Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| aptamer-targeting of aleutian mink disease virus (amdv) can be an effective strategy to inhibit virus replication. | aleutian mink disease (amd), which is caused by aleutian mink disease virus (amdv), is an important contagious disease for which no effective vaccine is yet available. amd causes major economic losses for mink farmers globally and threatens some carnivores such as skunks, genets, foxes and raccoons. aptamers have exciting potential for the diagnosis and/or treatment of infectious viral diseases, including amd. using a magnetic beads-based systemic evolution of ligands by exponential enrichment ( ... | 2021 | 33633317 |
| detection of selection signatures for response to aleutian mink disease virus infection in american mink. | aleutian disease (ad) is the most significant health issue for farmed american mink. the objective of this study was to identify the genomic regions subjected to selection for response to infection with aleutian mink disease virus (amdv) in american mink using genotyping by sequencing (gbs) data. a total of 225 black mink were inoculated with amdv and genotyped using a gbs assay based on the sequencing of apeki-digested libraries. five ad-characterized phenotypes were used to assign animals to p ... | 2021 | 33536540 |
| lesions associated with bartonella taylorii-like bacterium infection in a free-ranging, young-of-the-year raccoon from prince edward island, canada. | a young-of-the year, female raccoon was presented with clinical signs of weakness and tremors. the raccoon was euthanized, and autopsy findings included poor body condition, diffuse lymphadenopathy, and pale, firm kidneys with petechial hemorrhages throughout the renal cortex. histologic lesions included systemic fibrinoid vascular necrosis and severe renal lesions, including lymphoplasmacytic interstitial nephritis and fibrinosuppurative glomerulonephritis. inflammatory vascular lesions were al ... | 2021 | 33463406 |
| effects of health related farm-level factors on skin size and quality in commercial mink (neovison vison) production. | this study investigated the potential effects of management and health related factors on the productivity in the commercial mink production, during 2015-2018. data were available from the database at kopenhagen fur, the national veterinary prescription database, vetstat, and the laboratory database at the center for diagnostics, technological university of denmark. a cross-sectional study, including 1.464 min. farms grouped into 1.187 epidemiological units, was applied. data were analyzed in tw ... | 2021 | 34058689 |
| aleutian mink disease: spatio-temporal variation of prevalence and influence on the feral american mink. | pathogens are one of the factors driving wildlife population dynamics. the spread of pathogens in wildlife is currently highly related to the transmission of pathogens from farmed animals, which has increased with the constant development of farming. here, we analysed the spatio-temporal variation in the prevalence of aleutian mink disease virus (amdv) antibodies in feral american mink (neovison vison) populations in poland (1,153 individuals from nine sites) in relation to mink farming intensit ... | 2020 | 33197283 |
| ecology and infection dynamics of multi-host amdoparvoviral and protoparvoviral carnivore pathogens. | amdoparvovirus and protoparvovirus are monophyletic viral genera that infect carnivores. we performed surveillance for and sequence analyses of parvoviruses in mustelids in insular british columbia to investigate parvoviral maintenance and cross-species transmission among wildlife. overall, 19.1% (49/256) of the tested animals were parvovirus-positive. aleutian mink disease virus (amdv) was more prevalent in mink (41.6%, 32/77) than martens (3.1%, 4/130), feline panleukopenia virus (fpv) was mor ... | 2020 | 32075256 |
| detection, genetic, and codon usage bias analyses of the vp2 gene of mink bocavirus. | mink bocavirus 1 (mibov1), a novel virus detected from the feces of domestic minks in china in 2016, may be related to gastrointestinal diseases. however, its prevalence and genetic characteristics are poorly described. in this study, we examined 192 samples collected from minks in the major mink industry province from northern china. pcr results showed that 10 samples (5.2%) were positive for mibov1, and 60% of mibov1-positive samples were co-infected with aleutian mink disease virus or mink ci ... | 2020 | 32020392 |
| dietary supplementation of ascophylum nodosum improved kidney function of mink challenged with aleutian mink disease virus. | feed additives which can ease the negative effects of infection by the aleutian mink disease virus (amdv) are of interest to mink farmers. the effects of kelp meal (ascophylum nodosum) supplementation on immune response, virus replication and blood parameters of mink inoculated with amdv were assessed. amdv-free black mink (n = 75) were intranasally inoculated with a local strain of amdv and fed a commercial pellet supplemented with kelp meal at the rates of 1.5% or 0.75% of the feed or were kep ... | 2020 | 33256708 |
| dose response of black american mink to aleutian mink disease virus. | aleutian mink disease virus (amdv) causes a serious health problem for mink globally. the disease has no cure nor an effective vaccine and selection for tolerance using antibody titer is adopted by many mink farmers. the objective of this study was to investigate the effects of various doses of a local amdv isolate on the response of black american mink to infection with amdv. | 2020 | 32167659 |
| molecular epidemiology of aleutian mink disease virus causing outbreaks in mink farms from southwestern europe: a retrospective study from 2012 to 2019. | aleutian mink disease virus (amdv) causes major economic losses in fur-bearing animal production. the control of most amdv outbreaks is complex due to the difficulties of establishing the source of infection based only on the available on-farm epidemiological data. in this sense, phylogenetic analysis of the strains present in a farm may help elucidate the origin of the infection and improve the control and biosecurity measures. | 2020 | 32735101 |
| a comparison between intraperitoneal injection and intranasal and oral inoculation of mink with aleutian mink disease virus. | intranasal, with (ins) and without (in) sedation, and oral inoculation were compared with intraperitoneal (ip) injection for establishing infection with a local isolate of aleutian mink disease virus (amdv) in 35 american mink. blood samples were collected on 0, 21, 36 and 56 day post-inoculation (dpi). antiviral-antibodies and viral dna in plasma and tissues were measured by counter-immunoelectrophoresis (ciep) and pcr, respectively. the presence of amdv dna was tested by pcr in saliva, rectal ... | 2019 | 30856435 |
| development and evaluation of a direct taqman qpcr assay for the rapid detection of diverse carnivore amdoparvoviruses. | amdoparvoviruses infect carnivore species, including mink, raccoon dog, fox, skunk, and red panda. amdoparvovirus infection is a major cause of morbidity and mortality in farmed minks. here, we developed a direct taqman qpcr assay for detection and quantification of carnivore amdoparvoviruses by using three primers and one probe based on the conserved vp2 gene. the detection limit for aleutian mink disease virus (amdv) and raccoon dog and arctic fox amdoparvovirus (rfav) were 4.06 × 101 copies/μ ... | 2019 | 31521579 |
| endemic skunk amdoparvovirus in free-ranging striped skunks (mephitis mephitis) in california. | the genus amdoparvovirus includes the newly discovered skunk amdoparvovirus and the well-characterized aleutian disease virus which causes significant health impacts in farmed mink worldwide. in 2010-2013, an outbreak of fatal amdoparvovirus-associated disease was documented in free-ranging striped skunks (mephitis mephitis) from the san francisco bay area of california. to characterize the geographic distribution, earliest occurrence and abundance of this virus, as well as possible impacts on s ... | 2019 | 31206251 |
| amdoparvovirus infection in red pandas ( ailurus fulgens). | aleutian mink disease virus is the type species in the genus amdoparvovirus, and in mink and other mustelidae can cause either subclinical disease or fatal chronic immune stimulation and immune complex disease. the authors describe a novel amdoparvovirus in the endangered red panda ( ailurus fulgens), discovered using viral metagenomics. the authors analyzed the prevalence, tissue distribution, and disease association by pcr, in situ hybridization, electron microscopy, and histology in a group o ... | 2018 | 29433401 |
| the use of phoxim and bendiocarb for control of fleas in farmed mink (mustela vison). | fleas (ceratophyllus sciurorum) are common on farmed mink in denmark. when present, the fleas have a negative impact on the health of the farmed mink and are of nuisance for farm staff. severe infestations of fleas cause anemia, poor growth and may result in death of mink kits. changed behavior of the dams is also observed. further it has been demonstrated that the fleas are vectors of aleutian disease virus. flea control is based on use of a few insecticides and resistance has been reported aga ... | 2018 | 30243298 |
| distribution of aleutian mink disease virus contamination in the environment of infected mink farms. | control and eradication of aleutian mink disease virus (amdv) are a major concern for fur-bearing animal production. despite notably reducing disease prevalence, current control programs are unable to prevent the reinfection of farms, and environmental amdv persistence seems to play a major role regarding this issue. in this study 114 samples from different areas and elements of seven infected mink farms were analyzed by qpcr in order to evaluate the environmental distribution of amdv load. samp ... | 2017 | 28532807 |
| full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (mephitis mephitis). | amdoparvovirus is a newly defined parvoviral genus that contains four species (carnivore amdoparvovirus 1-4), including the well-known aleutian mink disease virus (amdv). amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in mustelidae and caninae hosts. in this study, we molecularly investigated amdoparvoviruses detected in 44 striped skunks (mephitis mephitis) found dead in and around vancouver, british columbia, canada. some of the animals exhibited pathological cha ... | 2017 | 28487558 |
| construction and immunogenicity analysis of whole-gene mutation dna vaccine of aleutian mink virus isolated virulent strain. | aleutian mink disease (ad) is a chronic viral infection that causes autoimmune disorders in minks and presents a significant economic burden on mink farming. despite the substantial challenges presented by ad, no effective vaccine is available and only partial protection has been achieved. we constructed a whole-gene nucleic acid vaccine from an isolated virulent aleutian mink disease virus (adv) strain (pcdna3.1-adv). based on this whole-gene nucleic acid vaccine, we generated truncated mutant ... | 2017 | 28829241 |
| aleutian disease virus-like virus ( amdoparvovirus sp.) infecting free-ranging striped skunks (mephitis mephitis) in the midwestern united states. | aleutian disease virus (adv) and closely related (adv-like) viruses are parvoviridae members (genus amdoparvovirus) that primarily infect farmed mustelids and have been detected in humans and free-ranging carnivora from north america. we describe adv-like/ amdoparvovirus sp. infection in four free-ranging striped skunks (mephitis mephitis) from the midwestern united states. | 2017 | 28820299 |
| outbreak tracking of aleutian mink disease virus (amdv) using partial ns1 gene sequencing. | aleutian mink disease (amd) is an infectious disease of mink (neovison vison) and globally a major cause of economic losses in mink farming. the disease is caused by aleutian mink disease virus (amdv) that belongs to the genus amdoparvovirus within the parvoviridae family. several strains have been described with varying virulence and the severity of infection also depends on the host's genotype and immune status. clinical signs include respiratory distress in kits and unthriftiness and low qual ... | 2017 | 28637462 |
| a fast and accurate method of detecting aleutian mink disease virus in blood and tissues of chronically infected mink. | the objective of this study was to assess the sensitivity of the omni klentaq-la dna polymerase for detecting aleutian mink disease virus (amdv) in mink blood and tissues by pcr without dna extraction. the presence of amdv dna was directly tested by klentaq in the plasma, serum, whole blood, and spleen homogenates of 188 mink 4 and 16 months after inoculation with the virus. samples from bone marrow, small intestine, liver, lungs, kidneys, and lymph nodes of 20 of the same mink were also tested ... | 2017 | 28177788 |
| high molecular polymorphism of the hypervariable region in the vp2 gene of aleutian mink disease virus. | parvoviruses exhibit extreme genetic plasticity. the vp2 protein, containing a hypervariable region, is of particular importance. a single nucleotide change in this part of the genome and its effect on the amino acid sequence may significantly affect the range of infected hosts, tropism for specific tissues, or virulence. the high polymorphism in the hypervariable region can be exploited for phylogenetic analysis. the aim of this study was to analyze the polymorphism of the vp2 hypervariable reg ... | 2017 | 27928914 |
| reduced severity of histopathological lesions in mink selected for tolerance to aleutian mink disease virus infection. | the objective of this study was to measure the effect of selection for tolerance on the severity of the aleutian disease (ad) lesions in mink. sensitivity and specificity of antibody detection in the blood by counter-immunoelectrophoresis (ciep) relative to the presence of aleutian mink disease virus (amdv) in the spleen by pcr in naturally infected farmed mink were also estimated. carcasses of 680 sero-positive (ciep-p) black mink from 28 farms in nova scotia, canada, and from 132 sero-negative ... | 2017 | 28249174 |
| serology and protein electrophoresis for evidence of exposure to 12 mink pathogens in free-ranging american mink (neovison vison) in argentina. | basic pathologic characteristics for farmed minks were previously reported worldwide. however, its status in the wild has not been studied in detail. | 2017 | 28635524 |
| beyond rabies: are free-ranging skunks (mephitis mephitis) in british columbia reservoirs of emerging infection? | wild animal reservoirs are an important source of emerging and zoonotic infection. skunks (mephitis mephitis) are a reservoir of skunk strain rabies virus in canada, with the exception of some areas including the province of british columbia (bc). beyond rabies, the reservoir status of skunks for emerging and zoonotic pathogens in bc is unknown. from march 2011 to february 2015, 50 free-ranging skunks were necropsied and tested for 4 pathogens: influenza a, aleutian disease virus (adv), leptospi ... | 2017 | 26392297 |
| evolutionary analysis of whole-genome sequences confirms inter-farm transmission of aleutian mink disease virus. | aleutian mink disease virus (amdv) is a frequently encountered pathogen associated with mink farming. previous phylogenetic analyses of amdv have been based on shorter and more conserved parts of the genome, e.g. the partial ns1 gene. such fragments are suitable for detection but are less useful for elucidating transmission pathways while sequencing entire viral genomes provides additional informative sites and often results in better-resolved phylogenies. we explore how whole-genome sequencing ... | 2017 | 28612703 |
| prevalence of antibody to aleutian mink disease virus in european mink (mustela lutreola) and american mink (neovison vison) in spain. | the european mink (mustela lutreola) has undergone a dramatic decline and is one of the most endangered mammals in the world. the invasive american mink (neovison vison) is considered the main factor for this decline. however, the american mink's introduction and the subsequent ecological concurrence of the two species cannot solely explain the decline or disappearance of the european mink. aleutian mink disease virus (amdv) is the main health problem in fur farming worldwide, causing varied cli ... | 2016 | 26528576 |
| development of a peptide elisa for the diagnosis of aleutian mink disease. | aleutian disease (ad) is a common immunosuppressive disease in mink farms world-wide. since the 1980s, counterimmunoelectrophoresis (ciep) has been the main detection method for infection with the aleutian mink disease virus (amdv). in this study, six peptides derived from the amdv structural protein vp2 were designed, synthesized, and used as elisa antigens to detect anti-amdv antibodies in the sera of infected minks. serum samples were collected from 764 minks in farms from five different prov ... | 2016 | 27802320 |
| driving forces behind the evolution of the aleutian mink disease parvovirus in the context of intensive farming. | aleutian mink disease virus (amdv) causes plasmacytosis, an immune complex-associated syndrome that affects wild and farmed mink. the virus can also infect other small mammals (e.g., ferrets, skunks, ermines, and raccoons), but the disease in these hosts has been studied less. in 2007, a mink plasmacytosis outbreak began on the island of newfoundland, and the virus has been endemic in farms since then. in this study, we evaluated the molecular epidemiology of amdv in farmed and wild animals of n ... | 2016 | 27774297 |
| identification of a novel aleutian mink disease virus b-cell epitope using a monoclonal antibody against vp2 protein. | aleutian mink disease virus (amdv) is a parvovirus that causes an immune complex-mediated disease in minks. capsid protein vp2 is a major structural viral protein and can be used to diagnose amdv. in this study, a specific monoclonal antibody, 1m13, was produced against the amdv vp2 protein (amino acids 291-502). a linear vp2-protein epitope was identified by subjecting a series of partially overlapping synthesized peptides to be enzyme-linked immunosorbent assay (elisa) analysis. the results in ... | 2016 | 27354304 |
| accuracy of enzyme-linked immunosorbent assays for quantification of antibodies against aleutian mink disease virus. | there is a growing interest among mink ranchers to select their stock for tolerance to the aleutian mink disease virus (amdv). enzyme-linked immunosorbent assays (elisa) are used to identify mink which have low anti-amdv antibody titres and are expected to tolerate the amdv infection. the objective of this study was to calculate the accuracy of three elisa systems which were performed on blood or serum of amdv-inoculated american mink (neovison vison) at five laboratories in canada, usa, finland ... | 2016 | 27283885 |
| progression of experimental chronic aleutian mink disease virus infection. | aleutian mink disease virus (amdv) is found world-wide and has a major impact on mink health and welfare by decreasing reproduction and fur quality. in the majority of mink, the infection is subclinical and the diagnosis must be confirmed by serology or polymerase chain reaction (pcr). increased knowledge based on a systematically description of clinical signs, pathology and histopathology might be a tool to reduce the risk of infection from subclinically infected mink to amdv free herds. the ai ... | 2016 | 27250118 |
| a fast and robust method for whole genome sequencing of the aleutian mink disease virus (amdv) genome. | aleutian mink disease virus (amdv) is a frequently encountered pathogen associated with commercial mink breeding. amdv infection leads to increased mortality and compromised animal health and welfare. currently little is known about the molecular evolution of the virus, and the few existing studies have focused on limited regions of the viral genome. this paper describes a robust, reliable, and fast protocol for amplification of the full amdv genome using long-range pcr. the method was used to g ... | 2016 | 27060623 |
| development of an enzyme-linked immunosorbent assay based on fusion vp2332-452 antigen for detecting antibodies against aleutian mink disease virus. | for detection of aleutian mink disease virus (amdv) antibodies, an enzyme-linked immunosorbent assay (elisa) was developed using the recombinant vp2332-452 protein as an antigen. counterimmunoelectrophoresis (ciep) was used as a reference test to compare the results of the elisa and western blotting (wb); the specificity and sensitivity of the vp2332-452 elisa were 97.9% and 97.3%, respectively, which were higher than those of wb. therefore, this vp2332-452 elisa may be a preferable method for d ... | 2016 | 26582828 |
| genetic characterization of the complete genome of an aleutian mink disease virus isolated in north china. | the genome of a highly pathogenic strain of aleutian disease mink virus (amdv-bj) isolated from a domestic farm in north china has been determined and compared with other strains. alignment analysis of the major structural protein vp2 revealed that amdv-bj is unique among 17 other amdv strains. compared with the nonpathogenic strain adv-g, the 3' end y-shaped hairpin was highly conserved, while a 4-base deletion in the 5' u-shaped terminal palindrome resulted in a different unpaired "bubble" gro ... | 2016 | 27007772 |
| corrigendum: amdoparvoviruses in small mammals: expanding our understanding of parvovirus diversity, distribution, and pathology. | [this corrects the article on p. 1119 in vol. 6, pmid: 26528267.]. | 2016 | 26973636 |
| [sequencing analyses of the hypervariable region within the vp2 gene of a strain of the aleutian mink disease virus]. | to analyze the molecular mechanisms of cross-host transmission of the aleutian mink disease vi rus (adv), the hypervariable region fragment of the vp2 gene of the adv in jilin province (china) was amplified. sequencing analyses showed diversity at residue 174 by comparison with other vp2 genes in genbank. the phylogenetic tree indicated that the adv-jl strain had a close relationship with the highly pathogenic strain from denmark: adv-k. results implied that residue 174 may be associated with ad ... | 2015 | 26470526 |
| detection of aleutian disease virus by loop-mediated isothermal amplification. | in this study, a loop-mediated isothermal amplification (lamp) assay was developed and optimized for the detection of aleutian disease virus (adv) in minks. the amplification could be completed within 45 min under isothermal condition by employing a set of six adv genome-specific primers. the amplification results could be visualized directly with the naked eye by using fluorescent dye. comparative experiments showed that the lamp assay is superior to conventional polymerase chain reaction for t ... | 2015 | 26396989 |
| molecular epidemiology of aleutian mink disease virus (amdv) in estonia, and a global phylogeny of amdv. | aleutian mink disease virus (amdv) causes a severe disease called aleutian disease (ad). amdv infects primarily mustelids, but also other mammal species. recent evidence suggests that amdv may also affect humans. to examine amdv in different wild animals and in farmed mink in estonia, we collected 203 blood samples from eight mammal species in 2007-2010, of which 152 were from species living in the wild (american mink, european mink, pine marten, polecat, raccoon dog, badger, otter, and stone ma ... | 2015 | 25616049 |
| development of a nanoparticle-assisted pcr (nanopcr) assay for detection of mink enteritis virus (mev) and genetic characterization of the ns1 gene in four chinese mev strains. | mink enteritis virus (mev) causes mink viral enteritis, an acute and highly contagious disease whose symptoms include violent diarrhea, and which is characterized by high morbidity and mortality. nanoparticle-assisted polymerase chain reaction (nanopcr) is a recently developed technique for the rapid detection of bacterial and viral dna. here we describe a novel nanopcr assay for the clinical detection and epidemiological characterization of mev. | 2015 | 25582057 |
| aleutian disease: an emerging disease in free-ranging striped skunks (mephitis mephitis) from california. | aleutian disease virus (adv, amdovirus, parvoviridae) primarily infects farmed mustelids (mink and ferrets) but also other fur-bearing animals and humans. three aleutian disease (ad) cases have been described in captive striped skunks; however, little is known about the relevance of ad in free-ranging carnivores. this work describes the pathological findings and temporospatial distribution in 7 cases of ad in free-ranging striped skunks. all cases showed neurologic disease and were found in a 46 ... | 2015 | 25445322 |
| [research into the antibody detection technology of mink plasmacytosis and its current applications]. | mink plasmacytosis, caused by aleutian mink disease virus (amdv), poses a threat to the development of the animal fur industry. neutralizing antibodies against amdv may result in a persistent infection rather than providing protection for minks. to date,no specific methods to prevent or cure this disease have been developed. in order to eliminate mink plasmacytosis, antibody detection technology has been used globally as a dominant approach to screen for amdv-positive minks. this paper introduce ... | 2015 | 25997336 |
| detection of aleutian mink disease virus dna and antiviral antibodies in american mink (neovison vison) 10 days postinoculation. | early detection of infection by the aleutian mink disease virus (amdv; carnivore amdoparvovirus 1) by polymerase chain reaction (pcr) or counterimmunoelectrophoresis (ciep) has important ramifications in virus eradication programs. a spleen homogenate containing a local isolate of amdv was injected intraperitoneally into black (n = 44) and sapphire (n = 12) american mink (neovison vison). animals were euthanized 10 days postinoculation and anti-amdv antibodies and amdv dna were tested in plasma ... | 2015 | 25862712 |
| aleutian mink disease virus in free-ranging mink from sweden. | aleutian mink disease (amd) is a chronic viral disease in farmed mink and the virus (amdv) has been found in many free-ranging mink (neovison vison) populations in europe and north america. in this study, amdv dna and amdv antibodies were analysed in 144 free-ranging mink hunted in sweden. associations between being amdv infected (defined as positive for both viral dna and antibodies) and the weight of the spleen, liver, kidneys, adrenal glands and body condition were calculated and the sequence ... | 2015 | 25822750 |
| aleutian mink disease virus in free-ranging mustelids in finland - a cross-sectional epidemiological and phylogenetic study. | aleutian mink disease virus (amdv) can cause severe immune-complex-mediated disease in american mink. amdv has also been detected in several other mustelid species with potential negative impact on their health and population. a molecular and cross-sectional epidemiological study was conducted to obtain data on the prevalence, distribution, transmission and diversity of amdv strains in finnish free-ranging mustelids and risk factors associated with infection. the presence of anti-amdv antibodies ... | 2015 | 25667324 |
| aleutian mink disease virus in striped skunks (mephitis mephitis): evidence for cross-species spillover. | aleutian mink disease virus (amdv) causes a parvovirus infection, initially characterized in american mink (neovison vison), that may have harmful effects on wild populations of susceptible animals. in north america, where american mink are native, the origin, host range, and prevalence of amdv in wild species is not clear. we studied striped skunks (mephitis mephitis) and raccoons (procyon lotor) to determine whether species sympatric with mink are potential reservoirs in the transmission of am ... | 2015 | 25647590 |
| amdoparvoviruses in small mammals: expanding our understanding of parvovirus diversity, distribution, and pathology. | many new viruses have been discovered recently, thanks in part to the advent of next-generation sequencing technologies. among the parvoviridae, three novel members of the genus amdoparvovirus have been described in the last 4 years, expanding this genus that had contained a single species since its discovery, aleutian mink disease virus. the increasing number of molecular and epidemiological studies on these viruses around the world also highlights the growing interest in this genus. some aspec ... | 2015 | 26528267 |
| diagnosing aleutian mink disease infection by a new fully automated elisa or by counter current immunoelectrophoresis: a comparison of sensitivity and specificity. | aleutian disease (ad) is a severe disease characterized by hypergammaglobulinemia causing multiple symptoms such as acute renal failure, arteritis, reduced reproductive performance and pneumonia in mink. ad is caused by the parvovirus aleutian mink disease virus (adv) and diagnosed primarily based on adv serology sometimes supplemented by organ pcr analysis. in denmark, approximately 3.5-4 million serum samples are tested every year for the presence of anti adv antibodies as part of a national e ... | 2014 | 24462658 |
| molecular characterization of the small nonstructural proteins of parvovirus aleutian mink disease virus (amdv) during infection. | aleutian mink disease virus (amdv) is the only member in genus amdovirus of the family parvoviridae. during amdv infection, six species of viral transcripts are generated from one precursor mrna through alternative splicing and alternative polyadenylation. in addition to the large non-structural protein ns1, two small non-structural proteins, ns2 and ns3, are putatively encoded (qiu j, et al., 2006. j. virol. 80 654-662). however, these two proteins have not been experimentally demonstrated duri ... | 2014 | 24606679 |
| molecular epidemiology of aleutian mink disease virus in china. | aleutian mink disease (mink plasmacytosis) is a very severe immune-complex-mediated disease affecting minks. it is caused by the aleutian mink disease virus (amdv). to obtain a better understanding of the molecular epidemiology of amdv in china, a total of 420 samples were collected from mink farms in five major mink-farming provinces in china. after testing serum antibodies using counterimmunoelectrophoresis (ciep), 23 of the 340 positive samples were randomly selected and analyzed. the full le ... | 2014 | 24561116 |
| [eenie, meenie, miney, moe, who is responsible for the antibody-dependent enhancement of aleutian mink disease parvovirus infection?]. | aleutian mink disease parvovirus (amdv) causes a persistent infection associated with immune complex disease, hypergammaglobulinemia, and high levels of antiviral antibodies. despite the presence of an antibody, the virus is not cleared in vivo. pre-existing antibodies may enhance viral infections, by fc-receptor-mediated antibody-dependent enhancement (ade), but the mechanism that underlies ade has not been fully defined. three models have been proposed, including: (1) interactions between anti ... | 2014 | 25272602 |
| application of real-time pcr to detect aleutian mink disease virus on environmental farm sources. | the aleutian mink virus (amdv) causes the aleutian mink disease (amd) or mink plasmacytosis, a disease responsible of high economic losses for industry worldwide. despite there is evidence of the environmental persistence of the virus, there is not literature on the detection of this virus in environmental samples in farms and this fact would have great importance in the control programs of the disease. in order to detect contamination caused by amdv on farms, several environmental samples were ... | 2014 | 25183237 |
| inactivation of aleutian mink disease virus through high temperature exposure in vitro and under field-based composting conditions. | disposal of manure contaminated with aleutian mink disease virus (amdv) is a significant concern to the mink industry. inactivation of amdv under field conditions has received limited attention in the scientific literature. we evaluated the thermal inactivation of amdv in vitro and during composting of mink manure. spleen homogenate containing amdv was heated under controlled conditions at 45°c, 55°c, and 65°c for 3 days. results of the in vitro study identified complete absence of viral replica ... | 2014 | 25139658 |
| validation of an automated elisa system for detection of antibodies to aleutian mink disease virus using blood samples collected in filter paper strips. | aleutian mink disease virus (amdv) is the cause of a chronic immune complex disease, aleutian disease (ad), which is common in mink-producing countries. in 2005, implementation of an amdv eradication programme in finland created a need for an automated high-throughput assay. the aim of this study was to validate an amdv-vp2 -recombinant antigen elisa, which we developed earlier, in an automated assay format for the detection of anti-amdv antibodies in mink blood and to determine the accuracy of ... | 2014 | 25103400 |
| testing for aleutian mink disease virus in the river otter (lontra canadensis) in sympatry with infected american mink (neovison vison). | aleutian mink disease virus (amdv) occurs in the american mink (neovison vison) in wild populations and on mink farms and can cause illness and death. the north american river otter (lontra canadensis) may be exposed to amdv because of shared space and habitat with mink. using serology and real-time pcr, we tested river otters across ontario for amdv infection. we found no evidence of infection in otters, a surprising finding given the sympatric distribution, niche overlap, and close phylogeneti ... | 2014 | 24807350 |
| monitoring chronic infection with a field strain of aleutian mink disease virus. | aleutian mink disease virus (amdv) readily spread within farmed mink and causes chronic infections with significant impacts for welfare and economy. in the present study a currently circulating danish amdv strain was used to induce chronic experimental infection of farmed mink. pcr was used to detect viral dna in full blood, organs, faeces and oro-nasal swabs weekly for the first 8 weeks and then biweekly for another 16 weeks after amdv challenge inoculation of wild type mink. the mink (n=29) wa ... | 2014 | 24389253 |
| evaluation of two enzyme-linked immunosorbent assays for serodiagnosis of aleutian mink disease virus infection in mink. | aleutian disease in mink is caused by infection with aleutian mink disease virus (amdv). in sweden, the infection most commonly causes classical aleutian disease in which the immune system fails to neutralize the virus and the infection becomes persistent. diagnosis of amdv infection is based on serological methods that detect virus-specific antibodies. traditionally counterimmunoelectrophoresis (ciep) has been the preferred method, but in order to enable automation interest has been paid to oth ... | 2013 | 24274663 |
| aleutian mink disease virus in furbearing mammals in nova scotia, canada. | aleutian mink disease virus (amdv) is widespread among ranched and free-ranging american mink in canada, but there is no information on its prevalence in other wild animal species. this paper describes the prevalence of amdv of 12 furbearing species in nova scotia (ns), canada. | 2013 | 23394546 |
| detection of mink enteritis virus by loop-mediated isothermal amplification (lamp). | loop-mediated isothermal amplification (lamp) method was discovered in the last decade but only used for the first time in the diagnosis of mink enteritis virus (mev) infection in this study. the amplification could be completed within 60 min, under isothermal condition at 65°c, by employing a set of four primers targeting the vp2 gene of mev. the lamp was more sensitive than the conventional pcr, with a detection limit of 10(-1) median tissue culture infective doses (tcid(50))/ml per reaction, ... | 2013 | 23183142 |
| identification of biosecurity measures and spatial variables as potential risk factors for aleutian disease in danish mink farms. | eradication of aleutian disease was initiated in denmark in 1976. the prevalence of positive farms has since then been reduced from 100% to only being continuously present in the region of vendsyssel, northern denmark since 2004. in this study, we attempted to identify risk factors for the infection in this region based on logistic regression of spatial (environmental, neighbourhood) variables and biosecurity measures. information on potential biosecurity (management) risk factors in the region ... | 2012 | 22717327 |
| high prevalence of aleutian mink disease virus in free-ranging mink on a remote danish island. | aleutian mink disease virus (amdv) causes severe disease in farmed mink (neovison vison) worldwide. in denmark, amdv in farmed mink has been confined to the northern part of the mainland since 2002. from 1998 to 2009, samples from 396 free-ranging mink were collected from mainland denmark, and a low amdv antibody prevalence (3% of 296) was found using countercurrent immune electrophoresis. however, on the island of bornholm in the baltic sea, a high prevalence (45% of 142 mink) was detected in t ... | 2012 | 22493130 |
| phylogenetic analysis of the vp2 gene of aleutian mink disease parvoviruses isolated from 2009 to 2011 in china. | aleutian mink disease parvovirus (amdv) is a non-enveloped virus with a single-stranded dna genome that causes a fatal, usually persistent immune complex disease in minks. in this study, a total of 18,654 serum samples were collected from minks that were farmed in china from 2009 to 2011. after testing by counter-current immunoelectrophoresis (cie), the seroprevalence of amdv was found to be 68.67 %. the results show that there is a serious epidemic among chinese minks used for breeding. to gain ... | 2012 | 22415542 |
| genetic characterization of aleutian mink disease viruses isolated in china. | aleutian mink disease virus (amdv) is a parvovirus that causes an immune complex mediated disease in minks. to understand the genetic characterization of amdv in china, the genomic sequences of three isolates, adv-ln1, adv-ln2, and adv-ln3, from different farms in the northern china were analyzed. the results showed that the lengths of genomic sequences of three isolates were 4,543, 4,566, and 4,566 bp, respectively. they shared only 95.5-96.3 % nucleotide identity with each other. the nucleotid ... | 2012 | 22415541 |
| internal polyadenylation of parvoviral precursor mrna limits progeny virus production. | aleutian mink disease virus (amdv) is the only virus in the genus amdovirus of family parvoviridae. in adult mink, amdv causes a persistent infection associated with severe dysfunction of the immune system. cleavage of amdv capsid proteins has been previously shown to play a role in regulating progeny virus production (fang cheng et al., j. virol. 84:2687-2696, 2010). the present study shows that amdv has evolved a second strategy to limit expression of capsid proteins by preventing processing o ... | 2012 | 22361476 |
| molecular epidemiology of aleutian disease virus in free-ranging domestic, hybrid, and wild mink. | aleutian mink disease (amd) is a prominent infectious disease in mink farms. the amd virus (amdv) has been well characterized in europe where american mink (neovison vison) are an introduced species; however, in north america, where american mink are native and the disease is thought to have originated, the virus' molecular epidemiology is unknown. as such, we characterized viral isolates from ontario free-ranging mink of domestic, hybrid, and wild origin at two proteins: ns1, a nonstructural pr ... | 2012 | 25568054 |
| prevalence of the aleutian mink disease virus infection in nova scotia, canada. | despite many years of testing mink for serum antibodies against the aleutian mink disease virus (amdv) by counterimmunoelectrophoresis (ciep) and elimination of reactors, this virus has remained the number one disease threat for the mink industry in nova scotia (ns). the objective of this study was to analyze ciep test results to determine the success of the amdv-control strategy in ns. a total of 2,964,920 ciep test results from 82 ranches, spanning an eight-year period between 1998 and 2005, w ... | 2012 | 22497690 |
| histopathologic and immunohistochemical lesions in liver of mink infected with aleutian disease virus. | parvovirus of aleutian disease causes mainly damage to kidneys, but immune complexes deposition and damage may occur also in other organs. in mink farms of latvia the liver dystrophy or hepatic lipidosis of mink is widely distributed. the goal of this study was to examine probability of liver damage and regeneration of mink infected with aleutian disease virus. liver injury was assessed histologically. the mink liver demonstrated inflammation of liver parenchyma and foci of fatty liver. in immun ... | 2011 | 21528714 |
| persistent spatial clusters of plasmacytosis among danish mink farms. | aleutian disease (plasmacytosis) is caused by the aleutian mink disease virus (amdv), an autonomous parvovirus and affects many mustelid species, including the american mink (neovisonvison). in denmark, an eradication program reduced the prevalence of test-positive farms from 100% in 1976 to 15% in 1996. nevertheless, the disease persists in the vendsyssel district of northern jutland, despite the eradication efforts. in this study, we used spatial epidemiological analysis to test for spatial au ... | 2011 | 21788091 |
| Novel amdovirus in gray foxes. | We used viral metagenomics to identify a novel parvovirus in tissues of a gray fox (Urocyon cinereoargenteus). Nearly full genome characterization and phylogenetic analyses showed this parvovirus (provisionally named gray fox amdovirus) to be distantly related to Aleutian mink disease virus, representing the second viral species in the Amdovirus genus. | 2011 | 22000359 |
| naturally occurring influenza a virus subtype h1n2 infection in a midwest united states mink (mustela vison) ranch. | influenza a virus (fluav) causes acute respiratory disease in humans and a variety of animal species. the virus tends to remain within the species of origin; nonetheless, naturally occurring cross-species transmission of fluav has been periodically documented. multiple cross-species transmissions of fluav have been reported from companion animals and captive wild animals, neither of which is historically considered as natural hosts of fluav. in the fall of 2010, mink (mustela vison) inhabiting a ... | 2011 | 22362526 |
| diversity and stability of aleutian mink disease virus during bottleneck transitions resulting from eradication in domestic mink in denmark. | aleutian mink disease (plasmacytosis) virus (amdv) in domestic mink (neovison vison) has been subject to eradication in denmark since 1976. in 2001, approximately 5% of danish mink farms were still infected and all were located in the northern part of the peninsula of jutland. in the present study a total of 274 danish isolates of amdv collected during the two seasons of 2004 and 2005 were characterized by partial sequencing of the coding region of the non-structural (ns) proteins. older amdv is ... | 2010 | 21112164 |
| a survey of aleutian mink disease virus infection of feral american mink in nova scotia. | spleen samples from 14 mink that were trapped in 4 counties of nova scotia were tested for the presence of the aleutian mink disease virus (amdv) by polymerase chain reaction. viral dna was not detected in samples from kings county (n = 2), but was detected in all the mink sampled from colchester (n = 2) and halifax (n = 6) counties, and 3 of 4 mink from yarmouth county. the high level of amdv-infected mink in colchester and halifax counties may pose a serious threat to the captive mink and wild ... | 2010 | 20357945 |
| neuropathologic features of aleutian disease in farmed mink in ireland and molecular characterization of aleutian mink disease virus detected in brain tissues. | a neuropathologic survey was conducted on mink brains from the 5 licensed mink farms in ireland. the survey was part of a transmissible spongiform encephalopathy surveillance study. aleutian disease (ad) was present on 4 of the 5 farms (80%). neuropathologic features of nonsuppurative meningoencephalitis were common in mink from the 4 affected farms but were absent in the mink from the fifth farm, which was free of ad. the meningoencephalitis was characterized by infiltrates of lymphocytes and p ... | 2010 | 20093694 |
| the capsid proteins of aleutian mink disease virus activate caspases and are specifically cleaved during infection. | aleutian mink disease virus (amdv) is currently the only known member of the genus amdovirus in the family parvoviridae. it is the etiological agent of aleutian disease of mink. we have previously shown that a small protein with a molecular mass of approximately 26 kda was present during amdv infection and following transfection of capsid expression constructs (j. qiu, f. cheng, l. r. burger, and d. pintel, j. virol. 80:654-662, 2006). in this study, we report that the capsid proteins were speci ... | 2010 | 20042496 |
| implementation and validation of a sensitive pcr detection method in the eradication campaign against aleutian mink disease virus. | aleutian mink disease virus (amdv) is a severe progressive disease causing multiple different clinical syndromes in mink. in denmark, the disease is notifiable and under official control. the control programme, based on serological screening, has confined successfully amdv to the northern part of denmark. however, re-infections and new introductions of virus into farms require a confirmatory virological test to verify the positive test results of single animals and ultimately to investigate dise ... | 2010 | 20951744 |
| development and evaluation of an enzyme-linked immunosorbent assay based on recombinant vp2 capsids for the detection of antibodies to aleutian mink disease virus. | aleutian disease (ad), a common infectious disease in farmed minks worldwide, is caused by aleutian mink disease virus (amdv). serodiagnosis of ad in minks has been based on detection of amdv antibodies by counterimmunoelectrophoresis (cie) since the 1980s. the aim of this study was to develop and evaluate an enzyme-linked immunosorbent assay (elisa) based on recombinant virus-like particles (vlps) for identifying amdv antibodies from mink sera. amdv capsid protein (vp2) of a finnish wild-type s ... | 2009 | 19641102 |
| molecular epidemiology of aleutian mink disease virus in finland. | aleutian mink disease virus (amdv) is a parvovirus that causes an immune complex-mediated disease in minks. to gain a more detailed view of the molecular epidemiology of mink amdv in finland, we phylogenetically analysed 14 new finnish strains from 5 farms and all 40 strains with corresponding sequences available in genbank. a part of the major non-structural (ns1) protein gene was amplified and analysed phylogenetically. a rooted nucleotide tree was constructed using the maximum parsimony metho ... | 2009 | 18799272 |
| aleutian mink disease virus and humans. | reports of a possible relationship between aleutian mink disease parvovirus (amdv) and human infection are rare. however, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with aleutian disease were found to have amdv-specific antibodies and amdv dna. these findings raise the suspicion that amdv may play a role in human disease. | 2009 | 19961696 |
| aleutian disease serology, protein electrophoresis, and pathology of the european mink (mustela lutreola) from navarra, spain. | the european mink, mustela lutreola, has suffered a dramatic decline in europe during the 20th century and is one of the most endangered carnivores in the world. the subpopulation of european mink from navarra, spain, estimated to number approximately 420, represents approximately two thirds of the total number of mink in spain. aleutian disease virus (adv) is a parvovirus with a high degree of variability that can infect a broad range of mustelid hosts. the pathogenesis of this virus in small c ... | 2008 | 18816991 |
| infection with aleutian disease virus-like virus in a captive striped skunk. | a 5-month-old captive female striped skunk (mephitis mephitis) was evaluated because of lethargy, signs of depression, azotemia, and erythema of the skin around the eyes. | 2008 | 18312184 |
| the abundant r2 mrna generated by aleutian mink disease parvovirus is tricistronic, encoding ns2, vp1, and vp2. | the abundant r2 mrna encoded by the single left-end promoter of aleutian mink disease parvovirus is tricistronic; it not only expresses the capsid proteins vp1 and vp2 but is also the major source for the nonstructural protein ns2. a cis-acting sequence within the ns2 gene was shown to be required for efficient capsid protein production, and its effect displayed a distinct location dependence. ribosome transit through the upstream ns2 gene region was necessary for efficient vp1 and vp2 expressio ... | 2007 | 17428872 |
| [genetic analysis of aleutian mink disease virus isolated in the primorye territory]. | the nucleotide sequence of the vp2 gene for aleutian mink disease virus isolated in the fur farms in the primorye territory (russia) was determined. the isolated strain was shown to be genetically close to highly pathogenetic american strains of the utah group. an intraspecific classification of adv is proposed. | 2007 | 17601051 |
| aleutian disease in two domestic striped skunks (mephitis mephitis). | this report describes the use of polymerase chain reaction and dna in situ hybridization to diagnose aleutian mink disease parvovirus dna in various tissue specimens from 2 companion striped skunks. clinical, laboratory, and microscopic findings also support a clinical diagnosis of aleutian disease in these mink. | 2007 | 17846242 |
| [prokaryotic expression and detective application of the main antigenic region of vp2 protein of aleutian mink disease parvovirus]. | to research safer diagnosis antigen for adv, the main antigenic region vp2a and vp2b gene of adv were obtained by restriction digestion of the recombinant plasmids pmd-vp2a and pmd-vp2b. then the genes were respectively cloned into pmal-c2 to get two prokaryotic recombinant plasmids pmal-vpa and pmal-vpb. the target genes were successfully expressed in the host cell tb1 when induced by iptg. the western blot analysis proved the recombinant proteins have good antigenic. the recombinant proteins w ... | 2007 | 18271270 |
| the transcription profile of aleutian mink disease virus in crfk cells is generated by alternative processing of pre-mrnas produced from a single promoter. | a reevaluation of the transcription profile of aleutian mink disease parvovirus (amdv)-infected crfk cells at either 32 degrees c or 37 degrees c has determined that strain amdv-g encodes six species of mrnas produced by alternative splicing and alternative polyadenylation of a pre-mrna generated by a single promoter at the left end of the genome. three different splicing patterns are used, and each type is found polyadenylated at either the 3' end of the genome (the distal site) or at a site in ... | 2006 | 16378968 |
| persistent viral shedding during asymptomatic aleutian mink disease parvoviral infection in a ferret. | a 2-year-old domestic ferret that appeared clinically healthy was repeatedly seropositive for aleutian mink disease parvovirus (adv) over a 2-year observation period. antibody titers, determined by counter-immunoelectrophoresis, ranged from 1024 to 4096. viral dna also was identified in serum, urine, feces, and blood cell fractions by polymerase chain reaction analysis. ultimately, dna in situ hybridization revealed adv dna in histologic sections of various tissues and organs. these data indicat ... | 2005 | 16475522 |
| dna vaccination with the aleutian mink disease virus ns1 gene confers partial protection against disease. | aleutian disease virus (adv) causes severe losses in mink. this happens in nature as well as in farms. in spite of several attempts to provide an efficient protective protein based vaccine, experiments have failed so far. only partial protection has been obtained. the aim of this work was to construct and test a protective dna vaccine based on the gene encoding for the adv non-structural protein 1 (ns1) and to test this construct as a potential vaccine candidate against adv infection or disease. ... | 2005 | 15652664 |
| two mink parvoviruses use different cellular receptors for entry into crfk cells. | mink enteritis virus (mev) and aleutian mink disease parvovirus (adv) are two mink parvoviruses that replicate permissively in crandell feline kidney (crfk) cells. we have used this cell model to examine if these two mink parvoviruses use the same cellular receptor. whereas the cellular receptor for mev is expected to be the transferrin receptor (tfr), the cellular receptor for adv has not been clearly identified. we used short hairpin rnas (shrnas) produced from plasmids to trigger rna interfer ... | 2005 | 16040076 |
| pathogenesis of aleutian mink disease parvovirus and similarities to b19 infection. | aleutian mink disease parvovirus (adv) is an unusual member of the autonomous parvoviruses in both its replication and pathogenesis. infection of newborn mink kits results in an acute disease typified by virus replication in type ii pneumocytes in the lung. this replication is permissive and cytopathic, characterized by the production of high levels of viral replicative intermediates and infectious progeny. however, infection of adult aleutian mink leads to a chronic form of the disease termed a ... | 2005 | 16316395 |
| structure of adeno-associated virus type 4. | adeno-associated virus (aav) is a member of the parvoviridae, belonging to the dependovirus genus. currently, several distinct isolates of aav are in development for use in human gene therapy applications due to their ability to transduce different target cells. the need to manipulate aav capsids for specific tissue delivery has generated interest in understanding their capsid structures. the structure of aav type 4 (aav4), one of the most antigenically distinct serotypes, was determined to 13-a ... | 2005 | 15795290 |
| antibodies to aleutian mink disease parvovirus in free-ranging european mink (mustela lutreola) and other small carnivores from southwestern france. | owing to the rapid decline of the european mink (mustela lutreola) in france, a national conservation action plan has been initiated, in which scientific research to improve understanding of the causes of the decline is one of the primary objectives. in order to investigate the possible role of aleutian disease parvovirus (adv) in decline of the species, a serologic survey was conducted from march 1996 to march 2002 in 420 free-ranging individuals of six species of small carnivores distributed i ... | 2004 | 15465705 |
| structure of adeno-associated virus serotype 5. | adeno-associated virus serotype 5 (aav5) requires sialic acid on host cells to bind and infect. other parvoviruses, including aleutian mink disease parvovirus (adv), canine parvovirus (cpv), minute virus of mice, and bovine parvovirus, also bind sialic acid. hence, structural homology may explain this functional homology. the amino acids required for cpv sialic acid binding map to a site at the icosahedral twofold axes of the capsid. in contrast to aav5, aav2 does not bind sialic acid, but rathe ... | 2004 | 15016858 |
| caspase cleavage of the nonstructural protein ns1 mediates replication of aleutian mink disease parvovirus. | virus-induced apoptosis of infected cells can limit both the time and the cellular machinery available for virus replication. hence, many viruses have evolved strategies to specifically inhibit apoptosis. however, aleutian mink disease parvovirus (adv) is the first example of a dna virus that not only induces apoptosis but also utilizes caspase activity to facilitate virus replication. to determine the function of caspase activity during adv replication, virus-infected cell lysates or purified a ... | 2003 | 12692232 |
| cytokine profiles in adult mink infected with aleutian mink disease parvovirus. | the aim of this study was to examine the levels of gamma interferon (ifn-gamma)-, interleukin 4 (il-4)-, and il-8-producing cells in peripheral blood mononuclear cells from mink infected with the aleutian mink disease parvovirus (adv). as expected, adv-infected mink developed high plasma gamma globulin values (hypergammaglobulinemia) and enhanced quantities of cd8-positive (cd8(+)) cells in the blood during the infection. we quantified the percentages of ifn-gamma- and il-4-positive lymphocytes ... | 2003 | 12805443 |
| caspase activation is required for permissive replication of aleutian mink disease parvovirus in vitro. | aleutian mink disease parvovirus (adv) is distinct among the parvoviruses as infection in vivo is persistent, restricted, and noncytopathic. in contrast, infections with other more prototypic parvoviruses, like mink enteritis virus (mev), are acute, cytopathic, and characterized by permissive replication in vivo. although apoptosis results in the death of cells acutely infected by parvoviruses, the role of apoptosis in adv infections is unknown. permissive infection of adv resulted in apoptosis ... | 2002 | 11878925 |
| aleutian mink disease parvovirus in wild riparian carnivores in spain. | serious declines in populations of native european mink (mustela lutreola) have occurred in europe. one responsible factor may be infectious diseases introduced by exotic american mink (mustela vison). in order to investigate a possible role for aleutian mink disease parvovirus (adv), we surveyed native riparian carnivores and feral american mink. when serum samples from 12 free-ranging european and 16 feral american mink were tested, antibodies to adv were detected from three of nine european m ... | 2001 | 11272488 |
| [dynamic of dnase activity induction in serum of normal animals after heterogeneous dna injection and in hereditary pathology]. | studies of reactions in animals with hereditary diseases (sapphire minks highly sensitive to aleutian disease virus, adv; cba mice with 60-70% incidence of tumors; akr mice with 90% incidence of leukemia) showed that serum dnase activity in these animals dropped after injection of a foreign heterogeneous dna and remained decreased during 72 h. by contrast, serum dnase activity considerably and persistently increased after injection of dna in standard minks resistant to adv, c57bi/6j mice with 1% ... | 2001 | 11392967 |
| nucleotide sequence and polymerase chain reaction/restriction fragment length polymorphism analyses of aleutian disease virus in ferrets in japan. | two ferrets with spontaneous aleutian disease (ad) were found in japan. the diagnosis was verified by polymerase chain reaction (pcr) amplification of part of the capsid gene specific to ad virus (adv). the nucleotide sequences (365 bp in length) of the amplified fragments from the 2 ferrets differed by a single nucleotide, producing an amino acid alteration. compared with other types of adv, these isolates had 96% sequence similarity to a published ferret adv (fadv) in contrast to <91% homology ... | 2001 | 11478607 |
| identification of aleutian mink disease parvovirus capsid sequences mediating antibody-dependent enhancement of infection, virus neutralization, and immune complex formation. | aleutian mink disease parvovirus (adv) causes a persistent infection associated with circulating immune complexes, immune complex disease, hypergammaglobulinemia, and high levels of antiviral antibody. although antibody can neutralize adv infectivity in crandell feline kidney cells in vitro, virus is not cleared in vivo, and capsid-based vaccines have proven uniformly ineffective. antiviral antibody also enables adv to infect macrophages, the target cells for persistent infection, by fc-receptor ... | 2001 | 11602751 |
| nonsuppurative meningoencephalitis associated with aleutian mink disease parvovirus infection in ranch mink. | severe nonsuppurative meningoencephalitis associated with aleutian mink disease parvovirus (adv) infection was observed in adult ranch mink. brain lesions included severe, locally extensive to coalescing lymphoplasmacytic meningoencephalitis with accompanying gliosis, satellitosis, and mild extension of inflammation into the leptomeninges. adv was identified in mesenteric lymph node, spleen, brain, and liver of affected mink by polymerase chain reaction techniques. sequences of the adv isolate ( ... | 2000 | 10730948 |