Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| isolation and characterization of nontuberculous mycobacteria from patients with pulmonary tuberculosis in ghana. | nontuberculous mycobacterial (ntm) species are assuming public health importance in pulmonary diseases; they are increasingly being isolated, and importantly, most ntms do not respond to routine tuberculosis (tb) drugs. this study aimed to identify ntms isolated from pulmonary tb cases and also determine their susceptibility to streptomycin (str), isoniazid (inh), and rifampicin (rif). | 2017 | 28317808 |
| port-site infections by nontuberculous mycobacterium: a retrospective clinico-microbiological study. | port-site infection (psi) is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (ls). it neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. psis are preventable with appropriate preoperative, intraoperative, and postoperative measures. atypical mycobacterium is most commonly associated with nonhealing postlaparoscopic wound infections, causing outbr ... | 2017 | 28317802 |
| mycobacterium abscessus subsp. abscessus is capable of degrading pseudomonas aeruginosa quinolone signals. | pseudomonas aeruginosa employs 2-heptyl-3-hydroxy-4(1h)-quinolone (the pseudomonas quinolone signal, pqs) and 2-heptyl-4(1h)-quinolone (hhq) as quorum sensing signal molecules, which contribute to a sophisticated regulatory network controlling the production of virulence factors and antimicrobials. we demonstrate that mycobacterium abscessus(t) and clinical m. abscessus isolates are capable of degrading these alkylquinolone signals. genome sequences of 50 clinical m. abscessus isolates indicated ... | 2017 | 28303132 |
| comparative genome analyses of mycobacteria give better insights into their evolution. | mycobacteria a genus of actinobacteria are widespread in nature ranging from soil-dwelling saprophytes to human and animal pathogens. the rate of growth has been a classifying factor for the mycobacterium spp., dividing them into the rapid growers and the slow growers. here we have performed a comparative genome study of mycobacterial species in order to get better understanding of their evolution, particularly to understand the distinction between the rapid and slow growers. our study shows tha ... | 2017 | 28291784 |
| granulomatous lobular mastitis associated with mycobacterium abscessus in south china: a case report and review of the literature. | mycobacteria, which are known as rapidly growing bacteria, are pathogens that are responsible for cutaneous or subcutaneous infections that especially occur after injection, trauma, or surgery. in this report, we describe a species of mycobacterium abscessus that was isolated from a breast abscess in a patient who was previously diagnosed with granulomatous lobular mastitis (glm). this current case is the first ever presented case of glm associated with m. abscessus documented in south china. th ... | 2017 | 28286681 |
| non-disulfide-bridge peptide 5.5 from the scorpion hadrurus gertschi inhibits the growth of mycobacterium abscessus subsp. massiliense. | multi-drug resistant microorganisms have been a growing concern during the last decades due to their contribution in mortality rates worldwide. antimicrobial peptides (amps) are broad spectrum antimicrobial agents that display potent microbicidal activity against a wide range of microorganisms. amps generally have a rapid mode of action that reduces the risk of resistance developing among pathogens. in this study, an amp derived from scorpion venom, ndbp-5.5, was evaluated against mycobacterium ... | 2017 | 28275372 |
| progression and treatment outcomes of lung disease caused by mycobacterium abscessus and mycobacterium massiliense. | mycobacterium abscessus and mycobacterium massiliense are grouped as the mycobacterium abscessus complex. the aim of this study was to elucidate the differences between m. abscessus and m. massiliense lung diseases in terms of progression rate, treatment outcome, and the predictors thereof. | 2017 | 28011609 |
| mycobacterial characteristics and treatment outcomes in mycobacterium abscessus lung disease. | treatment outcomes of patients with mycobacterium abscessus subspecies abscessus lung disease are poor, and the microbial characteristics associated with treatment outcomes have not been studied systematically. the purpose of this study was to identify associations between microbial characteristics and treatment outcomes in patients with m. abscessus lung disease. | 2017 | 28011608 |
| a clofazimine-containing regimen for the treatment of mycobacterium abscessus lung disease. | patients with lung disease caused by mycobacterium abscessus subspecies abscessus (hereafter m. abscessus) typically have poor treatment outcomes. although clofazimine (cfz) has been increasingly used in the treatment of m. abscessus lung disease in clinical practice, there are no published data on its effectiveness for this disease. this study sought to evaluate the clinical efficacy of a cfz-containing regimen for the treatment of m. abscessus lung disease. we performed a retrospective review ... | 2017 | 28348153 |
| atypical mycobacterial infections of the upper extremity: becoming more atypical? | background: atypical mycobacterial infections are uncommon and characterized by a chronic, indolent course before diagnosis. historically, these infections are associated with marine-related injury and/or immune dysfunction. our institution has successfully diagnosed and treated an increasing number of these infections. the objective of this study is to review our experience with these rare infections and verify the developing trends encountered. methods: a retrospective review was performed for ... | 2017 | 28344532 |
| selection of resistance to clarithromycin in mycobacterium abscessus subspecies. | mycobacterium abscessus is an emerging pathogen against which clarithromycin is the main drug used. clinical failures are commonly observed and were first attributed to acquired mutations in rrl encoding 23s rrna but were then attributed to the intrinsic production of the erm(41) 23s rna methylase. since strains of m. abscessus were recently distributed into subspecies and erm(41) sequevars, we investigated acquired clarithromycin resistance mechanisms in mutants selected in vitro from four repr ... | 2017 | 27799212 |
| a laboratory-based analysis of nontuberculous mycobacterial lung disease in japan from 2012 to 2013. | since 2010, mycobacterial examination results have been used widely to survey nontuberculous mycobacteria (ntm) lung disease. | 2017 | 27788025 |
| mycobacterium abscessus skin infection after tattooing--case report. | mycobacterium abscessus is a rapidly growing mycobacterium that has been affecting people undergoing invasive procedures, such as videosurgery and mesotherapy. this bacterium has global distribution, being found in numerous niches. the frequency of published reports of infection by rapidly growing mycobacteria associated with tattooing procedures has increased in recent years. however, in brazil there were no case reports of m. abscessus after tattooing in the literature until now. in this paper ... | 2017 | 26560222 |
| biochemical characterization of β-lactamases from mycobacterium abscessus complex and genetic environment of the β-lactamase-encoding gene. | the objectives of this study were to determine the kinetic parameters of purified recombinant blamab and blammas by spectrophotometry, analyze the genetic environment of the blamab and blammas genes in both species by polymerase chain reaction and sequencing, furthermore, in silico models of both enzymes in complex with imipenem were obtained by modeling tools. our results showed that blamab and blammas have a similar hydrolysis behavior, displaying high catalytic efficiencies toward penams, cep ... | 2017 | 27429159 |
| mycobacterium abscessus lung infection: a case report. | 2017 | 27403004 | |
| nontuberculous mycobacteria-overview. | nontuberculous mycobacteria (ntm) are emerging pathogens that affect both immunocompromised and immunocompetent patients. the development of molecular methods has allowed the characterization of new species and the identification of ntm to the precise species and subspecies levels. the incidence and prevalence of ntm lung disease are increasing worldwide, and this syndrome accounts for the majority of clinical cases of ntm disease. common causative organisms of pulmonary infection are the slowly ... | 2017 | 28128073 |
| notification of nontuberculous mycobacteria: an australian perspective. | in queensland, australia, all cases of mycobacterial infection (tuberculosis [tb] and nontuberculous mycobacteria [ntm]) are notifiable under the queensland public health act (2005). this process originally emerged to avoid ntm confounding with notification of cases of tb, but has facilitated awareness of the increasing incidence and changing epidemiology of ntm. although initially not a public health priority, the notification process has facilitated research that has led to an appreciation of ... | 2017 | 28118021 |
| resistance to thiacetazone derivatives active against mycobacterium abscessus involves mutations in the mmpl5 transcriptional repressor mab_4384. | available chemotherapeutic options are very limited against mycobacterium abscessus, which imparts a particular challenge in the treatment of cystic fibrosis (cf) patients infected with this rapidly growing mycobacterium. new drugs are urgently needed against this emerging pathogen, but the discovery of active chemotypes has not been performed intensively. interestingly, however, the repurposing of thiacetazone (tac), a drug once used to treat tuberculosis, has increased following the decipherin ... | 2017 | 28096157 |
| intrinsic rifamycin resistance of mycobacterium abscessus is mediated by adp-ribosyltransferase mab_0591. | rifampicin, a potent first-line tb drug of the rifamycin group, shows only little activity against the emerging pathogen mycobacterium abscessus. reportedly, bacterial resistance to rifampicin is associated with polymorphisms in the target gene rpob or the presence of enzymes that modify and thereby inactivate rifampicin. the aim of this study was to investigate the role of the mab_0591 (arrmab)-encoded rifampicin adp-ribosyltransferase (arr_mab) in innate high-level rifampicin resistance in m. ... | 2017 | 27999011 |
| evaluation of the antimicrobial activity of the mastoparan polybia-mpii isolated from venom of the social wasp pseudopolybia vespiceps testacea (vespidae, hymenoptera). | mastoparans, a class of peptides found in wasp venom, have significant effects following a sting as well as useful applications in clinical practice. among these is their potential use in the control of micro-organisms that cause infectious diseases with a significant impact on society. thus, the present study describes the isolation and identification of a mastoparan peptide from the venom of the social wasp pseudopolybia vespiceps and evaluated its antimicrobial profile against bacteria (staph ... | 2017 | 28108242 |
| inhibition of β-lactamases of mycobacteria by avibactam and clavulanate. | mycobacterium tuberculosis and mycobacterium abscessus produce broad-spectrum class a β-lactamases, blac and bla mab , which are inhibited by clavulanate and avibactam, respectively. blac differs from bla mab at ambler position 132 in the conserved motif sdn (sdg versus sdn, respectively). here, we investigated whether this polymorphism could account for the inhibition specificity of β-lactamases from slowly and rapidly growing mycobacteria. | 2017 | 28039278 |
| mixed infection of mycobacterium abscessus subsp. abscessus and mycobacterium tuberculosis in the lung. | a mixed infection of mycobacterium abscessus subsp. abscessus (mab) and mycobacterium tuberculosis (mtb) in the lung is an unusual clinical manifestation and has not yet been reported. a 61-year-old woman had been treated for mab lung disease and concomitant pneumonia, and was diagnosed with pulmonary tuberculosis (ptb). despite both anti-ptb and anti-mab therapy, her entire left lung was destroyed and collapsed. she underwent left pneumonectomy and received medical therapy. we were able to succ ... | 2017 | 28180105 |
| case report on pulmonary disease due to coinfection of mycobacterium tuberculosis and mycobacterium abscessus: difficulty in diagnosis. | mycobacterium abscessus, which is ubiquitous environmental organism, is more likely to cause pulmonary infection in the presence underlying lung disease and immunosuppression. we report a case of pulmonary disease due to coinfection of mycobacterium tuberculosis (mtb) and mycobacterium abscessus (m. abscessus) in an immunocompetent patient without underlying lung disease. healthcare professionals should be aware of co-infection with mtb and m. abscessus, and treatment should be based on clinical ... | 2017 | 28180066 |
| a case of mycobacterium abscessus subsp. massiliense lung disease complicated by lipoid pneumonia. | 2017 | 28157481 | |
| multidrug-resistant mycobacterium abscessus threatens patients with cystic fibrosis. | 2017 | 27956215 | |
| nontuberculous mycobacteria in children: a focus on bloodstream infections. | nontuberculous mycobacteria (ntm) are ubiquitous organisms with variable disease-causing potential. bloodstream infections caused by ntm in children are poorly described. | 2017 | 27918379 |
| inhibition of the β-lactamase blamab by avibactam improves the in vitro and in vivo efficacy of imipenem against mycobacterium abscessus. | mycobacterium abscessus pulmonary infections are treated with a macrolide (clarithromycin or azithromycin), an aminoglycoside (amikacin), and a β-lactam (cefoxitin or imipenem). the triple combination is used without any β-lactamase inhibitor, even though mabscessus produces the broad-spectrum β-lactamase blamab we determine whether inhibition of blamab by avibactam improves the activity of imipenem against m. abscessus the bactericidal activity of drug combinations was assayed in broth and in h ... | 2017 | 28096155 |
| two-phase hospital-associated outbreak of mycobacterium abscessus: investigation and mitigation. | nontuberculous mycobacteria (ntm) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. we investigated a biphasic outbreak of mycobacterium abscessus at a tertiary care hospital. | 2017 | 28077517 |
| biofilm colonization in chronic treatment refractory infections presenting with discharging sinuses: a study in a tertiary care hospital of eastern india. | treatment refractory chronic recurrent infections mean those chronic infections which recur by same causal agents with similar drug responsiveness after apparent relief following full course of recommended antimicrobial management. | 2017 | 28367029 |
| survival after lung transplantation for cystic fibrosis in sweden†. | in sweden, lung transplantation has been performed in patients with end-stage lung disease since 1990. we assessed survival after lung transplantation for cystic fibrosis (cf) with focus on early mortality and outcome for patients infected with certain multiresistant bacteria, considered a relative contraindication for lung transplantation. | 2017 | 28364441 |
| mycobacterial arthritis and synovitis in painted reed frogs (hyperolius marmoratus). | several species of atypical mycobacteria have been isolated from wild and captive amphibians. in captive anurans, cutaneous and visceral mycobacteriosis are common and can result in significant mortality, particularly when animals are immunocompromised. mycobacterial arthritis and synovitis are reported rarely in amphibians. we describe 20 cases in painted reed frogs (hyperolius marmoratus), which presented with cachexia, limb paresis or paralysis or 'spindly leg syndrome'. histopathology reveal ... | 2017 | 28233523 |
| epidemiology of nontuberculous mycobacterial lung disease and tuberculosis, hawaii, usa. | previous studies found hawaiians and asian-americans/pacific islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (ntmpd) and tuberculosis (tb). to better understand ntm infection and tb risk patterns in hawaii, usa, we evaluated data on a cohort of patients in hawaii for 2005-2013. period prevalence of ntmpd was highest among japanese, chinese, and vietnamese patients (>300/100,000 persons) and lowest among native hawaiians and other pacific islande ... | 2017 | 28221128 |
| pulmonary nontuberculous mycobacteria-associated deaths, ontario, canada, 2001-2013. | survival implications of nontuberculous mycobacterial pulmonary disease (ntm-pd) and ntm pulmonary isolation without disease (ntm-pi) are unclear. to study deaths associated with ntm-pd and ntm-pi and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined ntm-pd or ntm-pi diagnosed during 2001-2013 in ontario, canada. we used propensity score matching and cox proportional hazards models to compare survival. among 9,681 ntm-pd ... | 2017 | 28221106 |
| high incidence of non-tuberculous mycobacteria-positive cultures among adolescent with cystic fibrosis. | we evaluated the prevalence of non-tuberculous mycobacteria (ntm)-positive cultures among our cystic fibrosis (cf) center patients, reviewed risk factors for ntm positivity, and determined its impact on lung function evolution. | 2017 | 28202251 |
| a patient-based analysis of the geographic distribution of mycobacterium avium complex, mycobacterium abscessus, and mycobacterium kansasii infections in the united states. | 2017 | 28390637 | |
| post-lower segment cesarean section wound infection with mycobacterium abscessus. | 2017 | 28366911 | |
| successful use of linezolid for refractory mycobacterium abcessus infection: a case report. | a 51-year-old male patient was receiving treatment for mycobacterium abscessus infection for approximately 10 years. however, as his condition gradually progressed to type ii respiratory insufficiency, he was referred to our hospital, which was near his home. computed tomography on his first visit revealed an abscess in the right lower lobe. because respiratory insufficiency was evident, he was admitted the same day. we began treatment with meropenem, amikacin, and clarithromycin, but his sympto ... | 2018 | 29234594 |
| association between sequevar and antibiotic treatment outcome in patients with mycobacterium abscessus complex infections in japan. | macrolide susceptibility differs between subspecies in the mycobacterium abscessus complex, likely due to differences in erm(41) sequevars. patients with m. abscessus complex infection generally show poor clinical outcomes in response to antibiotic treatment. here, the association between genotype and treatment outcome was investigated. | 2018 | 29227218 |
| mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. | in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-sct), post-transplant lung infection is critical for their prognosis. mycobacterium abscessus complex is not fully recognized as a nontuberculous mycobacteria (ntm) pathogen of post-sct lung infection. here, we present three post-allogeneic sct patients who developed pulmonary infection caused by m. abscessus complex including m. abscessus and m. massiliense. in all three cases, macrolide antibiotics had been adminis ... | 2018 | 28988958 |
| mycobacterium abscessus smooth and rough morpohotypes form antimicrobial-tolerant biofilm phenotypes but are killed by acetic acid. | mycobacterium abscessus has emerged as an important pathogen in people with chronic inflammatory lung diseases such as cystic fibrosis, and recent reports suggest that it may be transmissible by fomites. m. abscessus exhibits two major colony morphology variants: a smooth morphotype (masm ) and a rough morphotype (marg ). biofilm formation, prolonged intracellular survival, and colony variant diversity can each contribute to the persistence of m. abscessus and other bacterial pathogens in chroni ... | 2018 | 29311080 |
| survival of pathogenic mycobacterium abscessus subsp. massiliense in acanthamoeba castellanii. | we used an amoeba model to study the intracellular growth and cytotoxicity of clinical strains of mycobacterium abscessus subsp. massiliense (mabsm) isolated from 2 patients (one with cystic fibrosis, the other one with idiopathic bronchiectasis) during the early (smooth colonies) and late stage (rough colonies) of chronic pulmonary infection. acanthamoeba castellanii were infected with mabsm (moi 100) and samples collected every 24 h for 72 h. results showed mabsm is able to survive in trophozo ... | 2018 | 29056478 |
| identification of genes required for mycobacterium abscessus growth in vivo with a prominent role of the esx-4 locus. | mycobacterium abscessus, a rapidly growing mycobacterium (rgm) and an opportunistic human pathogen, is responsible for a wide spectrum of clinical manifestations ranging from pulmonary to skin and soft tissue infections. this intracellular organism can resist the bactericidal defense mechanisms of amoebae and macrophages, an ability that has not been observed in other rgm. m. abscessus can up-regulate several virulence factors during transient infection of amoebae, thereby becoming more virulent ... | 2018 | 29343644 |
| amplification of hsp 65 gene and usage of restriction endonuclease for identification of non tuberculous rapid grower mycobacterium. | the rapid grower mycobacteria have emerged as significant group of human pathogen amongst the runyon group iv organisms that are capable of causing infection in both the healthy and immunocompromised hosts. study aimed to identification of species amongst rapid grower non tuberculous mycobacterial isolates by polymerase chain reaction - restriction enzyme analysis (pra). analysis and comparison of results with standard biochemical tests. | 2018 | 29332650 |
| in vitro evaluation of povidone-iodine and chlorhexidine against outbreak and nonoutbreak strains of mycobacterium abscessus using standard quantitative suspension and carrier testing. | povidone-iodine (pi) and chlorhexidine (chx) are widely used antiseptics active against conventional staphylococcus aureus, enterobacteriaceae, candida species, and viruses, but their efficacy against mycobacterium abscessus remains unproven. we determined the in vitro potency of alcoholic pi and chx against m. abscessus subsp. abscessus (atcc 19977), m. abscessus subsp. bolletii (bcrc 16915), and our outbreak strain of m. abscessus subsp. massiliense (tpe 101) in reference to staphylococcus aur ... | 2018 | 29061748 |
| molecular mechanisms of intrinsic streptomycin resistance in mycobacterium abscessus. | streptomycin, the first drug used for the treatment of tuberculosis, shows limited activity against the highly resistant pathogen mycobacterium abscessus we recently identified two aminoglycoside-acetylating genes [aac(2') and eis2] which, however, do not affect susceptibility to streptomycin. this suggests the existence of a discrete mechanism of streptomycin resistance. m. abscessus blastp analysis identified mab_2385 as a close homologue of the 3″-o-phosphotransferase [aph(3″)] from the oppor ... | 2018 | 29061744 |
| mycobacterium abscessus, a taxonomic puzzle. | 2018 | 29139343 | |
| in vitro activity between linezolid and other antimicrobial agents against mycobacterium abscessus complex. | linezolid (lzd) serves as an effective option in the treatment of mycobacterium abscessus complex (mabc) infection. unfortunately, the combined activities of lzd with other antimicrobial agents against mabc have not been evaluated systemically. in this study, we randomly selected 32 mycobacterium abscessus and 32 mycobacterium massiliense isolates for the determination of in vitro synergistic effect between lzd and other antimicrobial agents, including amikacin (amk), moxifloxacin (mox), cefoxit ... | 2018 | 29089153 |