| nontuberculous mycobacteria. i: multicenter prevalence study in cystic fibrosis. | nontuberculous mycobacteria (ntm) are potential respiratory pathogens in cystic fibrosis (cf). to assess the species-specific prevalence and risk factors for acquisition, we conducted a prospective, cross-sectional study of the prevalence of ntm and clinical features of patients at 21 u.s. centers. almost 10% of patients with cf who were 10 years or older were included (n = 986). the overall prevalence of ntm in sputum was 13.0% (range by center, 7-24%). mycobacterium avium complex (72%) and myc ... | 2003 | 12433668 |
| evaluation of a commercial line probe assay for identification of mycobacterium species from liquid and solid culture. | the performance of a commercial line probe assay (lipa) (inno-lipa mycobacteria; innogenetics, belgium) for the detection and identification of mycobacterium species from liquid and solid culture was evaluated at five routine clinical laboratories. the lipa method is based on the reverse hybridization principle, in which the mycobacterial 16s-23s ribosomal rna (rrna) spacer region is amplified by polymerase chain reaction (pcr). amplicons are subsequently hybridized with oligonucleotide probes a ... | 2002 | 12461589 |
| outbreak of infection with mycobacterium abscessus: is sodium dodecyl sulfate-polyacrylamide gel electrophoresis a useful technique for epidemiological typing? | | 2003 | 12574318 |
| effects of ortho-phthalaldehyde, glutaraldehyde and chlorhexidine diacetate on mycobacterium chelonae and mycobacterium abscessus strains with modified permeability. | the mechanisms of the mycobactericidal action of ortho-phthalaldehyde (opa), glutaraldehyde (gta) and chlorhexidine diacetate (cha) were investigated using mycobacterial spheroplasts of two reference strains, mycobacterium chelonae nctc 946, mycobacterium abscessus nctc 10882 and two gta-resistant strains, m. chelonae epping and m. chelonae harefield. transmission electron microscopy of the spheroplasts revealed an altered cell wall structure compared with the parent cells. structural alteration ... | 2003 | 12615857 |
| [nontuberculous mycobacterial keratitis: report of two cases causing infectious crystalline keratopathy]. | we report two cases of nontuberculous mycobacterial keratitis, occurring after corneal trauma with superficial foreign body and after perforating keratoplasty for alkali burn, respectively. patients initially presented with indolent white corneal infiltrates, which did not respond to topical treatment. both secondarily developed infectious crystalline keratopathy with unequal intensity. in the first case, the excised flap of lamellar keratectomy was cultured, allowing identification of mycobacte ... | 2003 | 12660593 |
| forty years of disinfectant failure: outbreak of postinjection mycobacterium abscessus infection caused by contamination of benzalkonium chloride. | benzalkonium chloride (bc) continues to be used as an antiseptic and contributes to serious outbreaks of disease. in july 1999, 6 postinjection joint infections caused by mycobacterium abscessus were reported to the texas department of health (austin). we investigated this outbreak and identified 12 case patients who had been seen by the same physician and who had received an intra-articular or periarticular steroid injection during the period of 1 april through 31 july 1999. m. abscessus was cu ... | 2003 | 12684906 |
| [a mycobacterium abscessus infection complicated with lipoid pneumonia]. | a 64-year-old man was admitted to our hospital because of productive cough and fever. chest radiography on admission revealed air space consolidation in the right middle and lower lung fields and ground-glass opacity in the left middle lung field. he had been constipated for several years and had taken mineral oil for about a year. sputum smears demonstrated acid bacilli, and cultures disclosed mycobacterium abscessus. the transbronchial lung biopsy specimen showed granulomatous inflammation and ... | 2003 | 12692999 |
| rapidly growing mycobacterial infections after pedicures. | rapidly growing mycobacteria (rgm) can cause a variety of cutaneous and systemic diseases. the causative organisms are typically mycobacterium fortuitum or mycobacterium chelonae (also known as mycobacterium abscessus). primary cutaneous lesions may develop after a variable latent period, from weeks to several months, and usually result from direct inoculation after trauma, from injections, or during surgery via contaminated medical instruments. recently, investigators from the centers for disea ... | 2003 | 12756100 |
| radiographic and ct findings of nontuberculous mycobacterial pulmonary infection caused by mycobacterium abscessus. | objective: the purpose of our study was to describe the radiographic and ct findings in patients with pulmonary infections caused by mycobacterium abscessus, one of the more common rapidly growing nontuberculous mycobacteria that cause lung disease. conclusion: the main radiologic and ct manifestations of m. abscessus lung infection are bilateral small nodular opacities, bronchiectasis, and cavity formation. | 2003 | 12876037 |
| outbreak of mycobacterium abscessus infection after soft tissue augmentation. | illicit soft-tissue augmentation performed in new york city resulted in an outbreak of mycobacterium abscessus infection in 2002. | 2003 | 12930343 |
| an unusual acid-fast infection of the knee with subcutaneous, abscess-like lesions of the gluteal region; report of a case with a study of the organism, mycobacterium abscessus, n. sp. | | 1953 | 13035193 |
| [a case of lung infection due to mycobacterium abscessus]. | we report a case of lung infection due to mycobacterium abscessus (m. abscessus). a 60 year-old woman was admitted to our hospital because of an abnormal shadow found on chest radiography and a bloody sputum. chest radiography revealed infiltrative and linear shadows in the middle and lower fields of both lungs. the sputum smears were negative for acid-fast bacilli, but sputum culture was positive. rapidly growing mycobacteria were detected. the patient was treated with clarithromycin. since m. ... | 2003 | 14503341 |
| [investigation of drug-resistance to rifampin and rpob gene sequence analysis of mycobacterium abscessus]. | to observe the resistance of mycobacterium abscessus to rifampin and to investigate if there is any mutation of rpob gene in strains with high minimal inhibitory concentration (mic). | 2003 | 14521758 |
| [activity of cephems and carbapenems against clinically isolated mycobacterium abscessus]. | to screen effective useful drugs for disease due to m. abscessus, we determined mic of 3 cephems [ceftazidime (caz), cefoxitin (cfx), flomoxef (fmox)] and 3 carbapenems [imipenem (ipm), panipenem (papm), meropenem (mepm)] for 8 strains of clinically isolated m. abscessus by micro-dilution method using mgit system. in all the 8 strains, mics of caz are higher than 32 micrograms/ml. mic50, mic90, mic range of cfx are 32 micrograms/ml, > 32 micrograms/ml and 16- > 32 micrograms/ml respectively, and ... | 2003 | 14577345 |
| identifying mycobacterium species and strain typing using a microfluidic labchip instrument. | we developed schemes for rapid identification of mycobacterium species and strain typing using a microfluidic labchip instrument. a 439-bp region of the gene that codes for the 65-kda heat shock protein (hsp65), which has sequence polymorphisms specific for most mycobacterial species, was examined using pcr-restriction analysis (pra). we performed pra in duplicate, using 2 strains each of 12 species, and observed that fragment sizes (bp) determined automatically by the instrument were consistent ... | 2003 | 14579744 |
| foreign-body reaction with mycobacterium abseccus superinfection. | mycobacterium abscessus is a rare cause of skin and soft tissue infections that often results from inoculation with contaminated foreign material. a 41-year-old woman is described regarding an outbreak of m. abscessus following soft tissue augmentation. clinical features and treatment options are reviewed. | 2003 | 14594602 |
| rpob-based identification of nonpigmented and late-pigmenting rapidly growing mycobacteria. | nonpigmented and late-pigmenting rapidly growing mycobacteria (rgm) are increasingly isolated in clinical microbiology laboratories. their accurate identification remains problematic because classification is labor intensive work and because new taxa are not often incorporated into classification databases. also, 16s rrna gene sequence analysis underestimates rgm diversity and does not distinguish between all taxa. we determined the complete nucleotide sequence of the rpob gene, which encodes th ... | 2003 | 14662964 |
| endophthalmitis caused by mycobacterium abscessus. | to describe the clinical and laboratory features of a case of endophthalmitis caused by mycobacterium abscessus in a patient immunocompetent. | 2003 | 14700104 |
| mycobacterium abscessus and children with cystic fibrosis. | we prospectively studied 298 patients with cystic fibrosis (mean age 11.3 years; range 2 months to 32 years; sex ratio, 0.47) for nontuberculous mycobacteria in respiratory samples from january 1, 1996, to december 31, 1999. mycobacterium abscessus was by far the most prevalent nontuberculous mycobacterium: 15 patients (6 male, 9 female; mean age 11.9 years; range 2.5-22 years) had at least one positive sample for this microorganism (versus 6 patients positive for m. avium complex), including 10 ... | 2003 | 14720400 |
| therapeutic keratectomy for mycobacterium abscessus keratitis after lasik. | we report successful treatment of a case of mycobacterium abscessus keratitis after laser in situ keratomileusis (lasik) with therapeutic lamellar keratectomy. a 34-year-old woman developed a 2 x 2 mm feathery infiltration within the interface inferior to the pupil margin with mild inflammation of the conjunctiva in her left eye 40 days after lasik surgery. bacterial culture from the infiltrates of the interface of the stromal bed revealed mycobacterium abscessus. after combination antibiotic th ... | 2003 | 14724729 |
| mycobacterium abscessus cellulitis and multifocal abscesses of the breasts in a transsexual from illicit intramammary injections of silicone. | we report the case of a 29-year-old transsexual who developed mycobacterium abscessus infection after receiving intramammary liquid silicone injections in the nonphysician office setting. our patient represents 1 of 14 confirmed and 11 suspected cases in new york city of m abscessus infection after illicit cosmetic procedures. as injectable cosmetic procedures are becoming increasingly popular, dermatologists should be aware of both the common and unusual complications. furthermore, all physicia ... | 2004 | 14988690 |
| discontinuation of secondary prophylaxis in aids patients with disseminated non-tuberculous mycobacteria infection. | from june 1994 to june 2002, disseminated infections due to non-tuberculous mycobacteria (ntm) were diagnosed in 42 of 716 (5.9%) non-haemophiliac hiv-infected patients aged > or =15 years who were treated at national taiwan university hospital. the median age of these patients was 35 years (range, 27 to 60 years). the median cd4+ cell count and plasma viral load at the time of diagnosis of disseminated ntm infections were 8 x 10(6)/l (range, 0 to 892 x 10(6)/l) and 37,600 copies/ml (range, <400 ... | 2004 | 15060688 |
| nontuberculous mycobacterial pulmonary infection in immunocompetent patients: comparison of thin-section ct and histopathologic findings. | to identify and describe the thin-section computed tomographic (ct) findings of nontuberculous mycobacterial (ntm) pulmonary infection in immunocompetent patients and to compare these findings with histopathologic findings. | 2004 | 15118112 |
| subcutaneous infection with mycobacterium abscessus in a renal transplant recipient. | transplant recipients show a high incidence of infections, often with atypical manifestations mainly because of drug-related immunosuppression. mycobacterial infections can be life-threatening in immunosuppressed patients due to the risk of dissemination. there have been only few reports of cutaneous infections with mycobacterium abscessus among immunosuppressed patients. we present a rare case with a sporotrichoid skin infection with m. abscessus in a renal recipient. the value of immunohistoch ... | 2004 | 15118383 |
| [a case of lung infection due to mycobacterium abscessus (m. abscessus) complicated with primary macroamylasemia]. | we report a case of lung infection due to mycobacterium abscessus (m. abscessus), complicated with primary macroamylasemia. a 76-year-old man was admitted to our hospital in august 2002 because of bloody sputum and an abnormal shadow found on chest radiography. the patient had had pulmonary tuberculosis from 1998 to 2000. he was found to be antacid bacillus-positive (gaffky 5) on examination of the sputum in august 2002, but after hospitalization was negative for tuberculosis bacillus on sputum ... | 2004 | 15228140 |
| lightcycler-based differentiation of mycobacterium abscessus and mycobacterium chelonae. | in this study we introduce a rapid procedure to identify mycobacterium abscessus (types i and ii) and m. chelonae using lightcycler-based analysis of the hsp65 gene. results from 36 clinical strains were compared with hsp65 gene restriction analysis and biochemical profiles of bacilli. as all three methods yielded identical results for each isolate, this procedure offers an excellent alternative to previously established nucleic acid amplification-based techniques for the diagnosis of mycobacter ... | 2004 | 15243094 |
| pneumonectomy for nontuberculous mycobacterial infections. | pneumonectomy is considered in the treatment of nontuberculous mycobacterial infections when an entire lung is affected. however, this procedure carries high morbidity. we report on our experience in using pneumonectomy for treating patients with nontuberculous mycobacterial infections. | 2004 | 15276484 |
| late-onset mycobacterium abscessus sepsis in a very low birthweight premature infant: diagnostic and therapeutic challenges. | late-onset sepsis (after 3 days of life) is a frequent a complication found in very low birth weight (vlbw, 1000 to 1500 g) premature infants. we report the second case of late-onset sepsis caused by an uncommon pathogen, mycobacterium abscessus. | 2004 | 15311374 |
| reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin b6. | we sought to determine if vitamin b6 therapy would reverse linezolid-associated cytopenias and/or peripheral neuropathy. | 2004 | 15317746 |
| a novel mutation in ifn-gamma receptor 2 with dominant negative activity: biological consequences of homozygous and heterozygous states. | we identified two siblings homozygous for a single base pair deletion in the ifn-gammar2 transmembrane domain (791delg) who presented with multifocal mycobacterium abscessus osteomyelitis (patient 1) and disseminated cmv and mycobacterium avium complex infection (patient 2), respectively. although the patients showed no ifn-gammar activity, their healthy heterozygous parents showed only partial ifn-gammar activity. an hla-identical bone marrow transplant from the mother led patient 1 to complete ... | 2004 | 15356149 |
| microbiological identification in cystic fibrosis patients with cftr i1234v mutation. | recurrent and chronic bacterial pulmonary infection is the major cause of morbidity and mortality in cystic fibrosis (cf). over 6 months, 72 sputa or oropharyngeal samples were examined from 36 arab bedouin cf patients attending hamad general hospital, doha, qatar. more than 100 pathogens were isolated, mostly haemophilus influenzae, staphylococcus aureus and pseudomonas aeruginosa. unusual pathogens included stenotrophomonas maltophilia, acaligenes xylosoxidans and mycobacterium abscessus. it i ... | 2004 | 15357563 |
| mycobacterium abscessus as a cause of pacemaker infection. | mycobacterial infections of a pacemaker insertion site are very rare clinical events. such infections are caused primarily by staphylococci and streptococci and, less frequently, gram-negative organisms. | 2004 | 15448601 |
| performance assessment of a nested-pcr assay (the rapid bap-mtb) and the bd probetec et system for detection of mycobacterium tuberculosis in clinical specimens. | the performance of a nested pcr-based assay (the rapid bap-mtb; asiagen, taichung, taiwan) and the bd probetec et (dtb) system (becton dickinson, sparks, md.) for detection of mycobacterium tuberculosis was evaluated with 600 consecutive clinical samples. these samples, including 552 respiratory specimens and 48 nonrespiratory specimens, were collected from 333 patients treated at national taiwan university hospital from september to october 2003. the results of both assays were compared to the ... | 2004 | 15472315 |
| [a case of bronchial ulcer due to infection by mycobacterium abscessus]. | we present a rare case of tracheobronchitis caused by mycobacterium abscessus. the patient was a 79-year-old man with a previous history of tuberculosis. for smear examinations, he repeatedly expectorated many acid-fast bacilli. bronchoscopic examination revealed the presence of ulceration on the lower end of the trachea and extending to the right main bronchus. mycobacterial cultures were used to grow mycobacterium abscessus. following an antimicrobial regimen of clarithromycin, amikacin, and c ... | 2004 | 15566008 |
| amoebal coculture of "mycobacterium massiliense" sp. nov. from the sputum of a patient with hemoptoic pneumonia. | a nonphotochromogenic, rapidly growing mycobacterium strain was isolated in pure culture from the sputum and the bronchoalveolar fluid of a patient with hemoptoic pneumonia by using axenic media and an amoebal coculture system. both isolates grew in less than 7 days at 24 to 37 degrees c with an optimal growth temperature of 30 degrees c. the isolates exhibited biochemical and antimicrobial susceptibility profiles overlapping those of mycobacterium abscessus, mycobacterium chelonae, and mycobact ... | 2004 | 15583272 |
| pulsed-field gel electrophoresis study of mycobacterium abscessus isolates previously affected by dna degradation. | dna degradation (which results in a smear pattern) occurs with almost 50% of mycobacterium abscessus strains during pulsed-field gel electrophoresis (pfge). we assessed the potential benefit of using thiourea-containing buffer with m. abscessus by studying 69 isolates not previously typeable by pfge (i.e., those with a smear pattern). random (epidemiologically unrelated) isolates that were typeable (no smear pattern) were included as controls. genomic dna was digested with drai, xbai, and asei. ... | 2004 | 15583285 |
| measurement of immunoglobulin g against mycobacterial antigen a60 in patients with cystic fibrosis and lung infection due to mycobacterium abscessus. | the diagnosis and prognosis of lung infections due to the emerging nontuberculous mycobacterium (ntm) mycobacterium abscessus are difficult to establish in children with cystic fibrosis. | 2004 | 15614693 |
| disseminated mycobacterium abscessus infection in a hemodialysis patient with acquired reactive perforating collagenosis--a case study and literature review. | | 2005 | 15678699 |
| a new method for species identification and differentiation of mycobacterium chelonae complex based on amplified hsp65 restriction analysis (ahspra). | members of the mycobacterium chelonae complex (mcc), namely m. chelonae, mycobacterium abscessus and mycobacterium immunogenum, have been implicated in nosocomial infections and occupational respiratory illnesses like hypersensitivity pneumonitis (hp) associated with contaminated metalworking fluid (mwf) exposures. close relationship among these member species makes their differentiation cumbersome using the existing methods. here we report a simple and rapid method for unambiguous identificatio ... | 2004 | 15680210 |
| nontuberculous mycobacteria in cystic fibrosis associated with allergic bronchopulmonary aspergillosis and steroid therapy. | nontuberculous mycobacterial (ntm) infection, particularly due to mycobacterium abscessus, is an emerging disease that can be relentlessly progressive, particularly in cystic fibrosis (cf) patients. the risk factors that were associated with this increasingly symptomatic infection in a group of cf patients were investigated. a total of 139 cf patients aged 2-52 yrs were reviewed. sputum was cultured for ntm annually or whenever clinical deterioration was unexplained. in total, 12 patients (8.6%) ... | 2005 | 15684298 |
| bilateral bronchiectasis and bronchiolitis at thin-section ct: diagnostic implications in nontuberculous mycobacterial pulmonary infection. | to determine frequency of nontuberculous mycobacterial (ntm) pulmonary infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (ct) and whether ct findings are indicative of mycobacterium avium-intracellulare complex (mac) infection. | 2005 | 15703315 |
| multicenter evaluation of mycobacteria identification by pcr restriction enzyme analysis in laboratories from latin america and the caribbean. | the identification of mycobacterial species in clinical isolates is essential for making patient care decisions. polymerase chain reaction (pcr) restriction enzyme analysis (pra) is a simple and rapid identification method, based on amplification of 441 bp of the hsp65 gene and restriction with bsteii and haeiii. as a contribution to the validation of pra, a multicenter study was performed in eight laboratories located in argentina, brazil, colombia, chile, and guadeloupe. each laboratory receiv ... | 2004 | 15722145 |
| cutaneous mycobacterium abscessus infection after kidney transplantation. | | 2005 | 15755761 |
| rapid species identification within the mycobacterium chelonae-abscessus group by high-resolution melting analysis of hsp65 pcr products. | polymerase chain reaction (pcr) amplification of the heat shock protein 65 (hsp65) gene followed by high-resolution melting analysis with lcgreen i (idaho technology, salt lake city, ut) was used to differentiate the mycobacteria species mycobacterium chelonae, mycobacterium abscessus, and mycobacterium immunogenum in less than 20 minutes. a 105-base-pair amplicon that clustered the different species by predicted melting temperature was found from available genbank hsp65 sequences. we identified ... | 2005 | 15762284 |
| nontuberculous mycobacterial infection in young children with cystic fibrosis. | although nontuberculous mycobacteria (ntm) are recognized pathogens in adolescent and adult patients with cystic fibrosis (cf), the role of ntm in younger cf patients is not well-defined. to explore ntm infection in cf patients less than 12 years old, a retrospective review was performed. prevalence was estimated from routine mycobacterial cultures of bronchoalveolar lavage (bal) specimens collected over a 3-year period. ntm-positive cultures were obtained from 9 of 258 bals collected from 7 of ... | 2005 | 15858802 |
| nontuberculous mycobacterial exit-site infection and abscess in a peritoneal dialysis patient. a case report and review of the literature. | nontuberculous mycobacterial infections of peritoneal dialysis catheter exit sites have rarely been reported in patients on peritoneal dialysis. we report here a case of mycobacterium abscessus exit site infection with abdominal wall abscess formation in an adolescent on peritoneal dialysis, which required long-term antibiotic therapy, peritoneal dialysis catheter removal, and surgical debridement of the abscess. nontuberculous mycobacteria should be considered as a possible causative organism f ... | 2005 | 15880270 |
| [pulmonary infection caused by non-tuberculous mycobacteria in two patients with bronchiectasis]. | two patients, a woman aged 67 years and a man aged 80 years, had chronic cough among other respiratory symptoms. in the woman, chest radiograph and ct-scan revealed partial atelectasis of the middle lobe and bronchiectasis. in the man, an interstitial pattern was seen on chest radiograph, and ct scan showed diffuse bronchiectasis. in both the man and the woman, non-tuberculous mycobacteria were identified (mycobacterium avium complex and mycobacterium abscessus, respectively). treatment was succ ... | 2005 | 15903035 |
| completion pneumonectomy for chronic mycobacterial disease. | patients with persistent pulmonary infections from mycobacterial disease present a difficult clinical challenge. these individuals typically have poor pulmonary function, malnutrition, and other comorbidities, and few guidelines exist regarding optimal therapy. we report our experience with completion pneumonectomy as part of a multidisciplinary treatment program for patients with recurrent, persistent mycobacterial disease. | 2005 | 15942565 |
| osteomyelitis of the mandible due to mycobacterium abscessus: a case report. | | 2005 | 15944984 |
| [two cases of pulmonary infection by mycobacterium abscessus in which drug susceptibility testing results conflicted with clinical courses]. | we encountered two cases of pulmonary infection by mycobacterium abscessus (m. abscessus). [case 1] a 66-year-old man who had been treated for non-tuberculous mycobacterium in the past was admitted because of productive cough. his chest x-ray film showed cavitation and direct microscopy of sputum revealed positive acid-fast bacilli (afb). he was given rifampicin (rfp), ethambutol (eb), and clarythromycin (cam), and then his symptoms and radiographic findings improved. [case 2] a 74-year-old man ... | 2005 | 15966372 |
| mycobacteria abscessus outbreak in us patients linked to offshore surgicenter. | we recently encountered 5 patients with mycobacterium abscessus infection following cosmetic procedures performed at a surgicenter located off the united states coastline which, by report, actively recruits domestic patients. additional patients with similar clinical histories and presentation have been identified at other practices along the eastern seaboard as well. a recent centers for disease control and prevention investigation has confirmed a common link. all procedures were performed in s ... | 2005 | 15985802 |
| age-related prevalence and distribution of nontuberculous mycobacterial species among patients with cystic fibrosis. | we studied the prevalence and species distribution of nontuberculous mycobacteria (ntm) in relation to age in 385 patients with cystic fibrosis (cf) (mean age +/- standard deviation [range], 12.0 +/- 6.1 [1 to 24] years; sex ratio, 0.53) attending three parisian centers. the overall prevalence of ntm in sputum was 8.1% (31 out of 385). the following ntm were isolated (n = 33): mycobacterium abscessus (n = 13, 39.4%), mycobacterium avium complex (mac) (n = 7, 21.2%), mycobacterium gordonae (n = 6 ... | 2005 | 16000480 |
| intra- and interpatient variability of the hsp65 and 16s-23s intergenic gene region in mycobacterium abscessus strains from patients with cystic fibrosis. | to establish the exact pathogenic role of mycobacterium abscessus in cystic fibrosis (cf), molecular tests are required for accurate identification. forty-eight m. abscessus isolates from seven patients with cf were analyzed by sequence analysis for sequence variants within the hsp65 gene and the 16s-23s intergenic sequence (its). we detected two different hsp65 genes and correspondingly two its sequevars belonging to m. abscessus type i and type ii. | 2005 | 16000490 |
| nramp1 gene polymorphism and susceptibility to nontuberculous mycobacterial lung diseases. | pulmonary disease caused by nontuberculous mycobacteria (ntm) may occur in patients with no underlying lung disease and no known immunodeficiency. the purpose of this study was to evaluate a potential role for natural-resistance-associated macrophage protein 1 (nramp1) gene polymorphisms for human susceptibility to the ntm lung disease. | 2005 | 16002921 |
| mycobacterium abscessus and other nontuberculous mycobacteria: evolving respiratory pathogens in cystic fibrosis: a case report and review. | cystic fibrosis (cf) is a risk factor for the development of nontuberculous mycobacteria (ntm) infection. prevalence of these organisms varies from center to center with the predominance of affected patients being in the adult population. the difficulty in diagnosing ntm infection in cf involves the overlap between signs and symptoms of underlying cf lung disease with its variable pathogens and the signs and symptoms attributable to pulmonary disease caused by ntm. bacterial overgrowth, especial ... | 2005 | 16004174 |
| in vitro activity of fluoroquinolones against mycobacterium abscessus and mycobacterium chelonae causing infectious keratitis after lasik in brazil. | to evaluate the in vitro activity of fluoroquinolones against mycobacterium abscessus and mycobacterium chelonae isolated from outbreaks of infectious keratitis in brazil. | 2005 | 16015094 |
| infection with mycobacterium abscessus after mohs micrographic surgery in an immunocompetent patient. | nontuberculous mycobacterial infections are increasing in incidence. they have been reported following multiple procedures, including dialysis, liposuction, soft tissue augmentation, pedicures, public baths, acupuncture, placement of contaminated foreign devices such as the norplant (wyeth pharmaceuticals, collegetown, pa, usa), intravenous catheters, and during surgery from contamination of medical instruments. | 2005 | 16029710 |
| clinical, microbiological, and epidemiological findings of an outbreak of mycobacterium abscessus hand-and-foot disease. | in 2003, we identified an outbreak of clinically distinct lesions involving the hands and feet associated with a public wading pool in edmonton, alberta, canada. a total of 85 cases were identified. the management and follow-up of 41 children and 1 adult patients is presented. skin lesions occurred within a median incubation period of 29 days and approximately 88 days for the adult patient. lesions resolved within a median of 58 days and approximately 150 days for the adult patient. patients wer ... | 2005 | 16054324 |
| mycobacterium chelonae-mycobacterium abscessus complex clear corneal wound infection with recurrent hypopyon and perforation after phacoemulsification and intraocular lens implantation. | we report a clear corneal wound infection occurring in a 74-year-old man caused by a member of the mycobacterium chelonae-mycobacterium abscessus complex, presenting as crystalline keratopathy with recurrent hypopyon. this led to perforation after phacoemulsification with posterior chamber intraocular lens implantation. only after corneal biopsy of the incision was the causative organism isolated and found to be sensitive to clarithromycin and ciprofloxacin. despite aggressive therapy, a full-th ... | 2005 | 16105623 |
| pneumonia due to mycobacterium abscessus in two domestic ferrets (mustelo putorius furo). | two ferrets were diagnosed with pneumonia due to mycobacterium abscessus. both cases were treated successfully using clarithromycin after positive cultures were obtained via unguided bronchoalveolar lavage. this is the first time m abscessus has been isolated in our laboratory and the first report of this organism causing disease in companion animals in australia. underlying respiratory tract disease was thought to be an important factor in the development of the infections. thorough investigati ... | 2005 | 16164141 |
| iatrogenic mycobacterium abscessus infection associated with acupuncture: clinical manifestations and its treatment. | mycobacterial infections transmitted by acupuncture are an emerging problem. there have been two reports of mycobacterial infections complicating acupuncture in the english literature. | 2005 | 16207187 |
| thin-section ct findings of nontuberculous mycobacterial pulmonary diseases: comparison between mycobacterium avium-intracellulare complex and mycobacterium abscessus infection. | we aimed to compare the ct findings of nontuberculous mycobacterial pulmonary diseases caused by mycobacterium avium-intracellulare complex (mac) and mycobacterium abscessus. two chest radiologists analyzed retrospectively the thin-section ct findings of 51 patients with mac and 36 with m. abscessus infection in terms of patterns and forms of lung lesions. no significant difference was found between mac and m. abscessus infection in the presence of small nodules, tree-in-bud pattern, and bronchi ... | 2005 | 16224151 |
| mycobacterium abscessus infection after use of tumor necrosis factor alpha inhibitor therapy: case report and review of infectious complications associated with tumor necrosis factor alpha inhibitor use. | tumor necrosis factor alpha (tnf-alpha) inhibitors, such as infliximab and etanercept, are now frequently used in the treatment of inflammatory diseases including rheumatoid arthritis (ra) and crohn's disease. as an apparent result of their immune modulating activity, there has been an observed association between the use of these agents and the development of a wide range of infections, most notably mycobacterium tuberculosis. we describe a case of infection with mycobacterium abscessus in a 67 ... | 2005 | 16249064 |
| [nontuberculous mycobacteria in patients with cystic fibrosis]. | patients with cystic fibrosis are at great risk of infection by nontuberculous mycobacteria from the environment because of certain predisposing factors such as bronchiectasis, malnutrition, and diabetes. the aim of this study was to analyze the mycobacterial content of sputum smears and cultures from adult patients with cystic fibrosis attended at a specialized unit for adults from march 1997 through december 2001. | 2005 | 16266669 |
| deep stromal mycobacterial keratitis: viable bacteria after six months of treatment: case report and literature review. | to report the presence of viable mycobacteria in a patient with keratitis treated for 6 months. species identification was performed using the pra method (polymerase chain reaction followed by restriction endonuclease analysis). clonality was evaluated with rapd (randomly amplified polymorphic dna) and eric-pcr (enterobacterial repetitive intergenic consensus-polymerase chain reaction) methods. the patient reported trauma due to a metallic foreign body 3 weeks prior to presentation. initial corn ... | 2005 | 16322845 |
| sequence variant for internal transcribed spacer region of mycobacterium abscessus. | | 2005 | 16333135 |
| an outbreak of post-acupuncture cutaneous infection due to mycobacterium abscessus. | despite the increasing popularity of acupuncture, the importance of infection control is not adequately emphasized in oriental medicine. in december 2001, an oriental medical doctor in seoul, south korea, encountered several patients with persistent, culture-negative skin lesions on the trunk and extremities at the sites of prior acupuncture treatment. we identified and investigated an outbreak of mycobacterium abscessus cutaneous infection among the patients who attended this oriental medicine ... | 2006 | 16412228 |
| use of pcr-restriction fragment length polymorphism for the identification of zoonotic mycobacteriosis in zebrafish caused by mycobacterium abscessus and mycobacterium chelonae. | skin ulcers, scoliosis, and dropsy-like scale edema were observed in laboratory-maintained zebrafish. affected fish had multifocal granulomas not only in internal organs such as the liver, intestine, genital organs, kidney, muscle, and spleen but also in the fin, epithelium, gills, and sclera of the eyes. large numbers of acid-fast-rod-shaped bacteria were observed within the necrotic centers of well-demarcated, multifocal granulomas with gram's stain and ziehl-neelson's stain. the size of the m ... | 2006 | 16414212 |
| effectiveness of fluoroquinolones against mycobacterium abscessus in vivo. | to determine the effectiveness of fluoroquinolones against mycobacterium abscessus in vivo. | 2006 | 16421016 |
| clinical significance of nontuberculous mycobacteria isolated from respiratory specimens in korea. | precise epidemiologic data regarding nontuberculous mycobacterial (ntm) lung infection in many asian countries have been relatively unavailable. in order to determine the clinical significance of ntm isolated from respiratory specimens, we reviewed medical records from all patients from whom ntm isolates were recovered within a 2-year period. | 2006 | 16478850 |
| mycobacterium abscessus pulmonary infection presenting as a solitary pulmonary nodule. | nontuberculous mycobacterial pulmonary infection is a rare cause of a solitary pulmonary nodule. all previously reported cases were caused by mycobacterium avium complex, and a solitary pulmonary nodule caused by other ntm species has been very rarely reported. we describe the first case of mycobacterium abscessus infection presenting as a solitary pulmonary nodule in a 51-year-old asymptomatic adult patient. | 2006 | 16508233 |
| concomitant late soft tissue infections by cladophialophora bantiana and mycobacterium abscessus following tsunami injuries. | a swedish man and woman sustained severe soft tissue injuries during the tsunami catastrophe in thailand in december 2004, and subsequently received partial thickness skin grafts after multiple surgical revisions. four to six weeks post trauma they displayed signs of purulent infections in the non-traumatized, virtually intact skin outside the resection margins. skin biopsies revealed granulomatous reactions and pigmented fungal hyphae were observed in specimens from the male patient. cladophial ... | 2006 | 16519023 |
| enterobacterial repetitive intergenic consensus pcr is a useful tool for typing mycobacterium chelonae and mycobacterium abscessus isolates. | outbreaks of rapidly growing mycobacterium (rgm) infections are increasingly being reported worldwide. information about genetic relatedness of isolates obtained during outbreaks can provide opportunities for prompt intervention. pulsed-field gel electrophoresis (pfge) is expensive, time consuming, and labor intensive. other than that, mycobacterium abscessus isolates can suffer dna degradation during electrophoresis. polymerase chain reaction (pcr)-based methods are cheaper, faster, and easier ... | 2006 | 16529900 |
| non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation. | wc and ns contributed equally. non-tuberculous mycobacteria (ntm) frequently colonise patients with end stage cystic fibrosis (cf), but its impact on the course of the disease following lung transplantation is unknown. | 2006 | 16601086 |
| fatal pulmonary mycobacterium abscessus infection in a patient using etanercept. | a case of fatal pulmonary mycobacterium abscessus infection in a 56-year-old man is reported. the patient had a longstanding history of seropositive, nodular rheumatoid arthritis with severe joint manifestations that had been treated with a regimen of prednisone, leflunomide, and etanercept. he presented to our facility with complaint of productive cough, persistent fevers, pleuritic chest discomfort, and dyspnea at rest. the patient was admitted to hospital, placed in isolation, a left-sided ch ... | 2006 | 16602610 |
| abdominal nontuberculous mycobacterial infection in a university hospital in taiwan from 1997 to 2003. | abdominal nontuberculous mycobacterial infection is a rare condition. continuous ambulatory peritoneal dialysis (capd)-associated peritonitis is the most common manifestation of infection due to nontuberculous mycobacteria (ntm). there are limited data on the clinical manifestations of nontuberculous mycobacterial infection. this study investigated the diagnostic features, clinical presentation, mycobacteriology, treatment and outcome of all abdominal ntm infections treated over a 7-year period ... | 2006 | 16638646 |
| cutaneous infection with mycobacterium abscessus in a child. | nontuberculous mycobacteria can cause cutaneous infections in both children and adults. localized nontuberculous mycobacterial infections of the skin have been reported in children following injections or surgical procedures. we report a child who developed a cutaneous nontuberculous mycobacterial infection after exposure of a skin wound to pond water. cutaneous infection with the rapidly growing mycobacteria mycobacterium abscessus was demonstrated by clinical and histologic evaluation on the l ... | 2006 | 16650219 |
| partial interferon-gamma receptor deficiency and non-tuberculous mycobacterial lung disease. | interferon-gamma (ifn-gamma) plays a key role in the host defense response against mycobacterial disease, and a complete or partial deficiency in ifn-gamma receptor 1 (ifn-gammar1) or ifn-gamma receptor 2 (ifn-gammar2) has been reported to contribute to susceptibility to disseminated infection with non-tuberculous mycobacteria (ntm). however, ifn-gammar1 and ifn-gammar2 deficiencies have not yet been studied in adult patients with isolated ntm lung disease. the purpose of the present study was t ... | 2006 | 16682253 |
| infections due to rapidly growing mycobacteria. | rapidly growing mycobacteria, generally of low virulence, are capable of causing a wide spectrum of infections. increasing reports in the literature, referral center experiences, and data from the infectious disease society of america emerging infectious disease network suggest that greater numbers of infections are occurring. epidemiological study is imperative in understanding the true incidence of these infections and preventing disease in vulnerable hosts. especially problematic is pulmonary ... | 2006 | 16705584 |
| mycobacterium abscessus: an emerging rapid-growing potential pathogen. | mycobacterium abscessus is the most pathogenic and chemotherapy-resistant rapid-growing mycobacterium. it is commonly associated with contaminated traumatic skin wounds and with post-surgical soft tissue infections. it is also one of the mycobacteria that are most often isolated from cystic fibrosis patients. it is essential to differentiate this species from the formerly indistinct "m. chelonae-complex", as chemotherapy is especially difficult in m. abscessussenso strictu. clarithromycin or azi ... | 2006 | 16725007 |
| spontaneous reversion of mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype. | mycobacterium abscessus is an increasingly important cause of human disease; however, virulence determinants are largely uncharacterized. previously, it was demonstrated that a rough, wild-type human clinical isolate (390r) causes persistent, invasive infection, while a smooth isogenic mutant (390s) has lost this capability. during serial passage of 390s, a spontaneous rough revertant was obtained, which was named 390v. this revertant regained the ability to cause persistent, invasive infection ... | 2006 | 16735722 |
| [soft-tissue infections due to non-tuberculous mycobacteria following mesotherapy. what is the price of beauty]. | mesotherapy is widely used in latin america for cosmetic purposes, particularly in obese individuals. we describe the clinical and epidemiological characteristics, microbiological diagnosis, treatment and follow-up of patients from caracas (venezuela) with soft tissue infection caused by non-tuberculous mycobacteria following mesotherapy. | 2006 | 16762255 |
| mycobacterium abscessus keratitis after lasik with intralase femtosecond laser. | a healthy 38-year-old woman developed 2 white spots in her left eye 2 weeks after bilateral laser in situ keratomileusis (lasik) using the intralase femtosecond laser. initial treatment included levofloxacin 0.5% but was unsuccessful. the surgeon irrigated the interface and repositioned the flap due to a worsened lesion. she was referred to us after the keratitis had not improved. the flap was lifted for collection of the specimen and irrigation of the interface. the keratitis was treated with i ... | 2006 | 16785761 |
| cutaneous infection with rapidly-growing mycobacterial infection following heart transplant: a case report and review of the literature. | nontuberculous mycobacteria are ubiquitous and infrequently cause disease in humans, most commonly in immunocompromised hosts. one type of nontuberculous mycobacteria is mycobacterium abscessus. this rapidly growing mycobacterium is a soil or water saprophyte. it was previously classified as a subspecies of mycobacterium chelonae; however, current taxonomy now designates it as a separate species. rapidly growing mycobacteria are resistant to the usual antituberculous drugs. this emphasizes the n ... | 2006 | 16797350 |
| mycobacterium abscessus chest wall and pulmonary infection in a cystic fibrosis lung transplant recipient. | mycobacterial infections are increasingly recognized in cystic fibrosis (cf) patients before transplant; however, knowledge about the clinical significance or spectrum of infections observed with mycobacterial infections in lung transplant recipients is still evolving. herein, we report a case of infection with mycobacterium abscessus in a cf lung transplant recipient. despite aggressive treatment before and peri-operatively with anti-mycobacterial therapy, the patient developed skin and soft ti ... | 2006 | 16890122 |
| pathogenesis of mycobacterium spp. in zebrafish (danio rerio) from research facilities. | one of the most common diseases that we have diagnosed in zebrafish is mycobacteriosis, caused by several mycobacterium spp. the severity of the disease ranged from severe outbreaks to incidental infections. we conducted an in vivo study to evaluate the pathogenesis of six isolates of mycobacterium from zebrafish with mycobacteriosis from four research facilities and one wholesale supplier of zebrafish in the united states: mycobacterium abscessus, mycobacterium peregrinum, mycobacterium chelona ... | 2007 | 16904945 |
| mycobacterium abscessus cervical lymphadenitis: an immunocompetent child. | nontuberculous mycobacterium (ntm) is one of the well-known causes of cervicofacial lymphadenopathy in children under 5 years of age. children often present with a painless cervical mass that fails to respond to conventional antibiotics. they are often referred under the suspicion of a neoplasm or bacterial adenitis rather than ntm cervical lymphadenitis. the lack of systemic symptoms, modest or negative purified protein derivative test and absence of exposure to active tuberculosis are characte ... | 2006 | 16911925 |
| mycobacterium abscessus endophthalmitis: treatment dilemma and review of the literature. | | 2006 | 16963860 |
| polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and non-tuberculous mycobacterial lung diseases. | interferon-gamma (ifn-gamma) is crucial for host defense against mycobacterial infections. recent studies have indicated that ifn-gamma and ifn-gamma receptor 1 (ifn-gammar1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. the aim of this study was to test the hypothesis that ifn-gamma and ifn-gammar1 gene polymorphisms influence susceptibility to lung disease caused by non-tuberculous mycobacteria (ntm). seventy-six patients with the nodular bronchiectatic form ... | 2007 | 17023216 |
| skin and soft tissue infections due to rapidly growing mycobacteria: comparison of clinical features, treatment, and susceptibility. | to compare the demographics, clinical features, susceptibility patterns, and treatment for skin and soft tissue infections due to mycobacterium fortuitum and mycobacterium chelonae or mycobacterium abscessus. | 2006 | 17043183 |
| multiple subcutaneous nodules associate with mycobacterium abscessus infection following removal of an infected groshon vascular catheter tip. | a 41-year-old man with a history of septic right leg underwent a below-the-knee amputation. one month after amputation and removal of groshon catheter tip, he developed disseminated subcutaneous abscesses attributed to mycobacterium abscessus. | 2006 | 17083867 |
| pathological and molecular studies on mycobacteriosis of milkfish chanos chanos in taiwan. | investigated in milkfish chanos chanos, which had a cumulative mortality of up to 66.7% over the course of 1 yr. gross reddish- or greyish-white nodules appeared on the peritoneal surface, spleen, kidney, liver and gastrointestinal (gi) tract. epithelioid granulomas with the formation of langhan's type giant cells were the prominent histopathological changes. despite large numbers of acid-fast bacilli in the granulomas, neither caseous necrosis nor dystrophic calcification were observed. using d ... | 2006 | 17140137 |
| [a case of mycobacterium abscessus pulmonary infection; effectiveness of clarithromycin, amikacin and imipenem/cilastatin]. | a 42-year-old woman presented with persistent cough, bloody sputum and fever. her chest x-ray film showed an infiltrative shadow with cavitation in the upper lobe of the left lung. acid-fast-bacilli were shown by sputum smear staining. the anti-tuberculosis drugs isoniazid, refampicin, ethambutol and pyrazinamide were prescribed, but her symptoms and chest x-ray findings did not improve. findings of mtd and mac-pcr were negative but mycobacterium abscessus was confirmed by sputum culture with th ... | 2006 | 17144576 |
| hypervirulence of a rough variant of the mycobacterium abscessus type strain. | we isolated a rough variant of mycobacterium abscessus cip 104536t during experimental infection of mice. we show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for c57bl/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages. | 2007 | 17145951 |
| mycobacterium abscessus infections in lung transplant recipients: the international experience. | the clinical significance of mycobacterium abscessus infection in the lung transplant population is not well understood. | 2006 | 17178340 |
| outbreak of acupuncture-associated cutaneous mycobacterium abscessus infections. | cutaneous atypical mycobacterial infections have been increasingly described in association with cosmetic and alternative procedures. | 2006 | 17234114 |
| paradoxical worsening of pulmonary mycobacterium abscessus. | transient worsening of tuberculosis (tb) symptomatology and lesions in response to anti-tb therapy has previously been reported as paradoxical worsening. recently, paradoxical worsening of tb following antiretroviral therapy in aids patients was reported. however, paradoxical worsening of nontuberculous mycobacterium, including mycobacterium abscessus (m. abscessus), has not been reported previously. we reported the first case of paradoxical worsening of pulmonary m. abscessus. | 2007 | 17293101 |
| pulmonary infection with rapidly growing mycobacteria in a singer with achalasia: a case report. | we report the case of a 37-year-old male patient with prolonged pneumonia and achalasia. culture and molecular genetic typing identified mycobacterium abscessus as causative agent. treatment with clarithromycin and minocycline over 8 months gradually resolved the infection. rapidly growing, non-obligate pathogenic mycobacteria are widespread in the environment. several cases of pulmonary infections with these mycobacteria in patients with achalasia have been reported, suggesting a causative asso ... | 2007 | 17316814 |
| evaluation of bact/alert 3d sa bottles for accurate detection of mycobacteremia with special reference to mycobacterium abscessus. | bacteremia due to mycobacterium abscessus, a rapid grower, belonging to the runyon group iv, occurred in an inpatient with fever of unidentified origin in shinshu university hospital. to the best of our knowledge, this is the first documented case of m. abscessus bacteremia in japan. the organism initially grew on sheep blood agar plates after terminal-subculturing from the bact/alert sa aerobic blood culture bottles with no positive signal, and was subsequently identified as m. abscessus using ... | 2007 | 17363357 |
| molecular epidemiology of mycobacterium abscessus, with focus on cystic fibrosis. | mycobacterium abscessus has been isolated increasingly often from the respiratory tracts of cystic fibrosis (cf) patients. it is not known whether these organisms are transmitted from person to person or acquired from environmental sources. here, colony morphology and pulsed-field gel electrophoresis (pfge) pattern were examined for 71 isolates of m. abscessus derived from 14 cf patients, three non-cf patients with chronic respiratory m. abscessus infection or colonization, one patient with mast ... | 2007 | 17376883 |