| [dermatophytoses due to anthropophilic fungi in cadiz, spain, between 1997 and 2008]. | cutaneous fungal infections are a major public health problem. the distribution of the dermatophytoses varies between countries and geographical areas. the aim of this study was to determine the incidence, epidemiology, etiology, and clinical course of the dermatophytoses caused by anthropophilic fungi in cadiz, spain, over the past 12 years. | 2010 | 20398600 |
| evaluation of the association of superficial dermatophytosis and athletic activities with special reference to its prevention and control. | this study was conducted to evaluate the association of superficial mycosis and athletic activities with special references to its prevention and control in tehran. participating in various kinds of sports can lead to direct and indirect exposures to and transmission of micro-organisms between athletes and also passive observers. | 2010 | 20636349 |
| superficial fungal infections seen at a tertiary health centre: clinical and mycological studies. | superficial fungal infections are common in the tropics, partly due to the climate, relatively poor hygiene, and lifestyle of the people. | 2010 | 20931516 |
| clinicomicrobiological aspects of tinea cruris in madras. | a total of 242 patients with clinically diagnosed tinea cruris were screened and 181 (74.7 %) were found to be positive in culture for dermatophytes. 93.9% of infections were caused by trichophyton spp., of which 58.4% were trichophyton rubrum, 5.5% were epidermophyton floccosum, 3.8% were trichophyton tonsurans and we had a single isolate of microsporum gypseum complex. incidence of tinea cruris was higher in males (95.6%) than in females (4.4%). 45% of the cases were recurrent and 38% of cases ... | 1996 | 20948056 |
| elevation of antidermatophytic action of mefenamic acid by cobalt ions. | to evaluate the antifungal property of mefenamic acid, which is a member of non-steroidal anti-inflammatory drugs (nsaids) group. | 2010 | 21189903 |
| changes of dermatophytoses in southwestern greece: an 18-year survey. | the isolation and distribution rate of dermatophytes as causative agents of superficial mycoses of skin, hair, and nails during an 18-year period (1991-2008) at a university hospital are presented. a comparative analysis of epidemiological differences within the first (1991-1999) and the second 9-year period (2000-2008) was performed. skin scrapings, nail, and hair specimens were examined by a direct microscopic examination and culture. identification of dermatophyte species was based on macrosc ... | 2011 | 21331751 |
| activity of tdt 067 (terbinafine in transfersome) against agents of onychomycosis, as determined by minimum inhibitory and fungicidal concentrations. | tdt 067 is a novel carrier-based dosage form (liquid spray) of 15 mg/ml of terbinafine in transfersome that has been developed to deliver terbinafine to the nail bed to treat onychomycosis. in this study, we report the in vitro activities of tdt 067 against dermatophytes, compared with those of the transfersome vehicle, naked terbinafine, and commercially available terbinafine (1%) spray. the mics of tdt 067 and comparators against 25 clinical strains each of trichophyton rubrum, t. mentagrophyt ... | 2011 | 21411586 |
| some epidemiological aspects of dermatophyte infections in southwest iran. | distribution and prevalence of various species of dermatophytes are not the same in different areas of the world. the aim of the present study was epidemiologic evaluation of dermatophytic infections in our area. a retrospective epidemiologic study was carried out and all patients with dermatophyte positive smears identified at the referral center of southwest iran located in the city of ahvaz between march 2005 and march 2007 were investigated. body was divided into nine areas and information o ... | 2011 | 21489360 |
| melanogenesis in dermatophyte species in vitro and during infection. | dermatophytes are keratinophilic fungi that are the most common cause of fungal skin infections worldwide. melanin has been isolated from several important human fungal pathogens and the polymeric pigment is now recognized as an important virulence determinant. this study investigated whether dermatophytes, including trichophyton rubrum, t. mentagrophytes, epidermophyton floccosum, and microsporum gypseum, produce melanin or melanin-like compounds in vitro and during infection. digestion of the ... | 2011 | 21565930 |
| [fungal nail infections - an update : part 2 - from the causative agent to diagnosis - conventional and molecular procedures.] | trichophyton (t.) rubrum is the most frequently isolated dermatophyte in onychomycosis, both in germany and worldwide. t. interdigitale (formerly t. mentagrophytes var. interdigitale) follows in second place. a further however rarely isolated dermatophyte in onychomycosis is epidermophyton floccosum. candida parapsilosis, candida guilliermondii, and candida albicans, followed by trichosporon spp. are the most important yeasts which are found in onychomycosis. the molds most often responsible inc ... | 2011 | 22037818 |
| detection of antifungal compounds in polygonum ferrugineum wedd. extracts by bioassay-guided fractionation. some evidences of their mode of action. | polygonum ferrugineum wedd. (polygonaceae) is used to heal infected wounds and as antiseptic, antibiotic or antifungal in the traditional argentinean medicine. the present investigation was carried out to evaluate the antifungal properties of different extracts of aerial parts of polygonum ferrugineum, in order to give support to its ethnopharmacological use and to isolate the compounds responsible for the antifungal properties. the most active compounds were tested for their capacity of produci ... | 2011 | 22001591 |
| Chemical composition and biological activity of the volatile extracts of Achillea millefolium. | In this study, flowering aerial parts of wild Achillea millefolium growing on the Mediterranean coast (Sardinia Island, Italy) and on the Atlantic coast (Portugal- Serra de Montemuro) were used as a matrix for supercritical extraction of volatile oil with CO2 (SFE). The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of the essential oil isolated by hydrodistillation. A strong chemical variability in essential oils depending on the origi ... | 2011 | 22164800 |
| Antifungal activity and chemical composition of essential oils from Smyrnium olusatrum L. (Apiaceae) from Italy and Portugal. | The essential oils and supercritical CO(2) extracts of wild Smyrnium olusatrum L. growing in Sardinia (Italy) and in Portugal were investigated. For the study, oils were isolated from total plant aerial part (umbels containing seeds). The content of ß-phellandrene (67.3% vs. 42.7%) and a-pinene (31.9% vs. 1.2%), respectively, the main components of Portuguese and Italian essential oils, declined during the maturation stage of the umbels. Contrarily, some other important components, particularly ... | 2011 | 21902563 |
| Assessment of antimicrobial, insecticidal and genotoxic effects of Melia azedarach L. (chinaberry) naturalized in Anatolia. | In this study, antibacterial, antifungal, insecticidal and genotoxic activities of the fruit and leaf extracts of Melia azedarach of Turkish origin were evaluated for the first time. The antimicrobial activity was assessed against Gram (+) and ( - ) bacteria, four Candida species and three dermatophytic fungus (Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum). The insecticidal activity of the methanolic fruit extract was performed against the larvae of Aedes aegpyti, Culex ... | 2011 | 22149768 |
| design, synthesis and antifungal activity of some new imidazole and triazole derivatives. | triazole and imidazole are incorporated into the structures of many antifungal compounds. in this study a novel series of 1,2,4-triazole, imidazole, benzoimidazole, and benzotriazole derivatives was designed as inhibitors of cytochrome p450 14α-demethylase (14dm). these structures were docked into the active site of mt-cyp51, using autodock program. sixteen compounds with the best binding energy were synthesized. the chemical structures of the new compounds were confirmed by elemental and spectr ... | 2011 | 21984016 |
| sertaconazole nitrate shows fungicidal and fungistatic activity against trichophyton rubrum, trichophyton mentagrophytes, and epidermophyton floccosum, causative agents of tinea pedis. | the fungistatic and fungicidal activity of sertaconazole against dermatophytes was evaluated by testing 150 clinical isolates of causative agents of tinea pedis, trichophyton rubrum, trichophyton mentagrophytes, and epidermophyton floccosum. the overall geometric means for fungistatic and fungicidal activity of sertaconazole against these isolates were 0.26 and 2.26 µg/ml, respectively, though values were higher for t. mentagrophytes compared with the others. this is the first comprehensive demo ... | 2011 | 21746955 |
| chemical and biological diversity in fourteen selections of four ocimum species. | biomass, essential oil yield, essential oil composition diversity, and antibacterial and antifungal activities of 14 selections of 4 ocimum species [ocimum basilicum l. (selections: t1-t10), o. gratissimum l. (selections: t11-t12), o. tenuiflorum l.f., syn. o. sanctum l. (selection: t13) and o. kilimandscharicum baker ex. guerke (selection: t14)] were investigated. o. basilicum selections t9 (methyl chavicol: 87.0%) and t10 {(z)- and (e)-methyl cinnamate: 69.1%} produced higher biomass (67.8 and ... | 2011 | 22224293 |
| antifungal activity of aegle marmelos (l.) correa (rutaceae) leaf extract on dermatophytes. | to evaluate the in vitro antifungal activity of aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like trichophyton mentagrophytes, trichophyton rubrum, microsporum canis, microsporum gypseum and epidermophyton floccosum. | 2011 | 23569781 |
| prevalence of fungal skin infections in iranian wrestlers. | fungal infections are one of the most common skin infections. athletes, especially in contact sports such as wrestlers are the group at risk of fungal skin infections (fsi). the aim of this study was to determine prevalence of fsi and some effective factors in wrestlers in tehran, iran. | 2012 | 23785573 |
| anti-dermatophytic activity of marine sponge, sigmadocia carnosa (dendy) on clinically isolated fungi. | to screen the anti-fungal effects and find out the active metabolites from sponge, sigmadocia carnosa (s. carnosa) against four dermatophytic fungi. | 2012 | 23569985 |
| antimicrobial isothiocyanates from the seeds of moringa oleifera lam. | 4-(alpha-l-rhamnosyloxy)benzyl isothiocyanate (1) and 4-(4'-o-acetyl-alpha-l-rhamnosyloxy)-benzyl isothiocyanate (2) isolated from moringa oleifera seeds were screened for their antibacterial activities against staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, escherichia coli, enterobacter aerogenes, klebsiella pneumoniae, and pseudomonas aeruginosa, and for their antifungal activities against candida albicans, trichophyton rubrum, and epidermophyton floccosum using the disk ... | 2012 | 23413749 |
| antifungal activity of phlorotannins against dermatophytes and yeasts: approaches to the mechanism of action and influence on candida albicans virulence factor. | in the last few decades, fungal infections, particularly nosocomial, increased all around the world. this increment stimulated the search for new antifungal agents, especially those derived from nature. among natural products, those from marine sources have gained prominence in the last years. purified phlorotannins extracts from three brown seaweeds (cystoseira nodicaulis (withering) m. roberts, cystoseira usneoides (linnaeus) m. roberts and fucus spiralis linnaeus) were screened for their anti ... | 2013 | 23951297 |
| dermatophyte and non dermatophyte fungi in riyadh city, saudi arabia. | dermatophytes are a scientific label for a group of three genera (microsporum, epidermophyton and trichophyton) of fungus that causes skin disease in animals and humans. conventional methods for identification of these fungi are rapid and simple but are not accurate comparing to molecular methods. | 2015 | 26288566 |
| isolation of the volatile fraction from apium graveolens l. (apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity. | apium graveolens l. (wild celery), belonging to the family of apiaceae, is a scaposus hemicryptophyte. instead, the cultivate plant is an annual or biennial herb widely used as a spice and seasoning in food. a broad range of biological activities have been attributed to a. graveolens. these include antimicrobial activity, larvicidal activity, hepatoprotective activity, nematicidal and mosquito repellent potential and antihyperlipidaemic properties.in this study, the authors compare the compositi ... | 2013 | 22974401 |
| essential oil of juniperus communis subsp. alpina (suter) čelak needles: chemical composition, antifungal activity and cytotoxicity. | essential oils are known to possess antimicrobial activity against a wide spectrum of bacteria and fungi. in the present work the composition and the antifungal activity of the oils of juniperus communis subsp. alpina (suter) čelak were evaluated. moreover, the skin cytotoxicity, at concentrations showing significant antifungal activity, was also evaluated. the oils were isolated by hydrodistillation and analysed by gas chromatography and gas chromatography-mass spectrometry. minimal inhibitory ... | 2012 | 22294341 |
| nimesulide inhibits pathogenic fungi: pge2-dependent mechanisms. | certain non-steroidal anti-inflammatory drugs can inhibit fungal growth, fungal prostaglandin e2 production, and enzyme activation. this study aims to investigate the antifungal effect of nimesulide against pathogenic filamentous fungi and yeast. the experiments detailed below were also designed to investigate whether the action is dependent on e2 fungal prostaglandins. our data showed that nimesulide exhibited potent antifungal activity, mainly against trichophyton mentagrophytes (atcc 9533) an ... | 2017 | 27866353 |
| in vitro antifungal activity of some traditional persian medicinal plants on pathogenic fungi. | to investigate the antifungal activities of the extracts and sub-fractions of phlomis olivieri, verbascum speciosum, sambucus ebulus and erigeron hyrcanicus, four persian medicinal plants used in iranian folk medicine. | 2015 | 26129901 |
| antifungal activity of lactobacillus against microsporum canis, microsporum gypseum and epidermophyton floccosum. | a total of 220 lactic acid bacteria isolates were screened for antifungal activity using aspergillus fumigatus and aspergillus niger as the target strains. four lactobacillus strains exhibited strong inhibitory activity on agar surfaces. all four were also identified as having strong inhibitory activity against the human pathogenic fungi microsporum canis, microsporum gypseum and epidermophyton floccosum. one of the four lactobacilli, namely lb. reuteri ee1p exhibited the most inhibition against ... | 2017 | 22539027 |
| novel 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone isolated from terrestrial streptomyces sp. (eri-26) with antimicrobial and molecular docking studies. | streptomyces sp. isolate eri-26 was obtained from the nilgiris forest soil of western ghats, tamil nadu, india. novel anthraquinone compound was isolated from the active fraction 5; it was identified by spectroscopical data using uv, ir, nmr and mass. the isolated compound 1,5,7-trihydroxy-3-hydroxy methyl anthraquinone was tested against bacteria and fungi at minimum inhibitory concentration level. the compound showed significant antimicrobial activity against bacteria, staphylococcus aureus at ... | 2014 | 25149455 |
| antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, costus speciosus (koen ex.retz.) sm. | costus speciosus (koen ex.retz.) sm (costaceae) is an indian ornamental plant which has long been used medicinally in traditional systems of medicine. the plant has been found to possess diverse pharmacological activities. rhizomes are used to treat pneumonia, rheumatism, dropsy, urinary diseases, jaundice, skin diseases and leaves are used to treat mental disorders. | 2012 | 22397713 |
| sensitization and cross-reactions of dermatophyte and candida albicans allergens in patients with chronic urticaria. | chronic fungal infections are known to exacerbate allergic symptoms, including those of asthma and chronic urticaria (cu). we applied four prepared fungal antigens of trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, and candida albicans to examine sensitization to each in subjects with cu and onychomycosis and in healthy subjects, and to evaluate the etiologic role of dermatophytic infection in cu and observe any cross-reactions among these four antigens. | 2016 | 27420771 |
| superficial mycoses associated with diaper dermatitis. | diapers create particular conditions of moisture and friction, and with urine and feces come increased ph and irritating enzymes (lipases and proteases). fungi can take advantage of all these factors. candida yeasts, especially c. albicans, are responsible for the most frequent secondary infections and are isolated in more than 80 % of cases. correct diagnosis is important for ensuring the correct prescription of topical antimycotics. nystatin, imidazoles and ciclopirox are effective. it is impo ... | 2016 | 27193417 |
| sporicidal effect of amorolfine and other antimycotics used in the therapy of fungal nail infections. | although topical antifungal therapies for treating onychomycosis are available, the cure rate is unsatisfactorily low with a simultaneously high risk of recurrence. one reason might be the formation of dormant fungal cells by the pathogen, known as spores, which can survive in the affected nail keratin, thereby evading the effect of antifungal drugs. in this in vitro study, the ability of amorolfine and four other antimycotics (ciclopirox, bifonazole, terbinafine and fluconazole) to kill microco ... | 2015 | 26334024 |
| artemisia herba-alba essential oil from buseirah (south jordan): chemical characterization and assessment of safe antifungal and anti-inflammatory doses. | artemisia herba-alba asso ("desert wormwood" in english; "armoise blanche" in french; "shaih" in arabic), is a medicinal and strongly aromatic plant widely used in traditional medicine by many cultures since ancient times. it is used to treat inflammatory disorders (colds, coughing, bronchitis, diarrhea), infectious diseases (skin diseases, scabies, syphilis) and others (diabetes, neuralgias). in jordanian traditional medicine, this plant is used as antiseptic and against skin diseases, scabies, ... | 2015 | 26277492 |
| novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity. | a series of new triazole alcohol antifungals were designed by replacing one of the triazolyl moiety from fluconazole with a distinct 4-amino-3-mercapto-1,2,4-triazole motif, which is found in some antimicrobial agents. the antimicrobial susceptibility testing of target compounds demonstrated that the direct analogs of fluconazole (difluorophenethyl-triazoles) were less active against fungi, while compound 10h containing dichloro substitutions on both phenyl rings of the molecule had potent activ ... | 2015 | 25182365 |
| acyclic sesquiterpenes released by candida albicans inhibit growth of dermatophytes. | it is unresolved as to whether fungi that share a common skin habitat might in principal interact. in in vitro screening tests with candida albicans, trichophytum rubrum and other common dermatophytes, we found c. albicans releases volatile compounds that inhibit growth of the dermatophytes. by applying (enantioselective) gas chromatography combined with mass spectrometry we identified 8 compounds among which stereochemically pure (3r,6e)-2,3-dihydrofarnesol (r-dhf) and (2e,6e)-farnesol (f-ol) w ... | 2014 | 23902158 |
| onychomycosis: modern diagnostic and treatment approaches. | the medical term onychomycosis should be understood as chronic infection of the nails caused by a fungus. the most common causative agents are the dermatophytes and candida species. the less common are certain types of moulds (nondermatophyte moulds or ndms). in approximately 60-80 % of the cases, onychomycosis is due to dermatophytes. among dermatophytes, the most often isolated causative pathogen is trichophyton (t.) rubrum. other common species are t. interdigitale (formerly t. mentagrophytes ... | 2013 | 23053563 |
| antifungal activity of clove essential oil and its volatile vapour against dermatophytic fungi. | antifungal activities of clove essential oil and its volatile vapour against dermatophytic fungi including candida albicans, epidermophyton floccosum. microsporum audouinii, trichophyton mentagrophytes, and trichophyton rubrum were investigated. both clove essential oil and its volatile vapour strongly inhibit spore germination and mycelial growth of the dermatophytic fungi tested. the volatile vapour of clove essential oil showed fungistatic activity whereas direct application of clove essentia ... | 2007 | 24015106 |
| [superficial mycoses: casuistry of the mycology department of the instituto nacional de higiene "rafael rangel", caracas, venezuela (2001-2014)]. | the superficial mycoses are very common infectious diseases and therefore are a frequent reason for medical consultation. the aim of this study was to determine the diagnostic frequency of superficial mycoses in the mycology department of the instituto nacional de higiene "rafael rangel" during 14 years (2001-2014). a retrospective cross-sectional study was performed to review the mycological records of patients with presumptive diagnosis of superficial mycosis. nails, hairs and epidermal scales ... | 2016 | 27382801 |
| morphological and molecular identification of two strains of dermatophytes. | in this study, we used traditional morphological and molecular identification methods to preliminarily identify two strains of dermatophytes. the two strains were observed under the microscope. and then the dermatophytes were cultured on sabouraud's dextrose agar (sda). the 18s rrna regions of the two dermatophyte strains were amplified by polymerase chain reaction (pcr), and the pcr products were sequenced and compared with genbank data. blast tools and dnaman software were used to analyze the ... | 2013 | 24337859 |
| characterization of an endophytic whorl-forming streptomyces from catharanthus roseus stems producing polyene macrolide antibiotic. | an endophytic whorl-forming streptomyces sp. designated as ts3ro having antifungal activity against a large number of fungal pathogens, including sclerotinia sclerotiorum, rhizoctonia solani, colletotrichum gloeosporioides, cryphonectria parasitica, fusarium oxysporum, pyrenophora tritici-repentis, epidermophyton floccosum, and trichophyton rubrum, was isolated from surface-sterilized catharanthus roseus stems. preliminary identification showed that streptomyces cinnamoneus subsp. sparsus was it ... | 2012 | 22524528 |
| chemical characterisation and biological activity of leaf essential oils obtained from pistacia terebinthus growing wild in tunisia and sardinia island. | in the present work the chemical compositions, measured by gc and gc-ms, of the essential oils obtained by hydrodistillation from leaves of pistacia terebinthus collected in bizerte (tunisia) and baunei (italy) are reported. both essential oils possessed high content of monoterpene hydrocarbons (86.3% and 90.9%, respectively), being α-pinene (62.4 vs. 35.0)%, camphene (3.0 vs. 2.4)%, β-pinene (12.1 vs. 4.5)%, terpinolene (1.7 vs. 35.2)% and β-phellandrene (3.8 vs. 4.5)% the main components. the ... | 2017 | 28278668 |
| myrtus communis l. as source of a bioactive and safe essential oil. | in algeria, myrtus communis l. is distributed throughout the tell atlas and the coastal regions of algiers and constantine. the leaves are used in respiratory disorders, diarrhea and hemorrhoids. the aims of this work were to evaluate the antifungal and anti-inflammatory potential of well characterized essential oils (eo). since eo can be applied by inhalation, dermal application and oral administration, we used several mammalian cell lines to assess safe bioactive doses. the chemical compositio ... | 2015 | 25446467 |
| identification of dermatophilus congolensis from lower leg dermatitis of cattle in kerala, india. | this study was conducted to identify the aetiological agents associated with a particular type of lower leg dermatitis, locally called pododermatitis, among dairy cattle in kerala. skin scabs and scrapings were collected aseptically from 82 naturally occurring cases of lower leg dermatitis in cattle and were subjected to direct microscopical examination and bacterial and fungal culture. microscopical examination of the skin scrapings with 10% potassium hydroxide revealed fungal spores in hair sh ... | 2015 | 27044156 |
| enzymatic and non-enzymatic virulence activities of dermatophytes on solid media. | dermatophytes are keratinophilic fungi causing superficial cutaneous infections that account 20-25% of the global population. as per literature search, there is a dearth in the study on virulence factors of dermatophytes from the indian sub-continent and moreover the association of the virulence factors and the host tissue in vitro helps in understanding the host-pathogen interaction. | 2017 | 28384862 |
| antidermatophytic and protease-inhibiting activities of zerumbone: a natural sesquiterpene from the rhizome of zingiber zerumbet (l.) roscoe ex j.e; smith. | due to increase in the number of patients with impaired immunity, incidence of dermatophytoses has increased considerably. antidermatophytic agents with anti-inflammatory and protease-inhibiting activities will help in restricting inflammatory response associated with dermatophytoses. | 2017 | 28216875 |
| computational analysis of conserved coil functional residues in the mitochondrial genomic sequences of dermatophytes. | dermatophyte is a group of closely related fungi that have the capacity to invade keratinized tissue of humans and other animals. the infection known as dermatophytosis, caused by members of the genera microsporum, trichophyton, and epidermophyton includes infection to the groin (tinea cruris), beard (tinea barbae), scalp (tinea capitis), feet (tinea pedis), glabrous skin (tinea corporis), nail (tinea unguium), and hand (tinea manuum). the identification of evolutionary relationship between thes ... | 2016 | 28149055 |
| inhibition of dermatophytes by photodynamic treatment with curcumin. | treatment of dermatophytoses with currently available antimycotic agents is often tedious and sometimes unsatisfactory. a search for better therapeutic methods-ideally with an immediate fungicidal effect-has, among others, lead to photodynamic procedures as a promising alternative, and recently curcumin was found to be a suitable agent for this application. in this study the effect of photodynamic treatment with curcumin on dermatophytes was tested in vitro wells of microtiter plates were filled ... | 2017 | 28053148 |
| epidemiology of dermatophytoses in crete, greece. | dermatophytoses are among the most frequently diagnosed skin infections worldwide. however, the distribution of pathogenic species and the predominating anatomical sites of infection vary with geographical location and change over time. the aim of this study was to determine the epidemiological and aetiological factors of dermatophytoses in crete, greece over the last 5-year period (2011-2015) and their incidence in relation to the gender and the age of the patients. we compared our findings wit ... | 2016 | 27904054 |
| toward a novel multilocus phylogenetic taxonomy for the dermatophytes. | type and reference strains of members of the onygenalean family arthrodermataceae have been sequenced for rdna its and partial lsu, the ribosomal 60s protein, and fragments of β-tubulin and translation elongation factor 3. the resulting phylogenetic trees showed a large degree of correspondence, and topologies matched those of earlier published phylogenies demonstrating that the phylogenetic representation of dermatophytes and dermatophyte-like fungi has reached an acceptable level of stability. ... | 2017 | 27783317 |
| the changing face of dermatophytic infections worldwide. | dermatophytes evolve along with the geography and socioeconomic conditions. epidermophyton floccosum, microsporum audouinii and trichophyton schoenleinii acted as the major pathogens of superficial fungal diseases 100 years ago, but their frequency decreased dramatically since the middle of the twentieth century and they are limited to some less-developed countries nowadays; meanwhile, frequency of trichophyton rubrum, trichophyton interdigitale, trichophyton tonsurans and microsporum canis incr ... | 2017 | 27783316 |
| antidermatophytic action of resorcinol derivatives: ultrastructural evidence of the activity of phenylethyl resorcinol against microsporum gypseum. | in this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. the antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatom ... | 2016 | 27706019 |
| econazole nitrate foam 1% improves the itch of tinea pedis. | econazole nitrate topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by <em>trichophyton rubrum, trichophyton mentagrophytes,</em> and <em>epidermophyton floccosum</em> in patients 12 years of age and older. the symptom of itch or pruritus was evaluated in two randomized, double-blind, parallel-group, vehicle-controlled, multicenter phase iii studies in which econazole foam was compared with foam vehicle in subjects with interdigital tinea pedis. a thin, uniform ... | 2016 | 27602974 |
| epidemiological trends of dermatophytosis in tehran, iran: a five-year retrospective study. | dermatophytosis is the most frequent fungal infection all over the world and its frequency is constantly increasing. the aim of this study was to evaluate clinical features and epidemiological trends of dermatophytosis over the years 2010 to 2014 in tehran, iran. | 2016 | 27520535 |
| characterization of clinically important dermatophytes in north of iran using pcr-rflp on its region. | dermatophytosis is considered as one of the major public health problems in the world. accurate identification of the dermatophytes species is important for recognition of the environment and animal sources of infection. in this survey, 1500 clinical specimens taken from outpatients suspected of dermatophytosis and they were examined by direct microscopy and culture. | 2016 | 27496524 |
| antidermatophytic activity of ethanolic extract from croton tiglium. | dermatophytosis, which is caused mainly by genera of trichophyton, epidermophyton, and microsporum, is a frequent dermatological problem in tropical and subtropical countries. investigations were carried out in this study to evaluate the antidermatophytic activity of the stems, leaves, and seeds of croton tiglium, one of the traditional medicine plants indigenous to asia. ethanolic extracts of the stems, leaves, and seeds of c. tiglium were prepared by cold soak or heat reflux methods. the antid ... | 2016 | 27446946 |
| molecular identification and phylogenetical analysis of dermatophyte fungi from latin america. | dermatophytes constitute a complex group of fungi, comprised of by the genera trichophyton, epidermophyton and microsporum. they have the ability to degrade keratin and cause human and animal infections. molecular techniques have made their identification faster and more accurate, and allowed important advances in phylogenetic studies. we aim to identify molecularly and to determine the phylogenetic relationships in dermatophyte fungi from brazil and other latin american countries, using dna seq ... | 2016 | 27432316 |
| preparation and physicochemical characterization of topical chitosan-based film containing griseofulvin-loaded liposomes. | griseofulvin is an antifungal drug and is available as oral dosage forms. development of topical treatment could be advantageous for superficial fungal infections of the skin. in this study, films prepared from the incorporation of griseofulvin-loaded liposomes in chitosan film for topical drug delivery in superficial fungal infections. the properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior, and antifung ... | 2017 | 27429928 |
| evaluation of incubation time for dermatophytes cultures. | in general, it is recommended to incubate dermatophytes cultures for a minimum of 4 weeks. several aspects of routine fungal cultures should be evaluated in order to implement appropriate and necessary changes. the aim of this study was to determine the optimum incubation time for routine dermatophytes cultures, analysing the time to find first fungal growth by visual observation. we recorded the time when the initial growth was detected for all dermatophyte isolates during a 4-year period. a to ... | 2016 | 27144472 |
| antifungal susceptibility and virulence factors of clinically isolated dermatophytes in tehran, iran. | dermatophytes possess a wide array of virulence factors and various antifungal susceptibility patterns which influence their pathogenesis in humans and animals. the aim of this study was to evaluate antifungal susceptibility and keratinase and proteinase activity of 49 dermatophyte strains from the genera microsporum, trichophyton and epidermophyton which were isolated from human cases of dermatophytosis. | 2016 | 27092223 |
| epidemiological aspects of dermatophytosis in khuzestan, southwestern iran, an update. | dermatophytosis is among the most common superficial mycoses in iran. the purpose of this report was to update the clinical and mycological features of human dermatophytosis in the khuzestan, southwestern iran. in the framework of a one-year survey, a total of 4120 skin, hair and nail samples obtained from the outpatients with symptoms suggestive of tinea were analyzed by using direct microscopy, culture and molecular identification methods. strains isolated from cultures were subjected to ampli ... | 2016 | 26886443 |
| phylogenetic analysis of dermatophyte species using dna sequence polymorphism in calmodulin gene. | use of phylogenetic species concepts based on rdna internal transcribe spacer (its) regions have improved the taxonomy of dermatophyte species; however, confirmation and refinement using other genes are needed. since the calmodulin gene has not been systematically used in dermatophyte taxonomy, we evaluated its intra- and interspecies sequence variation as well as its application in identification, phylogenetic analysis, and taxonomy of 202 strains of 29 dermatophyte species. a set of primers wa ... | 2016 | 26868901 |
| multilaboratory evaluation of in vitro antifungal susceptibility testing of dermatophytes for me1111. | me1111 is a novel small molecule antifungal agent under development for the topical treatment of onychomycosis. standardization of the susceptibility testing method for this candidate antifungal is needed. toward this end, 8 independent laboratories determined the interlaboratory reproducibility of me1111 susceptibility testing. in addition, we subsequently identified 2 strains as quality control (qc) isolates for the method. in the reproducibility study, 5 blinded clinical strains each of trich ... | 2016 | 26719434 |
| pattern of dermatophytes in patients attend in mymensingh medical college hospital. | dermatophytosis is a common fungal disease which involves the keratinized tissue. this is an attempt to observe the spectrum of dermatophytes among the clinically suspected cases of dermatophytosis attending the outpatient department of dermatology and venereology, mymensingh medical college hospital, mymensingh during the period of july 2013 to december 2014. two hundred thirty (230) clinically suspected cases of dermatophytosis were subjected in this study. sixty three cases (27.39%) were posi ... | 2015 | 26620004 |
| [2011 epidemiological survey of dermatomycoses in japan]. | an epidemiological survey of dermatomycoses and their causative fungus flora in japan for 2011 was conducted in accordance with methods and criteria of the past four surveys. the survey covered a total number of 36,052 outpatients who visited 12 dermatological clinics throughout japan. the results were as follows. 1）dermatophytosis was the most prevalent cutaneous fungal infection (2,980 cases) seen in these clinics, followed by candidiasis (378 cases) and then malassezia infections (152 cases). ... | 2015 | 26617109 |
| species identification of dermatophytes in paraffin-embedded biopsies with a new polymerase chain reaction assay targeting the internal transcribed spacer 2 region and comparison with histopathological features. | dermatophytosis is a very common skin infection with a broad clinical spectrum. biopsies are often used to confirm the diagnosis, especially when the clinical presentation is unusual. not uncommonly, organisms are hard to find even with periodic acid-schiff stains. polymerase chain reaction (pcr) for dermatophytes can be used in such cases. | 2016 | 26556042 |
| induction by epidermophyton floccosum of human fibroblast matrix metalloproteinase-9 secretion in vitro. | skin infection from pathogenic dermatophyte, epidermophytonfloccosum, can cause serious health complications, especially in immuno-compromised patients. proteolytic enzymes secreted from e. floccosum are required for host tissue degradation, facilitating fungal invasion. however, little is known regarding host matrix metalloproteinase (mmp) expression during e. floccosum infection. in this study human foreskin fibroblast (hff) cell line was used to determine mmp-9 protease activity by gelatin zy ... | 2015 | 26513930 |
| epidemiology of tinea capitis in northeast iran: a retrospective analysis from 1998 to 2012. | tinea capitis is a common disease of the pediatric population. this disease typically follows one of several clinical patterns, i.e., scaling, hair loss, and/or inflammatory lesions, which are usually caused predominantly by two dermatophytic genera: microsporum and trichophyton. the aim of this study was to investigate tinea capitis and its etiological agents in sari city of mazandaran province, iran. | 2016 | 26440755 |
| detection of common dermatophytes in clinical specimens using a simple quantitative real-time taqman polymerase chain reaction assay. | dermatophytes are common fungal pathogens causing mostly superficial infections in humans with a high prevalence worldwide. traditional detection techniques are time-consuming and insensitive, whereas molecular detection methods have proved to be much more rapid and sensitive. | 2016 | 26406273 |
| molecular characterization and in vitro antifungal susceptibility of 316 clinical isolates of dermatophytes in iran. | dermatophytosis is a common mycotic infection of the skin, nail, and hair, associated with major public health concern worldwide. various species of dermatophytes show significant differences in susceptibility to antifungals. here, we present the antifungal susceptibility of a large collection of molecularly identified dermatophyte isolates obtained from tropical region of south of iran. a total of 9485 patients clinically suspected to have cutaneous fungal infections were examined. dermatophyto ... | 2016 | 26369643 |
| dermatophytosis: a 16-year retrospective study in a metropolitan area in southern brazil. | dermatophytoses are considered a public health problem. the objectives of this study were to determine the evolution of their prevalence in the metropolitan area of porto alegre, brazil, and to analyze the dermatophyte species distribution according to body site and demographic characteristics of the patients. | 2015 | 26322879 |
| use of restriction fragment length polymorphism to rapidly identify dermatophyte species related to dermatophytosis. | dermatophytes are a group of keratinophilic fungi worldwide, which can infect the skin, hair and nails of humans and animals. this genus includes several species that present different features of dermatophytosis. although, laboratory diagnosis of dermatophytes is based on direct microscopy, biochemical tests and culture, these manners are expensive, time consuming and need skilled staff. therefore, molecular methods like pcr-rflp are the beneficial tools for identification, which are rapid and ... | 2015 | 26301058 |
| inhibitory effect of silver nanoparticles mediated by atmospheric pressure air cold plasma jet against dermatophyte fungi. | in an in vitro study with five clinical isolates of dermatophytes, the mic(50) and mic(100) values of silver nanoparticles (agnps) ranged from 5 to 16 and from 15 to 32 μg ml(- 1), respectively. the combined treatment of agnps with atmospheric pressure-air cold plasma (apacp) induced a drop in the mic(50) and mic100 values of agnps reaching 3-11 and 12-23 μg ml(- 1), respectively, according to the examined species. epidermophyton floccosum was the most sensitive fungus to agnps, while trichophyt ... | 2015 | 26296782 |
| a multi-target approach toward the development of novel candidates for antidermatophytic activity: ultrastructural evidence on α-bisabolol-treated microsporum gypseum. | multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. the antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: mi ... | 2015 | 26132903 |
| antidermatophytic activity of mikania micrantha kunth: an invasive weed. | the incidence of dermatophytosis has risen dramatically in recent years. limited availability of side-effect free drugs has led to a search for new antidermatophytic agents. | 2015 | 26109783 |
| anti-dermatophyte efficacy and environmental safety of some essential oils commercial and in vitro extracted pure and combined against four keratinophilic pathogenic fungi. | establish new biocontrol practices with low persistence in the environment against dermatophyte causing mycosis. | 2015 | 25953414 |
| a 10-year study of dermatophytoses in isfahan, iran. | dermatophyte infections are very common worldwide and their epidemiological characteristics vary according to the geographical region and have altered in the last decades. the aim of the present investigation was to determine the diversity of causative agents of dermatophytoses and describe the epidemiological condition of infection in isfahan, iran, between 2003 and 2012. specimens were collected from hair, nail, and skin and were examined by conventional methods such as direct microscopy, cult ... | 2016 | 25902908 |
| isolation of dermatophytes (and other fungi) from human nail and skin dust produced by podiatric medical treatments in australia. | podiatric physicians routinely use electric drills for the treatment of nail and skin conditions. the grinding process produces human nail and skin dust that is generally vacuumed into bags in the grinding unit. many of the nails are thought to be mycotic, particularly because they are obtained from patients with symptoms of dermatophyte infections. currently, there is limited information available on the detection of fungi from nail dust samples. herein, we attempt to address this situation and ... | 2015 | 25815649 |
| in vitro susceptibility patterns of clinically important trichophyton and epidermophyton species against nine antifungal drugs. | despite the common, worldwide, occurrence of dermatophytes, little information is available regarding susceptibility profiles against currently available and novel antifungal agents. a collection of sixty-eight clinical trichophyton species and epidermophyton floccosum were previously identified and verified to the species level by sequencing the internal transcribed spacer (its) regions of rdna. mics of amphotericin b, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, terbin ... | 2015 | 25757042 |
| onychomycosis in north-east of iran. | onychomycosis is a common fungal infection which has been conducted in many parts of the world. the aim of this study was to evaluate the epidemiology and to identify the aetiological factors of onychomycosis in mazandaran province, iran. | 2014 | 25705360 |
| isolation of dermatophytes (and other fungi) from human nail and skin dust produced by podiatric medical treatments in australia. | background: podiatric physicians routinely use electric drills for the treatment of nail and skin conditions. the grinding process produces human nail and skin dust that is generally vacuumed into bags in the grinding unit. many of the nails are thought to be mycotic, particularly because they are obtained from patients with symptoms of dermatophyte infections. currently, there is limited information available on the detection of fungi from nail dust samples. herein, we attempt to address this s ... | 2015 | 25647477 |
| antimicrobial and antioxidant activities and chemical characterization of essential oils of thymusvulgaris, rosmarinus officinalis, and origanum majorana from northeastern méxico. | there have been no reports of antifungal activity and composition of extracts from thymus vulgaris, rosmarinus officinalis or origanum majorana from northeastern méxico. antifungal activity of these oils against trichophyton rubrum, trichophyton tonsurans, trichophyton mentagrophytes, microsporum gypseum, microsporum canis and epidermophyton floccosum was measured by diffusion assay. additionally, antibacterial and antioxidant activities were evaluated. antibacterial activity against staphylococ ... | 2015 | 25631514 |
| investigation of in vitro activity of five antifungal drugs against dermatophytes species isolated from clinical samples using the e-test method. | dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. although there are increasing numbers of antifungals available for treatment of dermatophytes, some cases and relapses have been unresponsive to treatment. the determination of fungus in-vitro antifungal susceptibility has been reported to be important for the ability ... | 2014 | 25610290 |
| translation elongation factor 1-α gene as a potential taxonomic and identification marker in dermatophytes. | intra- and interspecies variations of the translation elongation factor 1-α (tef-1α) gene were evaluated as a new identification marker in a wide range of dermatophytes, which included 167 strains of 30 species. an optimized pan-dermatophyte primer pair was designed, and the target was sequenced. consensus sequences were used for multiple alignment and phylogenetic tree analysis and the levels of intra- and interspecific nucleotide polymorphism were assessed. between species, the analyzed part o ... | 2015 | 25550390 |
| hemolytic activity of dermatophytes species isolated from clinical specimens. | hemolytic activity was recently reported for several pathogenic fungal species, such as aspergillus, candida, trichophyton, penicillium and fusarium. based on a number of mechanistic and characterization studies, several fungal hemolysins have been proposed as virulence factors. hemolysins lyse red blood cells resulting in the release of iron, an important growth factor for microbes especially during infection. the requirement of iron in fungal growth is necessary for metabolic processes and as ... | 2015 | 25467819 |
| an ancient plant lawsonia inermis (henna): determination of in vitro antifungal activity against dermatophytes species. | world is endowed with a rich wealth of medicinal plants. there is a widespread belief that green medicines are healthier and more harmless or safer than synthetic ones. medicinal plants have been used to cure a number of diseases. the ancient plant lawsonia inermis or henna is used as medicinal plant because of its attributed strong fungicidal, anti-inflammatory, analgesic, antibacterial, virucidal, antiparasitic, antiamoebiasis, astringent, antihemorrhagic, hypotensive, sedative, anticancer eff ... | 2014 | 25442917 |
| chemical analysis and in vitro antiviral and antifungal activities of essential oils from glechon spathulata and glechon marifolia. | glechon spathulata benth. and glechon marifolia benth. (lamiaceae, mentheae) are aromatic plants used in traditional medicine for the treatment of viral infections. | 2015 | 25431185 |
| cutaneous bacterial species from lithobates catesbeianus can inhibit pathogenic dermatophytes. | antibiotics are being successfully used to fight many infectious diseases caused by pathogenic microorganisms. however, new infectious diseases are continuously being identified, and some known pathogens are becoming resistant against known antibiotics. furthermore, many antifungals are causing serious side effects in long-term treatments of patients, and many skin infections caused by dermatophytes are difficult to cure. the beneficial roles of resident cutaneous microbiota to inhibit pathogeni ... | 2015 | 25431089 |
| application of pcr fingerprinting using (gaca)4 primer in the rapid discrimination of dermatophytes. | superficial fungal infections have a major impact on cosmetic health, affecting more than 20-25% of the global population, which is predominantly caused by dermatophytes. as per literature search, molecular strain typing of dermatophytes has not been investigated in india. therefore, the present study was carried out to characterise the dermatophyte species and strains by molecular methods. | 2015 | 25008813 |
| mycological pattern of dermatophytosis in and around shimla hills. | dermatophytosis is defined as the fungal infection of the skin, hair and nails by a group of keratinophillic fungi known as dermatophytes. | 2014 | 24891658 |
| tinea pedis: the etiology and global epidemiology of a common fungal infection. | tinea pedis, which is a dermatophytic infection of the feet, can involve the interdigital web spaces or the sides of the feet and may be a chronic or recurring condition. the most common etiological agents are anthropophiles, including trichophyton rubrum sensu stricto, which is the most common, followed by trichophyton interdigitale and epidermophyton floccosum. there has been a change in this research arena, necessitating a re-evaluation of our knowledge on the topic from a multidisciplinary p ... | 2015 | 24495093 |
| characterization of a new sesquiterpene and antifungal activities of chemical constituents from dryopteris fragrans (l.) schott. | one new sesquiterpene and six known compounds were isolated from dryopteris fragrans (l.) schot. they were identified as 3-o-β-d-glucopyranosylalbicanol- 11-o-β-d-glucopyranoside (1), dihydroconiferylalcohol (2), (e)-3-(4-hydroxyphenyl)acrylic acid (3), esculetin (4), 5,7-dihydroxy-2-hydroxymethylchromone (5), eriodictyol (6) and isoorientin (7) by uv, ms, 1d-nmr and 2d-nmr spectroscopy. the antifungal activities of the seven isolated compounds were screened. compounds 2, 3, 4 and 5 showed obvio ... | 2014 | 24451246 |
| [taxonomic study of clinic isolates of trichophyton in rosario, argentina]. | due to the pleomorphism and cultural variability displayed by species of the genus trichophyton, the identification methods based solely on morphological features are usually insufficient for their classification. the goal of the present work was to test a set of phenotypic methods in order to identify fungal isolates that belong to the aforementioned genus. these methods were based on a molecular taxonomic technique used as standard. clinical isolates (56) were used as samples along with 6 refe ... | 2014 | 24401778 |
| in vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes. | to investigate the antifungal drug susceptibility of fungi responsible for dermatomycoses, minimum inhibition concentration (mic) tests were performed in 44 strains of dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton verrucosum, trichophyton tonsurans, microsporum canis, microsporum gypseum and epidermophyton floccosum, with six antifungal drugs (amorolfine, terbinafine, butenafine, ketoconazole, itraconazole and bifonazole) by broth microdilution assay acc ... | 2014 | 24215461 |
| in vitro activities of antifungal drugs against dermatophytes isolated in tokat, turkey. | in this study, we aimed to establish the in vitro antifungal susceptibilities of terbinafine, miconazole, itraconazole, ketoconazole, griseofulvin, and amphotericin b against dermatophyte isolates. | 2013 | 24134487 |
| efficacy of some synthesized thiazoles against dermatophytes. | twelve thiazoles and their fused derivatives were tested for their antimicrobial activity against trichophyton rubrum, t. terrestre, epidermophyton floccosum, and microsporum gypseum. most of the synthesized compounds were inhibitory to the tested fungi. the most effective compound was 5-(4-ethoxybenzylidene-4,5-dihydro-4-oxothiazol-2-yl)-n,3-diphenylbut-2-namide (3c) followed by 2-(4-oxo-4,5-dihydrothiazol-2-yl)-3-phenyl-but-2-enoic acid-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-amide ( ... | 2013 | 24129248 |
| inactivation of pathogenic dermatophytes by ultraviolet irradiation in swimming pool thermal water. | the effect of ultraviolet (uv) radiation from low-pressure mercury lamp against some pathogenic dermatophytes species such as epidermophyton floccosum, trichophyton mentagrophytes, trichophyton rubrum, trichophyton schoenleinii, trichophyton tonsurans and trichophyton violaceum suspended in thermal water was evaluated in laboratory-scale condition at various times. the main results showed that within 120 s of exposure, all species of dermatophytes are completely inactivated, which was evidenced ... | 2014 | 24024625 |
| a molecular epidemiological survey of clinically important dermatophytes in iran based on specific rflp profiles of beta-tubulin gene. | surveillance of dermatophytosis is essential to determine the likely changes in etiological trends and distribution profile of this infection. in this study beta tubulin gene (bt2), was used as the first time in a pcr-rflp format to clarify the distribution of dermatophytosis agents in some parts of iran. | 2013 | 26060667 |
| surveillance of dermatophytosis in northeast of iran (mashhad) and review of published studies. | dermatophytoses are considered to be one of the major public health problems in the world and are among the most commonly diagnosed skin diseases in iran. in spite of improved personal hygiene and living environment, dermatophytosis continues to spread and persist. to determine the prevalence of dermatophytosis and their etiologic agents in mashhad (iran), five hundred and sixty patients suspected to have fungal infection were studied. subjects who participated in this study were 330 males and 2 ... | 2013 | 23943426 |
| treatment of onychomycosis using a submillisecond 1064-nm neodymium:yttrium-aluminum-garnet laser. | laser treatment has emerged as a novel treatment modality for onychomycosis. | 2013 | 23856649 |