Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| defense mechanisms against bovine herpesvirus: relationship of virus-host cell events to susceptibility to antibody-complement cell lysis. | the interaction of infectious bovine rhinotracheitis virus and susceptible host cells was examined to determine whether an infected cell could be destroyed by humoral immune mechanisms before or after the transmission of virus to susceptible adjacent cells. viral antigens were detectable on cell membranes at 6 h postinfection, but cells were not susceptible to antibody-complement lysis until 10 h postinfection. intracellular infectious virus was also detectable at 10 h postinfection, and transmi ... | 1975 | 53206 |
| characterization of a new serotype of marek's disease herpesvirus. | the hprs-24 strain of marek's disease herpesvirus was selected for closer study from a group of virus isolates that appeared apathogenic under standard test conditons. protection studies revealed an immunological relationship between this virus strain and acute marek's disease herpesvirus. in chicken kidney cell cultures, the hprs-24 strain caused small and slowly developing plaques, and the proportion of infected cells was less than with other strains. in chicken embryo fibroblast cultures, thi ... | 1975 | 66180 |
| t-lymphoblastoid cell lines from marek's disease lymphomas. | the establishment and continuous culture of two lymphoblastoid cell lines derived from marek's disease lymphomas is described. although the cells carried t-lymphocyte surface antigens, they had many features in common with cultured burkitt's lymphoma lymphoblasts, which carry b-cell determinants. a small proportion acted as infectious units in tissue culture, and a similarly small proportion contained intranuclear immature herpesvirus particles. the cells did not respond to phytohaemagglutinin. ... | 1975 | 66182 |
| virus infections in renal transplant recipients. | 534 serum samples from 73 renal transplant recipients, 41 haemodialysis patients, and 99 blood and organ donors were examined serologically for antibodies against cytomegalo, h. simplex (types 1 and 2), varicella-zoster, epstein-barr, adeno, influenza, parainfluenza, respiratory syncytial, measles, picorna- and human polyoma- viruses. serum specimens were stored in the lyophilized state until examined thus enabling a simultaneous testing of all samples belonging to one patient. all antigens, com ... | 1975 | 126545 |
| coital exanthema in stallions. | equine coital exanthema can be produced experimentally in stallions by inoculation with an equine herpesvirus (strain 65/61) and be transmitted during coitus with an infected mare. serological responses to this infection include the production of complement-fixing and serum-neutralizing antibodies which reach maximum levels 14 to 21 days after infection. complement-fixing antibodies decline rapidly and are usually not detectable by 60 days after infection, whereas serum-neutralizing antibody act ... | 1975 | 173847 |
| experimental studies on equine herpesvirus type 1 infections. | the ehv-1 viruses of fetal origin grew better and had a wider tissue culture host range than those isolated from horses with respiratory diseases. comparisons of a fetal isolate (f/304) and a respiratory disease isolate (r/nm-3) in partly immune horses showed that the f/304 virus infected horses more readily, grew better in the nasopharynx, was more likely to cause abortion, and was excreted to a greater extent into the environment. | 1975 | 173849 |
| attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees c. | a variant of herpesvirus saimiri (hvs) stably attenuated for marmosets was isolated after serial passage of wild-type hvs in cell culture at 39 degrees c. marmosets previously inoculated with attenuated virus experienced a significant delay in the development of lymphoma when challenged with wild-type hvs. | 1975 | 173864 |
| in vitro evaluation of cell-mediated immunity to epstein-barr herpesvirus by cell migration inhibition tests. | migration of peripheral leukocytes in samples from sensitized [epstein-barr virus (ebv) antibody-positive] humans was greatly inhibited when challenged by antigen prepared from ebv-producing p3hr-1 cells but not by antigen prepared from ebv-nonproducing raji cells, ebv-negative human fibroblasts, or epithelial cells. such inhibition was not observed when peripheral leuocytes from subjects or neonates not sensitized to ebv were challenged. similar results were obtained in a two-stage test when th ... | 1975 | 173867 |
| herpesvirus hominis infection in pregnancy. | 1975 | 174127 | |
| the pathogenesis of simian varicella virus in cynomolgus monkeys. | the mlm herpesvirus is infectious for cynomolgus monkeys. the disease in this species, possibly modulated by preinoculation antibody resembles human varicella. virus has been recovered from blood during the early incubation period, and from liver, lymph nodes, kidney, bladder and urine during the eruptive period of infection. the major target organs were skin and liver; specific pathological changes developed in both. appropriate antibody responses, including those to herpesvirus varicellae foll ... | 1975 | 174129 |
| enhancement and interference in chickens inoculated with marek's disease herpesvirus and oncornaviruses. | enhancement of mortality rates and symptomatology was observed in isolator-held lsi-spf chickens concurrently inoculated with mdhv and avian oncornaviruses (rav-1, rav-2, rav-7, rav-50, or rev). interference with md antigen production also was demonstrated in extracts of the feather follicle epithelium from chickens inoculated with both mdhv and rav-1. | 1975 | 174137 |
| genital infection of female hamsters with herpesvirus hominis type 2 (hvh-2). | intravaginal inoculation of female hamsters (40-65 g) with hvh-2 (6 x 105 pfu) results in an infection of 40-67% of the animals. the illness is characterized by vaginitis with discharge, paralysis, and finally death. washing the vagina with saline 30 min prior to virus inoculation enhances the infection so that 80-100% of the animals eventually die. virus can be isolated from the vagina within 1-2 days after inoculation. evidence of infection of the spinal cord is apparent by the third day where ... | 1975 | 174142 |
| prospects for herpesvirus vaccination--safety and efficacy considerations. | 1975 | 174154 | |
| an avian-related new herpesvirus infection in man--subacute myelo-optico-neuropathy (smon). | 1975 | 174155 | |
| [porperties of a strain of herpesvirus suis isolated in cases with various epizootologic and clinical courses of the disease]. | a varying epizootologic, clinical and morphologic picture was established in studying the course of the disease on six pig-breeding farms. the isolated strains showed differences in their virulence, cultural properties and physicochemical behaviour. two of them had lowered virulence, and one showed affinity to the respiratory organs which corresponded to the peculiarities and course of the disease. it is concluded that the interaction between the virulence of the strains and the herd immunity re ... | 1975 | 174278 |
| purification of herpesvirus saimiri and properties of the viral dna. | conditions for growth, concentration, and purification of herpesvirus saimiri were determined. optimal yields of infectious herpesvirus saimiri (hvs) were obtained from infected owl monkey kidney (omk) cells grown at 32.5 degrees c in medium containing 10 per cent fetal calf serum. forth-five percent of the initial infectious hvs was recovered after an 18-fold concentration using 8 per cent polyethylene glycol 6000 in the presence of 0.5 m nacl. polyethylene glycol concentrated hvs was purified ... | 1975 | 174525 |
| evidence of respiratory tract infection induced by equine herpesvirus, type 2, in the horse. | five horses were experimentally exposed to equine herpesvirus 2 strain lk. two young foals developed chronic pharyngitis (98 and 232 days, respectively). growth characteristics, cytopathic effects (cpe), inclusion body formation, ether sensitivity, and immunofluorescent analysis indicated that the virus recovered from infected animals was a herpesvirus serologically identical with, or at least antigenically related to ehv-2 strain lk. no significant complement-fixing (cf) or virus-neutralizing ( ... | 1975 | 175904 |
| chemotherapy of herpesvirus infections. | herpesviruses commonly produce lesions that come to the attention of physicians. many different chemicals are known to suppress the growth of herpesviruses in vitro, but only a few of these have found application in clinical practice. a critical assessment of the place of some of these forms of chemotherapy was briefly presented. | 1975 | 175987 |
| letter: the isolation of a herpesvirus from pigeon and experimental infection in psittacine birds. | 1975 | 176985 | |
| evidence for suppressor cell activity associated with induction of herpesvirus saimiri-induced lymphoma. | peripheral blood lymphocytes (pbl) from herpesvirus saimiri (hvs) infected owl monkeys lose their ability to respond to pha during the development of lymphoma. in this study, five hvs-infected owl monkeys were examined for their ability to respond to pha and to confer this loss of pha reactivity to normal lymphocytes. four of the monkeys developed hvs-induced disease and lost their ability to respond to pha. although less affected, reduced responses were also found with pwm. the animals which de ... | 1975 | 178474 |
| [the photodynamic effect in herpes simplex: a review]. | photodynamic action is an extraordinarily potent physicochemical process which is dramatically lethal for herpesvirus and other organisms in vitro. recent studies in animal models and man indicate that the process is effective against in vivo skin infections as well. although a great deal is yet to be learned about the application of photodynamic action to clinical disease, current experience indicates that photodynamic action will find a permanent place in the physician's therapeutic armamentar ... | 1975 | 175035 |
| [electrophoretic profile of thermostable and thermoresistant herpesvirus proteins]. | 1975 | 179479 | |
| [study of the serum neutralization kinetics of some strains of bovid herpesvirus 2]. | 1975 | 179480 | |
| efficacy of turkey herpesvirus vaccine when administered simultaneously with fowl pox vaccine. | the efficacy of the turkey herpesvirus (hvt) vaccine in protecting chickens challenged with virulent marek's disease (md) virus was unaffected by the presence of either the chick embryo fowl pox vaccine or fowl pox vaccine derived from cell culture. conversely the hvt vaccine did not affect the efficacy of the fowl pox vaccine in chickens challenged with pathogenic fowl pox virus. a combination of spectinomycin dihydrochloride pentahydrate and lincomycin hydrochloride monohydrate as well as spec ... | 1975 | 180502 |
| presence of herpesvirus-associated antigens on the surfaces of transformed, tumor, and metastatic cells and enhanced antigenicity of transformed cells using 5-iodo-2'-deoxyuridine. | using a direct immunofluorescence technique, herpes simplex virus type 1 (hsv-1)-transformed cells and cell lines subsequently derived from tumors and metastases were examined for the presence of hsv-1-associated surface antigens. fluorescein-labeled immunoglobulins derived from antisera were used and included anti-hsv-1 (from hamsters), sera from tumor-bearing hamsters, and antibodies prepared in rabbits against cell material shed early into the medium after infection of rabbit kidney cells wit ... | 1975 | 179965 |
| ethio-pathogenetic therapy of herpesvirus eye infection. | 1975 | 181105 | |
| the role of herpesvirus saimiri genomes in oncogenic transformation of primate cells. | 1975 | 183689 | |
| correspondence between t cell suppression and adlc titers during herpesvirus saimiri (hvs) infection in owl monkeys. | 1975 | 183696 | |
| lymphocyte responsiveness in squirrel, cebus and marmoset monkeys infected with herpesvirus saimiri. | 1975 | 183704 | |
| antilymphocytic factor derived from a herpesvirus saimiri lymphoid tumor cell line. | 1975 | 183705 | |
| reactivation of squirrel monkey heart isolate (herpesvirus saimiri strain) from latently infected human cell cultures and induction of malignant lymphoma in marmoset monkeys. | 1975 | 183706 | |
| induction of angioid sarcoma and fibrosarcoma by a guinea pig herpesvirus-transformed hamster cell line. | 1975 | 183707 | |
| regulation of herpesvirus gene expression in biochemical transformed cells: investigations of virus-specified regulatory functions. | 1975 | 183722 | |
| cause of "nakanuke" in chickens. i. occurrence of "nakanuke" in chicken inoculated with the cells showed coexistence or c-type virus and turkey herpesvirus. | 1975 | 183038 | |
| cause of "nakanuke" in chickens. ii. isolation of c-type virus from material infected with turkey herpesvirus. | 1975 | 183039 | |
| persistence of herpesvirus nucleic acid in normal and transformed human cells - a review. | 1975 | 190112 | |
| structure and function of herpesvirus saimira dna. | two types of genomes are present in hvs stocks: (1) the defective h-genome consisting of highly reiterated heavy (71% c+g) sequences; and (2) the m-genome, which carries the whole genetic information of hvs and is infectious in tissue culture. the sequences in the m-genome are made up of 70% unique l-dna (with 36% c + g) and 30% h-dna, which is highly repetitive. h-sequences in the m-genome are clustered at the ends of the molecule. | 1975 | 190116 |
| studies of the dna of herpesvirus saimiri. | 1975 | 190117 | |
| partial purification and biochemical characterization of herpesvirus saimiri. | hvs propagated in vero cells was labelled with 3h-leucine and purified by isopycnic flotation in sucrose. electron microscopic examination revealed both complete and incomplete hvs. no significant contamination with cellular debris was noted. polyacrylamide gel electrophoresis analysis of solubilized virus revealed at least 12 proteins varying in molecular weight from 8 000 to 200 000 daltons. | 1975 | 190128 |
| altered fucolipid patterns in cells transformed by herpesvirus type 2. | 1975 | 190140 | |
| rna synthesis in cells infected with herpes simplex virus: analysis of high molecular weight and symmetrical viral transcripts in herpesvirus infected cells. | 1975 | 190144 | |
| some biological properties of herpesvirus saimiri from chronically infected monolayer and suspension cultures. | hvs-mest cells, which are adherent, produced more infectious hvs at 37 degress c than at 33 degrees c. this was paralleled by the appearance of ea and la in rounded cells and cf antigen in the cell cultures. in contrast, mlc-1 cells, which grow in suspension, produced hardly any infectious virus, but did produce more hvs s antigen than did the hvs-mest cells. production of s antigen in mlc-1 cells was augmented by treatment of the cells with budr. hvs-mest cells could be superinfected with hvs, ... | 1975 | 190156 |
| properties of the dna polymerase induced by marek's disease herpesvirus, strain ga, upon infection of duck embryo fibroblasts. | 1975 | 190161 | |
| [epidemiology in the study of the role of viruses in human cancers]. | an epidemiological approach is very useful in the study of the role of viruses in the development of human tumors, if properly integrated with the experimental approach and laboratory studies. certain epidemiological characteristics of human tumours favour a viral etiology, e.g. space and time clustering, vertical and horizontal transmission of a tumour risk, succession in space or in time of viral induced benign lesions and of malignant tumours. in the framework of the association between the e ... | 1975 | 175869 |
| herpesvirus infections in renal allograft recipients. | 17 of 37 immunosuppressed renal allograft recipients developed clinical and/or serological evidence of herpes simplex virus infections, 7 of 83 developed a zoster rash, 85 of loo had evidence of cytomegalovirus infection and in 3 of 30 an active epstein-barr virus was seen. | 1975 | 181840 |
| ultrastructural and immunofluorescent studies of the replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys. | the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and of three control owl monkeys were studied by electron microscopic (em) and immunofluorescent (if) techniques. buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, two of the five infected monkeys were leukaemic; within 50 days after the study, four of the five had died with malignant lymphoma and lymphocytic leukaemia. hvs virions were demonstrated by em and hv ... | 1975 | 191352 |
| immunological aspects of herpesvirus infections in primates. | 1975 | 191354 | |
| induction of herpesvirus saimiri lymphoma in new zealand white rabbits inoculated intravenously. | 1975 | 191364 | |
| analysis and description of procedures used in the study of the relationship of herpes simplex virus "non-virion" antigens to certain cancers. | after a brief review of the relationship of herpes simplex viruses to certain human cancers, a description is given of procedures used in the study of herpesvirus "non-virion" antigens, and various points on which disagreement currently exists are discussed. complement-fixation tests on these markers with both cancer and control sera as well as with "non-virion" antisera, which did not react with non-anti-complementary stored virion antigens, are described, and it is suggested that another param ... | 1975 | 191373 |
| studies of the nature of herpesvirus-induced tumour-associated antigens induced by herpes simplex virus type 1 and further analysis of their relationship with squamous-cell carcinomas of the head and neck region. | the differences seen in levels of antibody response to hsv-taa between non-laryngeal and laryngeal cancers in cured and untreated patient populations were due to the use of filtered sera. in previous and present studies using unfiltered sera, these differences were not noted. of unfiltered sera from patients with squamous-cell carcinomas of the head and neck, 89% (49 out of 55) were positive for cf reactivity to hsv-taa, and 44% of these unfiltered sera had titres of 1:4 or greater to 44 microng ... | 1975 | 191376 |
| induction of serum antibodies in non-human primates with a killed oncogenic herpesvirus (herpesvirus saimiri). | 1975 | 191378 | |
| in vitro attenuation of herpesvirus saimiri by serial passage in dog fetal lung continuous cultures. | 1975 | 191379 | |
| herpesvirus type 2-induced tumour-specific antigen (ag-4) and specific antibody in patients with cervical cancer and controls. | 1975 | 191387 | |
| [herpes virus isolated from pigeons (author's transl)]. | a virus has been isolated from pigeons with the clinical symptoms of "infectious coryza". the virus produces numerous pocks on the chorio-allantoic membranes; livers from infected embryos have areas of necrosis. microscopic examinations reveals basophilic and eosinophilic intranuclear inclusions. the virus produces a cytopathic effect of rounded refractile cells after 24 h with rapidly spreads throughout the monolayer. the virus is sensitive to chloroform. electron microscopy of negatively stain ... | 1975 | 182059 |
| antibodies to herpes simplex virus types 1 and 2: a comparative study using indirect haemagglutination in carcinoma of the cervix and in other malignant conditions. | the authors used a technique of indirect haemagglutination to compare levels of antibody to herpesvirus simplex types 1 and 2 in groups of patients with carcinoma of the cervix, together with other malignant conditions and in comparison to controls. a significant difference in the mean titre of antibody to type 2 virus is revealed between the carcinoma group and the b controls. the significance of the antibody assays is assessed by a study of the specificity of the antibodies found and by an ass ... | 1975 | 182291 |
| epidemiology and aetiology of cancer of the uterine cervix including the detection of carcinogenic n-nitrosamines in the human vaginal vault. | cancer of the uterine cervix occurs with high frequency in black females of several populations of southern africa. it accounts for 40-50% of all cancers in black females in the johannesburg area and for over 40% of those in women in the rural lowveld area of the transvaal. the aetiology of this cancer has several distinct features, almost all of which concern some or other aspect of coitus. age at first coitus and at first marriage, and promiscuity, are very strongly associated with the develop ... | 1975 | 1080296 |
| infection of human and rhesus lymphoblastoid cells with herpesvirus macaca. | the interaction between herpesvirus macaca and lymphoblastoid cells grown in continuous culture, or purified from rhesus blood, was studied as a model for latent or chronic herpesvirus infection of leukocytes. continuous lymphoblastoid cell lines infected in vitro were pa3, a human cell line with bone-marrow derived (b)-lymphocyte characteristics; lm/dm, a rhesus cell line with b-lymphocyte characteristics; and molt-4, a human cell line with thymus-derived (t)-lymphocyte characteristics. a disti ... | 1975 | 1082329 |
| virologic and serologic studies of zoo birds for marek's disease virus infection. | one hundred and eleven zoo birds representing 49 species in 14 orders were examined for marek's disease (md) herpesvirus (mdhv) infection. mdhv was isolated from 10 birds, all belonging to genus gallus. the precipitating antibodies against mdhv were demonstrated only in the gallus birds, when 51 selected birds including 34 galliformes and 17 other birds representing 12 species from nine orders were examined. the 10 mdhv isolates all induced morphologically similar plaques in cell cultures closel ... | 1975 | 1091554 |
| antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in ibadan, nigeria. | carcinoma of the cervix is by far the commonest gynecologic malignancy seen in ibadan, nigeria. in a study aimed at investigating the role of herpesvirus type 2 (ht-2) in its pathogenesis, antibodies to ht-2 were detected by immunofluorescence above a titer of 640 in 31 (70.5 percent) of 44 women with invasive carcinoma of the cervix as compared with five (11.1 percent) of 45 healthy women of the same age group. analysis according to histologic types of growths showed that 31 (83.8 percent) of 3 ... | 1975 | 1106197 |
| effect of povidone-iodine on herpes genitalis. | ten patients with vulvovaginal and cervical herpesvirus infections were treated with a regimen of external and intravaginal povidone-iodine preparations. in all but 1 case, the expected duration of symptoms and healing time were shortened. the response of cervical lesions was especially remarkable. the findings of this pilot study warrant further controlled clinical investigation. | 1975 | 1113955 |
| viremic responses of genetically susceptible and resistant chickens to experimental infection with acute, mild, or both strains of marek's disease herpesvirus. | the development and persistence of viremia were followed in two lines of single-comb white leghorns: one experimental line (wsu-vs) highly susceptible, and one commercial line (c-wl) relatively resistant to marek's disease(md). in the resistant c-wl chicken, viremia with a mild strain of md herpesvirus (mdhv) persisted in all viremic birds through 8 weeks postinoculation (pi), while viremia with an acute strain of mdhv did not, resulting in a decrease in number of viremic birds after 2 weeks pi. ... | 1975 | 1120039 |
| neutralising antibody to herpesviruses dervied from wildebeest and hartebeest in wild animals in east africa. | the sera of 728 game animals, collected in east africa, were tested for neutralising antibody to a strain (wc11) of wildebeest herpesvirus, which is an important cause of malignant catarrhal fever of cattle. in addition, 290 of these sera were tested for neutralising activity against a closely related herpesvirus (k/30) from hartebeest (alcelaphus sp.). antibody was frequently present in three species of the subfamily alcelaphinae (wildebest, hartebeest and topi) and one of the subfamily hippotr ... | 1975 | 1144919 |
| herpesvirus hominis infection in newborn mice: comparison of the therapeutic efficacy of 1-beta-d-arabinofuranosylcytosine and 9-beta-d-arabinofuranosyladenine. | intranasal inoculation of newborn mice with herpesvirus hominis type 2 provides an experimental infection that closely resembles disseminated herpesvirus infection of human newborn infants. after inoculation of mice, the virus multiplies in the respiratory tract and is disseminated through the blood to the liver and spleen and to the brain by both a viremia and nerve route transmission. although therapy with 1-beta-d-arabinofuranosylcytosine (ara-c) did not reduce final mortality, it did increas ... | 1975 | 1147590 |
| recovery of a new herpesvirus from the ground squirrel (citellus citellus). | a new herpesvirus recovered from the kidneys of mature ground squirrels (citellus citellus) produced an effect in tissue culture cells resembling that of herpesviruses, including the formation of multinucleated syncytia and type a intranuclear inclusions. the isolate caused latent infection in the natural host, but it proved fatal for intracerebrally inoculated suckling mice and it produced pocks on the chorioallantoic membrane of embryonated eggs. electron-microscopic examination of infected ce ... | 1975 | 1153219 |
| viral carcinogenesis in a pronephric cell line. an ultrastructural study. | herpesvirus recovered from cell fractions of the spontaneous lucké renal tumor of adult rana pipiens were used to infect a cell line derived from pronephroi of the same species. viruses and virus-associated structures previously found in the primary renal tumor were observed, including nuclear inclusions of capsids with single or double membranes and capsids with nucleoids often within nuclear sacs. embedded within the clumped and marginated chromatin were 55-nm tubular elements and associated u ... | 1975 | 1155580 |
| herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid. | intranasal inoculation of newborn mice with herpesvirus hominis (hvh) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(i:c)] significantly increased the mean survival time and markedly altered the pathogenesis of the infection. no significant protection against final mortality was observed. poly(i:c) therapy completely inhibited detectable viral replication in all target o ... | 1975 | 1155920 |
| the ultrastructure of lymphoblastoid cell lines from marek's disease lymphomata. | the ultrastructure of two lymphoblastoid cell lines derived from marek's disease lymphomata has been studied. the cells varied from 5 to 12 mum in diameter and had large round or oval nuclei. a nucleolus was occasionally present and about 3% of cells showed projections of the nuclear envelope. the cytoplasm contained many ribosomes and several mitochondria but endoplasmic reticulum was sparse. a small number of cells contained annulate lamellae and crystalline structures were occasionally seen. ... | 1975 | 1156510 |
| effects of strain of chickens and vaccination with turkey herpesvirus on marek's disease and lymphoid leukosis in breeding stocks. | 1. a total of 3236 females from eight meat-type strains, half of which were vaccinated for marek's disease (md), and 11,193 leghorn females from ten strains, all vaccinated for md, were adventitiously exposed to md and lymphoid leukosis (ll) viruses and observed to 392 and 497 d of age, respectively. 2. in the meat-type birds, vaccination reduced total mortality from 43-4% to 27-1% and mortality due to md from 16-4% to 5-4% but did not affect mortality and ll (2-9% and 3-4%). 3. in the vaccinate ... | 1975 | 1156921 |
| a comparison of the efficacy against marek's disease of cell-free and cell-associated turkey herpesvirus vaccine. | one-day-old white leghorn and broiler chicks with maternal antibody to turkey herpesvirus (hvt) were vaccinated with 300 or 1,000 plaque-forming units (pfu) of cell-free or cell-associated hvt vaccine and challenged with virulent marek's disease virus (mdv) by contact exposure. broiler chicks receiving 300 pfu of cell-associated hvt had a 3.3% incidence of md lesions, whereas only 2.0% of those receiving 1,000 pfu had macroscopic lesions. broiler chicks vaccinated with 300 pfu of cell-free vacci ... | 1975 | 1164319 |
| immunisation of cattle against the herpesvirus of malignant catarrhal fever: failure of inactivated culture vaccines with adjuvant. | attempts were made to immunise cattle against the herpesvirus of malignant catarrhal fever by inoculating living or formalinised preparations of the agent, propagated in cell cultures and combined with freund's incomplete adjuvant. high and persistent levels of virus-neutralising antibody were regularly demonstrable, especially following two intramuscular inoculations at an interval of six to eight weeks. in spite of this no protection was demonstrable against parenteral challenge with virulent ... | 1975 | 1166120 |
| characterization of three species of nucleocapsids of equine herpesvirus type-1 (ehv-1). | 1975 | 1167720 | |
| immunoferritin and immune electron microscopic study of bovine herpesvirus strain dn-599. | intracellular antigens of strain dn-599 bovine herpesvirus were detected in the cytoplasm and the nucleus of infected bovine embryonic kidney cells by the indirect immunoferritin (if) technique. specific tagging was observed in viral envelope and capsids. aggregates of viral particles heavily coated with antibody were seen by immune electron microscopy (iem). | 1975 | 1167771 |
| neonatal risk following late gestational genital herpesvirus hominis infection. | five women developed genital herpesvirus hominis (herpes simplex virus) infection beyond 32 week's gestation. two of the women had fresh vesicular lesions at parturition. the five infants were delivered per vaginum at term and escaped subsequent overt herpesvirus hominis infection, although a scalp lesion in one infant was dismissed as inconsequential and disappeared without virologic study. examination of the infants two months to four years after birth failed to detect sequelae of possible sub ... | 1975 | 1168410 |
| tubular structures in rabbit kidney cells infected with herpesvirus cuniculi. | 1975 | 1180871 | |
| [some scientists of upjohn use experimental animals to study herpesvirus type 2]. | 1975 | 1187007 | |
| isolation and characterization of a herpesvirus from wild turkeys (meleagris gallopavo osceola) in florida. | viral agents producing both a syncytial-type cytopathic effect and type a intranuclear inclusion bodies in vitro were isolated from the kidneys of five of 10 wild turkeys. a plaque assay system for viral infectivity was developed and used to characterize one of the wild turkey viruses (wtv). wtv replication was inhibited by 5-bromodeoxyuridine, indicating the virus contained dna as its genetic material. virus infectivity could be transferred only as viable whole cell preparations; one cycle of r ... | 1975 | 1195504 |
| effect of povidone-iodine on herpesvirus type 2, in vitro. | povidone-iodine solution (betadine) at concentrations of 0.167% (v/v) reduced the end-point titers of strain e.m. herpesvirus, type 2, by more than 99.99%. even at concentrations of 0.0167% (v/v), povidone-iodine solution reduced the titers by 92%. the iodine solution, per se, had no effect on cultured human fibroblasts in concentrations of 1.67% (v/v). | 1975 | 1196555 |
| chlamydial infection in women with cervical dysplasia. | the prevalence of antibodies to chlamydiae, particularly to tric (trachoma-inclusion conjunctivitis) agents, was studied in women with cervical dysplasia and in women attending selected clinics (obstetrics, cancer-screening, and gynecology). in addition, attempts were made to isolate tric agents and herpesviruses from the cervices of these women. tric agent recovery rates 4.1 per cent for women with dysplasia, 5.4 per cent for pregnant women, 7.8 per cent in the women's clinic, and 0.8 per cent ... | 1975 | 1200069 |
| ultrastructural studies of semen abnormalities and herpesvirus associated with cultured testicular cells from domestic turkeys. | abnormal cells and macrophages found in white and yellow turkey semen were studied by electron microscopy. yellow semen contained many abnormal cells, most of which were large and round or smaller and ellipsoidal. it was concluded that they were aberrant spermatids, with differentiation being more complete in the smaller cells. only a few cells of the smaller type were detected in normal white semen. macrophages were occasionally seen in white semen but were numerous in yellow semen. phagocytic ... | 1975 | 1206622 |
| isolation and in vitro characterization of a herpesvirus from ground squirrels (citellus sp). | a viral agent was isolated from ground squirrel primary kidney cultures which presented a spontaneous cell layer alteration. the cultural, morphologic, and physico-chemical characteristics of the agent indicated that it belongs in the herpesvirus group. the isolate presented a narrow in vitro cell host range, growing best in marmoset monkey, owl monkey, rabbit, and hamster kidney cultures and poorly in vero and dog fetal lung cells. the agent is readily released from infected cells, a fact which ... | 1975 | 1207043 |
| characteristics of an ovine herpesvirus associated with pulmonary adenomatosis (jaagsiekte) in sheep. | the isolation of an ovine herpesvirus from a cell culture of an adenomatous sheep lung is reported, confirming previous observations of a possible association of a herpesvirus with this tumour. some growth properties and morphological characteristics of the virus are described, as well as serological data supporting a possible relationship between tumour and virus. attempts to produce jaagsiekte by intratracheal injection of virus into lambs were unsuccessful, suggesting that a second factor may ... | 1975 | 1209391 |
| prevention of herpes keratoconjunctivitis in rabbits by silver sulfadiazine. | silver sulfadiazine, at a concentration of 10 mug/ml when applied immediately after infection by herpesvirus hominis, prevented the development of acute herpetic keratoconjunctivitis in rabbits. the efficacy was inversely related to the size of inoculum. subclinical infections were observed in the drug-treated eyes. | 1975 | 1211919 |
| [experimental herpetic infection in rabbits combined with immunodepression (author's transl)]. | the immunologic response to herpesvirus infection have been studied in rabbits receiving azathioprine before, after or simultaneously with the infection. the part of humoral depression in the complications following human kidney graft and the meaning of the viral antibodies rises in these patients are discussed. | 1975 | 1217787 |
| [development of optimal conditions for isolation of rhinoviruses]. | when 366 dispensary patients with respiratory diseases were examined in moscow during the period december 1969--may 1971, 49 strains of rhinoviruses were isolated out of which 21 strains were identified as type 48. using eagle's medium with a single set of amino acids and vitamins for isolation rhinoviruses were isolated in 4.7% of cases, empdoying eagle's medium with a double set of amino acids and vitamins in 16% of cases. virus isolation experiments were carried out in hela-bristol cell cultu ... | 1975 | 1220246 |
| efficacy of lyophilized turkey herpesvirus vaccine against marek's disease in broilers. | field trials involving approximately 1,250,000 chickens vaccinated with cell-free turkey herpesvirus (hvt) vaccine and 635,000 chickens vaccinated with cell-associated hvt vaccine howed both vaccines equally effective in reducing condemnations (attributable to marek's disease) at the poultry processing plant. vaccinated chickens were progeny of hens vaccinated at 1 day of age with cell-associated hvt vaccine. the maternal antibody did not interfere with the ability of either the cell-free or cel ... | 1975 | 1228717 |
| failure to reproduce the cytopathic effect and chorioallantoic membrane reactions of the so-called smon herpesvirus. | 1975 | 1241397 | |
| experimental latent herpesvirus infection in rabbits, mice and hamsters: ultrastructure of the virus activation in explanted gasseric ganglia. | the frequency of latent infection as established in trigeminal ganglia of rabbits, mice and hamsters with human herpesvirus type 1 (hvh) was compared using two different virus strains. explantation proved to be effective in reisolation of hvh from ganglion tissue, which did not yield infectious virus at time of its removal. after healing of acute keratitis, the latent infection in homolateral gasseric ganglia of rabbits was detected at a relatively high frequency (60-80 per cent) up to 120 days ... | 1975 | 235193 |
| duck viral enteritis (duck plague) characteristics and immune response of the host. | duck viral enteritis (dve) is caused by a herpesvirus whose biologic and physical characteristics are similar to those described for the group of herpesviruses. only one immunologic and serologic type is known. a low level of neutralizing antibodies is developed in waterfowl vaccinated with the chicken embryo attenuated dve virus. a marked anamnestic serologic response resulted from challenge with virulent virus. waterfowl resisting exposure with virulent virus were solidly immune. however, wate ... | 1975 | 235868 |
| herpesvirus-induced availability of host dna to exogenous endonuclease. | deoxyribonuclease i penetrates herpesvirus-infected l cells and degrades host dna without interfering with viral multiplication. the dna of uninfected control monolayers of l cells, disrupted by scraping, is similarly attacked. in contrast, undisturbed l cells are not affected. this suggests that altered cell membrane permeability allows the nuclease to enter the cell, thereby permitting access of exogenous deoxyribonuclease to cellular dna. | 1975 | 241244 |
| repetitive sequences in complete and defective genomes of herpesvirus saimiri. | two types of herpesvirus saimiri genomes can be isolated from purified virions: (i) the m genome is a double-stranded, liniear dna molecule with a mean contour length corresponding to 89 times 10-6 daltons. the m genome contains about 70% of unique sequences (light dna, 36% guanine plus cytosine) and 30% reiterated sequences (heavy dna, 71% guanine plus cytosine). (ii) the h genome is composed of heavy dna only and is more heterogeneous in size. the sequences in the h genome are up to 40-fold re ... | 1975 | 803569 |
| effect of maternal immunity against development of marek's disease and protective ability of vaccine. | experiments were conducted to determine the susceptibility of chicks to marek's disease and the protective effect of the vaccine prepared from herpesvirus of turkey (hvt) on progeny from dams infected with marek's disease virus (mdv), or hvt, or both when they were young. chicks from dams infected with mdv or hvt-mdv were protected from the development of marek's disease when challenged at 3 days of age. the degree of protection decreased when the time of challenge was delayed; no protection was ... | 1975 | 804667 |
| a killed vaccine derived from the oncogenic herpesvirus ateles. | a killed herpesvirus vaccine was prepared by inactivation of the oncogenic herpesvirus ateles (hva) with heat and formaldehyde. the vaccine proved safe in 9 marmosets (saguinus oedipus) during a period of 461 days. the vaccinated marmosets developed high titers of serum antibodies against hva and were resistant to 316 lethal dose 50 (ld50) cell-free hva; the nonvaccinated control monkeys died of malignant lymphoma. the 5 challenged monkeys are clinically well and have now been under observation ... | 1975 | 808642 |
| transformation in vitro with herpesvirus ateles. | continuous lymphoblastoid cell cultures were established after transformation invitro with hva of marmoset splenic or circulating lymphocytes. transformation was achieved by co-cultivating lymphocytes with lethally x-irradiated, hva-carrying cells (derived originally from tumour cells of a marmoset experimentally infected with hva) or by infecting marmoset lymphocytes with cell-free virus. tenty-eight continous cultures from 39 that underwent co-cultivation and two of four lymphocyte preparation ... | 1975 | 828140 |
| marek's disease herpesviruses i. production and preliminary characterization of marek's disease herpesvirus a antigen. | a method was developed for the large-scale production of marek's disease herpesvirus a antigen in duck embryo fibroblast roller bottle cultures in quantities sufficient to permit its purification and characterization. maximum yield was obtained in serum-free culture medium harvested daily. the marek's disease herpesvirus a antigen was stable at ph 2.0 and was a glycoprotein based on its sensitivity to trypsin, specific immune co-precipitation of radioactive amino acids and glucosamine, and detec ... | 1975 | 16789152 |
| marek's disease herpesviruses ii. purification and further characterization of marek's disease herpesvirus a antigen. | marek's disease herpesvirus a antigen was purified greater than 200-fold with a 24% recovery by ion exchange column chromatography, isoelectric focusing, and preparative polyacrylamide gel electrophoresis. the antigen had an isoelectric point of 6.68 +/- 0.03 in the presence of 1 m urea and 0.05% brij 35, a nonionic detergent, and approximately 6.5 in the absence of dissociating agents. when analyzed by electrophoresis on analytical polyacrylamide gels, the purified antigen migrated as a single ... | 1975 | 16789153 |
| differentiation between strains of marek's disease virus and turkey herpesvirus by immunofluorescence assays. | two serological types of marek's disease virus and a herpesvirus of turkeys have been differentiated by indirect immunofluorescence tests as (1) pathogenic strains of marek's disease virus (mdv) and their attenuated variants: hprs-16, hprs-16/att, hprs-b14, jm, jm/att, ga, vc and 'oldenburg', a recent field isolate; (2) apathogenic strains hprs-24 and hprs-27 of mdv; (3) herpesvirus of turkeys strain fc126 and its hvt(a-) variant. virus strains could not be distinguished on the basis of qualitat ... | 1975 | 18777301 |
| precipitating antigens associated with marek's disease viruses and a herpesvirus of turkeys. | precipitating antigens associated with a number of marek's disease virus strains and with a turkey herpesvirus have been analyzed. the 'a' antigen has been defined as the major soluble antigen in feather follicles of infected chickens, which is identical with the major antigen usually present in supernatants of chicken kidney cell cultures infected with strains of marek's disease virus. 'bc' antigens are 2 or more antigens which are usually not noted in skin extracts but present in cultured cell ... | 1975 | 18777302 |
| [a method for partial purification of marek's disease herpesvirus a-antigen from feather follicles of infected chicken]. | a method for partial purification of marek's disease herpesvirus a antigen from feather follicles of infected chickens is described. the a antigen partially purified by ph 4 treatment and affinity chromatography when analyzed in polyacrylamide gel electrophoresis was found to be a mixture of 7 coomassie blue stained fractions. | 1976 | 18777347 |
| the effect of marek's disease vaccination on the immunisation of day-old chicks against newcastle disease, using b1 and oil emulsion vaccine. | concurrent vaccination of one-day-old chicks with 2 x 10(5) 50% embryo infectious doses of live b1 newcastle disease virus and 0.25 ml killed oil emulsion newcastle disease vaccine produced satisfactory levels of circulating haemagglutination inhibiting antibody although the recipient chicks possessed titres of maternally derived antibody as high as 10 log(2). this effect was also seen when the chicks were given turkey herpesvirus for immunisation against marek's disease. the satisfactory newcas ... | 1976 | 18777359 |
| experimental studies on the aetiology of inclusion body hepatitis. | liver suspensions and an adenovirus isolated from typical cases of inclusion body hepatitis (ibh) were inoculated into specific pathogen free birds by a combined oral and intranasal route but no pathological changes resulted. representative strains of 8 serotypes of avian adenoviruses from naturally occurring cases of ibh and non-hepatitis origins were inoculated intramuscularly into birds. the pathogenicity of these strains was studied and it was established that different strains produced diff ... | 1976 | 18777362 |