Publications

a shortened version of the clinical research appraisal inventory: crai-12.	the original clinical research appraisal inventory (crai), which assesses the self-confidence of trainees in performing different aspects of clinical research, comprises 92 items. completing the lengthy crai is time-consuming and represents a considerable burden to respondents, yet the crai provides useful data for evaluating research training programs. the purpose of this study is to develop a shortened version of the crai and to test its validity and reliability.	23886999
discriminant and convergent validity of the anxiety construct in children with autism spectrum disorders.	despite reports of high anxiety in children with autism spectrum disorders (asd), there is controversy regarding differential diagnosis of asd symptoms and anxiety symptoms. this study examined 88 children, aged 7-11 years, with asd referred for concerns about anxiety. a multitrait-(social anxiety, separation anxiety, overall anxiety severity, and overall asd severity), multimethod-(diagnostic interviews, parent-, and child-based measures) analysis was conducted. results from structural equation ...	23354538
maternal hiv serostatus, mother-daughter sexual risk communication and adolescent hiv risk beliefs and intentions.	daughters of hiv-positive women are often exposed to the same factors that placed their mothers at risk. this cross-sectional study (n = 176 dyads) examined hiv status, parent-teen sexual risk communication (ptsrc), and daughters' abstinence and condom use beliefs and intentions. maternal hiv status was not associated with ptsrc. path analyses show that maternal depression was associated with ptsrc behavioral and normative beliefs; relationship satisfaction was associated with ptsrc normative an ...	22677973
evidence for three subtypes of repetitive behavior in autism that differ in familiality and association with other symptoms.	restricted repetitive behaviors (rrbs) are a core feature of autism and consist of a variety of behaviors, ranging from motor stereotypies to complex circumscribed interests. the objective of the current study was to examine the structure of rrbs in autism using relevant items from the autism diagnostic interview-revised in a sample of 316 individuals with autistic disorder.	19017031
childhood maltreatment and the development of relational and physical aggression: the importance of a gender-informed approach.	this investigation examined the associations between maltreatment and aggression using a gender-informed approach. peer ratings, peer nominations, and counselor reports of aggression were collected on 211 maltreated and 199 nonmaltreated inner-city youth (m age = 9.9 years) during a summer day camp. maltreatment was associated with aggressive conduct; however, these effects were qualified by gender, maltreatment subtype, and the form of aggression under investigation. findings revealed that malt ...	19037946
identifying two potential mechanisms for changes in alcohol use among college-attending and non-college-attending emerging adults.	this study tested whether pro-alcohol peer influences and prosocial involvement account for increases in drinking during the transition into emerging adulthood and whether these mechanisms differ depending on college attendance and/or moving away from home. the authors used structural equation modeling of prospective data from 825 young men and women. for 4 groups defined by college and residential status, more drinking in the spring of 12th grade predicted more pro-alcohol peer influences the f ...	18999326
racial/ethnic differences in breast cancer outcomes among older patients: effects of physician communication and patient empowerment.	to examine racial/ethnic disparities in older women's health-related quality of life (qol) and type of breast cancer treatment as mediated by physician-level and individual-level variables.	19025268
effects of mutual health organizations on use of priority health-care services in urban and rural mali: a case-control study.	to examine the effects of a community-based mutual health organization (mho) on utilization of priority health services, financial protection of its members and inclusion of the poor and other target groups.	19030688
differential genetic and environmental influences on reactive and proactive aggression in children.	while significant heritability for childhood aggression has been claimed, it is not known whether there are differential genetic and environmental contributions to proactive and reactive forms of aggression in children. this study quantifies genetic and environmental contributions to these two forms of aggression in an ethnically diverse urban sample of 9-10 year old twins (n = 1219), and compares results across different informants (child self-report, mother, and teacher ratings) using the reac ...	18615267
testing an idealized dynamic cascade model of the development of serious violence in adolescence.	a dynamic cascade model of development of serious adolescent violence was proposed and tested through prospective inquiry with 754 children (50% male; 43% african american) from 27 schools at 4 geographic sites followed annually from kindergarten through grade 11 (ages 5-18). self, parent, teacher, peer, observer, and administrative reports provided data. partial least squares analyses revealed a cascade of prediction and mediation: an early social context of disadvantage predicts harsh-inconsis ...	19037957
immune system and inflammation.		21593968
measuring latinos' perceptions of depression: a confirmatory factor analysis of the illness perception questionnaire.	this study examined the psychometric properties of the revised illness perception questionnaire adapted for a clinical sample of low-income latinos suffering from depression. participants (n = 339) were recruited from public primary care centers. their average age was 49.73 years and the majority was foreign born females of either mexican or central american descent. confirmatory factor analysis was used to test the factor structure of this measure. construct and discriminant validity and intern ...	18954174
psychometric characteristics of a measure of emotional dispositions developed to test a developmental propensity model of conduct disorder.	lahey and waldman proposed a developmental propensity model in which three dimensions of children's emotional dispositions are hypothesized to transact with the environment to influence risk for conduct disorder, heterogeneity in conduct disorder, and comorbidity with other disorders. to prepare for future tests of this model, a new measure of these dispositions was tested. exploratory factor analysis of potential items was conducted in a sample of 1,358 participants 4 to 17 years of age. confir ...	18991130
correlates of early alcohol and drug use in hispanic adolescents: examining the role of adhd with comorbid conduct disorder, family, school, and peers.	this study examined correlates of early adolescent alcohol and drug use in a community sample of 217 eighth-grade adolescents with behavior problems and from hispanic/latino immigrant families. structural equation modeling was used to examine relationships of multiple contexts (e.g., family, school, and peers) to alcohol and drug use. results suggest that conduct disorder in youth with high levels of hyperactivity symptoms, poor school functioning, and peer alcohol and drug use was directly rela ...	18991132
incorporating measurement non-equivalence in a cross-study latent growth curve analysis.	a large literature emphasizes the importance of testing for measurement equivalence in scales that may be used as observed variables in structural equation modeling applications. when the same construct is measured across more than one developmental period, as in a longitudinal study, it can be especially critical to establish measurement equivalence, or invariance, across the developmental periods. similarly, when data from more than one study are combined into a single analysis, it is again im ...	19890440
neuron-glia crosstalk gets serious: role in pain hypersensitivity.	recent studies show that peripheral injury activates both neuronal and nonneuronal or glial components of the peripheral and central cellular circuitry. the subsequent neuron-glia interactions contribute to pain hypersensitivity. this review will briefly discuss novel findings that have shed light on the cellular mechanisms of neuron-glia interactions in persistent pain.	18784481
delayed release pancrelipase for the treatment of pancreatic exocrine insufficiency associated with cystic fibrosis.	pancreatic enzyme replacement therapy (pert) is the only treatment for malabsorption in cystic fibrosis (cf) caused by pancreatic insufficiency (pi). pi occurs in approximately 85% of patients with cf. pert overcomes some, but not all the signs and symptoms of malabsorption. clinical parameters such as growth, abdominal pain, diarrhea and gassiness, commonly used to adjust pert dosing, are shown not to be good indicators of their effectiveness. the fda does not provide oversight of preparations ...	19209287
development and psychometric evaluation of an arab version of the family peer relationship questionnaire.	little is known about parent and peer relationships in immigrant adolescents due to a dearth of culturally sensitive measures. we adapted the family peer relationship questionnaire (fprq) for arab immigrant mothers and their adolescents. mothers and adolescents completed parallel versions of the arab fprq and measures of child behavior problems, child social relations, and maternal depression. data analyses included confirmatory factor analysis and concurrent validity. the proposed four-factor s ...	18389498
correlative feature analysis on ffdm.	identifying the corresponding images of a lesion in different views is an essential step in improving the diagnostic ability of both radiologists and computer-aided diagnosis (cad) systems. because of the nonrigidity of the breasts and the 2d projective property of mammograms, this task is not trivial. in this pilot study, we present a computerized framework that differentiates between corresponding images of the same lesion in different views and noncorresponding images, i.e., images of differe ...	19175108
postnatal roles of glial cell line-derived neurotrophic factor family members in nociceptors plasticity.	the neurotrophin and glial cell line-derived neurotrophic factor (gdnf) family of growth factors have been extensively studied because of their proven ability to regulate development of the peripheral nervous system. the neurotrophin family, which includes nerve growth factor (ngf), nt-3, nt4/5 and bdnf, is also known for its ability to regulate the function of adult sensory neurons. until recently, little was known concerning the role of the gndf-family (that includes gdnf, artemin, neurturin a ...	18958362
hsv gene transfer in the treatment of chronic pain.	it has proven difficult to use systemic administration of small molecules to selectively modulate nociception. over the past decade, we and others have developed non-replicating herpes simplex virus (hsv)-based vectors to treat chronic pain. subcutaneous inoculation of an hsv vector effectively transduces sensory neurons in the dorsal root ganglion; release of transgene-coded inhibitory neurotransmitters or anti-inflammatory peptides reduces pain-related behaviors in rodent models of chronic inf ...	18958369
reliability and validity of the childhood cancer survivor study neurocognitive questionnaire.	up to 40% of childhood cancer survivors may experience neurocognitive impairment in 1 or more specific domains. as such, regular monitoring has been recommended for patients exposed to cranial irradiation and/or antimetabolite chemotherapy. this study reports the results of a questionnaire developed to identify those survivors who may be experiencing neurocognitive problems.	18792068
cutting edge: th1 cells facilitate the entry of th17 cells to the central nervous system during experimental autoimmune encephalomyelitis.	it has recently been proposed that experimental autoimmune encephalomyelitis, once considered the classical th1 disease, is predominantly th17 driven. in this study we show that myelin-reactive th1 preparations devoid of contaminating il-17(+) cells are highly pathogenic. in contrast, th17 preparations lacking ifn-gamma(+) cells do not cause disease. our key observation is that only th1 cells can access the noninflamed cns. once th1 cells establish the experimental autoimmune encephalomyelitis l ...	18768826
fibroblast-type reticular stromal cells regulate the lymph node vasculature.	the lymph node vasculature is essential to immune function, but mechanisms regulating lymph node vascular maintenance and growth are not well understood. vascular endothelial growth factor (vegf) is an important mediator of lymph node endothelial cell proliferation in stimulated lymph nodes. it is expressed basally in lymph nodes and up-regulated upon lymph node stimulation, but the identity of vegf-expressing cells in lymph nodes is not known. we show that, at homeostasis, fibroblast-type retic ...	18768843
dendritic cells control fibroblastic reticular network tension and lymph node expansion.	after immunogenic challenge, infiltrating and dividing lymphocytes markedly increase lymph node cellularity, leading to organ expansion. here we report that the physical elasticity of lymph nodes is maintained in part by podoplanin (pdpn) signalling in stromal fibroblastic reticular cells (frcs) and its modulation by clec-2 expressed on dendritic cells. we show in mouse cells that pdpn induces actomyosin contractility in frcs via activation of rhoa/c and downstream rho-associated protein kinase ...	25341788
the oncoprotein and transcriptional regulator bcl-3 governs plasticity and pathogenicity of autoimmune t cells.	bcl-3 is an atypical member of the iκb family that modulates transcription in the nucleus via association with p50 (nf-κb1) or p52 (nf-κb2) homodimers. despite evidence attesting to the overall physiologic importance of bcl-3, little is known about its cell-specific functions or mechanisms. here we demonstrate a t-cell-intrinsic function of bcl-3 in autoimmunity. bcl-3-deficient t cells failed to induce disease in t cell transfer-induced colitis and experimental autoimmune encephalomyelitis. the ...	25367572
applying the common sense model to measure representations of arsenic contaminated well water.	theory-based research is needed to understand how people respond to environmental health risk information. both the common sense model (csm) of self-regulation and the mental models approach propose that information shapes individuals' personal understandings that, in turn, influence their decisions and actions. we compare these frameworks and explain how the csm was applied to describe and measure mental representations of arsenic contaminated well water. educational information, key informant ...	18726811
trajectories of social withdrawal from grades 1 to 6: prediction from early parenting, attachment, and temperament.	from 1,092 children in the nichd study of early child care and youth development, the authors identified 3 trajectory patterns of social withdrawal from teacher reports in grades 1-6: a normative consistently low group (86%), a decreasing group (5%) with initially high withdrawal that decreased, and an increasing group (9%) with initially low withdrawal that increased. prediction models supported the role of early dysregulated temperament, insensitive parenting, and attachment. preschool shy tem ...	18793064
the status and future of acupuncture mechanism research.	on november 8-9, 2007, the society for acupuncture research (sar) hosted an international conference to mark the tenth anniversary of the landmark nih [national institutes of health] consensus development conference on acupuncture. more than 300 acupuncture researchers, practitioners, students, funding agency personnel, and health policy analysts from 20 countries attended the sar meeting held at the university of maryland school of medicine, baltimore, md. this paper summarizes important invite ...	18803495
association between socioeconomic status and metabolic syndrome in women: testing the reserve capacity model.	low socioeconomic status (ses) environments may impede the development of a bank of resources, labeled reserve capacity, and may also be stressful, thereby depleting available reserves. in consequence, lower ses persons may experience more negative emotions, leading to adverse health consequences. the authors tested the reserve capacity model in relation to the metabolic syndrome.	18823184
a psychometric evaluation of the revised temperament and character inventory (tci-r) and the tci-140.	the psychometric properties of the newest version of the temperament and character inventory (the tci-r) were evaluated in a large (n = 727) community sample, as was the tci-140, a short inventory derivative. facets-to-scale confirmatory and exploratory factor analyses of the tci-r did not support the organization of temperament and character facet scales within their superordinate domains. five of the 29 facet scales also displayed relatively low internal consistency (a < .70). factor analyses ...	18778164
effects of psychosocial and situational variables on substance abuse among homeless adults.	finding direct and indirect influences of salient psychosocial and situational variables on problem substance use among homeless people is important in designing evidence-based, effective, and relevant interventions for this special population. a stress-coping paradigm in conjunction with situational items specialized for homeless people was used to explore predictive relationships in a sample of homeless adults (n = 664) among (a) psychosocial variables of self-esteem, social support, positive ...	18778134
convergent and discriminant validity of three measures of stage of change.	the university of rhode island change assessment (e. a. mcconnaughy, j. o. prochaska, & w. f. velicer, 1983), the stages of change readiness and treatment eagerness scale (w. r. miller & j. s. tonigan, 1996), and the readiness to change questionnaire (s. rollnick, n. heather, r. gold, & w. hall, 1992) are commonly used multidimensional measures of stage of change. the authors examined the convergent and discriminant validity of drug-use versions of these 3 measures through multitrait-multimethod ...	18778129
methyl jasmonate decreases membrane fluidity and induces apoptosis through tumor necrosis factor receptor 1 in breast cancer cells.	in recent years, studies with plant compounds have shown both chemotherapeutic and chemopreventive properties. this study with plant stress hormones (jasmonates) showed growth inhibitory effects in breast cancer cells. cis-jasmone and methyl jasmonate (mj) inhibited the long-term proliferation of mda-mb-435 and mcf-7 cells. cell cycle analysis showed g0/g1 and s-phase arrest with increasing apoptotic population. cellular signaling studies with mj showed decreased membrane fluidity and activation ...	18690087
assessing regulatory emotional self-efficacy in three countries.	the regulatory emotional self-efficacy (rese) scale was developed to assess perceived self-efficacy in managing negative (neg) and in expressing positive (pos) affect (g. v. caprara & m. gerbino, 2001). in this study of young adults, the factorial structure of the rese scale was found to be similar in italy, the united states, and bolivia. in addition to a factor for pos, neg was represented by a second-order factor of 2 different negative affects: despondency-distress (des) and anger-irritation ...	18778159
construct validity and invariance of four factors associated with colorectal cancer screening across gender, race, and prior screening.	understanding individuals' perceptions of colorectal cancer screening (crcs) is important for developing effective interventions to increase adherence to screening guidelines. theory-based cognitive and psychosocial constructs have been associated with crcs in the literature, but few studies have evaluated the psychometric properties of such measures. we hypothesized a correlated four-factor model, including crcs perceived pros, cons, social influence, and self-efficacy. we also examined measure ...	18768488
the four-factor model of depressive symptoms in dementia caregivers: a structural equation model of ethnic differences.	previous studies have suggested that 4 latent constructs (depressed affect, well-being, interpersonal problems, somatic symptoms) underlie the item responses on the center for epidemiological studies depression (ces-d) scale. this instrument has been widely used in dementia caregiving research, but the fit of this multifactor model and the explanatory contributions of multifactor models have not been sufficiently examined for caregiving samples. the authors subjected ces-d data (n = 1,183) from ...	18808246
factors mediating the association between drinking in the first year after alcohol treatment and drinking at three years.	previous research has shown a significant relationship between alcohol consumption in the first year following alcohol treatment admission and longer term functioning. this finding is clinically important and pertains to the clinical course of alcohol-use disorders(auds). this study investigated mediators of these relationships, focusing on the first year after treatment admission and alcohol consumption 3 years later.	18781248
conceptualization and assessment of disengagement in romantic relationships.	research examining relationship distress and dissolution highlights the importance of romantic disengagement. however, prior conceptualizations and measures of romantic disengagement have tended to combine disengagement with related but distinct constructs hindering the study of romantic disengagement. in the present study we conducted exploratory factor analyses to demonstrate that disengagement is a relatively distinct construct and to clarify the conceptualization of romantic disengagement. m ...	19727315
culture, cross-role consistency, and adjustment: testing trait and cultural psychology perspectives.	trait and cultural psychology perspectives on cross-role consistency and its relation to adjustment were examined in 2 individualistic cultures, the united states (n=231) and australia (n=195), and 4 collectivistic cultures, mexico (n=199), the philippines (n=195), malaysia (n=217), and japan (n=180). cross-role consistency in trait ratings was evident in all cultures, supporting trait perspectives. cultural comparisons of mean consistency provided support for cultural psychology perspectives as ...	18729706
critical evaluation of regulatory t cells in autoimmunity: are the most potent regulatory specificities being ignored?	the identification of cd4+ cd25+ foxp3+ regulatory t (treg) cells as natural regulators of immunity in the periphery and tissues has stimulated tremendous interest in developing therapeutic strategies for autoimmune diseases. in this review, the site of origin, antigen specificity, homing markers and cytokine profiles of treg cells were evaluated in autoimmune colitis and type 1 diabetes, two examples in which treg cells were effective as therapy. these studies were compared with studies of treg ...	18798915
antioxidative and antimutagenic activities of 70% ethanolic extracts from four fungal mycelia-fermented specialty rices.	the health-promoting potential of 70% ethanolic extracts of 4 rice varieties fermented with monascus ruber, phellinus linteus, cordyceps sinensis and agaricus blazei was evaluated mainly focusing on their antioxidative and antimutagenic capacities based on the following parameters: phenolic compound and phytic acid content; inhibitory activity on lipid peroxidation; scavenging activity on dpph radical; suppressing ability on mitomycin c-induced mutagenesis in e. coli cells; and protective effect ...	18818745
epidural dexamethasone decreased inflammatory hyperalgesia and spinal cpla₂ expression in a rat formalin test.	the aim of this study was to investigate the effect of epidural dexamethasone on analgesia and cytosolic phospholipase a₂ (cpla₂) expression in the spinal cord in a rat formalin test.	25323902
communication: modeling charge-sign asymmetric solvation free energies with nonlinear boundary conditions.	we show that charge-sign-dependent asymmetric hydration can be modeled accurately using linear poisson theory after replacing the standard electric-displacement boundary condition with a simple nonlinear boundary condition. using a single multiplicative scaling factor to determine atomic radii from molecular dynamics lennard-jones parameters, the new model accurately reproduces md free-energy calculations of hydration asymmetries for: (i) monatomic ions, (ii) titratable amino acids in both their ...	25296776
creating good relationships: responsiveness, relationship quality, and interpersonal goals.	perceived partner responsiveness is a core feature of close, satisfying relationships. but how does responsiveness originate? can people create relationships characterized by high responsiveness and, consequently, higher quality relationships? the authors suggest that goals contribute to cycles of responsiveness between two people, improving relationship quality for both of them. the present studies examine (a) how interpersonal goals initiate responsiveness processes in close relationships, (b) ...	20565187
item response theory analysis of dsm-iv criteria for inhalant-use disorders in adolescents.	inhalants are a serious public health concern and a dangerous form of substance use. an important unresolved issue in the inhalant literature concerns the validity of inhalant-use diagnoses and the diagnostic and statistical manual of mental disorders, fourth edition, distinction between inhalant abuse and inhalant dependence. to address these limitations and provide the foundation for helping build stronger diagnostic and assessment tools related to inhalant problems, this study examined the di ...	20553671
psychometric properties of the parent and teacher versions of the strengths and difficulties questionnaire for 4- to 12-year-olds: a review.	since its development, the strengths and difficulties questionnaire (sdq) has been widely used in both research and practice. the sdq screens for positive and negative psychological attributes. this review aims to provide an overview of the psychometric properties of the sdq for 4- to 12-year-olds. results from 48 studies (n = 131,223) on reliability and validity of the parent and teacher sdq are summarized quantitatively and descriptively. internal consistency, test-retest reliability, and inte ...	20589428
factor structure of the acute stress disorder scale in a sample of hurricane katrina evacuees.	acute stress disorder (asd) is a poorly understood and controversial diagnosis (a. g. harvey & r. a. bryant, 2002). the present study used confirmatory factor analysis (cfa) to test the factor structure of the most widely used self-report measure of asd, the acute stress disorder scale (r. a. bryant, m. l. moulds, & r. m. guthrie, 2000), in a sample of hurricane katrina evacuees relocated to a red cross emergency shelter in austin, texas. results indicated that the proposed 4-factor structure di ...	20528054
development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments.	to develop an archive of self-report questions assessing sleep disturbance and sleep-related impairments (sri), to develop item banks from this archive, and to validate and calibrate the item banks using classic validation techniques and item response theory analyses in a sample of clinical and community participants.	20550019
more than just openness: developing and validating a measure of targeted parent-child communication about alcohol.	research addressing parent-child communication on the topic of alcohol use relies heavily on assessing frequency of discussions and general assessments of openness in parent-child communication, ignoring the complexity of this communication phenomenon. this study adds to the literature by articulating a conceptualization and developing a measurement of parent-child communication-targeted parent-child communication about alcohol-and comparing the efficacy of targeted parent-child communication ab ...	20512711
heparanase upregulates th2 cytokines, ameliorating experimental autoimmune encephalitis.	heparanase is an endo-beta-d-glucuronidase that cleaves heparan sulfate (hs) saccharide chains. the enzyme promotes cell adhesion, migration and invasion and plays a significant role in cancer metastasis, angiogenesis and inflammation. the present study focuses on the involvement of heparanase in autoimmunity, applying the murine experimental autoimmune encephalitis (eae) model, a t-cell dependent disease often used to investigate the pathophysiology of multiple sclerosis (ms). intraperitoneal a ...	20399501
a multitrait-multimethod analysis of the construct validity of child anxiety disorders in a clinical sample.	the present study examines the construct validity of separation anxiety disorder (sad), social phobia (sop), panic disorder (pd), and generalized anxiety disorder (gad) in a clinical sample of children. participants were 174 children, 6 to 17 years old (94 boys) who had undergone a diagnostic evaluation at a university hospital based clinic. parent and child ratings of symptom severity were assessed using the multidimensional anxiety scale for children (masc). diagnostician ratings were obtained ...	20443053
delineating the maladaptive pathways of child maltreatment: a mediated moderation analysis of the roles of self-perception and social support.	the current study investigated concurrent and longitudinal mediated and mediated moderation pathways among maltreatment, self-perception (i.e., loneliness and self-esteem), social support, and internalizing and externalizing behavior problems. for both genders, early childhood maltreatment (i.e., ages 0-6) was related directly to internalizing and externalizing behavior problems at age 6, and later maltreatment (i.e., ages 6-8) was directly related to internalizing and externalizing behavior pro ...	20423545
do neuropsychological tests have the same meaning in spanish speakers as they do in english speakers?	the purpose of this study was to examine whether neuropsychological tests translated into spanish measure the same cognitive constructs as the original english versions.	20438217
health problem behaviors in iranian adolescents: a study of cross-cultural adaptation, reliability, and validity.	the main purpose of this study was to assess the factorial validity and reliability of the iranian versions of the personality and behavior system scales (49 items) of the ahdq (the adolescent health and development questionnaire) and interrelations among them based on jessor's pbt (problem behavior theory).	21526075
psychometrics of a self-report version of the child and adolescent dispositions scale.	lahey and waldman (2003, 2005) proposed a model in which three dispositions-sympathetic response to others; negative emotional response to threat, frustration, and loss; and positive response to novelty and risk-transact with the environment to influence risk for conduct disorder (cd). to test this model, the child and adolescent dispositions scale (cads) was developed to measure these dispositions using parent ratings of the child. here we report psychometric evaluations of a parallel youth sel ...	20419576
calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.	lysophosphatidic acid receptor (lpa(1)) signaling initiates neuropathic pain through demyelination of the dorsal root (dr). although lpa is found to cause down-regulation of myelin proteins underlying demyelination, the detailed mechanism remains to be determined. in the present study, we found that a single intrathecal injection of lpa evoked a dose- and time-dependent down-regulation of myelin-associated glycoprotein (mag) in the dr through lpa(1) receptor. a similar event was also observed in ...	20420580
assessment of a brief ces-d measure for depression in homebound medically ill older adults.	depressive symptoms are highly prevalent among medically ill homebound elderly and are associated with significant functional decline, lower quality of life, and increased health care utilization. despite this, depression is generally underdiagnosed and undertreated among medically ill homebound older adults. the objective of this study was to determine the validity of a brief depression measure (ces-d) and examine the nature of depressive symptoms reported by the older sample. using confirmator ...	20461617
dorsal horn alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking in inflammatory pain.	activation of synaptic n-methyl-d-aspartic acid receptor and its intracellular downstream signals in dorsal horn neurons of spinal cord contribute to central sensitization, a mechanism that underlies the development and maintenance of pain hypersensitivity in persistent pain. however, the molecular process of this event is not understood completely. recently, new studies suggest that peripheral inflammatory insults drive changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid recepto ...	20395828
psychosocial factors influencing calcium intake and bone quality in middle school girls.	calcium intake has been associated with promoting bone health in children and adolescents, thus preventing osteoporosis later in life. behavior change such as increased calcium intake, as well as physiological factors such as bone quality, may be facilitated by psychosocial and environmental factors. the purpose of this study was to identify pathways by which psychosocial factors influence calcium intake and bone quality in middle school girls. the study design was cross-sectional. baseline data ...	20497785
using the information-motivation behavioral model to predict sexual behavior among underserved minority youth.	testing, refining, and tailoring theoretical approaches that are hypothesized to reduce sexual risk behaviors among adolescent subpopulations is an important task. relatively little is known about the relationship between components of the information-motivation-behavior (imb) model and sexual behaviors among underage minority youth. using the imb model, this study examines predictors of risky sexual behavior among underserved hispanic and african-american youth.	20573141
psychometric properties and u.s. national norms of the evidence-based practice attitude scale (ebpas).	the evidence-based practice attitude scale (ebpas) assesses mental health and social service provider attitudes toward adopting evidence-based practices. scores on the ebpas derive from 4 subscales (i.e., appeal, requirements, openness, and divergence) as well as the total scale, and preliminary studies have linked ebpas scores to clinic structure and policies, organizational culture and climate, and first-level leadership. ebpas scores are also related to service provider characteristics, inclu ...	20528063
advanced glycation end products in foods and a practical guide to their reduction in the diet.	modern diets are largely heat-processed and as a result contain high levels of advanced glycation end products (ages). dietary advanced glycation end products (dages) are known to contribute to increased oxidant stress and inflammation, which are linked to the recent epidemics of diabetes and cardiovascular disease. this report significantly expands the available dage database, validates the dage testing methodology, compares cooking procedures and inhibitory agents on new dage formation, and in ...	20497781
mother-grandmother coparenting relationships in families with incarcerated mothers: a pilot investigation.	using new methods designed to assess coparenting between incarcerated mothers of preschool-aged children and the maternal grandmothers caring for the children during their absence, we examined relationships between coparenting quality during the mother's jail stay and both concurrent child behavior problems and later coparenting interactions following mothers' release and community reentry. forty mother-grandmother dyads participated in joint coparenting discussions during the incarceration, wit ...	20594205
testing model nesting and equivalence.	when using existing technology, it can be hard or impossible to determine whether two structural equation models that are being considered may be nested. there is also no routine technology for evaluating whether two very different structural models may be equivalent. a simple nesting and equivalence testing (net) procedure is proposed that uses random sample and model-reproduced moment matrices to evaluate both model nesting and equivalence. the analysis is "local" rather than "global" in natur ...	20515234
aquaporins in sensory and pain transmission.	recent data suggest a possible involvement of aquaporins (aqps) in pain transmission. aqps are small membrane channel proteins involved in osmoregulation and, to date, aqp1, aqp2, aqp3, aqp4, aqp5, aqp8 and aqp9 have been found in the nervous system. nevertheless only aqp1, aqp2 and aqp4 seem to be involved in nociception.in this review, direct and indirect evidences of the role of aqps in pain processing will be reported.	21119883
mir-155 promotes t follicular helper cell accumulation during chronic, low-grade inflammation.	chronic inflammation is a contributing factor to most life-shortening human diseases. however, the molecular and cellular mechanisms that sustain chronic inflammatory responses remain poorly understood, making it difficult to treat this deleterious condition. using a mouse model of age-dependent inflammation that results from a deficiency in mir-146a, we demonstrate that mir-155 contributed to the progressive inflammatory disease that emerged as mir146a(-/-) mice grew older. upon analyzing lymph ...	25367574
hif transcription factors, inflammation, and immunity.	the hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (hif) transcription factors; these play an integral role in the metabolic changes that drive cellular adaptation to low oxygen availability. hif expression and stabilization in immune cells can be triggered by hypoxia, but also by other factors associated with pathological stress: e.g., inflammation, infectious microorganisms, and cancer. hif induces a number of aspects of host immune function, from b ...	25367569
description and psychometric evaluation of the youth counseling impact scale.	the present article describes and evaluates the youth counseling impact scale (ycis; l. bickman et al., 2007), a recently developed therapeutic process measure that assesses youths' perceptions of the impact individual mental health counseling sessions have on their thoughts, feelings, and behaviors. this measure is intended for frequent use in the mental health treatment of youths aged 11-18. it provides a general impact score as well as two subscale scores: insight and change. five hundred you ...	20528053
sleep quality and fatigue among prehospital providers.	fatigue is common among medical professionals and has been linked to poor performance and medical error. objective. to characterize sleep quality and its association with severe fatigue in emergency medical services (ems) providers.	20199233
drug risk: a cross-sectional exploration of the influence of family-of-origin and current situational circumstances.	the main objective of this paper is to investigate potential predictors of drug risk among a community-based sample of individuals who are exposed to illicit drugs. the four domains of interest are individual socio-demographic and social-psychological attributes, current situational circumstances and family-of-origin characteristics. interviews were conducted with 242 individuals who were recruited in atlanta, georgia. initial descriptive analyses were followed by multivariate analyses. the fina ...	24039278
using psychometric techniques to improve the balance evaluation systems test: the mini-bestest.	to improve, with the aid of psychometric analysis, the balance evaluation systems test (bestest), a tool designed to analyse several postural control systems that may contribute to poor functional balance in adults.	20461334
increasing culturally competent neuropsychological services for ethnic minority populations: a call to action.	us demographic and sociopolitical shifts have resulted in a rapidly growing need for culturally competent neuropsychological services. however, clinical neuropsychology as a field has not kept pace with the needs of ethnic minority clients. in this discussion we review: historical precedents and the limits of universalism in neuropsychology; ethical/professional guidelines pertinent to neuropsychological practice with ethnic minority clients; critical cultural considerations in neuropsychology; ...	20373222
longitudinal studies of anger and attention span: context and informant effects.	this study examined stabilities of informant and context (home vs. classroom) latent factors regarding anger and attention. participants included children from the national institute of child health and development study of early child care and youth development who were measured at 54 months, first grade, and third grade. latent factors of anger and attention span were structured using different indicators based on mothers', fathers', caregivers', teachers', and observers' reports. we used stru ...	20433625
perceived barriers to psychological treatments and their relationship to depression.	in spite of repeated calls for research and interventions to overcome individual and systemic barriers to psychological treatments, little is known about the nature of these barriers. to develop a measure of perceived barriers to psychological treatment (pbpt), items derived from 260 participants were administered to 658 primary care patients. exploratory factor analysis on half the sample resulted in 8 factors, which were supported by confirmatory factor analysis conducted on the other half. as ...	20127795
nanomicellar formulations for sustained drug delivery: strategies and underlying principles.	micellar delivery systems smaller than 100 nm can be readily prepared. while micelles allow a great depth of tissue penetration for targeted drug delivery, they usually disintegrate rapidly in the body. thus, sustained drug delivery from micellar nanocarriers is a challenge. this article summarizes various key strategies and underlying principles for sustained drug delivery using micellar nanocarriers. comparisons are made with other competing delivery systems such as polymeric microparticles an ...	20394539
therapist fidelity with an exposure-based treatment of ptsd in adults with schizophrenia or schizoaffective disorder.	this study examined therapists' fidelity to a manualized, multicomponent cognitive-behavioral intervention for posttraumatic stress disorder (ptsd), including exposure therapy, among public sector patients with a psychotic disorder. independent raters assessed therapists' competence and adherence, rating 20% of randomly selected audio taped sessions (n=57 sessions, coded by two raters, with strong interrater agreement). adherence ratings indicated that therapists complied well with the protocol, ...	20112407
long-term effects of the family bereavement program on multiple indicators of grief in parentally bereaved children and adolescents.	this article reports on results from a randomized experimental trial of the effects of the family bereavement program (fbp) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period.	20350025
a prospective investigation of interpersonal influences on the pursuit of muscularity in late adolescent boys and girls.	this project examined whether interpersonal pressure to be muscular predicted late adolescents' pursuit of muscularity. participants were 199 adolescents (16-19 years), mothers (n = 175), and friends (n = 159), assessed at two annual times. pressure to be muscular was assessed with adolescents', mothers', and friends' reports of their relationships. adolescents reported pressure from fathers and romantic partners, appearance satisfaction, disordered eating, and pursuit of muscularity. adolescent ...	20348360
understanding early contextual and parental risk factors for the development of limited prosocial emotions.	a growing body of evidence suggests that parenting influences the development of youth callous unemotional (cu) behavior. however, less is known about the effects of parenting or contextual risk factors on 'limited prosocial emotions' (lpe), a recent conceptualization of cu behavior added to the dsm-5. we focused on lpe at ages 10-12 and age 20 among low income, urban males (n = 310), and examined potential developmental precursors, including contextual risk factors assessed during infancy and o ...	25510355
poor self-control and harsh punishment in childhood prospectively predict borderline personality symptoms in adolescent girls.	developmental theories of borderline personality disorder (bpd) propose that harsh, invalidating parenting of a child with poor self-control and heightened negative emotionality often leads to a coercive cycle of parent-child transactions that increase risk for bpd symptoms such as emotion dysregulation. although parenting practices and child temperament have previously been linked with bpd, less is known about the prospective influences of caregiver and child characteristics. using annual longi ...	25961815
thermosensitive transient receptor potential (trp) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal models.	the present paper summarizes research using animal models to investigate the roles of thermosensitive transient receptor potential (trp) channels in somatosensory functions including touch, temperature and pain. we present new data assessing the effects of eugenol and carvacrol, agonists of the warmth-sensitive trpv3, on thermal, mechanical and pain sensitivity in rats.	26388966
examining general and specific factors in the dimensionality of oral language and reading in 4th-10th grades.	the objective of this study was to explore dimensions of oral language and reading and their influence on reading comprehension in a relatively understudied population-adolescent readers in 4th through 10th grades. the current study employed latent variable modeling of decoding fluency, vocabulary, syntax, and reading comprehension so as to represent these constructs with minimal error and to examine whether residual variance unaccounted for by oral language can be captured by specific factors o ...	26346839
a novel monoclonal antibody against human dab2ip.	dab2 interactive protein (dab2ip), also known as ask1-interacting protein-1 (aip1), a novel member of the rasgtpase-activating protein family, plays a key role in tumor suppression during cancer progression and is highly expressed in vascular smooth muscle cells (vsmcs) and endothelial cells (ecs). to further explore its function as a cancer suppressor, in this study, we immunized balb/c mice with synthesized human dab2ip polypeptide and obtained a novel monoclonal antibody (mab) against human d ...	26301928
21(st) century cures act: an act of cure or diagnosis?		26291241
five-year retrograde transpopliteal angioplasty results compared with antegrade angioplasty.	retrograde transpopliteal angioplasty (pa) is a potentially useful alternative technique for endovascular treatment of infra-inguinal arterial disease when antegrade transfemoral puncture (fa) is technically not possible or appropriate. this study aimed to investigate the outcomes of pa compared with fa during a 5-year period.	20501022
the 11-item medication adherence reasons scale: reliability and factorial validity among patients with hypertension in malaysian primary healthcare settings.	the aim of this study was to assess the reliability and validity of a modified malaysian version of the medication adherence reasons scale (mar-scale).	25902719
the structure of social exchange in self-help support groups: development of a measure.	self-help support groups are indigenous community resources designed to help people manage a variety of personal challenges, from alcohol abuse to xeroderma pigmentosum. the social exchanges that occur during group meetings are central to understanding how people benefit from participation. this paper examines the different types of social exchange behaviors that occur during meetings, using two studies to develop empirically distinct scales that reliably measure theoretically important types of ...	24398622
multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in leishmania infantum.	the structures of phosphatidylethanolamine (pe) in leishmania infantum are unique in that they consist of a rare cyclopropane fatty acid (cfa) containing pe subfamily, including cfa-containing plasmalogen pe species. in this contribution, we applied multiple-stage linear ion-trap combined with high-resolution mass spectrometry to define the structures of pes that were desorbed as [m - h](-) and [m - h + 2li](+) ions by esi, respectively. the structural information arising from ms(n) on both the ...	24619546
constructing and identifying predictors of frailty among homeless adults—a latent variable structural equations model approach.	homeless urbanites are a heterogeneous population with unique health and social service needs. the study examined situational, behavioral, health-related and resource indicators in terms of their direct impact on frailty, hypothesized as a latent variable. using structural equation modeling (sem), a model was tested with 150 homeless men and women, ages 40–73, from three homeless day center drop-in sites on skid row and one residential drug treatment (rdt) facility that works with homeless parol ...	24505611
high frequency oscillations and infraslow activity in epilepsy.	in pre-surgical evaluation of epilepsy, there has been an increased interest in the study of electroencephalogram (eeg) activity outside the 1-70 hz band of conventional frequency activity (cfa). research over the last couple of decades has shown that eeg activity in the 70-600 hz range, termed high frequency oscillations (hfos), can be recorded intracranially from all brain regions both interictally and at seizure onset. in patients with epilepsy, hfos are now considered as pathologic regardles ...	24791097
novel treatment of coronary artery fistulae concealing severe coronary artery lesion: using thrombus aspiration catheter as a delivery guide.	in this case report, we present the occlusion of multiple coronary artery fistulae originating from proximal left anterior descending (lad) and right sinus valsavla and empting to the pulmonary artery at the same place. we occluded lad fistulae by using thrombus aspiration catheter as a delivery guide. to the best of our knowlege, this is the first case of occlusion of coronary fistulae with the help of thrombus aspiration catheter. our experience may suggest that thrombus aspiration catheters c ...	24748888
early adolescent substance use as a risk factor for developing conduct disorder and depression symptoms.	conduct disorder and depression symptoms are well-established risk factors for substance use during adolescence. however, few investigations have examined whether early substance use increases adolescents' risk of developing conduct disorder/depression symptoms.	24650822
relationship-specific alcohol expectancies and gender moderate the effects of relationship drinking contexts on daily relationship functioning.	research shows that drinking with one's partner in romantic relationships is associated with positive relationship functioning (e.g., increased intimacy), whereas drinking apart from one's partner is associated with negative relationship functioning (e.g., increased negative behaviors/events). relationship-specific alcohol expectancies (rsae) may moderate these associations and illuminate for whom these processes are more positive or negative. the current study tested rsae as a moderator of the ...	24650821
a mediational model of racial discrimination and alcohol-related problems among african american college students.	racial discrimination has been identified as an important predictor of alcohol-related outcomes for african americans. the goal of the current study was to extend previously found links between lifetime discrimination, alcohol use, and alcohol problems as well as to elucidate the affective mechanisms underlying these associations, as moderated by gender.	24650816
healthcare task difficulty among older adults with multimorbidity.	applying disease-specific guidelines to people with multimorbidity may result in complex regimens that impose treatment burden.	24561750
planned missing-data designs in experience-sampling research: monte carlo simulations of efficient designs for assessing within-person constructs.	experience-sampling research involves trade-offs between the number of questions asked per signal, the number of signals per day, and the number of days. by combining planned missing-data designs and multilevel latent variable modeling, we show how to reduce the items per signal without reducing the number of items. after illustrating different designs using real data, we present two monte carlo studies that explored the performance of planned missing-data designs across different within-person ...	23709167
the use of protective behaviors in relation to gambling among college students.	the purpose of the current study was to evaluate a measure of gambling protective behaviors and examine the relationship between indices of gambling behavior, including frequency, quantity and problem severity, and the use of gambling protective behaviors. undergraduates from a large public university (n = 4,014) completed a web-based screening survey comprising measures of gambling and health behaviors, from which those who gambled within the past 6-months (n = 1,922, 48 % of the entire sample) ...	23224712
determining factors of observance of antiretroviral treatments in cameroon during the start-up period (2000-2002).	highlight the socioeconomic and environmental determining factors of long-term observance to antiretroviral treatments in developing countries.	25214897
parenting quality: confirmation of a higher-order latent construct with mothers of head start children.	we proposed a higher order latent construct of parenting young children, parenting quality. this higher-order latent construct comprises five component constructs: demographic protection, psychological distress, psychosocial maturity, moral and cognitive reflectivity, and parenting attitudes and beliefs. we evaluated this model with data provided by 199 mothers of 4-year-old children enrolled in head start. the model was confirmed with only one adjustment suggested by modification indices. final ...	19629192