Publications

interaction of adenine arabinoside and host defense factors in experimental infections due to herpesvirus hominis.	the role of host immune functions in relation to the antiviral effects of adenine arabinoside (ara-a) and/or humoral antibodies in herpesvirus hominis infection was studied in four different mouse models (newborn swiss mice, three-week-old swiss mice, athymic nude [nu/nu] mice, and phenotypically normal [nu/+] littermates of nude mice). although the overall beneficial effects afforded by the administration of ara-a and/or humoral antibodies were similar, the degree of protection varied among the ...	1977	191543
lack of association between defective delinquents and antibody of herpesvirus hominis.	several groups have reported a relation between herpesvirus hominis infection and certain psychiatric disorders. we have investigated herpes antibody levels in chronic criminal offenders who were diagnosed as defective delinquents and in criminals who were not defective delinquents. we found no difference in the frequency of titers of herpesvirus type i or type 2 antibody in these groups.	1977	191768
in vitro suppression of herpesvirus saimiri replication by phosphonoacetic acid.		1977	191845
experimental induction of feline viral rhinotracheitis virus re-excretion in fvr-recovered cats.	the re-excretion of feline viral rhinotracheitis (fvr) virus (feline herpesvirus i) by fvr-recovered cats is recorded both spontaneously and following a variety of stimuli, namely, corticosteroid administration, change of housing, and parturition and lactation. at least 27 of 33 (82%) fvr-recovered cats studied were shown to be viral carriers. the carrier state was characterised by periods of viral latency interspersed with episodes of viral shedding. administration of 0-75 mg dexamethasone trim ...	1977	191978
immunoprecipitation of herpes simplex virus type 1 antigens with different antisera and human cerebrospinal fluids.	rabbit convalescent and hyperimmune sera, human patient and blood donor sera, as well as cerebrospinal fluids of humans with herpes simplex virus encephalitis all recognize similar major antigenic components in herpes simplex virus infected rabbit or human cells as shown by electrophoretic analysis of immunoprecipitates. besides the main glycoproteins with an apparent molecular weight of 100,000 (peak i) the antisera precipitate glycoproteins in a region of an apparent mol. wt. of 60,000--80,000 ...	1977	192180
activation of latent herpesvirus hominis in explants of rabbit trigeminal ganglia: the influence of immune serum.	more than fifty albino rabbits were inoculated into the right scarified cornea with 10(7) pfu of the kupka strain of human herpes virus type 1 (hhv-1). at intervals ranging from 4--280 days post infection (p.i.), both gasserian ganglia, both trigeminal nerve trunks and pieces from brain stem and from both corneas were explanted. activation of the latent hhv-1 was found mainly in the homolateral ganglion tissue, but also in explants originating from the opposite ganglia. within 24--72 hours, prio ...	1977	192182
venereal factors in human cervical cancer: evidence from marital clusters.	all caucasian women in a large eastern city who developed pathologically confirmed cervical cancer between 1950 and 1969 are being prospectively followed in an epidemiological test of the venereal hypothesis of cervical carcinogenesis. we are attempting to identify all men who were married to these probands at any time prior to the date of their cancer diagnosis. the ultimate objective is the identification of all the other wives of the proband husbands in order that their risk of cervical cance ...	1977	192439
mechanisms of resistant of herpesviruses: comparison of the effectiveness of different cell types in mediating antibody-dependent cell-mediated cytotoxicity.	enriched populations of polymorphonuclear leukocytes (pmn) and macrophages obtained from the mammary gland and of granulocytes (pbg) and lymphocytes (pbl) prepared from peripheral blood of the same animal were compared for their ability to mediate antibody-dependent cell cytotoxocity against antibody-sensitized infectious bovine rhinotracheitis virus-infected target cells (ibr-gbk) and antibody-sensitized chicken erythrocyte targest (crbc). the order of effectiveness was pmn leads to macrophages ...	1977	192672
effect of water temperature on a herpesvirus infection of sea turtles.	the role of water temperature in the induction and maintenance of a dermal herpesvirus infection (gray-patch disease) of young, green sea turtles (chelonia mydas) was studied under carefully controlled experimental conditions, in which the influence of other recognized stress factors was negligible. a nimals that were subjected to a gradual temperature increase from 25 to 30 degrees c, with subsequent maintenance at 30 degrees c, and those that were abruptly shifted from water at 25 degrees c to ...	1977	192673
antigenic relationships among several simian varicella-like viruses and varicella-zoster virus.	cross-neutralization and complement fixation tests demonstrated the immunological identity of the delta herpesvirus, the 592s virus, the liverpool vervet monkey virus, the herpesvirus of patas monkeys, and the medical lake macaque virus. these viruses were isolated from diverse outbreaks of varicella-like disease in simians and from various simian species. all of the simian viruses were shown to be related to human varicella-zoster (v-z) virus, as evidenced by the fact that immunization of monke ...	1977	192676
infectious causes of equine respiratory disease on ontario standardbred racetracks.	upper respiratory disease has been a serious problem in standardbred horses on racetracks in ontario, with outbreaks occurring once or twice annually in late winter and early spring seasons. to determine the causes of these epidemics, a 3-year investigation was carried out in which nasal swabs and serum samples were obtained at intervals from apparently healthy horses and from horses suffering from upper respiratory disease. the nasal swabs were used to isolate bacteria and viruses. the serum sa ...	1977	192757
comparative complement fixation and serum neutralization antibody titers to herpes simplex virus type 1 and herpesvirus simiae in macaca mulatta and humans.	the serological relationship of herpes simplex type 1 virus and herpesvirus simiae was studied. antibody titers to these viruses were determined in 163 macaca mulatta sera and 67 human sera by serum neutralization (sn) and complement fixation (cf) tests. both groups of sera were also tested by cf with envelope and capsid antigens of herpes simplex type 1. by sn, the majority of the monkeys and all of the humans had a higher titer to herpes simplex type 1 than to h. simiae. by cf, with crude anti ...	1977	192762
suppressed response to interferon inducation in mice infected with encephalomyocarditis virus, semliki forest virus, influenza a2 virus, herpesvirus hominis type 2, or murine cytomegalovirus.	mice infected with encephalomyocarditis virus, semliki forest virus, influenza a2 virus, herpesvirus hominis type 2, or murine cytomegalovirus developed a state of hyporeactivity to interferon induction. in general, the capacity of infected animals to produce interferon in response to inducers became progressively impaired during the course of infection. the severity and time of onset of hyporeactivity, however, were dependent upon the inducer and the nature of the viral infection. during viral ...	1977	192804
genital herpesvirus homonis infection in mice. ii. treatment with phosphonoacetic acid, adenine arabinoside, and adenine arabinoside 5'-monophosphate.	genital infection of mice with herpesvirus hominis type 2 provides an experimental model for screening potential antiviral chemotherapeutic agents before clinical trials in humans. intravaginal treatment with phosphonoacetic acid (at a dose of 500 mg/kg in saline or as a 5% cream) initiated 3 hr after inoculation with h. hominis type 2 completely inhibited viral replication in the genital tract and prevented subsequent mortality. although therapy initiated 24-72 hr after infection significantly ...	1977	192805
cellular immune responses to herpesviruses during treatment with adenine arabinoside.	thirteen patients severely infected with herpesvirus were treated with intravenous adenine arabinoside (ara-a), and two patients received placebo therapy. blastogenic and cytotoxic responses specific for the virus infecting each patient were determined before, during, and after treatment. blastogenic responses to three mitogens (phytohemagglutinin, pokeweed, and concanavalin-a) were examined, as were titers of viral antibody. in vitro responses during and after treatment with ara-a were unchange ...	1977	192808
immunomodulation of host resistance to experimental viral infections in mice: effects of corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin.	resistance to a representative group of experimental virual infections in mice was significantly enhanced by nonspecific modulation of host defense mechanisms. corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin were effective in enhancing host resistance. animals treated seven to 10 days before inoculation of virus were protected against a lethal infection with herpesvirus hominis type 2, encephalomyocarditis virus, murine cytomegalovirus, or semliki forest virus. the pro ...	1977	192811
thymidine transport in herpesvirus hominis type 1 and 2 infected bhk 21 cells.	increase of dthd-uptake 4 to 12 h after infection of bhk or primary rabbit kidney cells with herpesvirus hominis of type 1 or 2 can be considered as an early function of the virus genome, because the presence of cyd-ara does not prevent the increase of uptake. however, increase of uptake can be prevented by addition of actinomycin d and cycloheximide early in the synthetic cycle. two modes of uptake have been differentiated by kinetic analysis: at low substrate concentration dthd is taken up by ...	1977	192842
rna and protein synthesis in herpesvirus-infected cells.		1977	192850
lamella-particle complexes in nuclei of owl monkey kidney cells infected with herpesvirus saimiri.	a complex consisting of ribosome-like particles and a striated lamella occurring in stacked, tubular, and twisted ribbon-like configurations was observed in the nuclei of confluent monolayer cultures of primary owl monkey kidney cells infected with herpesvirus saimiri. they were similar to the cytoplasmic cylindroid structures seen in some human leukemias and in the lymphoma of the northern pike.	1977	192900
cellular immunity and herpesvirus infections in cardiac-transplant patients.	we observed severe infection with herpes simplex virus in cardiac-transplant patients despite their high serum antibody levels to this virus. therefore, we sought to correlate clinical susceptibility to two herpesvirus (simplex and zoster) infections with specific cellular immunity, assessed by the transformation and interferon responses of peripheral blood mononuclear cells to heat-inactivated antigens. transformation and interferon response to herps simplex virus was maximally depressed immedi ...	1977	193008
immune surveillance--a powerful mechanism with a limited range.	there is excellent evidence for the belief that immune surveillance mechanisms prevent the outgrowth of potentially neoplastic cells induced by horizontally transmitted, ubiquitous, potentially oncogenic viruses, indigenous to natural populations. polyoma virus in mice, marek's disease in the chicken, herpesvirus saimiri in the squirrel monkey, and the epstein-barr virus in man are examples. there is much less evidence for immune surveillance against chemically induced tumors. it is argued that ...	1976	193016
induction of deoxycytidine deaminase activity in mammalian cell lines by infection with herpes simplex virus type 1.	herpes simplex virus type 1 induces deoxycytidine deaminase (cytidine/deoxycytidine aminohydrolase, ec 3.5.4.5) activity when it lytically infects a number of mammalian cell lines. the deaminase activity is induced in a mouse cell line that is deficient in this enzyme. the induction of the enzyme in this mutant cell line does not occur in the presence of actinomycin d and the induced enzyme is more thermolabile than the enzyme of the wild-type mouse cell line. furthermore, a new deoxycytidine de ...	1977	193115
regulation of herpesvirus macromolecular synthesis. v. properties of alpha polypeptides made in hsv-1 and hsv-2 infected cells.		1977	193259
the cell-free synthesis of herpesvirus-induced polypeptides.		1977	193273
herpesvirus group antibodies in children with hodgkin's disease.	during the period of three years ((1972-1974), serum samples from 60 patients (children and adolescents) with lympho-hematopoietic system diseases were examined for antibodies to all four human herpesviruses. among these were 26 active hodgkin's disease (ahd) patients and 6 hd patients with a minimum five years' remission. simultaneously matched controls (age, sex) of ahd patients were examined. antibody levels against the viral capsid antigen of epstein-barr virus (ebv/vca) in ahd patients were ...	1977	193463
antibody-dependent cellular protection against herpes simplex virus dissemination as revealed by viral plauqe and infectivity assays.	mouse nonimmune peripheral blood lymphocytes (pbl) plus antibody to herpes simplex virus inhibited virus dissemination in herpes simplex virus-infected 3t3 cell culture as revealed by development of viral plaque, size of immunofluorescent foci, appearance of polycaryocytes, and viral infectivity appearing in the culture. these nonimmune pbl did not act alone in inibiting virus dissemination, but did act synergistically in combination with antibody. the ratio of pbl to target monolayer cells need ...	1977	193792
the role of neutrophils in antiviral defense--in vitro studies on the mechanism of antiviral inhibition.	highly enriched populations of bovine neutrophils were added, in the presence of antiviral antibody, to herpesvirus-infected bovine cell cultures. a cell dose-dependent reduction in virus-induced cytopathology was observed. the mechanism of inhibition was presumed to be mediated by a subcellular neutrophil product and not the result of either direct cytotoxicity or antibody-dependent cell-mediated cytotoxicity (adcc). thus, inhibition of comparable magnitude was observed when neutrophils and vir ...	1977	193989
inclusion body disease of falcons (herpesvirus infection) in an american kestrel.	postmortem examination of a captive-bred american kestrel (falco sparverius) showed numerous white necrotic foci 1-2 mm in diameter throughout the liver and spleen. the results of light and spleen. the results of light and electron microscopic studies and experimental transmission to a captive american kestrel and a barred owl (strix varia) suggests a herpesvirus similar to those dsecribed for owls and other falcons in the u.s. this is the first report of a naturally occurring case of inclusion ...	1977	194064
genital herpes and type 1 herpesvirus hominis.		1977	194070
sero-diagnostic aspects of feline herpesvirus infection.		1977	194079
simultaneous isolation of herpesvirus hominis type 2 and cytomegalovirus from the genital tract of a woman.	herpesvirus hominis and cytomegalovirus are closely related deoxyribonucleic acid viruses which have been isolated from the genital tract. this report describes the simultaneous isolation of herpesvirus hominis type 2 and cytomegalovirus from the genital tract of a woman preceded by the isolation of cytomegalovirus from the semen and a probable herpetic penile infection in her sexual partner.	1977	194344
replication of herpesvirus dna. i. electron microscopic analysis of replicative structures.		1977	194406
replication of herpesvirus dna. ii. sedimentation characteristics of newly synthesized dna.		1977	194407
[studies on herpesvirus cuniculi. i. virus isolation and antibody response in rabbits with experimental infection (author's transl)].		1976	194410
pacheco's parrot disease of psittacine birds.	pacheco's parrot disease was identified as the cause of death of 3 psittacine birds at an aviary. confirming a previous report, a herpesvirus was found to be the etiologic agent. the virus induced mortality in embryonated chicken eggs and budgerigars. the virus was characterized by electron microscopy, filtration experiments, and ether-sensitivity. hepatic lesions in chick embryos and budgerigars were similar by light- and electron-microscope studies. naked and enveloped nucleocapsids were seen ...	1977	194568
epidemiologic study of prostatic cancer: preliminary report.	in a preliminary report on a small fraction of the projected subject population, some evidence in support of both sexual activity and venereal transmission hypotheses is accumulating. prostatic cancer cases, in contrast to hospitalized and/or neighborhood controls, are beginning to show greater proportions of selected sexual activities compatible with venereal transmission of an infectious agent, such as number of sexual partners, use of prostitutes, prior venereal disease, and genital infection ...	1977	194689
[herpesvirus antibodies in hodgkin's disease and some lympho-hematopoietic diseases in children and adolescents].		1977	194715
protective immunity in equine herpesvirus type i infection of hamsters.		1977	194753
antiviral activity of some beta-diketones. 1. aryl alkyl diketones. in vitro activity against both rna and dna viruses.	the discovery that 4-[3-ethyl-6-[(3,4-methylenedioxy)phenyl]-3-hexenyl]-3,5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure--activity study to establish the criteria for optimum activity. modification of the bridge included removal of the ethyl group and reduction of the double bond. the heptanedione was replaced with hexanedione and pentanedione with a minimal effect. the effect of replacing the heptanedione with beta-keto esters and monoke ...	1977	195054
antiviral activity of some beta-diketones. 2. aryloxy alkyl diketones. in vitro activity against both rna and dna viruses.	a series of aryloxy alkyl diketones ii was synthesized and screened in vitro for antiviral activity. the effect of various substituents on the phenyl ring, as well as the length of the alkyl bridge, was examined to establish the requirements for optimum activity. one of the most active members of the series, 4-[6-(2-chloro-4-methoxy)phenoxy]hexyl-3,5-heptanedione (56), exhibited a high level of activity against both dna and rna viruses in both the tissue culture and organ culture screens and was ...	1977	195055
herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys.	four of 5 howler monkeys (alouatta caraya) experimentally infected with herpesvirus saimiri (hvs) developed a rapidly fatal malignant lymphoma accompanied by peripheral t-cell lymphocytosis. hvs was isolated from fresh and tissue cultured blood and tissue lymphocytes and from cell cultures derived from nonlymphoid organs. humoral antibodies against hvs-induced antigens were detected in the sera of the animals. the in vitro response of the peripheral blood lymphocytes to mitogenic stimulants was ...	1977	195067
lymphoproliferative diseases of fowl: jm-v leukemic lymphoblasts in cell culture.	jm-v leukemic lymphoblasts were established in cell culture. the cultured cells (jm-vlc cells) were transplantable in young chicks and produced a disease indistinguishable from jm-v lymphoblastic leukemia as initiated by whole-blood inoculation. jm-vlc cells maintained a normal female karyotype through 13 passages in rhode island red cockerels. with the use of jm-v antisera and antisera from birds with naturally occurring marek's disease (md), specific antigens were detected on the surfaces of l ...	1977	195070
regulation of herpesvirus macromolecular synthesis. vi. synthesis and modification of viral polypeptides in enucleated cells.	cells were enucleated with cytochalasin b after infection with herpes simplex virus 1. when protein synthesis was blocked by cycloheximide from the time of infection, mrna for viral alpha-infected cell polypeptides (icp) 4, 0, and 27 accumulated in the cytoplasm and was expressed after the removal of both drug and nucleus. a host protein, icp 22, whose synthesis is stimulated in intact cells, was not made, and viral protein icp4, which is normally modified to a form that migrates more slowly in ...	1977	195087
replication of herpesvirus dna. iii. rate of dna elongation.	the rate of pseudorabies virus dna elongation was measured by three different techniques: density shift experiments, radioautography examined by light microscopy, and radioautography examined by electron microscopy. the rate of the fork movement at 37 degrees c was estimated to be approximately 1 micron/min.	1977	195088
episomal viral dna in a herpesvirus saimiri-transformed lymphoid cell line.	the lymphoid cell line #1670 has been derived from the infiltrated spleen of a tumor-bearing marmoset monkey infected with herpesvirus saimiri. the cells contain both types of h. saimiri dna, unique light (l-) dna (36% cytosine plus guanine) and repetitive heavy (h-) dna (71% cytosine plus guanine), without producing infectious virus. viral dna was found to persist in these cells as nonintegrated circular dna molecules. closed circular superhelical viral dna molecules were isolated by three subs ...	1977	195090
experimental cytomegalovirus infection and the developing mouse inner ear: in vivo and in vitro studies.	mouse cytomegalovirus causes perilabyrinthitis in the cochlea following intracranial inoculation of the newborn mouse. in spite of infection of cranial nerve ganglion cells and schwann cells the organ of corti achieves normal adult morphology including efferent nerve endings. no involvement of neuroaxons is seen. in comparison human cytomegalovirus infection causes endolabyrinthitis without involving periotic connective tissues or nerves even in the presence of meningoencephalitis. the lack of e ...	1977	195137
spontaneous mutations in ageing human cells: studies using a herpesvirus probe.	several fundamental theories of ageing postulate that spontaneous mutations increase in somatic cells as they age. this has not until recently been directly tested in mammalian cells, because of the problem of estimating mutation rate in declining cell populations. one possible approach is to infect cells with lytic virus and measure the mutation frequency in virus made by the cellular machinery. three temperature-sensitive mutants of herpesvirus were used to infect human fibroblasts in vitro. t ...	1977	195146
purification of herpesvirus nucleocapsids by fluorocarbon extraction.	purified nucleocapsids were prepared from herpes simplex virus type-1 and herpes simplex virus type-2 infected cells, using a fluorocarbon extraction technique with freon 113. fifty to 85% of the total nucleocapsid population remained 'nucleated' or full in terms of the nucleic acid core making them useful as a source of dna. cscl banded dna represented 30--40% of the theoretical yield of the total nucleocapsid population.	1976	195183
ribonucleotide reductase activity in hydroxyurea-resistant herpesvirus replication.		1977	195286
in vitro stimulation of foal lymphocytes with equid herpesvirus 1.		1977	195321
electron microscopic study of herpesvirus saimiri.		1977	195393
equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease.	experimental infection with equine herpesvirus 1 (rhinopneumonitis) resulted in neurologic disease in 8 of 15 inoculated horses. nonpregnant animals did not develop clinical disease, and microscopic examination of tissues revealed no changes. in all mares between 3 and 9 months of gestation, a neurologic syndrome appeared 6 to 8 days after inoculation. mares inoculated when 10 months pregnant did not develop neurologic disorders, but several aborted. the histopathologic change common to both seq ...	1977	195494
clinical, serologic, and cross-challenge response and virus isolation in cattle infected with three bovine dermatotropic herpesviruses.	the relationship of 3 dermatotropic bovine herpes-viruses (bovine mamillitis herpesvirus, dermatotropic bovine herpesvirus, and allerton virus) was investigated; special emphasis was on the clinical response and the development of complement-fixation and precipitating antibodies in cattle. the immune respnse in steers was determined throughout the disease and after challenge exposure of the steers with 1 of the other 2 herpesviruses. blood samples and sections of skin were collected intermittent ...	1977	195495
influence of dibutyryl cyclic amp on thymidine uptake by herpes simplex virus infected cells and the intracellular level of cyclic amp.	dibutyryl cyclic amp inhibits the increase of dthd and brdurd transport normally observed after infection with herpesvirus hominis, type i and ii. incorporation is also reduced. inhibition of uptake is non-competitive as analysed by the lineweaver-burk plot. addition of this drug to infected cells also reduces the activity of the thymidine kinase (ec 2.7.1.75). transport of durd, dcyd and dado is not reduced. 4--8 h after infection with thymidine kinase (+) herpes strains the level of camp incre ...	1977	195614
virological studies of guinea pig leukemia: an overview with reference to herpesvirus and oncornavirus.		1977	195845
development of cell-mediated immunity to epstein-barr herpesvirus in infectious mononucleosis as shown by leukocyte migration inhibition.	eight patients with infectious mononucleosis, aged between 8 and 24, were studied for cell-mediated immunity by the in vitro leukocyte migration inhibition test at acute and convalescent stages. follow-up studies were also carried out at up to 4 months after clinical illness. cell-mediated immunity to epstein-barr virus (ebv) in the peripheral leukocytes from these patients was absent or incipient in all cases during the acute phase, although it was present in lymphocytes from a biopsied lymph n ...	1977	195902
rapid detection of human cytomegalovirus and herpesvirus hominis igm antibody by the immunoperoxidase technique.	immunoglobulin m (igm) to human cytomegalovirus (cmv) and herpesvirus hominis (hvh, types 1 and 2) has been searched for in a group of patients with congenital and recent cmv and hvh infections and also in a group of patients with remote cmv and recurrent hvh infections, using the immunoperoxidase antibody technique (ipa) as compared to a technique using sucrose density gradient differential centrifugation. both techniques detected the same positive samples. high igm antibody titers (1:32-1:512) ...	1977	195911
simple mathematical deductions in the seroepidemiology of viral infections. i. herpesvirus group (herpesvirus hominis, varicella-zoster virus, cytomegalovris, epstein-barr-virus).	large samples of nonselected persons collected in south-west germnay were investigated for the prevalence of serum antibodies to the human herpesviruses hsv, vzv, cmv and ebv. according to "catalytic models", which compare the infection spread to simple chemical reactions of molecules, a mathematical approximation of the serum surveys was performed. through a new deduction of the exponential function y = k (l - e-r+) a simple way was found to estimate the annual attack rates in percent of the su ...	1977	196453
herpesvirus infection of the respiratory tract electronmicroscopic observation of the virus in cells obtained from a sputum cytology.	a case of herpesvirus infection of the respiratory tract in which the virus was seen ultrastructurally in cells obtained from a routine sputum collected for cytology studies, is presented. the method described would seem feasible for additonal studies at the ultrastructural level of cells obtained during collection of material for routine cytology of the respiratory tract. in the present case the virus particles were easily seen and characterized.	1977	196463
eczema herpeticum caused by herpesvirus type 2. a case in a patient with darier disease.	this, to our knowledge, is the first documented report of eczema herpeticum due to infection with herpesvirus hominis type 2. the virus was isolated from a patient with known darier disease who developed kaposi varicelliform eruption. recent increases in the incidence of infection with type 2 herpes simplex as well as the high frequency of recurrence with this virus make this infection of potential significance in patients with preexisting cutaneous disease.	1977	196558
isolation and identification of marek's disease virus by fluorescent antibody technique.	cell-associated herpesvirus related to marek's disease (md) was isolated from the direct culture of kidney cells of naturally infected chickens at taoyuan or by inoculation of clinical specimens to chick kidney (ck) and chick embryo fibroblast cells. the virus isolates replicated in ck or chick embryo kidney cell cultures were identified to be md by the fluorescent-antibody technique.	1976	196818
in vitro studies on the mechanism of herpesvirus plaque growth inhibition by sensitized lymphocytes.	inhibition of herpesvirus plaque growth was observed when herpes simplex virus (hsv)-sensitized rabbit lymphocytes were placed in contact with an hsv-infected human foreskin monolayer. this inhibition was obtained as early as 3 h when a ratio of 6 viable lymphocytes to target cells was used, and the supernatants of these cultures also demonstrated plaque size reduction when put onto newly infected cell monolayers. interferon, which is present in this system, had no effect on hsv when tested on h ...	1977	197019
transformation of lymphocytes by herpesvirus papio.	cotton-topped (ct) or white-lipped (wl) marmoset lymphocytes were transformed in vitro with herpesvirus papio (hvp) into permanently growing lymphoblastoid cell lines (lcl). five of 9 hvp-transformed ct cell lines contained cells with antigens reacting with antibodies to epstein-barr virus (ebv) capsid antigen (vca) and/or to ebv-induced early antigens (ea). none of 12 wl lcl revealed such antigen-producing cells. cells from both groups of cultures failed to react with antibodies to the ebv-spec ...	1977	197025
techniques for typing herpesvirus hominis antibody: a comparison of inhibition of peroxidase-labelled antibody staining with inhibition of indirect haemagglutination and with microneutralisation.	a new technique based upon the inhibition of the peroxidase-labelled antibody staining (plas) has been used to type herpesvirus hominis (hvh) antibodies in four groups of human sera taken from patients with one or both types of hvh infection and in mixtures of different proportions of type 1 and type 2 antisera. the results were compared with those of the microneutralisation (mn) test and the indirect haemagglutination (iha) inhibition test. the sensitivity and specificity of the three methods w ...	1977	197239
histopathological observation of chicken inoculated with c-type virus isolated from the material infected with turkey herpesvirus.		1976	197292
relationships between reticuloendothelial virus of chickens and an agent isolated from a duck embryo cell culture of turkey herpesvirus.		1976	197293
ocular findings associated with encephalomyelitis caused by herpesvirus simiae.	a 29-year-old monkey handler developed acute encephalomyelitis with serological evidence of herpesvirus simiae infection. he had sudden unilateral loss of vision on the 32nd day of illness caused by vitreous hemorrhage. this cleared gradually, revealing chorioretinal scarring and a gliovascular vitreous band which eventually caused local tractional retinal detachment.	1977	197852
antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.	1-beta-d-arabinofuranosylthymine (ara-t), a metabolite of the sponge tethya crypta, has shown selective activity against herpes simplex virus (hsv) replication (g. a. gentry and j. f. aswell, virology 65:294-296, 1975). analysis of hsv-infected and uninfected cell lysates by cscl isopycnic centrifugation showed that ara-t blocked the incorporation of [(3)h]hypoxanthine into viral deoxyribonucleic acid and, to a large extent, into host deoxyribonucleic acid of infected (but not uninfected) cells. ...	1977	197886
the herpesvirus group.	several agents in the herpesvirus group are known to infect man. they cause a wide variety of conditions, ranging from coldsores to chickenpox and shingles. at the same time a number of the herpesviruses have been linked with malignant diseases in both lower animals and man.	1977	198052
epstein-barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.	when sensitized leukocytes were re-exposed to ebv antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited ebv-induced transformation and ebv superinfection of target cells. unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenge ...	1977	198380
prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts.	the prevalence, incidence, and source of infections with different types of herpesviruses were determined prospectively for 25 persons undergoing hemodialysis, 30 allograft recipients, and 16 kidney donors. the prevalence of prior infections with cytomegalovirus (cmv), herpes simplex virus (hsv), and epstein-barr virus (ebv) was high (72%-100%) and was similar for healthy persons and those with renal failure. the incidence of infections in patients undergoing hemodialysis was no greater than tha ...	1977	198488
[experience with herpesvirus infection transmitted through a finger tip].		1977	198498
susceptibility of common marmosets (callithrix jacchus) to oncogenic and attenuated strains of herpesvirus saimiri.	adult common marmosets, inoculated with either of 2 oncogenic herpesvirus saimiri (hvs) strains, developed fatal lymphoproliferative disease within 23-25 days post inoculation (pi). the disease was identical to hvs-induced lymphoma in cotton-topped and white-lipped marmosets. common marmosets inoculated with an attenuated hvs strain developed persistent infection; virus has been recovered from cocultivated lymphocytes of these animals for more than 384 days pi.	1977	198565
establishment of a cell line with associated epstein-barr-like virus from a leukemic orangutan.	an epstein-barr virus like herpesvirus has been isolated from a lymphoid cell line derived from an orangutan with spontaneous myelomonocytic leukemia. herpesvirus has not previously been isolated from this species of higher ape.	1977	198878
[study of viremia in chronic human herpetic infection].	attempts at virus isolation were made on the blood specimens from patients with relapsing herpesvirus infection. examinations of over 100 blood specimens from patients with various localizations of herpetic lesions yielded ii strains of herpesvirus. in all the cases the virus was isolated from a mixture of leukocytes with erythrocytes of the blood of patients. the method of cocultivation of blood leukocytes with cell cultures was most sensitive and yielded 7 herpesvirus isolates. the herpesvirus ...	1977	198957
[study of the antigenic properties of herpesvirus strains isolated from herpetic lesions at different sites].	the antigenic properties of 15 strains of hepesvirus isolated from herpetic lesions of different localization were studied. the serotype of each strain was established by the neutralization tests with hyperimmune sera to the reference type 1 and 2 strains: the cross-neutralization tests revealed antigenic relationships between the strains of 1 and 2 serotypes. most strains isolated from lesions of the genitalia belonged to type 2, although one strain isolated in herpes genitalis belonged to type ...	1977	198960
atypical herpesvirus hominis type 2 infection in uremic patients receiving immunosuppressive therapy.	in four uremic patients (three renal transplant recipients and one with idiopathic thrombocytopenia), painful, initially vesicular lesions developed in the anogenital region while they were receiving immunosuppressive drug therapy. these lesions enlarged, coalesced and ulcerated, presenting a puzzling diagnostic problem. initial misdiagnoses often resulted in inappropriate antimicrobial therapy. routine cultures, histologic sections and tzanck preparations were seldom helpful. the correct diagno ...	1977	199060
equine rhinopneumonitis virus (herpesvirus type 1): attenuation in stable monkey cell line.	an isolate of virulent equine herpesvirus (ehv) type 1 was adapted to vero stable cell line by 13 serial passages at 37 c and 50 serial passages at 26 c. characteristics of the attenuated ehv-1 were found to be avirulent, but immunogenic in horses if injected intramuscularly. the attenuated virus was regularly isolated from peripheral leukocytes in inoculated horses, but was not recovered from nasal turbinate tissues. a mild leukopenia was noticed. the attenuated virus produced characteristic la ...	1977	199093
a study of cytomegalovirus, epstein-barr virus and herpesvirus hominis (types 1 and 2) antibody in institutionalized and non-institutionalized children.	in an attempt to demonstrate differences in antibody prevalence between free-living and institutionalized children, antibodies to cytomegalovirus (cmv), epstein-barr virus (ebv), and herpesvirus hominis (hvh), types 1 and 2, were assayed in 123 children. the children comprised three groups consisting of 41 institutionalized patients with down's syndrome (all non-disjunctive trisomy-g karyotype and equal numbers of age-, sex-, and race-matched non-mongoloid institutionalized subjects and non-inst ...	1977	199558
herpetic whitlow as part of genital virus infection.	lesions on fingers or hands caused by herpesvirus hominis have in the past been attributed to inoculation with virus-containing oropharyngeal secretions. often these "herpetic whitlows" were caused by h. hominis type 1 and occurred in medical personnel. a recent series of 13 recurrent "herpetic whitlows" yielded 11 isolates of h. hominis type 2 and only two of h. hominis type 1. none of the subjects was engaged in patient care, and none had oral or facial herpetic lesions. nine of the 11 infecti ...	1977	199676
[attempts at specific immunoprophylaxis against herpes mammillitis].	a live cell culture adsorbate vaccine was produced against herpes mammillitis in cattle. comparative investigations were carried out on the immunogenic properties of four vaccines having different adjuvants--aluminum hydroxide, saponin, arlacell, and freund's adjuvant. all tested vaccines proved harmless and immunogenic for sensitive cattle, the highest immunogenic effect being produced by the vaccine that contained aluminum hydroxide and freund's adjuvant. the vaccinated animals reacted to immu ...	1977	199986
the prevalence of herpesvirus hominis in genital lesions with suggestive chancre morphology.		1977	200136
herpesvirus in sensory and autonomic ganglia after eye infection.	in herpesvirus hominis (hvh) infections, virus harbored in the sensory ganglia is now thought to be the main source of recurrent infection at peripheral sites. experimental hvh infection of the external eye in rabbits produces an acute infection and then latent infection of the trigeminal ganglion. in this study, acute infection of the automatic ganglia serving the eye (superior cervical and ciliary) as well as trigeminal ganglia occurred after hvh inoculation of rabbits' corneas with a herpes t ...	1977	200208
cell mediated immunity in equine herpesvirus type 1 infection i. in vitro lymphocyte blastogenesis and serum neutralization antibody in normal parturient and aborting mares.	blastic transformation of peripheral blood mononuclear cells and serum neutralization antibody levels for equine herpesivurs type 1 were measured in 19 mares from three farms at the time of termination of their pregnancy by normal foaling or viral abortion. the stimulation indexes of lymphocytes obtained from the mares from two farms (farm 1 and 2) which had virus abortions, ranged from 2.1 to 10.8. but there was no significant difference in stimulation index levels between the aborting and norm ...	1977	200317
effect of age and pregnancy on the antibody and cell-mediated immune responses of horses to equine herpesvirus 1.	the cell-mediated immune response and antibody response of horses of varying ages and of pregnant horses to equine herpesvirus 1 antigen were examined. six to eight month old horses showed either no increase or slight increases in anti-equine herpesvirus 1 serum neutralizing antibody following vaccination and revaccination with a modified live equine herpesvirus 1 vaccine. however, these same horses showed a marked increase in the cell-mediated immune response to equine herpesvirus 1 as measured ...	1977	200320
isolation of infectious eb virus from the epithelial tumour cells of nasopharyngeal carcinoma.	evidence of herpesvirus replication has been found by light and electron microscopy in the malignant epithelial cells of two out of six nasopharyngeal carcinomas (npc) examined directly after growth in nude mice to eliminate non-malignant infiltrating cells. the agent has been identified as eb virus by immunofluorescence tests for eb virus capsid antigen, and has been shown to be biologically active by its ability to infect and transform foetal cord blood lymphocytes. lymphoblastoid cell lines w ...	1977	200568
herpesvirus-like infection in two pacific pond turtles.		1977	200595
characterization of herpesviruses isolated from lactating dairy cows with mammary pustular dermatitis.	herpesviruses serologically indistinguishable from the dn599 strain of bovine herpesvirus were isolated from 2 separate enzootics of mammary pustular dermatitis in lactating holstein-friesian cows.	1977	201190
herpesvirus-induced urolithiasis in specific-pathogen-free male cats.		1977	201200
isolation of marek's disease herpesvirus of low pathogenicity from commercial chickens.		1977	201237
enhancement of antibody-dependent cell-mediated cytotoxicity of herpesvirus-infected cells by complement.	an investigation was made of the effects of complement on the levels of antibody-dependence cytotoxicity (adcc) mediated by bovine leukocytes against herpesvirus-infected target cells. neutrophil-mediated adcc was considerably enhanced upon the addition of low levels of complement that alone failed to induce lysis of antibody-sensitized target cells. this enhancement was most apparent under suboptimum conditions such as at low effector-to-target cell ratios, low levels of sensitizing antiserum, ...	1977	201564
infectious bovine rhinotracheitis: a review and update.	infectious bovine rhinotracheitis (ibr), a herpesvirus infection of cattle, has diverse clinical manifestations. known mainly as a respiratory tract disease characterized by tracheitis, rhinitis, and fever, ibr plays a prominent role among causes of undifferentiated bovine respiratory disease and abortion. it also causes conjunctivitis, infectious pustular vulvovaginitis, balanoposthitis, and rarely, encephalitis. the virus is readily transmitted and has worldwide distribution. some cattle devel ...	1977	201597
anti-complement immunofluorescence test for antibodies to human cytomegalovirus.	an anti-complement immunofluorescence (acif) test that detects human cytomegalovirus (cmv) antigen in the nuclei of infected cells was used for assay of cmv antibodies in human sera. various factors influencing the sensitivity and specificity of the acif test system were investigated, and results were applied to the development of a procedure which could be completed in a relatively short length of time and gave reproducible results. results obtained in the acif test were compared with those obt ...	1977	201664
attempts to immunize monkeys against experimental infection with herpesvirus suis.		1977	201677
genetic relatedness of equine herpesvirus types 1 and 3.	the genetic relatedness of two types of equine herpesviruses (ehvs), 1 (ehv-1) and 3 (ehv-3), was determined by dna-dna reassociation kinetics. denatured, labeled viral dna probe was allowed to reassociate in the presence or absence of the second unlabeled viral dna. the initial rate of reassociation of either labeled viral dna was increased by the presence of the heterologous viral dna to an extent indicating only 2 to 5% homology between the two ehv genomes. moreover, labeled rna extracted fro ...	1977	201775
replication of type i herpes simplex virus in primary cultures of hairy cell leukemic leukocytes.	the ability of leukemic leukocytes to support the replication of herpes simplex virus (hsv) was studied. mononuclear leukocytes (mnl) from the peripheral blood of patients with a variety of lymphoid leukemias were isolated on ficoll-hypaque gradients and infected with hsv at a multiplicity of infection of 5 to 10. no virus growth was detected in cells from patients with chronic lymphocytic leukemia (9), acute lymphocytic leukemia (1), or lymphosarcoma cell leukemia (2), hsv replication did occur ...	1978	202167
herpesvirus ateles dna and its homology with herpesvirus saimiri nucleic acid.	analysis of the structural organization of herpesvirus ateles dna shows that two types of viral dna molecules are encapsidated in virions: (i) m-genomes, which contain 74% light sequences (l-dna, 38% guanine plus cytosine) and 26% highly repetitive heavy sequences (h-dna, 75% guanine plus cytosine), and (ii) defective h-genomes, which consist exclusively of repetitive h-dna. the structure of m-genomes from h. ateles consists of an l-dna region of about 70 x 10(6) daltons inserted between h-dna t ...	1978	202747
[chromosomes of 7 transplantable lines of macaque and pavian hematopoietic cells producing herpesvirus type ebv and oncornavirus type c].	karyotypes of su-1, su-2, kmma-1, and kmma-2 (producing oncornavirus c-type), and kmpg-1, spf-2, and spg-3 (producing hsv, a virus of ebv type) cell lines were studied in the time course. the lines were derived from hemopoietic cells of brown macaques and baboons bearing lymphomas. some of the lines had a paradiploid-pseudodiploid karyotype, another part aneuploid type. the selectivity of structural and numerical abnormalities of chromosomes 1, 9, 10, 11, 12, 13, 15, 18, and 20 was detected indi ...	1977	203114
[in vitro studies of the antiviral activity of ammonium humate against herpes simplex virus type 1 and type 2 (author's transl)].	ammonium humate, isolated from peat water, is a higher molecular polyphenolic compound with a strong antiviral activity against herpes simplex virus type 1 and type 2. three cell lines were chosen for examining the cytotoxicity of ammonium humate: rabbit kidney primary cells, hep-2- and fl-cells. as the light microscopic examination of both, the monolayers and the stained cover-glass cultures, revealed, concentrations of up to 5 microgram/ml ammonium humate can be used without hesitation for rab ...	1977	203143
[severe ocular manifestations attributed to a type 2 herpesvirus].		1977	203898