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evaluation of disease modifying activity of coriandrum sativum in experimental models.coriandrum sativum (cs), has been widely used in traditional systems of medicine for treatment of rheumatoid arthritis. however, the mechanism of action for its antiarthritic effects is not clearly known. therefore, the present study was carried out to evaluate the antiarthritic activity of cs in rats in two experimental models.022446868
17(r)-resolvin d1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception.transient receptor potential ion channel vanilloid 3 (trpv3) is expressed in skin keratinocytes and plays an important role in thermal and chemical nociceptions in the periphery. the presence of trpv3 inhibitors would improve our understanding of trpv3 function and help to develop receptor-specific analgesics. however, little is known about physiological substances that specifically inhibit trpv3 activity. here, we investigated whether 17(r)-resolvin d1 (17r-rvd1), a naturally occurring pro-reso ...021718307
antigen-specific therapeutic approaches in type 1 diabetes.development of strategies capable of specifically curbing pathogenic autoimmune responses in a disease- and organ-specific manner without impairing foreign or tumor antigen-specific immune responses represents a long sought-after goal in autoimmune disease research. unfortunately, our current understanding of the intricate details of the different autoimmune diseases that affect mankind, including type 1 diabetes, is rudimentary. as a result, progress in the development of the so-called "antigen ...022355799
psychometric properties of the iranian version of resources and support for chronic illness self-management scale in patients with type 2 diabetes.this article is a report of psychometric testing of the farsi version of resources and support for chronic illness self-management (rssm) scale.022347603
a multiple-group path analysis of the role of everyday discrimination on self-rated physical health among latina/os in the usa.few studies have examined the psychosocial mechanisms through which self-reported discrimination may influence the health status of latinos.023054945
evidence for a multi-dimensional latent structural model of externalizing disorders.strong associations between conduct disorder (cd), antisocial personality disorder (aspd) and substance use disorders (sud) seem to reflect a general vulnerability to externalizing behaviors. recent studies have characterized this vulnerability on a continuous scale, rather than as distinct categories, suggesting that the revision of the diagnostic and statistical manual of mental disorders (dsm-5) take into account the underlying continuum of externalizing behaviors. however, most of this resea ...022936218
chronic pain: emerging evidence for the involvement of epigenetics.epigenetic processes, such as histone modifications and dna methylation, have been associated with many neural functions including synaptic plasticity, learning, and memory. here, we critically examine emerging evidence linking epigenetic mechanisms to the development or maintenance of chronic pain states. although in its infancy, research in this area potentially unifies several pathophysiological processes underpinning abnormal pain processing and opens up a different avenue for the developmen ...022325197
applying ecodevelopmental theory and the theory of reasoned action to understand hiv risk behaviors among hispanic adolescents.hiv/aids is listed as one of the top 10 reasons for the death of hispanics between the ages of 15 and 54 in the united states. this cross sectional, descriptive secondary study proposed that using both the systemic (ecodevelopmental) and the individually focused (theory of reasoned action) theories together would lead to an increased understanding of the risk and protective factors that influence hiv risk behaviors in this population. the sample consisted of 493 hispanic adolescent 7th and 8th g ...023152718
pkcα is required for inflammation-induced trafficking of extrasynaptic ampa receptors in tonically firing lamina ii dorsal horn neurons during the maintenance of persistent inflammatory pain.persistent inflammation promotes internalization of synaptic glur2-containing, ca(2+)-impermeable ampa receptors (ampars) and insertion of glur1-containing, ca(2+)-permeable ampars at extrasynaptic sites in dorsal horn neurons. previously we have shown that internalization of synaptic glur2-containing ampars requires activation of spinal cord protein kinase c alpha (pkcα), but molecular mechanisms that underlie altered trafficking of extrasynaptic ampars are unclear. here, using antisense (as) o ...023374940
lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis.experimental autoimmune encephalomyelitis (eae) is a commonly-used animal model of the human demyelinating disease, multiple sclerosis (ms). similar to ms, eae is under genetic control in that certain mouse strains are susceptible to disease induction with myelin antigens, while other strains are resistant. in the past, major efforts studying eae tended to focus on the mechanism of disease susceptibility pertaining to antigen specificities, disease progression and related cytokines. the basis of ...024795508
decoupling of tumor-initiating activity from stable immunophenotype in hoxa9-meis1-driven aml.increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. in a hoxa9-meis1 (h9m) model of acute myeloid leukemia (aml), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages on the normal hematopoietic hierarchy--stem/progenitor cells (lin(-)kit(+)) and committed progenitors of the myeloid (gr1(+)kit(+)) and lymphoid lineages (lym(+)kit(+)). these distin ...022305570
the genetics of canine skull shape variation.a dog's craniofacial diversity is the result of continual human intervention in natural selection, a process that began tens of thousands of years ago. to date, we know little of the genetic underpinnings and developmental mechanisms that make dog skulls so morphologically plastic. in this perspectives, we discuss the origins of dog skull shapes in terms of history and biology and highlight recent advances in understanding the genetics of canine skull shapes. of particular interest are those mol ...023396475
therapeutic effect of cytotoxic t lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis.collectively, the data in both humans and murine models of human primary biliary cirrhosis (pbc) suggest that activated t cells, particularly cd8 t cells, play a critical role in biliary cell destruction. under physiological conditions, t-cell activation involves two critical signals that involve the major histocompatibility complex and a set of costimulatory molecules, which include a receptor on t cells termed cytotoxic t lymphocyte antigen 4 (ctla-4). germane to the studies reported herein, s ...022996325
integrating validity theory with use of measurement instruments in clinical settings.to present validity concepts in a conceptual framework useful for research in clinical settings.016178998
convergent and discriminant validity of psychopathy factors assessed via self-report: a comparison of three instruments.psychopathy has been conceptualized as a personality disorder with distinctive interpersonal-affective and behavioral deviance features. the authors examine correlates of the factors of the psychopathic personality inventory (ppi), self-report psychopathy-ii (srp-ii) scale, and antisocial process screening device (apsd) to understand similarities and differences among the constructs embodied in these instruments. ppi fearless dominance and srp-ii factor 1 were negatively related to most personal ...016123248
differentiation of reactive and tumor metastatic lymph nodes with diffusion-weighted and spio-enhanced mri.determination of lymphatic metastasis is of great importance for both treatment planning and patient prognosis. we aim to distinguish tumor metastatic lymph nodes (tlns) and reactive lymph nodes (rlns) with diffusion-weighted and superparamagnetic iron oxide (spio)-enhanced magnetic resonance imaging (mri).022588595
dance is the new metal: adolescent music preferences and substance use across europe.this study examined relationships between music preferences and substance use (tobacco, alcohol, cannabis) among 18,103 fifteen-year-olds from 10 european countries. in 2005-2006, across europe, preferences for mainstream pop (pop chart music) and highbrow (classical music and jazz) were negatively associated with substance use, while preferences for dance (house/trance and techno/hardhouse) were associated positively with substance use. in three countries, links were identified between liking r ...022217067
correlation between arterial fdg uptake and biomarkers in peripheral artery disease.a prospective, multicenter (18)fluorine-fluorodeoxyglucose ((18)f-fdg) positron emission tomography (pet)/computed tomography (ct) imaging study was performed to estimate the correlations among arterial fdg uptake and atherosclerotic plaque biomarkers in patients with peripheral artery disease.022239891
diagnosing malabsorption with systemic lipid profiling: pharmacokinetics of pentadecanoic acid and triheptadecanoic acid following oral administration in healthy subjects and subjects with cystic fibrosis.a malabsorption blood test (mbt) is proposed as an alternative method to the 72-hour stool and dietary collection for assessing the degree of fat malabsorption in people with pancreatic insufficiency. the mbt consists of a simultaneous oral dose of pentadecanoic acid (pa), a free fatty acid, and triheptadecanoic acid (tha), a triglyceride with three heptadecanoic (ha) saturated fatty acids requiring hydrolysis by pancreatic lipase before ha can be intestinally absorbed. the aim of this study is ...023357842
maternal role confusion: relations to maternal attachment and mother-child interaction from infancy to adolescence.self-reports of role confusion with the parent in childhood are associated with a variety of adverse outcomes. however, role-confusion has been studied primarily from the point of view of the child. the current study evaluated an instrument for assessing role confusion from maternal interviews rather than from child observations or self-reports in adulthood. fifty-one mothers participating in a longitudinal study since their own child's infancy were administered the experiences of caregiving int ...025544789
measuring social support from mother-figures in the transition from pregnancy to parenthood among mexican-origin adolescent mothers.social support for adolescent mothers, particularly from mother figures, can buffer risks and promote well-being. to date, no longitudinal research has investigated how the dimensions of social support may change during the transition from pregnancy to parenthood for adolescent mothers. this study examined stability and change in dimensions of social support from the third trimester of pregnancy to two years postpartum among 191 dyads of mexican-origin adolescent first-time mothers and their mot ...023729988
biotech takes on the obesity challenge.success with weight-loss treatments has been mostly elusive for large pharmaceutical companies. now the biotech industry is stepping forward, eager to contribute to an area that carries with it the potential for explosive growth.023393462
mismatch of posttraumatic stress disorder (ptsd) symptoms and dsm-iv symptom clusters in a cancer sample: exploratory factor analysis of the ptsd checklist-civilian version.the diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv; american psychiatric association, 1994a) conceptualization of posttraumatic stress disorder (ptsd) includes three symptom clusters: reexperiencing, avoidance/numbing, and arousal. the ptsd checklist-civilian version (pcl-c) corresponds to the dsm-iv ptsd symptoms. in the current study, we conducted exploratory factor analysis (efa) of the pcl-c with two aims: (a) to examine whether the pcl-c evidenced the three-fa ...016281232
camp for all connection: a community health information outreach project.the purpose of the camp for all connection project is to facilitate access to electronic health information resources at the camp for all facility.016059424
evaluating the effect of translation on spanish speakers' ratings of medicare.this study examined the equivalence of the english and spanish versions of the medicare consumer assessment of health plans study (cahps) fee-for-service (ffs) survey among 2,996 hispanic medicare beneficiaries. multigroup confirmatory factor analyses indicated that with few exceptions the factor structures were very similar for the english and spanish surveys. however, item response theory-based methods for investigating differential item functioning (dif) revealed that several items demonstrat ...017288068
effect of bizhongxiao decotion (bzxd) on some cytokines in plasma of rats with cii-induced rheumatoid arthritis.to investigate the influence of bizhongxiao decoction (bzxd) which is a traditional chinese medicine for ra including, on the plasma tnf-α and il-1β in rats with cii-induced arthritis (cia) and explore the protective mechanism of bzxd in the treatment of rheumatoid arthritis.023674954
saddle embolism of the aorta with sudden paraplegia. 015646454
an empirical evaluation of alternative methods of estimation for confirmatory factor analysis with ordinal data.confirmatory factor analysis (cfa) is widely used for examining hypothesized relations among ordinal variables (e.g., likert-type items). a theoretically appropriate method fits the cfa model to polychoric correlations using either weighted least squares (wls) or robust wls. importantly, this approach assumes that a continuous, normal latent process determines each observed variable. the extent to which violations of this assumption undermine cfa estimation is not well-known. in this article, th ...015598100
the prevalence of glaucoma in bangladesh: a population based survey in dhaka division.few studies have reported on the epidemiology and clinical characteristics of glaucoma in south asia. this project aimed to determine the prevalence of glaucoma of dhaka, bangladesh.015548796
t-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis.two distinct clinical phenotypes of experimental autoimmune encephalomyelitis are observed in balb interferon-gamma knockout mice immunized with encephalitogenic peptides of myelin basic protein. conventional disease, characterized by ascending weakness and paralysis, occurs with greater frequency after immunizing with a peptide comprising residues 59 to 76. axial-rotatory disease, characterized by uncontrolled axial rotation, occurs with greater frequency in mice immunized with a peptide corres ...015509523
development and validation of the subjective awareness of neuropsychological deficits questionnaire for children (sand-c).although lowered awareness of abilities has been associated with poorer outcome in adults with neurological compromise, a dearth of research exists examining whether lowered awareness exists in younger populations. using findings from recent literature and expert opinion, a 47-item subjective awareness of neuropsychological deficits questionnaire for children (sand-c) was created to assess awareness of cognitive functioning in 6 domains (attention, psychomotor, visual-spatial, language, memory, ...015969352
an affinity/avidity model of peripheral t cell regulation.we show in these studies that qa-1-dependent cd8+ t cells are involved in the establishment and maintenance of peripheral self tolerance as well as facilitating affinity maturation of cd4+ t cells responding to foreign antigen. we provide experimental evidence that the strategy used by the qa-1-dependent cd8+ t cells to accomplish both these tasks in vivo is to selectively downregulate t cell clones that respond to both self and foreign antigens with intermediate, not high or low, affinity/avidi ...015668735
neuropsychological predictors of academic underachievement in pediatric epilepsy: moderating roles of demographic, seizure, and psychosocial variables.academic underachievement is common in pediatric epilepsy. attempts to identify seizure and psychosocial risk factors for underachievement have yielded inconsistent findings, raising the possibility that seizure and psychosocial variables play a complex role in combination with other variables such as neuropsychological functioning. this study cross-validated a neuropsychological measurement model for childhood epilepsy, examined the relation between neuropsychological functioning and academic a ...015461681
lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes.the sophisticated microarchitecture of the lymph node, which is largely supported by a reticular network of fibroblastic reticular cells (frcs) and extracellular matrix, is essential for immune function. how frcs form the elaborate network and remodel it in response to lymphocyte activation is not understood. in this work, we established ertr7(+)gp38(+)vcam-1(+) frc lines and examined the production of the er-tr7 antigen. multiple chemokines produced by frcs induced t cell and dendritic cell che ...015381731
assessing stress in cancer patients: a second-order factor analysis model for the perceived stress scale.using the perceived stress scale (pss), perceptions of global stress were assessed in 111 women following breast cancer surgery and at 12 and 24 months later this is the first study to factor analyze the pss. the pss data were factor analyzed each time using exploratory factor analysis with oblique direct quartimin rotation. goodness-of-fit indices (root mean square error of approximation [rmsea]), magnitude and pattern of factor loadings, and confidence interval data revealed a two-factor solut ...015358877
psychometric properties of the posttraumatic cognitions inventory (ptci): a replication with motor vehicle accident survivors.this study examined the factor structure, internal consistency, concurrent validity, discriminant validity, and discriminative validity of the posttraumatic cognitions inventory (ptci; e. b. foa, a. ehlers, d. m. clark, d. f. tolin, and s. m. orsillo, 1999) in a sample of 112 individuals who had experienced a serious motor vehicle accident. results generally supported the 3-factor structure of the ptci: (a) negative cognitions about self, (b) negative cognitions about the world, and (c) self-bla ...015456384
the epidemiology of interstitial lung disease and its association with lung cancer.the criteria and terminology for diagnosing interstitial lung disease (ild), a diverse range of pulmonary fibrotic disorders that affect the alveoli of the lungs, have been variable and confusing; however, there have been recent major improvements to an internationally agreed classification. evidence from recent analyses of populations suggests that the incidence and prevalence rates of ild are on the increase, particularly when the broad definition of ild is used. in most patients with ild a ca ...015340372
scale development for perceived school climate for girls' physical activity.to test an original scale assessing perceived school climate for girls' physical activity in middle school girls.015899688
development and psychometric validation of a brief instrument to measure satisfaction with online training.nowadays, health care institutions are increasingly challenged with the need for perennial workforce training and documentation for regulatory compliance. hence, more and more institutions are looking at online training solutions to train their workforce. we developed and validated a brief instrument designed to measure user satisfaction with online training. we present the results of psychometric analysis of our instrument that was validated in an online hipaa training course by over 13,000 emp ...016779174
comparing the experiential and psychosocial dimensions of chronic pain in african americans and caucasians: findings from a national community sample.to ascertain whether non-hispanic african american and caucasian chronic pain sufferers differ or converge in their self-reports of pain experience and pain adjustment.015669950
psychometric analysis of the diagnostic evaluation of language variation assessment. 025883537
[the empirical distinctiveness of work engagement and workaholism among hospital nurses in japan : the effect on sleep quality and job performance].the aim of the present study is to demonstrate the distinctiveness of work engagement and workaholism by examining their relationships with sleep quality and job performance.026752805
a multigroup confirmatory factor analysis of the patient health questionnaire-9 among english- and spanish-speaking latinas.depression is a significant problem for ethnic minorities that remains understudied partly due to a lack of strong measures with established psychometric properties. one screening tool, the patient health questionnaire-9 (phq-9), which was developed for use in primary care has also gained popularity in research settings. the reliability and validity of the phq-9 has been well established among predominantly caucasian samples, in addition to many minority groups. however, there is little evidence ...021787063
understanding the psychological processes of the racial match effect in asian americans.some studies on mental health outcomes research have found that when clients and therapists are ethnically or racially matched, this tends to be related to greater satisfaction and better outcomes. however, the precise underlying mechanism for the match effect has not been extensively examined. in this experimental study, we tested the effect of racial match on critical counseling processes (i.e., therapist credibility and the working alliance) using a sample of 171 asian american respondents. w ...021574698
training attentional control in older adults.recent research has demonstrated benefits for older adults from training attentional control using a variable priority strategy, but the construct validity of the training task and the degree to which benefits of training transfer to other contexts are unclear. the goal of this study was to characterize baseline performance on the training task in a sample of 105 healthy older adults and to test for transfer of training in a subset (n = 21). training gains after 5 days and extent of transfer was ...021728889
examining the dimensionality of effortful control in preschool children and its relation to academic and socioemotional indicators.effortful control (ec) is an important developmental construct, associated with socioemotional growth, academic performance, and psychopathology. ec is defined as the ability to execute goal-directed behavior to inhibit or delay a prepotent response in favor of a subdominant response. extant research indicates that ec may be multidimensional. confirmatory factor analysis with a sample of 234 preschoolers was used to determine if tasks designed to measure ec were best described by hot (affectivel ...021553957
cognitive activities during adulthood are more important than education in building reserve.cognitive reserve is thought to reflect life experiences. which experiences contribute to reserve and their relative importance is not understood. subjects were 652 autopsied cases from the rush memory and aging project and the religious orders study. reserve was defined as the residual variance of the regressions of cognitive factors on brain pathology and was captured in a latent variable that was regressed on potential determinants of reserve. neuropathology variables included alzheimer's dis ...023131600
neuropathological associates of multiple cognitive functions in two community-based cohorts of older adults.studies of neuropathology-cognition associations are not common and have been limited by small sample sizes, long intervals between autopsy and cognitive testing, and lack of breadth of neuropathology and cognition variables. this study examined domain-specific effects of common neuropathologies on cognition using data (n = 652) from two large cohort studies of older adults. we first identified dimensions of a battery of 17 neuropsychological tests, and regional measures of alzheimer's disease ( ...021092373
systematic review of herbals as potential anti-inflammatory agents: recent advances, current clinical status and future perspectives.many synthetic drugs reported to be used for the treatment of inflammatory disorders are of least interest now a days due to their potential side effects and serious adverse effects and as they are found to be highly unsafe for human assistance. since the last few decades, herbal drugs have regained their popularity in treatment against several human ailments. herbals containing anti-inflammatory activity (aia) are topics of immense interest due to the absence of several problems in them, which ...022279370
factor structure validation of the alcohol dependence scale in a heavy drinking college sample.the prevalence of alcohol use disorders in college students necessitates that adequate measures exist to assess students for abuse and dependence. the alcohol dependence scale (ads) is a continuous measure of the severity of alcohol involvement found to have a unidimensional factor structure in clinical samples. the latent factor structure of the ads in college drinkers has not been examined and this study sought to replicate unidimensionality. heavy college drinkers (n=343) completed the ads. p ...022058604
family-faculty trust as measured with the essp.the degree to which parents and teachers perceive they are working together in the best educational interests of children is a critical aspect of school culture. in previous work by hoy, tarter, and woolfolk hoy (2006), the phenomenon was named faculty trust and was measured with data from teachers. the current study builds upon hoy et al.'s work by recommending that measures of faculty trust capture the important reciprocal nature of trust and cooperation between schools and families that is th ...021935345
observed parenting behavior with teens: measurement invariance and predictive validity across race.previous reports supporting measurement equality between european american and african american families have often focused on self-reported risk factors or observed parent behavior with young children. this study examines equality of measurement of observer ratings of parenting behavior with adolescents during structured tasks; mean levels of observed parenting; and predictive validity of teen self-reports of antisocial behaviors and beliefs using a sample of 163 african american and 168 europe ...021787057
holistic reasoning on the other side of the world: validation of the analysis-holism scale in mexicans.the universality of cognitive processes has been called into question. research suggests that individuals from eastern cultures (e.g., china, korea) when compared to individuals from western cultures (e.g., the united states) prefer to reason holistically. this line of research has not been extended to cultural groups far removed from cultures traditionally surveyed in cross-cultural research such as hispanics. we conducted two studies to understand: 1) the generalizability of the construct of h ...021787065
psychometric validation of a short acculturation scale for korean immigrants.acculturation has been identified as a determinant of health behavior and outcome among ethnic minorities. the high prevalence of lifestyle-related chronic diseases and risk factors among korean immigrants calls for a valid short acculturation scale to use in clinical practice and health research settings.021677595
comparison of the concurrent and predictive validity of three measures of readiness to change marijuana use in a clinical sample of adolescents.the measurement of readiness to change has become common practice in alcohol and drug treatment of both adults and adolescents. nevertheless, there is relatively little research on the validity of measures of readiness to change among treated adolescents. the purpose of this study was to compare three measures of readiness to change marijuana use commonly used in clinical research and practice with adolescents: the readiness ruler, the stages of change readiness and treatment eagerness scale (so ...021683041
child-report data and assessment of the social environment in schools.objectives: this study tested the quality of data collected with the online essp for children from a diverse sample of 1,172 third through fifth graders. methods: mplus confirmatory factor analysis (cfa) procedures for ordinal and clustered data were used. results: of 80 original items, 61 loaded on 13 dimensions in a first-order model that had good fit in three random subsamples. children in grades 3 through 5 may not be reliable reporters about neighborhood adults' caring. however, 12 statisti ...021709776
basic information processing abilities at 11 years account for deficits in iq associated with preterm birth.although it is well established that preterms as a group do poorly relative to their full-term peers on tests of global cognitive functioning, the basis for this relative deficiency is less understood. the present paper examines preterm deficits in core cognitive abilities and determines their role in mediating preterm/full-term differences in iq. the performance of 11-year-old children born preterm (birth weight <1750g) and their full-term controls were compared on a large battery of 15 tasks, ...021643482
drinking style and dating violence in a sample of urban, alcohol-using youth.this study examined childhood abuse, problem behavior, drinking style, and dating violence (dv). our goal was to assess whether (a) alcohol use-related beliefs and behaviors ("drinking style") would be associated with dv perpetration and victimization, (b) drinking style would mediate the relationship between childhood abuse and dv, and (c) the drinking style-dv relationship would be attributable to propensity for problem behavior.021683037
exploring parent-adolescent communication about gender: results from adolescent and emerging adult samples.although parents are assumed to be children's primary models of socialization when it comes to gender, little is known about direct communication of gendered values in the family. accordingly, this study assessed the amount and content of recalled parental gender socialization messages using data from 291 u.s. college undergraduates attending a large midwestern university and 259 u.s. adolescents enrolled in public high schools in the midwest. the study examined the amount and content of parenta ...021712963
visual context processing deficits in schizophrenia: effects of deafness and disorganization.visual illusions allow for strong tests of perceptual functioning. perceptual impairments can produce superior task performance on certain tasks (i.e., more veridical perception), thereby avoiding generalized deficit confounds while tapping mechanisms that are largely outside of conscious control. using a task based on the ebbinghaus illusion, a perceptual phenomenon where the perceived size of a central target object is affected by the size of surrounding inducers, we tested hypotheses related ...021700590
differential item functioning of pathological gambling criteria: an examination of gender, race/ethnicity, and age.this study tested for the presence of differential item functioning (dif) in dsm-iv pathological gambling disorder (pgd) criteria based on gender, race/ethnicity and age. using a nationally representative sample of adults from the national epidemiologic survey on alcohol and related conditions (nesarc), indicating current gambling (n = 10,899), multiple indicator-multiple cause (mimic) models tested for dif, controlling for income, education, and marital status. compared to the reference groups ...020623329
factorial invariance, scale reliability, and construct validity of the job control and job demands scales for immigrant workers: the multi-ethnic study of atherosclerosis.immigrants have a different social context from those who stay in their home country or those who were born to the country that immigrants now live. cultural theory of risk perception suggests that social context influences one's interpretation of questionnaire items. we examined psychometric properties of job control and job demand scales with us- and foreign-born workers who preferred english, spanish, or chinese (n = 3,114, mean age = 58.1). across all groups, the job control scale had accept ...020582720
germinal center b cell and t follicular helper cell development initiates in the interfollicular zone.we identify the interfollicular (if) zone as the site where germinal center b cell and t follicular helper (tfh) cell differentiation initiates. for the first 2 days postimmunization, antigen-specific t and b cells remained confined within the if zone, formed long-lived interactions, and upregulated the transcriptional repressor bcl6. t cells also acquired the tfh cell markers cxcr5, pd-1, and gl7. responding b and t cells migrated to the follicle interior directly from the if zone, t cell immig ...021636295
measuring quality of life with sf-36 in older americans with traumatic brain injury. 025411585
validity of the process of change for colorectal cancer screening among african americans.process of change (poc) is a construct of the transtheoretical model that proposes to promote healthy behaviors.021165726
a confirmatory factor analysis of the structure of statistics anxiety measure: an examination of four alternative models.the aim of this study is to explore the confirmatory factor analysis results of the persian adaptation of statistics anxiety measure (sam), proposed by earp.022952530
childhood adhd symptoms and risk for cigarette smoking during adolescence: school adjustment as a potential mediator.although a large body of research suggests that children with attention-deficit/hyperactivity disorder (adhd) are at increased risk for cigarette smoking during adolescence compared with their non-adhd peers, much less research has examined why. the current study addressed this gap in the literature by examining middle school adjustment, broadly defined, as a possible mediator of the relation between childhood adhd symptoms and cigarette smoking during middle adolescence (10th grade). longitudin ...021401217
pancreatic enzyme therapy for pancreatic exocrine insufficiency. 021869872
victim-offender relationship status moderates the relationships of peritraumatic emotional responses, active resistance, and posttraumatic stress symptomatology in female rape survivors.this study examined whether the level of victim-offender relationship (vor) moderated the relationship between peritraumatic fear and active resistance as well as the relationship between peritraumatic fear and posttraumatic stress symptom severity in a community sample of female rape survivors. one hundred thirty-five participants were interviewed about their emotional and behavioral responses during the rape and assessed for posttraumatic stress symptomatology within one month of the assault. ...021731797
a confirmatory factor analysis of home environment and home social behavior data from the elementary school success profile for families.the purpose of the current study was to test the factor structure and scale quality of data provided by caregivers about the home environment and child behavior at home using the elementary school success profile (essp) for families. the essp for families is one component of the essp, an online social-environmental assessment that also collects information from students and teachers. confirmatory factor analyses with mplus and weighted least squares means and variances adjusted estimation took i ...021709777
relational uncertainty and cortisol responses to hurtful and supportive messages from a dating partner.this paper evaluates theoretical claims linking relational uncertainty about a relationship partner to experiences of stress during interactions with that partner. two observational studies were conducted to evaluate the association between relational uncertainty and salivary cortisol in the context of hurtful and supportive interactions. in study 1, participants (n = 89) engaged in a conversation about core traits or values with a partner, who was trained to be hurtful. in study 2, participants ...021686068
assessment of dietary restraint: psychometric properties of the revised restraint scale in hong kong adolescents.the psychometric properties of the revised restraint scale (rrs) have been well established in western populations but not in chinese adolescents.021553306
defining "occludable" angles in population surveys: drainage angle width, peripheral anterior synechiae, and glaucomatous optic neuropathy in east asian people./aim: a current consensus in epidemiological studies of primary angle closure (pac) is to diagnose the condition only if the posterior (usually pigmented) trabecular meshwork is seen for less than 90 degrees of the angle circumference, termed an "occludable angle." the authors sought to assess the validity of this epidemiological classification by exploring the relation between drainage angle width, peripheral anterior synechiae (pas) and glaucomatous optic neuropathy (gon).015031161
in vivo targeting of antigens to maturing dendritic cells via the dec-205 receptor improves t cell vaccination.the prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of antigen-specific t cell immunity. to assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the dec-205 receptor, an endocytic receptor that is abundant on these cells in lymphoid tissues. simultaneously, we injected agonistic alpha-cd40 antibody to mature the dendritic cells. we fo ...015024047
statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts.hmg-coa reductase inhibitors (statins) broadly reduce cardiovascular events, effects that are only partly related to cholesterol lowering. recent studies suggest important anti-inflammatory and antiproliferative properties of these drugs. the purpose of this study was to determine the influence of statin therapy on graft patency after autogenous infrainguinal arterial reconstructions.015192555
estrogen receptor-1 (esr1) and -2 (esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice.estrogens and estrogen-receptor signaling function in establishing and regulating the female immune system and it is becoming increasingly evident that they may play a similar role in males. we report that b10.pl/snj male mice with a disrupted estrogen receptor-1 (alpha) gene (esr1(-/-)) develop less severe clinical experimental allergic encephalomyelitis (eae) compared to either esr1(+/-) or wild-type (esr1(+/+)) controls when immunized with myelin basic protein peptide ac1-11 (mbp(ac1-11)). in ...015161628
mental health provider attitudes toward adoption of evidence-based practice: the evidence-based practice attitude scale (ebpas).mental health provider attitudes toward organizational change have not been well studied. dissemination and implementation of evidence-based practices (ebps) into real-world settings represent organizational change that may be limited or facilitated by provider attitudes toward adoption of new treatments, interventions, and practices. a brief measure of mental health provider attitudes toward adoption of ebps was developed and attitudes were examined in relation to a set of provider individual d ...015224451
therapeutic polypeptides based on hbcag(18-27) ctl epitope can induce antigen-specific cd(8)(+) ctl-mediated cytotoxicity in hla-a2 transgenic mice.to explore how to trigger an hlai-restricted cd8(+) t cell response to exogenously synthesized polypeptides in vivo.015069731
b cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice.one mechanism whereby b cells contribute to type 1 diabetes in nonobese diabetic (nod) mice is as a subset of apcs that preferentially presents mhc class ii-bound pancreatic beta cell ags to autoreactive cd4 t cells. this results from their ability to use cell surface ig to specifically capture beta cell ags. hence, we postulated a diabetogenic role for defects in the tolerance mechanisms normally blocking the maturation and/or activation of b cells expressing autoreactive ig receptors. we compa ...015067092
women's situational coping with acquaintance sexual assault: applying an appraisal-based model.drawing on theories of appraisal-based coping, the present study applied structural modeling to examine relationships among personal goal orientations, primary and secondary appraisals of acquaintance sexual assault, and women's emotional and behavioral responses to it. based on 415 college women's reports of a sexual assault experience, the model shows both direct and indirect effects. assertive, diplomatic, and immobilized responding were each predicted by a unique profile of appraisals and or ...026345173
inflammatory cytokines overcome age-related defects in cd4 t cell responses in vivo.age-related decreases in immune function are thought to contribute to the reduced efficacy of vaccinations seen in elderly populations. our previous in vitro studies demonstrated that naive cd4 t cells from aged tcr-transgenic mice proliferate less than young cells and generate poorly functioning effectors due to decreased il-2 production. in this current study, we show that this age-related defect in cd4 t cell response also occurs in vivo and that it is correlated with reduced nf-kappa b activ ...015100256
transcatheter embolization in pelvic trauma.this article outlines the clinical and radiological approach to patients with pelvic trauma. it reviews the clinical descriptions and classifications of pelvic trauma as well as the management of patients with stable and unstable fractures. a review of embolization techniques in these types of patients is provided.021331106
tnf autovaccination induces self anti-tnf antibodies and inhibits metastasis in a murine melanoma model.tnf is a proinflammatory cytokine involved in the pathogenesis of chronic inflammatory diseases, but also in metastasis in certain types of cancer. in terms of therapy, tnf is targeted by anti-tnf neutralising monoclonal antibodies or soluble tnf receptors. recently, a novel strategy based on the generation of self anti-tnf antibodies (tnf autovaccination) has been developed. we have previously shown that tnf autovaccination successfully generates high anti-tnf antibody titres, blocks tnf and am ...015026813
generation of b220low b cells and production of autoantibodies in mice with experimental amyloidosis: association of primordial t cells with this phenomenon.to investigate the immunological state in amyloidosis, mice were twice intraperitoneally injected (2-week interval) with casein emulsified in complete freund's adjuvant. two weeks after the treatment, amyloid deposits were detected in the spleen and other organs of these mice. the number of lymphocytes yielded by the liver and spleen increased significantly. the most affected lymphocyte subset was found to be b cells, namely, the total number of b cells increased and unusual b220low b cells were ...014738446
gammadelta t-cell clones from intestinal intraepithelial lymphocytes inhibit development of ctl responses ex vivo.oral administration of antigen induces a state of tolerance that is associated with activation of cd8+ t cells that can transfer unresponsiveness to naïve syngeneic hosts. these t cells are not lytic, but they inhibit development of antibody, cd4+ t helper cell, and cd8+ cytotoxic t lymphocyte (ctl) responses upon adoptive transfer into naïve, syngeneic mice. in addition, we have shown that depletion of gammadelta t cells by injection of the anti-delta chain antibody (gl3) down modulates the exp ...015027900
the impact of visit frequency on the relationship between service quality and outpatient satisfaction: a south korean study.to examine the relative impact of four service quality dimensions on outpatient satisfaction and to test the invariance of the structural relationships between the service quality dimensions and satisfaction across three patient groups of varying numbers of prior visits to the same hospital as outpatients.014965075
direct expansion of functional cd25+ cd4+ regulatory t cells by antigen-processing dendritic cells.an important pathway for immune tolerance is provided by thymic-derived cd25+ cd4+ t cells that suppress other cd25- autoimmune disease-inducing t cells. the antigen-presenting cell (apc) requirements for the control of cd25+ cd4+ suppressor t cells remain to be identified, hampering their study in experimental and clinical situations. cd25+ cd4+ t cells are classically anergic, unable to proliferate in response to mitogenic antibodies to the t cell receptor complex. we now find that cd25+ cd4+ ...012874257
high-risk pools for uninsurable individuals: recent growth, future prospects.high-risk pools are state programs that were recently brought under federal review by the health insurance portability and accountability act of 1996 (hipaa). for a subsidized, yet above-standard premium, they provide coverage to individuals lacking access to private health insurance, typically due to pre-existing conditions. reducing high-risk pool premiums in all states to the level prevailing in the most generous states (at an annual cost of about $105 million) could lead to a modest but sign ...025372064
further validation of the multidimensional fatigue symptom inventory-short form.a growing body of evidence is documenting the multidimensional nature of cancer-related fatigue. although several multidimensional measures of fatigue have been developed, further validation of these scales is needed. to this end, the current study sought to evaluate the factorial and construct validity of the 30-item multidimensional fatigue symptom inventory-short form (mfsi-sf). a heterogeneous sample of 304 cancer patients (mean age 55 years) completed the mfsi-sf, along with several other m ...014711465
impact of camp on the t-cell response to type ii collagen.there is considerable interest in the possible use of camp-elevating agents in the treatment of autoimmune diseases such as rheumatoid arthritis. the objective of this study was to evaluate the impact of different camp-elevating agents on the t-cell response to type ii collagen within the context of collagen-induced arthritis, a murine model of rheumatoid arthritis. spleen cells or lymph node cells from type-ii-collagen-immunized dba/1 mice were cultured in the presence of type ii collagen plus ...014678197
systemic antibodies towards mucosal bacteria in ulcerative colitis and crohn's disease differentially activate the innate immune response.the mucosa in ulcerative colitis (uc) is replete with antibody producing plasma b cells and polymorphonuclear leucocytes (pmn). this combination of effector cells requires a crosslinking antigen to evoke an antibody driven pmn inflammatory response via their fc receptors. the stimulus for activation is thought to be commensal bacteria colonising the gut mucosa. the aim of this investigation was to compare the principal culturable bacterial populations on the rectal mucosa of uc patients, and to ...014684582
psychometric utility of the childhood trauma questionnaire with female street-based sex workers.the present study examines the psychometric properties of a verbal, face-to-face administration of the childhood trauma questionnaire (ctq) with female street-based sex workers (n = 171). confirmatory factor analysis (cfa) indicated a poor fit between our data and the instrument's established 5-factor structure. exploratory factor analysis (efa) yielded four stable and usable factors corresponding to the emotional abuse, emotional neglect, physical abuse, and sexual abuse subscales of the ctq; t ...016957783
mast cells are required for experimental oral allergen-induced diarrhea.gastrointestinal allergic disorders represent a diverse spectrum of inflammatory diseases that are occurring with increasing incidence and severity. an essential question concerning these disorders is to determine the specific cells and mediators responsible for specific clinical manifestations. with this in mind, we developed a murine model of oral allergen-induced intestinal inflammation accompanied by strong th2-associated humoral and cellular responses and focused on the immunopathogenesis o ...014660743
promising survival for patients with glioblastoma multiforme treated with individualised chemotherapy based on in vitro drug sensitivity testing.we retrospectively investigated the efficacy and feasibility of individualised chemotherapy based on in vitro drug sensitivity testing (dst) for patients with glioblastoma multiforme. a total of 40 consecutive patients with glioblastoma multiforme (gm) were enrolled into this study between january 1995 and december 2000. the flow cytometric (fcm) detection of apoptosis was used to determine the in vitro sensitivity of tumour cells obtained at surgery to 30 different kinds of anticancer agents. f ...014612899
the use of latent trajectory models in psychopathology research.despite the recent surge in the development of powerful modeling strategies to test questions about individual differences in stability and change over time, these methods are not currently widely used in psychopathology research. in an attempt to further the dissemination of these new methods, the authors present a pedagogical introduction to the structural equation modeling based latent trajectory model, or ltm. they review several different types of ltms, discuss matching an optimal ltm to a ...014674867
hepatitis c antibodies among blood donors, senegal, 2001. 014725259
pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis.idiopathic pulmonary fibrosis (ipf) is a progressive, usually fatal, form of interstitial lung disease characterized by failure of alveolar re-epithelialization, persistence of fibroblasts/myofibroblasts, deposition of extracellular matrix, and distortion of lung architecture which ultimately results in respiratory failure. clinical ipf is associated with a histopathological pattern of usual interstitial pneumonia (uip) on surgical lung biopsy. therapy for this disease with glucocorticoids and o ...014595745
cd25+, interleukin-10-producing cd4+ t cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye.an important factor in the establishment of ocular immune privilege is the dynamic down regulation of t helper 1 (th1) immune responses that occurs in response to antigens delivered intraocularly; a phenomenon that has been termed anterior chamber-associated immune deviation (acaid). acaid is characterized by the generation of splenic regulatory cells that inhibit the expression of delayed-type hypersensitivity. previous studies have shown that antigens introduced into the anterior chamber of th ...012941137
prevalence of glaucoma in thailand: a population based survey in rom klao district, bangkok.to determine prevalence, demography, mechanism, and visual morbidity of glaucoma in urban thai people.012928267
gamma delta t cells provide an early source of interferon gamma in tumor immunity.interferon (ifn)-gamma is necessary for tumor immunity, however, its initial cellular source is unknown. because gammadelta t cells primarily produce this cytokine upon activation, we hypothesized that they would provide an important early source of ifn-gamma in tumor immunosurveillance. to address this hypothesis, we first demonstrated that gammadelta t cell-deficient mice had a significantly higher incidence of tumor development after challenge with a chemical carcinogen methylcholanthrene (mc ...012900519
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