Publications

parent-reported attention deficit/hyperactivity symptomatology in preschool-aged children: factor structure, developmental change, and early risk factors.	although attention deficit/hyperactivity disorder (adhd) has increasingly been studied in preschool-aged children, relatively few studies have provided a comprehensive evaluation of the factor structure and patterns of developmental changes in parent-reported adhd symptomatology across the early childhood period. this study used confirmatory factor analyses to test for longitudinal measurement invariance of adhd symptoms and semi-parametric finite mixture models to identify prototypic patterns o ...	22581375
human umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model.	to investigate the effect of human umbilical cord stem cells, both mesenchymal and hematopoietic (cd34+), in the treatment of arthritis.	23189211
examining the association between implementation and outcomes : state-wide scale-up of school-wide positive behavior intervention and supports.	although there is an established literature supporting the efficacy of a variety of prevention programs, there has been less empirical work on the translation of such research to everyday practice or when scaled-up state-wide. there is a considerable need for more research on factors that enhance implementation of programs and optimize outcomes, particularly in school settings. the current paper examines how the implementation fidelity of an increasingly popular and widely disseminated preventio ...	22836758
preprotachykinin-a gene disruption attenuates nociceptive sensitivity after opioid administration and incision by peripheral and spinal mechanisms in mice.	the preprotachykinin a gene (ppt-a) codes for substance p (sp), supports nociceptive sensitization, and modulates inflammatory responses after incision. repeated opioid use produces paradoxical pain sensitization-termed opioid-induced hyperalgesia (oih) -which can exacerbate pain after incision. here the contribution of sp to peri-incisional nociceptive sensitization and nociceptive mediator production after opioid treatment was examined utilizing ppt-a knockout (-/-) mice and the neurokinin (nk ...	23031399
helminth infections and host immune regulation.	helminth parasites infect almost one-third of the world's population, primarily in tropical regions. however, regions where helminth parasites are endemic record much lower prevalences of allergies and autoimmune diseases, suggesting that parasites may protect against immunopathological syndromes. most helminth diseases are spectral in nature, with a large proportion of relatively asymptomatic cases and a subset of patients who develop severe pathologies. the maintenance of the asymptomatic stat ...	23034321
monoclonal and polyclonal antibodies specific for foot and mouth disease virus type a and type o vp1.	the foot and mouth disease virus (fmdv) is an rna virus composed of single stranded positive sense rna. fmdv has been known to infect cloven-hoofed animals, including pigs, cattle, and sheep. fmdv is rapidly spreading outward to neighboring regions, often leading to a high mortality rate. thus, early diagnosis of fmdv is critical to suppress propagation of fmdv and minimize economic losses. in this study, we report the generation and characterization of polyclonal and six monoclonal antibodies a ...	23098303
unravelling the mystery of capsaicin: a tool to understand and treat pain.	a large number of pharmacological studies have used capsaicin as a tool to activate many physiological systems, with an emphasis on pain research but also including functions such as the cardiovascular system, the respiratory system, and the urinary tract. understanding the actions of capsaicin led to the discovery its receptor, transient receptor potential (trp) vanilloid subfamily member 1 (trpv1), part of the superfamily of trp receptors, sensing external events. this receptor is found on key ...	23023032
a comparison of latent class, latent trait, and factor mixture models of dsm-iv borderline personality disorder criteria in a community setting: implications for dsm-5.	with the fifth edition of the diagnostic and statistical manual of mental disorders (dsm-5) scheduled for publication in 2013, researchers continue to debate the optimal classification of borderline personality disorder (bpd). much of the discussion has focused on the relative merits of dimensional versus categorical classification schemes for bpd. advances in statistical technologies have made it possible to adjudicate between continuous and categorical models of bpd using quantitative methods, ...	23013346
review of animal models of neuromyelitis optica.	neuromyelitis optica (nmo) is a recurrent neuroinflammatory disease of the optic nerves and spinal cord associated with the anti-aquaporin-4 (aqp4) antibody biomarker, nmo-igg. as clinical and scientific research interest in nmo grows, the need for an animal model becomes more urgent. over the past few years, several groups have developed rodent models that partially represent human nmo disease. passive transfer of the nmo-igg is not pathogenic alone, but in certain contexts can recruit granuloc ...	24555175
evaluation of anti-arthritic potential of the methanolic extract of the aerial parts of costus speciosus.	costus speciosus koen. (keu, crape ginger), an ornamental plant, widely distributed in india is traditionally used as astringent, aphrodisiac, purgative, anthelmintic, depurative, febrifuge and expectorant. the plant is also used in rheumatism, dropsy, urinary diseases and jaundice. the purpose of this study is to evaluate the anti-arthritic activity of the methanolic extract of the aerial parts of costus speciosus (cs) in experimental animal models.	23326092
callous-unemotional traits as unique prospective risk factors for substance use in early adolescent boys and girls.	youth with elevated conduct disorder (cd) symptoms who also have callous-unemotional (cu) traits exhibit more antisocial behavior than youth without cu traits. however, evidence regarding whether cu traits increase risk of substance use over and above cd symptoms, and whether these associations differ for boys and girls, is scarce. using the developmental pathways project sample of 521 middle school students, we examined whether adolescent- and parent-reported cu traits measured in 6th grade pro ...	22453863
clinical implications of enteroadherent escherichia coli.	pathogenic escherichia coli that colonize the small intestine primarily cause gastrointestinal illness in infants and travelers. the main categories of pathogenic e. coli that colonize the epithelial lining of the small intestine are enterotoxigenic e. coli, enteropathogenic e. coli, and enteroaggregative e. coli. these organisms accomplish their pathogenic process by a complex, coordinated multistage strategy, including nonintimate adherence mediated by various adhesins. these so called "entero ...	22798032
bacillus-derived poly-γ-glutamic acid reciprocally regulates the differentiation of t helper 17 and regulatory t cells and attenuates experimental autoimmune encephalomyelitis.	forkhead box protein 3 (foxp3(+)) regulatory t (t(reg)) cells and interleukin (il)-17-producing t helper 17 (th17) cells have opposing effects on autoimmunity, as the former are crucial for maintaining self-tolerance while the latter play a key role in precipitating inflammatory autoimmune diseases. here we report that bacillus-derived poly-γ-glutamic acid (γ-pga) signals naive cd4(+) t cells to promote the selective differentiation of t(reg) cells and to suppress the differentiation of th17 cel ...	22943202
substance use progression from adolescence to early adulthood: effortful control in the context of friendship influence and early-onset use.	in a sample of 998 ethnically diverse adolescents, a multiagent, multimethod approach to the measurement of adolescent effortful control, adolescent substance use, and friendship influence was used to predict escalations to early-adult tobacco, alcohol, and marijuana use by ages 22-23. structural equation modeling revealed that adolescent substance use and friends' substance use tended to be highly correlated and together were robust predictors of a problematic pattern of usage for all substance ...	22527607
item response theory and validity of the neo-ffi in adolescents.	the present study applied item response theory (irt) to the neo five factor inventory (neo-ffi) completed by a community based sample of adolescents. the results revealed that many of these personality items may not be discriminating well, with some traits demonstrating greater reliability than others. furthermore, the threshold values highlighted that the majority of the items had skewed responses, suggesting a limited utility of some response categories. generally, removing poorly discriminati ...	23049153
subjective cognitive complaints of older adults at the population level: an item response theory analysis.	subjective cognitive complaints (sccs) are increasingly a focus in studies on prodromal alzheimer disease (ad) and risk for dementia. little is known about the optimal approach to measure sccs. we used item response theory (irt) to examine the characteristics of 24 scc items in a sample of 3495 older adults pooled from 4 community-based studies. we investigated the potential advantages of irt scoring over conventional scoring on the basis of participants' item response patterns. items most likel ...	22193355
observed personality in childhood: psychometric and behavioral genetic evidence of two broad personality factors.	we examined broad dimensions of children's personalities (total n = 1056; age = 3.5 to 12 years) based on observers' perceptions following a few hours of structured interaction. siblings' behaviors during a two-hour cognitive assessment in the home were rated separately by two different observers. exploratory and confirmatory factor analyses clearly revealed a two-factor solution in three different samples. there was correspondence between parent-rated temperament and the observer-rated factors. ...	24932065
il-17-deficient allogeneic bone marrow transplantation prevents the induction of collagen-induced arthritis in dba/1j mice.	il-17-producing cd4+ t cells (th17) play important functions in autoimmune diseases and allograft rejection of solid organs. we examined the effects of il 17 and its mechanism of action on arthritis in a murine collagen-induced arthritis (cia) model using bone marrow transplantation (bmt) system. dba/1j mice were administered a lethal radiation dose and then rescued with bone marrow derived from either wild-type (wt) or il-17-/- mice on c57bl/6 background mice. cia was induced after the bone mar ...	23114425
positive and negative thinking in tinnitus: factor structure of the tinnitus cognitions questionnaire.	researchers and clinicians consider thinking to be important in the development and maintenance of tinnitus distress, and altering thoughts or thinking style is an object of many forms of psychological therapy for tinnitus. those working with people with tinnitus require a reliable, psychometrically robust means of measuring both positive and negative thinking related to it. the tinnitus cognitions questionnaire (tcq) was designed as such a measure and its authors showed it to be reliable, with ...	27560491
quantifying and valuing community health worker time in improving access to malaria diagnosis and treatment.	community health workers (chws) are members of a community who are chosen by their communities as first-line, volunteer health workers. the time they spend providing healthcare and the value of this time are often not evaluated. our aim was to quantify the time chws spent on providing healthcare before and during the implementation of an integrated program of diagnosis and treatment of febrile illness in 3 african countries.	27941108
compliance with referral advice after treatment with prereferral rectal artesunate: a study in 3 sub-saharan african countries.	children aged <5 years were enrolled in a large study in 3 countries of sub-saharan africa because they had danger signs preventing them from being able to take oral medications. we examined compliance and factors associated with compliance with referral advice for those who were treated with rectal artesunate.	27941106
motivation of community health workers in diagnosing, treating, and referring sick young children in a multicountry study.	community health workers (chws) are an important element of care provision for a wide range of conditions, but their turnover rate is high. many studies have been conducted on health workers' motivation, focusing on formal sector staff but not chws. although chws are easy to recruit, motivating and retaining them for service delivery is difficult. this article investigates factors influencing chw motivation and retention in health service delivery.	27941104
impact of improving community-based access to malaria diagnosis and treatment on household costs.	community health workers (chws) were trained in burkina faso, nigeria, and uganda to diagnose febrile children using malaria rapid diagnostic tests, and treat positive malaria cases with artemisinin-based combination therapy (act) and those who could not take oral medicines with rectal artesunate. we quantified the impact of this intervention on private household costs for childhood febrile illness.	27941102
feasibility of malaria diagnosis and management in burkina faso, nigeria, and uganda: a community-based observational study.	malaria-endemic countries are encouraged to increase, expedite, and standardize care based on parasite diagnosis and treat confirmed malaria using oral artemisinin-based combination therapy (act) or rectal artesunate plus referral when patients are unable to take oral medication.	27941101
the role of p2x3 receptors in bilateral masseter muscle allodynia in rats.	to determine the relationship between bilateral allodynia induced by masseter inflammation and p2x3 receptor expression changes in trigeminal ganglia (trg) and the influence of intramasseteric p2x3 antagonist administration on bilateral masseter allodynia.	28051277
personality stability from age 14 to age 77 years.	there is evidence for differential stability in personality trait differences, even over decades. the authors used data from a sample of the scottish mental survey, 1947 to study personality stability from childhood to older age. the 6-day sample (n = 1,208) were rated on six personality characteristics by their teachers at around age 14. in 2012, the authors traced as many of these participants as possible and invited them to take part in a follow-up study. those who agreed (n = 174) completed ...	27929341
remap-a resilience resources measure for prediction and management of somatic symptoms.	patients with symptoms but without an identified disease are a challenge to primary care providers. a 22-item measure is introduced and evaluated to offer medical care providers with an instrument to assess and discuss possible deficiencies in resilience resources that may contribute to symptoms without identifiable pathology. this instrument highlights psychosocial and lifestyle resources that serve as buffers to life's stressors rather than focusing on stress and its related symptoms.	27067083
usefulness and safety of the "god's hand" pneumatic compression device for hemostasis in femoral catheterization.	we aimed to assess the usefulness and safety of the god's hand pneumatic compression device for hemostasis in patients undergoing percutaneous endovascular procedures via femoral artery.	27856404
programmed death-1 culls peripheral accumulation of high-affinity autoreactive cd4 t cells to protect against autoimmunity.	self-reactive cd4 t cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. here, we show an essential role for the coinhibitory molecule programmed death-1 (pd-1) in silencing the activation of high-affinity autoreactive cd4 t cells. each wave of self-reactive cd4 t cells that escapes thymic deletion autonomously upregulates pd-1 to maintain self-tolerance. by tracking the progeny derived from in ...	27829150
dw2007 ameliorates colitis and rheumatoid arthritis in mice by correcting th17/treg imbalance and inhibiting nf-κb activation.	in the previous study, the rhizome mixture of anemarrhena asphodeloides and coptis chinensis (dw2007), improved tnbs-, oxazolone-, or dss-induced colitis in mice by regulating macrophage activation. therefore, to understand the effect of dw2007 on the t cell differentiation involved in the adaptive immunity, we measured its effect on both th17 and treg cell differentiation in splenocytes, in the lamina propria of mice with dss-induced colitis (dic), and in the spleens of mice with collagen-induc ...	27302961
persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced mecp2 repression of glua1 in rat central amygdala.	as long-term opioids are increasingly used for control of chronic pain, how pain affects the rewarding effect of opioids and hence risk of prescription opioid misuse and abuse remains a healthcare concern and a challenging issue in current pain management. in this study, using a rat model of morphine self-administration, we investigated the molecular mechanisms underlying the impact of pain on operant behavior of morphine intake and morphine seeking before and after morphine withdrawal. we found ...	25716866
gender-specific responses to climate variability in a semi-arid ecosystem in northern benin.	highly erratic rainfall patterns in northern benin complicate the ability of rural farmers to engage in subsistence agriculture. this research explores gender-specific responses to climate variability in the context of agrarian benin through a household survey (n = 260) and an experimental gaming exercise among a subset of the survey respondents. although men and women from the sample population are equally aware of climate variability and share similar coping strategies, their specific land-use ...	27878534
preparation and characterization of a novel nanobody against t-cell immunoglobulin and mucin-3 (tim-3).	as t-cell immunoglobulin and mucin domain 3 (tim-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. based on the unique features of nanobodies, we aimed to construct an anti-tim-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes.	27917276
repair of the torn descending thoracic aorta using the centrifugal pump for partial left heart bypass.	to describe the relevant anatomy and sequential technical maneuvers to repair blunt injuries to the descending thoracic aorta with partial left heart bypass.	15213616
socioeconomic and gender group differences in early literacy skills: a multiple-group confirmatory factor analysis approach.	socioeconomic status and gender are important demographic variables that strongly relate to academic achievement. this study examined the early literacy skills differences between 4 sociodemographic groups, namely, boys ineligible for free or reduced-price lunch (frl), girls ineligible for frl, boys eligible for frl, and girls eligible for frl. data on kindergarteners (n = 462) were analysed using multiple-group confirmatory factory analysis. early literacy skill differences between boys and gir ...	25750582
tumor necrosis factor (tnf) receptor shedding controls thresholds of innate immune activation that balance opposing tnf functions in infectious and inflammatory diseases.	tumor necrosis factor (tnf) is a potent cytokine exerting critical functions in the activation and regulation of immune and inflammatory responses. due to its pleiotropic activities, the amplitude and duration of tnf function must be tightly regulated. one of the mechanisms that may have evolved to modulate tnf function is the proteolytic cleavage of its cell surface receptors. in humans, mutations affecting shedding of the p55tnf receptor (r) have been linked with the development of the tnfr-as ...	15289505
fibrotic disease and the t(h)1/t(h)2 paradigm.		15286725
dna vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific th2/3 cd4 t cell response in non-obese diabetic mice.	dna vaccination encoding beta cell autoantigens has been shown very recently to prevent type i diabetes in non-obese diabetic (nod) mice. however, dna vaccination encoding microbial or reporter antigens is known to induce specific long-lasting cd4 th1 and strong cytolytic cd8 t cell responses. as this immune phenotype is associated strongly with beta cell destruction leading to diabetes, we have chosen to study the effects of plasmids encoding glutamic acid decarboxylase (gad), a crucial beta ce ...	15270841
il-5 links adaptive and natural immunity specific for epitopes of oxidized ldl and protects from atherosclerosis.	during atherogenesis, ldl is oxidized, generating various oxidation-specific neoepitopes, such as malondialdehyde-modified (mda-modified) ldl (mda-ldl) or the phosphorylcholine (pc) headgroup of oxidized phospholipids (oxpls). these epitopes are recognized by both adaptive t cell-dependent (td) and innate t cell-independent type 2 (ti-2) immune responses. we previously showed that immunization of mice with mda-ldl induces a td response and atheroprotection. in addition, a pc-based immunization s ...	15286809
experience with the "good" limb induces aberrant synaptic plasticity in the perilesion cortex after stroke.	following unilateral stroke, the contralateral (paretic) body side is often severely impaired, and individuals naturally learn to rely more on the nonparetic body side, which involves learning new skills with it. such compensatory hyper-reliance on the "good" body side, however, can limit functional improvements of the paretic side. in rats, motor skill training with the nonparetic forelimb (npt) following a unilateral infarct lessens the efficacy of rehabilitative training, and reduces neuronal ...	26041926
trafficking of na+/ca2+ exchanger to the site of persistent inflammation in nociceptive afferents.	persistent inflammation results in an increase in the amplitude and duration of depolarization-evoked ca(2+) transients in putative nociceptive afferents. previous data indicated that these changes were the result of neither increased neuronal excitability nor an increase in the amplitude of depolarization. subsequent data also ruled out an increase in voltage-gated ca(2+) currents and recruitment of ca(2+)-induced ca(2+) release. parametric studies indicated that the inflammation-induced increa ...	26041911
assessing reactive and proactive aggression in detained adolescents outside of a research context.	the reactive proactive aggression questionnaire (rpq) is a self-report tool for assessing reactive aggression (ra) and proactive aggression (pa). this study contributes to the literature by testing the psychometric properties of the rpq across detained boys from various ethnicities whilst using data that were gathered during clinical assessments. the factorial, convergent, and criterion validity, and the internal consistency of the rpq scores received strong support in the total sample and acros ...	26031237
the 9th japan-korea joint meeting for vascular surgery.		26150901
measuring afterschool program quality using setting-level observational approaches.	as the importance of afterschool hours for youth development is widely acknowledged, afterschool settings have recently received increasing attention as an important venue for youth interventions. a range of intervention programs have been in place, generally aiming at positive youth development through enhancing the quality of programs. a growing need has thus arisen for reliable and valid measures of afterschool quality. this study examined the extent to which the two observational tools, i.e. ...	26819487
psychometric evaluation of the child ptsd symptom scale in spanish and english.	given the consistent growth of the latino population in the united states, there is a critical need for validated spanish measures to assess posttraumatic stress disorder (ptsd) symptoms in children. the current study examines the psychometric properties of the child ptsd symptom scale (cpss). we examined 259 children (8-17 years) who had experienced a recent traumatic event. study measures were completed in spanish (n = 106; boys = 58, girls = 48) or in english (n = 153; boys = 96, girls = 57). ...	25129027
rotation to a partially specified target matrix in exploratory factor analysis in practice.	the purpose of the present study was to explore the influence of the number of targets specified on the quality of exploratory factor analysis solutions with a complex underlying structure and incomplete substantive measurement theory. we extended previous research in this area by (a) exploring this phenomenon in situations in which both the common factor model and the targeted pattern matrix contained specification errors and (b) comparing the performance of target rotation to an easier-to-use ...	24903693
calcitonin gene-related peptide-expressing sensory neurons and spinal microglial reactivity contribute to pain states in collagen-induced arthritis.	to evaluate the contribution of sensory neurons in ankle joints and adjacent tissue to the development of pain in collagen-induced arthritis (cia), and to determine the relationship between pain and the appearance of clinical signs.	25707377
parkinson's disease subtypes in the oxford parkinson disease centre (opdc) discovery cohort.	within parkinson's there is a spectrum of clinical features at presentation which may represent sub-types of the disease. however there is no widely accepted consensus of how best to group patients.	26405788
effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice.	pain-related functional impairment and behavioral depression are diagnostic indicators of pain and targets for its treatment. nesting is an innate behavior in mice that may be sensitive to pain manipulations and responsive to analgesics. the goal of this study was to develop and validate a procedure for evaluation of pain-related depression of nesting in mice. male icr mice were individually housed and tested in their home cages. on test days, a 5- × 5-cm nestlet was subdivided into 6 pieces, th ...	25827812
measurement invariance of the short inventory of problems-revised across african american and non-latino white substance users.	this study investigated measurement invariance properties of the short inventory of problems - revised (sip-r) across racial groups. the sample included 195 african american and 194 non-latino white adult participants in a clinical trial investigating the effectiveness of motivational enhancement therapy in the national institute on drug abuse clinical trials network. the sip-r demonstrated configural invariance and weak metric invariance, suggesting conceptualizations of adverse consequences of ...	26207102
the nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of p2x2/3 receptors.	chronic pain is a highly prevalent and poorly managed human health problem. we used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (drg)-expressed genetic contributors to mechanical allodynia, a prominent symptom of chronic pain. we identified expression levels of chrna6, which encodes the α6 subunit of the nicotinic acetylcholine receptor (nachr), as highly associated with allodynia. we confirmed the importance of α6* (α6-containing) nachrs by a ...	25972004
depletion of t cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.	the enzyme lysostaphin possesses potent anti-staphylococcal activity and represents a promising antibacterial drug candidate; however, its immunogenicity poses a barrier to clinical translation. here, structure-based biomolecular design enabled widespread depletion of lysostaphin drb1(∗)0401 restricted t cell epitopes, and resulting deimmunized variants exhibited striking reductions in anti-drug antibody responses upon administration to humanized hla-transgenic mice. this reduced immunogenicity ...	26000749
galectin isolated from parasite inhibits remission of experimental autoimmune encephalomyelitis by up-regulating autoantibody.	recently, parasite infections or parasite-derived products have been suggested as a therapeutic strategy with suppression of immunopathology, which involves the induction of regulatory t cells or/and t helper type 2 (th2) responses. in a recent study, researchers reported that constructed recombinant galectin (rtl-gal) isolated from an adult worm of the gastrointestinal nematode parasite toxascaris leonina attenuated clinical symptoms of inflammatory bowel disease in mice treated with dextran su ...	25619397
an exploratory path model of the relationships between positive and negative adaptation to cancer on quality of life among non-hodgkin lymphoma survivors.	adaptation is an ongoing, cognitive process with continuous appraisal of the cancer experience by the survivor. this exploratory study tested a path model examining the personal (demographic, disease, and psychosocial) characteristics associated with quality of life (qol) and whether or not adaptation to living with cancer may mediate these effects. this study employed path analysis to estimate adaptation to cancer. a cross-sectional sample of nhl survivors (n = 750) was used to test the model. ...	25751114
development and initial evaluation of the sci-fi/at.	to describe the domain structure and calibration of the spinal cord injury functional index for samples using assistive technology (sci-fi/at) and report the initial psychometric properties of each domain.	26010975
measuring stigma after spinal cord injury: development and psychometric characteristics of the sci-qol stigma item bank and short form.	to develop a calibrated item bank and computer adaptive test (cat) to assess the effects of stigma on health-related quality of life in individuals with spinal cord injury (sci).	26010973
measuring self-esteem after spinal cord injury: development, validation and psychometric characteristics of the sci-qol self-esteem item bank and short form.	to describe the development and psychometric properties of the spinal cord injury-quality of life (sci-qol) self-esteem item bank.	26010972
measuring resilience after spinal cord injury: development, validation and psychometric characteristics of the sci-qol resilience item bank and short form.	to describe the development and psychometric properties of the spinal cord injury--quality of life (sci-qol) resilience item bank and short form.	26010971
measuring positive affect and well-being after spinal cord injury: development and psychometric characteristics of the sci-qol positive affect and well-being bank and short form.	to develop an item response theory (irt)-calibrated spinal cord injury (sci)-specific positive affect and well-being (pawb) item bank with flexible options for administration.	26010970
measuring grief and loss after spinal cord injury: development, validation and psychometric characteristics of the sci-qol grief and loss item bank and short form.	to develop an item response theory (irt) calibrated grief and loss item bank as part of the spinal cord injury--quality of life (sci-qol) measurement system.	26010969
measuring depression after spinal cord injury: development and psychometric characteristics of the sci-qol depression item bank and linkage with phq-9.	to develop a calibrated spinal cord injury-quality of life (sci-qol) item bank, computer adaptive test (cat), and short form to assess depressive symptoms experienced by individuals with sci, transform scores to the patient reported outcomes measurement information system (promis) metric, and create a crosswalk to the patient health questionnaire (phq)-9.	26010968
measuring psychological trauma after spinal cord injury: development and psychometric characteristics of the sci-qol psychological trauma item bank and short form.	to describe the development and psychometric properties of the sci-qol psychological trauma item bank and short form.	26010967
measuring anxiety after spinal cord injury: development and psychometric characteristics of the sci-qol anxiety item bank and linkage with gad-7.	to develop a calibrated item bank and computer adaptive test to assess anxiety symptoms in individuals with spinal cord injury (sci), transform scores to the patient reported outcomes measurement information system (promis) metric, and create a statistical linkage with the generalized anxiety disorder (gad)-7, a widely used anxiety measure.	26010966
development and psychometric characteristics of the sci-qol pressure ulcers scale and short form.	to develop a self-reported measure of the subjective impact of pressure ulcers on health-related quality of life (hrqol) in individuals with spinal cord injury (sci) as part of the sci quality of life (sci-qol) measurement system.	26010965
development and psychometric characteristics of the sci-qol bladder management difficulties and bowel management difficulties item banks and short forms and the sci-qol bladder complications scale.	to describe the development and psychometric properties of the spinal cord injury--quality of life (sci-qol) bladder management difficulties and bowel management difficulties item banks and bladder complications scale.	26010964
methodology for the development and calibration of the sci-qol item banks.	to develop a comprehensive, psychometrically sound, and conceptually grounded patient reported outcomes (pro) measurement system for individuals with spinal cord injury (sci).	26010963
overview of the spinal cord injury--quality of life (sci-qol) measurement system.	the spinal cord injury--quality of life (sci-qol) measurement system was developed to address the shortage of relevant and psychometrically sound patient reported outcome (pro) measures available for clinical care and research in spinal cord injury (sci) rehabilitation. using a computer adaptive testing (cat) approach, the sci-qol builds on the patient reported outcomes measurement information system (promis) and the quality of life in neurological disorders (neuro-qol) initiative. this initial ...	26010962
shared epitope-antagonistic ligands: a new therapeutic strategy in mice with erosive arthritis.	the mechanisms underlying bone damage in rheumatoid arthritis (ra) are incompletely understood. we recently identified the shared epitope (se), an hla-drb1-coded 5-amino acid sequence motif carried by the majority of ra patients as a signal transduction ligand that interacts with cell surface calreticulin and accelerates osteoclast (oc)-mediated bone damage in collagen-induced arthritis (cia). given the role of the se/calreticulin pathway in arthritis-associated bone damage, we sought to determi ...	25892196
strategies for managing aortoiliac occlusions: access, treatment and outcomes.	treatment of severe aortoiliac disease has dramatically evolved from a dependence on open aortobifemoral grafting to hybrid and endovascular only approaches. open surgery has been the gold standard treatment of severe aortoiliac disease with excellent patency rates, but with increased length of stay and major complications. in contrast, endovascular interventions can successfully treat almost any lesion with decreased risk, compared to open surgery. although primary patency rates remain inferior ...	25907618
"to-and-fro" waveform in the diagnosis of arterial pseudoaneurysms.	medical ultrasound imaging with doppler plays an essential role in the diagnosis of vascular disease. this study intended to review the clinical use of "to-and-fro" waveform at duplex doppler ultrasonography (ddu) in the diagnosis of pseudoaneurysms in the arterial vessels of upper and lower extremities, abdominal aorta, carotid and vertebral arteries as well as to review our personal experiences of "to-and-fro" waveform at ddu also. after receiving institutional review board approval, an inclus ...	26029351
a longitudinal investigation of race, socioeconomic status, and psychosocial mediators of allostatic load in midlife women: findings from the study of women's health across the nation.	this research sought to assess racial and socioeconomic status (ses) differences in level and change in allostatic load (al) over time in midlife women and to test whether psychosocial factors mediate these relationships. these factors were discrimination, perceived stress, and hostility.	25886828
in vivo activation of the sk channel in the spinal cord reduces the nmda receptor antagonist dose needed to produce antinociception in an inflammatory pain model.	n-methyl-d-aspartate receptor (nmdar) antagonists have been shown to reduce mechanical hypersensitivity in animal models of inflammatory pain. however, their clinical use is associated with significant dose-limiting side effects. small-conductance ca-activated k channels (sk) have been shown to modulate nmdar activity in the brain. we demonstrate that in vivo activation of sk channels in the spinal cord can alleviate mechanical hypersensitivity in a rat model of inflammatory pain. intrathecal (i ...	25734988
negative relational schemas predict the trajectory of coercive dynamics during early childhood.	coercive family processes are germane to the development of problem behaviors in early childhood, yet the cognitive and affective underpinnings are not well understood. we hypothesized that one antecedent of early coercive interactions is the caregiver's implicit affective attitudes toward the child, which in this article are termed relational schemas. relational schemas have previously been linked to coercion and problem behaviors, but there has yet to be an examination of the association betwe ...	25208813
the empathy and systemizing quotient: the psychometric properties of the dutch version and a review of the cross-cultural stability.	the 'empathy quotient' (eq) and 'systemizing quotient' (sq) are used worldwide to measure people's empathizing and systemizing cognitive styles. this study investigates the psychometric properties of the dutch eq and sq in healthy participants (n = 685), and high functioning males with autism spectrum disorder (n = 42). factor analysis provided support for three subscales of the abridged 28-item eq: cognitive empathy, emotional empathy and social skills. overall, the dutch eq and sq appeared rel ...	25911303
the lidocaine metabolite n-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain.	glycine transporter 1 (glyt1) plays a crucial role in regulating extracellular glycine concentrations and might thereby constitute a new drug target for the modulation of glycinergic inhibition in pain signaling. consistent with this view, inhibition of glyt1 has been found to induce antinociceptive effects in various animal pain models. we have shown previously that the lidocaine metabolite n-ethylglycine (eg) reduces glyt1-dependent glycine uptake by functioning as an artificial substrate for ...	25932687
a person-centered approach to studying the linkages among parent-child differences in cultural orientation, supportive parenting, and adolescent depressive symptoms in chinese american families.	this longitudinal study examined whether supportive parenting mediates relations between parent- child differences in cultural orientation (generational dissonance) and depressive symptoms with a sample of 451 first and second generation chinese american parents and adolescents (12-15 years old at time 1). using a person-centered approach, meaningful typologies of cultural orientation were derived for fathers, mothers, and adolescents. overall, results provided support, though qualified, for the ...	20725611
therapeutic blockade of t-cell antigen receptor signal transduction and costimulation in autoimmune disease.	cd4+ t-cell-mediated autoimmune diseases are initiated and maintained by the presentation of self-antigen by antigen-presenting cells (apcs) to self-reactive cd4+ t-cells. according to the two-signal hypothesis, activation of a naive antigen-specific cd4+ t-cell requires stimulation of both the t-cell antigen receptor (signal 1) and costimulatory molecules such as cd28 (signal 2). to date, the majority of therapies for autoimmune diseases approved by the food and drug administration primarily fo ...	19065796
occurrences and sources of differential item functioning (dif) in patient-reported outcome measures: description of dif methods, and review of measures of depression, quality of life and general health.	examination of the equivalence of measures involves several levels, including conceptual equivalence of meaning, as well as quantitative tests of differential item functioning (dif). the purpose of this review is to examine dif in patient-reported outcomes. reviewed were measures of self-reported depression, quality of life (qol) and general health. most measures of depression contained large amounts of dif, and the impact of dif at the scale level was typically sizeable. the studies of qol and ...	20165561
factorial invariance and the specification of second-order latent growth models.	latent growth modeling has been a topic of intense interest during the past two decades. most theoretical and applied work has employed first-order growth models, in which a single manifest variable serves as indicator of trait level at each time of measurement. in the current paper, we concentrate on issues regarding second-order growth models, which have multiple indicators at each time of measurement. with multiple indicators, tests of factorial invariance of parameters across times of measur ...	20046801
parentally bereaved children's grief: self-system beliefs as mediators of the relations between grief and stressors and caregiver-child relationship quality.	we investigated whether 3 self-system beliefs--fear of abandonment, coping efficacy, and self-esteem--mediated the relations between stressors and caregiver-child relationship quality and parentally bereaved youths' general grief and intrusive grief thoughts. cross-sectional (n = 340 youth) and longitudinal (n = 100 youth) models were tested. in the cross-sectional model, fear of abandonment mediated the effects of stressors and relationship quality on both measures of grief and coping efficacy ...	18924290
an empirical evaluation of the use of fixed cutoff points in rmsea test statistic in structural equation models.	this article is an empirical evaluation of the choice of fixed cutoff points in assessing the root mean square error of approximation (rmsea) test statistic as a measure of goodness-of-fit in structural equation models. using simulation data, the authors first examine whether there is any empirical evidence for the use of a universal cutoff, and then compare the practice of using the point estimate of the rmsea alone versus that of using it jointly with its related confidence interval. the resul ...	19756246
predicting genetic loading from symptom patterns in obsessive- compulsive disorder: a latent variable analysis.	some symptom dimensions in obsessive-compulsive disorder (ocd) patients have a familial and putative genetic foundation, based on replicated findings in studies of sib-pairs with ocd. however, these symptom dimensions are all from exploratory factor analyses of yale-brown obsessive-compulsive scale symptom checklist ratings based on non-empirically derived symptom categories, rather than individual symptoms.	18729144
cellular and molecular mechanisms of fibrosis.	fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen. fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury. although current treatments for fibrotic diseases such as idiopathic pulmonary fibrosis, liver cirrhosis, ...	18161745
pain catastrophizing scale for francophone adolescents: a preliminary validation.	in adults, it is well known that high levels of pain catastrophizing are related to increased pain and disability as well as to heightened anxiety and depression. however, due to the lack of a measure of pain catastrophizing adapted for francophone adolescents, little is known about the role of catastrophizing in this population.	18301812
deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion.	deguelin is a nature-derived chemopreventive drug. endothelial progenitor cells (epcs) are bone-marrow (bm)-derived key components to induce new blood vessels in early tumorigenesis and metastasis. here we determined whether deguelin inhibits epc function in vitro and in vivo at doses not affecting cancer cell apoptosis. deguelin significantly reduced the number of epc colony forming units of bm-derived c-kit+/sca-1+ mononuclear cells (mncs), proliferation, migration, and adhesion to endothelial ...	26078334
screening current and future diagnosis of psychiatric disorders using the revised drug use screening inventory.	the revised drug use screening inventory (dusi-r) is a valid and reliable self-report questionnaire used for quantifying problems that frequently precede and co-occur with substance abuse. the present investigation determined whether the dusi-r's items can be aggregated into scales that implicate current and future psychiatric disorders. scales were derived to screen for attention deficit, conduct, antisocial, anxiety, depression, and substance use disorders in a longitudinally tracked cohort of ...	18821459
a model-based cluster analysis approach to adolescent problem behaviors and young adult outcomes.	data from a community-based sample of 1,126 10th- and 11th-grade adolescents were analyzed using a model-based cluster analysis approach to empirically identify heterogeneous adolescent subpopulations from the person-oriented and pattern-oriented perspectives. the model-based cluster analysis is a new clustering procedure to investigate population heterogeneity utilizing finite mixture multivariate normal densities and accordingly to classify subpopulations using more rigorous statistical proced ...	18211739
understanding mother-adolescent conflict discussions: concurrent and across-time prediction from youths' dispositions and parenting.	adolescence is often thought of as a period during which the quality of parent-child interactions can be relatively stressed and conflictual. there are individual differences in this regard, however, with only a modest percent of youths experiencing extremely conflictual relationships with their parents. nonetheless, there is relatively little empirical research on factors in childhood or adolescence that predict individual differences in the quality of parent-adolescent interactions when dealin ...	18702792
a cognitive cascade in infancy: pathways from prematurity to later mental development.	using data from a longitudinal study of preterms and full-terms, the present study examined the structure of infant cognition at 12 months, the extent to which five 12-month abilities (attention, speed, recognition, recall, and representational competence) mediated the relation from prematurity to mental development at 2 - 3 years, and how continuity and change in infant information processing from 7 to 12 months affected later outcome. the results indicated that 12-month measures of infant info ...	19122757
development and validation of a principal implementation practices measure: the principal implementation questionnaire.	measurement of principal implementation behaviors has proved difficult to researchers in educational leadership due to a lack of consensus on the operational definitions of leadership constructs. the principal implementation questionnaire (piq) was developed and validated with the intention of providing clarity in the assessment of principal leadership behaviors in the implementation of effective reading programs. constructs were operationally defined within the context of the population of inte ...	26366043
cannabinoids in health and disease.	cannabis sativa l. preparations have been used in medicine for millenia. however, concern over the dangers of abuse led to the banning of the medicinal use of marijuana in most countries in the 1930s. only recently, marijuana and individual natural and synthetic cannabinoid receptor agonists and antagonists, as well as chemically related compounds, whose mechanism of action is still obscure, have come back to being considered of therapeutic value. however, their use is highly restricted. despite ...	18286801
an investigation of a measure of twins' equal environments.	the equal environments assumption, which holds that trait-relevant environments are equally correlated among monozygotic (mz) and dizygotic (dz) twin pairs, is essential to twin designs. violations of this assumption could lead to biased parameter estimates in twin models. a variety of methods and measures have been used to test this assumption. no studies to date have evaluated the measurement invariance of such items or examined the distribution of the underlying equal environments trait. the ...	18179396
culture, method, and the content of self-concepts: testing trait, individual-self-primacy, and cultural psychology perspectives.	three theoretical perspectives on cultural universals and differences in the content of self-concepts were tested in individualistic (united states, n = 178; australia, n = 112) and collectivistic (mexico, n = 157; philippines, n = 138) cultures, using three methods of self-concept assessment. support was found for both trait perspectives and the individual-self-primacy hypothesis. in contrast, support for cultural psychology hypotheses was limited because traits and other personal attributes we ...	19050737
polarizable atomic multipole solutes in a generalized kirkwood continuum.	the generalized born (gb) model of continuum electrostatics is an analytic approximation to the poisson equation useful for predicting the electrostatic component of the solvation free energy for solutes ranging in size from small organic molecules to large macromolecular complexes. this work presents a new continuum electrostatics model based on kirkwood's analytic result for the electrostatic component of the solvation free energy for a solute with arbitrary charge distribution. unlike gb, whi ...	26636202
measuring dimensions of body connection: body awareness and bodily dissociation.	this study aimed to test the preliminary psychometric properties of the scale of body connection (sbc), a 20-item self-report measure, designed to assess body awareness and bodily dissociation in mind-body intervention research.	18047441
decay accelerating factor can control t cell differentiation into ifn-gamma-producing effector cells via regulating local c5a-induced il-12 production.	a newly recognized link between the complement system and adaptive immunity is that decay accelerating factor (daf), a cell surface c3/c5 convertase regulator, exerts control over t cell responses. extending these results, we show that cultures of marilyn tcr-transgenic t cells stimulated with daf-deficient (daf1(-/-)) apcs produce significantly more il-12, c5a, and ifn-gamma compared with cultures containing wild-type apcs. daf-regulated il-12 production and subsequent t cell differentiation in ...	17947652
linking antisocial behavior, substance use, and personality: an integrative quantitative model of the adult externalizing spectrum.	antisocial behavior, substance use, and impulsive and aggressive personality traits often co-occur, forming a coherent spectrum of personality and psychopathology. in the current research, the authors developed a novel quantitative model of this spectrum. over 3 waves of iterative data collection, 1,787 adult participants selected to represent a range across the externalizing spectrum provided extensive data about specific externalizing behaviors. statistical methods such as item response theory ...	18020714
dysfunctional beliefs and attitudes about sleep (dbas): validation of a brief version (dbas-16).	sleep related cognitions (e.g., faulty beliefs and appraisals, unrealistic expectations, perceptual and attention bias) play an important role in perpetuating insomnia. this paper presents new psychometric data on an abbreviated version of the dysfunctional beliefs and attitudes about sleep scale (dbas-16), a 16-item self-report measure designed to evaluate a subset of those sleep related cognitions.	18041487
yale university school of medicine: 2007 student thesis abstracts.		18170929
the lupus-related lmb3 locus contains a disease-suppressing coronin-1a gene mutation.	here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting coronin-1a gene. this mutation was associated with developmental and functional alterations in t cells including reduced migration, survival, activation, and ca2+ flux. t-dependent humoral responses were impaired, but no intrinsic b cell defects were detected. by transfer of t cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the coro1a(lm ...	18199416