Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| viral and mycoplasmal pneumonias: reviewing current concepts. | the pathogenesis of viral and mycoplasmal infections is probably similar, but pathologic findings vary, depending on the etiologic agent. in the absence of inclusion bodies in epithelial cells, definitive diagnosis of viral pneumonia depends on isolation of the virus. viral pneumonias are more insidious in onset than bacterial types. in the early stages, physical findings may be minimal. complications include those associated with viremia or bacterial superinfection. culture of a throat swab is ... | 1975 | 1105492 |
| recovery of infectious proviral dna from mammalian cells infected with respiratory syncytial virus. | the dna fraction from a line of bovine embryonic kidney cells originally exposed as primary cultures several months earlier to a temperature-sensitive (ts) mutant of respiratory syncytial (rs) virus could be used to transfect human hep-2 cells with the production of infectious rs virus. the dna donor cells, designated bek/rs ts, retained their healthy fibroblastic appearance during continuous cultivation at a temperature (39 degrees) restrictive for growth of the original infecting mutant and sh ... | 1975 | 1103142 |
| effect of acetone fixation on infectivity and antigenicity of respiratory syncytial virus and adenovirus in the fluorescent antibody test. | an investigation was made on the effect of acetone fixation on infectivity and immunofluorescent antigenicity of respiratory syncytial virus and adenovirus type 5, lipid- and nonlipid-containing viruses, respectively. viruses were allowed to replicate in hep-2 cells, and the cells were then fixed in acetone at 5 c for periods ranging from 30 s to 7 days. treatment for 10 min was sufficient to inactivate respiratory syncytial virus, whereas infectious adenovirus type 5 could be isolated from cell ... | 1975 | 1100650 |
| [infections in children with respiratory syncytial virus. a rapid diagnostic method for virus isolation in the nasopharyngeal aspirate]. | 1975 | 1096354 | |
| respiratory virus disease in malaysian children: a serological study. | paired sera from 101 malaysian children aged up to 10 years and suffering from respiratory illnesses were examined serologically for evidence of respiratory viral infections. of these children, 32.6% showed rising antibody titres for one or more of the test agents. respiratory syncytial virus appeared to be the main respiratory pathogen involved, followed by mycoplasma pneumoniae, parainfluenza viruses, adenoviruses, and influenza a virus. these findings are generally similar to those reported b ... | 1975 | 1084808 |
| a comparison of influenza and respiratory syncytial virus infections among infants admitted to hospital with acute respiratory infections. | among 741 children under 5 years admitted to hospital with respiratory infections during two winters, infection with influenza a virus was diagnosed in 70 (9%), with influenza b virus in 8 (1%), and with respiratory syncytial virus (rsv) in 259 (35%). both influenza virus and rsv infections were diagnosed most frequently in children under the age of one year, and diagnosed more frequently in males than females. influenza illnesses were more severe in boys than girls. both infections occurred mor ... | 1976 | 1069818 |
| events following the infections of enucleate cells with measles virus. | the development of measles virus (edmonston) and sspe measles virus (horta-barbosa) has been examined in enucleate bsc 1 cells. new antigen synthesis in measles virus infected enucleate cells has been demonstrated by fluorescent antibody, by the formation of extensive syncytia from enucleate cells alone and by analysis of polypeptide formation by polyacrylamide gel electrophoresis. all polypeptides formed in nucleate cells were also present in enucleate cells but the amount synthesized was reduc ... | 1976 | 1018171 |
| respiratory syncytial virus infection in north-east england. | during a period covering four winter epidemics 987 respiratory syncytial (rs) virus infections were identified in the children's wards that served a total population of about 875 000 in north-east england. the incidence of admission to hospital with rs virus infection tended to be twice as high among children in tyneside as that among children from the rest of the catchment area. the risk of hospital admission with rs virus infection in the first year of life for city children was about 1 in 50. ... | 1976 | 990783 |
| effect of serum and nasal neutralizing antibodies on bovine respiratory syncytial virus infection in calves. | calves exposed to a bovine respiratory syncytial virus showed mild clinical signs of respiratory illness and responded serologically. the disease occurred in the presence or absence of circulating antibodies, but there was no evidence of exacerbation of the disease due to preexisting serum antibody. nasal secretory antibody appeared to protect the calves against the disease. calves previously exposed to the virus were immune to challenge. the virus was recovered at a high frequency when specimen ... | 1976 | 978005 |
| role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. | fifteen infants with pneumonia caused by respiratory syncytial virus (rsv) and 19 infants with bronchiolitis caused by rsv were studied for the influence of homologous, circulating neutralizing antibody on the severity of their illness. all infants were under nine months of age. although maternal neutralizing antibody did not prevent infection with rsv and illness, the severity of pneumonia caused by rsv was inversely related to the level of neutralizing antibody. the severity of bronchiolitis c ... | 1976 | 977992 |
| [role of bovine respiratory syncytial virus in the aetiology of viruspneumonia in calves and yearlings ("pinkengriep") (author's transl)]. | the clinical picture of "pinkengriep", an enzootic form of bronchopneumonia in young cattle, is described. in addition to cough, conjunctivitis and a soporous state, accelerated respiration initially is an outstanding clinical symptom. in some cases, symptoms of fog fever appear during the second stage of the disease. in the autumn of 1973 and that of 1974, a total number of 292 animals with "pinkengriep" were serologically examined for known respiratory virus infections and chlamydia. complemen ... | 1976 | 968892 |
| isolation of respiratory syncytial virus from patients with lower respiratory tract infections in a paediatric observation ward in kenya. | 1976 | 964190 | |
| respiratory syncytial virus proteins. | 1976 | 960560 | |
| breast-feeding protects against respiratory syncytial virus infections. | eight out of 115 infants admitted to hospital with respiratory syncytial (rs) virus infection had been breast-fed compared with 46 out of 167 controls; this difference was statistically significant. twenty-one specimens of human colostrum were examined, and all contained rs virus neutralising activity. specific iga and igg were detected in 18 specimens, whereas igm was detected in none. the titre of iga antibody was usually higher and correlated more closely to the titre of neutralising activity ... | 1976 | 953560 |
| growth and genetic stability of the ts-1 mutant of respiratory syncytial virus at restrictive temperatures. | an in vitro study was performed to define in greater detail those factors which favored the growth of the ts-1 mutant of respiratory syncytial virus under restrictive conditions and the emergence of genetically altered virus with decreased temperature sensitivity. replication of ts-1 occurred at each of the restrictive temperatures of 37, 38, and 39 c, even through plaque formation was not observed. the level of virus growth under restrictive conditions was inversely related to the incubation te ... | 1976 | 943572 |
| respiratory syncytial virus and influenza. practical community surveillance. | concurrent and sequential outbreaks of infection with respiratory syncytial virus (rsv) and influenza a virus were studied, utilizing a local surveillance system for infectious diseases that involved weekly reports from primary care physicians. the patterns of illness in the community and in hospital admissions were relatively specific for these two viruses, and differed according to whether rsv and influenza a virus occurred together or separately. this surveillance system appeared to be a prac ... | 1976 | 937281 |
| effect of respiratory syncytial virus infection of hela-cell macromolecular synthesis. | cells infected with respiratory syncytial (rs) virus eventually die but there appears to be no specific mechanism for shutting off cellular synthesis of macromolecules. dna and rna synthesis, as measured by the incorporation of labelled thymidine or uridine, do not begin to shut down until some time between 11 and 18 h after infection. by 18 h their rates of synthesis are reduced to approx. 50% for dna and 35% for rna. protein synthesis continues throughout the course of infection at approximate ... | 1977 | 915484 |
| a field outbreak caused by bovine respiratory syncytial virus. | 1977 | 910662 | |
| further characterization of the complementation group b temperature-sensitive mutant of respiratory syncytial virus. | ts-2, a temperature-sensitive and plaque morphology mutant of respiratory syncytial virus and sole representative of complementation group b, was compared with members of the other complementation groups of respiratory syncytial virus (group a [ts-1] and group c [ts-7]). ts-2 was found to be 10- to 1,000-fold more restricted in growth and ability to spread at restrictive temperatures (37, 38, and 39 degrees c) than at the permissive temperature (32 degrees c). in temperature shift-up experiments ... | 1977 | 904033 |
| [chronic infection of hela cells with respiratory syncytial virus]. | chronic infection of hela cells with respiratory syncytial virus (hela-rs) was produced at a multiplicity of infection of 0.00005 tcd50/cell. during 144 days, 21 passages of hela-rs culture were done. the chronically infected cells did not differ from the control culture in the growth pattern and their proliferative activity. the infectious virus was found in the culture fluid with cells at 7 and 14 days after inoculation of the culture. subsequent attempts at isolation of the infectious virus f ... | 1977 | 898888 |
| isolation and characterization of further defective clones of a temperature sensitive mutant (ts-1) of respiratory syncytial virus. | after exposure of the temperature sensitive ts-1 mutant of respiratory syncytial virus to the chemical mutagne, nitrosoguanidine (ng), 2 clones of virus were recovered which were more temperature sensitive and stable genetically than the ts-1 mutant. the initial criterion used for selection of the 2 clones was decreased ability to produce plaques at 36 degrees c. subsequently it was shown that the 2 clones grew less well at the restrictive temperatures of 37 degrees and 38 degrees c than did the ... | 1977 | 889442 |
| mycoplasma pneumonia: a study on hospitalized american patients with pneumonia in vietnam. | a prospective study on consecutively hospitalized pneumonia patients showed that 41.5% of 58 patients had a fourfold rise in the complement-fixation titer for mycoplasma pneumoniae. viral isolation techniques and serologic tests for influenza a1, a2 and b, parainfluenza 1 and 3, respiratory syncytial virus and the adeno virus group yielded only a single positive isolate for influenza a2. serologic tests for melioidosis, leptospirosis, scrub, murine and epidemic typhus and psittacosis were all ne ... | 1977 | 889014 |
| human antibody-dependent cell-mediated cytotoxicity against target cells infected with respiratory syncytial virus. | a chromium release assay was established to study human antibody-dependent cell-mediated cytotoxicity (adcc) of hep 2 cells infected with respiratory syncytial (rs) virus. human peripheral blood lymphocytes in the presence of specific antibody to rs virus caused in vitro lysis of rs virus infected target cells. adcc was detected in sera of infants with rs virus infections and in specimens of colostrum. the ability of serum or colostrum to mediate the cytotoxic reaction appeared to be related to ... | 1977 | 862248 |
| prospects for prevention of bronchiolitis caused by respiratory syncytial virus. | 1977 | 846778 | |
| the shedding and spreading of respiratory syncytial virus. | 1977 | 846775 | |
| respiratory syncytial virus infections. comments. | 1977 | 846773 | |
| apnea associated with respiratory syncytial virus infection in young infants. | the hospital charts of 274 infants under 6 months of age with culture-proved respiratory syncytial virus infections were reviewed. fifty-six infants (20.4%) demonstrated apnea in association with rsv infection. predisposing factors significantly correlated with apnea included premature birth and young chronologic age at the time of virus infection. the clinical implications of this association are discussed. | 1977 | 839330 |
| respiratory syncytial virus in early infancy. circulating antibody and the severity of infection. | forty-one children less than 6 months of age from whom respiratory syncytial virus (rsv) was isolated were divided into groups of varying severity of illness. no relationship was demonstrated between severity of illness and the complement fixation titer to rsv in cord sera, acute sera, or convalescent sera. an increase in igm level of greater or equal to 15 mg/100 ml in association with the rsv infection was seen more frequently in infants who had higher igm levels in their acute sera than in in ... | 1977 | 835529 |
| polypeptides of respiratory syncytial virus. | radiolabeled respiratory syncytial virus was purified from medium that had been harvested from infected hela cell monolayers before it contained much cellular debris. after isopycnic centrifugation in linear gradients prepared with sucrose dissolved in hanks balanced salt solution, almost all the infectivity and most of the radioactivity were recovered in a single band with density from 1.16 to 1.23 g/cm3 and a peak at 1.2 g/cm3. analysis by polyacrylamide gel electrophoresis resolved the purifi ... | 1977 | 833931 |
| cytopathological and cytochemical studies on respiratory viruses in tissue cultured cells. iv. infection with mumps and respiratory syncytial virus. | 1975 | 814094 | |
| quantitative shedding patterns of respiratory syncytial virus in infants. | quantitative shedding patterns of respiratory syncytial virus in 40 infants hospitalized with acute disease of the lower respiratory tract were determined for elucidation of the pathophysiology of infection with the virus. nasal wash specimens were collected on admission and daily thereafter and were tested for the presence and quantities of respiratory syncytial virus. the following pattern of shedding was observed. (1) the virus was shed for prolonged periods. for the first seven days of hospi ... | 1975 | 808581 |
| scanning electron microscopical demonstration of respiratory syncytial virus antigens by immunological markers. | 1975 | 807741 | |
| detection of antibody to respiratory syncytial virus by membrane fluorescence. | an indirect membrane fluorescent antibody technique was established to study hep 2 cells infected with respiratory syncytial (rs) virus. it was possible to detect igg and igm antibody to rs virus in the sera of patients with respiratory infections using this technique. the technique was further applied to the detection of iga antibody to the same virus in colostrum. | 1976 | 793751 |
| the incidence and aetiology of respiratory tract infections in general practice--with emphasis on mycoplasma pneumoniae. | the incidence of respiratory tract infections in patients seeking medical advice at a community care centre (dalby) during 1973 and 1974 was studied. about every third patient seen at this primary health station presented with signs of such infections. in the age groups less than 10, 10-19, 20-39, 40-59 and greater than or equal to 60 years, respiratory tract infections accounted for 65, 45, 32, 18 and 9% of the fotal number of diagnoses made during 1974. the aetiology of acute respiratory tract ... | 1976 | 783048 |
| infections in preschool children in group day care. | viral and bacterial infections in 20 children under 3 years of age were studied in a day centre for 12 weeks. febrile illnesses were found on one occasion in each of 11 children but no serious infection occurred. pneumococci types 6, 9, or 19 were isolated from all children but more often from those with rhinitis or cough. the individual child had an average of 2 viral infections. adenovirus types 1, 2, 5, coxsackievirus type b5, herpes simplex virus or respiratory syncytial virus was isolated f ... | 1976 | 779398 |
| respiratory-syncytial-virus infections, reinfections and immunity. a prospective, longitudinal study in young children. | to better understand acquired immunity to respiratory-syncytial-virus infections, we analyzed data from a 10-year study of respiratory illness in normal children who were followed longitudinally from early infancy. immunity was measured in terms of failure to become infected or reduction in severity of clinical illness upon reinfection. outbreaks of infections occurred seven times over the 10-year-period. during epidemics the attack rate for first infection was 98 per cent. the rate for second i ... | 1979 | 763253 |
| respiratory syncytial virus in nurseries. | 1979 | 759920 | |
| neonatal respiratory syncytial virus infection. | respiratory syncytial virus infections are thought to be uncommon in the first month of life. during a community outbreak, we prospectively studied such infection in our neonatal units. of 82 neonates studied, 66 were hospitalized for six days or longer, and 23 (35 per cent) acquired this virus. four infants died, two unexpectedly. infected infants had a significantly shorter gestation and birth weight. illness was often atypical, with nonspecific signs, especially in infants under three weeks o ... | 1979 | 759915 |
| control of nosocomial respiratory syncytial viral infections. | we evaluated methods to control the spread of respiratory syncytial virus (rsv) on our infants' ward during a community outbreak of rsv infection. methods included isolation and cohorting of infected infants, strict handwashing, use of gowns, and the cohorting of staff to the ill infants. of 123 infants studied, 36 were admitted with rsv infections. of the remaining 87 contact infants, eight (19%) acquired nosocomial rsv disease. three of the eight developed pneumonia and one died. of the 43 sta ... | 1978 | 724317 |
| neutralisation of respiratory syncytial virus by cat serum. | 1978 | 723929 | |
| breast-feeding as protection against respiratory syncytial virus. | 1978 | 719443 | |
| behavior of respiratory syncytial virus in piglet tracheal organ culture. | piglet tracheal organ cultures were infected with respiratory syncytial virus (rsv) and observed for 21 days. light and immunofluorescence microscopy demonstrated destruction of the ciliated epithelial cells and the presence of viral antigens in the epithelium. virus was shed in high titer for 12--19 days. ciliostasis could be quantitated, and it was shown that several strains of rsv grew and damaged tracheal organ cultures in a similar fashion. a temperature-sensitive mutant of rsv, ts-1, was e ... | 1978 | 712118 |
| [study and identification of the respiratory syncytial virus isolated from a leukemic cow]. | a virus was isolated from the lymph nodes of a cow. by its cultural, physical, chemical, and biologic properties it proved identical with the standard bovine respiratory syncytial virus. it multiplied well in cell cultures of calf kidney at ph 7--7.5. introduced in 20-day-old guinea pigs the virus caused anorexia, bristling up of hairs, stunting, and occasionally death. the inoculated guinea pigs developed pneumonia of a proliferative type with langhans' giant cells. the interrlationship between ... | 1978 | 706146 |
| initiation and maintenance of persistent infection by respiratory syncytial virus. | propagation of cells infected with temperature-sensitive (ts) mutants of respiratory syncytial (rs) virus at nonpermissive temperature (39 degrees c) resulted in cytolytic, abortive, or persistent infection, depending on the mutant used to initiate infection. five mutants from complementation group b produced cytolytic or abortive infections, whereas a single mutant (ts1) from group d and a noncomplbmenting mutant produced persistent infections. the persistently infected culture initiated by mut ... | 1978 | 702647 |
| seven complementation groups of respiratory syncytial virus temperature-sensitive mutants. | fifteen temperature-sensitive mutants of the rsn-2 strain of respiratory syncytial virus have been classified into six complementation groups, two of which appeared to be homologous with two of the three complementation groups of the a2 strain described by wright et al. (p. f. wright, m. a. gharpure, d. s. hodes, and r. m. chanock, arch. gesamte virusforsch, 41:238--247). thus seven complementation groups of respiratory syncytial virus, designated a, b, c, d, e, f, and g, have been defined. the ... | 1978 | 702637 |
| determination of human immunoglobulin m rheumatoid factor by a solid-phase radioimmunoassay which uses human immunoglobulin g in antigen-antibody complexes. | a solid-phase radioimmunoassay for the rapid determination of human immunoglobulin m (igm) rheumatoid factor (rf) has been developed. preparation of the solid phase for the assay involved the formation of complexes between respiratory syncytial virus-specific human igg antibodies and virus antigen on the surface of polystyrene balls. binding of serum rf to igg in the immune complex was subsequently detected by 125i-labeled mu-chain-specific antibodies to human igm. the amount of radioactive indi ... | 1978 | 701459 |
| studies on the occurrence and significance of bovine respiratory syncytial virus in saskatchewan. | seventy-six percent of 49 blood samples from saskatchewan cattle had serum antibodies against bovine respiratory syncytial virus. experimental infection of one week and seven month old calves with bovine respiratory syncytial virus (iowa strain) caused transient fever, mucopurulent nasal discharge and coughing but no macroscopic or microscopic lesions attributable to bovine respiratory syncytial virus. | 1978 | 667711 |
| juvenile onset diabetes mellitus in pregnant women: failure to associate with coxsackie b1-6, mumps, or respiratory syncytial virus infections. | 1978 | 660368 | |
| development of in vitro correlates of cell-mediated immunity to respiratory syncytial virus infection in humans. | groups of infants and children with infections due to respiratory syncytial virus (rsv) were tested at the onset of illness and one, two, and five months later for the presence of rsv-specific cell-mediated immunity, as determined by in vitro lymphocyte transformation (ltf) activity, and for complement-fixing (cf) antibody. an ltf response specific for rsv was observed in 65 % of patients, and the response was largely associated with e-rosette-forming thymus-derived (t) lymphocytes. a significan ... | 1978 | 659924 |
| live respiratory syncytial virus vaccine administered parenterally. | 1978 | 652803 | |
| interferon in nasal secretions from infants with viral respiratory tract infections. | interferon levels in nasal secretions of infants under one year of age, and hospitalized with lower repiratory tract disease, were measured during two respiratory infection seasons. in the first year serial secretions from 50 infants with respiratory syncytial virus infection were examined. undetectable or low levels of interferon were found in all samples, and mean levels did not fluctuate significantly in relation to disease and recovery. this was in contrast to anti-rsv iga, which appeared an ... | 1978 | 650342 |
| the tecumseh study of respiratory illness. x. relation of acute infections to smoking, lung function and chronic symptoms. | the relationship of acute respiratory illness and infection to chronic bronchitis was investigated in the community of tecumseh, michigan. families were randomly selected for study from among all those in the community and they were followed for periods of one year. occurrence of acute respiratory illnesses was identified on a weekly basis. frequency of chronic symptoms of cough and sputum production was separately ascertained. lung function studies were performed three times during the course o ... | 1978 | 623090 |
| study of 8-year-old children with a history of respiratory syncytial virus bronchiolitis in infancy. | thirty-five children known to have had respiratory syncytial virus bronchiolitis in infancy were examined at the age of 8 and their respiratory function tested. the results were compared with those in 35 controls matched for age, sex, and social class. although 18 of the children who had had bronchiolitis in infancy had experienced subsequent episodes of wheezing, these were neither severe nor frequent in most cases and had apparently ceased by the age of 8. nevertheless, the mean exercise bronc ... | 1978 | 620129 |
| intramuscular inoculation of live respiratory syncytial virus induces immunity in cotton rats. | intramuscular inoculation of infant or weanling cotton rats with 10(2.2) to 10(4) plaque-forming units of respiratory syncytial virus induced significant or complete resistance to infection in both the upper and lower portions of the respiratory tract. this resistance did not appear to be the result of in vitro neutralization of virus during homogenization of tissue. virus was not recovered from the local site of inoculation after 5 min and was never detected in the respiratory tract of intramus ... | 1979 | 572342 |
| antibody-dependent cell-mediated cytotoxicity against cells infected with respiratory syncytial virus: characterization of in vitro and in vivo properties. | an in vitro 51cr release assay for human antibody-dependent cell-mediated cytotoxicity (adcc) against hela cells infected with respiratory syncytial virus (rsv) has been characterized by using leukophoresed and adherent cell-depleted adult lymphocytes. lymphoytes from rsv seronegative children were also competent as effector cells. sera from children with :1) primary and recurrent natural rsv infections, or 2) live attenuated rsv vaccine infection were examined to characterize the behavior of ad ... | 1979 | 571890 |
| bovine respiratory syncytial virus infection of bovine embryonic lung cultures: enhancement of infectivity with diethylaminoethyl-dextran and virus-infected cells. | the effects of incorporating diethylaminoethyl-dextran (deae-d) in the inoculum with bovine respiratory syncytial virus (brsv) on the infectivity of brsv was evaluated. a concentration of 40 microgram deae-d/ml provided maximal enhancement of infection as determined by the time of onset of cytopathic effect (cpe), the percentage of cells infected by the inoculum, and the amount of virus produced. when deae-d was used in the inoculum, the cpe appeared a day earlier, the percentage of cells infect ... | 1978 | 565198 |
| [respiratory infection epidemic during the winter of 1979 in umbria]. | the aa, report the results of virological and serological investigations performed during an epidemic of acute respiratory diseases in umbria. the epidemic was associated with respiratory syncytial virus; other virus infections were sporadic. | 1979 | 553517 |
| respiratory syncytial virus infection in inbred mice. | respiratory syncytial virus infected the nose and lungs of each of 20 strains of inbred mice, with viral titers varying 100-fold from least permissive to most permissive strains. viral titers appeared to be under genetic control, but did not correlate with the h-2 haplotype. | 1979 | 546793 |
| clinical and radiological studies in children with respiratory syncytial virus infection. | 1979 | 546771 | |
| secretory immunity in influenza. | the dynamics of secretory antibody formation, the duration of secretory antibody preservation, and changes in the concentration of secretory antibodies to antigens other than influenza virus were studied in 64 patients with influenza a, 105 patients with influenza b, and 23 persons who had had influenza a. severe forms of influenza a were accompanied by antibody accumulation in sera and nasal secretions; in some cases of mild forms of this infection, this process was limited by the humoral immun ... | 1979 | 541522 |
| respiratory syncytial virus, 1979: scotland. | 1979 | 526842 | |
| effect of 2-deoxy-d-glucose and glucosamine on bovine respiratory syncytial virus. | 2-deoxy-d-glucose (2-dg) and glucosamine reversibly inhibited the replication and cytopathic effects of bovine respiratory syncytial virus in bovine turbinate cell cultures. the inhibitors were effective when added up to 12 hours after cell cultures were inoculated. their effectiveness decreased as the time between inoculation of cells and drug treatment lengthened. the sugars did not inactivate the virus directly, and inoculation of drug-treated cells in drug-free medium produced normal yield o ... | 1979 | 525934 |
| experimental respiratory syncytial virus infection in feeder-age lambs. | signs of disease, lesions, and serologic response were seen in six 6-month-old-lambs experimentally inoculated with respiratory syncytial virus (rsv). a transient febrile response, mild hyperpnea, and listlessness were seen. multifocal areas of interstitial pneumonia and bronchiolitis were seen in lambs necropsied during the period of clinical response. a serologic response to rsv was seen in all lambs, and rsv was recovered from five lambs. | 1979 | 525890 |
| lesions in lambs experimentally infected with bovine respiratory syncytial virus. | respiratory syncytial virus was inoculated intratracheally into five 1-week-old lambs. three of the lambs responded clinically with fever, hyperpnea, and listlessness. pulmonary lesions consisted of multifocal areas of consolidation, with necrosis of individual epithelial cells of the airways and accumulation of necrotic debris, macrophages, and few neutrophils in terminal airways and alveoli. pulmonary septa in affected areas were infiltrated with numerous macrophages and lymphocytes. viral par ... | 1979 | 525867 |
| respiratory syncytial virus with apnoea treated with theophylline. | 1979 | 522760 | |
| experimentally induced respiratory syncytial viral infection in lambs. | signs of clinical illness, lesions, and seroconversion were observed in lambs experimentally inoculated with a respiratory syncytial virus of bovine origin. signs of clinical illness were mild and consisted of fever and hyperpnea. multifocal areas of interstitial pneumonia were seen in lambs necropsied during the period of clinical response. all lambs seroconverted to viral antigen, and the virus was isolated from two of the lambs. | 1979 | 517825 |
| a respiratory syncytial virus outbreak in a transitional care nursery. | 1979 | 517481 | |
| [the significance of respiratory syncytial virus as pathogen in respiratory tract infections in infants (author's transl)]. | ten out of twenty babies aged up to twelve months and admitted during the months february and march 1978 were shown to be infected with respiratory syncytial virus. during the first 6 months of life the disease usually presents as bronchiolitis. serologically only neutralising antibodies were demonstrable in this age group. iga was usually raised in babies with bronchopneumonia. an allergic reaction between virus antigen and maternal antibodies is considered to occur, assuming an activation of t ... | 1979 | 516739 |
| solid-phase radioimmunoassay of serum immunoglobulin a antibodies to respiratory syncytial virus and adenovirus. | a solid-phase radioimmunoassay for detecting respiratory syncytial virus and adenovirus serum immunoglobulin a (iga) antibodies was developed. an antigen consisting of purified adenovirus type 2 hexons or a crude lysate of respiratory syncytial virus-infected cells was first adsorbed onto polystyrene beads. the coated beads were then incubated with dilutions of serum, and iga antibodies which attached to the solid-phase virus antigen were subsequently detected with 125i-labeled anti-human alpha ... | 1979 | 511988 |
| [results obtained using an attenuated bovine syncytial virus vaccine against bronchopneumonia of yearlings (author's transl)]. | bronchopneumonia of yearlings is a respiratory infection with bovine respiratory syncytial virus (brs virus) occurring as a herd disease in young cattle. in severe cases, the clinical picture is identifiable; characteristic features are laboured respiration and a high morbidity rate. following an acute onset, atypical interstitial pneumonia is observed on postmorten examination and bacteriological studies are negative. an attenuated live brs virus vaccine was used against bronchopneumonia of yea ... | 1979 | 494211 |
| respiratory syncytial virus: a community problem. | 1979 | 486998 | |
| lymphocyte transformation in response to antigens of respiratory syncytial virus. | 1979 | 482291 | |
| presumed respiratory syncytial virus pneumonia in an adolescent compromised host. | a 15-year-old boy with nephrotic syndrome, renal insufficiency, and cutaneous anergy had severe pneumonia with pleural effusion. there was serologic evidence of respiratory syncytial virus infection, and extensive microbiologic, histologic, and serologic studies failed to identify any other etiologic agent. respiratory syncytial virus as a possible cause of severe pneumonia in immunocompromised hosts has not been previously reported. | 1979 | 472848 |
| demonstration of anti-rubella antibody-secreting cells in rheumatoid arthritis patients. | in the present study we describe a plaque-forming cell assay using erythrocytes coated with viral antigen, which detected anti-viral antibody-secreting cells against various viral antigens. these anti-viral antibody-secreting cell were studied in normal individuals with known viral infections and in rheumatoid arthritis patients. rubella anti-viral antibody-secreting cells were present after induction in the peripheral blood of eight out of ten patients. no plaques were seen before induction. sy ... | 1979 | 472665 |
| clinical and physiological manifestations of bronchiolitis and pneumonia. outcome of respiratory syncytial virus. | the physiological abnormalities and clinical correlates of 32 infants consecutively hospitalized with lower respiratory tract disease from respiratory syncytial virus (rsv) were studied in an attempt to characterized the infant most at risk for the acute and long-term complications of rsv infection. arterial oxygen saturation (sao2) determinations were obtained daily by means of an ear oximeter. on admission all infants were hypoxemic with a mean sao2 of 87% (range, 74% to 95%). the mean of the ... | 1979 | 463835 |
| characterization and identification of a bovine respiratory syncytial virus isolated from young calves. | two identical viruses designated 371 and 375 were recovered from nasal secretions of 2 of 7 calves in a beef cow-calf herd in which calves (45 to 105 days of age) had signs of acute respiratory tract disease. the cytopathic, morphologic and physico-chemical characteristics of the isolates were those of bovine respiratory syncytial virus. although a humoral antibody response to bovine respiratory syncytial virus was not observed, it was concluded that this virus probably had a part in the respira ... | 1979 | 453673 |
| the etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. | to develop a broad understanding of the causes and patterns of occurrence of wheezing associated respiratory infections, we analyzed data from an 11-year study of acute lower respiratory illness in a pediatric practice. although half of the wari occurred in children less than 2 years of age, wheezing continued to be observed in 19% of children greater than 9 years of age who had lower respiratory illness. males experienced lri 1.25 times more often than did females; the relative risk of males fo ... | 1979 | 448557 |
| long-term epidemiology of infections with mycoplasma pneumoniae. | pneumonia due to mycoplasma pneumoniae was monitored in a large prepaid medical-care group in seattle, washington, between 1963 and 1975. the disease was diagnosed by isolation of m. pneumoniae and/or significant rises in titer of complement-fixing (antilipid) antibody in paired sera. infection was endemic without significant seasonal fluctuations. two epidemics occurred: the first peaked in january 1967, the second late in the summer of 1974. total rates of pneumonia infection in children incre ... | 1979 | 448195 |
| ontogeny of the ferret humoral immune response. | infant ferrets are born with nearly undetectable immunoglobulin levels, but by 9 days of age the infant ferret serum contains 77, 29, and 13% of adult mean serum levels of igg, iga, and igm. transmucosal uptake of igg by the infant ferret occurred for the first 30 days of life. the specific anti-respiratory syncytial virus neutralizing titer of whole milk was 5.5 times higher than maternal serum despite a lower concentration of immunoglobulins in the milk. | 1979 | 448158 |
| immunoprophylaxis of respiratory syncytial virus infection in the infant ferret. | infant ferrets can be protected from respiratory syncytical virus challenge at 3 days of age by gestational infection of their mothers. ferrets acquire their immunity to respiratory syncytial virus postpartum via immunizing products of lactation. the level of protection against viral replication correlates with the maternal serum neutralizing titer or a concomitant factor. passive administration of adult ferret serum with a neutralizing titer of 1:1024 or greater, either i.p. or orally does not ... | 1979 | 448139 |
| measles and rubella virus antibodies in patients with multiple sclerosis. a longitudinal study of serum and csf specimens by radioimmunoassay. | a longitudinal study on rubella, measles, and respiratory syncytial virus antibodies in serial serum and csf specimens from 20 multiple sclerosis (ms) patients was performed, using solid-phase radioimmunoassay. albumin and immunoglobulin g (igg) levels were also measured to check the integrity of the blood-brain barrier and the intrathecal igg production. all the patients had local igg production in their cna. a local antibody production against one or more of the viruses studied was evident in ... | 1979 | 444095 |
| respiratory syncytial virus polypeptides: their location in the virion. | 1979 | 442538 | |
| respiratory syncytial virus and sudden infant death. | 1979 | 440397 | |
| respitory syncytial virus and sudden infant death. | 1979 | 440396 | |
| respiratory syncytial virus and sudden infant death. | 1979 | 440395 | |
| the polypeptides of human respiratory syncytial virus: products of cell-free protein synthesis and post-translational modifications. | 1979 | 425320 | |
| cell-mediated immune response to respiratory syncytial virus infection: relationship to the development of reactive airway disease. | the possibility that cell-mediated immunity might play a role in the pathogenesis of infection with respiratory syncytial virus was evaluated in a study of 39 infants. infection with rsv was confirmed by identification of virus in nasopharyngeal secretions using immunofluorescence, and by tissue culture infectivity. cmi, as determined by a whole blood lymphocyte transformation technique, was evaluated in samples taken 0 to 10 and 20 to 60 days after the onset of illness. patients diagnosed as ha ... | 1979 | 423016 |
| cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection. | twenty-two infants under 9 months of age hospitalized with bronchiolitis or pneumonia due to respiratory syncytial virus (rsv) were serially sampled to determine the pattern of secretory antibody response. using double labeling techniques, we found several types of immunoglobulin in secretions: cell-free antibody to rsv of the immunoglobulin a (iga), immunoglobulin g (igg), and immunoglobulin m (igm) classes; and immunoglobulins of all three classes bound to rsv-infected cells shed from the nasa ... | 1979 | 422241 |
| reye's syndrome associated with respiratory syncytial virus infection. | an upper respiratory tract infection in a 22-month-old boy was followed by rapid loss of consciousness, hypoglycaemia, uraemia, and death. necropsy examination showed fatty change of liver and kidneys, severe cerebral oedema, bronchiolitis, and endocardial fibroelastosis affecting the left ventricle. immunofluorescence staining showed infection with respiratory syncytial virus (rsv). the clinical and pathological findings were those of reye's syndrome, not previously reported accompanying rsv in ... | 1979 | 420528 |
| further investigations of live respiratory syncytial virus vaccine administered parenterally. | 1979 | 419156 | |
| experimental respiratory syncytial virus infection of four species of primates. | four species of nonhuman primates were inoculated intranasally with 10(3.1) to 10(3.7) plaque forming units (pfu) of respiratory syncytial (rs) virus. adults squirrel monkeys and newborn rhesus monkeys became infected and shed small quantities (peak titer 10(2.0) pfu/ml of nasopharyngeal swab specimen) of virus, but illness did not develop. infant cebus monkeys aged 2 months became infected, shed 10(2.3) to 10(3.8) pfu/ml of nasopharyngeal swab specimen, but did not become ill. chimpanzees aged ... | 1977 | 416176 |
| respiratory syncytial virus infection in adults: clinical, virologic, and serial pulmonary function studies. | we prospectively studied 10 previously healthy adults who developed an acute respiratory illness while working in an infants' ward during a community outbreak of respiratory syncytial virus infection. in addition to clinical and viral evaluation, total respiratory resistance before and after carbachol aerosol inhalation was measured. all 10 subjects had respiratory syncytial virus infection documented by viral isolation, and all developed pronounced cough, nasal congestion, and fever. eight subj ... | 1978 | 415653 |
| respiratory syncytial virus infections. comments. | 1977 | 403500 | |
| nosocomial respiratory syncytial virus infections in an intensive care nursery: rapid diagnosis by direct immunofluorescence. | a nosocomial outbreak of respiratory syncytial virus infections involved 8 of 17 infants in an intensive care nursery and one additional infant in the adjoining newborn nursery. immunofluorescent staining of nasopharyngeal specimens was positive in six of seven virologically confirmed cases (86%). one additional case with negative viral cultures was also identified by this technique. viral isolation in tissue cultures required an average of 4.9 days, whereas results of immunofluorescent studies ... | 1979 | 382079 |
| detection of respiratory syncytial virus in nasal secretions from infants by enzyme-linked immunosorbent assay. | an enzyme-linked immunosorbent assay (elisa) was developed for detection of respiratory syncytial virus (rsv) in nasal secretions from infants with respiratory disease. rsv was detected in 23 of 29 secretions positive for rsv by tissue culture and in one of 36 samples negative for rsv by tissue culture. the elisa was a simple rapid, and surprisingly sensitive test for identification of rsv infection in infants. | 1979 | 374650 |
| the pathogenesis of respiratory syncytial virus infection in cotton rats. | the cotton rat is susceptible to respiratory synctial virus infection in both the upper and lower portions of the respiratory tract. virus replicates to high titer in the nose and lungs and to relatively low titer in the trachea. immunofluorescence studies demonstrated viral antigen in the nasal epithelium and the bronchial and bronchiolar epithelium but not in the trachea or the alveolar cells of the lungs. histopathologic changes included a desquamative, exudative rhinitis of moderate severity ... | 1978 | 362946 |
| respiratory syncytial virus infection. rapid diagnosis in children by use of indirect immunofluorescence. | specimens of 387 nasopharyngeal suction smears obtained from 354 children hospitalized with acute respiratory infections during an eight-month period were examined for the presence of respiratory syncytial (rs) virus by the indirect immunofluorescence antibody technique (ifat) and by conventional tissue culture infectivity techniques. respiratory syncytial virus was identified in nasopharyngeal suction smear specimens from 123 of these specimens (32%) with the use of both techniques. of the spec ... | 1978 | 362894 |
| respiratory syncytial virus infection: admissions to hospital in industrial, urban, and rural areas. report to the medical research council subcommittee on respiratory syncytial virus vaccines. | a collaborative study of 10 centres during the winters of 1973-4 and 1974-5 showed that respiratory syncytial virus (rsv) was the major cause of admission to hospital for respiratory disease in children under 5 years of age in industrial, urban, and rural communities. in all areas the distribution of clinical symptoms and their severity was similar, but the rate of admission in relation to population was over twice as high in industrial as in other areas. the maximum yearly admission rate occurr ... | 1978 | 359099 |
| the immunologic response to infection with respiratory syncytial virus in infants. | fifty infants younger than six months, hospitalized for infection with respiratory syncytial virus (rsv), were studied by examination of serial samples of nasal secretion. secretory neutralizing activity was measured by plaque reduction and secretory antibody by indirect fluorescence using conjugated antiserum to human iga, igg, or igm. secretory neutralizing activity during infection rose or fell fourfold with approximately equal frequency (20% and 26%, respectively). in contrast, levels of iga ... | 1978 | 355574 |
| pathogenesis of respiratory syncytial virus infection in ferret and fetal human tracheas in organ culture. | the pathogenesis of human respiratory syncytial virus infection was studied in ferret and fetal human tracheas in organ culture. although the patterns of virus growth were similar in these species, the sites and morphologic consequences of virus replication differed markedly. in human trachea, synthesis of respiratory syncytial virus occurred in a population of ciliated epithelial cells, whereas other cells in the epithelial layer were spared. virus replication was associated with cell injury ch ... | 1978 | 354444 |