| allelopathic effects ofcitrus aurantium l. : i. vegetational patterning. | field observations on undisturbed stands of sour orange revealed thatcynodon dactylon, chenopodium album, avena sativa, andamaranthus retroflexus were not able to grow normally and complete their life cycles under its canopies, although the same species grow well under adjacent trees of date palm. investigations revealed that the failure of the test species to grow normally under sour orange was not due to competition for light, moisture and minerals or to differences in soil texture or ph. soil ... | 1985 | 24311244 |
| isolation and identification of insecticidal components from citrus aurantium fruit peel extract. | three active components were identified by bioassay-guided fractionation of bitter orange ( citrus aurantium l.) fruit peel petroleum ether extract. silica gel fractionation of the extract yielded a fraction that inflicted up to 96% mortality to adults of the olive fruit fly bactrocera oleae (gmelin) three days post-treatment. subsequent hplc purification of the active fraction resulted in the isolation of three components, eluted in fractions f 222, f 224, and f 226, that induced adult mortalit ... | 2008 | 18578532 |
| insecticidal activity of citrus aurantium fruit, leaf, and shoot extracts against adult olive fruit flies (diptera: tephritidae). | solvent extracts of differing polarity from citrus aurantium (l.) (rutaceae) fruit, leaves, and shoots were evaluated for biological activity against adults of the olive fruit fly, bactrocera oleae (gmelin) (diptera: tephritidae). using a petri dish residual exposure bioassay, we found that the petroleum ether extract from fruit alone showed insecticidal activity against the flies. the extract of the three fruit tissues (flavedo [peel], albedo, and flesh) indicated that bioactivity was limited t ... | 2007 | 17849873 |
| estimate of yield loss from the citrus nematode in texas grapefruit. | chemical control of the citrus nematode, tylenchulus semipenetrans cobb, has consistently increased yield of grapefruit on sour orange rootstock in texas. in this study, data from chemical control tests conducted from 1973 to 1980 were analyzed to determine the relationship between nematode counts and grapefruit yield and fruit size. the correlation between yield and nematode counts was negative (r = -0.47) and highly significant (p < 0.01). the data best fit the exponential decay curve: y = 160 ... | 1982 | 19295756 |
| [treatment of chronic colitis with an herbal combination of taraxacum officinale, hipericum perforatum, melissa officinaliss, calendula officinalis and foeniculum vulgare]. | twenty four patients with chronic non-specific colitis were treated with a herb combination. as a result from the treatment, the spontaneous and palpable pains along the large intestine disappeared in 95.83 per cent of the patients by the 15th day of their admission to the clinic. defecation became daily in the patients with obstipation syndrome, but a combination of rhamus frangula, citrus aurantium, c. carvi was added to the herb combination already indicated. defecation was normalized in pati ... | 1981 | 7336706 |
| metals content in herbal supplements. | obesity has become an international epidemic. to evaluate the level of metals in extracts of plants prescribed as weight loss supplements, different brands containing camellia sinensis (l.) kuntze, citrus aurantium l., cordia ecalyculata vell, ilex paraguariensis a. st.-hil, cissus quadrangularis l., senna alexandrina mill were purchased in local market, hot acid digested, and analyzed while metal content by inductively coupled plasma optical emission spectrometry, icp-oes. quality assurance and ... | 2017 | 27344673 |
| adverse effects of plant food supplements and plants consumed as food: results from the poisons centres-based plantlibra study. | plant food supplements (pfs) are products of increasing popularity and wide-spread distribution. nevertheless, information about their risks is limited. to fill this gap, a poisons centres-based study was performed as part of the eu project plantlibra. multicentre retrospective review of data from selected european and brazilian poisons centres, involving human cases of adverse effects due to plants consumed as food or as ingredients of food supplements recorded between 2006 and 2010. ten poison ... | 2016 | 26948409 |
| accumulation and transport of (2,4-dichlorophenoxy)acetic acid in plant cuticles: i. sorption in the cuticular membrane and its components. | partition coefficients (k) of (2,4-dichlorophenoxy)acetic acid (2,4-d) have been determined for the system plant cuticle/aqueous buffer. cuticles isolated enzymatically from leaves (clivia miniata, ficus elastica, citrus aurantium, hedera helix, pyrus communis cv. conférence and cv. williams, olea europaea) and fruits (lycopersicon esculentum, capsicum annuum, solanum melongena, cucumis sativus) were utilized. only the nondissociated species of 2,4-d was sorbed by cuticles and their lipophilic c ... | 1984 | 6734501 |
| cardiovascular safety of oral p-synephrine (bitter orange) in healthy subjects: a randomized placebo-controlled cross-over clinical trial. | bitter orange (citrus aurantium) extract and its primary protoalkaloid p-synephrine are widely consumed in combination with multiple herbal ingredients for weight management and sports performance. p-synephrine is also present in juices and foods derived from a variety of citrus species. questions exist regarding the safety of p-synephrine because of structural similarities with other biogenic amines. this study assessed the cardiovascular (stimulatory) effects of bitter orange extract (49-mg p- ... | 2016 | 26948284 |
| [risk assessment of synephrine in dietary supplements]. | synephrine is a sympathomimetic phenylethylamine derivative that occurs naturally in citrus fruits. it is often added to dietary supplements intended for weight loss and enhancement of sports performance, typically in the form of citrus aurantium extracts and in many cases in combination with caffeine. the health risks of synephrine were evaluated on the basis of the available toxicological data and in accordance to the efsa guidance on the safety assessment of botanicals and botanical preparati ... | 2017 | 28058460 |
| analysis of pharmaceutical adulterants in plant food supplements by uhplc-ms/ms. | a method based on the quick, easy, cheap, effective, rugged, and safe (quechers) extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (uhplc-ms/ms) was successfully developed and validated for the analysis of 26 pharmaceutical compounds belonging to different therapeutic classes (anorexics, stimulants, anxiolytics, antidepressants and laxatives), which are all prone to be illegally added into weight-loss plant food supplements (pfs) for their pharmacolo ... | 2017 | 28027941 |
| control of stress-induced depressive disorders by so-ochim-tang-gamibang, a korean herbal medicine. | so-ochim-tang-gamibang (socg) is a korean herbal medicine formula that has been applied to treat depressive moods and depression associated somatoform pain. this decoction consists of cyperus rotundus l. (cyperi rhizoma), lindera aggregata (sims) kosterm. (linderae radix), aquilaria agallochum (lour.) roxb. ex finl. (aquilariae resinatum lignum), glycyrrhiza uralensis fisch. (glycyrrhizae radix) platycodon grandiflorum (jacq.) a. dc. (platycodi radix), and citrus aurantium l. (aurantii fructus). ... | 2017 | 27988398 |
| systemic resistance in citrus to tetranychus urticae induced by conspecifics is transmitted by grafting and mediated by mobile amino acids. | recent research suggests that systemic signalling and communication between roots and leaves plays an important role in plant defence against herbivores. in the present study, we show that the oviposition of the two-spotted spider mite tetranychus urticae in the systemic leaves of citrus rootstock citrus aurantium (sour orange) was reduced by 50% when a lower leaf was previously infested with conspecifics. metabolomic and gene expression analysis of the root efflux revealed a strong accumulation ... | 2016 | 27683726 |
| effects of lemon and seville orange juices on the pharmacokinetic properties of sildenafil in healthy subjects. | several severe drug interactions have been reported when sildenafil, a potent drug for the treatment of erectile dysfunction, is co-administered with drugs or herbal remedies that inhibit cytochrome p450 (cyp) 3a4. this study evaluates the effects of two citrus fruit juices, lemon and seville orange, on the pharmacokinetics of sildenafil in male healthy subjects following a single oral dose. | 2016 | 27550653 |
| different anti-adipogenic effects of bio-compounds on primary visceral pre-adipocytes and adipocytes. | several natural compounds exhibit strong capacity for decreasing triglyceride accumulation, enhancing lipolysis and inducing apoptosis. the present study reports the anti-adipogenic effects of silybum marianum (sl), citrus aurantium (ca), taraxacum officinale (to), resveratrol (re), curcuma longa (cu), caffeine (cf), oleuropein (ol) and docosahexaenoic acid (dha) in reducing differentiation and increasing lipolysis and apoptosis. analyses were performed on human primary visceral pre-adipocytes a ... | 2016 | 27540349 |
| localization of the transpiration barrier in the epi- and intracuticular waxes of eight plant species: water transport resistances are associated with fatty acyl rather than alicyclic components. | plant cuticular waxes play a crucial role in limiting nonstomatal water loss. the goal of this study was to localize the transpiration barrier within the layered structure of cuticles of eight selected plant species and to put its physiological function into context with the chemical composition of the intracuticular and epicuticular wax layers. four plant species (tetrastigma voinierianum, oreopanax guatemalensis, monstera deliciosa, and schefflera elegantissima) contained only very-long-chain ... | 2016 | 26644508 |
| the effects of supplementation with p-synephrine alone and in combination with caffeine on metabolic, lipolytic, and cardiovascular responses during resistance exercise. | the purpose of this study was to examine the metabolic, lipolytic, and cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during resistance exercise (re). | 2016 | 27484437 |
| antidepressant-like effect of the water extract of the fixed combination of gardenia jasminoides, citrus aurantium and magnolia officinalis in a rat model of chronic unpredictable mild stress. | water extract of the fixed combination of gardenia jasminoides ellis fruit, citrus aurantium l. fruit and magnolia officinalis rehd. et wils. bark, traditional name - zhi-zi-hou-po (zzhpd) is used for treatment of depressive-like symptoms in traditional chinese medicine for centuries. | 2015 | 26598917 |
| [isolation and structural identification of flavonoids from aurantii fructus]. | aurantii fructus is the dried and immature fruit of citrus aurantium and its cultivars. to investigate the chemical constituents of aurantii fructus, the separation and purification of constituents were performed by column chromatography on silica gel lh-20, hw-40, ods, phplc and ptlc. fourteen flavonoids, including four flavone glycosides and ten polymethoxyflavones (pmfs) were isolated from the etoac fraction and petroleum ether fraction of aurantii fructus and their structures were identified ... | 2015 | 26591524 |
| endothelium- and smooth muscle-dependent vasodilator effects of citrus aurantium l. var. amara: focus on ca(2+) modulation. | neroli, the essential oil of citrus aurantium l. var. amara, is a well-characterized alleviative agent used to treat cardiovascular symptoms. however, because it has been found to have multiple effects, its mechanism of action requires further exploration. we sought to clarify the mechanism underlying the actions of neroli in mouse aorta. in aortic rings from mice precontracted with prostaglandin f2 alpha, neroli induced vasodilation. however, relaxation effect of neroli was decreased in endothe ... | 2016 | 27470386 |
| overview of regulation of dietary supplements in the usa and issues of adulteration with phenethylamines (peas). | the multi-billion dollar dietary supplement industry is global in reach. the industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. in this review, we describe how the us food and drug administration (fda) regulates dietary supplements within the framework of the federal food, drug, and cosmetic act (fd&c act). the dietary supplement health and education act of 1994 (dshea), which amended the fd&c act, gave the fda the authority to promu ... | 2017 | 27259162 |
| studies on water transport through the sweet cherry fruit surface: ix. comparing permeability in water uptake and transpiration. | water uptake and transpiration were studied through the surface of intact sweet cherry (prunus avium l.) fruit, exocarp segments (es) and cuticular membranes (cm) excised from the cheek of sweet cherry fruit and astomatous cm isolated from schefflera arboricola (hayata) hayata, citrus aurantium l., and stephanotis floribunda brongn. leaves or from lycopersicon esculentum mill. and capsicum annuum l. var. annuum fasciculatum group fruit. es and cm were mounted in diffusion cells. water (deionized ... | 2005 | 15338307 |
| multicomponent, multitarget integrated adjustment - metabolomics study of qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine. | qizhiweitong particles (qzwt) which is derived from the sinisan decoction in shang han za bing lun, composed of bupleurum chinenis, paeonia obovata, citrus aurantium l., glycyrrhiza uralensis fisch., cyperus rotundus and rhizoma corydalis is a traditional chinese medicine (tcm) treating gastrointestinal diseases. it have been used in clinical for years. it have been used in clinical for years. according to previous research, bupleurum chinenis, citrus aurantium, cyperus rotundus in qzwt play the ... | 2016 | 27180317 |
| a preliminary investigation of anticholinesterase activity of some iranian medicinal plants commonly used in traditional medicine. | the aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in iran to introduce a new source for management of alzheimer's disease. a total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants: brassica alba, brassica nigra, camellia sinensis, cinchona officinalis, citrus aurantifolia, citrus x aurantium, ferula assafoetida, humulus lupulus, juglans regia, juniperus sabina, myristica fragrans, pelargonium graveolens, pist ... | 2014 | 24401532 |
| effect of s. macrosiphon and l. perfoliatum seed gums on rheological characterization of bitter orange (citrus aurantium l.) and pomegranate (punica granatum l.) paste blends. | the steady shear flow properties of bitter orange and pomegranate pastes and blend of two pastes including 0.5% salvia macrosiphon (smg) and l. perfoliatum (lpg) seed gums, two traditional iranian hydrocolloids, were determined. all treatments exhibited shear-thinning behaviour. lpg added sample showed stronger shear thinning behaviour than the other due to its high molecular weight and intermolecular through hydrogen bonds and polymer entanglement. ostwald model was found the best model to desc ... | 2016 | 27162409 |
| phytochemical compounds in sport nutrition: synephrine and hydroxycitric acid (hca) as examples for evaluation of possible health risks. | numerous food supplements contain phytochemical compounds as active ingredients. though such supplements are often perceived by consumers as being risk-free, the safety of many of them is currently uncertain. the present review provides two examples for risk assessment for phytochemical ingredients which are used in certain supplements marketed for sportspeople - synephrine (extracted from fruits of citrus aurantium) and hydroxycitric acid (hca, isolated from fruits of garcinia cambogia). animal ... | 2017 | 28271601 |
| acute p-synephrine ingestion increases fat oxidation rate during exercise. | p-synephrine is a protoalkaloid widely used in dietary supplements for weight management because of its purported thermogenic effects. however, there is a lack of scientific information about its effectiveness to increase fat metabolism during exercise. the purpose of this investigation was to determine the effects of an acute ingestion of p-synephrine on fat oxidation at rest and during exercise. | 2016 | 27038225 |
| two new phenolic glycosides isolated from the fruits of citrus aurantium. | the present study was designed to investigate the chemical constituents of the fruit of citrus aurantium l.. the compounds were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. two new phenolic glycosides (compounds 1 and 2) were obtained and identified as 1-o-3, 5-dihydroxyphenyl-(6-o-4-hydroxybenzoyl)-β-d-glucopyranoside (1) and 1-o-3, 5-dihydroxyphenyl-(6-o-3-methoxy-4-hydroxy benzoy ... | 2017 | 28259251 |
| immune enhancement effects and extraction optimization of polysaccharides from citrus aurantium l. var. amara engl. | the crude polysaccharides of citrus aurantium l. var. amara engl (cavaps) were extracted and their bioactivities including dpph radical scavenging activity, cytotoxicity to human breast cancer cells, mcf-7, as well as lung cancer cells, hcc827, and their immune-enhancement activity were evaluated. results showed that cavaps exhibited better immunoenhancement activity compared to the dpph radical scavenging and anticancer activities. subsequently, the immune enhancement activity of cavaps on raw2 ... | 2017 | 28121002 |
| high-performance thin-layer chromatography/desorption electrospray ionization mass spectrometry imaging of the crude extract from the peels of citrus aurantium l. (rutaceae). | citrus aurantium l. is a plant belonging to the rutaceae family, whose extracts are extensively used in weight management products and as thermogenic agents. here we present two methodologies to analyse the extracts obtained from the peels of citrus aurantium l. that usually require multiple sample preparation and detection steps. | 2015 | 26212168 |
| activity antifungal of the essential oils; aqueous and ethanol extracts from citrus aurantium l. | our study is about the essential oil of citrus aurantium l. in tunisia and its plant extract. the yield of this essential oil is 0, 56% but the yield of the extract of plant was 17.1% for the aqueous extract ant 18.3% for the ethanolic extract. the analysis of chemical composition by using gc and gc/ms showed the essential oil of c. aurantium l. species to be rich in monoterpenes such as α-terpineol, lianolyl acetate, linalool and limonene. the antifungal activity of this oil showed us an inhibi ... | 2015 | 26207731 |
| germinating seeds of citrus aurantium a good source of bioactive limonoids. | a simple method to obtain extracts enriched in bioactive limonoids from citrus aurantium l. seeds has been developed, using solvents of increasing polarity. 1h nmr data from the extracts revealed that the highest amounts of limonoids were present in the t-butylmethylether extract. the comparison between extracts obtained from dormant and germinating seeds showed that the latter contained almost double amounts of limonoids, revealing germinating seeds as an excellent source of those bioactive com ... | 2015 | 26197503 |
| hesperetin suppresses inflammatory responses in lipopolysaccharide-induced raw 264.7 cells via the inhibition of nf-κb and activation of nrf2/ho-1 pathways. | hesperetin (hesp), a common flavanone glycoside, was extracted from the fruit peel of citrus aurantium l. (rutaceae). hesp has been shown to possess various biological properties, including antioxidant, neuroprotective, and anti-inflammatory properties. in this study, we investigated the protective effect of hesp on inflammatory responses in lipopolysaccharide (lps)-induced raw 264.7 cells. our results indicated that hesp treatment dramatically suppressed secretion of tumor necrosis factor (tnf) ... | 2016 | 26994999 |
| effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance. | the purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (pws) with and without p-synephrine (s) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. | 2017 | 28096758 |
| hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication. | in the present study, we explore the protective effects of citrus aurantium l. extract (cae) against acute and chronic ccl4-induced hepatotoxicity. the quantitative analysis of cae was performed using hplc-uv to determine the nobiletin content was approximately 27%. for the acute model, the male icr mice were orally treated with water, silymarin (positive control, 200 mg/kg) and cae (50 and 200 mg/kg) for 3 days prior to ccl4 (1 ml/kg, 50% v/v in olive oil) ip injection. for the chronic model (n ... | 2016 | 26980244 |
| citrus plants: a model system for unlocking the secrets of no and ros-inspired priming against salinity and drought. | plants treated with chemical compounds can develop an enhanced capacity to resist long after being subjected to (a)biotic stress, a phenomenon known as priming. evidence suggests that reactive oxygen species (ros) and reactive nitrogen species (rns) coordinately regulate plant stress responses to adverse environmental conditions; however, the mechanisms underlying this function remain unknown. based on the observation that pre-exposure of citrus (citrus aurantium l.) roots to the no donor sodium ... | 2016 | 26955378 |
| a review on botanical species and chemical compounds with appetite suppressing properties for body weight control. | as obesity has reached epidemic proportions, the management of this global disease is of clinical importance. the availability and popularity of natural dietary supplements for the treatment of obesity has risen dramatically in recent years. the purpose of this paper was to review the effect of commonly available over the counter plant-derived supplements used to suppress appetite for obesity control and management. the data were obtained from the electronic databases pubmed, springerlink, googl ... | 2013 | 23666454 |
| chemical evidence for potent xanthine oxidase inhibitory activity of ethyl acetate extract of citrus aurantium l. dried immature fruits. | xanthine oxidase is a key enzyme which can catalyze hypoxanthine and xanthine to uric acid causing hyperuricemia in humans. xanthine oxidase inhibitory activities of 24 organic extracts of four species belonging to citrus genus of the family rutaceae were assayed in vitro. since the ethyl acetate extract of c. aurantium dried immature fruits showed the highest xanthine oxidase inhibitory activity, chemical evidence for the potent inhibitory activity was clarified on the basis of structure identi ... | 2016 | 26950105 |
| effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males. | the purpose of this study was to examine whether ingesting a pre-workout dietary supplement (pws) with and without synephrine (s) during training affects training responses in resistance-trained males. | 2017 | 28096757 |
| fast hepatic biotransformation of p-synephrine and p-octopamine and implications for their oral intake. | citrus aurantium (bitter orange) extracts have been used in products for weight management and sports performance. these extracts contain large amounts of p-synephrine and much smaller amounts of p-octopamine. both protoalkaloids exert lipolytic and glycogenolytic activities at similar concentrations. the biotransformation of p-synephrine and p-octopamine is not as well-known as those of other adrenergic amines. for this reason transformation of these amines was investigated in the isolated perf ... | 2016 | 26883936 |
| novel immunoassay and rapid immunoaffinity chromatography method for the detection and selective extraction of naringin in citrus aurantium. | in this work, a novel monoclonal antibody specific for naringin was prepared and characterized. subsequently, an indirect competitive enzyme-linked immunosorbent assay for naringin was developed, with an effective range from 4.8 to 156 ng/ml naringin. next, an immunoaffinity column was obtained by coupling anti-naringin monoclonal antibodies to cnbr-activated sepharose 4b and a rapid immunoaffinity chromatography assay for naringin was developed. the immunoaffinity column was used to separate na ... | 2016 | 26864564 |
| anxiolytic effect of citrus aurantium l. on patients with chronic myeloid leukemia. | the bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. the present study assessed the effect of citrus aurantium l. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (cml). volunteers from both sexes were divided into groups receiving either the c. aurantium essential oil through inhalation, diazepam ... | 2016 | 26787366 |
| a new phenolic glycoside and two new monoterpenoid furocoumarins from aurantii fructus immaturus. | a new phenolic glycoside, citrauranoside a (1), and two new monoterpenoid furocoumarins, citraurancoumarin a (2) and citraurancoumarin b (3), along with four known compounds (4-7) were isolated from the young fruit of citrus aurantium l. the structures were elucidated by their comprehensive analysis including 1d, 2dnmr, ir and mass spectra. | 2016 | 26728329 |
| acute consumption of p-synephrine does not enhance performance in sprint athletes. | p-synephrine is a protoalkaloid widely used as an ergogenic aid in sports. this substance has been included in the world anti-doping agency monitoring program, although scientific information about its effects on performance and athletes' well-being is scarce. the purpose of this investigation was to determine the effectiveness of p-synephrine to increase performance in sprint athletes. in a randomized and counterbalanced order, 13 experienced sprinters performed 2 acute experimental trials afte ... | 2016 | 26673246 |
| citrus peel extract incorporated ice cubes to protect the quality of common pandora: fish storage in ice with citrus. | the objective of this study was to investigate the effects of ice with albedo and flavedo fragments of citrus (grapefruit (citrus paradisi) and bitter orange (citrus aurantium l.)) extracts on the quality of common pandora (pagellus erythrinus). concentrated citrus extracts were diluted with distilled water (1/100 w/v) before making of ice. the ice cubes were spread on each layer of fishes and stored at 0 °c for 15 days. the ph value showed a regular increase in all samples. tvb-n levels of bitt ... | 2015 | 26604414 |
| a systematic review of the anxiolytic-like effects of essential oils in animal models. | the clinical efficacy of standardized essential oils (such as lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. a systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. the essential oil with the best profile is lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. citrus aurantium ... | 2015 | 26473822 |
| sexual competitiveness of anastrepha ludens (diptera: tephritidae) males exposed to citrus aurantium and citrus paradisi essential oils. | males of the mediterranean fruit fly (ceratitis capitata (wiedemann)) display increased mating competitiveness following exposure to the odor of certain host and nonhost plants, and this phenomenon has been used in the sterile insect technique to boost the mating success of released, sterile males. here, we aimed to establish whether males of the mexican fruit fly (anastrepha ludens (loew)) gain a mating advantage when exposed to the aroma of two preferred hosts, grapefruit (citrus paradisi macf ... | 2015 | 26470173 |
| flavonoids of korean citrus aurantium l. induce apoptosis via intrinsic pathway in human hepatoblastoma hepg2 cells. | korean citrus aurantium l. has long been used as a medicinal herb for its anti-inflammatory, antioxidant, and anticancer properties. the present study investigates the anticancer role of flavonoids extracted from c. aurantium on human hepatoblastoma cell, hepg2. the citrus flavonoids inhibit the proliferation of hepg2 cells in a dose-dependent manner. this result was consistent with the in vivo xenograft results. apoptosis was detected by cell morphology, cell cycle analysis, and immunoblot. fla ... | 2015 | 26439681 |
| gc-fid/ms profiling of supercritical co2 extracts of peels from citrus aurantium, c. sinensis cv. washington navel, c. sinensis cv. tarocco and c. sinensis cv. doppio sanguigno from dubrovnik area (croatia). | the peels of citrus aurantium l. and citrus sinensis osbeck cultivars from the dubrovnik region (south croatia) were extracted by supercritical co2 at 40 degrees c and 10 mpa at 1.76 kg/h to obtain enriched extracts in comparison with simple pressing of the peels. the extracts were analyzed in detail by gas chromatography and mass spectrometry (gc-fid/ms). relevant similarities among the peel oil compositions of c. aurantium and c. sinensis cultivars were found with limonene predominance (up to ... | 2015 | 26411039 |
| aromatherapy with citrus aurantium oil and anxiety during the first stage of labor. | anxiety is the most common psychological response of women to labor. aromatherapy, i.e. the use of fragrant essential oils to stimulate the olfactory system, can create a state of calmness and help to alleviate anxiety. | 2014 | 25068058 |
| absence of furanocoumarins in advantra z® (citrus aurantium, bitter orange) extracts. | grapefruit (citrus paradisi) juice is known for its ability to alter drug metabolism through inhibition of the cytochrome p450-3a4 (cyp3a4) system, and result in drug-food interactions that may be life threatening. the primary active ingredients in grapefruit responsible for these effects are the furanocoumarins bergapten, bergamottin, and 6',7'-dihydroxybergamottin (dhb). bergamottin and dhb appear to be the most important in terms of adverse drug interactions. furanocoumarins are present in th ... | 2014 | 25026202 |
| efficacy of mint (mentha arvensis) leaf and citrus (citrus aurantium) peel extracts as natural preservatives for shelf life extension of chill stored indian mackerel. | efficacy of mint (mentha arvensis) leaf and citrus (citrus aurantium) peel extracts in retarding the quality changes in indian mackerel during chilled storage was investigated. mint leaf extract showed higher quantity of phenolics and superior in-vitro antioxidant activities than citrus peel extract. gutted mackerel were given a dip treatment in mint extract (0.5 %, w/v) and citrus extract (1 % w/v), packed in ldpe pouches and stored at 0-2 °c. the biochemical quality indices viz. total volatile ... | 2015 | 26396373 |
| a new species of brevipalpus donnadieu (acari: tenuipalpidae) and key to the egyptian species. | a new species, brevipalpus noranae sp. nov. (acari: tenuipalpidae) is described and illustrated from females collected on malus domestica borkh and citrus aurantium l. a key to the species of the genus brevipalpus present in egypt is provided. | 2014 | 24869810 |
| anti-oxidant, anti-inflammatory and anti-proliferative activities of moroccan commercial essential oils. | essential oils (eo) possess antimicrobial, anti-inflammatory, insect repellent, anti-cancer, and antioxidant properties, among others. in the present work, the antioxidant, anti-inflammatory and anti-proliferative activities of moroccan commercial eos (citrus aurantium, c. limon, cupressus sempervirens, eucalyptus globulus, foeniculum vulgare and thymus vulgaris) were evaluated and compared with their main constituents. t. vulgaris eo showed the best free radicals scavenging capacity. this eo wa ... | 2014 | 24868891 |
| unsupported conclusions in the article "synephrine-containing dietary supplement precipitating apical ballooning syndrome in a young female". | | 2014 | 24851076 |
| properties and limits of some essential oils: chemical characterisation, antimicrobial activity, interaction with antibiotics and cytotoxicity. | because of the emergence of multi-drug resistance bacteria and fungi, alternatives to conventional antimicrobial therapy are needed. this study aims to evaluate in vitro the antimicrobial activity of: mirtus communis, coriandrum sativum, pelargonium capitatum, cuminum cyminum, ocimum basilicum, citrus aurantium amara, cymbopogon. winterianus, cymbopogon martini, salvia sclarea, melaleuca alternifolia and mentha suaveolens essential oils on bacteria and fungi, in relation to their chemical compos ... | 2016 | 26395247 |
| the effects of fructus aurantii extract on the 5-hydroxytryptamine and vasoactive intestinal peptide contents of the rat gastrointestinal tract. | fructus aurantii, the unripe fruit of citrus aurantium linn (rutaceae), is a qi-regulating drug used in traditional chinese medicine to improve gastrointestinal (gi) function. vasoactive intestinal peptide (vip) and 5-hydroxytryptamine (5-ht) regulate gi motility and fluid secretion. | 2014 | 24707973 |
| effect of hesperidin and neohesperidin from bittersweet orange (citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats. | hesperidin and neohesperidin are the major flavanones isolated from bittersweet orange. it was recently reported that they have potent anti-inflammatory effects in various inflammatory models. in the present study, the effects of hesperidin and neohesperidin on indomethacin-induced ulcers in rats and the underlying mechanisms were investigated. gastric ulcers were induced in rats with a single dose of indomethacin. the effects of pretreatment with hesperidin and neohesperidin were assessed in co ... | 2014 | 24691249 |
| ultrasonic nebulization extraction/low pressure photoionization mass spectrometry for direct analysis of chemicals in matrices. | a novel ultrasonic nebulization extraction/low-pressure photoionization (une-lppi) system has been designed and employed for the rapid mass spectrometric analysis of chemicals in matrices. an ultrasonic nebulizer was used to extract the chemicals in solid sample and nebulize the solvent in the nebulization cell. aerosols formed by ultrasonic were evaporated by passing through a transferring tube, and desolvated chemicals were ionized by the emitted light (10.6 ev) from a krypton discharge lamp a ... | 2015 | 26388379 |
| p-synephrine: a novel agonist for neuromedin u2 receptor. | in the brain, neuromedin u2 receptor (nmu2r) is prominent in the hypothalamic regions and is known to be associated with regulation of several important physiological functions, including food intake, energy balance, stress response, and nociception. in this article, by random screening of compounds using the model of high-throughput screening for nmu2r stable expression, nmu2r negative and nmu2r short hairpin rna (shrna) knockdown hek293 cell lines, for the first time, we discovered that p-syne ... | 2014 | 24598981 |
| acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and citrus aurantium. | we describe the case of a previously healthy 22-year-old man who presented with anginal chest pain and was diagnosed with a non-st-elevation myocardial infarction. for 3 weeks, he had been ingesting the dietary supplements jack3d® (principal ingredient, 1,3-dimethylamylamine) and phenorex™ (principal ingredient, citrus aurantium) daily, before undertaking physical activity. coronary angiograms revealed a proximal left anterior descending coronary artery thrombus with distal embolization. a combi ... | 2014 | 24512406 |
| an untargeted metabolomics-driven approach based on lc-tof/ms and lc-ms/ms for the screening of xenobiotics and metabolites of zhi-zi-da-huang decoction in rat plasma. | zhi-zi-da-huang decoction (zzdhd), a typical traditional chinese medicine prescription, is widely used in clinical practice for the treatment of alcoholic liver disease. however, due to lack of holistic metabolic research, the active ingredients of zzdhd have not been fully elucidated. it entails a huge obstacle for the quality evaluation, pharmacokinetic studies and clinical-safe medication administration of zzdhd. in this work, an untargeted metabolomics-driven approach was proposed to rapidly ... | 2015 | 26275719 |
| obesity phytotherapy: review of native herbs used in traditional medicine for obesity. | obesity is an important disorders due to which 25 million deaths occur annually worldwide. synthetic drugs for weight loss have low efficacy and high side effects. apart from synthetic drugs in modern medicine, various other methods including the use of herbal medications are used to induce weight loss. cambodia hoodia, green tea, citrus aurantium, white beans, fenugreek, caffeine, ephedrine, capsaicin, yohimbine, chitosan, fitostreols, and guar gum have been studied in clinical trials and their ... | 2016 | 26269377 |
| [diagnostic workup of fragrance allergy]. | the diagnostic workup of contact allergy to fragrances must not be limited to patch testing with the two well-established fragrance mixes. false-positive reactions to these mixes occur in up to 50 % of the patch tested patients. for the diagnostic work-up of positive reactions, and in cases of suspected fragrance allergy, patch testing with the single mix components and additional fragrances is mandatory. frequently sensitizing fragrance materials are the 14 components of the two fragrance mixes ... | 2015 | 26253114 |
| a polymethoxy flavonoids-rich citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of ampk and nrf2-related signals in a binge drinking mouse model. | nobiletin and tangeretin are polymethoxy flavonoids (pmfs), found in rich quantities in the peel of citrus fruits. in the present study, we assessed the biological effect of the pmfs on liver damage using a mouse model of binge drinking. first, we extracted pmfs from the peels of citrus aurantium to make citrus aurantium extract (cae). male c57bl/6 mice were orally treated with silymarin and cae (50, 100, and 200 mg/kg) for 3 days prior to ethanol (5 g/kg, total of 3 doses) oral gavage. liver in ... | 2015 | 26178909 |
| comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of magnolia officinalis cortex extract and its compatibility with other herbal medicines in zhi-zi-hou-po decoction to rats. | zhi-zi-hou-po decoction (zzhpd) is one of the famous antidepressant chinese formulas and is composed of magnolia officinalis cortex (hp), gardenia jasminoides ellis (zz) and citrus aurantium l. (zs). magnolol (mn) and honokiol (hn) from hp are the major active ingredients responsible for the therapeutic effects of zzhpd. the aim of this study is to compare the pharmacokinetics and rat brain distribution of mn and hn after oral administration of hp extract and its compatibility with other herbal ... | 2016 | 26173910 |
| [progress in research of traditional chinese medicine citrus aurantium]. | citrus aurantium is one of the most common traditional chinese medicines. in this paper, the chemical components, content determination and pharmacological actions of c. aurantium were summarized for the comprehensive utilization of its resources. because of the complicated resources of c. aurantium, only one single component as index couldn't reflect the quality and effects and comprehensive evaluation which concluding multiple components should be established in the future quality control. in ... | 2015 | 26080542 |
| identification of the chemical constituents in aqueous extract of zhi-qiao and evaluation of its antidepressant effect. | the immature fruit of citrus aurantium l. (zhi-qiao, zq) has been used as a traditional medicine in china. our previous study has shown that zq decoction may contribute to the antidepressant-like action of chaihu-shu-gan-san. however, there are no reports on the chemical constituents of zq aqueous extract or its anti-depression effects. firstly, this research reported the on-line identification of the chemical constituents in the aqueous extract of zq by coupling ultra-performance liquid chromat ... | 2015 | 25913931 |
| identification of the absorbed components and metabolites of zhi-zi-da-huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. | zhi-zi-da-huang decoction (zzdhd), consisting of gardenia jasminoides ellis, rheum palmatum l., citrus aurantium l. and sojae semen praeparatum, is a widely used traditional chinese medicine preparation for the treatment of acute or chronic hepatic diseases. in the present study, a sensitive and selective ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (uhplc-q-tof-ms) method was developed to separate and identify the absorbed components and ... | 2015 | 25912849 |
| plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. | research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. however, a comprehensive review of plant-based anxiolytics has been absent to date. thus, our aim was to provide a comprehensive narrative review of plant-based medicines that have clinical and/or preclinical evidence of anxiolytic activity. we present the article in two parts. in part one, we reviewed herbal ... | 2013 | 23653088 |
| toxic potentials of ten herbs commonly used for aphrodisiac effect in turkey. | sexual dysfunction is a serious problem worldwide. in turkey, herbal products are used by some people suffering from sexual dysfunction. despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in turkey. | 2015 | 26281312 |
| plant chimeras: the good, the bad, and the 'bizzaria'. | chimeras - organisms that are composed of cells of more than one genotype - captured the human imagination long before they were formally described and used in the laboratory. these organisms owe their namesake to a fire-breathing monster from greek mythology that has the head of a lion, the body of a goat, and the tail of a serpent. the first description of a non-fictional chimera dates back to the middle of the seventeenth century when the florentine gardener pietro nati discovered an adventit ... | 2016 | 27381079 |
| adrenergic metabolic and hemodynamic effects of octopamine in the liver. | the fruit extracts of citrus aurantium (bitter orange) are traditionally used as weight-loss products and as appetite suppressants. a component of these extracts is octopamine, which is an adrenergic agent. weight-loss and adrenergic actions are always related to metabolic changes and this work was designed to investigate a possible action of octopamine on liver metabolism. the isolated perfused rat liver was used to measure catabolic and anabolic pathways and hemodynamics. octopamine increased ... | 2013 | 24196353 |
| flooding impairs fe uptake and distribution in citrus due to the strong down-regulation of genes involved in strategy i responses to fe deficiency in roots. | this work determines the ffects of long-term anoxia conditions--21 days--on strategy i responses to iron (fe) deficiency in citrus and its impact on fe uptake and distribution. the study was carried out in citrus aurantium l. seedlings grown under flooding conditions (s) and in both the presence (+fe) and absence of fe (-fe) in nutritive solution. the results revealed a strong down-regulation (more than 65%) of genes ha1 and fro2 coding for enzymes proton-atpase and ferric-chelate reductase (fc- ... | 2015 | 25897804 |
| a representative survey of knowledge, use, perceived benefits, barriers, and risks of select herbal drugs among female students in gorgan city (northeast iran). | we conducted a representative survey among young women to determine knowledge, use, and perceptions on barriers, benefits, and risks related to selected herbal drugs (crocus sativus, borago officinalis, citrus aurantium, thymus vulgaris, matricaria chamomilla, lavandula angustifolia, valeriana officinalis, hypericum perforatum, and panax ginseng) in gorgan by using an internally validated questionnaire. there were 344 participants (mean age 16.3 years; 16.2% in science course). saffron had most ... | 2016 | 26888451 |
| hypoglycemic and hypolipidemic effects of neohesperidin derived from citrus aurantium l. in diabetic kk-a(y) mice. | the present study is to investigate the possible hypoglycemic and hypolipidemic effects of neohesperidin (nhp) derived from citrus aurantium l. in vivo. kk-a(y) mice were used as the diabetic experimental model, whereas c57bl/6 mice were used as normal control for a 6-week study. treatment of nhp significantly decreased fasting glucose, serum glucose, and glycosylated serum protein (gsp) in kk-a(y) mice. it significantly elevated oral glucose tolerance and insulin sensitivity and decreased insul ... | 2015 | 25620042 |
| anticonvulsant activity of citrus aurantium blossom essential oil (neroli): involvment of the gabaergic system. | citrus aurantium l. blossoms are an important medicinal plant part in iran and some other countries. it is used in traditional medicine as an antiseizure and anticonvulsant natural agent. early in vitro research of the anticonvulsant activity of the blossom extracts were done but there has been no investigation focused on the blossom essential oil and its anticonvulsant activity. the anticonvulsant activity of the essential oil of c. aurantium blossoms (neroli) was investigated. the anticonvulsa ... | 2014 | 25532295 |
| problems with citrus aurantium information in "a review on botanical species and chemical compounds with appetite suppressing properties for body weight control". | various botanical extracts are used as adjuncts in treating obesity. a recent review concerning botanical products used to suppress appetite has included a discussion of citrus aurantium and p-synephrine. the authors have incorrectly equated the actions of c. aurantium with ephedra in terms of adrenergic receptor binding, pharmacological effects and safety. current research literature is reviewed which clarifies these issues. | 2013 | 23904205 |
| melatonin combined with ascorbic acid provides salt adaptation in citrus aurantium l. seedlings. | ascorbic acid (asa) and melatonin (mel) are known molecules participating in stress resistance, however, their combined role in counteracting the impact of salinity in plants is still unknown. in this work the effect of exogenous application of 0.50 mμ asa, 1 μμ mel and their combination (asa + mel) on various stress responses in leaves and roots of citrus aurantium l. seedlings grown under 100 mμ nacl for 30 days was investigated. application of asa, mel or asa + mel to saline solution decrease ... | 2015 | 25500452 |
| chinese herbal medicine for obesity: a randomized, double-blinded, multicenter, prospective trial. | obesity is a serious medical problem worldwide. as a holistic therapy, traditional chinese medicine (tcm) may have a potential in obesity management. in this controlled trial, we evaluated the safety and effectiveness of xin-ju-xiao-gao-fang (xjxgf), a tcm herbal formulation, in 140 obese subjects over a 24-week period. the xjxgf formula mainly consists of rhubarb, coptis, semen cassia, and citrus aurantium. subjects with body mass index (bmi) 28-40 kg/m(2) were recruited at 5 centers in china. ... | 2014 | 25406653 |
| anti-amnesic activity of citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. | alzheimer's disease (ad) is a progressive neurological disorder that mostly affects the elderly population. learning and memory impairment as the most characteristic manifestation of dementia could be induced chemically by scopolamine, a cholinergic antagonist. cholinergic neurotransmission mediated brain oxidative stress. citrus aurantium (ca) has traditionally been used for the treatment of insomnia, anxiety and epilepsy. the present study was designed to investigate the effect of citrus auran ... | 2015 | 25367404 |
| anti-hiv-1 activity of eight monofloral iranian honey types. | monofloral iranian honeys from eight floral sources were analyzed to determine their anti-hiv-1 activities as well as their effects on lymphocyte proliferation. the peripheral blood mononuclear cells (pbmcs) used in this study were prepared from five healthy volunteers who were seronegative for hiv, hcv, hbv and tb. the anti-hiv-1 activity of eight different honeys was performed by quantitative polymerase chain reaction (pcr) assay and high pure viral nucleic acid kit. the results demonstrated t ... | 2014 | 25333699 |
| [study on determination of anthraquinones in dachengqi tang residues of magnolia officinalis and citrus aurantium removed in decoction process]. | the traditional decoction method of dachengqi tang is that "first boiling magnolia officinalis and citrus aurantium with a pipeful of water, taking out five litres from the decoction, removing residues, adding rheum officinale, boiling again, taking out two litres from it, removing residues, adding mirabilite, boiling it with low fire". according to it, residues of m. officinalis and c. aurantium should be removed after decocting. this essay aims to study the content of anthraquinones, in order ... | 2013 | 23724678 |
| [effect of different compatibility of zhizi dahuang decoction on pharmacokinetics of naringenin and hesperetin]. | an hplc-uv method was developed for the determination of total naringenin and total hesperetin in rat plasma after oral administration of citrus aurantium immaturus extracts and zhizi dahuang decoction. plasma samples were pretreated with liquid-liquid extraction procedure and acid hydrolysis method was used for converting conjugated naringenin and hesperetin to their respective free forms. plasma samples were separated on a c18 column (4.6 mm x 150 mm, 5 microm), using 0.1% phosphoric acid and ... | 2014 | 25276981 |
| effects of citrus aurantium (bitter orange) on the severity of first-stage labor pain. | considering that vaginal delivery is a painful process, the present study investigated the effects of citrus aurantium on the severity of first-stage labor pain in primiparous women. this study was a randomized clinical trial conducted with 126 eligible primiparous patients. the pain severity of patients was measured at the time of enrolling in the study. in the intervention group, (aromatherapy) gauze squares were soaked in 4 ml of c. aurantium distillated water, and in the control group, gauze ... | 2014 | 25276203 |
| new insights into dietary supplements used in sport: active substances, pharmacological and side effects. | as a society we are increasingly concerned about our physical appearance. for example, as much as 24% of people in developed countries admittedly exercise to improve their performance. professional sportsmen and amateurs alike are in a constant search for new means that will enable them better sport results in shorter time. among those means, a prominent place belongs to dietary supplements. however, the producers often advertise products whose use in sports is neither scientifically founded nor ... | 2013 | 23574283 |
| questionable conclusions in the article "cardiovascular toxicity of citrus aurantium in exercised rats". | | 2013 | 23568750 |
| characterization of chemical constituents in zhi-zi-da-huang decoction by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. | a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established to separate and identify the chemical constituents of zhi-zi-da-huang decoction, a classic traditional chinese medicine formula. the chromatographic separation was achieved on a shim-pack xr-ods c18 column (75 × 3.0 mm, 2.2 μm) using a gradient elution program. the detection was performed on a waters xevo g2 q-tof mass spectrometer equipped with el ... | 2014 | 25195935 |
| effects of inhalation of essential oil of citrus aurantium l. var. amara on menopausal symptoms, stress, and estrogen in postmenopausal women: a randomized controlled trial. | this study aimed to investigate the effects of inhalation of the essential oil of citrus aurantium l. var. amara (neroli oil) on menopausal symptoms, stress, and estrogen in postmenopausal women. sixty-three healthy postmenopausal women were randomized to inhale 0.1% or 0.5% neroli oil or almond oil (control) for 5 minutes twice daily for 5 days. menopause-related symptoms, as determined by the menopause-specific quality of life questionnaire (menqol); sexual desire visual analog scale (vas); se ... | 2014 | 25024731 |
| nephroprotective potentials of citrus aurantium: a prospective pharmacological study on experimental models. | citrus aurantium is traditionally used in various kidney problems like burning of urine, urinary hesitancy and renal colic. the main objective of the present work was to evaluate the protective role of citrus aurantium against gentamicin induced renal damage, due to its free radical scavenging properties to present experimental facts for their traditional use. 200 mg/kg/day of ethanolic extract of the plant employed in combination with the toxic doses of gentamicin for twenty-one days. the group ... | 2014 | 24811809 |
| structural characterization and antioxidant activities of polysaccharides from citrus aurantium l. | three polysaccharide fractions were obtained from citrus aurantium l. (cal) by sequential extraction with cold water, hot water, and 1.0m naoh, respectively. the fractions were denoted cala, calb, and calc. structural characterization was conducted by physicochemical property, ftir, and sem analyses. antioxidant activities in vivo and in vitro were also evaluated. calb, which showed the highest activity, was further isolated to afford four purified polysaccharides (calb-1-4) by various ion excha ... | 2014 | 24631547 |
| a 60day double-blind, placebo-controlled safety study involving citrus aurantium (bitter orange) extract. | bitter orange (citrus aurantium) extract and its primary protoalkaloid p-synephrine are widely consumed in dietary supplements for weight management and sports performance. p-synephrine is also present in foods derived from a variety of citrus species. bitter orange extract is commonly used in combination with multiple herbal ingredients. most clinical studies conducted on bitter orange extract alone have involved single doses. the purpose of this study was to assess the safety of bitter orange ... | 2013 | 23354394 |
| the essential oil of bergamot stimulates reactive oxygen species production in human polymorphonuclear leukocytes. | bergamot (citrus aurantium l. subsp. bergamia) essential oil (beo) is used in folk medicine as an antiseptic and anthelminthic and to facilitate wound healing. evidence indicates that beo has substantial antimicrobial activity; however its effects on immunity have never been examined. we studied the effects of beo on reactive oxygen species (ros) production in human polymorphonuclear leukocytes (pmn) and the role of ca(2+) in the functional responses evoked by beo in these cells. results show th ... | 2014 | 24458921 |
| citrus aurantium increases seizure latency to ptz induced seizures in zebrafish thru nmda and mglur's i and ii. | epilepsy is a serious neurological condition and pharmacotherapy is not effective for all patients and causes serious adverse effects and pharmacokinetic and pharmacodynamic interactions. natural products and ethnobotanical resources can help develop new therapeutic options for conditions like epilepsy. in puerto rico, ethnobotanical resources highlight the anxiolytic properties of a tea like preparation made from the leaves of the citrus aurantium tree or bitter orange. studies performed with e ... | 2014 | 25762932 |
| effect of naringenin on brain insulin signaling and cognitive functions in icv-stz induced dementia model of rats. | recent evidence indicates that severe abnormalities in brain glucose/energy metabolism and insulin signaling have been documented to take a pivotal role in early sporadic alzheimer's disease pathology. it has been reported that naringenin (nar), derived from citrus aurantium, exhibits antioxidant potential and protects the brain against neurodegeneration. the current study was designed to further investigate the protective effect of the nar on neurodegeneration in a rat model of ad induced by an ... | 2014 | 24337945 |
| a method for fast analysis of volatile components of citrus aurantium l. leaves. | to avoid the traditional and time consuming hydrodistillation, the analyses of volatile components in leaves of citrus aurantium l. were carried out by a simple microwave distillation followed by headspace single drop microextraction (md-hs-sdme) coupled to gas chromatography-mass spectrometry (gc-ms). the headspace volatile compounds were collected after irradiation using a single drop of n-heptadecan. the extraction conditions were optimized using the relative peak areas as index. the chemical ... | 2013 | 23039826 |
| healing actions of essential oils from citrus aurantium and d-limonene in the gastric mucosa: the roles of vegf, pcna, and cox-2 in cell proliferation. | previous studies have described the gastroprotective effects of essential oils that are derived from citrus aurantium (oec) and its main compound d-limonene (lim) in a model of chemically induced ulcers in rats. however, these studies do not address the compound's healing effects on the gastric mucosa. thus, the aim of this work was to evaluate the healing activity of oec and lim in acetic acid-induced gastric ulcers in rats, a model that reproduces human chronic ulcers. the obtained results dem ... | 2013 | 24328705 |
| induction of the cell cycle arrest and apoptosis by flavonoids isolated from korean citrus aurantium l. in non-small-cell lung cancer cells. | this study investigated the anti-proliferative and apoptotic effect of flavonoids isolated from korean citrus aurantium l. using a549 lung cancer cells. flavonoids potently inhibited of a549 cells in a dose-dependent manner, whereas flavonoids had a weak inhibitory effect on proliferation of wi-38 cells. flow cytometry and western blot analysis showed that flavonoids induced cell cycle arrest at the g2/m checkpoint by controlling the proteins expression level of cyclin b1, cdc2, cdc25c and p21(w ... | 2012 | 22980865 |
| does citrus leaf miner impair hydraulics and fitness of citrus host plants? | gas exchange and hydraulic features were measured in leaves of three different citrus species (citrus aurantium l., citrus limon l., citrus × paradisii macfad) infested by phyllocnistis citrella staiton, with the aim to quantify the impact of this pest on leaf hydraulics and, ultimately, on plant fitness. infested leaves were characterized by the presence on the leaf blade of typical snake-shaped mines and, in some cases, of a crumpled leaf blade. light microscopy showed that leaf crumpling wa ... | 2013 | 24319027 |
| oxidative stress-related lung dysfunction by chromium(vi): alleviation by citrus aurantium l. | chromium(vi), a very strong oxidant, causes high cytotoxicity through oxidative stress in tissue systems. our study investigated the potential ability of ethanolic citrus aurantium l., family rutaceae extract, used as a nutritional supplement, to alleviate lung oxidative damage induced by cr(vi). a high-performance liquid chromatography coupled with a mass spectrometer method was developed to separate and identify flavonoids in c. aurantium l. six flavonoids were identified, as (1) poncirin, (2) ... | 2013 | 22972417 |