Publications

molecular biology of oncogenic inflammatory processes. i. non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens, and microrna/dna interactions (review).	in some inflammasomes tumor cells are generated. the internal environment of the inflammasome is conducive to the induction of malignant transformation. epigenetic changes initiate this process. the subverted stromal connective tissue cells act to promote and sustain the process of malignant trans-formation. in its early stages, the premalignant cells depend on paracrine circuitries for the reception of growth factors. the ligands are d ...	2012	22076306
The pathology of 'scale drop syndrome' in Asian seabass, Lates calcarifer Bloch, a first description.	This is the first pathological description of 'scale drop syndrome' (SDS) in Asian seabass, Lates calcarifer Bloch. Cumulative mortality was estimated at 40-50%. The vasculitis in all major organs including the skin and associated tissue necrosis was distinctive. The dermis overlying scale beds was often necrotic and associated with scale loss. Necrosis of splenic ellipsoids, renal glomeruli and choroid rete glands of eye were further hallmarks of a disease with systemic vascular involvement. Th ...	2012	22103767
kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors.	hypoxia and hypoxia-inducible factors (hifs) play an important role in the kaposi's sarcoma-associated herpesvirus (kshv) life cycle. in particular, hypoxia can activate lytic replication of kshv and specific lytic genes, including the replication and transcription activator (rta), while kshv infection in turn can increase the levels and activity of hifs. in the present study, we show that hypoxia increases the levels of mrnas encoding kshv latency-associated nuclear antigen (lana) in primary ef ...	2012	22090111
novel virus-encoded microrna molecules expressed by ovine herpesvirus 2-immortalized bovine t-cells.	a number of herpesviruses have now been shown to encode micrornas (mirnas) that have roles in control of both viral and cellular gene expression. ovine herpesvirus 2 (ovhv-2) is the causative agent of sheep-associated malignant catarrhal fever, a fatal lymphoproliferative disease of cattle. using massively parallel sequencing and northern hybridization we have identified eight putative mirnas encoded by ovhv-2 expressed in an ovhv-2-immortalized bovine lymphocyte cell line. these eight mirnas ar ...	2012	21957125
Bacterial artificial chromosome clones of viruses comprising the towne cytomegalovirus vaccine.	Bacterial artificial chromosome (BAC) clones have proven invaluable for genetic manipulation of herpesvirus genomes. BAC cloning can also be useful for capturing representative genomes that comprise a viral stock or mixture. The Towne live attenuated cytomegalovirus vaccine was developed in the 1970s by serial passage in cultured fibroblasts. Although its safety, immunogenicity, and efficacy have been evaluated in nearly a thousand human subjects, the vaccine itself has been little studied. Inst ...	2012	22187535
Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent tunisian patients with acute neuromeningeal disorder.	Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourgu ...	2012	22170549