Publications

potential of non-mulberry silk protein fibroin blended and grafted poly(є-caprolactone) nanofibrous matrices for in vivo bone regeneration.	an in vivo investigation is conducted to evaluate effectiveness of poly(є-caprolactone) (pcl) nanofibrous matrices, with non-mulberry silk fibroin (nsf) (from antheraea mylitta) inclusion, for bone tissue engineering. inclusion is achieved by either blending nsf with pcl prior to electrospinning substrates or by grafting nsf onto electrospun pcl substrates. proceeding from our previous in vitro results, showing that nsf grafted matrices have an edge when it comes to aiding cellular adhesion and ...	2016	27037780
reconstitution of the rna-dependent rna polymerase activity of antheraea mylitta cypovirus in vitro using separately expressed different functional domains of the enzyme.	antheraea mylitta cytoplasmic polyhedrosis virus is a segmented dsrna virus of the family reoviridae. segment 2 (s2)-encoded rna-dependent rna polymerase (rdrp) helps the virus to propagate its genome in the host cell of the silkworm, antheraea mylitta. cloning, expression, purification and functional analysis of individual domains of rdrp have demonstrated that the purified domains interact in vitro. the central polymerase domain (pd) shows nucleotide binding properties, but neither the n-termi ...	2016	27008451
non-mulberry silk fibroin grafted poly (є-caprolactone)/nano hydroxyapatite nanofibrous scaffold for dual growth factor delivery to promote bone regeneration.	this study aims at developing biodegradable, mineralized, nanofibrous scaffolds for use in bone regeneration. scaffolds are loaded with combinations of bone morphogenic protein-2 (rhbmp-2) and transforming growth factor beta (tgf-β) and evaluated in vitro for enhancement in osteoinductivity.	2016	26998786
generation of cytotoxic molecules and oxidative stress in haemolymph of pebrinised tasar silkworm antheraea mylitta drury.	the present study was carried out to investigate the effects of microsporidial infection on redox regulation mechanism and oxidative stress in tasar silkworm antheraea mylitta. high level of superoxide radical (p < 0.05), nitric oxide (p < 0.001) and lipid peroxidation (p < 0.001) was observed in haemolymph of pebrinised larvae, which indicated the resultant generation of cytotoxic molecules and oxidative damage. increased phenol oxidase (po) activity in haemolymph of pebrinised larvae indicated ...	2016	26930859
non-mulberry silk fibroin biomaterial for corneal regeneration.	successful repair of a damaged corneal surface is a great challenge and may require the use of a scaffold that supports cell growth and differentiation. amniotic membrane is currently used for this purpose, in spite of its limitations. a thin transparent silk fibroin film from non-mulberry antheraea mylitta (am) has been developed which offers to be a promising alternative. the silk scaffolds provide sufficient rigidity for easy handling, the scaffolds support the sprouting, migration, attachmen ...	2016	26908015
hydroxyapatite reinforced inherent rgd containing silk fibroin composite scaffolds: promising platform for bone tissue engineering.	replacement and repair of ectopic bone defects and traumatized bone tissues are done using porous scaffolds and composites. the prerequisites for such scaffolds include high mechanical strength, osseoconductivity and cytocompatibility. the present work is designed to address such requirements by fabricating a reinforced cytocompatible scaffold. biocompatible silk protein fibroin collected from tropical non-mulberry tasar silkworm (antheraea mylitta) is used to fabricate fibroin-hydroxyapatite (h ...	2017	28285159
fabrication and characterization of conductive conjugated polymer-coated antheraea mylitta silk fibroin fibers for biomedical applications.	conductive polymers are interesting materials for a number of biological and medical applications requiring electrical stimulation of cells or tissues. highly conductive polymers (polypyrrole and polyaniline)/antheraea mylitta silk fibroin coated fibers are fabricated successfully by in situ polymerization without any modification of the native silk fibroin. coated fibers characterized by scanning electron microscopy confirm the silk fiber surface is covered by conductive polymers. thermogravime ...	2017	28240813
elucidation of structural and functional integration of a novel antimicrobial peptide from antheraea mylitta.	we report here the amino acid sequence of an antimicrobial peptide of antheraea mylitta (peptide fraction ii) effectively killed urinary tract associated mdr e. coli (dutta et al., 2016), as gly-gly-gly-gly-gly-gly-his-leu-val-ala. the physicochemical and biological properties of this peptide were evaluated by computational analysis and its isoelectric point, grand average of hydropathicity and boman index values were found to be 6.74, 0.42 and -1.17kcal/mol, respectively. one valid model of pep ...	2017	28302399