Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| measuring self-efficacy to use vaginal microbicides: the microbicide use self-efficacy instrument. | objectives to evaluate the psychometric properties of the microbicide use self-efficacy (muse) instrument and to examine correlates of self-efficacy to use vaginal microbicides among a sample of racially and ethnically diverse women living in the north-eastern united states. | 0 | 23806676 |
| medical tourism in malaysia: prospect and challenges. | tourism, combined with the phrase medical, seems to be a new form of tourism which has gained huge popularity in recent decades. though, a number of literatures available with regard to the tourism industry and the competitiveness of the destination, however, the major aspects which determine the satisfaction of medical tourists are hardly focused specifically on malaysia. there is a lack of empirical evidence in this area of study which needs to be bridged. hence, this study aimed at investigat ... | 0 | 26056632 |
| a latent class approach to examining forms of peer victimization. | there is growing interest in gender differences in the experience of various forms of peer victimization; however, much of the work to date has used traditional variable-centered approaches by focusing on scales or individual forms of victimization in isolation. the current study explored whether there were discrete groups of adolescents who experience distinct forms of peer victimization by bullying (e.g., physical, verbal, relational) among middle and high school-age youth, and whether members ... | 0 | 25414522 |
| idiopathic pulmonary fibrosis: the current status of its epidemiology, diagnosis, and treatment in china. | idiopathic pulmonary fibrosis (ipf) is a type of intractable and rare disease, and its epidemiology in china is still unclear. the diagnosis and treatment of ipf has received considerable attention and two editions of guidelines on ipf diagnosis and treatment have been published by the chinese society of respiratory diseases. treatment of ipf with traditional chinese medicine (tcm) has been widely investigated in china and several types of tcm extracts are reported to be effective in animal mode ... | 0 | 25343109 |
| efficacy and safety of a unique enteric-coated bicarbonate-buffered pancreatic enzyme replacement therapy in children and adults with cystic fibrosis. | pancreatic enzyme replacement therapy (pert) is used to treat exocrine pancreatic insufficiency in cystic fibrosis. | 0 | 25210613 |
| reliability, validity, and associations with sexual behavior among ghanaian teenagers of scales measuring four dimensions relationships with parents and other adults. | little research has been done on the social contexts of adolescent sexual behaviors in sub-saharan africa. as part of a longitudinal cohort study (n=1275) of teenage girls and boys in two ghanaian towns, interviewers administered a 26 item questionnaire module intended to assess four dimensions of youth-adult relationships: monitoring conflict, emotional support, and financial support. confirmatory factor and traditional psychometric analyses showed the four scales to be reliable. known-groups c ... | 0 | 25821286 |
| study design considerations for evaluating the efficacy and safety of pancreatic enzyme replacement therapy in patients with cystic fibrosis. | in 2006, the us fda issued a 'guidance for industry' regarding submission of new drug applications for pancreatic enzyme replacement therapy (pert) products. five oral delayed-release pert products have been approved by the fda, and several others are under development and/ or evaluation for new drug application submission. we present in this paper recommendations of the cystic fibrosis foundation's cystic fibrosis (cf) therapeutics development network and data safety monitoring board regarding ... | 0 | 25132954 |
| psychological health of military children: longitudinal evaluation of a family-centered prevention program to enhance family resilience. | family-centered preventive interventions have been proposed as relevant to mitigating psychological health risk and promoting resilience in military families facing wartime deployment and reintegration. this study evaluates the impact of a family-centered prevention program, families overcoming under stress family resilience training (focus), on the psychological adjustment of military children. two primary goals include (1) understanding the relationships of distress among family members using ... | 0 | 23929043 |
| vii. nih toolbox cognition battery (cb): factor structure for 3 to 15 year olds. | confirmatory factor analysis was used the evaluate the dimensional structure underlying the nih toolbox cognition battery (cb) and the measures chosen to serve as concurrent validity criteria for the nih toolbox cb. these results were used to evaluate the convergent and discriminant validity of the cb in children ranging from 3 to 15 years of age. results were evaluated separately for a 3- to 6-year-old group and a 8- to 15-year-old group because different validation measures were used in these ... | 0 | 23952205 |
| deconstructing the externalizing spectrum: growth patterns of overt aggression, covert aggression, oppositional behavior, impulsivity/inattention, and emotion dysregulation between school entry and early adolescence. | the purpose of this study was to determine whether five subcomponents of children's externalizing behavior showed distinctive patterns of long-term growth and predictive correlates. we examined growth in teachers' ratings of overt aggression, covert aggression, oppositional defiance, impulsivity/inattention, and emotion dysregulation across three developmental periods spanning kindergarten through grade 8 (ages 5-13 years). we also determined whether three salient background characteristics, fam ... | 0 | 23880394 |
| rapid ultrasonic stimulation of inflamed tissue with diagnostic intent. | previous studies have observed that individual pulses of intense focused ultrasound (ifu) applied to inflamed and normal tissue can generate sensations, where inflamed tissue responds at a lower intensity than normal tissue. it was hypothesized that successively applied ifu pulses will generate sensation in inflamed tissue at a lower intensity and dose than application of a single ifu pulse. this hypothesis was tested using an animal model of chronic inflammatory pain, created by injecting an ir ... | 0 | 23927192 |
| factor structure of measures of anxiety and depression symptoms in african american youth. | previous research has suggested that the factor structure of anxiety measures is different in african american samples compared to majority population samples. however, these findings may be due to misuse of analytic methods rather than meaningful differences in the underlying presentation of anxiety. to address this, we examined the factor structure of two measures of child anxiety: the revised children's anxiety and depression scale and the multidimensional anxiety scale for children in a samp ... | 0 | 23224837 |
| reading skill components and impairments in middle school struggling readers. | this study investigated how measures of decoding, fluency, and comprehension in middle school students overlap with one another, whether the pattern of overlap differs between struggling and typical readers, and the relative frequency of different types of reading difficulties. the 1,748 sixth, seventh, and eighth grade students were oversampled for struggling readers (n = 1,025) on the basis of the state reading comprehension proficiency measure. multigroup confirmatory factor analyses showed p ... | 0 | 24000271 |
| angiogenesis in rheumatoid arthritis is fostered directly by toll-like receptor 5 ligation and indirectly through interleukin-17 induction. | to examine the impact of toll-like receptor 5 (tlr-5) on endothelial cell function in rheumatoid arthritis (ra) and vascularization in collagen-induced arthritis (cia). | 0 | 23666857 |
| single and multiple ability estimation in the sem framework: a non-informative bayesian estimation approach. | latent variable models with many categorical items and multiple latent constructs result in many dimensions of numerical integration, and the traditional frequentist estimation approach, such as maximum likelihood (ml), tends to fail due to model complexity. in such cases, bayesian estimation with diffuse priors can be used as a viable alternative to ml estimation. the present study compares the performance of bayesian estimation to ml estimation in estimating single or multiple ability factors ... | 0 | 24659828 |
| investigating factorial invariance of latent variables across populations when manifest variables are missing completely. | difficulties arise in multiple-group evaluations of factorial invariance if particular manifest variables are missing completely in certain groups. ad hoc analytic alternatives can be used in such situations (e.g., deleting manifest variables), but some common approaches, such as multiple imputation, are not viable. at least 3 solutions to this problem are viable: analyzing differing sets of variables across groups, using pattern mixture approaches, and a new method using random number generatio ... | 0 | 24019738 |
| artemin, a glial cell line-derived neurotrophic factor family member, induces trpm8-dependent cold pain. | chronic pain associated with injury or disease can result from dysfunction of sensory afferents whereby the threshold for activation of pain-sensing neurons (nociceptors) is lowered. neurotrophic factors control nociceptor development and survival, but also induce sensitization through activation of their cognate receptors, attributable, in part, to the modulation of ion channel function. thermal pain is mediated by channels of the transient receptor potential (trp) family, including the cold an ... | 0 | 23884957 |
| trkb.t1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways. | spinal cord injury (sci) frequently causes severe, persistent central neuropathic pain that responds poorly to conventional pain treatments. brain-derived neurotrophic factor (bdnf) signaling appears to contribute to central sensitization and nocifensive behaviors in certain animal models of chronic pain through effects mediated in part by the alternatively spliced truncated isoform of the bdnf receptor tropomyosin-related kinase b.t1 (trkb.t1). mechanisms linking trkb.t1 to sci-induced chronic ... | 0 | 23884949 |
| measurement properties of the motivation for youth treatment scale with a residential group home population. | 0 | 24288450 | |
| a novel mcl1 variant inhibits apoptosis via increased bim sequestration. | members of the bcl-2 protein family are frequently deregulated in tumors as they critically control cell death induction in mammalian cells. alterations of these proteins may cause resistance to chemotherapy-induced cell death and immune responses. by serendipity we cloned a variant of the anti-apoptotic bcl2-family member myeloid cell leukemia-1 (mcl1) from human neuroblastoma and leukemia cells. this mcl1l variant lacks a 45 bp sequence that codes for 15 highly conserved amino acids ranging fr ... | 0 | 23872733 |
| pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model. | bladder dysfunction is common in multiple sclerosis (ms) but little is known of its pathophysiology. we show that mice with experimental autoimmune encephalomyelitis (eae), a ms model, have micturition dysfunction and altered expression of genes associated with bladder mechanosensory, transduction and signaling systems including pannexin 1 (panx1) and gja1 (encoding connexin43, referred to here as cx43). eae mice with panx1 depletion (panx1(-/-)) displayed similar neurological deficits but lesse ... | 0 | 23827947 |
| coronary computed tomography angiography with 320-row detector and using the aidr-3d: initial experience. | coronary computed tomography angiography (coronary cta) is a powerful non-invasive imaging method to evaluate coronary artery disease. nowadays, coronary cta estimated effective radiation dose can be dramatically reduced using state-of-the-art scanners, such as 320-row detector ct (320-ct), without changing coronary cta diagnostic accuracy. to optimize and further reduce the radiation dose, new iterative reconstruction algorithms were released recently by several ct manufacturers, and now they a ... | 0 | 24136773 |
| injection drug users' involvement in drug economy: dynamics of sociometric and egocentric social networks. | the purpose of this analysis was to examine the effect of social network cohesiveness on drug economy involvement, and to test whether this relationship is mediated by drug support network size in a sample of active injection drug users. involvement in the drug economy was defined by self-report of participation in at least one of the following activities: selling drugs, holding drugs or money for drugs, providing street security for drug sellers, cutting/packaging/cooking drugs, selling or rent ... | 0 | 25309015 |
| rotated superficial femoral artery patch after common femoral artery endarterectomy. | 0 | 23838514 | |
| evaluation of the effects of caffeic acid phenethyl ester on prostaglandin e2 and two key cytokines involved in bleomycin-induced pulmonary fibrosis. | pulmonary fibrosis (pf) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. it is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of pf in animal models and possibly in humans. caffeic acid phenethyl ester (cape), an active component of propolis, has numerous biological effects. in the present study, the main objective was to investigate the ... | 0 | 23997916 |
| alcohol use disorders among substance dependent women on temporary assistance with needy families: more information for diagnostic modifications for dsm-5. | while modifications to alcohol use disorder (aud) criteria are proposed for dsm-5, examination of the criteria's performance among highly vulnerable populations is lacking. this study determined the dimensionality and rank order severity of the dsm-iv aud criteria among temporary assistance for needy families (tanf) recipients with high rates of chemical dependency and co-morbid mental health disorders. | 0 | 23795881 |
| multisite study of new autism diagnostic interview-revised (adi-r) algorithms for toddlers and young preschoolers. | using two independent datasets provided by national institute of health funded consortia, the collaborative programs for excellence in autism and studies to advance autism research and treatment (n = 641) and the national institute of mental health (n = 167), diagnostic validity and factor structure of the new autism diagnostic interview (adi-r) algorithms for toddlers and young preschoolers were examined as a replication of results with the 2011 michigan sample (kim and lord in j autism dev dis ... | 0 | 23114567 |
| combinatorial effect of metformin and lovastatin impedes t-cell autoimmunity and neurodegeneration in experimental autoimmune encephalomyelitis. | multiple sclerosis (ms) is an incurable central nervous system (cns) demyelinating disease affecting several million people worldwide. due to the multifactorial and complex pathology of ms, fda approved drugs often show limited efficacy inpatients. we earlier documented that both lovastatin (cholesterol lowering drug) and metformin (anti-diabetic drug) attenuate experimental autoimmune encephalomyelitis (eae), a widely used model of ms via different mechanisms of action. since combination therap ... | 0 | 24324917 |
| profile of circulatory metabolites in a relapsing-remitting animal model of multiple sclerosis using global metabolomics. | multiple sclerosis (ms) is a chronic inflammatory and demyelinating disease of the cns. although, ms is well characterized in terms of the role played by immune cells, cytokines and cns pathology, nothing is known about the metabolic alterations that occur during the disease process in circulation. recently, metabolic aberrations have been defined in various disease processes either as contributing to the disease, as potential biomarkers, or as therapeutic targets. thus in an attempt to define t ... | 0 | 24273690 |
| the 8th korea-japan joint meeting for vascular surgery. | 0 | 23825512 | |
| a splice variant in krt71 is associated with curly coat phenotype of selkirk rex cats. | one of the salient features of the domestic cat is the aesthetics of its fur. the selkirk rex breed is defined by an autosomal dominant woolly rexoid hair (adwh) abnormality that is characterized by tightly curled hair shafts. a genome-wide case - control association study was conducted using 9 curly coated selkirk rex and 29 controls, including straight-coated selkirk rex, british shorthair and persian, to localize the selkirk autosomal dominant rexoid locus (sadre). although the control cats w ... | 0 | 23770706 |
| developmental and individual differences in chinese writing. | the goal of the present study was to examine the generalizability of a model of the underlying dimensions of written composition across writing systems (chinese mandarin vs. english) and level of writing skill. a five-factor model of writing originally developed from analyses of 1st and 4th grade english writing samples was applied to chinese writing samples obtained from 4th and 7th grade students. confirmatory factor analysis was used to compare the fits of alternative models of written compos ... | 0 | 26038631 |
| mutual amide prodrug of etodolac-glucosamine: synthesis, characterization and pharmacological screening. | etodolac, a nonsteroidal antiinflammatory drug, widely used in arthritis is associated with gastric ulceration and irritation due to presence of free carboxylic group. the current investigation reports synthesis of mutual amide prodrug of etodolac by masking free carboxylic group with glucosamine, a nutritional supplement for treatment of arthritis. confirmation and characterization of the structure of the synthesized prodrug done by elemental and spectroscopy analysis, melting point, determinat ... | 0 | 24302794 |
| histological assessment of intra-articular versus intra-peritoneal betamethasone l.a on tempromandibular joint arthritis in rat. | pain and dysfunction of the tempromandibular joint (tmj) are major clinical problems, especially, in arthritis. the aim of this study was to compare the effect of intra-articular (ia) versus intra-peritoneal (ip) injection of betamethasone long acting on tmj arthritis in rat. | 0 | 24130589 |
| immunosuppression by co-stimulatory molecules: inhibition of cd2-cd48/cd58 interaction by peptides from cd2 to suppress progression of collagen-induced arthritis in mice. | targeting co-stimulatory molecules to modulate the immune response has been shown to have useful therapeutic effects for autoimmune diseases. among the co-stimulatory molecules, cd2 and cd58 are very important in the early stages of generation of an immune response. our goal was to utilize cd2-derived peptides to modulate protein-protein interactions between cd2 and cd58, thereby modulating the immune response. several peptides were designed based on the structure of the cd58-binding domain of c ... | 0 | 23530775 |
| the prescribed opioids difficulties scale: a patient-centered assessment of problems and concerns. | chronic opioid therapy for chronic noncancer pain has increased dramatically in recent years. research on associated risks has typically focused on opioid abuse and dependence, and opioid misuse or aberrant drug use behaviors, but these risks have been defined from the providers' perspective. the aim of this article was to develop a psychometrically sound method for assessing difficulties patients attribute to chronic opioid therapy. | 0 | 20551723 |
| a new audience segmentation tool for african americans: the black identity classification scale. | many health communications target african americans in an attempt to remediate race-based health disparities. such materials often assume that african americans are culturally homogeneous; however, research indicates that african americans are heterogeneous in their attitudes, behaviors, and beliefs. the black identity classification scale (bics) was designed as a telephone-administered tool to segment african american audiences into 16 ethnic identity types. the bics was pretested using focus g ... | 0 | 20677057 |
| attentional and emotional mechanisms of pain processing and their related factors: a structural equations approach. | it is known that maladaptive attentional and emotional mechanisms of pain processing - as indicated by constructs such as pain hypervigilance, pain-related anxiety and pain catastrophizing - play an important role in the development and maintenance of chronic pain conditions. however, little is known to date about the potential risk factors for these forms of maladaptive processing. the aim of the present study was to shed more light on this issue. a very comprehensive set of predictor variables ... | 0 | 20808968 |
| development of a promis item bank to measure pain interference. | this paper describes the psychometric properties of the promis-pain interference (promis-pi) bank. an initial candidate item pool (n=644) was developed and evaluated based on the review of existing instruments, interviews with patients, and consultation with pain experts. from this pool, a candidate item bank of 56 items was selected and responses to the items were collected from large community and clinical samples. a total of 14,848 participants responded to all or a subset of candidate items. ... | 0 | 20554116 |
| foxp3⁺ regulatory cd4 t cells control the generation of functional cd8 memory. | during the primary immune response, cd8 memory emerges from an environment of strong immune activation. the foxp3(+) regulatory cd4 t-cell subset (treg) is known as a key suppressive component of the immune system. here we report that tregs are required for the generation of functional cd8 memory. in the absence of tregs during priming, the resulting memory cells proliferate poorly and fail to differentiate into functional cytotoxic secondary effectors following antigen reactivation. we find tha ... | 0 | 22871805 |
| relations between parent psychopathology, family functioning, and adolescent problems in substance-abusing families: disaggregating the effects of parent gender. | the present study: (1) examined relations between parent psychopathology and adolescent internalizing problems, externalizing problems, and substance use in substance-abusing families; and (2) tested family functioning problems as mediators of these relations. structural equation modeling was used to estimate the independent effects of parent psychopathology and family functioning problems by parent gender. participants included 242 parents in treatment for substance abuse and/or dependence and ... | 0 | 22392413 |
| antigen-specific transforming growth factor β-induced treg cells, but not natural treg cells, ameliorate autoimmune arthritis in mice by shifting the th17/treg cell balance from th17 predominance to treg cell predominance. | transferred cd4+cd25+foxp3+ treg cells can prevent autoimmune disease, but generally fail to ameliorate established disease. this study was undertaken to compare the effects of antigen-specific treg cells induced with interleukin-2 (il-2) and transforming growth factor β (tgfβ) ex vivo (induced treg [itreg] cells) to the effects of equivalent expanded thymus-derived natural treg (ntreg) cells on established collagen-induced arthritis (cia). | 0 | 22605463 |
| estimation of effective population size in the sapsaree: a korean native dog (canis familiaris). | effective population size (ne) is an important measure to understand population structure and genetic variability in animal species. the objective of this study was to estimate ne in sapsaree dogs using the information of rate of inbreeding and genomic data that were obtained from pedigree and the illumina caninesnp20 (20k) and caninehd (170k) beadchips, respectively. three snp panels, i.e. sap134 (20k), sap60 (170k), and sap183 (the combined panel from the 20k and 170k), were used to genotype 1 ... | 0 | 25049664 |
| belief in divine control, coping, and race/ethnicity among older women with breast cancer. | belief in divine control is often assumed to be fatalistic. however, the assumption has rarely been investigated in racial/ethnic minorities. | 0 | 22529040 |
| testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor m1 variation. | this study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor m1 (oprm1) genetic variation in the intergenerational transmission of alcohol use disorder (aud) symptoms while separating the "traitlike" components of aud symptoms from their age-specific manifestations at three ages from emerging adulthood (17-23 years) to adulthood (29-40 years). the results for males were consistent with genetically influenced peer selection mechanisms as mediators ... | 0 | 22781865 |
| susceptibility to autoimmune myocarditis is associated with intrinsic differences in cd4(+) t cells. | a.sw and b10.s mice share the same major histocompatibility complex (mhc) haplotype (h-2(s)). however, a.sw mice are susceptible to experimental autoimmune myocarditis (eam) and develop severe disease after immunization with myosin, whereas b10.s mice are resistant. we found that naive a.sw mice have intrinsically increased total cd4(+) t cell counts and increased proportions of cd4(+) t cells in their spleens compared to b10.s mice. among total cd4(+) t cells, naive a.sw mice have a lower relat ... | 0 | 22774982 |
| k/b×n serum transfer arthritis is delayed and less severe in leukaemia inhibitory factor (lif)-deficient mice. | this study is investigating the role of leukaemia inhibitory factor (lif) in the development of inflammation and joint damage in the mouse k/b×n serum transfer arthritis model. lif knock-out (lif(-/-)) mice were generated by mating heterozygote females (lif(+/-)) with heterozygote males. arthritis was induced in 8-20-week-old lif knock-out mice (lif(-/-)) by intraperitoneal injection of pooled k/b×n sera (50 µl) on days 0 and 2. clinical disease was scored daily for 6 days. safranin-o and haemat ... | 0 | 22774981 |
| graft-versus-host disease reduces regulatory t-cell migration into the tumour tissue. | the therapeutic principle of allogeneic haematopoietic cell transplantation (allo-hct) is based on an active donor immune system that eliminates host-derived tumour cells. we hypothesized that in addition to the alloantigen-driven anti-tumour response, disruption of the immunological microenvironment within the tumour is responsible for its elimination after allo-hct. we observed that induction of graft-versus-host disease (gvhd) significantly reduced the abundance of luc(+) foxp3(+) regulatory ... | 0 | 22681312 |
| research methods in child disaster studies: a review of studies generated by the september 11, 2001, terrorist attacks; the 2004 indian ocean tsunami; and hurricane katrina. | a comprehensive review of the design principles and methodological approaches that have been used to make inferences from the research on disasters in children is needed. | 0 | 24443635 |
| seizure localization using broadband eeg: comparison of conventional frequency activity, high-frequency oscillations, and infraslow activity. | in neocortical epilepsy, we showed that the seizure onset defined by ictal high-frequency oscillations (hfo: ≥ 70 hz) with subsequent evolution into slower frequency activity (i.e., hfos+) was smaller in spatial distribution than that defined by conventional frequency activity (1-70 hz), and that resection of hfo+ areas resulted in favorable seizure outcome. this study further investigates ictal broadband eeg in the same cohort of patients by examining the infraslow activity, including ictal bas ... | 0 | 22854764 |
| using genetic information to test causal relationships in cross-sectional data. | cross-sectional data from twins contain information that can be used to derive a test of causality between traits. this test of directionality is based upon the fact that genetic relationships between family members conform to an established structural pattern. in this paper we examine several common methods for empirically testing causality as well as several genetic models that we build on for the direction of causation (doc) model. we then discuss the mathematical components of the doc model ... | 0 | 23946557 |
| refining the phenotype of borderline personality disorder: diagnostic criteria and beyond. | borderline personality disorder (bpd) is a heterogeneous disorder, and previous analyses have parsed its phenotype in terms of subtypes or underlying traits. we refined the bpd construct by testing a range of latent variable models to ascertain whether bpd is composed of traits, latent classes, or both. we also tested whether subtypes of bpd could be distinguished by anger, aggressiveness, antisocial behavior, and mis-trustfulness, additional putative indicators drawn from kernberg's (1967, 1975 ... | 0 | 22823231 |
| factor analysis of positive and negative syndrome scale in schizophrenia: an exploratory study. | controversy persists with regard to how best we can categorize symptomatic dimension of schizophrenia. aim of the study was to compute factorial dimensions in indian subset of schizophrenic patients and to compare them with five factor pentagonal model extracted in western studies. | 0 | 23226846 |
| monoacylglycerol lipase - a target for drug development? | the endocannabinoid (ecb) system is involved in processes as diverse as control of appetite, perception of pain and the limitation of cancer cell growth and invasion. the enzymes responsible for ecb breakdown are attractive pharmacological targets, and fatty acid amide hydrolase inhibitors, which potentiate the levels of the ecb anandamide, are now undergoing pharmaceutical development. 'drugable' selective inhibitors of monoacylglycerol lipase, a key enzyme regulating the levels of the other ma ... | 0 | 22428756 |
| the pain and sleep questionnaire three-item index (psq-3): a reliable and valid measure of the impact of pain on sleep in chronic nonmalignant pain of various etiologies. | sleep disturbance is among the more common complaints reported by chronic pain patients. because pain-related sleep disturbance may serve as a marker for the assessment of responses to treatment for chronic pain, inclusion of a measure designed to assess the impact of pain on sleep in clinical trial protocols is important, if not necessary. measures typically used for this purpose lack scales specifically designed for the assessment of the impact of pain on sleep or are based on a single item. s ... | 0 | 22891194 |
| effect of pain management on immunization efficacy in mice. | immunization with complete freund adjuvant (cfa) or incomplete freund adjuvant (ifa) is commonly viewed as painful, yet rodents may not receive analgesics due to concerns that these drugs affect the desired immune responses. here we tested the hypothesis that pain associated with immunization with cfa or ifa in mice can be relieved without compromising the effectiveness of the immune response. after subcutaneous immunization in the leg with antigen in cfa or ifa, mice were assessed for signs of ... | 0 | 23043810 |
| genome analysis of bovine-mastitis-associated escherichia coli o32:h37 strain p4. | escherichia coli is a major pathogen of bovine intramammary infections. here we report the first draft of the genome sequence of the e. coli o32:h37 p4 strain, which is widely used in experimental bovine mastitis studies. | 0 | 22740662 |
| neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint. | many forms of arthritis are accompanied by significant chronic joint pain. this study was undertaken to investigate whether there is significant sprouting of sensory and sympathetic nerve fibers in the painful arthritic knee joint and whether nerve growth factor (ngf) drives this pathologic reorganization. | 0 | 22246649 |
| psychometric study of the aberrant behavior checklist in fragile x syndrome and implications for targeted treatment. | animal studies elucidating the neurobiology of fragile x syndrome (fxs) have led to multiple controlled trials in humans, with the aberrant behavior checklist-community (abc-c) commonly adopted as a primary outcome measure. a multi-site collaboration examined the psychometric properties of the abc-c in 630 individuals (ages 3-25) with fxs using exploratory and confirmatory factor analysis. results support a six-factor structure, with one factor unchanged (inappropriate speech), four modified (ir ... | 0 | 21972117 |
| gm-csf controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. | gm-csf (csf-2) is a critical cytokine for the in vitro generation of dendritic cells (dcs) and is thought to control the development of inflammatory dcs and resident cd103(+) dcs in some tissues. here we showed that in contrast to the current understanding, csf-2 receptor acts in the steady state to promote the survival and homeostasis of nonlymphoid tissue-resident cd103(+) and cd11b(+) dcs. absence of csf-2 receptor on lung dcs abrogated the induction of cd8(+) t cell immunity after immunizati ... | 0 | 22749353 |
| economic disadvantage and young children's emotional and behavioral problems: mechanisms of risk. | this study aimed to establish potential mechanisms through which economic disadvantage contributes to the development of young children's internalizing and externalizing problems. prospective data from fetal life to age 3 years were collected in a total of 2,169 families participating in the generation r study. the observed physical home environment, the provision of learning materials in the home, maternal depressive symptoms, parenting stress, and harsh disciplining practices were all analyzed ... | 0 | 22736330 |
| dyadic interaction: greater than the sum of its parts? | the study of dyadic interaction plays a major role in infancy research. to advance conceptually-informed measurement of dyadic interaction and integration across studies, we examined factor structure of individual parents' and infants' measures and dyadic measures from face-to-face interactions in two samples of 6-mo-old infants and their parents: mothers from a demographically heterogeneous sample (n = 164) and mothers and fathers (n = 156) from a caucasian middle-class sample. results suggeste ... | 0 | 24187518 |
| a nociceptive signaling role for neuromedin b. | here we used an array-based differential screen to uncover the expression of the neuropeptide neuromedin b (nmb) in the trigeminal ganglia of mice. double-labeling experiments reveal nmb is expressed in a subset of sensory neurons that colabel with calcitonin gene-related peptide and trpv1 suggestive of a role for nmb in nociception. indeed, administration of nmb antagonist greatly attenuates edema and nerve sensitization following stimulation of peripheral nerves with mustard oil, demonstrating ... | 0 | 22723708 |
| repeatable battery for assessment of neuropsychological status in early parkinson's disease. | adequate reliability and valid factor structure are prerequisites for appropriate use of a measure in a population. although the repeatable battery for assessment of neuropsychological status (rbans) has been used to examine cognition in parkinson's disease (pd), its reliability and factor structure have not been examined in this population. this study examined the reliability and factor structure of the rbans in participants with de novo pd recruited for two nih exploratory trials in parkinson' ... | 0 | 19452561 |
| engaging youth in food activism in new york city: lessons learned from a youth organization, health department, and university partnership. | research indicates that insufficient emphasis on community collaboration and partnership can thwart innovative community-driven work on the social determinants of health by local health departments. appreciating the importance of enhancing community participation, the new york city department of health and mental hygiene (dohmh) helped lead the development of the health equity project (hep), an intervention aimed at increasing the capacity of urban youth to identify and take action to reduce foo ... | 0 | 22696174 |
| over-expression of extracellular superoxide dismutase in mouse synovial tissue attenuates the inflammatory arthritis. | oxidative stress such as reactive oxygen species (ros) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. correlations between extracellular- superoxide dismutase (ec-sod) and inflammatory arthritis have been shown in several animal models of ra. however, there is a question whether the over-expression of ec-sod on arthritic joint also could suppress the progression of disease or not. in the present study, the effect on the sy ... | 0 | 22718219 |
| evidence for stopping mass drug administration for lymphatic filariasis in some, but not all local government areas of plateau and nasarawa states, nigeria. | an average of six annual rounds of ivermectin and albendazole were distributed in plateau and nasarawa states, nigeria, to eliminate lymphatic filariasis. from 2007 to 2008, population-based surveys were implemented in all 30 local government areas (lgas) of the two states to determine the prevalence of wuchereria bancrofti antigenemia to assess which lga mass drug administration (mda) could be halted. in total, 36,681 persons from 7,819 households were examined for filarial antigen as determine ... | 0 | 22855758 |
| characterization of unstable pentyn10 from enterotoxigenic escherichia coli (etec) o169:h41. | enterotoxigenic escherichia coli (etec) serotype o169:h41 has been an extremely destructive epidemic etec type worldwide. the strain harbors a large unstable plasmid that is regarded as responsible for its virulence, although its etiology has remained unknown. to examine its genetic background specifically on the unstable retention and responsibility in the unique adherence to epithelial cells and enterotoxin production, the complete sequence of a plasmid, pentyn10, purified from the serotype st ... | 0 | 26575107 |
| decomposing the relationship between anxiety sensitivity and alcohol use. | the misuse of alcohol is related to numerous detrimental health effects. research has determined anxiety sensitivity (as) to be a risk factor for problematic alcohol use. to date, no studies have investigated this relationship using a bifactor model of as. this study used a bifactor model to determine the effects of the general as factor and the cognitive, physical, and social concerns subfactors on alcohol-related outcomes. | 0 | 26562605 |
| myelin oligodendrocyte glycoprotein (mog35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice. | multiple sclerosis (ms), also known as disseminated sclerosis or encephalomyelitis disseminate, is an inflammatory disease in which myelin in the spinal cord and brain are damaged. il-32α is known as a critical molecule in the pathophysiology of immune-mediated chronic inflammatory disease such as rheumatoid arthritis, chronic pulmonary disease, and cancers. however, the role of il-32α on spinal cord injuries and demyelination is poorly understood. recently, we reported that the release of proin ... | 0 | 26564962 |
| inhibition of cell adhesion and immune responses in the mouse model of collagen-induced arthritis with a peptidomimetic that blocks cd2-cd58 interface interactions. | cd2 and cd58 are two important costimulatory molecules involved in generating the signal ii required for normal immune signaling. however, this interaction can be targeted to be of benefit in cases of abnormal immune signaling seen in autoimmune diseases. our objective in this study was to design a peptidomimetic (compound 7) based on a β-strand structure of the adhesion domain of cd2 protein to inhibit cd2-cd58 protein-protein interaction and its effect on immunomodulation in the collagen-induc ... | 0 | 26031942 |
| trauma coping self-efficacy: a context-specific self-efficacy measure for traumatic stress. | the psychometric properties of a trauma coping self-efficacy (cse-t) scale that assesses general trauma-related coping self-efficacy perceptions were assessed. | 0 | 26524542 |
| the correlation of symptoms, pulmonary function tests and exercise testing with high-resolution computed tomography in patients with idiopathic interstitial pneumonia in a tertiary care hospital in south india. | for the follow-up of patients with idiopathic interstitial pneumonias (iip), it is unclear which parameters of pulmonary function tests (pft) and exercise testing would correlate best with high-resolution computed tomography (hrct).. | 0 | 26664164 |
| developmental pathways from child maltreatment to adolescent marijuana dependence: examining moderation by fk506 binding protein 5 gene (fkbp5). | the current study examined the prospective association between child maltreatment and the development of substance use disorder in adolescence with the aim of investigating pathways underlying this relation, as well as genetic moderation of these developmental mechanisms. specifically, we tested whether youth who experienced maltreatment prior to age 8 were at risk for the development of marijuana dependence in adolescence by way of a childhood externalizing pathway and a childhood internalizing ... | 0 | 26535939 |
| plasma levels of interleukin-1 receptor antagonist (il1ra) predict radiographic progression of symptomatic knee osteoarthritis. | pro- and anti-inflammatory mediators, such as il-1β and il1ra, are produced by joint tissues in osteoarthritis (oa), where they may contribute to pathogenesis. we examined whether inflammatory events occurring within joints are reflected in plasma of patients with symptomatic knee osteoarthritis (skoa). | 0 | 26521737 |
| local joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis. | anti-citrullinated protein antibodies (acpas) are characteristic of rheumatoid arthritis (ra). however, their presence years before the onset of clinical ra is perplexing. although multiple putative citrullinated antigens have been identified, no studies have demonstrated the specific capacity of these antigens to initiate inflammatory arthritis. this study was undertaken to recapitulate the transition from preclinical to clinical ra and to demonstrate the capacity of local citrullination to fac ... | 0 | 26227989 |
| comparative safety of vaccine adjuvants: a summary of current evidence and future needs. | use of highly pure antigens to improve vaccine safety has led to reduced vaccine immunogenicity and efficacy. this has led to the need to use adjuvants to improve vaccine immunogenicity. the ideal adjuvant should maximize vaccine immunogenicity without compromising tolerability or safety. unfortunately, adjuvant research has lagged behind other vaccine areas such as antigen discovery, with the consequence that only a very limited number of adjuvants based on aluminium salts, monophosphoryl lipid ... | 0 | 26446142 |
| (positive) power to the child: the role of children's willing stance toward parents in developmental cascades from toddler age to early preadolescence. | in a change from the once-dominant view of children as passive in the parent-led process of socialization, children are now seen as active agents who can considerably influence that process. however, these newer perspectives typically focus on the child's antagonistic influence, due either to a difficult temperament or aversive, resistant, negative behaviors that elicit adversarial responses from the parent and lead to future coercive cascades in the relationship. children's capacity to act as r ... | 0 | 26439058 |
| bully/victim profiles' differential risk for worsening peer acceptance: the role of friendship. | study aims were to: (1) evaluate the association between bully/victim profiles, derived via latent profile analysis (lpa), and changes in peer acceptance from the fall to spring of 7(th) grade, and (2) investigate the likelihood of friendlessness, and the protective function of mutual friendship, among identified profiles. participants were 2,587 7(th) graders; peer nomination and rating-scale data were collected in the fall and spring. four profiles, including bullies, victims, bully-victims, a ... | 0 | 26309346 |
| brain circuits encoding reward from pain relief. | relief from pain in humans is rewarding and pleasurable. primary rewards, or reward-predictive cues, are encoded in brain reward/motivational circuits. while considerable advances have been made in our understanding of reward circuits underlying positive reinforcement, less is known about the circuits underlying the hedonic and reinforcing actions of pain relief. we review findings from electrophysiological, neuroimaging, and behavioral studies supporting the concept that the rewarding effect of ... | 0 | 26603560 |
| college students' perceptions of professor/instructor bullying: questionnaire development and psychometric properties. | this study developed and examined the psychometric properties of a newly formed measure designed to assess professor/instructor bullying, as well as teacher bullying occurring prior to college. additionally, prevalence of instructor bullying and characteristics related to victims of instructor bullying were examined. | 0 | 26151235 |
| gate control of mechanical itch by a subpopulation of spinal cord interneurons. | light mechanical stimulation of hairy skin can induce a form of itch known as mechanical itch. this itch sensation is normally suppressed by inputs from mechanoreceptors; however, in many forms of chronic itch, including alloknesis, this gating mechanism is lost. here we demonstrate that a population of spinal inhibitory interneurons that are defined by the expression of neuropeptide y::cre (npy::cre) act to gate mechanical itch. mice in which dorsal npy::cre-derived neurons are selectively abla ... | 0 | 26516282 |
| denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease. | some dry eye disease (ded) patients have sensitized responses to corneal stimulation, while others experience hypoalgesia. many patients have normal tear production, suggesting that reduced tears are not always the cause of ded sensory dysfunction. in this study, we show that disruption of lacrimal innervation can produce hypoalgesia without changing basal tear production. | 0 | 26513503 |
| psychometric properties of the original and short form of the inventory of callous-unemotional traits in detained female adolescents. | this study examines the psychometric properties of the self-report version of the inventory of callous-unemotional traits in 191 detained female adolescents (m = 15.76, sd = 1.02). evidence supporting the validity of the icu scores was generally weak, largely due to poor functioning of the unemotional subscale. results from confirmatory factor analyses demonstrated support for a recently proposed shortened version of the icu consisting of two subscales (callousness and uncaring). both subscales ... | 0 | 26493393 |
| collagen-induced arthritis: a model for murine autoimmune arthritis. | collagen-induced arthritis (cia) is a common autoimmune animal model used to study rheumatoid arthritis (ra). the development of cia involves infiltration of macrophages and neutrophils into the joint, as well as t and b cell responses to type ii collagen. in murine cia, genetically susceptible mice (dba/1j) are immunized with a type ii bovine collagen emulsion in complete freund's adjuvant (cfa), and receive a boost of type ii bovine collagen in incomplete freund's adjuvant (ifa) 21 days after ... | 0 | 26539560 |
| stable inhibitory activity of regulatory t cells requires the transcription factor helios. | the maintenance of immune homeostasis requires regulatory t cells (t(regs)). given their intrinsic self-reactivity, t(regs) must stably maintain a suppressive phenotype to avoid autoimmunity. we report that impaired expression of the transcription factor (tf) helios by foxp3(+) cd4 and qa-1-restricted cd8 t(regs) results in defective regulatory activity and autoimmunity in mice. helios-deficient t(regs) develop an unstable phenotype during inflammatory responses characterized by reduced foxp3 ex ... | 0 | 26472910 |
| development of a subjective cognitive decline questionnaire using item response theory: a pilot study. | subjective cognitive decline (scd) may indicate unhealthy cognitive changes, but no standardized scd measurement exists. this pilot study aims to identify reliable scd questions. | 0 | 26878034 |
| a behavioral genetic analysis of callous-unemotional traits and big five personality in adolescence. | callous-unemotional (cu) traits, such as lacking empathy and emotional insensitivity, predict the onset, severity, and persistence of antisocial behavior. cu traits are heritable, and genetic influences on cu traits contribute to antisocial behavior. this study examines genetic overlap between cu traits and general domains of personality. we measured cu traits using the inventory of callous-unemotional traits (icu) and big five personality using the big five inventory in a sample of adolescent t ... | 0 | 26595476 |
| the antinociceptive and antiinflammatory properties of 3-furan-2-yl-n-p-tolyl-acrylamide, a positive allosteric modulator of α7 nicotinic acetylcholine receptors in mice. | positive allosteric modulators (pams) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. in this regard, selective α7 nicotinic acetylcholine receptor type ii pams display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. this study investigates whether 3-furan-2-yl-n-p-tolyl-acrylamide (pam-2), a new putative α7-selective type ii pam, attenuates experimental inflammatory and ... | 0 | 26280585 |
| microbiota-dependent sequelae of acute infection compromise tissue-specific immunity. | infections have been proposed as initiating factors for inflammatory disorders; however, identifying associations between defined infectious agents and the initiation of chronic disease has remained elusive. here, we report that a single acute infection can have dramatic and long-term consequences for tissue-specific immunity. following clearance of yersinia pseudotuberculosis, sustained inflammation and associated lymphatic leakage in the mesenteric adipose tissue deviates migratory dendritic c ... | 0 | 26451485 |
| preservation and modification of culture in family socialization: development of parenting measures for korean immigrant families. | this study aims to describe the family socialization beliefs and practices of korean immigrant parents through testing psychometric properties of several newly developed items and scales to assess the major components of the korean traditional concept of family socialization, ga-jung-kyo-yuk. these new measures were examined for validity and reliability. the findings show that korean immigrant parents largely preserve their traditional and core parenting values, while also showing meaningful, ye ... | 0 | 24765236 |
| identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation. | lipids constitute 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (ms). we used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in ms brain, and an animal model of ms to explore the role of the identified lipids in autoimmune demyelination. we found that autoantibodies in ms target a phosphate group in phosphatidylserine and oxidized phosphati ... | 0 | 22674551 |
| factors associated with the implementation of the familias unidas intervention in a type 3 translational trial. | this study highlights how familias unidas, a hispanic-specific, evidence-based, family centered preventive intervention, progressed from intervention development (type 1 translation; t1) through rigorous evaluation (t2) and examines the role of intervention fidelity-adherence and competence-in a t3 trial. effects of participant, provider, and organizational variables on direct (observational) and indirect (self-reported) fidelity were examined as were effects of fidelity. two structural equation ... | 0 | 27012258 |
| the hepatitis b virus core variants that expose foreign c-terminal insertions on the outer surface of virus-like particles. | the major immunodominant region (mir) and n-terminus of the hepatitis b virus (hbv) core (hbc) protein were used to expose foreign insertions on the outer surface of hbc virus-like particles (vlps). the additions to the hbc positively charged arginine-rich c-terminal (ct) domain are usually not exposed on the vlp surface. here, we constructed a set of recombinant hbcg vectors in which ct arginine stretches were substituted by glycine residues. in contrast to natural hbc vlps and recombinant hbc ... | 0 | 26446016 |
| a self-consistent phase-field approach to implicit solvation of charged molecules with poisson-boltzmann electrostatics. | dielectric boundary based implicit-solvent models provide efficient descriptions of coarse-grained effects, particularly the electrostatic effect, of aqueous solvent. recent years have seen the initial success of a new such model, variational implicit-solvent model (vism) [dzubiella, swanson, and mccammon phys. rev. lett. 96, 087802 (2006) and j. chem. phys. 124, 084905 (2006)], in capturing multiple dry and wet hydration states, describing the subtle electrostatic effect in hydrophobic interact ... | 0 | 26723595 |
| systemic immunity influences hearing preservation in cochlear implantation. | to determine whether a systemic immune response influences hearing thresholds and tissue response after cochlear implantation of hearing guinea pigs. | 0 | 22470051 |
| outcomes of percutaneous femoral cannulation for venoarterial extracorporeal membrane oxygenation support. | we report and examine the outcomes of emergency venoarterial extracorporeal membrane oxygenation (ecmo) support initiated via percutaneous cannulation of the femoral vessels. | 0 | 24062897 |
| religious involvement measurement model in a national sample of african americans. | this study examined the factor structure of a brief measure of religious involvement developed previously in research with african american women. telephone interview methods were used with a national sample of both african american women and men (n = 2,370). confirmatory factor analyses supported the distinction between religious beliefs and religious behaviors factors and indicated that the factor loadings were equivalent for women and men. women reported higher levels of religious involvement ... | 0 | 21416161 |
| effects of parity on blood pressure among west african dogon women. | this study examined the effect of parity on blood pressure (bp) readings and bmi among rural west african dogon women. | 0 | 22870582 |
| medical student self-efficacy with family-centered care during bedside rounds. | factors that support self-efficacy in family-centered care (fcc) must be understood in order to foster fcc in trainees. using social cognitive theory, the authors examined (1) how three supportive experiences (observing role models, practicing for mastery, and receiving feedback) influence self-efficacy with fcc during rounds and (2) whether the influence of these supportive experiences was mediated by self-efficacy with three key fcc tasks (relationship building, information exchange, and decis ... | 0 | 22534602 |