Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the taiwan cobra (naja naja atra). | a cardiotoxin-like basic polypeptide from the venom of naja naja atra is homologous to cardiotoxins from the same venom, but much less toxic. to determine if it acts like the cardiotoxins its depolarizing ability was measured. it was about 10 times less potent than the cardiotoxins. five amino acids are conserved in the sequences studied, on the exposed second and third loops of the toxin backbone. they may be part of the toxins' interactive site. | 1987 | 3629619 |
| synthesis of prodan-phosphatidylcholine, a new fluorescent probe, and its interactions with pancreatic and snake venom phospholipases a2. | a new fluorescent probe, prodan-pc, was synthesized by incubating thio-pc, a thiol ester analogue of phosphatidylcholine [1,2-bis(decanoylthio)-1,2-dideoxy-sn-glycero-3-phosphocholine], with acrylodan, a fluorescent thiol-reactive reagent [6-acryloyl-2-(dimethylamino)naphthalene], in the presence of phospholipase a2, which served to generate lysothio-pc in situ. prodan-pc (ppc) showed maximum absorption in ethanol at 370 nm. the fluorescence emission spectrum showed maximum emission at 530 nm in ... | 1987 | 3651404 |
| bites by the philippine cobra (naja naja philippinensis): an important cause of death among rice farmers. | we investigated mortality from cobra (naja naja philippinensis) bite among filipino rice farmers. village records in one area were examined and we conducted a careful survey in this and two additional areas among inhabitants at varying risk for snakebite. the death rate from cobra bite was estimated to be as high as 107.1 deaths per 100,000 population per year at one site. most victims were young (median age 17) and 98% were males. only 8% of the victims studied reached a hospital. the confirmed ... | 1987 | 3688317 |
| multiple effects of alpha-toxins on the nicotinic acetylcholine receptor. | very low concentrations (5 nm) of alpha-toxin from the venom of naja naja atra produced a characteristic fade in muscle compound action potential and tetanus induced by repetitive nerve stimulation which was identical to the effects of curare. high concentrations of alpha-toxin and all concentrations of alpha-bungarotoxin reduced the response but produced very little fade in comparison to curare. these results suggest that alpha-toxins have more than one effect at the neuromuscular junction. | 1987 | 3691793 |
| the binding site for alpha-bungarotoxin resides in the sequence 188-201 of the alpha-subunit of acetylcholine receptor: structure, conformation and binding characteristics of peptide [lys] 188-201. | in order to study where the binding site of cholinergic agents is in the sequence of the alpha-subunit of nicotinic acetylcholine receptor (achr), we have synthetized 3 peptides with an amino acid sequence corresponding to the following sequences of the alpha-subunit of torpedo californica achr: 125-143, 158-167, [lys] 188-201. for binding studies the peptides were immobilized on sepharose 4b. only the peptide [lys] 188-201 binds 125i-alpha-bungarotoxin (alpha-bgtx) with kd of 1.03 microm. the b ... | 1987 | 3696481 |
| analysis of folding intermediates from the main toxin of naja naja samarensis containing two blocked cysteines. | the formation of folding intermediates blocked by iodoacetate from the main toxin of naja naja samarensis was monitored by fplc and the populations were identified by amino acid analyses. we have determined conditions allowing for the highest yield in the populations with two blocked cysteines. the free cysteines remaining under these conditions were labeled with iodo[14c]acetate and localized by peptide mapping in one of the products isolated by ion-exchange chromatography (nt3iii). we have als ... | 1986 | 3699158 |
| actions of cardiotoxins from the southern chinese cobra (naja naja atra) on rat cardiac tissue. | the cardiotoxic actions of southern chinese cobra (naja naja atra) venom have been investigated. cardiotoxicity accounted for lethality of crude venom in anaesthetized rats and cardiotoxic polypeptides constituted the bulk of the venom when it was fractionated by cm-sephadex chromatography. the cardiotoxic actions of these polypeptides were investigated in isolated cardiac tissue. actions of cardiotoxins on rate, force and intracellular potentials occurred more readily in ventricular tissue and ... | 1986 | 3715895 |
| [reversible inhibition of acetylcholinesterases of different origins by quaternary phosphonium compounds]. | studies have been made on the reversible inhibition of acetylcholinesterase activity from the erythrocytes of man, horse and camel, the electric organ of the skate torpedo marmorata and eel electrophorus electricus, the venom of the snakes naja naja and vipera lebetina, the brain of the pigeon columba livia by tetraphenyl-, triphenylalkyl- and tributyrylalkyl-phosphonium salts. the investigated phosphonium inhibitors exhibit an evident specificity in their action: they were more effective in inh ... | 1986 | 3716682 |
| [effect of modification of naja naja oxiana neurotoxin ii on the stoichiometry of its complexes with acetylcholine receptor]. | it was discovered that illumination of the complex formed by the solubilized acetylcholine receptor from torpedo marmorata and lys25-p-azidobenzoyl derivative of neurotoxin ii results in the appearance on the receptor of up to 4 additional binding sites. acetylcholine and neurotoxin ii, but not the long-chain neurotoxins bind specifically to these sites. the additional binding sites could be also detected after illuminating the receptor complex with other photoactivable derivatives, provided the ... | 1986 | 3718547 |
| hypotensive compounds isolated from the dried body of naja naja kaouthia lesson. i. isolation of inosine as a hypotensive principle and structure-activity study of related compounds. | 1986 | 3719873 | |
| conformation of cardiotoxins isolated from naja naja siamensis. | 2013 | 3733141 | |
| rate-determining step in phospholipase a2 mechanism. 18o isotope exchange determined by 13c nmr. | h2(18)o isotope exchange into specifically 13c-labeled substrate was used to obtain information on the rate-limiting step in the action of the phospholipase a2 from the venom of the indian cobra (naja naja naja). incorporation of 18o was detected by the effect of 18o on 13c chemical shifts in 13c nmr. the enzymatic hydrolysis of a micellar phosphatidylcholine analogue of platelet-activating factor 1-alkyl-2-[1-13c]lauroyl-sn-glycero-3-phosphorylcholine proceeds by an o-acyl cleavage of the sn-2 ... | 1986 | 3745162 |
| selectivity and regulation in the phospholipase a2-mediated attack on cholinergic synaptic vesicles by beta-bungarotoxin. | the total fatty acid composition of purified torpedo californica electric organ synaptic vesicles was determined by glc analysis of methyl esters. limit amounts of fatty acids released by high concentrations of either beta-bungarotoxin (beta-butx) or naja naja venom phospholipase a2 (pla2) acting in deoxycholate are reported. the time and enzyme concentration dependence for beta-butx- and pla2-induced release of fatty acids from intact synaptic vesicles indicate that pla2 is 100- to 1,000-fold m ... | 1986 | 3746303 |
| 1-stearyl,2-stearoylaminodeoxy phosphatidylcholine, a potent reversible inhibitor of phospholipase a2. | 1-stearyl, 2-stearoylaminodeoxy phosphatidylcholine, a structurally modified phospholipid substrate analog exhibits potent and reversible inhibition of phospholipase a2 from cobra venom (n. naja naja). the apparent ki values determined in two different assay systems employing phosphatidylcholine-surfactant mixed micelles are in reasonable agreement (40 microm and 16 microm) and indicate that the inhibitor binds to the enzyme as much as two orders of magnitude more tightly than does dipalmitoyl p ... | 1986 | 3755338 |
| effects of modification of tyrosines 3 and 62 (63) on enzymatic and toxicological properties of phospholipases a2 from naja nigricollis and naja naja atra snake venoms. | previously we selectively modified his (48), arg, lys, asp, glu and trp residues in the basic phospholipase a2 from naja nigricollis and the acidic phospholipase a2 from n. n. atra snake venoms. evidence was obtained for the existence of separate but perhaps overlapping sites responsible, respectively, for their enzymatic and pharmacological properties. we have now modified one or two (tyr 3, tyr 62 [63], tyr 3 + 62 [63]) out of the nine tyrosine residues in these enzymes using p-nitrobenzenesul ... | 1986 | 3775785 |
| self-association and active enzyme forms of naja naja naja and crotalus atrox phospholipase a2 studied by analytical ultracentrifugation. | the dimerization of phospholipase a2 (plpa2) from naja naja naja (pakistani cobra) and crotalus atrox (western diamondback rattlesnake) has been studied from ph 2.5 to 11 at 20 degrees c in 1 mm cacl2, 0.21 m ionic strength. for the c. atrox enzyme, it was found necessary to use a combination of sedimentation equilibrium and fluorescence yield data to analyze the association. sedimentation equilibrium in the analytical ultracentrifuge sufficed for the study of the n. naja plpa2. in the region of ... | 1986 | 3801457 |
| a one-step isolation procedure for phospholipase a2-free cobra venom factor by fast protein liquid chromatography. | a very rapid and efficient procedure for isolation of cobra venom factor (cof) from naja naja venom is presented. the method is based on mono q anion exchange chromatography on a system for fast protein liquid chromatography (fplc). cof was eluted by a buffer of ph 7.4 at 280 mm salt. a purification of 33.7 x was reached with a yield of at least 27%. contamination with phospholipase was under the detection limit of a sensitive radiometric assay (less than 25 ppm), while the starting material con ... | 1987 | 3819435 |
| action of cobra venom phospholipase a2 on large unilamellar vesicles: comparison with small unilamellar vesicles and multibilayers. | phospholipase a2 (naja naja naja) catalyzes the hydrolysis of dipalmitoyl phosphatidylcholine in small unilamellar vesicles (suvs) with a faster initial rate than in large unilamellar vesicles (luvs) and multilamellar vesicles (mlvs). for the suvs, the hydrolysis was initially faster for gel phase than liquid crystalline phase phospholipid. for both luvs and mlvs, hydrolysis was low except in a small temperature range around the thermotropic phase transition of the phospholipid. in this temperat ... | 1985 | 3838567 |
| two new inhibitors of phospholipase a2 produced by penicillium chermesinum. taxonomy, fermentation, isolation, structure determination and biological properties. | plastatin and the known fungal metabolite, luteosporin, have been isolated from fermentations of penicillium chermesinum as inhibitors of porcine pancreatic phospholipase a2 (pla2). structure 1 for plastatin was deduced from its spectroscopic properties. plastatin and luteosporin inhibited pancreatic pla2 competitively with ki values of 0.89 microm and 12.8 microm, respectively. pla2 preparations from naja naja and crotalus adamanteus were not significantly inhibited by plastatin and luteosporin ... | 1985 | 3839502 |
| effect of alkylation of tryptophan residues on the enzymatic and pharmacological properties of snake venom phospholipase a2. | snake venom phospholipases a2 show a remarkable degree of amino acid sequence homology yet differ markedly in enzymatic and pharmacological activities. the basic phospholipase a2 from naja nigricollis venom has much greater lethal potency, cardiotoxicity, hemolytic and anticoagulant activity than the acidic or neutral enzymes from naja naja atra or hemachatus haemachatus venoms, respectively, even though it has lower enzymatic activity than the latter two enzymes. previous studies in which we se ... | 1985 | 3924381 |
| real-time fluorescence polarization measurements: interaction of phospholipase a2 with a fluorescent lecithin derivative. | we have modified an slm 4800 fluorometer to allow continuous measurement of fluorescence polarization. the modifications included construction of simple mechanical and electronic accessories which allowed polarizer position to be program-controlled by an hp 9815 calculator. with these modifications we were able to follow the interaction of the fluorescent lipid analog 1-acyl-2-(n-4-nitrobenzo-2-oxa-1,3-diazole)-aminododecanoyl phosphatidylcholine (i) with naja-naja venom phospholipase a2 (pla2) ... | 2013 | 3924989 |
| affinity chromatography of phospholipase a2 from naja naja naja (indian cobra) venom. | a rapid and improved purification procedure is described for phospholipase a2 from the indian cobra, naja naja naja. the procedure is based on affinity chromatography of the venom through affi-gel blue to obtain a 9-fold purification in one step. however, as there are multiple forms of the enzyme in the venom and other proteins do bind to affi-gel blue, further purification is achieved by de-11 cellulose. finally, a minor contaminant is removed by sulfopropyl sephadex c-25 chromatography. the re ... | 1985 | 3927524 |
| [the detoxification of naja naja atra venom and preparation of potent antivenin]. | the 99.2% toxicity of naja naja atra venom can be detoxified by treatment with 0.25% ga (glutaraldehyde) solution at ph 6.8 and still remains its antigenicity. using the ga treated venom incorporated with freund's complete adjuvant as immunogen, the titer of immune horse sera can be enhanced rapidly. the modified immunization method not only shortened the period of immunization (from 180 to 60 days), but also increased the potency of immune sera (from 75 to 170 units). the method also diminished ... | 1985 | 3933920 |
| aggregation studies on fluorescein-coupled cobra venom phospholipase a2. | phospholipase a2 from naja naja naja venom (indian cobra) undergoes a concentration-dependent aggregation, and at an assay concentration of 1 microgram ml-1, it exists as a monomer. however, there is some evidence that the enzyme is actually active as a dimer or higher order aggregate. previous attempts to determine the aggregation state of the enzyme under actual assay conditions were thwarted by experimental difficulties due in part to the low enzyme concentrations required. this aggregation h ... | 1985 | 3936540 |
| comparative study on the cardiac actions of bovine parathyroid hormone (1-34). | the cardiac stimulatory effects of bovine parathyroid hormone (1-34) [bpth-(1-34)] were studied on isolated atria and ventricular strips from cobra snakes (naja naja), ducklings (anas platyrhynchos), pigeons (columba livia), japanese quails (coturnix coturnix japonica), laboratory rats (rattus norvegicus), and dogs (canis familiaris). in all atrial preparations, bpth-(1-34) caused positive chronotropism. this suggests that the chronotropic effect of pth is ubiquitous among the terrestrial verteb ... | 1986 | 3940926 |
| effects of beta-bungarotoxin and naja naja atra snake venom phospholipase a2 on acetylcholine release and choline uptake in synaptosomes. | beta-bungarotoxin is a potent presynaptically acting snake venom toxin that exhibits phospholipase a2 activity. we compared the effects of beta-bungarotoxin and a less toxic snake venom phospholipase a2 on synaptosomal 3h-acetylcholine release and 3h-choline uptake. the purpose of these experiments was to study the mode by which beta-bungarotoxin inhibits 3h-acetylcholine release in this preparation. under non-depolarizing conditions, both beta-bungarotoxin and naja naja atra phospholipase a2 st ... | 1986 | 3952766 |
| the relationship between high-affinity noncatalytic binding of snake venom phospholipases a2 to brain synaptic plasma membranes and their central lethal potencies. | the basic phospholipase a2 from naja nigricollis (african spitting cobra) snake venom is enzymatically less active but more toxic than the acidic phospholipase a2 from naja naja atra (taiwan cobra) snake venom, following injection into the right lateral ventricle of the brain of rats. when radiolabeled with 125i, these phospholipases a2 retained enzymatic activities and lethal potencies. both enzymes bound with high affinity and specificity to brain synaptic plasma membrane preparations in vitro ... | 1986 | 3964691 |
| methyl branching in short-chain lecithins: are both chains important for effective phospholipase a2 activity? | several seven-carbon fatty acyl lecithins with varied acyl chain branching have been synthesized and characterized as potential phospholipase a2 substrates. micellar bis(4,4-dimethylpentanoyl) phosphatidylcholine, bis(5-methylhexanoyl)phosphatidylcholine, bis(3-methylhexanoyl)phosphatidylcholine, and bis(2-methylhexanoyl)phosphatidylcholine are poor substrates for phospholipase a2 (naja naja naja). these branched lecithins also inhibit the hydrolysis of diheptanoylphosphatidylcholine by the enzy ... | 1985 | 3986178 |
| [biospecific adsorption chromatography of phospholipase a2 from different sources]. | methods of biospecific adsorption chromatography of phospholipase a2 obtained from porcine pancreas and naja naja oxiana, vipera ursini renardi, vespa orientalis venoms were developed. granulated polyamide with covalently linked phosphatidylethanolamine were used as an affinity adsorbent. chemical inertness of linked phosphatidylethanolamine to the hydrolytic action of phospholipase a2 and its high affinity for biospecific complexes are shown. forms of phospholipase a2 different in their affinit ... | 1985 | 3991479 |
| cytolytic activity of cytotoxin isolated from indian cobra venom against experimental tumor cells. | cytolytic activity of cytotoxin isolated from the venom of the indian cobra (naja naja) on experimental tumor cells was far stronger than that on normal cells such as peritoneal exudate cells, spleen cells, and erythrocytes of the rat. the effect on yoshida sarcoma cells was temperature-dependent, being stronger at 37 degrees c than at 0 degrees c. intramolecular disulfide linkages and free amino groups in the cytotoxin molecule were shown to be essential for the lytic action on the cell membran ... | 1985 | 4015662 |
| activation, aggregation, and product inhibition of cobra venom phospholipase a2 and comparison with other phospholipases. | the kinetics of phospholipid hydrolysis by cobra venom phospholipase a2 were examined and compared to those of phospholipase a2 from porcine pancreas, crotalus adamanteus (rattlesnake) venom, and bee venom. only the enzyme from naja naja naja (cobra) venom was found to be activated significantly by phosphorylcholine-containing compounds when hydrolyzing phosphatidylethanolamine. the cobra venom enzyme was also the only one in which these activators induced protein aggregation. the parallel speci ... | 1985 | 4030786 |
| biochemical characterization of two nicotinic receptors from the optic lobe of the chick. | we have studied putative nicotinic acetylcholine receptors in the optic lobe of the newborn chick, using 125i-labeled alpha-bungarotoxin, a specific blocker of acetylcholine receptors in the neuromuscular junction, and [3h]acetylcholine, a ligand which in the presence of atropine selectively labels binding sites of nicotinic character in rat brain cortex (schwartz et al., 1982). [3h]acetylcholine binds reversibly to a single class of high affinity binding sites (kd = 2.2 x 10(-8) m) which occur ... | 1985 | 4055785 |
| contractile response of the isolated dorsal aorta of the snake to angiotensin ii and norepinephrine. | vasopressor action is a phylogenetically old function of angiotensin (ang) ii. the action can be ascribed to both direct activation of vascular ang ii receptors and through catecholamine release. in the rat snake, ptyas korros, the possible presence of common adrenergic-ang receptors and their involvement in this action have been proposed. in order to elucidate the vasopressor mechanism of ang ii in the snake, and to test the presence of common adrenergic-ang receptors, the contractile response ... | 1985 | 4065534 |
| [synthesis of tritium-labeled n,n-dimethyl-2-phenylaziridinium and its reaction with acetylcholinesterase]. | the synthesis of tritium-labeled n,n-demethyl-2-phenylaziridinium has been described. the specific radioactivity of the product obtained was 1,06 tbq/mmole. kinetics of incorporation of this radioactive label into acetylcholinesterase of cobra venom (naja naja oxiana) has been studied at 1,05 mm ligand concentration (25 degrees c, ph 7,50. 0,15 m phosphate buffer). under these conditions two molecules of the radioactive label have been found to react with the enzyme. one molecule incorporates fa ... | 1985 | 4074397 |
| circular dichroism study of the unfolding-refolding of a cardiotoxin from taiwan cobra (naja naja atra) venom. | circular dichroism spectroscopy has been used to study the unfolding-refolding process of a cardiotoxin from taiwan cobra (naja naja atra) venom upon addition of fluoroalcohols or sodium dodecyl sulfate (sds) to its aqueous solution. in these experiments, the disulfide bridges remained intact. the unfolding process has been found to be reversible both for fluoroalcohols and for sds unfolding. the reversibility of the unfolding-refolding process of cardiotoxin in aqueous mixtures of fluoroalcohol ... | 2014 | 4074722 |
| effect of pure venom phospholipase a2 from the central asian cobra (naja naja oxiana eichwald) on oxidative functions of rat liver mitochondria. | 1985 | 4077115 | |
| [central action of snake venoms on body temperature in rats]. | experiments on rats were made to study the effect on the body temperature of the rat of intracerebroventricular injection of venoms of indian cobra, north american rattle snake, and central asian shchitomordnik. it was established that the rise of rectal temperature by 1.5-2.0 degrees c after 90 min was evoked by cobra venom alone. that increase in the body temperature was not prevented by pretreatment with the protein synthesis inhibitors anisomycin or cycloheximide, but was completely abolishe ... | 1985 | 4085638 |
| amino acid sequence of a cardiotoxin-like basic polypeptide (clbp) with low cytotoxic activity isolated from the venom of the formosan cobra (naja naja atra). | a cardiotoxin-like basic polypeptide, designated as clbp, was isolated from the venom of naja naja atra by gel filtration on sephadex g-50 followed by cm-cellulose chromatography. the cytotoxicity toward yoshida sarcoma cells and lethal toxicity toward mice of clbp were both one-order lower than those of cardiotoxins and cobrotoxin, respectively. clbp is a single polypeptide consisting of 61 amino acid residues with four intramolecular disulfide linkages. the amino acid sequence of clbp shows a ... | 1985 | 4091854 |
| kinetics of the hydrolysis of monodispersed dihexanoyllecithin catalyzed by a cobra (naja naja atra) venom phospholipase a2. | the hydrolysis of 1,2-dihexanoyl-sn-glycero-3-phosphorylcholine (dic6pc), catalyzed by a cobra (naja naja atra) venom phospholipase a2, was studied at 25 degrees c ionic strength 0.1 in the presence of 3-10 mm ca2+, which can saturate the ca2+-binding site of the enzyme. the initial velocity data, obtained at various concentrations of the substrate below the critical micellar concentration (cmc), were analyzed according to the michaelis-menten equation. the km value was practically independent o ... | 2013 | 4093439 |
| positional distribution of fatty acids in cardiolipin of mitochondria from 21-day-old rats. | pure cardiolipins (1,3-diphosphatidylglycerol) were prepared from mitochondria of heart, liver and kidney from 21-day-old male wistar rats and submitted to naja naja venom phospholipase a2 (ec 3.1.1.4) action. incubation conditions were controlled carefully, and a complete hydrolysis of cardiolipin to lysocardiolipin (di [1 (1'') acyl sn-glycero-3-phosphoryl] 1',3'-sn-glycerol) and fatty acids from positions 2(2'') was obtained in less than two hr practically without side reactions. cardiolipins ... | 1985 | 4094521 |
| studies on purified eel acetylcholine receptor and anti-acetylcholine receptor antibody. | rabbit antiserum against purified electrophorus electricus acetylcholine receptor is studied using an immunoprecipitin assay to measure either antibody titer or concentration of toxin-binding sites in solubilized receptor preparations. this antiserum, unlike control serum, blocks the electrophysiological response of the electroplax to carbamylcholine. toxin (alpha-neurotoxin, naja naja) and several cholinergic ligands produce partial inhibition of the reaction of antiserum with purified acetylch ... | 1973 | 4128544 |
| immunization studies with naja naja venom detoxified by photooxidation. | 1968 | 4170737 | |
| phospholipase isoenzymes from naja naja venom. i. purification and partial characterization. | 1973 | 4202693 | |
| chemical modification of tyrosine residue in "toxin b" from the venom of the indian cobra, naja naja. | 1974 | 4207860 | |
| chemical modification of the tryptophan residue in toxin b from the venom of the indian cobra. | 1974 | 4208572 | |
| immunochemical characterization of naja naja siamensis toxin and of a chemically modified toxin. | 1974 | 4214148 | |
| [comparative hemolysis experiments on guinea pig and rat erythrocytes in vitro with phospholipase a and direct lytic factor from cobra (naja naja) venom]. | 1971 | 4250101 | |
| steroid synthesis by the seminiferous tubules of the snake naja naja. | 2014 | 4256856 | |
| modification of amino groups in naja naja neurotoxins and the preparation of radioactive derivatives. | 1972 | 4259996 | |
| inhibition of na + - and k + -activated atpase by the direct lytic factor of cobra venom (naja naja). | 1972 | 4261171 | |
| chemical modifications of the postsynaptic naja naja neurotoxins. | 1972 | 4267235 | |
| glycoproteins as components of the lethal factors in cobra venom (naja naja). | 1965 | 4285392 | |
| effect of naja naja atra venom on cytochrome c oxidase, l-ascorbic acid oxidase, peroxidase, and catalase. | 1965 | 4287255 | |
| the hydrolysis of unimolecular films of p32-labelled lecithin, phosphatidylethanolamine and phosphatidylinositol with phospholipase a (naja naja venom). | 1966 | 4287839 | |
| amino acid sequence of cytotoxin i from the venom of the indian cobra (naja naja). | 1971 | 4332596 | |
| the amino acid sequence of cytotoxin ii from the venom of the indian cobra (naja naja). | 1972 | 4340873 | |
| possible implication of glutathione reductase in haemolysis by the direct lytic factor of cobra venom (naja naja). | 1972 | 4404949 | |
| amino acid sequence of neurotoxin i from naja naja oxiana venom. | 1974 | 4411932 | |
| the major lethal neurotoxin of the venom of naja naja philippinensis. purification, physical and chemical properties, partial amino acid sequence. | 1974 | 4426734 | |
| investigation of the naja naja siamensis toxin binding site of the cholinergic receptor protein from torpedo electric tissue. | 1974 | 4430347 | |
| the isolation and sequence determination of a cytotoxin from the venom of the middle-asian cobra naja naja oxiana. | 1974 | 4435217 | |
| effect of cobra (naja naja) venom on succinic dehydrogenase and cholinesterase of rat tissue. | 1974 | 4442994 | |
| convulsant activity of naja naja venom and its phospholipase a component. | 1974 | 4458108 | |
| arbovirus infections in reptiles: immunological evidence for a high incidence of japanese encephalitis virus in the cobra naja naja. | 1974 | 4460310 | |
| [the effect of the venom on the central asian cobra naja naja oxiana on tyrosine-c-14 incorporation in the cellular structures of mouse liver]. | 1974 | 4462296 | |
| appearance of acetylcholine receptors during differentiation of a myogenic cell line. | acquisition of acetylcholine receptors during differentiation of a clonal myoblast cell line was monitored with a neurotoxin isolated from venom of the indian cobra naja naja. toxin bound specifically and reversibly to acetylcholine receptors of the differentiated cells. specificity of the binding reaction was assayed by measurement of the ability of various cholinergic agonists and antagonists to compete with neurotoxin for its binding site. the rate of toxin binding paralleled the rate of inac ... | 1972 | 4507600 |
| chemical studies on phospholipase a from formosan cobra (naja naja atra) venom. | 1972 | 4512906 | |
| the role of direct lytic factor (dlf) and phospholipase-a in the local hemorrhagic effect of naja naja venom. | 1972 | 4512909 | |
| the affinity-labeling of partially purified acetylcholine receptor from electric tissue of electrophorus. | the receptor for acetylcholine was partially purified by affinity chromatography of an extract in triton x-100 of membrane fragments from electric tissue. the receptor was assayed, after its reduction with dithiothreitol, by reaction with the affinity-alkylating agent, [methyl-(3)h]4-(n-maleimido)-benzyltrimethylammonium iodide. alternative labeling procedures, one useful for routine assay of picomole quantities of receptor and the other for labeling larger quantities of receptor, are described. ... | 1973 | 4519650 |
| irradiated cobra (naja naja philippinensis) venom. | 1972 | 4539443 | |
| local necrosis induced by cobra (naja naja atra) venom. | 1972 | 4539445 | |
| amino acid sequences of toxin a and two basic proteins from the venom of the indian cobra (naja naja). | 1972 | 4539448 | |
| seasonal changes in the secretory activity of adrenal gland of the cobra (naja naja, linn.). | 1972 | 4635455 | |
| isolation of the nicotinic acetylcholine receptor by biospecific chromatography on insolubilized naja naja neurotoxin. | 1972 | 4646866 | |
| localization of the four disulfide bridges in cytotoxin ii from the venom of the indian cobra (naja naja). | 1972 | 4674343 | |
| haemolysis of washed human red cells by the combined action of naja naja phospholipase a 2 and albumin. | 1972 | 4674345 | |
| kinetic dependence of phospholipase a 2 activity on the detergent triton x-100. | a kinetic analysis is presented for the dependence of one form of phospholipase a(2) from cobra (naja naja) venom on the presence of the nonionic detergent triton x-100 for its activity towards egg phosphatidylcholine and synthetic dipalmitoyl glycerophosphorylcholine as substrates. an automatic recording ph-stat apparatus was employed in order to continuously monitor enzyme activity. the results obtained in this study are interpreted in terms of a change in the physical state of the phospholipi ... | 1973 | 4698263 |
| irradiated cobra (naja naja philippinensis) venom. | 1973 | 4734465 | |
| amino acid sequence of neurotoxin ii from naja naja oxiana venom. | 1973 | 4747603 | |
| phospholipase isoenzymes from naja naja venom. ii. phospholipase a and b activities. | 1973 | 4762267 | |
| localization of the five disulfide bridges in toxin b from the venom of the indian cobra (naja naja). | 1973 | 4767311 | |
| modification of the invariant tryptophan residue of two naja naja neurotoxins. | 1973 | 4776457 | |
| amino acid sequence of oxiana alpha, the main neurotoxin of the venom of naja naja oxiana. | 1974 | 4850498 | |
| comparison of naja naja siamensis and naja naja atra venoms. | 1968 | 4966517 | |
| [a study of the fractions obtained by chromatography of the venom of naja naja atra on sulphoethyl-sephadex]. | 1968 | 4971838 | |
| neurotoxin from venom of the cobra, naja naja siamensis. purification and radioactive labeling. | 1972 | 5027738 | |
| role of cardiotoxin and phospholipase a in the blockade of nerve conduction and depolarization of skeletal muscle induced by cobra venom. | 1. the effects of phospholipase a (pha), cardiotoxin (ctx) and neurotoxin (cobrotoxin) isolated from formosan cobra (naja naja atra) venom on conduction of the rat phrenic nerve and membrane potential of the rat diaphragm were studied.2. phospholipase a, lysolecithin and cobrotoxin were without effect on the axonal conduction. cardiotoxin was the only active agent in cobra venom, but it was less potent than the crude venom.3. the blocking action of cardiotoxin was markedly accelerated by the sim ... | 1972 | 5041453 |
| some effects of guinea pig serum and heparin on hemolysis induced by naja naja, agkistrodon piscivorus and apis mellifera venom. | 1972 | 5070580 | |
| isolation of the principal neurotoxins of naja naja subspecies from the asian mainland. | 1972 | 5072086 | |
| amino acid sequence of toxin a from the venom of the indian cobra (naja naja). | 1971 | 5125232 | |
| nerve growth factor from cobra venom. | the chemical and biological properties of the nerve growth factor isolated from naja naja venom are described. the nerve growth promoting activity appears to be distinct from the most commonly known enzymes and toxins present in the venom. the purified nerve growth factor from cobra venom has properties remarkably similar to those of the nerve growth factor isolated from mouse submaxillary gland. these findings are discussed in connection with the problem of the physiological function of this un ... | 1970 | 5267146 |
| chemical modification of cobratoxin from the venom of formosan cobra (naja naja atra). | 1970 | 5313270 | |
| purification and some properties of toxin a from the venom of the indian cobra (naja naja). | 1971 | 5314268 | |
| comparison of hemorrhagic factors of the venoms of naja naja, agkistrodon piscivorus and apis mellifera. | 1970 | 5315472 | |
| chemical composition of naja naja: extractable lipids. | 1969 | 5358066 | |
| long-lasting convulsant effect on the cerebral cortex of naja naja venom. | 1. a neurotoxic fraction has been prepared from indian cobra venom (naja naja) by column chromatography on cm sephadex.2. when assayed for lethality in mice, or for neuromuscular blocking potency in the rat phrenic nerve-diaphragm preparation, this fraction was 2.4-2.9 times as potent as whole venom.3. application of either whole venom (0.5-1.0 mg/ml) or the neurotoxic fraction (0.25-1.0 mg/ml) to the exposed cerebral cortex of the rat led to the appearance in the somatosensory evoked potential ... | 1970 | 5425281 |
| purification and some properties of toxin a from the venom of the indian cobra. | 1970 | 5447860 | |
| anesthetic deaths in cobras (naja naja and ophiophagus hannah) with methoxyflurane. | 1970 | 5465566 | |
| the amino acid sequence of cardiotoxin from formosan cobra (naja naja atra) venom. | 1970 | 5518165 | |
| phospholipase a of snake venoms. i. isolation and molecular properties of isoenzymes from naja naja and vipera russellii venoms. | 1971 | 5542003 |