Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| mycobacterium abscessus complex identification with matrix-assisted laser desorption ionization-time of flight mass spectrometry. | we determined that the vitek ms plus matrix-assisted laser desorption ionization-time of flight mass spectrometry using research-use-only (ruo) v.4.12 and in vitro-diagnostic (ivd) v.3.0 databases accurately identified 41 mycobacterium abscessus subsp. abscessus and 13 m. abscessus subsp. massiliense isolates identified by whole-genome sequencing to the species but not the subspecies level, from middlebrook 7h11 and burkholderia cepacia selective agars. peak analysis revealed three peaks potenti ... | 2015 | 25948607 |
| "you can't always get what you want…" the mycobacterium abscessus issue. name versus function. | 2015 | 25786149 | |
| epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in scandinavia. | nontuberculous mycobacteria (ntm) are an emerging threat to cystic fibrosis (cf) patients but their epidemiology is not well described. | 2015 | 25178871 |
| epidemiology of infection and current guidelines for infection prevention in cystic fibrosis patients. | the spectrum of bacterial pathogens encountered in cystic fibrosis (cf) lung disease has expanded over the last decade. in addition to established pathogens, such as pseudomonas aeruginosa, burkholderia cepacia complex and staphylococcus aureus, novel gram-negative non-fermenter bacteria and non-tuberculous mycobacteria have gained in clinical significance. air sampling performed in inpatient and outpatient clinics, and analysis of cough aerosols expelled by cf patients provides evidence for pot ... | 2015 | 25791927 |
| the challenge of pulmonary nontuberculous mycobacterial infection. | the incidence of nontuberculous mycobacterial (ntm) lung disease is increasing. current treatment strategies are largely based on expert opinion. the lack of randomized clinical trials to inform treatment leave clinicians with many questions regarding the most effective and safe regimens. the risk-benefit ratio of therapy is often thought to favor observation given the chronic nature of the disease, multiple long-term antibiotics recommended for therapy, side effects associated with treatment, a ... | 2015 | 26877911 |
| post liposuction mycobacterium abscessus surgical site infection in a returned medical tourist complicated by a paradoxical reaction during treatment. | rapidly growing mycobacterial skin and soft tissue infections are known to complicate cosmetic surgical procedures. treatment consists of more surgery and prolonged antibiotic therapy guided by drug susceptibility testing. paradoxical reactions occurring during antibiotic therapy can further complicate treatment of non-tuberculous mycobacterial infections. we report a case of post liposuction mycobacterium abscessus surgical site infection in a returned medical tourist and occurrence of paradox ... | 2015 | 26753088 |
| [detection of mutations in the gyra and gyrb genes associated with fluoroquinolone-resistance among clinical isolates of mycobacterium abscessus in china]. | to determine molecular mutations in gyra and gyrb genes and their association with fluoroquinone-resistance among mycobacterium abscessus isolates from china. | 2015 | 26703016 |
| high-throughput transcriptomics reveals common and strain-specific responses of human macrophages to infection with mycobacterium abscessus smooth and rough variants. | mycobacterium abscessus (mab) is an emerging pathogen causing pulmonary infections in those with inflammatory lung disorders, such as cystic fibrosis (cf), and is associated with the highest fatality rate among rapidly growing mycobacteria (rgm). phenotypically, mab manifests as either a smooth (mab-s) or a rough (mab-r) morphotype, which differ in their levels of cell wall glycopeptidolipids (gpls) and in their pathogenicity in vivo. as one of the primary immune cells encountered by mab, we sou ... | 2015 | 26654095 |
| amikacin pharmacokinetics/pharmacodynamics in a novel hollow-fiber mycobacterium abscessus disease model. | the treatment of pulmonary mycobacterium abscessus disease is associated with very high failure rates and easily acquired drug resistance. amikacin is the key drug in treatment regimens, but the optimal doses are unknown. no good preclinical model exists to perform formal pharmacokinetics/pharmacodynamics experiments to determine these optimal doses. we developed a hollow-fiber system model of m. abscessus disease and studied amikacin exposure effects and dose scheduling. we mimicked amikacin hu ... | 2015 | 26643339 |
| [sporadic cutaneous infections due to nontuberculous mycobacteria: a retrospective study of 37 cases]. | to study the clinical and pathological characteristics of sporadic cutaneous infections due to nontuberculous mycobacteria (ntm), and investigate the diagnostic criteria and therapeutic principal. | 2015 | 26679654 |
| mycobacterium abscessus in people with cystic fibrosis: considerations for psychosocial care. | 2015 | 26545769 | |
| antibiotic susceptibility of diverse mycobacterium abscessus complex strains in new south wales, australia. | members of the mycobacterium abscessus complex are emerging pathogens of increasing importance, causing both respiratory and soft tissue infections, but precise speciation is problematic. this study was performed to examine the subspecies and antibiotic susceptibility of m. abscessus complex isolates collected during 2013 at the statewide new south wales mycobacterium reference laboratory (nsw mrl), australia. mycobacterium abscessus subsp. abscessus accounted for more than half of all m. absces ... | 2015 | 26517625 |
| chronic pulmonary disease with mycobacterium abscessus complex is a biofilm infection. | 2015 | 26493807 | |
| [a case of pulmonary mycobacterium abscessus infection successfully treated with short-term cam, amk, and ipm/cs followed by long-term oral cam and lvfx]. | a 78-year-old woman who had been treated for two years with itcz for chronic pulmonary aspergillosis associated with prior pulmonary tuberculosis was admitted to our hospital because of general fatigue and hemosputum along with deterioration of her chest radiographic findings. mycobacterium abscessus had been isolated once from her sputum one year before admission. we performed fiberoptic bronchoscopy (fob) in order to help establish a final diagnosis. sputum aspirated from her bronchus on fob s ... | 2015 | 26489157 |
| [a study of surgical treatment for patients with mycobacterium abscessus pulmonary disease and a comparative examination of mycobacterium avium complex disease]. | this is a retrospective study on six surgical cases of mycobacterium abscessus pulmonary disease, including a comparison with m. avium complex (mac) disease. | 2015 | 26477110 |
| human infections due to nontuberculous mycobacteria: the infectious diseases and clinical microbiology specialists' point of view. | nontuberculous mycobacteria (>150 species such as mycobacterium avium, mycobacterium kansasii, mycobacterium chelonae and mycobacterium abscessus) are opportunistic pathogens causing lung and extrarespiratory infections, beside m. ulcerans and m. marinum that are pathogens causing specific skin and soft tissue infections. disseminated infections occur only in severe immunosuppressed conditions such as aids. the diagnosis is based on repeated isolations of the same mycobacterium associated with c ... | 2015 | 26344005 |
| rapid prediction of inducible clarithromycin resistance in mycobacterium abscessus. | we have developed a single tube taqman(®) real-time pcr assay that differentiates the full-length and truncated erm(41) gene to predict inducible resistance to clarithromycin in mycobacterium abscessus. a study of 87 clinical isolates found this assay to be 90.8% concordant to conventional drug susceptibility testing results for the prediction of inducible clarithromycin drug resistance. | 2015 | 26334290 |
| molecular mechanisms of clarithromycin resistance in mycobacterium abscessus complex clinical isolates from venezuela. | in this study, 26 clinical isolates of mycobacterium abscessus complex strains were characterised using available identification algorithms for the three species (m. abscessus, m. massiliense and m. bolletii) and the genotypic characteristics of clarithromycin (clr) resistance were determined. strains were identified by pcr restriction fragment length polymorphism analysis of the hsp65 and erm(41) gene sequences. susceptibility to clr was determined by the broth microdilution method. the mechani ... | 2015 | 27873710 |
| susceptibility of mycobacterium abscessus to antimycobacterial drugs in preclinical models. | over the last 10 years, mycobacterium abscessus group strains have emerged as important human pathogens, which are associated with significantly higher fatality rates than any other rapidly growing mycobacteria. these opportunistic pathogens are widespread in the environment and can cause a wide range of clinical diseases, including skin, soft tissue, central nervous system, and disseminated infections; by far, the most difficult to treat is the pulmonary form. infections with m. abscessus are o ... | 2015 | 26303795 |
| mycobacterium abscessus complex infections in humans. | mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. m. abscessus complex is differentiated into 3 subspecies: m. abscessus subsp. abscessus, m. abscessus subsp. massiliense, and m. abscessus subsp. bolletii. the 2 major subspecies, m. abscessus subsp. abscessus and m. abscessus ... | 2015 | 26295364 |
| clonal diversification and changes in lipid traits and colony morphology in mycobacterium abscessus clinical isolates. | the smooth-to-rough colony morphology shift in mycobacterium abscessus has been implicated in loss of glycopeptidolipid (gpl), increased pathogenicity, and clinical decline in cystic fibrosis (cf) patients. however, the evolutionary phenotypic and genetic changes remain obscure. serial isolates from nine non-cf patients with persistent m. abscessus infection were characterized by colony morphology, lipid profile via thin-layer chromatography and matrix-assisted laser desorption ionization-time o ... | 2015 | 26292297 |
| new real-time pcr assays for detection of inducible and acquired clarithromycin resistance in the mycobacterium abscessus group. | members of the mycobacterium abscessus group (mag) cause lung, soft tissue, and disseminated infections. the oral macrolides clarithromycin and azithromycin are commonly used for treatment. mag can display clarithromycin resistance through the inducible erm(41) gene or via acquired mutations in the rrl (23s rrna) gene. strains harboring a truncation or a t28c substitution in erm(41) lose the inducible resistance trait. phenotypic detection of clarithromycin resistance requires extended incubatio ... | 2015 | 26269619 |
| carbapenems and rifampin exhibit synergy against mycobacterium tuberculosis and mycobacterium abscessus. | an effective regimen for treatment of tuberculosis (tb) is comprised of multiple drugs that inhibit a range of essential cellular activities in mycobacterium tuberculosis. the effectiveness of a regimen is further enhanced if constituent drugs act with synergy. here, we report that faropenem (a penem) or biapenem, doripenem, or meropenem (carbapenems), which belong to the β-lactam class of antibiotics, and rifampin, one of the drugs that forms the backbone of tb treatment, act with synergy when ... | 2015 | 26259792 |
| separation of mycobacterium abscessus into subspecies or genotype level by direct application of peptide nucleic acid multi-probe- real-time pcr method into sputa samples. | recently, we introduced a novel peptide nucleic acid (pna) multi-probe real time pcr method targeting the hsp65 gene (hsp65 pna rt-pcr) to distinguish mycobacterium abscessus groups. | 2015 | 26259717 |
| two episodes of cutaneous non-tuberculous mycobacterial infection in a patient with psoriasis. | non-tuberculous mycobacteria (ntm) are a group of environmental pathogens, which cause a broad spectrum of disease. the incidence of ntm infection is increasing, especially in immunocompromized patients. the past three decades also saw a rapid increase in the incidence of ntm infection involving otherwise healthy subjects. we report a case of cutaneous ntm infection in a 79-year-old chinese woman, who was receiving methotrexate for psoriasis. mycobacterial culture grew mycobacterium abscessus, a ... | 2015 | 26236445 |
| pulmonary disease due to nontuberculous mycobacteria: current state and new insights. | since pulmonary nontuberculous mycobacteria (pntm) lung disease was last reviewed in chest in 2008, new information has emerged spanning multiple domains, including epidemiology, transmission and pathogenesis, clinical presentation, diagnosis, and treatment. the overall prevalence of pntm is increasing, and in the united states, areas of highest prevalence are clustered in distinct geographic locations with common environmental and socioeconomic factors. although the accepted paradigm for transm ... | 2015 | 26225805 |
| chest imaging comparison between non-tuberculous and tuberculosis mycobacteria in sputum acid fast bacilli smear-positive patients. | the aim of this study was to distinguish and compare the chest imaging features of non-tuberculous mycobacteria lung disease (ntm-ld) and pulmonary tuberculosis (ptb) in patients with sputum acid fast bacillus (afb)-smear positive since an earlier differential diagnosis between these two is very important in clinical practice. | 2015 | 26214779 |
| combating highly resistant emerging pathogen mycobacterium abscessus and mycobacterium tuberculosis with novel salicylanilide esters and carbamates. | in the mycobacterium genus over one hundred species are already described and new ones are periodically reported. species that form colonies in a week are classified as rapid growers, those requiring longer periods (up to three months) are the mostly pathogenic slow growers. more recently, new emerging species have been identified to lengthen the list, all rapid growers. of these, mycobacterium abscessus is also an intracellular pathogen and it is the most chemotherapy-resistant rapid-growing my ... | 2015 | 26210507 |
| susceptibility testing of mycobacterium abscessus by isothermal microcalorimetry. | we evaluated a new method for susceptibility testing of a rapidly growing mycobacterium using real-time measurement of heat (microcalorimetry). mics of 2 clinical mycobacterium abscessus isolates were determined by microbroth dilution and e-test. for microcalorimetry, middlebrook-7h10 agar+10% oleic acid-albumin-dextrose-catalase, containing amikacin, clarithromycin, linezolid, and ciprofloxacin was inoculated with ~10(5)cfu/ml. heat production was measured at 37°c for 72h. minimal heat inhibiti ... | 2015 | 26210204 |
| subinhibitory doses of aminoglycoside antibiotics induce changes in the phenotype of mycobacterium abscessus. | subinhibitory doses of antibiotics have been shown to cause changes in bacterial morphology, adherence ability, and resistance to antibiotics. in this study, the effects of subinhibitory doses of aminoglycoside antibiotics on mycobacterium abscessus were investigated. the treatment of m. abscessus cells with subinhibitory doses of amikacin was found to change their colony from a smooth to a rough morphotype and increase their ability to adhere to a polyvinylchloride plate, aggregate in culture, ... | 2015 | 26195529 |
| support from phylogenomic networks and subspecies signatures for separation of mycobacterium massiliense from mycobacterium bolletii. | mycobacterium abscessus subspecies classification has important clinical implications. we used phylogenomic network and amino acid analyses to provide evidence for the separation of mycobacterium bolletii and mycobacterium massiliense into two distinct subspecies which can potentially be differentiated rapidly by their protein signatures. | 2015 | 26157149 |
| otomastoiditis caused by non-tuberculous mycobacteria: report of 16 cases, 3 with infection intracranially. | to analyse the clinical presentation, treatment and outcome in patients diagnosed with otomastoiditis caused by non-tuberculous mycobacteria. | 2015 | 26153833 |
| hydrolysis of clavulanate by mycobacterium tuberculosis β-lactamase blac harboring a canonical sdn motif. | combinations of β-lactams with clavulanate are currently being investigated for tuberculosis treatment. since mycobacterium tuberculosis produces a broad spectrum β-lactamase, blac, the success of this approach could be compromised by the emergence of clavulanate-resistant variants, as observed for inhibitor-resistant tem variants in enterobacteria. previous analyses based on site-directed mutagenesis of blac have led to the conclusion that this risk was limited. here, we used a different approa ... | 2015 | 26149997 |
| infections caused by rapidly growing mycobacteria spp in children and adolescents with cancer. | rapidly growing mycobacteria (rgm) infections in pediatric oncology patients have not been completely characterized. | 2015 | 26407409 |
| epidemiology of nontuberculous mycobacteria in french polynesia. | as few data are available in the pacific countries and territories of the oceania region regarding nontuberculous mycobacteria,we retrospectively identified 87 such isolates from french polynesia from 2008 to 2013 by hybridization using dna-strip, matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) and partial rpob gene sequencing. partial rpob gene sequencing classified 42/87 (48.3%) isolates in the mycobacterium fortuitum complex, 28 (32.2%) in the mycob ... | 2015 | 26400787 |
| a novel cluster of mycobacterium abscessus complex revealed by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (maldi-tof ms). | mycobacterium abscessus complex is a rapidly growing mycobacterium consisting of 3 subspecies, m. abscessus, mycobacterium massiliense, and mycobacterium bolletii. however, rapid and accurate species identification is difficult. we first evaluated a suitable protocol of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (maldi-tof ms) for distinguishing these subspecies. then, we studied spectral signals by maldi-tof ms in 59 m. abscessus, 42 m. massiliense, and 2 m. bo ... | 2015 | 26388548 |
| deciphering and imaging pathogenesis and cording of mycobacterium abscessus in zebrafish embryos. | zebrafish (danio rerio) embryos are increasingly used as an infection model to study the function of the vertebrate innate immune system in host-pathogen interactions. the ease of obtaining large numbers of embryos, their accessibility due to external development, their optical transparency as well as the availability of a wide panoply of genetic/immunological tools and transgenic reporter line collections, contribute to the versatility of this model. in this respect, the present manuscript desc ... | 2015 | 26382225 |
| mycobacterium saopaulense sp. nov., a rapidly growing mycobacterium closely related to members of the mycobacterium chelonae--mycobacterium abscessus group. | five isolates of non-pigmented, rapidly growing mycobacteria were isolated from three patients and,in an earlier study, from zebrafish. phenotypic and molecular tests confirmed that these isolates belong to the mycobacterium chelonae-mycobacterium abscessus group, but they could not be confidently assigned to any known species of this group. phenotypic analysis and biochemical tests were not helpful for distinguishing these isolates from other members of the m. chelonae–m.abscessus group. the is ... | 2015 | 26358475 |
| nontuberculous mycobacteria: skin and soft tissue infections. | skin and soft tissue infections caused by nontuberculous mycobacteria are increasing in incidence. the nontuberculous mycobacteria are environmental, acid-fast bacilli that cause cutaneous infections primarily after trauma, surgery and cosmetic procedures. skin findings include abscesses, sporotrichoid nodules or ulcers, but also less distinctive signs. important species include mycobacterium marinum and the rapidly growing mycobacterium: m. fortuitum, m. abscessus and m. chelonae. obtaining tis ... | 2015 | 26143432 |
| inhaled antibiotics for refractory nontuberculous mycobacteria and non-cystic fibrosis bronchiectasis and the significance of mycobacterium abscessus subsp. abscessus isolation during m. avium complex lung disease therapy. | 2015 | 26131990 | |
| iatrogenic mycobacterium abscessus infection in a trigger finger. | an immunocompetent 63-year-old lady developed mycobacterium abscessus soft tissue infection of the hand following local corticosteroid injection for trigger finger. the patient was successfully treated with repeated radical debridement and prolonged antimicrobial therapy. atypical mycobacterial infections, including those caused by m. abscessus, albeit rare, should be considered in cases of late-onset indolent infection following local injury surgical procedures, and injections. clinical vigilan ... | 2015 | 26117482 |
| ifitms from mycobacteria confer resistance to influenza virus when expressed in human cells. | interferon induced transmembrane proteins (ifitms) found in vertebrates restrict infections by specific viruses. ifitm3 is known to be essential for restriction of influenza virus infections in both mice and humans. vertebrate ifitms are hypothesized to have derived from a horizontal gene transfer from bacteria to a primitive unicellular eukaryote. since bacterial ifitms share minimal amino acid identity with human ifitm3, we hypothesized that examination of bacterial ifitms in human cells would ... | 2015 | 26075508 |
| disseminated mycobacterium abscessus infection following septic arthritis: a case report and review of the literature. | mycobacterium abscessus is a rapidly growing mycobacterium found mainly in patients with respiratory or cutaneous infections, but it rarely causes disseminated infections. little is known about the clinical characteristics, treatment, and prognosis of disseminated m abscessus infection. a 75-year-old japanese woman who had been treated for 17 years with a corticosteroid for antisynthetase syndrome with antithreonyl-trna synthetase antibody developed swelling of her right elbow. x-ray of her righ ... | 2015 | 26020393 |
| [soft-tissue infection with mycobacterium abscessus subsp. abscessus after liposuction and panniculectomy in the caribbean]. | we report the case of a 36-year-old woman who presented with a surgical site infection with atypical mycobacteria several months after liposuction in the caribbean. postoperative wound infections with mycobacterium abscessus present as subcutaneous nodular abscesses with partly putrid secretion. due to the necessity of specific diagnostic measures, diagnosis is often delayed. treatment is difficult because mycobacterium abscessus is resistant to conventional tuberculostatics and many other antib ... | 2015 | 26016828 |
| peritoneal dialysis-associated peritonitis caused by mycobacterium abscessus. | 2015 | 26015424 | |
| mycobacterium abscessus abscess post-thread facial rejuvenation procedure. | 2015 | 25987942 | |
| mycobacterium abscessus pulmonary infection under treatment with tocilizumab. | although biological agents are of considerable benefit to patients with rheumatoid arthritis (ra), the potential for opportunistic infections is a critical issue. it is therefore important to achieve a balance between treatment efficacy and controlling opportunistic infection. we herein report the successfully managed case of a 53-year-old patient with ra who developed pulmonary mycobacterium abscessus infection during treatment with tocilizumab and methotrexate. | 2015 | 25986276 |
| identification of mycobacterium abscessus complex and m. abscessus subsp. massiliense culture isolates by real-time assays. | 2015 | 25976000 | |
| evaluation of the efficacy of novel oxazolidinone analogues against nontuberculous mycobacteria in vitro. | nontuberculous mycobacteria (ntm) are associated with a number of clinical diseases and only a few antitubercular agents are active against them. oxazolidinones comprise a novel class of antimicrobials that inhibit bacterial protein synthesis at the ribosome. linezolid, the first oxazolidinone antibacterial agent approved for clinical use, has excellent activity against some ntm but is ineffective against others. sy142 and sy144 are novel oxazolidinones with demonstrated activties against mycoba ... | 2015 | 25971324 |
| rapid diagnosis of mycobacterium abscessus hand infection by oligonucleotide array in an immunocompetent patient. | 2015 | 25959575 | |
| serodiagnosis of mycobacterium abscessus complex infection in cystic fibrosis. | early signs of pulmonary disease with mycobacterium abscessus complex (mabsc) can be missed in patients with cystic fibrosis (cf). a serological method could help stratify patients according to risk. the objective of this study was to test the diagnostic accuracy of a novel method for investigating igg activity against mabsc.a prospective study of all patients attending the copenhagen cf centre was conducted by culturing for mabsc during a 22-month period and then screening patients with an anti ... | 2015 | 25929948 |
| rapid detection of acquired and inducible clarithromycin resistance in mycobacterium abscessus group by a simple real-time pcr assay. | by targeting the erm(41) and rrl genes in the mycobacterium abscessus group, a multiplex real-time pcr assay for clarithromycin resistance showed 95% (38/40) concordance with nucleic acid testing and 95% (37/39) concordance with phenotypic testing. this assay provides a simple and rapid alternative to extended incubation or erm(41) sequencing. | 2015 | 25903572 |
| increased frequency of nontuberculous mycobacteria detection at potable water taps within the united states. | nontuberculous mycobacteria (ntms) are environmental microorganisms that can cause infections in humans, primarily in the lung and soft tissue. the prevalence of ntm-associated diseases is increasing in the united states. exposure to ntms occurs primarily through human interactions with water (especially aerosolized). potable water from sites across the u.s. was collected to investigate the presence of ntm. water from 68 taps was sampled 4 times over the course of 2 years. in total, 272 water sa ... | 2015 | 25902261 |
| multisite infection with mycobacterium abscessus after replacement of breast implants and gluteal lipofilling. | introduction. medical tourism for aesthetic surgery is popular. nontuberculous mycobacteria (ntm) occasionally cause surgical-site infections. as ntm grow in biofilms, implantations of foreign bodies are at risk. due to late manifestation, infections occur when patients are back home, where they must be managed properly. case report. a 39-year-old healthy female was referred for acute infection of the right gluteal area. five months before, she had breast implants replacement, abdominal liposuct ... | 2015 | 25893122 |
| mycobacterium franklinii sp. nov., a species closely related to members of the mycobacterium chelonae-mycobacterium abscessus group. | two isolates from water, d16q19 and d16r27, were shown to be highly similar in their 16s rrna, 16s-23s internal transcribed spacer (its), hsp65 and rpob gene sequences to 'mycobacterium franklinii' dsm 45524, described in 2011 but with the name not validly published. they are all nonpigmented rapid growers and are related phenotypically and genetically to the mycobacterium chelonae-mycobacterium abscessus group. extensive characterization by phenotypic analysis, biochemical tests, drug susceptib ... | 2015 | 25858242 |
| pediatric cutaneous nontuberculous mycobacterium infections in singapore. | nontuberculous mycobacterium (ntm) infections are rare in children, with limited published studies. the course of the disease can be variable and there are no accepted treatment guidelines for the management of ntm infections in children. | 2015 | 25845296 |
| nontuberculous mycobacteria in cystic fibrosis and non-cystic fibrosis bronchiectasis. | increasing numbers of cystic fibrosis (cf) and non-cf bronchiectasis patients are affected by pulmonary nontuberculous mycobacteria (ntm) infection worldwide. two species of ntm account for up to 95% of the pulmonary ntm infections: mycobacterium avium complex (mac) and mycobacterium abscessus complex (mabsc). diagnosis of pulmonary ntm infection is based on criteria specified in the 2007 american thoracic society/infectious disease society of america (ats/idsa) guidelines. while many initial po ... | 2015 | 25826589 |
| mycobacterium abscessus pulmonary infection complicated with vertebral osteomyelitis in a heart transplant recipient: case report and literature review. | infections produced by mycobacterium abscessus are emerging in immunosuppressed patients, such as solid organ transplant recipients. we report the first case, to our knowledge, of a vertebral osteomyelitis caused by m. abscessus in a heart transplant recipient, and review the risk factors, manifestations, and therapeutic approaches to this uncommon disease. | 2015 | 25816889 |
| cutaneous infections caused by rapidly growing mycobacteria: case reports and review of clinical and laboratory aspects. | skin and soft tissue infections caused by rapidly growing non-tuberculous mycobacteria (rg-ntm) have become a growing clinical concern over the past decades. these rg-ntm are ubiquitous environmental organisms and most are resistant to traditional antituberculous agents. in this report, we describe 3 cutaneous infections caused by rg-ntm, namely, mycobacterium abscessus, m. chelonae, and m. conceptionense, and present the clinical and laboratory characteristics of these infections. | 2015 | 25809023 |
| bacterial phospholipases c as vaccine candidate antigens against cystic fibrosis respiratory pathogens: the mycobacterium abscessus model. | vaccine strategies represent one of the fighting answers against multiresistant bacteria in a number of clinical settings like cystic fibrosis (cf). mycobacterium abscessus, an emerging cf pathogen, raises difficult therapeutic problems due to its intrinsic antibiotic multiresistance. | 2015 | 25804706 |
| molecular epidemiology of mycobacterium abscessus complex isolates in ireland. | the mycobacterium abscessus complex are the rapidly growing mycobacteria (rgm) most commonly causing lung disease, especially in cystic fibrosis (cf) patients. ireland has the world's highest cf incidence. the molecular epidemiology of m. abscessus complex in ireland is unreported. | 2016 | 26072272 |
| postcesarean section wound infection caused by mycobacterium massiliense. | mycobacterium abscessus subsp. massiliense (a subspecies of the m. abscessus complex) is a rare causative agent of surgical site infection after cesarean section (c section). we tried to seek the common source of infection and unravel the optimal treatment modalities. | 2016 | 26350122 |
| mycobacterium abscessus ventriculoperitoneal shunt infection and review of the literature. | a 30-year-old man with history of neonatal hydrocephalus requiring ventriculoperitoneal shunt placement presented with mycobacterium abscessus shunt infection despite no shunt manipulation over 10 years prior to presentation. cure was not achieved until complete removal of all cns shunt foreign body was performed despite initial adequate antimicrobial therapy. | 2016 | 26148928 |
| synthesis and biological activity of alkynoic acids derivatives against mycobacteria. | 2-alkynoic acids have bactericidal activity against mycobacterium smegmatis but their activity fall sharply as the length of the carbon chain increased. in this study, derivatives of 2-alkynoic acids were synthesized and tested against fast- and slow-growing mycobacteria. their activity was first evaluated in m. smegmatis against their parental 2-alkynoic acids, as well as isoniazid, a first-line antituberculosis drug. the introduction of additional unsaturation or heteroatoms into the carbon ch ... | 2016 | 26256431 |
| [pulmonary mycobacterium abscessus sensu lato infection in patients without cystic fibrosis]. | infection with mycobacterium abscessus sensu lato is uncommon in patients without cystic fibrosis. we are interested in these patients and have collected cases in finistère between 2007 and 2011. | 2016 | 26238926 |
| in vitro antimicrobial susceptibility of nontuberculous mycobacteria in iran. | many species of nontuberculous mycobacteria (ntm) have long been identified as important causes of human disease, the incidence of which is rising. several reports have suggested increasing trend of both in vitro and in vivo resistance to available treatment regimes. the aim of this study was to evaluate antibiotic susceptibility of clinically relevant ntm isolates using standard microbroth dilution test. antimicrobial susceptibility testing was performed following national committee for clinica ... | 2016 | 26468990 |
| infection control strategies that successfully controlled an outbreak of mycobacterium abscessus at a cystic fibrosis center. | mycobacterium abscessus infection in patients with cystic fibrosis (cf) can result in accelerated clinical decline and the potential for direct or indirect transmission between patients has been recently demonstrated. data on the outcomes of m abscessus outbreaks and the efficacy of specific infection control procedures in patients with cf remain limited. this study provides follow-up from an outbreak of pulmonary m abscessus in our center, highlighting outcomes and strategies that appear to hav ... | 2016 | 26442462 |
| source investigation of two outbreaks of skin and soft tissue infection by mycobacterium abscessus subsp. abscessus in venezuela. | outbreaks of soft tissue or skin infection due to non-tuberculous mycobacteria are reported frequently in scientific journals but in general the infection source in these outbreaks remains unknown. in venezuela, in two distinct outbreaks, one after breast augmentation surgery and another after hydrolipoclasy therapy, 16 patients contracted a soft tissue infection due to mycobacterium abscessus subsp. abscessus. searching for the possible environmental infection sources in these outbreaks, initia ... | 2016 | 26441024 |
| improvement in quality of life after therapy for mycobacterium abscessus group lung infection. a prospective cohort study. | mycobacterium abscessus group lung infection is characterized by low cure rates. improvement in quality of life may be a reasonable treatment goal. | 2016 | 26540302 |
| nontuberculous mycobacterial infection with concurrent igg4-related lymphadenopathy. | disseminated nontuberculous mycobacteria (ntm) infection with concurrent igg4-related lymphadenopathy has not been reported. we described a patient with neutralizing autoantibodies to interferon-gamma (ifn-γ) and elevated levels of serum igg4 presenting with generalized lymphadenopathy and reactive dermatosis. histologically, lymph nodes (lns) showed effaced nodal architecture with polymorphic infiltrates, mimicking angioimmunoblastic t-cell lymphoma. both the absolute number and the ratio of ig ... | 2016 | 26660641 |
| clofazimine prevents the regrowth of mycobacterium abscessus and mycobacterium avium type strains exposed to amikacin and clarithromycin. | multidrug therapy is a standard practice when treating infections by nontuberculous mycobacteria (ntm), but few treatment options exist. we conducted this study to define the drug-drug interaction between clofazimine and both amikacin and clarithromycin and its contribution to ntm treatment. mycobacterium abscessus and mycobacterium avium type strains were used. time-kill assays for clofazimine alone and combined with amikacin or clarithromycin were performed at concentrations of 0.25× to 2× mic ... | 2016 | 26643335 |
| elevated serum ca 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease. | increased serum ca 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. this study evaluates the clinical significance of serum ca 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. the median ca 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p<0.001). a m ... | 2016 | 26613892 |
| multilocus enzyme electrophoresis analysis of rapidly-growing mycobacteria: an alternative tool for identification and typing. | rapidly growing mycobacteria (rgm) have emerged as important pathogens in clinical settings, associated with esthetic procedures and postsurgical infections, pulmonary infections among cystic fibrosis patients, and other structural pulmonary diseases. microorganisms belonging to mycobacterium abscessus-mycobacterium chelonae and to mycobacterium fortuitum groups have frequently been associated with outbreaks and various epidemics. in the present study, rgm strains were characterized in order to ... | 2016 | 26603643 |
| utility of the maldi-tof ms method to identify nontuberculous mycobacteria. | in comparison to the conventional real-time polymerase chain reaction method (pcr method) or the dna-dna hybridization method (ddh method), the utility of ntm identification by the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) method has seldom been reported. in this study, 75 clinical ntm isolates from our hospital between april 2013 and july 2014 were identified and analyzed using pcr, ddh, and maldi-tof ms methods, and the results for the maldi-to ... | 2016 | 26603481 |
| safety of iv amikacin in the treatment of pulmonary non-tuberculous mycobacterial disease. | pulmonary non-tuberculous mycobacterial (ntm) disease has a high mortality rate and often requires treatment with intravenous amikacin. we report on safety data in patients treated with intravenous amikacin for pulmonary. | 2016 | 26581837 |
| subspecies distribution and macrolide and fluoroquinolone resistance genetics of mycobacterium abscessus in korea. | treating mycobacterium abscessus infections with antimicrobials remains difficult, possibly due to drug resistance. | 2016 | 26688536 |
| disseminated talaromyces marneffei and mycobacterium abscessus in a patient with anti-interferon-γ autoantibodies. | anti-interferon (ifn)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. we report on disseminated talaromyces (penicillium) marneffei and mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, thai man with anti-ifn-γ autoantibody. the patient was successfully treated with antimicrobial therapy and rituximab to control b cell-derived autoantibodies. | 2016 | 27419165 |
| complete genome sequence of a novel clinical isolate, mycobacterium abscessus strain nov0213. | mycobacterium abscessus is a rapid-growing species of nontuberculous mycobacteria that is frequently associated with opportunistic infections in humans. we determined the complete genome sequence of the m. abscessus strain nov0213, which was isolated from a patient with tuberculosis-like disease and with various antibiotic resistances. | 2016 | 26744369 |
| deficient interleukin-17 production in response to mycobacterium abscessus in cystic fibrosis. | 2016 | 26743483 | |
| mycobacterium abscessus complex - a particular challenge in the setting of lung transplantation. | mycobacterium abscessus complex is an emerging pathogen in lung transplant candidates and recipients. m. abscessus complex is widespread in the environment and can cause pulmonary, skin and soft tissue, and disseminated infection, particularly in lung transplant recipients. it is innately resistant to many antibiotics making it difficult to treat. herein we describe the epidemiology, clinical manifestations, diagnosis and treatment of m. abscessus with an emphasis on lung transplant candidates a ... | 2016 | 26732819 |
| biofilm formation by mycobacterium abscessus in a lung cavity. | 2016 | 26731090 | |
| the antimicrobial susceptibility of non-tuberculous mycobacteria. | pulmonary non-tuberculous mycobacterial infection (ntm) is a challenging and increasingly prevalent infection. antimicrobial resistance is common and may be associated with poor outcomes. this retrospective study aimed to report longitudinal trends in mycobacterial isolation and ntm drug susceptibility. | 2016 | 26723913 |
| analytical and clinical evaluation of the epistem genedrive assay for detection of mycobacterium tuberculosis. | the epistem genedrive assay rapidly detects the mycobacterium tuberculosis omplex from sputum and is currently available for clinical use. however, the analytical and clinical performance of this test has not been fully evaluated. the analytical limit of detection (lod) of the genedrive pcr amplification was tested with genomic dna; the performance of the complete (sample processing plus amplification) system was tested by spiking m. tuberculosismc(2)6030 cells into distilled water andm. tubercu ... | 2016 | 26865685 |
| nontuberculous mycobacterial infections in cystic fibrosis. | nontuberculous mycobacteria (ntm) are important emerging cystic fibrosis (cf) pathogens, with estimates of prevalence ranging from 6% to 13%. diagnosis of ntm disease in patients with cf is challenging, as the infection may remain indolent in some, without evidence of clinical consequence, whereas other patients suffer significant morbidity and mortality. treatment requires prolonged periods of multiple drugs and varies depending on ntm species, resistance pattern, and extent of disease. the dev ... | 2016 | 26857770 |
| management of mycobacterium abscessus infection after medical tourism in cosmetic surgery and a review of literature. | despite news reports, food and drug administration disclaimers, and warnings from us plastic surgeons against the perils of cosmetic tourism, patients continue to seek care abroad and often present with infectious complications. recent reports of mycobacterium abscessus surgical site infection (ssi) is of particularly concern and its management, particularly surgical intervention, has been poorly documented. | 2016 | 26835829 |
| a chlorhexidine- agar plate culture medium protocol to complement standard broth culture of mycobacterium tuberculosis. | the culture of mycobacterium tuberculosis using parallel inoculation of a solid culture medium and a liquid broth provides the gold standard for the diagnosis of tuberculosis. here, we evaluated a chlorhexidine decontamination-mod9 solid medium protocol versus the standard nalc-naoh-bactec 960 mgit protocol for the diagnosis of pulmonary tuberculosis by culture. three-hundred clinical specimens comprising 193 sputa, 30 bronchial aspirates, 10 broncho-alveolar lavages, 47 stools, and 20 urines we ... | 2016 | 26834733 |
| characterization of mycobacterium abscessus subtypes in shanghai of china: drug sensitivity and bacterial epidemicity as well as clinical manifestations. | the aim of the study was to investigate the epidemic characteristics of mycobacterium abscessus in shanghai.fifty-five strains from 55 m. abscessus pulmonary disease patients were isolated. drug sensitivity was measured by a broth microdilution method. subtypes of m. abscessus were identified by dna sequencing. multilocus sequence typing (mlst), mining spanning tree (mst), and pulsed-field gel electrophoresis (pfge) were used to analyze sequence types (st) and clonal complexes (cc). clinical man ... | 2016 | 26817866 |
| prolonged postprocedural outbreak of mycobacterium massiliense infections associated with ultrasound transmission gel. | postprocedural infections by mycobacterium abscessus complex are increasing worldwide, and the source and route of transmission are infrequently identified. here the extension of a previous clustering of paediatric patients with surgical site infections due to a single strain of the subspecies m. massiliense is reported. the investigation was conducted at a 2200-bed teaching hospital in taiwan and included microbial surveillance of the environment (water, air, equipment and supplies) and a case- ... | 2016 | 26794030 |
| identification of antimicrobial activity among new sulfonamide metal complexes for combating rapidly growing mycobacteria. | mycobacteriosis is a type of infection caused by rapidly growing mycobacteria (rgm), which can vary from localized illness, such as skin disease, to disseminated disease. amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem and sulfamethoxazole are antimicrobial drugs chosen to treat such illnesses; however, not all patients obtain the cure. the reason why the treatment does not work for those patients is related to the fact that some clinical strains present resistance to t ... | 2016 | 27567903 |
| antibiofilm effect of antimicrobials used in the therapy of mycobacteriosis. | rapidly growing mycobacteria (rgm) are opportunistic pathogens found in the environment. when in biofilms, mycobacteria is highly resistant to antibacterial treatments. the purpose of this study is to evaluate the antibiofilm activity of antimicrobials commonly used in therapy against mycobacteria. the antimicrobial susceptibility of mycobacterium abscessus, mycobacterium fortuitum and mycobacterium massiliense was determined in planktonic and sessile populations. the antimicrobials amikacin, ci ... | 2016 | 27554273 |
| mycobacterium abscessus scleritis after a baerveldt glaucoma implant. | 2016 | 27552708 | |
| [mycobacterium abscessus pulmonary disease: important pathogen involved in microbial substitution during the treatment of non-abscessus mycobacterial disease]. | mycobacterium abscessus pulmonary disease is common in patients with bronchiectasis. however, the underlying disease that is more likely to be present in patients with m. abscessus pulmonary disease remains poorly understood. | 2016 | 27530020 |
| cystic teratoma mimicking recurrent pleural effusion, complicated by mycobacterium abscessus infection. | teratomas of anterior mediastinum are rare. they are often slow growing, asymptomatic, and detected incidentally on chest imaging. mycobacterium abscessus (m. abscessus) is an acid-fast bacillus that is classified as a pathogenic "rapid growing" non-tuberculous mycobacteria. it is an uncommon cause of human pathology, which may cause skin and soft tissue infection after skin injury following inoculation, minor trauma, and surgery. here, we present an unusual case of benign cystic teratoma mimick ... | 2016 | 27516884 |
| non-tuberculous mycobacteria: classification, diagnostics, and therapy. | non-tuberculous mycobacteria (ntm) are species other than those belonging to the mycobacterium tuberculosis complex and do not cause leprosy. ntm are generally free-living organisms that are ubiquitous in the environment. there have been more than 140 ntm species identified to-date. they can cause a wide range of infections, with pulmonary infections being the most frequent (65-90 %). there is growing evidence that the incidence of ntm lung diseases and associated hospitalizations are on the ris ... | 2016 | 27401079 |
| deletion of a dehydratase important for intracellular growth and cording renders rough mycobacterium abscessus avirulent. | mycobacterium abscessus (mabs) is a rapidly growing mycobacterium and an emerging pathogen in humans. transitioning from a smooth (s) high-glycopeptidolipid (gpl) producer to a rough (r) low-gpl producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, abscesses, and rapid larval death. generating a cord-deficient mabs mutant would allow us to address the contribution of cording in the physiopathological signs of the r variant. herein ... | 2016 | 27385830 |
| the impact of protein extraction protocols on the performance of currently available maldi-tof mass spectrometry for identification of mycobacterial clinical isolates cultured in liquid media. | protein extraction step is particularly important for identification of mycobacterial isolates by maldi-tof mass spectrometry (ms) because of its thick and solid cell wall. this study compared the performance of maldi-tof ms for identification of mycobacterial clinical isolates cultured in liquid media between heating-based protocol and non-heating protocol. | 2016 | 27380997 |
| disseminated mycobacterium abscessus complex infection manifesting as multiple areas of lymphadenitis and skin abscess in the preclinical stage of acute lymphocytic leukemia. | a 37-year-old woman was admitted to a hospital due to a prolonged fever and a rash on her legs. she had systemic lymphadenitis and a skin abscess on her left leg. pathological findings of a left leg skin biopsy revealed abscess formation with granulomatous dermatitis, mycobacterium abscessus complex was cultured from the resected left supraclavicular lymph node, and disseminated m. abscessus complex infection was diagnosed. she was treated with combination treatment with antimicrobials and percu ... | 2016 | 27374685 |
| analysis of pulmonary non-tuberculous mycobacterial infections after lung transplantation. | non-tuberculous mycobacteria (ntm) are important pathogens in lung transplant recipients. this study describes the spectrum of ntm respiratory tract infections and examines the association of ntm infections with lung transplant complications. | 2016 | 27368989 |
| medical management for the treatment of nontuberculous mycobacteria infection of the parotid gland: avoiding surgery may be possible. | infection with nontuberculous mycobacteria (ntm) is uncommon in the head and neck; therefore there is no clear consensus on treating these infections. our objective was to report our experience with a unique case of ntm infection of the parotid in an immunocompetent patient, in order to determine appropriate management through our experience with this pathology. a 57-year-old man, known for numerous comorbid diseases, presented to our institution complaining of right parotid swelling and pain. a ... | 2016 | 27340407 |
| identification of lysine acetylation in mycobacterium abscessus using lc-ms/ms after immunoprecipitation. | mycobacterium abscessus (mab), which manifests in the pulmonary system, is one of the neglected causes of nontuberculous mycobacteria (ntm) infection. treatment against mab is difficult, characterized by its intrinsic antibiotic drug resistance. lysine acetylation can alter the physiochemical property of proteins in living organisms. this study aimed to determine if this protein post-translational modification (ptm) exists in a clinical isolate m. abscessus gz002. we used the antiacetyl-lysine i ... | 2016 | 27323652 |