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an unusual skin lesion caused by lasiodiplodia theobromae.we describe a case of subcutaneous infection as a result of traumatic implantation caused by the fungus lasiodiplodia theobromae. it was isolated in multiple swabs from the foot of an active healthy male. the fungus was identified by traditional mycology culture methods though this was slow with much time required for sporulation on only one of the agars used. identification was confirmed by dna sequencing. the patient was successfully treated with voriconizole.201525893164
improved cellulase production by botryosphaeria rhodina from opefb at low level moisture condition through statistical optimization.the response surface method was applied in this study to improve cellulase production from oil palm empty fruit bunch (opefb) by botryosphaeria rhodina. an experimental design based on a two-level factorial was employed to screen the significant environmental factors for cellulase production. the locally isolated fungus botryosphaeria rhodina was cultivated on opefb under solid-state fermentation (ssf). from the analysis of variance (anova), the initial moisture content, amount of substrate, and ...201222394064
modulation of gene expression and cell cycle by botryosphaeran, a (1→3)(1→6)-β-d-glucan in human lymphocytes.there is growing interest in the anticancer and immunomodulatory potential of fungal β-d-glucans. in the present study, the modulation of gene expression via rt-qpcr and cell cycle kinetics via flow cytometry were assessed in human normal and tumor (jurkat) lymphocytes after treatment with botryosphaeran (a fungal (1→3)(1→6)-β-d-glucan) from botryosphaeria rhodina mamb-05. cell cultures were treated with botryosphaeran either alone, or in combination with doxorubicin (dxr), in a post-treatment p ...201525795388
characterisation of the metabolites of an antibacterial endophyte botryodiplodia theobromae pat. of dracaena draco l. by lc-ms/ms.botryodiplodia theobromae pat. belongs to the endophytic fungi that live within the tissues of medicinal plants and produce bioactive natural products. the endophyte was isolated from the leaves of dracaena draco l. the lc-ms-based metabolite fingerprinting of the ethyl acetate extract of b. theobromae with antibacterial activity led to the identification of 13 metabolites pertaining to various classes: dipeptides (maculosin and l,l-cyclo(leucylprolyl), alkaloid (norharman), coumarin and isocoum ...201525693860
[keratitis by lasiodiplodia theobromae: a case report and literature review].we report a case of mycotic keratitis caused by lasiodiplodia theobromae in a 60-year-old man with a history of ocular trauma with vegetable matter. ophthalmological assessment with slit-lamp and microbiological evaluation of the corneal ulcer by conventional microbiological techniques were performed. mycology study of the corneal scraping showed the presence of fungal filaments and the isolate was identified as lasiodiplodia theobromae. patient was treated with natamycin 5% and fluconazole 0.2% ...201425679935
treatment with intrastromal and intracameral voriconazole in 2 eyes with lasiodiplodia theobromae keratitis: case reports.to report the clinical presentation and the role of intrastromal and intracameral voriconazole injection in the management of rare cases of fungal keratitis caused by lasiodiplodia theobromae.two eyes of 2 patients with lasiodiplodia keratitis unresponsive to topical and oral antifungal medications were included in this study. diagnosis of lasiodiplodia keratitis was confirmed by microbiological analysis, including culture-based (case 1 and 2) and dna sequencing techniques (case 2 only).the firs ...201525674759
proteomic analysis of responsive stem proteins of resistant and susceptible cashew plants after lasiodiplodia theobromae infection.gummosis is an aggressive disease caused by the necrotrophic fungus lasiodiplodia theobromae (pat.) griffon & maubl that threatens commercial cashew orchads in brazil. to study the molecular mechanisms involved in the cashew response to l. theobromae, a proteomic analysis of stems from the commercial cashew clone brs 226 (resistant) was conducted at early times post-artificial infection. in addition, changes in the stem proteome profiles of gummosis resistant and susceptible cashew plants grown ...201525289588
free-radical scavenging properties and antioxidant activities of botryosphaeran and some other β-d-glucans.β-d-glucans are known to present antitumor, anticancer, and anti-inflammatory activities that are influenced by their own antioxidant capacity. the antioxidant activity of botryosphaeran, an exopolysaccharide of the (1 → 3;1 → 6)-β-d-glucan type produced by the botryosphaeria rhodina mamb-05 was evaluated and compared to some other β-d-glucans (lasiodiplodan an exocellular (1 → 6)-β-d-glucan from lasiodiplodia theobromae, laminarin and curdlan), and oligosaccharides, disaccharides, and monosacch ...201525128096
dieback and sooty canker of ficus trees in egypt and its control.this study was designed to throw lights on dieback and canker disease on urban trees of ficus sp. in egypt, its causal pathogens and disease control. diseased samples were collected from five locations. pathogenicity test was done on one year old of three different healthy seedlings of ficus trees (ficus benghalensis, ficu snitida and ficus hawaii). lasiodiplodia theobromae and phomopsis sp. were consistently isolated from infected tissues and were pathogenic. the fungicides antracol combi and t ...201424897790
novel cyclohexene compound from lasiodiplodia theobromae ifo 31059.a novel cyclohexene compound (1), which is structurally related to theobroxide (2), was isolated from a culture filtrate of the fungus, lasiodiplodia theobromae ifo 31059. the potato micro-tuber-inducing activity of this compound was observed at a concentration of 10(-3) m in the medium, whereas theobroxide (2) showed its activity at 10(-5) m.199827392405
insights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in saccharomyces cerevisiae.the phytotoxic fungal polyketides lasiodiplodin and resorcylide inhibit human blood coagulation factor xiiia, mineralocorticoid receptors, and prostaglandin biosynthesis. these secondary metabolites belong to the 12-membered resorcylic acid lactone (ral12) subclass of the benzenediol lactone (bdl) family. identification of genomic loci for the biosynthesis of lasiodiplodin from lasiodiplodia theobromae and resorcylide from acremonium zeae revealed collaborating iterative polyketide synthase (ipk ...201424597618
simultaneous quantification of phytohormones in fermentation extracts of botryodiplodia theobromae by liquid chromatography-electrospray tandem mass spectrometry.fermentation broth and biomass from three strains of botryodiplodia theobromae were characterized by high performance liquid chromatography-electrospray tandem mass spectrometry (hplc-esi-ms/ms) method, in order to quantify different phytohormones and to identify amino acid conjugates of jasmonic acid (ja) present in fermentation broths. a liquid-liquid extraction with ethyl acetate was used as sample preparation. the separation was carried out on a c18 reversed-phase hplc column followed by ana ...201424510403
toxicological assessment of β-(1-->6)-glucan (lasiodiplodan) in mice during a 28-day feeding study by gavage.studies evaluating the toxicity caused by fungal exopolysaccharides of the β-(1-->6)-d-glucan type are rare. in this study, the toxicological effects of sub-chronic treatments with lasiodiplodan (β-(1-->6)-d-glucan from lasiodiplodia theobromae mmpi) were evaluated in mice through the assessment of biochemical, hematological, and histopathological alterations. thirty-two mice (16 male, 16 female) were used in this study divided in two groups; one group received lasiodiplodan (50 mg/kg body weigh ...201223208465
catalytic asymmetric synthesis of butane diacetal-protected (4s,5s)-dihydroxycyclohexen-1-one and use in natural product synthesis.due to the lack of availability of unnatural (+)-quinic acid as a starting material, a 6-step synthesis of butane diacetal-protected (4s,5s)-dihydroxycyclohexen-1-one (formally derived from (+)-quinic acid) has been devised. the key catalytic asymmetric step involves a chiral co-salen-catalysed epoxide ring-opening reaction. (4s,5s)-dihydroxycyclohexen-1-one was utilised in the synthesis of two cyclohexenone natural products isolated from the mycelia of lasiodiplodia theobromae.201222930235
one-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation.a series of novel isoindoline-1,3-diones containing 1,2,4-triazole moiety were synthesized via a one-pot reaction. bioassay indicated that compounds 33, 35, 37 and 39 exhibited much higher activities against botryodiplodia theobromae than commercial fungicide triadimefon at the dosage of 150 mg/l. most interestingly, compounds 36, 37 and 45 displayed much stronger antitumor activities against four human cell lines than positive control fluorouracil. particularly, compound 37 had four-fold improv ...201222809558
carbohydrate metabolism changes in prunus persica gummosis infected with lasiodiplodia theobromae.peach gummosis represents a significant global disease of stone fruit trees and a major disease in the south peach production area of the yangtze river of china. in this study, the carbohydrate composition of peach shoots during infection by lasiodiplodia theobromae was examined. the expression of genes related to metabolic enzymes was also investigated. control wounded and noninoculated tissue, lesion tissue, and wounded and inoculated surrounding lesion tissue of peach shoots were analyzed. so ...201424283537
keratitis due to the wood saprobic ascomycete, auerswaldia lignicola (family botryosphaeriaceae), in a carpenter in india.keratitis due to auerswaldia lignicola in a 32-year-old indian male carpenter is described. at presentation, the patient reported persistent pain and tearing (left eye) in spite of topical antimicrobial therapy for more than 3 weeks. clinically, mycotic keratitis was suspected, and direct microscopy of corneal scrapings stained by lactophenol cotton blue and gram stains revealed broad septate hyphae. intensive topical antifungal therapy was then given for 15 days. the keratitis continued to prog ...201324158617
[identification of pathogen of aquilaria sinensis dieback disease].the research focused on identification the pathogen of aquilaria sinensis dieback disease and confirmation the function of inducing agarwood formation by fungi.201324010282
optimization of culture conditions for some identified fungal species and stability profile of α-galactosidase produced.microbial α-galactosidase preparations have implications in medicine and in the modification of various agricultural products as well. in this paper, four isolated fungal strains such as al-3, wf-3, wp-4 and cl-4 from rhizospheric soil identified as penicillium glabrum (al-3), trichoderma evansii (wf-3), lasiodiplodia theobromae (wp-4) and penicillium flavus (cl-4) based on their morphology and microscopic examinations, are screened for their potential towards α-galactosidases production. the cu ...201323424684
[bioremediation of pahs contaminated soil from beijing coking plant by lasiodiplodia theobromae].bioremediation of pahs contaminated soil from beijing coking plant was performed using a novel fungal strain lasiodiplodia theobromae (l. theobromae). moreover, enhanced bioremediation of pahs contaminated soil was investigated in the presence of different concentrations of tween 80 and hydroxypropyl-beta-cyclodextrin (hpcd). the correlation of the dynamics of enzyme activities during remediation and the degradation of pahs was analyzed. the results showed that the degradation rate of pahs incre ...201223213912
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