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innervation of the lower eyelid in relation to blepharoplasty and midface lift: clinical observation and cadaveric study.ectropion or scleral show resulting from weakness of the lower eyelids is not uncommon after lower blepharoplasty or midface lift via blepharoplasty incision. denervation of the pretarsal orbicularis oculi muscle (oom) attributes to such complications. the authors analyzed 102 patients who underwent midface lift via lower blepharoplasty incision for the past 3 years and investigated the motor nerve innervation of the lower oom in 20 cadavers. they encountered two cases of ectropion attributed to ...200111756795
monitoring pcbs in polar bears: lessons learned from svalbard.monitoring pollutants in the biota of the arctic is a high priority activity of the circumpolar arctic nations. polar bears (ursus maritimus) are one species that have been selected for monitoring, owing to their high trophic position in the arctic marine ecosystem and high contaminant levels. considerable research has been directed at understanding the effects of pollutants, and ultimately these effects are tied to temporal trends in pollutant levels. this paper reports on the state of contamin ...200111695117
polar bears fuel row over alaskan oil. 200111713490
ecological risk assessment of persistent organic pollutants in the arctic.ecological risk assessment of persistent organic chemicals in marine mammals in the arctic would comprise assessments of both exposure and effect and risk characterization. results from a comprehensive collaborative study between norwegian and canadian researchers, comprising epizoological (ecological) studies (reproductive rate, offspring survival), experimental studies on the immune system function, monitoring studies (e.g. physiological assays of thyroid hormones, retinol, igg and testosteron ...200212505309
seasonal changes in testicular size and serum lh, prolactin and testosterone concentrations in male polar bears (ursus maritimus).little is known about the reproductive endocrinology of the male polar bear, ursus maritimus, except that serum testosterone concentrations are high in april and may during the mating season and are low from august to november during the non-mating season. the objective of this study was to describe the relationship between seasonal changes in testicular size and serum concentrations of testosterone, lh and prolactin. blood samples and testicular measurements were obtained from free-ranging male ...200212006101
body burdens and tissue concentrations of organochlorines in polar bears (ursus maritimus) vary during seasonal fasts.lipophilic organochlorines (ocs) are ingested by mammals through their foods and are generally stored in adipose tissue depots. for some species, such as polar bears, the size of these depots can fluctuate seasonally by several-fold. however, the effect of these fluctuations on the fate of stored ocs in an animal with such labile lipid depots is unknown. we determined the whole body burden and tissue concentrations of ocs in free-ranging polar bears categorized by age (cubs-of-the-year, yearling ...200211996380
polar bear liver, vitamin a, aquaporins, and pseudotumor cerebri. 200212402248
specificity of measures of thought control.the rebound effect (d. m. wegner, 1994) essentially involves the persistence of thought when an effort has been made to suppress the cognitive activity. some of the research in this area has been directed at determining personal factors that predict differential levels of rebound. to this end, measures of thought control have emerged. in the present study the authors examined the properties of 2 measures of thought control: the thought control questionnaire (tcq; a. wells & m. i. davies, 1994) a ...200212081090
contrasting the ironic monitoring and motivational explanations of postsuppressional rebound.suppressing a thought often results in postsuppressional rebound, that is, a subsequent increase in the incidence of the suppressed thought. the present study was dcsigned to distinguish between two explanations of rebound: wegner's 1994 ironic monitoring theory and liberman and forster's 2000 motivational account. participants (99 deakin university students) first suppressed, then expressed, thoughts of a white bear. in some conditions, a delay--presented as occurring either intentionally or un ...200212061583
genetic diversity and differentiation of kermode bear populations.the kermode bear is a white phase of the north american black bear that occurs in low to moderate frequency on british columbia's mid-coast. to investigate the genetic uniqueness of populations containing the white phase, and to ascertain levels of gene flow among populations, we surveyed 10 highly polymorphic microsatellite loci, assayed from trapped bear hairs. a total of 216 unique bear genotypes, 18 of which were white, was sampled among 12 localities. island populations, where kermodes are ...200211972757
persistent organochlorine pollutants in ringed seals and polar bears collected from northern alaska.blubber samples from ringed seal (phoca hispida; n = 8) and polar bear subcutaneous fat (ursus maritimus; n = 5) were collected near barrow, alaska in 1996 as part of the alaska marine mammal tissue archival project (ammtap) and retained in the national biomonitoring specimen bank at the national institute of standards and technology in gaithersburg, maryland (usa). the samples were analyzed for a variety of persistent organochlorine pollutants (pops) including polychlorinated biphenyls (pcbs), ...200211885579
plasma biochemical values from apparently healthy free-ranging polar bears from svalbard.to establish reference values for free-ranging polar bears (ursus maritimus) at svalbard, norway, plasma samples from 15 females and 20 males were analyzed for 28 blood biochemistry parameters. animals were chemically immobilized (zoletil: tiletamine and zolazepam) on land at barentsøya, edgeøya, and the eastern coast of spitsbergen in august 1998. all bears were apparently healthy, with ages ranging from 1-22 yr. females had almost two times higher levels of lipase than males. several parameter ...200212238374
emerging morbillivirus infections of marine mammals: development of two diagnostic approaches.in the last 13 years, four viruses belonging in the morbillivirus genus of the paramyxoviridae family have emerged as significant causes of disease and mortality in marine mammals. the viruses involved are canine distemper virus (cdv) in seals and polar bears, dolphin morbillivirus (dmv) and porpoise morbillivirus (pmv) in cetaceans, and phocine distemper virus (pdv) in pinnipeds. the two cetacean morbilliviruses (dmv and pmv) are now considered to be the same viral species, named cetacean morbi ...200212381563
cerebral arteriosclerosis in an aged captive polar bear (ursus maritimus).cerebral arteriosclerosis was observed upon necropsy of a 36-yr-old female captive polar bear (ursus maritimus) that developed a sudden onset of seizure-like activity and died. the medium and large cerebral arteries of the meninges had moderate to severe diffuse discoloration and mineralization of the matrix of the tunica media, with little or no associated cellular reaction. scanning electron microscopy of the affected arteries showed discrete crystalline calcified deposits in the media and scl ...200212564538
polar bear hemoglobin and human hb a0: same 2,3-diphosphoglycerate binding site but asymmetry of the binding?polar bear (ursus maritimus) hemoglobin (hb) shows a low response to 2,3-diphosphoglycerate (2,3-dpg), compared to human hb a0, even though these proteins have the same 2,3-dpg-binding site. in addition, polar bear hb shows a high response to chloride and an alkaline bohr effect (deltalog p50/deltaph) that is significantly greater than that of human hb a0. the difference in sequence pro (hb a0)-->gly (polar bear hb) at position a2 in the a helix seems to be critical for reduced binding of 2,3-dp ...200212484631
comparison of seven blastomyces dermatitidis antigens for the detection of antibodies in humans with occupationally acquired blastomycosis.yeast phase lysate antigens, prepared from seven isolates of blastomyces dermatitidis (dogs, t-58, m-98; human, le; soil, s; sea lion, sl; polar bear, pb; cat, c) were assayed by enzyme-linked immunosorbent assay (elisa) to detect antibodies in human sera. the sera were from individuals potentially exposed to b. dermatitidis while working on a prairie dog relocation project in colorado. all antigens exhibited greatest reactivity with three specimens in two separate assays. absorbance values rang ...200212572716
polychloronaphthalenes and other dioxin-like compounds in arctic and antarctic marine food webs.here we report accumulation patterns of polychlorinated naphthalenes (pcns), polychlorinated dibenzo-p-dioxins (pcdds), polychlorinated dibenzofurans (pcdfs), polychlorinated biphenyls (pcbs), and pesticides (hcb, p,p'dde) in polar organisms (polar bear from alaskan arctic and krill, sharp-spined notothen, crocodile icefish, antarctic silverfish, adélie penguin, south polar skua, and weddell seal from the ross sea, antarctica). pcns, found in most of the samples, ranged from 1.5 pg/g in krill to ...200212214639
polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls in polar bear, penguin and south polar skua.concentrations of 2378-substituted polychlorinated dibenzo-p-dioxins (pcdds), dibenzofurans (dfs) and non- and mono-ortho-substituted polychlorinated biphenyls (dioxin-like pcbs) were measured in livers of polar bears from the alaskan arctic and in eggs of adelie penguin and south polar skua and weddell seal liver, fish and krill from antarctica. this is one of the first reports to document the concentrations of pcdds/dfs in polar bear livers from alaska, and in penguin and skua eggs from antarc ...200212152823
contaminants in svalbard polar bear samples archived since 1967 and possible population level effects.blood plasma samples were collected in 1967 from 32 polar bears (ursus maritimus) in eastern svalbard. these samples were stored frozen until 2001 and then analyzed for 33 polychlorinated biphenyls (pcb), two toxaphene congeners, ddts, chlordanes (chl), hexachlorobenzene, hexachlorocyclohexanes (hchs), and polybrominated flame retardants (biphenyls and diphenyl ethers). the 1967 pollutant levels were compared with values from 1993 to 1994 for adult females and adult males to obtain insights into ...200312493194
distribution of vitamin a-storing lipid droplets in hepatic stellate cells in liver lobules--a comparative study.to investigate the storage mechanisms of vitamin a, we examined the liver of adult polar bears and arctic foxes, which physiologically store a large amount of vitamin a, by high-performance liquid chromatography (hplc), transmission electron microscopy (tem) morphometry, gold chloride staining, fluorescence microscopy for the detection of autofluorescence of vitamin a, staining with hematoxylin-eosin (h&e), masson's trichrome, and ishii and ishii's silver impregnation. hplc revealed that the pol ...200312552640
glycero- versus sphingo-phospholipids: correlations with human and non-human mammalian lens growth.the human lens differs from other mammalian lenses in its very slow growth and unusual phospholipid composition of its cell membranes. dihydrosphingomyelins (dhsms) make up about half of all phospholipids in adult human fiber membranes. in all other membranes, sphingomyelins(sms) with a trans double bond in their backbone, are prevalent. in our quest to understand the biological implications of such elevated dhsm levels, we analyzed membranes from various regions of human, elephant, giraffe, pol ...200312742355
differences in oligosaccharide pattern of a sample of polar bear colostrum and mid-lactation milk.although the concentrations of carbohydrate in the colostrum and in the mid-lactation milk of polar bear (ursus maritimus) were similar, the oligosaccharide patterns differed. the colostrum sample contained neu5ac(alpha2-3)gal(beta1-4)glc (3'-n-acetylneuraminyllactose), galnac(alpha1-3)[fuc(alpha1-2)]gal(beta1-4)glc (a-tetrasaccharide), fuc(alpha1-2)gal(beta1-4)glc (2'-fucosyllactose) and gal(beta1-4)glc (lactose). the mid-lactation milk contained gal(alpha1-3)[fuc(alpha1-2)]gal(beta1-4)[fuc(alp ...200314662310
blastomyces dermatitidis lysate antigens: antibody detection in serial serum specimens from dogs with blastomycosis.yeast phase lysate antigens prepared from different isolates of blastomyces dermatitidis (t-58, dog-tennessee; t-27, polar bear-tennessee; erc-2, dog-wisconsin; er-3, woodpile-wisconsin) were compared with respect to the detection of antibodies (indirect enzyme-linked immunosorbent assay-elisa, peroxidase system) in 126 serial serum specimens (pre-treatment, 30 and 60 days post-treatment with itraconazole) from 42 dogs with diagnosed blastomycosis. mean absorbance values observed with the four l ...200314682453
geographical distribution of organochlorine pesticides (ocps) in polar bears (ursus maritimus) in the norwegian and russian arctic.geographical variation of organochlorine pesticides (ocps) was studied in blood samples from 90 adult female polar bear (ursus maritimus) from svalbard, franz josef land, kara sea, east-siberian sea and chukchi sea. in all regions, oxychlordane was the dominant ocp. regional differences in mean levels of hcb, oxychlordane, trans-nonachlor, alpha-hch, beta-hch and p,p'-dde were found. the highest levels of oxychlordane, trans-nonachlor and dde were found in polar bears from franz josef land and k ...200312699924
distribution of methyl sulfone metabolites of polychlorinated biphenyls and p,p'-dde in human tissues.we determined methylsulfonyl metabolites of chlorinated biphenyls (meso2-cbs) and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (p,p'-dde) in human adipose, liver, brain, and lung tissues obtained from 11 belgian individuals (9-62 years of age). the total concentration of meso2-cbs (lipid weight basis) decreased in the following order: liver (mean, 9.30 ng/g; range, 1.68-27.03 ng/g lipid) > lung [mean, 2.72 ng/g; range, not detected (nd) to 11.54 ng/g lipid] > adipose tissue (mean, 1.57 ng/g; range ...200312842777
profile of persistent chlorinated contaminants, including selected chiral compounds, in wolverine (gulo gulo) livers from the canadian arctic.wolverines (gulo gulo) are circumpolar omnivores that live throughout the alpine and arctic tundra ecosystem. wolverine livers were collected at kugluktuk (coppermine), nu (n=12) in the western canadian arctic to report, for the first time, the residue patterns of persistent organochlorine contaminants (ocs) in this species. the enantiomer fractions (efs) of several chiral ocs, including pcb atropisomers, in wolverines were also determined. results were compared to oc concentrations and efs of c ...200312948539
organochlorines affect the major androgenic hormone, testosterone, in male polar bears (ursus maritimus) at svalbard.normal sexual development and subsequent reproductive function are dependent on appropriate testosterone production and action. the regulation of steroid hormones, including androgens, can be influenced by both biological and environmental factors, including environmental chemicals. concentrations of organochlorines are considerably greater in svalbard polar bears than in polar bears from other regions. between 1995 and 1998, samples were collected from 121 male polar bears (ursus maritimus) fro ...200314710596
how to suppress obsessive thoughts.thought suppression (i.e. consciously trying to avoid certain thoughts from entering consciousness) has been argued to be an inadequate strategy in case of unwanted intrusions. that is, thought suppression seems to result in more rather than less intrusions. although this experimental finding has been explained in terms of failing attempts to distract oneself from the target thought, the white bear suppression inventory (wbsi; a scale that measures chronic thought suppression tendencies) does no ...200312488122
space-use strategy is an important determinant of pcb concentrations in female polar bears in the barents sea.space-use was examined in 54 female polar bears (ursus maritimus) from svalbard and the barents sea that were collared with satellite transmitters to provide information on their spatial positions and annual home range sizes. plasma samples from the same animals were analyzed for concentrations of six relevant pcb congeners (pcb-99, -153, -156, -180, -194, and -118). factors related to space-use strategy (such as home range size; annual, spring, and winter longitudinal position; and spring and s ...200314620819
roaming polar bears reveal arctic role of pollutants. 200314603277
anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine.immobilization features and physiologic effects of combinations of xylazine-zolazepam-tiletamine (xzt) and zolazepam-tiletamine (zt or telazol) were compared in nine captive and 17 free-ranging polar bears (ursus maritimus) between 1998 and 2001. although induction time was similar between drugs, induction dosage and volume were less with xzt. induction of immobilization with xzt was predictable and smooth, muscle relaxation was good, and all bears remained completely immobilized and unresponsiv ...200314567228
the effects of a documentary film about schizophrenia on psychiatric stigma.this study examined whether viewing a documentary that depicts individuals with schizophrenia can reduce psychiatric stigma. one hundred and sixty-three individuals were randomly assigned to one of four conditions: no documentary film, documentary about polar bears, documentary about fears of being overweight, and documentary about schizophrenia. participants also completed a battery of tasks assessing attitudes toward persons with schizophrenia, attributions about the disorder, and intentions t ...200314552511
right atrial migration and percutaneous retrieval of a günther tulip inferior vena cava filter.this report describes a 67-year-old trauma victim in whom a retrievable günther tulip (cook, bloomington, in) inferior vena cava filter was placed. the filter migrated to the right atrium immediately after placement. initial attempts to retrieve the filter with amplatz goose neck snares (microvena, white bear lake, mn) were unsuccessful. a second attempt performed a week later with the addition of the new ensnare (mdtech, gainesville, fl) was successful. possible causes of the migration are disc ...200314514816
polychlorinated biphenyls and reproductive hormones in female polar bears at svalbard.high concentrations of polychlorinated biphenyls (pcbs) in polar bears from svalbard have increased concern for that population's reproductive health. we examined whether there were associations between the plasma concentrations of pcbs and reproductive hormones [progesterone (p4)] and 17 beta-estradiol (e2)] in free-living female polar bears from svalbard. concentrations of p4 depended on reproductive status, and concentrations were lowest in females with offspring--females with cubs and female ...200312676595
immunohistochemical study of retinol-binding protein in livers of polar bears (thalarctos maritimus).liver tumors of unknown cause have frequently been described in polar bears. concurrent decrease of vitamin a levels and chronic liver disease are associated with hepatic carcinogenesis in humans. more than 90% of the body's vitamin a is stored in the liver, where it is bound to an intracellular retinol-binding protein (rbp). therefore, in this retrospective study, rbp was assessed by immunohistochemistry in liver sections of 11 polar bears. two of these polar bears had hepatocellular carcinoma, ...200312637760
organochlorine contaminant and stable isotope profiles in arctic fox (alopex lagopus) from the alaskan and canadian arctic.arctic fox (alopex lagopus) is a circumpolar species distributed across northern canada and alaska. arctic fox muscle and liver were collected at barrow, ak, usa (n=18), holman, nt, canada (n=20), and arviat, nu, canada (n=20) to elucidate the feeding ecology of this species and relate these findings to body residue patterns of organochlorine contaminants (ocs). stable carbon (delta 13c) and nitrogen (delta 15n) isotope analyses of arctic fox muscle indicated that trophic position (estimated by ...200312547532
variability in marine resources affects arctic fox population dynamics.terrestrial predators in coastal areas are often subsidized by marine foods. in order to determine the potential impact on terrestrial prey, the numerical response of predators to each food source must be determined. in winter, arctic foxes (alopex lagopus) may forage on the frozen arctic ocean and scavenge carcasses of seals killed by polar bears (ursus maritimus), but the importance of this food source and its effect on the population cycles of arctic foxes and lemmings (their primary prey) ar ...200330893960
pelvic inflammatory disease in the united states. incidence and trends in private practice.the national ambulatory care survey, conducted by the national center for health statistics (rockville, md.), provides national estimates for conditions diagnosed by office-based private practitioners in the united states. the venereal disease control division of the centers for disease control (atlanta, ga.) obtained data from the national ambulatory care survey for the years 1973-1976 and analyzed the epidemiology of pelvic inflammatory disease in women who sought care from private physicians. ...20047256493
[the reliability and validity of the white bear suppression inventory].the white bear suppression inventory (wbsi) is a self-report questionnaire measuring tendency to suppress unwanted intrusive thoughts. the aim of this study was to examine the reliability and validity of the wbsi in a turkish sample.200415622508
seasonal and temporal trends in polychlorinated biphenyls and organochlorine pesticides in east greenland polar bears (ursus maritimus), 1990-2001.persistent organochlorine (oc) contaminants (pcbs, ddts, chlordanes (chls), dieldrin, hexachlorocyclohexanes (hchs), chlorobenzenes (cbzs)) were determined in adipose tissue of 92 polar bears (ursus maritimus) sampled between 1999 and 2001 in central east greenland (69 degrees 00'n to 74 degrees 00'n). oc data were presented from subadults (s: females: x 5 years and males: x 6 years), adult females (f: x 5 years) and adult males (m: x 6 years). summed chlorobiphenyl (sigmacbs) concentrations (41 ...200415325144
validity and reliability of the spanish version of the white bear suppression inventory.this study examined the validity and reliability of the spanish version of the white bear suppression inventory in a sample of 833 spanish students. the internal consistency of the inventory was high (cronbach alpha = .88), and the test-retest correlation after 4 wk. was satisfactory (r = .72). pearson correlations of scores on the spanish version of the white bear suppression inventory with criterion measures (beck depression inventory, trait subscale of the state-trait anxiety inventory, and s ...200415217027
organochlorines affect the steroid hormone cortisol in free-ranging polar bears (ursus maritimus) at svalbard, norway.since the polar bear (ursus maritimus) is among the most highly organochlorine-contaminated species of the arctic mammals, there is growing concern that in addition to the natural stressors in the polar bear's environment, several organochlorines (ocs) may be able to change basic endocrine pathways. alterations in the hypothalamic-pituitary-adrenal (hpa) axis may affect plasma cortisol concentrations and inhibit physiological processes involved in the maintenance of homeostasis in a way that may ...200415205038
effects of suppressing neutral and obsession-like thoughts in normal subjects: beyond frequency.recent cognitive-behavioral theories on obsessive-compulsive disorder (ocd) show that deliberate attempts to suppress intrusive and undesirable thoughts lie at the genesis of clinical obsessions. in this paper the results of an experimental study on the suppression of neutral and obsession-like thoughts in normal subjects are presented. eighty-seven university students performed in three experimental periods: (1) base-line monitoring, (2) experimental instruction, and (3) monitoring. for each of ...200415149902
polar bears in a warming climate.polar bears (ursus maritimus) live throughout the ice-covered waters of the circumpolar arctic, particularly in near shore annual ice over the continental shelf where biological productivity is highest. however, to a large degree under scenarios predicted by climate change models, these preferred sea ice habitats will be substantially altered. spatial and temporal sea ice changes will lead to shifts in trophic interactions involving polar bears through reduced availability and abundance of their ...200421680496
don't think of a white bear: an fmri investigation of the effects of sequential instructional sets on cortical activity in a task-switching paradigm.using functional magnetic resonance imaging (fmri), we investigated processes involved in switching between two ongoing tasks, thought to be paradigmatic of executive control processes. subjects were considerably slower and less accurate when switching between two tasks than when repeatedly carrying out one task, so-called "switch costs." switch costs, however, generally occur only when more than one task is associated with each stimulus type. this has led to the surmise that switch costs may be ...200415038009
one-wire technique for performance of balloon aortic valvuloplasty.we present a new one-wire technique for balloon aortic valvuloplasty and discuss possible advantages of this technique over other techniques.200415009765
phylogeny of the bears (ursidae) based on nuclear and mitochondrial genes.the taxomic classification and phylogenetic relationships within the bear family remain argumentative subjects in recent years. prior investigation has been concentrated on the application of different mitochondrial (mt) sequence data, herein we employ two nuclear single-copy gene segments, the partial exon 1 from gene encoding interphotoreceptor retinoid binding protein (irbp) and the complete intron 1 from transthyretin (ttr) gene, in conjunction with previously published mt data, to clarify t ...200415223031
pops in polar bears: organochlorines affect bone density. 200415595176
myasthenia gravis in a polar bear (ursus maritimus).a 14.6-yr-old, female, multiparous polar bear (ursus maritimus) acutely developed an apparent hind limb weakness. physical examination and diagnostic tests including a hemogram, serum biochemistry, electrolytes, radiographs, and myelogram did not provide a definitive diagnosis. no improvement in condition was noted during 4 days of supportive care, and the bear was euthanized. an ovoid mass was present in the anterior mediastinum, and a thymoma was confirmed histologically. compared with control ...200415526902
hemoglobin, ph and dpg/chloride shifting.in this study a decreased dpg response by polar bear (ursus maritimus) hemoglobin was observed, and this response was interpreted as an example of gradual dpg/chloride shifting. this sort of mechanism has been suggested to occur in ruminants and, intuitively, one might guess that for ruminants the dpg/cl- shifting might have been beneficial and hence selected for at the time of the latest ice age. however, suggestion that this is purely a temperature effect in polar bears and ruminants conflicts ...200415667943
trends in fluctuating asymmetry in east greenland polar bears (ursus maritimus) from 1892 to 2002 in relation to organohalogen pollution.fluctuating asymmetry (fa) was studied in skulls of 283 polar bears (ursus maritimus) sampled in east greenland from 1892 to 2002. fourteen metric bilateral traits in skull and lower jaw were measured and compared between polar bears born until 1960 (n = 94) and from 1961 (n = 189). the period 1892-1960 was chosen to represent a period prior to appearance of organohalogens (polychlorinatedbiphenyls [pcbs], dichlorodiphenyltrichloroethanes [ddts], hexacyclohexanes [hchs], chlordanes [chls], hexac ...200415833243
antibodies to canine distemper and phocine distemper viruses in polar bears from the canadian arctic.serum samples collected from 200 polar bears (ursus marititnus) from two populations in the canadian arctic, the western hudson bay and lancaster sound populations, between 1989 and 1996, were tested for antibodies to canine distemper (cdv) and phocine distemper viruses (pdv) using virus neutralization. antibodies to cdv and pdv were detected in 48 and six polar bears, respectively. all six bears that tested positive for pdv also tested positive for cdv; in only one case did the antibody titer f ...200415362838
hydroxylated and methyl sulfone pcb metabolites in adipose and whole blood of polar bear (ursus maritimus) from east greenland.persistent methyl sulfone (meso2-) and hydroxylated (ho-) polychlorinated biphenyl (pcb) metabolites have emerged as important classes of environmental contaminants in vertebrate, aquatic biota and humans. in the present study, pcb, meso2-pcb and ho-pcb concentrations and congener patterns were determined in the whole blood and adipose tissue of male (n = 7) and female (n = 12) polar bears (ursus maritimus) of random age (3-25 years of age), and collected in 1999-2001 from the ittoqqortoormiit/s ...200415325145
dietary composition in greenland 2000, plasma fatty acids and persistent organic pollutants.human exposure to pollution in the arctic presents a potential future health risk for the local populations. epidemiological studies in greenland have shown that human blood levels of several organic contaminants are very high, especially in the north where people depend on local food. in east greenland (ittoqqortoormiit (scoresbysund)) the population shows the highest blood levels of several persistent organic pollutants found in arctic countries, especially pcb, the levels of which exceed cana ...200415325148
antibodies to selected pathogens in free-ranging terrestrial carnivores and marine mammals in canada.antibody titres to selected pathogens (canine adenovirus [cav-2], feline herpesvirus [fhv], phocine herpesvirus [phv-1], canine distemper virus, dolphin morbillivirus [dmv], phocine distemper virus [pdv], parainfluenza virus type 3 [pi3], rabies virus, dolphin rhabdovirus [drv], canine coronavirus, feline coronavirus, feline leukaemia virus, borrelia burgdorferi and toxoplasma gondii) were determined in whole blood or serum samples from selected free-ranging terrestrial carnivores and marine mam ...200415338705
intralobular distribution of vitamin a-storing lipid droplets in hepatic stellate cells with special reference to polar bear and arctic fox.we examined the liver of adult polar bears, arctic foxes, and rats by gold chloride staining, fluorescence microscopy for the detection of autofluorescence of vitamin a, hematoxylin-eosin staining, staining with masson's trichrome, ishii and ishii's silver impregnation, and transmission electron microscopical morphometry. the liver lobules of the arctic animals showed a zonal gradient in the storage of vitamin a. the density (i.e., cell number per area) of hepatic stellate cells was essentially ...200414960168
does high organochlorine (oc) exposure impair the resistance to infection in polar bears (ursus maritimus)? part i: effect of ocs on the humoral immunity.this study was undertaken to assess if high levels of organochlorines (ocs) are associated with decreased ability to produce antibodies in free-ranging polar bears (ursus maritimus) and thus affect the humoral immunity. in 1998 and 1999, 26 and 30 polar bears from svalbard, norway, and churchill, canada, respectively, were recaptured 32-40 d following immunization with inactivated influenza virus, reovirus, and herpes virus and tetanus toxoid. blood was sampled at immunization and at recapture f ...200415129552
is bone mineral composition disrupted by organochlorines in east greenland polar bears (ursus maritimus)?we analyzed bone mineral density (bmd) in skulls of polar bears (ursus maritimus) (n = 139) from east greenland sampled during 1892-2002. our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (pcbs), dichlorodiphenyl trichloroethane (ddt) and its metabolites, chlordanes (chls), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (pbde) compounds. to ensure that the bm ...200415579418
structure and function of hepatic stellate cells.hepatic stellate cells (vitamin a-storing cells, lipocytes, interstitial cells, fat-storing cells, ito cells) exist in the space between parenchymal cells and sinusoidal endothelial cells of the hepatic lobule and store 80% of retinoids in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. in physiological conditions, these cells play pivotal roles in the regulation of retinoid homeostasis; they express specific receptors for retinol-binding protein (rbp), a binding protein ...200415057600
relationships between pcbs and thyroid hormones and retinol in female and male polar bears.we studied the relationships between polychlorinated biphenyls (pcbs) and thyroid hormones (ths) and retinol within two groups of female polar bears (ursus maritimus), females with cubs of the year (fwcoy) and females without cubs of the year (fwocoy), and within a group of males. concentrations of five of the six quantified pcb congeners, i.e., pcb-99, pcb-153, pcb-156, pcb-180, pcb-194 (sigma pcb5), correlated with each other, whereas the concentrations of pcb-118 did not correlate with the ot ...200415175168
histology of selected immunological organs in polar bear (ursus maritimus) from east greenland in relation to concentrations of organohalogen contaminants.samples of lymph nodes (axillary, n = 54 and inguinal, n = 45), spleen (n = 60), thymus (n = 11) and thyroid tissue (n = 5) from a total of 82 polar bears (ursus maritimus) collected in east greenland 1999-2002 were examined histologically. the purpose was to relate histology to concentrations of organohalogen contaminants (ohcs) [i.e., sum (sigma)pcbs, sigmaddts, sigmahchs, sigmachls, hcb, dieldrin and sigmapbdes] determined in adipose tissue, as studies on polar bears have indicated that some ...200415833246
serum lipid concentrations in six canid and four ursid species in four zoos.serum lipid levels were measured in healthy captive wild canids and ursids, and the values were compared with previously published data. serum lipid levels were evaluated in blood samples collected from eight african wild dogs (lycaon pictus), three arctic foxes (alopex lagopus), nine gray wolves (canis lupus), four maned wolves (chrysocyon brachyurus), two mexican wolves (canis lupus baleiyi), nine red wolves (canis rufus), two brown bears (ursus arctos), six polar bears (ursus maritimus), six ...200415193071
degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids.human and animal tissues collected in urban and remote global locations contain persistent and bioaccumulative perfluorinated carboxylic acids (pfcas). the source of pfcas was previously unknown. here we present smog chamber studies that indicate fluorotelomer alcohols (ftohs) can degrade in the atmosphere to yield a homologous series of pfcas. atmospheric degradation of ftohs is likely to contribute to the widespread dissemination of pfcas. after their bioaccumulation potential is accounted for ...200415260330
isolating isomers of perfluorocarboxylates in polar bears (ursus maritimus) from two geographical locations.the source of involatile, anthropogenic perfluorocarboxylate anions (pfcas) in biota from remote regions is of heightened interest due to the persistence, toxicity, and bioaccumulation of these materials. large-scale production of fluorinated compounds is carried out primarily by one of two methods: electrochemical fluorination (ecf) and telomerization. products of the two processes may be distinguished based on constitutional isomer pattern as ecf products are characteristically comprised of a ...200415669310
levels and spatial and temporal trends of contaminants in greenland biota: an updated review.knowledge of contaminant levels in greenland biota has increased substantially in recent years, particularly for persistent organic pollutants. this paper reviews and updates knowledge of spatial and temporal trends of cd, hg and organochlorines (pcbs, ddts, hchs, hcb and chlordane-related compounds) in greenland terrestrial, freshwater and marine biota. the most comprehensive studies of spatial trends of cd and hg in the terrestrial ecosystem concern lichens, with relatively complete coverage, ...200415325140
comparative serological evaluation of 10 blastomyces dermatitidis yeast phase lysate antigens from different sources.yeast phase lysate antigens from 10 isolates of blastomyces dermatitidis (dog, erc-2 and t-58; t-27, polar bear; woodpile, er-3; bat lung, 48938; human, b5929, b5895, b5896, b5931, and capp) from different geographical regions, in addition to a histoplasma capsulatum (g217b) lysate preparation were compared with respect to their reactivity against serum specimens from dogs, rabbits and humans positive for blastomycosis using an indirect enzyme-linked immunosorbent assay. in addition, the lysate ...200415078431
congener-specific accumulation and food chain transfer of polybrominated diphenyl ethers in two arctic food chains.congener-specific accumulation and prey to predator transfer of 22 polybrominated diphenyl ethers (pbdes) were assessed in polar cod, ringed seal, polar bear, and beluga whale. although the concentrations found were relatively low, these results show that pbdes have reached the arctic. pbde congeners 47, 99, and 100 were dominant in all species studied. the pattern in ringed seal was somewhat simpler than in polar cod, with pbde 47 accounting for more than 90% of the total pbdes. in contrast, be ...200415074673
identification of long-chain perfluorinated acids in biota from the canadian arctic.recently it was discovered that humans and animals from various urban and remote global locations contained a novel class of persistent fluorinated contaminants, the most pervasive of which was perfluorooctane sulfonate (pfos). lower concentrations of perfluorooctanoate, perfluorohexane sulfonate, and heptadecafluorooctane sulfonamide have also been detected in various samples. although longer perfluoroalkyl carboxylates (pfcas) are used in industry and have been detected in fish following a spi ...200414750710
identification and characterization of tandem repeats in exon iii of dopamine receptor d4 (drd4) genes from different mammalian species.in this study we have identified and characterized dopamine receptor d4 (drd4) exon iii tandem repeats in 33 public available nucleotide sequences from different mammalian species. we found that the tandem repeat in canids could be described in a novel and simple way, namely, as a structure composed of 15- and 12- bp modules. tandem repeats composed of 18-bp modules were found in sequences from the horse, zebra, onager, and donkey, asiatic bear, polar bear, common raccoon, dolphin, harbor porpoi ...200516332176
an immunohistochemical study of retinol-binding protein (rbp) in livers of free-living polar bears (ursus maritimus) from east greenland.from 1999 to 2002 samples from 114 free-ranging polar bears (ursus maritimus) were collected in the municipality of scoresby sound, east greenland, to detect levels of organochlorines and potential histopathologic changes. livers of 16 female polar bears from this group were evaluated histologically and analyzed for hepatic retinol-binding protein by immunohistochemistry. retinol-binding protein is the main transport protein for retinol, an important vitamin a metabolite in the polar bear. only ...200517312762
serosurvey of selected zoonotic agents in polar bears (ursus maritimus).between 1982 and 1999 blood samples were collected from 500 polar bears (ursus maritimus) captured in the beaufort and chukchi seas, to determine the seroprevalence of brucella species, toxoplasma gondii, and trichinella species infections. the bears were classified into four age groups, cubs, yearlings, subadults and adults. brucella and toxoplasma antibodies were detected by agglutination (a buffered acidified card antigen and rapid automated presumptive test for brucellosis and a commercial l ...200515658561
perflouroalkyl contaminants in liver tissue from east greenland polar bears (ursus maritimus).perfluoroalkyl substances were determined in polar bears (ursus maritimus) collected in east greenland (69 degrees 00'n to 74 degrees 00"n) to compare with other populations and to examine effects of age and gender on concentrations of these contaminants. hepatic tissue (n = 29) was analyzed for perfluorooctane sulfonate (pfos), perfluorooctanoate (pfoa), perfluorohexane sulfonate, heptadecafluorooctane sulfonamide (pfosa), and perfluoroalkyl carboxylates (pfcas) with c9-c15 perfluorinated carbo ...200515839574
vessel wall damage caused by cerebral protection devices: ex vivo evaluation in porcine carotid arteries.to determine the extent of vessel wall damage caused by cerebral protection devices designed for carotid angioplasty by using ex vivo porcine carotid arteries.200515858088
does high organochlorine (oc) exposure impair the resistance to infection in polar bears (ursus maritimus)? part ii: possible effect of ocs on mitogen- and antigen-induced lymphocyte proliferation.previous studies have reported alarmingly high levels of organochlorines (ocs), particularly polychlorinated biphenyls (pcbs), in free-ranging polar bears (ursus maritimus). in this study plasma concentration of pcbs ranged from 14.8 to 200 ng/g wet weight. the aim of the study was to investigate associations between ocs and lymphocyte proliferation after in vitro stimulation with different mitogens and antigens. in 1998 and 1999, 26 and 30 free-ranging polar bears from svalbard and churchill, c ...200515799246
an assessment of the toxicological significance of anthropogenic contaminants in canadian arctic wildlife.anthropogenic contaminants have been a concern in the canadian arctic for over 30 years due to relatively high concentrations of bioaccumulating and biomagnifying organochlorine contaminants (ocs) and toxic metals found in some arctic biota and humans. however, few studies have addressed the potential effects of these contaminants in canadian arctic wildlife. prior to 1997, biological effects data were minimal and insufficient at any level of biological organization. the present review summarize ...200516154621
flame retardants and methoxylated and hydroxylated polybrominated diphenyl ethers in two norwegian arctic top predators: glaucous gulls and polar bears.the brominated flame retardants have been subject of a particular environmental focus in the arctic. the present study investigated the congener patterns and levels of total hexabromocyclododecane (hbcd), polybrominated biphenyls, polybrominated diphenyl ethers (pbdes), as well as methoxylated (meo) and hydroxylated (oh) pbdes in plasma samples of glaucous gulls (larus hyperboreus) and polar bears (ursus maritimus) from the norwegian arctic. the analyses revealed the presence of total hbcd (0.07 ...200516173559
polycyclic musk compounds in higher trophic level aquatic organisms and humans from the united states.polycyclic musks, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (hhcb) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (ahtn), are used as fragrance ingredients in numerous consumer products such as cleaning agents and personal care products. studies have reported the widespread occurrence of these musks in surface waters and fish from western european countries. nevertheless, little is known about their accumulation in humans and wildlife in the united ...200516219504
do organohalogen contaminants contribute to histopathology in liver from east greenland polar bears (ursus maritimus)?in east greenland polar bears (ursus maritimus), anthropogenic organohalogen compounds (ohcs) (e.g., polychlorinated biphenyls, dichlorodiphenyltrichloroethane, and polybrominated diphenyl ethers) contributed to renal lesions and are believed to reduce bone mineral density. because ohcs are also hepatotoxic, we investigated liver histology of 32 subadult, 24 adult female, and 23 adult male east greenland polar bears sampled during 1999-2002. light microscopic changes consisted of nuclear displac ...200516263513
helicobacter spp. from captive bottlenose dolphins (tursiops spp.) and polar bears (ursus maritimus).the gastric fluid of six bottlenose dolphins and the faeces of four polar bears from the same oceanarium were examined for the presence of helicobacter. as detected by pcr, all dolphins and 8/12 samples collected from polar bears were positive for helicobacter. novel sequence types were identified in samples collected from these animals of which several were unique to either the dolphins or the polar bears. at least one sequence type was, however, detected in both animal taxa. in addition, a seq ...200516266854
determination of hydroxylated polychlorinated biphenyls (ho-pcbs) in blood plasma by high-performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry.hydroxylated metabolites of polychlorinated biphenyls (ho-pcbs) and pentachlorophenol (pcp) are halogenated phenolic compounds, and they are increasingly common as environmental contaminants mainly in the blood of wildlife and humans. a methodology based on high-performance liquid chromatography (reversed-phase)-electrospray (negative) ionization-tandem quadrupole mass spectrometry (lc-esi(-)-ms-ms) in the select ion monitoring or multiple reaction monitoring modes was developed for ho-pcb and p ...200515975248
outbreak of trichinellosis associated with consumption of game meat in west greenland.the inuit population of the arctic has always been at risk of acquiring trichinellosis and severe outbreaks have been recorded in alaska and canada. in west greenland, a number of large outbreaks took place during the 1940s and 1950s; they involved total 420 cases including 37 deaths. since then only sporadic cases have been reported. here, we describe an outbreak of infection with trichinella spp. after consumption of infected meat presumably from walrus or polar bear caught in western greenlan ...200516023294
serologic survey for selected virus infections in polar bears at svalbard.polar bears (ursus maritimus) were chemically immobilized and sampled at svalbard, norway, and on the pack ice in the barents sea from late march to mid-may between 1990 and 1998. plasma samples were tested for the presence of antibodies to canine distemper virus (cdv), calicivirus, phocid herpesvirus type 1 (phhv-1), and rabies virus. a seroprevalence of 8% to cdv and 2% to calicivirus were found, whereas no antibodies were detected against phhv-1 or rabies virus. this serologic survey indicate ...200516107665
chlorinated hydrocarbon contaminants and metabolites in polar bears (ursus maritimus) from alaska, canada, east greenland, and svalbard: 1996-2002.a suite of chlorinated hydrocarbon contaminants (chcs) including organochlorine pesticides (ocps) and by-products, polychlorinated biphenyls (pcbs), and methyl sulfone (meso2) pcb and p,p'-dichlorodiphenyldichloroethylene (p,p'-dde) metabolites were determined in adipose tissue of 107 adult and sub-adult polar bears, almost exclusively females, sampled between 1996 and 2002 from populations spanning arctic and subarctic regions of alaska, canada, east greenland, and svalbard. the east greenland ...200516115663
enlarged clitoris in wild polar bears (ursus maritimus) can be misdiagnosed as pseudohermaphroditism.a 23-year-old female polar bear (ursus maritimus) killed in an inuit hunt in east greenland on july 9, 1999 had a significantly enlarged clitoris resembling, in size, form and colour, those of previously reported 'pseudohermaphroditic' polar bears from svalbard. it has been suggested that an enzyme defect (21-hydroxylase deficiency), androgen producing tumour or high exposure to organochlorines during the foetal stage or early development could be the reason for the supposed pseudohermaphroditis ...200515626378
adaptation of the hindlimbs for climbing in bears.the hindlimbs of the malayan sun bear (helarctos malayanus), the polar bear (ursus maritimus), the brown bear (ursus arctos) and the giant panda (ailuropoda melanoleuca) have been anatomically and osteometrically studied. the musculus tibialis cranialis of the malayan sun bear and the giant panda possessed a well-developed rich fleshy portion until the distal end of the tibia. in the polar bear and the brown bear, however, the fleshy portion of the m. tibialis cranialis was not developed until t ...200515900701
gull eggs--food of high organic pollutant content?a wide range and occasionally high levels of persistent organic pollutants (pops) are reported in arctic regions, especially among top predators. polar bears (ursus maritimus), arctic foxes (alopex lagopus) and some gull species (larus spp.) often have high levels of these fat-soluble pollutants. gulls deposit significant levels of these contaminants in their eggs. in northern regions, gull eggs are part of the traditional human diet. in the present study we have investigated the levels of pops ...200515931427
recent climate change in the arctic and its impact on contaminant pathways and interpretation of temporal trend data.the arctic has undergone dramatic change during the past decade. the observed changes include atmospheric sea-level pressure, wind fields, sea-ice drift, ice cover, length of melt season, change in precipitation patterns, change in hydrology and change in ocean currents and watermass distribution. it is likely that these primary changes have altered the carbon cycle and biological systems, but the difficulty of observing these together with sporadic, incomplete time series makes it difficult to ...200515866268
sulfonation of environmental chemicals and their metabolites in the polar bear (ursus maritimus).although its habitat comprises mostly remote regions of the arctic, the polar bear is subject to bioaccumulation of persistent environmental pollutants. along with their phase i metabolites, they are potential substrates for detoxification via sulfonation and glucuronidation. the capability of polar bear liver to sulfonate a structurally diverse group of environmental chemicals, that is, 3-hydroxybenzo[a]pyrene (3-oh-b[a]p), triclosan, 4'-hydroxy-3,3',4,5'-tetrachlorobiphenyl (4'oh-pcb79), 4'-hy ...200515951448
persistent organic pollutants and mercury in marine biota of the canadian arctic: an overview of spatial and temporal trends.this review summarizes and synthesizes the significant amount of data which was generated on mercury (hg) and persistent organic pollutants (pops) in canadian arctic marine biota since the first canadian arctic contaminants assessment report (cacar) was published in 1997. this recent body of work has led to a better understanding of the current levels and spatial and temporal trends of contaminants in biota, including the marine food species that northern peoples traditionally consume. compared ...200516109439
preliminary screening of perfluorooctane sulfonate (pfos) and other fluorochemicals in fish, birds and marine mammals from greenland and the faroe islands.extensive screening analyses of perfluorooctane sulfonate (pfos) and related perfluorinated compounds in biota samples from all over the world have identified pfos as a global pollutant and have shown its bioaccumulation into higher trophic levels in the food chain. perfluorinated compounds have been found in remote areas as the arctic. in this study a preliminary screening of pfos and related compounds has been performed in liver samples of fish, birds and marine mammals from greenland and the ...200515840540
monorail snare technique for the recovery of stretched platinum coils: technical case report.coil stretching represents a potentially hazardous technical complication not infrequently encountered during the embolization of cerebral aneurysms. often, the stretched coil cannot be advanced into the aneurysm or withdrawn intact. the operator is then forced to attempt to retract the damaged coil, which may result in coil breakage, leaving behind a significant length of potentially thrombogenic stretched coil material within the parent vessel. to overcome this problem, we devised a technique ...200515987594
chlorinated, brominated, and perfluorinated contaminants in livers of polar bears from alaska.the existence of two subpopulations of polar bears in alaska, the beaufort sea and the chukchi sea populations, has been documented. in this study, differences in concentrations and profiles of organochlorine pesticides, polychlorinated biphenyls (pcbs), polybrominated diphenyl ethers (pbdes), and perfluorinated acids were examined in livers of polar bears from the two subpopulations in alaska. concentrations of most of the organohalogens analyzed were greater in the beaufort sea subpopulation t ...200516382925
reduced autobiographical memory specificity as an avoidant coping style.previous studies suggest that reduced autobiographical memory specificity might serve as a way of regulating affect. this study examined the relationship between autobiographical memory specificity and avoidant coping.200516368035
are polar bears threatened? 200516166501
circumpolar study of perfluoroalkyl contaminants in polar bears (ursus maritimus).perfluoroalkyl substances were determined in liver tissues and blood of polar bears (ursus maritimus) from five locations in the north american arctic and two locations in the european arctic. concentrations of perfluorooctane sulfonate (pfos), perfluorohexane sulfonate, heptadecafluorooctane sulfonamide, and perfluoroalkyl carboxylates with c(8)-c(15) perfluorinated carbon chains were determined using liquid chromatography tandem mass spectrometry. pfos concentrations were significantly correla ...200516124282
x-sizer for thrombectomy in acute myocardial infarction improves st-segment resolution: results of the x-sizer in ami for negligible embolization and optimal st resolution (x amine st) trial.we sought to compare, in a prospective randomized multicenter study, the effect of adjunctive thrombectomy using x-sizer (ev3, white bear lake, minnesota) before percutaneous coronary intervention (pci) versus conventional pci in patients with acute myocardial infarction (ami) for <12 h and thrombolysis in myocardial infarction (timi) flow grade 0 to 1. the primary end point was the magnitude of st-segment resolution after pci.200516022950
behavioral decisions for managing social distance and aggression in captive polar bears (ursus maritimus).the polar bear (ursus maritimus) in most zoos attracts high levels of public attention and can play an important role in conservation education. polar bears in the wild are typically solitary; bears in captivity often house socially. this study reported behavioral evidence on how bears manage this situation and whether proximity leads to aggression. the study recorded location and behavior once per minute for 106 hr for 2 female polar bears at the philadelphia zoo; the samples represented all ti ...200617112334
density functional theory for hard-sphere mixtures: the white bear version mark ii.in the spirit of the white bear version of fundamental measure theory we derive a new density functional for hard-sphere mixtures which is based on a recent mixture extension of the carnahan-starling equation of state. in addition to the capability to predict inhomogeneous density distributions very accurately, like the original white bear version, the new functional improves upon consistency with an exact scaled-particle theory relation in the case of the pure fluid. we examine consistency in d ...200621690897
individual differences in self-reported thought control: the role of the repressive coping sytle.the purpose of the present research is to assess differences between repressors and non repressors in some aspects associated with conscious thought control. thus, sixty-three spanish university students with different combinations of trait anxiety and defensiveness completed the thought control ability questionnaire (tcaq) and the white bear suppression inventory (wbsi). data analysis showed that subjects with low anxiety (repressors and low anxious) reported higher perceived ability to control ...200617296036
composition of chlorinated hydrocarbon contaminants among major adipose tissue depots of polar bears (ursus maritimus) from the canadian high arctic.monitoring of environmental contaminants in canadian arctic polar bears (ursus maritimus) typically has used superficial adipose tissue samples collected as part of controlled native subsistence hunts. however, little attention has been paid to the compositional difference in contaminants that may exist among the major adipose depots that are routinely collected. to address this knowledge gap, we investigated the profiles and concentrations of chlorinated hydrocarbon contaminants (chcs), includi ...200616978684
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