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validation of an automated elisa system for detection of antibodies to aleutian mink disease virus using blood samples collected in filter paper strips.aleutian mink disease virus (amdv) is the cause of a chronic immune complex disease, aleutian disease (ad), which is common in mink-producing countries. in 2005, implementation of an amdv eradication programme in finland created a need for an automated high-throughput assay. the aim of this study was to validate an amdv-vp2 -recombinant antigen elisa, which we developed earlier, in an automated assay format for the detection of anti-amdv antibodies in mink blood and to determine the accuracy of ...201425103400
testing for aleutian mink disease virus in the river otter (lontra canadensis) in sympatry with infected american mink (neovison vison).aleutian mink disease virus (amdv) occurs in the american mink (neovison vison) in wild populations and on mink farms and can cause illness and death. the north american river otter (lontra canadensis) may be exposed to amdv because of shared space and habitat with mink. using serology and real-time pcr, we tested river otters across ontario for amdv infection. we found no evidence of infection in otters, a surprising finding given the sympatric distribution, niche overlap, and close phylogeneti ...201424807350
molecular characterization of the small nonstructural proteins of parvovirus aleutian mink disease virus (amdv) during infection.aleutian mink disease virus (amdv) is the only member in genus amdovirus of the family parvoviridae. during amdv infection, six species of viral transcripts are generated from one precursor mrna through alternative splicing and alternative polyadenylation. in addition to the large non-structural protein ns1, two small non-structural proteins, ns2 and ns3, are putatively encoded (qiu j, et al., 2006. j. virol. 80 654-662). however, these two proteins have not been experimentally demonstrated duri ...201424606679
molecular epidemiology of aleutian mink disease virus in china.aleutian mink disease (mink plasmacytosis) is a very severe immune-complex-mediated disease affecting minks. it is caused by the aleutian mink disease virus (amdv). to obtain a better understanding of the molecular epidemiology of amdv in china, a total of 420 samples were collected from mink farms in five major mink-farming provinces in china. after testing serum antibodies using counterimmunoelectrophoresis (ciep), 23 of the 340 positive samples were randomly selected and analyzed. the full le ...201424561116
diagnosing aleutian mink disease infection by a new fully automated elisa or by counter current immunoelectrophoresis: a comparison of sensitivity and specificity.aleutian disease (ad) is a severe disease characterized by hypergammaglobulinemia causing multiple symptoms such as acute renal failure, arteritis, reduced reproductive performance and pneumonia in mink. ad is caused by the parvovirus aleutian mink disease virus (adv) and diagnosed primarily based on adv serology sometimes supplemented by organ pcr analysis. in denmark, approximately 3.5-4 million serum samples are tested every year for the presence of anti adv antibodies as part of a national e ...201424462658
monitoring chronic infection with a field strain of aleutian mink disease virus.aleutian mink disease virus (amdv) readily spread within farmed mink and causes chronic infections with significant impacts for welfare and economy. in the present study a currently circulating danish amdv strain was used to induce chronic experimental infection of farmed mink. pcr was used to detect viral dna in full blood, organs, faeces and oro-nasal swabs weekly for the first 8 weeks and then biweekly for another 16 weeks after amdv challenge inoculation of wild type mink. the mink (n=29) wa ...201424389253
[sequencing analyses of the hypervariable region within the vp2 gene of a strain of the aleutian mink disease virus].to analyze the molecular mechanisms of cross-host transmission of the aleutian mink disease vi rus (adv), the hypervariable region fragment of the vp2 gene of the adv in jilin province (china) was amplified. sequencing analyses showed diversity at residue 174 by comparison with other vp2 genes in genbank. the phylogenetic tree indicated that the adv-jl strain had a close relationship with the highly pathogenic strain from denmark: adv-k. results implied that residue 174 may be associated with ad ...201526470526
detection of aleutian disease virus by loop-mediated isothermal amplification.in this study, a loop-mediated isothermal amplification (lamp) assay was developed and optimized for the detection of aleutian disease virus (adv) in minks. the amplification could be completed within 45 min under isothermal condition by employing a set of six adv genome-specific primers. the amplification results could be visualized directly with the naked eye by using fluorescent dye. comparative experiments showed that the lamp assay is superior to conventional polymerase chain reaction for t ...201526396989
[research into the antibody detection technology of mink plasmacytosis and its current applications].mink plasmacytosis, caused by aleutian mink disease virus (amdv), poses a threat to the development of the animal fur industry. neutralizing antibodies against amdv may result in a persistent infection rather than providing protection for minks. to date,no specific methods to prevent or cure this disease have been developed. in order to eliminate mink plasmacytosis, antibody detection technology has been used globally as a dominant approach to screen for amdv-positive minks. this paper introduce ...201525997336
detection of aleutian mink disease virus dna and antiviral antibodies in american mink (neovison vison) 10 days postinoculation.early detection of infection by the aleutian mink disease virus (amdv; carnivore amdoparvovirus 1) by polymerase chain reaction (pcr) or counterimmunoelectrophoresis (ciep) has important ramifications in virus eradication programs. a spleen homogenate containing a local isolate of amdv was injected intraperitoneally into black (n = 44) and sapphire (n = 12) american mink (neovison vison). animals were euthanized 10 days postinoculation and anti-amdv antibodies and amdv dna were tested in plasma ...201525862712
aleutian mink disease virus in free-ranging mink from sweden.aleutian mink disease (amd) is a chronic viral disease in farmed mink and the virus (amdv) has been found in many free-ranging mink (neovison vison) populations in europe and north america. in this study, amdv dna and amdv antibodies were analysed in 144 free-ranging mink hunted in sweden. associations between being amdv infected (defined as positive for both viral dna and antibodies) and the weight of the spleen, liver, kidneys, adrenal glands and body condition were calculated and the sequence ...201525822750
aleutian mink disease virus in free-ranging mustelids in finland - a cross-sectional epidemiological and phylogenetic study.aleutian mink disease virus (amdv) can cause severe immune-complex-mediated disease in american mink. amdv has also been detected in several other mustelid species with potential negative impact on their health and population. a molecular and cross-sectional epidemiological study was conducted to obtain data on the prevalence, distribution, transmission and diversity of amdv strains in finnish free-ranging mustelids and risk factors associated with infection. the presence of anti-amdv antibodies ...201525667324
aleutian mink disease virus in striped skunks (mephitis mephitis): evidence for cross-species spillover.aleutian mink disease virus (amdv) causes a parvovirus infection, initially characterized in american mink (neovison vison), that may have harmful effects on wild populations of susceptible animals. in north america, where american mink are native, the origin, host range, and prevalence of amdv in wild species is not clear. we studied striped skunks (mephitis mephitis) and raccoons (procyon lotor) to determine whether species sympatric with mink are potential reservoirs in the transmission of am ...201525647590
molecular epidemiology of aleutian mink disease virus (amdv) in estonia, and a global phylogeny of amdv.aleutian mink disease virus (amdv) causes a severe disease called aleutian disease (ad). amdv infects primarily mustelids, but also other mammal species. recent evidence suggests that amdv may also affect humans. to examine amdv in different wild animals and in farmed mink in estonia, we collected 203 blood samples from eight mammal species in 2007-2010, of which 152 were from species living in the wild (american mink, european mink, pine marten, polecat, raccoon dog, badger, otter, and stone ma ...201525616049
development of a nanoparticle-assisted pcr (nanopcr) assay for detection of mink enteritis virus (mev) and genetic characterization of the ns1 gene in four chinese mev strains.mink enteritis virus (mev) causes mink viral enteritis, an acute and highly contagious disease whose symptoms include violent diarrhea, and which is characterized by high morbidity and mortality. nanoparticle-assisted polymerase chain reaction (nanopcr) is a recently developed technique for the rapid detection of bacterial and viral dna. here we describe a novel nanopcr assay for the clinical detection and epidemiological characterization of mev.201525582057
aleutian disease: an emerging disease in free-ranging striped skunks (mephitis mephitis) from california.aleutian disease virus (adv, amdovirus, parvoviridae) primarily infects farmed mustelids (mink and ferrets) but also other fur-bearing animals and humans. three aleutian disease (ad) cases have been described in captive striped skunks; however, little is known about the relevance of ad in free-ranging carnivores. this work describes the pathological findings and temporospatial distribution in 7 cases of ad in free-ranging striped skunks. all cases showed neurologic disease and were found in a 46 ...201525445322
amdoparvoviruses in small mammals: expanding our understanding of parvovirus diversity, distribution, and pathology.many new viruses have been discovered recently, thanks in part to the advent of next-generation sequencing technologies. among the parvoviridae, three novel members of the genus amdoparvovirus have been described in the last 4 years, expanding this genus that had contained a single species since its discovery, aleutian mink disease virus. the increasing number of molecular and epidemiological studies on these viruses around the world also highlights the growing interest in this genus. some aspec ...201526528267
development of a peptide elisa for the diagnosis of aleutian mink disease.aleutian disease (ad) is a common immunosuppressive disease in mink farms world-wide. since the 1980s, counterimmunoelectrophoresis (ciep) has been the main detection method for infection with the aleutian mink disease virus (amdv). in this study, six peptides derived from the amdv structural protein vp2 were designed, synthesized, and used as elisa antigens to detect anti-amdv antibodies in the sera of infected minks. serum samples were collected from 764 minks in farms from five different prov ...201627802320
driving forces behind the evolution of the aleutian mink disease parvovirus in the context of intensive farming.aleutian mink disease virus (amdv) causes plasmacytosis, an immune complex-associated syndrome that affects wild and farmed mink. the virus can also infect other small mammals (e.g., ferrets, skunks, ermines, and raccoons), but the disease in these hosts has been studied less. in 2007, a mink plasmacytosis outbreak began on the island of newfoundland, and the virus has been endemic in farms since then. in this study, we evaluated the molecular epidemiology of amdv in farmed and wild animals of n ...201627774297
identification of a novel aleutian mink disease virus b-cell epitope using a monoclonal antibody against vp2 protein.aleutian mink disease virus (amdv) is a parvovirus that causes an immune complex-mediated disease in minks. capsid protein vp2 is a major structural viral protein and can be used to diagnose amdv. in this study, a specific monoclonal antibody, 1m13, was produced against the amdv vp2 protein (amino acids 291-502). a linear vp2-protein epitope was identified by subjecting a series of partially overlapping synthesized peptides to be enzyme-linked immunosorbent assay (elisa) analysis. the results in ...201627354304
accuracy of enzyme-linked immunosorbent assays for quantification of antibodies against aleutian mink disease virus.there is a growing interest among mink ranchers to select their stock for tolerance to the aleutian mink disease virus (amdv). enzyme-linked immunosorbent assays (elisa) are used to identify mink which have low anti-amdv antibody titres and are expected to tolerate the amdv infection. the objective of this study was to calculate the accuracy of three elisa systems which were performed on blood or serum of amdv-inoculated american mink (neovison vison) at five laboratories in canada, usa, finland ...201627283885
progression of experimental chronic aleutian mink disease virus infection.aleutian mink disease virus (amdv) is found world-wide and has a major impact on mink health and welfare by decreasing reproduction and fur quality. in the majority of mink, the infection is subclinical and the diagnosis must be confirmed by serology or polymerase chain reaction (pcr). increased knowledge based on a systematically description of clinical signs, pathology and histopathology might be a tool to reduce the risk of infection from subclinically infected mink to amdv free herds. the ai ...201627250118
a fast and robust method for whole genome sequencing of the aleutian mink disease virus (amdv) genome.aleutian mink disease virus (amdv) is a frequently encountered pathogen associated with commercial mink breeding. amdv infection leads to increased mortality and compromised animal health and welfare. currently little is known about the molecular evolution of the virus, and the few existing studies have focused on limited regions of the viral genome. this paper describes a robust, reliable, and fast protocol for amplification of the full amdv genome using long-range pcr. the method was used to g ...201627060623
genetic characterization of the complete genome of an aleutian mink disease virus isolated in north china.the genome of a highly pathogenic strain of aleutian disease mink virus (amdv-bj) isolated from a domestic farm in north china has been determined and compared with other strains. alignment analysis of the major structural protein vp2 revealed that amdv-bj is unique among 17 other amdv strains. compared with the nonpathogenic strain adv-g, the 3' end y-shaped hairpin was highly conserved, while a 4-base deletion in the 5' u-shaped terminal palindrome resulted in a different unpaired "bubble" gro ...201627007772
corrigendum: amdoparvoviruses in small mammals: expanding our understanding of parvovirus diversity, distribution, and pathology.[this corrects the article on p. 1119 in vol. 6, pmid: 26528267.].201626973636
development of an enzyme-linked immunosorbent assay based on fusion vp2332-452 antigen for detecting antibodies against aleutian mink disease virus.for detection of aleutian mink disease virus (amdv) antibodies, an enzyme-linked immunosorbent assay (elisa) was developed using the recombinant vp2332-452 protein as an antigen. counterimmunoelectrophoresis (ciep) was used as a reference test to compare the results of the elisa and western blotting (wb); the specificity and sensitivity of the vp2332-452 elisa were 97.9% and 97.3%, respectively, which were higher than those of wb. therefore, this vp2332-452 elisa may be a preferable method for d ...201626582828
prevalence of antibody to aleutian mink disease virus in european mink (mustela lutreola) and american mink (neovison vison) in spain.the european mink (mustela lutreola) has undergone a dramatic decline and is one of the most endangered mammals in the world. the invasive american mink (neovison vison) is considered the main factor for this decline. however, the american mink's introduction and the subsequent ecological concurrence of the two species cannot solely explain the decline or disappearance of the european mink. aleutian mink disease virus (amdv) is the main health problem in fur farming worldwide, causing varied cli ...201626528576
full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (mephitis mephitis).amdoparvovirus is a newly defined parvoviral genus that contains four species (carnivore amdoparvovirus 1-4), including the well-known aleutian mink disease virus (amdv). amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in mustelidae and caninae hosts. in this study, we molecularly investigated amdoparvoviruses detected in 44 striped skunks (mephitis mephitis) found dead in and around vancouver, british columbia, canada. some of the animals exhibited pathological cha ...201728487558
serology and protein electrophoresis for evidence of exposure to 12 mink pathogens in free-ranging american mink (neovison vison) in argentina.basic pathologic characteristics for farmed minks were previously reported worldwide. however, its status in the wild has not been studied in detail.201728635524
construction and immunogenicity analysis of whole-gene mutation dna vaccine of aleutian mink virus isolated virulent strain.aleutian mink disease (ad) is a chronic viral infection that causes autoimmune disorders in minks and presents a significant economic burden on mink farming. despite the substantial challenges presented by ad, no effective vaccine is available and only partial protection has been achieved. we constructed a whole-gene nucleic acid vaccine from an isolated virulent aleutian mink disease virus (adv) strain (pcdna3.1-adv). based on this whole-gene nucleic acid vaccine, we generated truncated mutant ...201728829241
aleutian disease virus-like virus ( amdoparvovirus sp.) infecting free-ranging striped skunks (mephitis mephitis) in the midwestern united states.aleutian disease virus (adv) and closely related (adv-like) viruses are parvoviridae members (genus amdoparvovirus) that primarily infect farmed mustelids and have been detected in humans and free-ranging carnivora from north america. we describe adv-like/ amdoparvovirus sp. infection in four free-ranging striped skunks (mephitis mephitis) from the midwestern united states.201728820299
outbreak tracking of aleutian mink disease virus (amdv) using partial ns1 gene sequencing.aleutian mink disease (amd) is an infectious disease of mink (neovison vison) and globally a major cause of economic losses in mink farming. the disease is caused by aleutian mink disease virus (amdv) that belongs to the genus amdoparvovirus within the parvoviridae family. several strains have been described with varying virulence and the severity of infection also depends on the host's genotype and immune status. clinical signs include respiratory distress in kits and unthriftiness and low qual ...201728637462
evolutionary analysis of whole-genome sequences confirms inter-farm transmission of aleutian mink disease virus.aleutian mink disease virus (amdv) is a frequently encountered pathogen associated with mink farming. previous phylogenetic analyses of amdv have been based on shorter and more conserved parts of the genome, e.g. the partial ns1 gene. such fragments are suitable for detection but are less useful for elucidating transmission pathways while sequencing entire viral genomes provides additional informative sites and often results in better-resolved phylogenies. we explore how whole-genome sequencing ...201728612703
distribution of aleutian mink disease virus contamination in the environment of infected mink farms.control and eradication of aleutian mink disease virus (amdv) are a major concern for fur-bearing animal production. despite notably reducing disease prevalence, current control programs are unable to prevent the reinfection of farms, and environmental amdv persistence seems to play a major role regarding this issue. in this study 114 samples from different areas and elements of seven infected mink farms were analyzed by qpcr in order to evaluate the environmental distribution of amdv load. samp ...201728532807
reduced severity of histopathological lesions in mink selected for tolerance to aleutian mink disease virus infection.the objective of this study was to measure the effect of selection for tolerance on the severity of the aleutian disease (ad) lesions in mink. sensitivity and specificity of antibody detection in the blood by counter-immunoelectrophoresis (ciep) relative to the presence of aleutian mink disease virus (amdv) in the spleen by pcr in naturally infected farmed mink were also estimated. carcasses of 680 sero-positive (ciep-p) black mink from 28 farms in nova scotia, canada, and from 132 sero-negative ...201728249174
a fast and accurate method of detecting aleutian mink disease virus in blood and tissues of chronically infected mink.the objective of this study was to assess the sensitivity of the omni klentaq-la dna polymerase for detecting aleutian mink disease virus (amdv) in mink blood and tissues by pcr without dna extraction. the presence of amdv dna was directly tested by klentaq in the plasma, serum, whole blood, and spleen homogenates of 188 mink 4 and 16 months after inoculation with the virus. samples from bone marrow, small intestine, liver, lungs, kidneys, and lymph nodes of 20 of the same mink were also tested ...201728177788
high molecular polymorphism of the hypervariable region in the vp2 gene of aleutian mink disease virus.parvoviruses exhibit extreme genetic plasticity. the vp2 protein, containing a hypervariable region, is of particular importance. a single nucleotide change in this part of the genome and its effect on the amino acid sequence may significantly affect the range of infected hosts, tropism for specific tissues, or virulence. the high polymorphism in the hypervariable region can be exploited for phylogenetic analysis. the aim of this study was to analyze the polymorphism of the vp2 hypervariable reg ...201727928914
beyond rabies: are free-ranging skunks (mephitis mephitis) in british columbia reservoirs of emerging infection?wild animal reservoirs are an important source of emerging and zoonotic infection. skunks (mephitis mephitis) are a reservoir of skunk strain rabies virus in canada, with the exception of some areas including the province of british columbia (bc). beyond rabies, the reservoir status of skunks for emerging and zoonotic pathogens in bc is unknown. from march 2011 to february 2015, 50 free-ranging skunks were necropsied and tested for 4 pathogens: influenza a, aleutian disease virus (adv), leptospi ...201726392297
the use of phoxim and bendiocarb for control of fleas in farmed mink (mustela vison).fleas (ceratophyllus sciurorum) are common on farmed mink in denmark. when present, the fleas have a negative impact on the health of the farmed mink and are of nuisance for farm staff. severe infestations of fleas cause anemia, poor growth and may result in death of mink kits. changed behavior of the dams is also observed. further it has been demonstrated that the fleas are vectors of aleutian disease virus. flea control is based on use of a few insecticides and resistance has been reported aga ...201830243298
amdoparvovirus infection in red pandas ( ailurus fulgens).aleutian mink disease virus is the type species in the genus amdoparvovirus, and in mink and other mustelidae can cause either subclinical disease or fatal chronic immune stimulation and immune complex disease. the authors describe a novel amdoparvovirus in the endangered red panda ( ailurus fulgens), discovered using viral metagenomics. the authors analyzed the prevalence, tissue distribution, and disease association by pcr, in situ hybridization, electron microscopy, and histology in a group o ...201829433401
development and evaluation of a direct taqman qpcr assay for the rapid detection of diverse carnivore amdoparvoviruses.amdoparvoviruses infect carnivore species, including mink, raccoon dog, fox, skunk, and red panda. amdoparvovirus infection is a major cause of morbidity and mortality in farmed minks. here, we developed a direct taqman qpcr assay for detection and quantification of carnivore amdoparvoviruses by using three primers and one probe based on the conserved vp2 gene. the detection limit for aleutian mink disease virus (amdv) and raccoon dog and arctic fox amdoparvovirus (rfav) were 4.06 × 101 copies/μ ...201931521579
a comparison between intraperitoneal injection and intranasal and oral inoculation of mink with aleutian mink disease virus.intranasal, with (ins) and without (in) sedation, and oral inoculation were compared with intraperitoneal (ip) injection for establishing infection with a local isolate of aleutian mink disease virus (amdv) in 35 american mink. blood samples were collected on 0, 21, 36 and 56 day post-inoculation (dpi). antiviral-antibodies and viral dna in plasma and tissues were measured by counter-immunoelectrophoresis (ciep) and pcr, respectively. the presence of amdv dna was tested by pcr in saliva, rectal ...201930856435
endemic skunk amdoparvovirus in free-ranging striped skunks (mephitis mephitis) in california.the genus amdoparvovirus includes the newly discovered skunk amdoparvovirus and the well-characterized aleutian disease virus which causes significant health impacts in farmed mink worldwide. in 2010-2013, an outbreak of fatal amdoparvovirus-associated disease was documented in free-ranging striped skunks (mephitis mephitis) from the san francisco bay area of california. to characterize the geographic distribution, earliest occurrence and abundance of this virus, as well as possible impacts on s ...201931206251
molecular epidemiology of aleutian mink disease virus causing outbreaks in mink farms from southwestern europe: a retrospective study from 2012 to 2019.aleutian mink disease virus (amdv) causes major economic losses in fur-bearing animal production. the control of most amdv outbreaks is complex due to the difficulties of establishing the source of infection based only on the available on-farm epidemiological data. in this sense, phylogenetic analysis of the strains present in a farm may help elucidate the origin of the infection and improve the control and biosecurity measures.202032735101
dose response of black american mink to aleutian mink disease virus.aleutian mink disease virus (amdv) causes a serious health problem for mink globally. the disease has no cure nor an effective vaccine and selection for tolerance using antibody titer is adopted by many mink farmers. the objective of this study was to investigate the effects of various doses of a local amdv isolate on the response of black american mink to infection with amdv.202032167659
dietary supplementation of ascophylum nodosum improved kidney function of mink challenged with aleutian mink disease virus.feed additives which can ease the negative effects of infection by the aleutian mink disease virus (amdv) are of interest to mink farmers. the effects of kelp meal (ascophylum nodosum) supplementation on immune response, virus replication and blood parameters of mink inoculated with amdv were assessed. amdv-free black mink (n = 75) were intranasally inoculated with a local strain of amdv and fed a commercial pellet supplemented with kelp meal at the rates of 1.5% or 0.75% of the feed or were kep ...202033256708
aleutian mink disease: spatio-temporal variation of prevalence and influence on the feral american mink.pathogens are one of the factors driving wildlife population dynamics. the spread of pathogens in wildlife is currently highly related to the transmission of pathogens from farmed animals, which has increased with the constant development of farming. here, we analysed the spatio-temporal variation in the prevalence of aleutian mink disease virus (amdv) antibodies in feral american mink (neovison vison) populations in poland (1,153 individuals from nine sites) in relation to mink farming intensit ...202033197283
ecology and infection dynamics of multi-host amdoparvoviral and protoparvoviral carnivore pathogens.amdoparvovirus and protoparvovirus are monophyletic viral genera that infect carnivores. we performed surveillance for and sequence analyses of parvoviruses in mustelids in insular british columbia to investigate parvoviral maintenance and cross-species transmission among wildlife. overall, 19.1% (49/256) of the tested animals were parvovirus-positive. aleutian mink disease virus (amdv) was more prevalent in mink (41.6%, 32/77) than martens (3.1%, 4/130), feline panleukopenia virus (fpv) was mor ...202032075256
detection, genetic, and codon usage bias analyses of the vp2 gene of mink bocavirus.mink bocavirus 1 (mibov1), a novel virus detected from the feces of domestic minks in china in 2016, may be related to gastrointestinal diseases. however, its prevalence and genetic characteristics are poorly described. in this study, we examined 192 samples collected from minks in the major mink industry province from northern china. pcr results showed that 10 samples (5.2%) were positive for mibov1, and 60% of mibov1-positive samples were co-infected with aleutian mink disease virus or mink ci ...202032020392
aptamer-targeting of aleutian mink disease virus (amdv) can be an effective strategy to inhibit virus replication.aleutian mink disease (amd), which is caused by aleutian mink disease virus (amdv), is an important contagious disease for which no effective vaccine is yet available. amd causes major economic losses for mink farmers globally and threatens some carnivores such as skunks, genets, foxes and raccoons. aptamers have exciting potential for the diagnosis and/or treatment of infectious viral diseases, including amd. using a magnetic beads-based systemic evolution of ligands by exponential enrichment ( ...202133633317
lesions associated with bartonella taylorii-like bacterium infection in a free-ranging, young-of-the-year raccoon from prince edward island, canada.a young-of-the year, female raccoon was presented with clinical signs of weakness and tremors. the raccoon was euthanized, and autopsy findings included poor body condition, diffuse lymphadenopathy, and pale, firm kidneys with petechial hemorrhages throughout the renal cortex. histologic lesions included systemic fibrinoid vascular necrosis and severe renal lesions, including lymphoplasmacytic interstitial nephritis and fibrinosuppurative glomerulonephritis. inflammatory vascular lesions were al ...202133463406
effects of health related farm-level factors on skin size and quality in commercial mink (neovison vison) production.this study investigated the potential effects of management and health related factors on the productivity in the commercial mink production, during 2015-2018. data were available from the database at kopenhagen fur, the national veterinary prescription database, vetstat, and the laboratory database at the center for diagnostics, technological university of denmark. a cross-sectional study, including 1.464 min. farms grouped into 1.187 epidemiological units, was applied. data were analyzed in tw ...202134058689
detection of selection signatures for response to aleutian mink disease virus infection in american mink.aleutian disease (ad) is the most significant health issue for farmed american mink. the objective of this study was to identify the genomic regions subjected to selection for response to infection with aleutian mink disease virus (amdv) in american mink using genotyping by sequencing (gbs) data. a total of 225 black mink were inoculated with amdv and genotyped using a gbs assay based on the sequencing of apeki-digested libraries. five ad-characterized phenotypes were used to assign animals to p ...202133536540
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