbiotic may reduce viral respiratory infections in asthmatic children: a randomized controlled trial. | asthma is a growing problem worldwide. acute exacerbations impose considerable morbidity, mortality, and increased cost. viral respiratory infections are the most common cause (80-85%) of pediatric asthma exacerbations and admissions to the hospital. the aim of this study was to determine the effect of a new synbiotic lactocare® on viral respiratory infections and asthma exacerbations in asthmatic children. | 2016 | 27790333 |
| absence of adverse events in healthy individuals using probiotics--analysis of six randomised studies by one study group. | consumption of live bacteria as probiotic supplements is increasing. there is, however, a lack of information on the safety of ingested probiotics. the main objective of this study was to investigate the adverse events (aes) of specific probiotics (lactobacillus rhamnosus gg (lgg) alone or lgg in combination with l. rhamnosus lc705, propionibacterium freudenreichii js, bifidobacterium lactis bb12, or bifidobacterium breve 99) studied in six of our study groups' clinical trials, by analysing indi ... | 2016 | 26689224 |
| specific probiotic dietary supplementation leads to different effects during remission and relapse in murine chronic colitis. | although interest in using probiotics to prevent and treat intestinal diseases is increasing, the effects of specific probiotic strains still remain unclear. here, we assess the therapeutic effects of two probiotic strains, lactobacillus rhamnosus nutres 1 and bifidobacterium breve nutres 204 on a dextran sodium sulphate (dss)-induced chronic murine colitis model. the chronic colitis was induced by two dss treatment cycles with a rest period of 10 days (the remission or resolution phase). the pr ... | 2016 | 26645352 |
| effect of supplements: probiotics and probiotic plus honey on blood cell counts and serum iga in patients receiving pelvic radiotherapy. | radiotherapy is frequently used in treatment approaches of pelvic malignancies. nevertheless, it has some known systemic effects on blood cells and the immune system that possibly results in their susceptibility to infection. probiotics are live microbial food ingredients that provide a health advantage to the consumer. honey has prebiotic properties. the aim of this clinical trial was to investigate probable effects of probiotic or probiotics plus honey on blood cell counts and serum iga levels ... | 2015 | 26622258 |
| effects of probiotics on biomarkers of oxidative stress and inflammatory factors in petrochemical workers: a randomized, double-blind, placebo-controlled trial. | the aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers. | 2015 | 26445629 |