Publications

gene expression changes during the gummosis development of peach shoots in response to lasiodiplodia theobromae infection using rna-seq.	lasiodiplodia theobromae is a causal agent of peach (prunus persica l.) tree gummosis, a serious disease affecting peach cultivation and production. however, the molecular mechanism underlying the pathogenesis remains unclear. rna-seq was performed to investigate gene expression in peach shoots inoculated or mock-inoculated with l. theobromae. a total of 20772 genes were detected in eight samples; 4231, 3750, 3453, and 3612 differentially expressed genes were identified at 12, 24, 48, and 60 h a ...	2016	27242544
data from mass spectrometry, nmr spectra, gc-ms of fatty acid esters produced by lasiodiplodia theobromae.	the data described herein is related to the article with the title "fatty acid esters produced by lasiodiplodia theobromae function as growth regulators in tobacco seedlings" c.c. uranga, j. beld, a. mrse, i. cordova-guerrero, m.d. burkart, r. hernandez-martinez (2016) [1]. data includes nuclear magnetic resonance spectroscopy and gc-ms data used for the identification and characterization of fatty acid esters produced by l. theobromae. gc-ms traces are also shown for incubations in defined subs ...	2016	27274528
3-o-β-d-glucopyranosyltheobroxide from aerial parts of cowpea (vigna unguiculata).	theobroxide has been isolated from culture filtrates of lasiodiplodia theobromae as a potato tuber-inducing compound. in this study, the metabolism of theobroxide was investigated using cowpea as an experimental model and [2h3-7]theobroxide as a substrate for analyzing a metabolite, which revealed that theobroxide applied exogenously to the roots was converted into 3-o-β-d-glucopyranosyltheobroxide.	2016	27319148
chemopreventive effect and lack of genotoxicity and mutagenicity of the exopolysaccharide botryosphaeran on human lymphocytes.	carbohydrate biopolymers of fungal-origin are an important natural resource in the search for new bioagents with therapeutic and nutraceutical potential. in this study the mutagenic, genotoxic, antigenotoxic and antioxidant properties of the fungal exopolysaccharide botryosphaeran, a (1→3)(1→6)-β-d-glucan, from botryosphaeria rhodina mamb-05, was evaluated. the mutagenicity was assessed at five concentrations in salmonella typhimurium by the ames test. normal and tumor (jurkat cells) human t lym ...	2016	27387458
novel cyclohexene compound from lasiodiplodia theobromae ifo 31059.	a novel cyclohexene compound (1), which is structurally related to theobroxide (2), was isolated from a culture filtrate of the fungus, lasiodiplodia theobromae ifo 31059. the potato micro-tuber-inducing activity of this compound was observed at a concentration of 10(-3) m in the medium, whereas theobroxide (2) showed its activity at 10(-5) m.	1998	27392405
global transcriptional analysis suggests lasiodiplodia theobromae pathogenicity factors involved in modulation of grapevine defensive response.	lasiodiplodia theobromae is a fungus of the botryosphaeriaceae that causes grapevine vascular disease, especially in regions with hot climates. fungi in this group often remain latent within their host and become virulent under abiotic stress. transcriptional regulation analysis of l. theobromae exposed to heat stress (hs) was first carried out in vitro in the presence of grapevine wood (gw) to identify potential pathogenicity genes that were later evaluated for in planta expression.	2016	27514986
temperature modulates the secretome of the phytopathogenic fungus lasiodiplodia theobromae.	environmental alterations modulate host-microorganism interactions. little is known about how climate changes can trigger pathogenic features on symbiont or mutualistic microorganisms. current climate models predict increased environmental temperatures. the exposing of phytopathogens to these changing conditions can have particularly relevant consequences for economically important species and for humans. the impact on pathogen/host interaction and the shift on their biogeographical range can in ...	2016	27536303
cytotoxic and antibacterial preussomerins from the mangrove endophytic fungus lasiodiplodia theobromae zj-hq1.	two new chlorinated preussomerins, chloropreussomerins a and b (1 and 2), together with nine known preussomerin analogues, 3-11, were obtained from the endophytic fungus lasiodiplodia theobromae zj-hq1. their structures were elucidated by a combination of spectroscopic analyses. the absolute configurations of 1 and 2 were both determined by single-crystal x-ray diffraction using cu kα radiation. chloropreussomerins a and b (1 and 2) are the first chlorinated compounds in the preussomerin family, ...	2016	27560695
invasive fungal sinusitis by lasiodiplodia theobromae in an patient with aplastic anemia: an extremely rare case report and literature review.	human lasiodiplodia theobromae infection has not been reported frequently. we report the first case of invasive l. theobromae nasal and neck infection. a 66-year-old male visited our hospital with anemia and general weakness. he showed pancytopenia, and his bone marrow examination revealed markedly decreased hematopoietic cells. the patient was presumed to have iatrogenic aplastic anemia due to mushroom toxicity. he began treatment for multiple organ infections with broad-spectrum antibiotics an ...	2016	27650099
metabolomics-guided isolation of anti-trypanosomal metabolites from the endophytic fungus lasiodiplodia theobromae.	fungal endophytes offer diverse and unique secondary metabolites, making these organisms potential sources of promising drug leads. the application of high-resolution-liquid chromatography mass spectrometry and nuclear magnetic resonance-based metabolomics to fungal endophytes is practical in terms of dereplication studies and the mining of bioactive compounds. in this paper, we report the application of metabolomics in parallel with anti-trypanosomal assays to determine the ideal conditions for ...	2016	27760442
successful treatment of lasiodiplodia theobromae keratitis - assessing the role of voriconazole.	the aim of this paper is to report the successful management of the first case of lasiodiplodia theobromae keratitis in hong kong.	2017	27843433
optimized jasmonic acid production by lasiodiplodia theobromae reveals formation of valuable plant secondary metabolites.	jasmonic acid is a plant hormone that can be produced by the fungus lasiodiplodia theobromae via submerged fermentation. from a biotechnological perspective jasmonic acid is a valuable feedstock as its derivatives serve as important ingredients in different cosmetic products and in the future it may be used for pharmaceutical applications. the objective of this work was to improve the production of jasmonic acid by l. theobromae strain 2334. we observed that jasmonic acid formation is dependent ...	2016	27907207
banana peel culture as an indigenous medium for easy identification of late-sporulation human fungal pathogens.	fungi are increasing in incidence as human pathogens and newer and rarer species are continuously being encountered. identifying these species from growth on regular culture media may be challenging due to the absence of typical features. an indigenous and cheap medium, similar to the natural substrate of these fungi, was standardised in our laboratory as an aid to species identification in a conventional laboratory setting.	2017	27934823
seedborne pathogenic fungi in common bean (phaseolus vulgaris cv. inta rojo) in nicaragua.	common bean (phaseolus vulgaris l.) is an important legume with high nutritional value. in nicaragua, certified healthy seeds of local bean varieties are not available, and seedborne fungi have gained little attention. here, were surveyed seedborne pathogenic fungi in an important local bean cultivar, 'inta rojo'. beans grown in the four main production areas in nicaragua (boaco, carazo, estelí, matagalpa) for future use as seed stock were sampled from four seed storehouses and six seed lots. a ...	2016	27997595
in vitro protective effects of botryosphaeran, a (1→3;1→6)-β-d-glucan, against mutagens in normal and tumor rodent cells.	botryosphaeran (bot) is an exocellular β-d-glucan (carbohydrate biopolymer) of the (1→3;1→6)-linked type produced by botryosphaeria rhodina mamb-05. the cytotoxic, mutagenic, genotoxic, and protective effects of this substance were evaluated in chinese hamster lung fibroblasts (v79) and rat hepatocarcinoma cells (htc) by the micronucleus test (mn) and the comet assay. bot was not genotoxic in either cell line; it decreased the clastogenic effects of doxorubicin, h2o2, and benzo[a]pyrene. these r ...	2017	28137365
first report of dieback caused by lasiodiplodia theobromae in strawberry plants in korea.	dieback in strawberry (seolhyang cultivar) was first observed during the nursery season (june to september) in the nonsan area of korea in the years 2012 and 2013. initial disease symptoms included dieback on runners, as well as black rot on roots, followed by wilting and eventually blackened, necrotic discoloration in the crowns of daughter plants. a fungus isolated from the diseased roots, runners, and crowns is close to lasiodiplodia theobromae based on morphological characteristics. analysis ...	2016	28154491
agarwood formation induced by fermentation liquid of lasiodiplodia theobromae, the dominating fungus in wounded wood of aquilaria sinensis.	agarwood is broadly used in incense and medicine. traditionally, agarwood formation is induced by wounding the trunks and branches of some species of aquilaria spp., including a. sinensis. as recently evidenced, some fungi or their fermentation liquid may have the potential of inducing agarwood formation. the present study aimed to analyze the fungi isolated from an agarwood-producing a. sinensis tree and subsequently identify the fungi capable of promoting agarwood formation. we identified a to ...	2017	28224223
intracerebroventricular administration of the (1→6)-β-d-glucan (lasiodiplodan) in male rats prevents d-penicillamine-induced behavioral alterations and lipoperoxidation in the cortex.	lasiodiplodan, an exocellular (1→6)-β-d-glucan of molecular weight >1.4 × 10(6) da produced by mmpi strain of lasiodiplodia theobromae (pat.) griffon & maubl. (brotyosphaeriaceae) is known to exhibit anti-proliferative activity on breast cancer cells (mcf-7), anticoagulant activity when sulfonylated, and reduction in transaminase activity when administered in rats.	2017	28274189
analysis of phylogeny, distribution, and pathogenicity of botryosphaeriaceae species associated with gummosis of anacardium in brazil, with a new species of lasiodiplodia.	netto, m. s. b., lima, w. g., correia, k. c., da silva, c. f. b., thon, m., martins, r. b., miller, r. n. g., michereff, s. j., and câmara, m. p. s. 2016. analysis of phylogeny, distribution, and pathogenicity of botryosphaeriaceae species associated with gummosis of anacardium in brazil, with a new species of lasiodiplodia. we identified botryosphaeriaceae species associated with gummosis on anacardium in brazil. isolates were sampled and identified on the basis morphology and phylogeny, throug ...	2017	28317544
phylogeny and pathogenicity of lasiodiplodia species associated with dieback of mango in peru.	mango, which is an important tropical fruit crop in the region of piura (peru), is known to be prone to a range of diseases caused by lasiodiplodia spp. the aim of this study was to evaluate the incidence and prevalence of mango dieback in the region of piura, and to identify the species of lasiodiplodia associated with the disease and evaluate their pathogenicity towards mango. mango dieback was present in all orchards surveyed but incidence varied with location. identification of fungal isolat ...	2017	28317545