| effects of interferon and adenine arabinoside treatment of hepatitis b virus infection on cellular immune responses. | fifteen patients with chronic hepatitis b were treated with adenine arabinoside (ara-a) or human leukocyte interferon (hli). cellular immune response to hepatitis b virus surface antigen and antigens prepared from herpes simplex virus, varicella zoster virus, and cytomegalovirus was measured by a lymphocyte blast transformation assay and an assay for interferon production. measurements were made before, during, and after antiviral treatment. unlike patients convalescing from acute hepatitis b, o ... | 1979 | 533259 |
| [detection of the canine herpesvirus in a case of whelp death]. | | 1979 | 538448 |
| studies on the temperature-dependent dna replication of the herpesvirus of the turkey in chicken embryo fibroblasts. | the development of cytopathogenic changes in chicken embryo fibroblasts infected with the herpesvirus of the turkey, strain pb-thvi, and the release of virus particles into the supernatant of infected cultures is accelerated at temperatures higher than 37 degrees c and is fastest at 41 degrees c, the normal body temperature of chickens. the growth rate of hvt in cef cultures was followed by determination of the number of virus genome equivalents within infected cells at various time intervals p. ... | 1979 | 541663 |
| pathogenicity of a marek's disease virus for chickens vaccinated with graded doses of herpesvirus of turkeys. | six different groups of one-day-old chickens were vaccinated with herpesvirus of turkeys (hvt) vaccine at doses of 0, 4, 16, 64, 256 and 1,024 plaqueforming units. at 9 days of age they were challenged with an acute strain of marek's disease herpesvirus (mdhv). gross and microscopic lesions in nerves and gonads were investigated and combined for quantitative expression of mdhv pathogenicity. including the microscopic lesions improved the accuracy of the hvt doses/mdhv response. the qualitative a ... | 1979 | 546406 |
| iontophoretic application of idoxuridine for recurrent herpes labialis: report of preliminary clinical trials. | in clinical trials on six patients the antiviral drug idoxuridine (stoxil) was applied by anodal (+) iontophoresis to 14 recurrent herpes labialis lesions. results were characterized by immediate relief of discomfort and swelling, rapid appearance and coalescence of vesicles, minimal or no spread of the lesions, and accelerated healing with minimal or no scab. these encouraging trials indicate that a full-scale, double-blind, controlled clinical study should be carried out to determine whether i ... | 1979 | 552584 |
| herpesvirus hominis (type 1) proctitis. | herpes proctitis from herpesvirus hominis type 1 is probably an underrecognized cause of rectal pain and inflammation. extreme anal pain and a purulent rectal discharge in a heterosexual man led to the appropriate diagnosis. clinicians should be more aware of herpes as a cause of proctitis. | 1979 | 553097 |
| replication of equine herpesvirus type 3: kinetics of infectious particle formation and virus nucleic acid synthesis. | the kinetics of equine herpesvirus type 3 (ehv-3) multiplication and of the synthesis of ehv-3 specific dna and rna were investigated. a one-step growth curve of ehv-3 in equine epithelial cells from a transitional cell carcinoma was characterized by: (1) a short eclipse period (4 h); (2) an exponential increase in infectious virus between 5 and 10 h post-inoculation; and (3) a slow, inefficient release of newly formed virus into the extracellular fluid. two hours after infection of cells with e ... | 1977 | 558280 |
| replication of equine herpesvirus type 1 and type 3: resistance to hydroxyurea and thymidine. | the replication of equine herpesvirus type 1 (ehv-1) and type 3 (ehv-3) was unimpeded in three different cell types-equine epithelial cells, equine fibroblasts, and mouse fibroblasts-which had been blocked in their capacity to synthesize host dna by 2.5 mm hydroxyurea (hu) or 2 mm thymidine (tdr). the rate of dna synthesis in uninfected or equine herpesvirus-infected cells in the presence of hu or tdr was measured by pulse-labeling cell samples with a labeled dna precursor at different times aft ... | 1978 | 563855 |
| treatment of genital infections with herpesvirus hominis. | | 1977 | 579479 |
| proventriculitis, "nakanuke" and reticuloendotheliosis in chickens following vaccination with herpesvirus of turkeys (hvt) | | 1977 | 588186 |
| how reliable is the morphological diagnosis of penile ulcerations? | material from 100 consecutive men who presented with penile ulcerations was tested for a variety of microorganisms. fifty-one patients had microorganisms identified that were considered primary pathogens. the laboratory data were compared with the clinical diagnoses and the diagnostic accuracy and index of suspicion calculated. the diagnostic accuracy for lesions due to treponema pallidum was 77.8%, herpesvirus hominis 62.9% and haemophilis ducreyi 33.3%, whereas the indexes of suspicion were 88 ... | 1977 | 594859 |
| vesicular lesions in adults due to echovirus 11 infections. | echovirus 11 was recovered from vesicular lesions in two adults. patient 1 had a severe disseminated vesicular exanthem. patient 2 had a mild vesicular enanthem. both were clinically suspected of having herpesvirus hominis lesions. serologic studies indicate that these viruses were similar to each other and also to the "u" prime strain. | 1977 | 596902 |
| application of the cell-free turkey herpesvirus vaccine by the aerosol route for the prevention of marek's disease in chickens. | in field trials approximately 300,000 birds were vaccinated against marek's disease (md) by aerosol spray with 1,000 to 5,000 pfu of cell-free hvt vaccine per chick. chicks were sprayed in the trays of the hatchers which still contained dust and down after hatching. prior to spraying, the incoming and outgoing air ducts were closed. the chicks were sprayed for 12--15 min. with hvt in 250 to 300 ml. of diluent, and after completion of spraying the chicks remained in contact with the aerosol for a ... | 1977 | 605103 |
| rational design of arabinosyl nucleosides as antitumor and antiviral agents. | the rational design of antitumor and antiviral agents must ultimately take advantage of biochemical differences between normal host cells and transformed cells. the initial experiments must be performed with subcellular or cellular model systems. for the studies with arabinosyl nucleosides we have chosen those enzyme systems, synthesizing dna and rna; being precursor analogues, the different arabinosyl nucleosides have been added in the triphosphate state to the different dna- and rna polymerase ... | 1977 | 612702 |
| isolation and characterisation of herpes virus from turkeys. | turkey herpesvirus (hvt) was isolated from the kidneys of 6 of 8 turkey poults from two flocks. the isolates were identified by syncytial-type of cytopathology, inhibition of plaque formation by 5-bromodeoxyuridine, formation of cowdry type a intranuclear inclusions in cell cultures, and presence of herpes-type virions in negatively stained preparations and thin sections of infected cell cultures. one of these isolates inoculated into chickens proved apathogenic over an observation period of 10 ... | 1977 | 614022 |
| a multicentered study of lysine therapy in herpes simplex infection. | lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312-1,200 mg of lysine daily in single or multiple doses. the clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine fa ... | 1978 | 640102 |
| antibodies to herpesvirus type 1 and type 2 among japanese cervical cancer patients. | antibodies to herpesvirus type 1 and type 2 were examined in 69 japanese females with cancer of uterine cervix, which included cases of cervical dysplasia (7 cases), carcinoma in situ (9 cases), and invasive carcinoma (53 cases), and 112 matched controls. the presence of antibodies to type 2 virus was 42% in cervical dysplasia, 11% in carcinoma in situ, and 28% in invasive carcinoma, while such was 15% in matched controls. mean antibody titer in log10 was 2.12 to type 1 and 1.65 to type 2 in wom ... | 1978 | 640320 |
| a bovine herpesvirus isolated from sheep. | a viral agent was isolated from the trachea of a lamb that was suffering from a respiratory disorder. the physical and chemical properties of the isolates are characteristic of the herpesvirus group. it contains dna in its virion, is ether sensitive, acid labile at ph 3.0 and heat labile at 56 degrees c after five minutes. the cytopathology observed provided further evidence of a herpesvirus isolate. the neutralization of the infectivity of the isolate with antiserum to bovine herpesvirus 1 is e ... | 1978 | 647461 |
| induction of delayed hypersensitivity to turkey herpesvirus in fowls. | delayed hypersensitivity, as determined by the wattle skin reaction, to turkey herpesvirus developed in chickens sensitised with the infected cell antigen. a significant increase in skin thickness occurred in the sensitised wattles as compared with the controls. | 1978 | 653123 |
| treatment of cutaneous herpesvirus hominis type 2 infection with 8-methoxypsoralen and long-wave ultraviolet light in guinea pigs. | treatment of cutaneous herpesvirus hominis type 2 infection in albino guinea pigs with 8-methoxypsoralen plus long-wave ultraviolet light was evaluated by clinical assessment and quantitative viral cultures. there was a statistically significant difference between the treated animals and the controls in relation to vesicular development, rate of healing, and viral titers. the treatment was effective after the appearance of lesions, when viral multiplication has already begun. | 1978 | 659920 |
| a biological perspective of slow virus infection and chronic disease. | sequential events characterize the interaction of viruses with parenchymal cells, and acute lytic infections of tissues and organs have broad biological attributes. a knowledge of these permits a keener understanding of persistent, intermittent herpesvirus infections and persistent, continuous respiratory virus infections. in addition to unique biochemical mechanisms which may permit the latter chronic infections to evolve, the roles of defective and mutant strains of virus, viral interference, ... | 1978 | 664641 |
| herpesvirus hominis endometritis in a young woman wearing an intrauterine contraceptive device. | | 1978 | 665740 |
| [disseminated herpesvirus hominis infection. a case report]. | a case of disseminated herpesvirus hominis (type i) in a 23-year-old white man with widespread eczema is reported. the grave prognosis of this disease is stressed. | 1978 | 675412 |
| pathogenicity of equine herpesvirus: in vivo persistence in equine tissue macrophages of herpesviuus type 2 detected in monolayer macrophage cell culture. | equine macrophages from the mammary glands of a yearling filly and an 18-year-old barren nonlactatind mare formed cell monolayers in continuous cultures. there was absence of viral cytopathic effect (cpe) in early cell culture passages. the cells from the early cell culture passages having no cpe failed to show evidence of virus or viral antigen by electron microscopic and immunofluorescence studies. foci of cpe first appeared in the monolayer cell cultures from the filly and the mare in the 3rd ... | 1978 | 697153 |
| frequency of anti-ag-4 antibody in patients with uterine cervical cancer and controls. | association of herpesvirus type-2 (hsv-2) with cervical cancer was studied from seroepidemiological viewpoint, using early antigen induced in hep-2 cells by hsv-2 4 hr after infection (ag-4). the ag-4 antibody was assayed by the microquantitative complement fixation method. antibody to ag-4 was respectively detected in 47% and 14% of cervical cancer patients and controls (p less than 0.001). there was a tendency of the antibody prevalence to increase with clinical stage. there was no correlation ... | 1978 | 710808 |
| marek's disease tumour-specific antigen induced by the herpesvirus of turkeys in vaccinated chickens. | the herpesvirus of turkeys, a supposedly apathogenic virus commonly used for vaccination against marek's disease, was found to induce marek's disease tumour-specific antigens on spleen and peripheral blood lymphocytes in vaccinated chickens. herpesvirus of turkeys may be able to induce the neoplastic transformation of lymphocytes and the consequential stimulation of an anti-tumour immune response may be an important component of vaccinal immunity. | 1978 | 716166 |
| antiviral activity of some beta-diketones. 4. benzyl diketones. in vitro activity against both rna and dna viruses. | the synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. the introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. the 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both rna and dna viruses. compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time ... | 1978 | 722755 |
| reversible effects on cellular metabolism and proliferation by trisodium phosphonoformate. | the antiviral compound trisodium phosphonoformate (pfa), which inhibits herpesvirus multiplication by 50% at a concentration of 10 mum, did not show any effects on macromolecular synthesis and cell proliferation in hela and human lung cells at this concentration. at the high concentration of 2 mm, pfa reduced dna synthesis to 50% after 1 h of treatment, whereas no effects could be seen on rna and protein synthesis. treatment for 24 h with 1 mm pfa inhibited both dna synthesis and cell proliferat ... | 1978 | 727763 |
| comparison of the therapeutic effects of five antiviral agents on cutaneous herpesvirus infection in guinea pigs. | cutaneous herpesvirus infection of guinea pigs has been evaluated as a model for testing antiviral compounds. six infected sites on each animal can be used independently for local treatment. the severity of the infection has been graded in a score system. the cumulative scores during infection and the time to healing can be used to determine antiviral effects. the effects of adenine arabinoside, cytosine arabinoside, iododeoxyuridine, ribavirin and phosphonoacetic acid on the cutaneous infection ... | 1978 | 736794 |
| [traumatic herpes hominis infection during rugby (herpes venatorum). a discussion of four cases]. | four cases of traumatic herpesvirus hominis infection of the skin sustained during rugby are described. attention is drawn to the importance of herpesvirus infection of the eye, both primary and secondary, whether from self-inoculation or exogenous infection. the diagnosis must be correct so that specific treatment with idoxuridine may be considered and harmful treatment with corticosteroids may be avoided. personal contact should be avoided during active infection. epidemiological data show tha ... | 1978 | 741300 |
| purification of channel catfish virus, a fish herpesvirus. | channel catfish virus was highly purified from host cells by precipitation with peg-6000 and isopycnic centrifugation in a metrizamide gradient. as calculated from reconstruction experiments, only 0.09 and 0.05% respectively of the host dna and the host proteins were recovered at the position of the viral band. the final recovery of infectivity was about 30%. electron microscopy showed mostly intact viral particles. | 1978 | 743643 |
| in vivo and in vitro studies on the effect of gentamicin sulfate on the efficacy of the turkey herpesvirus vaccine. | in vitro studies indicate that the titer of the cell-free or cell-associated turkey herpevirus (hvt) vaccine was not appreciably reduced when incubated with .1, .2, or .3 mg of gentamicin sulfate for up to 2 hr. however, the titer of both the cell-free and cell-associated hvt vaccines was reduced when incubated with .4 mg of gentamicin sulfate for 2 hr. however, in vivo studies show that the incidence of marek's disease (md) in chickens which were vaccinated with the cell-free or cell-associated ... | 1978 | 751032 |
| studies on resistance to marek's disease tumorigenesis: effect of immune stimulation, tumour-cell vaccines, and herpesvirus of turkeys on tumour immunity. | | 1978 | 751899 |
| herpesvirus-associated epidermal hyperplasia in fish (carp). | | 1978 | 751904 |
| on the etiological role of herpesvirus ovis in jaagsiekte. | serologically related ovine herpesviruses have been isolated independently by various workers in different countries from adenomatous lung tissue of sheep or cell cultures derived from it. although the disease can be transmitted with lung homogenates and with cell cultures, transmission attempts with virus alone failed. iudr treatment of tumour-cell cultures and co-cultivation or fusion with cells permissive for virus replication induced antigens which react with some sera from tumour-bearing an ... | 1978 | 751905 |
| intranasal vaccination against upper respiratory tract disease (u.r.d.) in the cat--ii. results of field studies under enzootic conditions in the netherlands with a combined vaccine containing live attenuated calici- and herpesvirus. | | 1978 | 757151 |
| prevention of marek's disease: a review. | marek's disease (md) is a highly infectious neoplastic condition of chickens caused by a herpesvirus. the virus is cell associated in tumors and in all organs except in the feather follicle where enveloped infectious virions egress from the body. from this source, infection is spread horizontally by the airborne route to the environment and to other chickens. vertical transmission from dam to offspring does not occur or at best is very rare. the nonpathogenic herpesvirus of turkeys (htv) is ubiq ... | 1976 | 766959 |
| the management of ocular herpesvirus infections. | the many treatment methods in current use for every known complaint only seem to aggravate the difficulty of treating ocular herpes simplex virus (hsv) infections, which are generally self-limited in the immunocompetent host. the cornea is already a somewhat immune-deficient tissue since its lack of blood vessels separates it partially from the host, and treatment with glucocorticoids, which are immunosuppressive, increases the risk of damaging complications such as scarring, prolonged morbidity ... | 1976 | 790617 |
| repetitive sequences in complete and defective genomes of herpesvirus saimiri. | two types of herpesvirus saimiri genomes can be isolated from purified virions: (i) the m genome is a double-stranded, liniear dna molecule with a mean contour length corresponding to 89 times 10-6 daltons. the m genome contains about 70% of unique sequences (light dna, 36% guanine plus cytosine) and 30% reiterated sequences (heavy dna, 71% guanine plus cytosine). (ii) the h genome is composed of heavy dna only and is more heterogeneous in size. the sequences in the h genome are up to 40-fold re ... | 1975 | 803569 |
| effect of maternal immunity against development of marek's disease and protective ability of vaccine. | experiments were conducted to determine the susceptibility of chicks to marek's disease and the protective effect of the vaccine prepared from herpesvirus of turkey (hvt) on progeny from dams infected with marek's disease virus (mdv), or hvt, or both when they were young. chicks from dams infected with mdv or hvt-mdv were protected from the development of marek's disease when challenged at 3 days of age. the degree of protection decreased when the time of challenge was delayed; no protection was ... | 1975 | 804667 |
| a killed vaccine derived from the oncogenic herpesvirus ateles. | a killed herpesvirus vaccine was prepared by inactivation of the oncogenic herpesvirus ateles (hva) with heat and formaldehyde. the vaccine proved safe in 9 marmosets (saguinus oedipus) during a period of 461 days. the vaccinated marmosets developed high titers of serum antibodies against hva and were resistant to 316 lethal dose 50 (ld50) cell-free hva; the nonvaccinated control monkeys died of malignant lymphoma. the 5 challenged monkeys are clinically well and have now been under observation ... | 1975 | 808642 |
| transformation in vitro with herpesvirus ateles. | continuous lymphoblastoid cell cultures were established after transformation invitro with hva of marmoset splenic or circulating lymphocytes. transformation was achieved by co-cultivating lymphocytes with lethally x-irradiated, hva-carrying cells (derived originally from tumour cells of a marmoset experimentally infected with hva) or by infecting marmoset lymphocytes with cell-free virus. tenty-eight continous cultures from 39 that underwent co-cultivation and two of four lymphocyte preparation ... | 1975 | 828140 |
| genital herpesvirus infection in a prepubertal girl. | an episode of acute vulvovaginitis which was found to be due to herpesvirus is described in an eight-year-old girl. the significance of such infections is discussed. | 1977 | 843482 |
| efficacy of 5,6-dihydro-5-azathymidine against cutaneous herpes simplex virus in hairless mice. | 5,6-dihydro-5-azathymidine, administered subcutaneously, was active both prophylactically and therapeutically against cutaneous herpesvirus infection of hairless mice. activity was comparable to that obtained with adenine arabinoside. | 1977 | 856033 |
| neuroretinitis associated with herpes simplex encephalitis in an adult. | a 48-year-old man who died of herpes simplex encephalitis had a bilateral papillitis at autopsy. intranuclear inclusion bodies were especially numerous within the ganglion cells and inner nuclear layer of the macula and consisted of typical virions by electron microscopy. contiguous spread from the brain to the eyes may have occurred via the optic nerves. clinically, the disk and retinal changes were misinterpreted as being caused by papilledema. papillitis should be included in the differential ... | 1977 | 868948 |
| failure of type 1 herpesvirus to develop resistance to ribavirin. | exposure (10 passages) of type 1 herpesvirus to ribavirin or idoxuridine in vero cells results in resistance to idoxuridine, but not to ribavirin. | 1977 | 883814 |
| morphogenic studies of herpesvirus and oncornavirus from leukemic and normal guinea pigs. | | 1977 | 885267 |
| malignant transformation of rat embryo cells by a herpesvirus isolated from l2c guinea pig leukemia. | | 1977 | 898672 |
| effect of pregnancy hormones on herpesvirus and other deoxyribonucleic acid viruses. | clinical impressions and observations of genital herpesvirus infections indicate that lesions are more persistent and more severe during pregnancy. several explanations are possible: an altered immune state, increased vascularity and blood flow, and/or increased viral infectivity due to increase in one or more hormones during pregnancy. studies presented here were directed toward investigating the latter possibility. herpesvirus, type 2, isolated from a genital lesion was titrated in wi-38 cells ... | 1977 | 900179 |
| disseminated herpesvirus hominis 2 infection following drug overdose. | fatal disseminated herpesvirus hominis type 2 infection developed in a 24-year-old woman with psychiatric disease. the primary site of virus entry appeared to be the upper respiratory tract, although the cervix and anus could have been primary sites. dissemination of infection was facilitated by steroid therapy. an endotracheal tube may have increased spread to the lower respiratory tract and an intrauterine device may have aided spread to the uterus. intranuclear inclusion body-bearing cells in ... | 1977 | 901088 |
| studies of turkey herpesvirus viremia in two strains of vaccinated chickens strain difference and effects of vaccine dose. | turkey herpesvirus (hvt) viremia was studied at 3-week intervals through 21 weeks of age in individual chickens of experimental (wsu-vs) and commercial strains (c-wl) of white leghorns vaccinated with graded doses of hvt. hvt viremia was consistently detectable in all wsu-vs birds through 21 weeks postvaccination (pv) regardless of vaccine dose employed, whereas the viremia could not be detected in some of the c-wl birds 9 to 15 weeks pv and thereafter. c-wl birds that lost detectable viremia re ... | 1977 | 907581 |
| herpesvirus-like particles in tumor cells of breast muscle of chickens with marek's disease. | tumors of the breast musculature of 4 chickens with marek's disease were examined by light and electron microscopy. by light microscopy, tumors were composed of lymphoid cells which had infiltrated and separated bundles of muscle fibers. by electron microscopy, there was margination of chromatin and duplication of the inner nuclear membrane in almost all neoplastic cells of breast tumors of all 4 chickens. in addition, in one chicken the nuclei of tumor cells contained naked herpesvirus-like par ... | 1977 | 907582 |
| efficacy of herpesvirus of turkeys vaccine against challenge with marek's disease tumor cells. | tests were made of the effectiveness of herpesvirus of turkeys (hvt) vaccine in preventing tumorigenesis following challenge with a neoplastically transformed marek's disease tumor cell line (msb-1). hvt vaccine prevented tumors due to msb-1 inoculation whereas 21.4% of unvaccinated controls had tumors. the results support, but do not prove, the theory that hvt acts through enhancement of cell-mediated immunity against mdv-transformed cells. the drawbacks of using msb-1 cells in this experiment ... | 1977 | 907584 |
| studies on cytopathogenic viruses from cats with respiratory infections. iv. properties of hemagglutinin in feline herpesvirus suspensions and receptors on feline erythrocytes. | | 1977 | 916471 |
| replication of herpesvirus of turkeys in chick fibroblasts. | an ultrastructural study of chick embryo fibroblasts infected with herpesvirus of turkeys (hvt) revealed that infection produced degenerative effects in the cells ranging from alteration of cellular structures to complete lysis of the cells. infection was indicated by margination of the nuclear chromatin, the presence of nuclear and cytoplasmic virions, destruction of mitochondria, loss of rough and smooth endoplasmic reticulum, and polykaryocytosis. viruses entered the cell by penetrating the c ... | 1976 | 934991 |
| replication of feline herpesvirus and feline calicivirus in cell and organ cultures. | virus titers from feline herpesvirus-infected feline tracheal organ cultures were higher than those from feline kidney cell cultures. the time for the development of peak viral yields was longer in organ culture as compared to cell cultures. feline tracheal organ cultures infected with feline calicivirus produced minimal viral titers. | 1976 | 937794 |
| viral infection as a cause of acute peripheral facial palsy. | among 51 patients with acute peripheral facial palsy, varicella-zoster virus was isolated from the cerebrospinal fluid (csf) in one case, and herpesvirus hominis from the nasopharynx in two cases. in 12 other cases, complement-fixing antibody or hemagglutination inhibition tests indicated a recent viral infection (varicella-zoster, seven; herpes simplex, one; cytomegalovirus, one; influenza type b virus, two; and mumps virus, one). one additional patient had clinical signs of herpes zoster oticu ... | 1976 | 938319 |
| studies on genetic and vaccination-induced resistance of chickens to lymphoid tumor transplants. 1. marek's disease tumor transplant (jmv). | six strains and 4 inbred lines of chickens that differed in susceptibility to marek's disease (md) were inoculated in the wing web with jmv when 5 weeks old. wing web tumors (wwt) developed in all strains and lines inoculated with low-passage jmv (jmv-l) but were largest in cornell strain s (highly susceptible to md). of 3 strains inoculated with high-passage jmv (jmv-h), only strain s had appreciable wwt development. seventy-five percent of the unvaccinated s strain chickens challenged with jmv ... | 1976 | 938376 |
| studies on genetic and vaccination-induced resistance of chickens to lymphoid tumor transplants 2. transmissible lymphoid tumor of olson. | transmissible lymphoid tumor (tlt) was inoculated in wing webs of five-week-old chickens of 6 strains. about half of the chickens of each strain had been vaccinated with turkey herpesvirus (hvt) one week before challenge in the wing web with tlt. tumors which developed at the site of inoculation usually reached maximum size within 2 weeks and then regressed. in some chickens, however, tumors developed in visceral organs and caused death in the 2nd through 5th weeks postinoculation. comparisons a ... | 1976 | 938377 |
| comparisons of cell-free and cell-associated marek's disease vaccines in maternally immune chicks. | cell-free and cell-associated marek's disease vaccines prepared from the tk/a isolate of the herpesvirus of turkeys (hvt) were compared to evaluate their relative effectiveness in protecting chicks with homologous maternal antibody. the influence of early challenge on protection was also investigated. although the higher susceptibility of cell-free hvt to neutralising antibody could be demonstrated in vitro, no significant difference between the two types of vaccine could be established in vivo ... | 1976 | 941388 |
| electron-microscopic study of herpesvirus macaca in human fibroblasts. | an electron microscopic study of the morphology of herpesvirus macaca, a serologically distinct infectious agent isolated from the leukocytes of rhesus monkeys, was performed. wi-38 fibroblast monolayers were infected with the virus and examined 18 days later. the morphology of herpesvirus macaca was, in general, typical of the herpesvirus group. enveloped virus particles observed via negative-stain technique had a diameter of 145-155 nm. an inner capsid composed of hexagonal capsomeres had a di ... | 1976 | 943215 |
| viral particles associated with malignant catarrhal fever in deer. | viral particles associated with malignant catarrhal fever in white-tailed deer (odocoileus virginianus) and axis deer (asix axis) are described. morphologically, the virus resembled the togaviruses and was unlike the herpesvirus which causes wildebeest-associated malignant catarrhal fever (snotsiekte). | 1976 | 945706 |
| virologic studies on cattle with naturally occurring and experimentally induced malignant catarrhal fever. | malignant catarrhal fever is an important disease of cattle and certain wild ruminants. it occurs in sporadic and epizootic forms in colorado cattle. specimens from 15 cattle with naturally occurring malignant catarrhal fever and 5 cattle with induced disease were examined for cell-free and cell-associated viruses. enteroviruses were isolated from leukocytes of 2 cattle with field cases of the disease. a herpesvirus with characteristics of the "movar"-type, isolated from the spleen of another st ... | 1976 | 949113 |
| preferential inhibition of herpes-group viruses by phosphonoacetic acid: effect on virus dna synthesis and virus-induced dna polymerase activity. | | 1976 | 960726 |
| persistent infection of cattle with the herpesvirus of malignant catarrhal fever and observations on the pathogenesis of the disease. | | 1976 | 963512 |
| experimental herpetic keratitis in the guinea pig. | a model of herpetic keratitis with type 1 herpesvirus hominis was established in the guinea pig. the administration of 10 mg triamcinolone acetonide subconjunctivally in both eyes resulted in an amelioration of the clinical course of the disease process, whereas 40 mg injected peritoneally did not. the possible pathophysiology of these responses is discussed. | 1976 | 982269 |
| biochemical studies of the maturation of herpesvirus nucleocapsid species. | | 1976 | 982808 |
| virucidal effect of certain chemical contraceptives on type 2 herpesvirus. | the virucidal effect of several chemical contraceptives was investigated and the findings are rrported. the supension of type 2 herpes simplex virus, containing 10(6) to 10(7) tissue culture infectious doses per 0.1 ml., was inactivated on exposure to five different chemical contraceptives. for quantitative estimates of virucidal effect, 10 per cent solutions of these chemical contraceptives were tested with an exposure time of 10 minutes at room temperature. the methods for determination of res ... | 1976 | 984103 |
| duck plague virus replication in muscovy duck fibroblast cells. | duck embryo fibroblast cell cultures from seven species of ducks were compared for virus yield, plaque quality, and sensitivity to infection by the duck plague herpesvirus (duck virus enteritis). muscovy duck and wood duck cells gave the best results for virus yield and plaque quality, but muscovies were considered superior because they are more available than wood ducks. pintails and lesser scaup gave the poorest results, and pekin duck, black duck, and redhead duck were intermediate. a growth ... | 1976 | 986808 |
| induction of tumors by a guinea pig herpesvirus-transformed hamster cell line. | syrian hamster embryo cells that had been transformed in vitro by guinea pig herpes-like virus (gphlv) were found to be oncogenic when inoculated into hamster sc or ip. of 71 animals inoculated, 30 showed tumors at the site of inoculation. tumors appeared 4-23 weeks after inoculation of the transformed cells at passage 37 or higher. inbred and randombred hamsters of all ages were susceptible. upon microscopic examination the tumors were characterized as fibrosarcomas. the cultured hamster tumor ... | 1976 | 994218 |
| anorectal herpesvirus hominis infection in men. | thirteen cases of anorectal herpesivirus hominis infection in male homosexuals are described. symptoms included pruitus ani in 11 cases, while 7 noticed intense and pain. change of bowel habits and anal discharge were not presenting symptoms in the majority. none had generalized complications. inguinal lymphadenopathy, a vesicular eruption, and superficial ulceration around the anal margin were commonly found. some developed vesicular spread to the natal cleft. treatment with cotrimoxazole to pr ... | 1976 | 1010770 |
| field trials with lyophilised herpesvirus of turkeys vaccine against marek's disease in layer and broiler rearing flocks. | the safety and immunogenicity of commercial lyophilised herpesvirus of turkeys (hvt) vaccine against marek's disease (md) was evaluated in 19 field trials involving 76,848 vaccinated and 87,590 control chickens. in the first series of 11 trials involving one commercial vaccine at a dose of 536 plaque forming units (pfu) there was a significant reduction in the incidence of md (p less than 0.001) and in total mortality (p less than 0.001) from 0 to 18 weeks due to vaccination and the overall prot ... | 1976 | 1021114 |
| herpesvirus and multiple sclerosis. | | 1976 | 1028259 |
| epidemiology and aetiology of cancer of the uterine cervix including the detection of carcinogenic n-nitrosamines in the human vaginal vault. | cancer of the uterine cervix occurs with high frequency in black females of several populations of southern africa. it accounts for 40-50% of all cancers in black females in the johannesburg area and for over 40% of those in women in the rural lowveld area of the transvaal. the aetiology of this cancer has several distinct features, almost all of which concern some or other aspect of coitus. age at first coitus and at first marriage, and promiscuity, are very strongly associated with the develop ... | 1975 | 1080296 |
| infection of human and rhesus lymphoblastoid cells with herpesvirus macaca. | the interaction between herpesvirus macaca and lymphoblastoid cells grown in continuous culture, or purified from rhesus blood, was studied as a model for latent or chronic herpesvirus infection of leukocytes. continuous lymphoblastoid cell lines infected in vitro were pa3, a human cell line with bone-marrow derived (b)-lymphocyte characteristics; lm/dm, a rhesus cell line with b-lymphocyte characteristics; and molt-4, a human cell line with thymus-derived (t)-lymphocyte characteristics. a disti ... | 1975 | 1082329 |
| virologic and serologic studies of zoo birds for marek's disease virus infection. | one hundred and eleven zoo birds representing 49 species in 14 orders were examined for marek's disease (md) herpesvirus (mdhv) infection. mdhv was isolated from 10 birds, all belonging to genus gallus. the precipitating antibodies against mdhv were demonstrated only in the gallus birds, when 51 selected birds including 34 galliformes and 17 other birds representing 12 species from nine orders were examined. the 10 mdhv isolates all induced morphologically similar plaques in cell cultures closel ... | 1975 | 1091554 |
| antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in ibadan, nigeria. | carcinoma of the cervix is by far the commonest gynecologic malignancy seen in ibadan, nigeria. in a study aimed at investigating the role of herpesvirus type 2 (ht-2) in its pathogenesis, antibodies to ht-2 were detected by immunofluorescence above a titer of 640 in 31 (70.5 percent) of 44 women with invasive carcinoma of the cervix as compared with five (11.1 percent) of 45 healthy women of the same age group. analysis according to histologic types of growths showed that 31 (83.8 percent) of 3 ... | 1975 | 1106197 |
| effect of povidone-iodine on herpes genitalis. | ten patients with vulvovaginal and cervical herpesvirus infections were treated with a regimen of external and intravaginal povidone-iodine preparations. in all but 1 case, the expected duration of symptoms and healing time were shortened. the response of cervical lesions was especially remarkable. the findings of this pilot study warrant further controlled clinical investigation. | 1975 | 1113955 |
| viremic responses of genetically susceptible and resistant chickens to experimental infection with acute, mild, or both strains of marek's disease herpesvirus. | the development and persistence of viremia were followed in two lines of single-comb white leghorns: one experimental line (wsu-vs) highly susceptible, and one commercial line (c-wl) relatively resistant to marek's disease(md). in the resistant c-wl chicken, viremia with a mild strain of md herpesvirus (mdhv) persisted in all viremic birds through 8 weeks postinoculation (pi), while viremia with an acute strain of mdhv did not, resulting in a decrease in number of viremic birds after 2 weeks pi. ... | 1975 | 1120039 |
| neutralising antibody to herpesviruses dervied from wildebeest and hartebeest in wild animals in east africa. | the sera of 728 game animals, collected in east africa, were tested for neutralising antibody to a strain (wc11) of wildebeest herpesvirus, which is an important cause of malignant catarrhal fever of cattle. in addition, 290 of these sera were tested for neutralising activity against a closely related herpesvirus (k/30) from hartebeest (alcelaphus sp.). antibody was frequently present in three species of the subfamily alcelaphinae (wildebest, hartebeest and topi) and one of the subfamily hippotr ... | 1975 | 1144919 |
| herpesvirus hominis infection in newborn mice: comparison of the therapeutic efficacy of 1-beta-d-arabinofuranosylcytosine and 9-beta-d-arabinofuranosyladenine. | intranasal inoculation of newborn mice with herpesvirus hominis type 2 provides an experimental infection that closely resembles disseminated herpesvirus infection of human newborn infants. after inoculation of mice, the virus multiplies in the respiratory tract and is disseminated through the blood to the liver and spleen and to the brain by both a viremia and nerve route transmission. although therapy with 1-beta-d-arabinofuranosylcytosine (ara-c) did not reduce final mortality, it did increas ... | 1975 | 1147590 |
| recovery of a new herpesvirus from the ground squirrel (citellus citellus). | a new herpesvirus recovered from the kidneys of mature ground squirrels (citellus citellus) produced an effect in tissue culture cells resembling that of herpesviruses, including the formation of multinucleated syncytia and type a intranuclear inclusions. the isolate caused latent infection in the natural host, but it proved fatal for intracerebrally inoculated suckling mice and it produced pocks on the chorioallantoic membrane of embryonated eggs. electron-microscopic examination of infected ce ... | 1975 | 1153219 |
| viral carcinogenesis in a pronephric cell line. an ultrastructural study. | herpesvirus recovered from cell fractions of the spontaneous lucké renal tumor of adult rana pipiens were used to infect a cell line derived from pronephroi of the same species. viruses and virus-associated structures previously found in the primary renal tumor were observed, including nuclear inclusions of capsids with single or double membranes and capsids with nucleoids often within nuclear sacs. embedded within the clumped and marginated chromatin were 55-nm tubular elements and associated u ... | 1975 | 1155580 |
| herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid. | intranasal inoculation of newborn mice with herpesvirus hominis (hvh) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(i:c)] significantly increased the mean survival time and markedly altered the pathogenesis of the infection. no significant protection against final mortality was observed. poly(i:c) therapy completely inhibited detectable viral replication in all target o ... | 1975 | 1155920 |
| the ultrastructure of lymphoblastoid cell lines from marek's disease lymphomata. | the ultrastructure of two lymphoblastoid cell lines derived from marek's disease lymphomata has been studied. the cells varied from 5 to 12 mum in diameter and had large round or oval nuclei. a nucleolus was occasionally present and about 3% of cells showed projections of the nuclear envelope. the cytoplasm contained many ribosomes and several mitochondria but endoplasmic reticulum was sparse. a small number of cells contained annulate lamellae and crystalline structures were occasionally seen. ... | 1975 | 1156510 |
| effects of strain of chickens and vaccination with turkey herpesvirus on marek's disease and lymphoid leukosis in breeding stocks. | 1. a total of 3236 females from eight meat-type strains, half of which were vaccinated for marek's disease (md), and 11,193 leghorn females from ten strains, all vaccinated for md, were adventitiously exposed to md and lymphoid leukosis (ll) viruses and observed to 392 and 497 d of age, respectively. 2. in the meat-type birds, vaccination reduced total mortality from 43-4% to 27-1% and mortality due to md from 16-4% to 5-4% but did not affect mortality and ll (2-9% and 3-4%). 3. in the vaccinate ... | 1975 | 1156921 |
| a comparison of the efficacy against marek's disease of cell-free and cell-associated turkey herpesvirus vaccine. | one-day-old white leghorn and broiler chicks with maternal antibody to turkey herpesvirus (hvt) were vaccinated with 300 or 1,000 plaque-forming units (pfu) of cell-free or cell-associated hvt vaccine and challenged with virulent marek's disease virus (mdv) by contact exposure. broiler chicks receiving 300 pfu of cell-associated hvt had a 3.3% incidence of md lesions, whereas only 2.0% of those receiving 1,000 pfu had macroscopic lesions. broiler chicks vaccinated with 300 pfu of cell-free vacci ... | 1975 | 1164319 |
| immunisation of cattle against the herpesvirus of malignant catarrhal fever: failure of inactivated culture vaccines with adjuvant. | attempts were made to immunise cattle against the herpesvirus of malignant catarrhal fever by inoculating living or formalinised preparations of the agent, propagated in cell cultures and combined with freund's incomplete adjuvant. high and persistent levels of virus-neutralising antibody were regularly demonstrable, especially following two intramuscular inoculations at an interval of six to eight weeks. in spite of this no protection was demonstrable against parenteral challenge with virulent ... | 1975 | 1166120 |
| characterization of three species of nucleocapsids of equine herpesvirus type-1 (ehv-1). | | 1975 | 1167720 |
| immunoferritin and immune electron microscopic study of bovine herpesvirus strain dn-599. | intracellular antigens of strain dn-599 bovine herpesvirus were detected in the cytoplasm and the nucleus of infected bovine embryonic kidney cells by the indirect immunoferritin (if) technique. specific tagging was observed in viral envelope and capsids. aggregates of viral particles heavily coated with antibody were seen by immune electron microscopy (iem). | 1975 | 1167771 |
| neonatal risk following late gestational genital herpesvirus hominis infection. | five women developed genital herpesvirus hominis (herpes simplex virus) infection beyond 32 week's gestation. two of the women had fresh vesicular lesions at parturition. the five infants were delivered per vaginum at term and escaped subsequent overt herpesvirus hominis infection, although a scalp lesion in one infant was dismissed as inconsequential and disappeared without virologic study. examination of the infants two months to four years after birth failed to detect sequelae of possible sub ... | 1975 | 1168410 |
| tubular structures in rabbit kidney cells infected with herpesvirus cuniculi. | | 1975 | 1180871 |
| [some scientists of upjohn use experimental animals to study herpesvirus type 2]. | | 1975 | 1187007 |
| isolation and characterization of a herpesvirus from wild turkeys (meleagris gallopavo osceola) in florida. | viral agents producing both a syncytial-type cytopathic effect and type a intranuclear inclusion bodies in vitro were isolated from the kidneys of five of 10 wild turkeys. a plaque assay system for viral infectivity was developed and used to characterize one of the wild turkey viruses (wtv). wtv replication was inhibited by 5-bromodeoxyuridine, indicating the virus contained dna as its genetic material. virus infectivity could be transferred only as viable whole cell preparations; one cycle of r ... | 1975 | 1195504 |
| effect of povidone-iodine on herpesvirus type 2, in vitro. | povidone-iodine solution (betadine) at concentrations of 0.167% (v/v) reduced the end-point titers of strain e.m. herpesvirus, type 2, by more than 99.99%. even at concentrations of 0.0167% (v/v), povidone-iodine solution reduced the titers by 92%. the iodine solution, per se, had no effect on cultured human fibroblasts in concentrations of 1.67% (v/v). | 1975 | 1196555 |
| chlamydial infection in women with cervical dysplasia. | the prevalence of antibodies to chlamydiae, particularly to tric (trachoma-inclusion conjunctivitis) agents, was studied in women with cervical dysplasia and in women attending selected clinics (obstetrics, cancer-screening, and gynecology). in addition, attempts were made to isolate tric agents and herpesviruses from the cervices of these women. tric agent recovery rates 4.1 per cent for women with dysplasia, 5.4 per cent for pregnant women, 7.8 per cent in the women's clinic, and 0.8 per cent ... | 1975 | 1200069 |
| ultrastructural studies of semen abnormalities and herpesvirus associated with cultured testicular cells from domestic turkeys. | abnormal cells and macrophages found in white and yellow turkey semen were studied by electron microscopy. yellow semen contained many abnormal cells, most of which were large and round or smaller and ellipsoidal. it was concluded that they were aberrant spermatids, with differentiation being more complete in the smaller cells. only a few cells of the smaller type were detected in normal white semen. macrophages were occasionally seen in white semen but were numerous in yellow semen. phagocytic ... | 1975 | 1206622 |
| isolation and in vitro characterization of a herpesvirus from ground squirrels (citellus sp). | a viral agent was isolated from ground squirrel primary kidney cultures which presented a spontaneous cell layer alteration. the cultural, morphologic, and physico-chemical characteristics of the agent indicated that it belongs in the herpesvirus group. the isolate presented a narrow in vitro cell host range, growing best in marmoset monkey, owl monkey, rabbit, and hamster kidney cultures and poorly in vero and dog fetal lung cells. the agent is readily released from infected cells, a fact which ... | 1975 | 1207043 |
| characteristics of an ovine herpesvirus associated with pulmonary adenomatosis (jaagsiekte) in sheep. | the isolation of an ovine herpesvirus from a cell culture of an adenomatous sheep lung is reported, confirming previous observations of a possible association of a herpesvirus with this tumour. some growth properties and morphological characteristics of the virus are described, as well as serological data supporting a possible relationship between tumour and virus. attempts to produce jaagsiekte by intratracheal injection of virus into lambs were unsuccessful, suggesting that a second factor may ... | 1975 | 1209391 |
| prevention of herpes keratoconjunctivitis in rabbits by silver sulfadiazine. | silver sulfadiazine, at a concentration of 10 mug/ml when applied immediately after infection by herpesvirus hominis, prevented the development of acute herpetic keratoconjunctivitis in rabbits. the efficacy was inversely related to the size of inoculum. subclinical infections were observed in the drug-treated eyes. | 1975 | 1211919 |