Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| viral pathogens among elderly people with acute respiratory infections in shanghai, china: preliminary results from a laboratory-based surveillance, 2012-2015. | acute respiratory infections (aris), with viral pathogens as the major contributors, are the most common illnesses worldwide, and increase the morbidity and mortality among the elderly population. the clinical and pathological features of elderly people with aris need to be identified for disease intervention. from january 1(st) , 2012 through december 31(st) , 2015, respiratory specimens from patients above 60 years old with aris were collected from the outpatient and inpatient settings of six ... | 2016 | 27943329 |
| safety, tolerability, and pharmacokinetics of medi8897, the respiratory syncytial virus prefusion f-targeting monoclonal antibody with an extended half-life, in healthy adults. | prevention of respiratory syncytial virus (rsv) illness in infants is a major public health priority, but there is no approved vaccine. palivizumab is a monoclonal antibody that provides rsv prophylaxis but requires 5 monthly injections and is approved only for infants who experience the greatest morbidity and mortality from rsv. thus, there remains a significant unmet medical need for prevention of rsv disease in healthy infants. medi8897 is a recombinant human rsv monoclonal antibody with a mo ... | 2017 | 27956428 |
| correction: effects of chronologic age and young child exposure on respiratory syncytial virus disease among us preterm infants born at 32 to 35 weeks gestation. | [this corrects the article doi: 10.1371/journal.pone.0166226.]. | 2016 | 27959962 |
| commentary: blood eosinophilia is associated with unfavorable hospitalization outcomes in children with bronchiolitis. | 2016 | 27965947 | |
| virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice. | respiratory syncytial virus (rsv) is a leading cause of lower respiratory infection in infants and children, but there is still no licensed vaccine available. in this report, we developed virus-like particle (vlp) vaccines based on the bac-to-bac baculovirus expression system, consisting of an influenza virus matrix (m1) protein and the rsv fusion protein (f) or glycoprotein (g). these rsv vlps were identified by western blot analysis and electron microscopy. female balb/c mice immunized intrana ... | 2017 | 27974288 |
| detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles. | accurate diagnosis of influenza viruses is difficult and generally requires a complex process because of viral diversity and rapid mutability. in this study, we report a simple and rapid strategy for the detection and differentiation of influenza viruses using glycan-functionalized gold nanoparticles (ggnps). this method is based on the aggregation of ggnp probes on the viral surface, which is mediated by the specific binding of the virus to the glycans. using a set of ggnps bearing different gl ... | 2017 | 27987410 |
| [after the epidemic - before the epidemic. incidence of bronchiolitis at the pediatric ward of the bács-kiskun county hospital]. | bronchiolitis may cause severe respiratory insufficiency in infants and toddlers. respiratory syncytial virus (rsv) is its most frequent infective agent. | 2016 | 27989226 |
| development of bioluminescence imaging of respiratory syncytial virus (rsv) in virus-infected live mice and its use for evaluation of therapeutics and vaccines. | respiratory syncytial virus (rsv) is one of the leading causes of pneumonia among infants with no human vaccine or efficient curative treatments. efforts are underway to develop new rsv vaccines and therapeutics. there is a dire need for animal models for preclinical evaluation and selection of products against rsv. herein, we developed a whole body bioluminescence imaging to follow replication of rsv a2 virus strain expressing firefly luciferase (rsva2-line19-ffl) in live balb/c mice that can b ... | 2017 | 27989627 |
| vaccination against respiratory syncytial virus in pregnancy. | 2016 | 27998593 | |
| respiratory syncytial virus-induced paediatric ards: why we should unpack the syndrome. | 2017 | 28000595 | |
| a live rsv vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation. | respiratory syncytial virus (rsv) is a leading cause of infant hospitalization and there remains no pediatric vaccine. rsv live-attenuated vaccines (lavs) have a history of safe testing in infants; however, achieving an effective balance of attenuation and immunogenicity has proven challenging. here we seek to engineer an rsv lav with enhanced immunogenicity. genetic mapping identifies strain line 19 fusion (f) protein residues that correlate with pre-fusion antigen maintenance by elisa and ther ... | 2016 | 28000669 |
| seasonality of influenza and respiratory syncytial viruses and the effect of climate factors in subtropical-tropical asia using influenza-like illness surveillance data, 2010 -2012. | the seasonality of influenza and respiratory syncytial virus (rsv) is well known, and many analyses have been conducted in temperate countries; however, this is still not well understood in tropical countries. previous studies suggest that climate factors are involved in the seasonality of these viruses. however, the extent of the effect of each climate variable is yet to be defined. | 2016 | 28002419 |
| development of a multiplex rt-pcr for simultaneous diagnosis of human metapneumovirus (hmpv) and human respiratory syncytial virus (hrsv) from clinical specimens. | human metapneumovirus (hmpv) and human respiratory syncytial virus (hrsv) are ubiquitous respiratory viral pathogens. they belong to the family paramyxoviridae (subfamily pneumovirinae) and is responsible for acute respiratory tract infections in children, elderly and immunocompromised patients. we designed and tested a multiplex reverse transcriptase polymerase chain reaction (mrt-pcr) as a cost-effective alternative to real-time pcr and cell culture based detection for hmpv and hrsv. the newly ... | 2016 | 28004017 |
| respiratory syncytial virus infection-associated hospitalization rates in infants and children with cystic fibrosis. | infections with respiratory syncytial virus (rsv) are the leading cause for hospital admissions in infants and young children. the incidence of rsv-related hospitalizations in patients with cystic fibrosis (cf) is unclear. to date, no effective treatment for rsv infections is available. thus, prophylaxis with the monoclonal antibody palivizumab is an important option. | 2017 | 28005688 |
| pneumovirus-induced lung disease in mice is independent of neutrophil-driven inflammation. | the human pneumovirus respiratory syncytial virus (rsv) is the most common pathogen causing lower respiratory tract disease in young children worldwide. a hallmark of severe human rsv infection is the strong neutrophil recruitment to the airways and lungs. massive neutrophil activation has been proven detrimental in numerous diseases, yet in rsv the contribution of neutrophils to disease severity, and thereby, the relevance of targeting them, is largely unknown. to determine the relevance of pot ... | 2016 | 28005954 |
| development of a global respiratory severity score for respiratory syncytial virus infection in infants. | respiratory syncytial virus (rsv) infection in infants has recognizable clinical signs and symptoms. however, quantification of disease severity is difficult, and published scores remain problematic. thus, as part of a rsv pathogenesis study, we developed a global respiratory severity score (grss) as a research tool for evaluating infants with primary rsv infection. | 2017 | 28011907 |
| nasopharyngeal pneumococcal carriage during childhood community-acquired alveolar pneumonia: relationship between specific serotypes and coinfecting viruses. | respiratory viruses and streptococcus pneumoniae are known to be copathogens in childhood pneumonia. however, it is unclear whether all pneumococcal serotypes are equally prone to such interaction. we attempted to determine association between carried pneumococcal serotypes and respiratory viruses during childhood community-acquired alveolar pneumonia (caap). | 2017 | 28011920 |
| prevalence of co-infection between respiratory syncytial virus and influenza in children. | respiratory syncytial virus (rsv) and influenza have varying degree of seasonal overlap. | 2017 | 28012809 |
| viral agents causing acute respiratory infections in children under five: a study from eastern india. | background. acute respiratory infections (aris) are important cause of mortality and morbidity in children under five in developing country. methods. this observational study was conducted over two-year period in a tertiary care teaching hospital of eastern india. nasal and throat swabs were collected, transported to the laboratory at 2-8°c in viral transport media, and then processed for detection of viruses using mono/multiplex real-time polymerase chain reaction. results. a total of 300 child ... | 2016 | 28018433 |
| autophagy, tgf-β, and smad-2/3 signaling regulates interferon-β response in respiratory syncytial virus infected macrophages. | human respiratory syncytial virus (rsv) is a lung tropic virus causing severe airway diseases including bronchiolitis and pneumonia among infants, children, and immuno-compromised individuals. rsv triggers transforming growth factor-β (tgf-β) production from lung epithelial cells and tgf-β facilitates rsv infection of these cells. however, it is still unknown whether rsv infected myeloid cells like macrophages produce tgf-β and the role of tgf-β if any during rsv infection of these cells. our st ... | 2016 | 28018859 |
| hospital admissions for lower respiratory tract infections among infants in the canadian arctic: a cohort study. | it is unknown whether this burden of disease of lower respiratory tract infections is comparable across the canadian arctic. the objectives of this surveillance study were to compare the rates of hospital admission for lower respiratory tract infection and the severity of infection across arctic canada, and to describe the responsible viruses. | 2016 | 28018874 |
| how efficacious are vaccines against bovine respiratory syncytial virus in cattle? | bovine respiratory syncytial virus (brsv) is a paramyxovirus that is the major cause of pneumonia in calves. vaccines for this important pathogen have been available since the late 1970's. this review is a critical assessment of the literature including, experimental challenge studies and field trials, that address the efficacy of commonly used vaccines to control respiratory disease caused by brsv. | 2016 | 28024854 |
| pulmonary hemorrhage as a complication of respiratory syncyntial virus (rsv) bronchiolitis. | respiratory syncytial virus (rsv) is a common cause of bronchiolitis. although there are a number of recognized complications, pulmonary hemorrhage has not been reported previously. a retrospective case notes review was performed through an electronic search of a pediatric intensive care unit's medical records. seven patients with rsv infection and pulmonary hemorrhage were identified and included in this case series. six of the seven patients were born prematurely (30-36 weeks gestation). all p ... | 2017 | 28029754 |
| respiratory syncytial virus. | 2017 | 28030703 | |
| new insights into structural disorder in human respiratory syncytial virus phosphoprotein and implications for binding of protein partners. | phosphoprotein is the main cofactor of the viral rna polymerase of mononegavirales it is involved in multiple interactions that are essential for the polymerase function. most prominently it positions the polymerase complex onto the nucleocapsid, but also acts as a chaperone for the nucleoprotein. mononegavirales phosphoproteins lack sequence conservation, but contain all large disordered regions. we show here that n- and c-terminal intrinsically disordered regions account for 80% of the phospho ... | 2017 | 28031463 |
| environmental factor and inflammation-driven alteration of the total peripheral t-cell compartment in granulomatosis with polyangiitis. | autoimmune diseases are initiated by a combination of predisposing genetic and environmental factors resulting in self-perpetuating chronic inflammation and tissue damage. autoantibody production and an imbalance of effector and regulatory t-cells are hallmarks of autoimmune dysregulation. while expansion of circulating effector memory t-cells is linked to disease pathogenesis and progression, the causes driving alterations of the peripheral t-cell compartment have remained poorly understood so ... | 2017 | 28040323 |
| burden of healthcare-associated viral respiratory infections in children's hospitals. | although healthcare-associated (ha) viral respiratory infections (vris) are common in pediatrics, no benchmark for comparison exists. we aimed to determine, compare, and assess determinants of unit-specific ha-vri incidence rates in 2 children's hospitals. | 2016 | 28040689 |
| expression and antigenicity of recombinant human respiratory syncytial virus glycoproteins having different affinity tags. | human respiratory syncytial virus (hrsv) is a main cause of lower respiratory tract infections in infants and the elderly. glycoprotein (g) is major antigen on the viral surface, and plays a key role for virus entry. therefore, purification of the glycoprotein of hrsv is critical for the development of hrsv vaccine and serological diagnosis. in this study, we report the design and characterization of glycoprotein engineered rationally to enhance the protein solubility and to facilitate efficient ... | 2017 | 28042093 |
| macromolecular prodrugs of ribavirin: structure-function correlation as inhibitors of influenza infectivity. | the requirement for new antiviral therapeutics is an ever present need. particularly lacking are broad spectrum antivirals that have low toxicity. we develop such agents based on macromolecular prodrugs whereby both the polymer chain and the drug released from the polymer upon cell entry have antiviral effects. specifically, macromolecular prodrugs were designed herein based on poly(methacrylic acid) and ribavirin. structure-function parameter space was analyzed via the synthesis of 10 polymer c ... | 2017 | 28043136 |
| glucocorticoid insensitivity in virally infected airway epithelial cells is dependent on transforming growth factor-β activity. | asthma and chronic obstructive pulmonary disease (copd) exacerbations are commonly associated with respiratory syncytial virus (rsv), rhinovirus (rv) and influenza a virus (iav) infection. the ensuing airway inflammation is resistant to the anti-inflammatory actions of glucocorticoids (gcs). viral infection elicits transforming growth factor-β (tgf-β) activity, a growth factor we have previously shown to impair gc action in human airway epithelial cells through the activation of activin-like kin ... | 2017 | 28046097 |
| genetic stability of genome-scale deoptimized rna virus vaccine candidates under selective pressure. | recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. these vaccine candidates should have a low risk of deattenuation because of the many changes involved. however, their genetic stability under selective pressure is largely unknown. we evaluated phenotypic reversion of deoptimized human respiratory syncytial virus (rsv) vaccine candidates in the context of strong selective pressure. codon pair deoptimized (cpd) versions of rsv w ... | 2017 | 28049853 |
| compassionate use experience with high-titer respiratory syncytical virus (rsv) immunoglobulin in rsv-infected immunocompromised persons. | respiratory syncytial virus (rsv) may cause fatal lower respiratory tract infection (lrti) in immunocompromised patients. ribavirin with or without standard intravenous immunoglobulin (ivig) is frequently given although efficacy is debated. infusion of ivig with high levels of neutralizing antibody against rsv may offer benefit in these patients. | 2017 | 28054734 |
| thymus activity measured by t-cell receptor excision circles in patients with different severities of respiratory syncytial virus infection. | respiratory syncytial virus (rsv) infection is an important cause of hospitalization in previously healthy infants. immunological mechanisms predisposing infants to severe disease are poorly understood. early biomarkers for disease severity may assist clinical decisions. we investigated t-cell receptor excision circles (trec), episomal dna made during thymic t-cell receptor rearrangement, and a marker for thymus activity, both during disease and in neonatal screening cards as a risk factor for r ... | 2017 | 28056841 |
| estimating the burden of respiratory syncytial virus (rsv) on respiratory hospital admissions in children less than five years of age in england, 2007-2012. | respiratory syncytial virus (rsv) is a leading cause of hospital admission in young children. with several rsv vaccines candidates undergoing clinical trials, recent estimates of rsv burden are required to provide a baseline for vaccine impact studies. | 2017 | 28058797 |
| excess respiratory viral infections and low antibody responses among hiv-exposed, uninfected infants. | hiv-exposed uninfected (heus) infants have frequent severe infection, hospitalization, and death. we performed a serologic investigation to determine the role of common childhood respiratory pathogens in the excess incidence of infections in heus. | 2017 | 28060016 |
| a neonatal murine model of mrsa pneumonia. | pneumonia due to methicillin-resistant staphylococcus aureus (mrsa) is a significant cause of morbidity and mortality in infants particularly following lower respiratory tract viral infections such as respiratory syncytial virus (rsv). however, the mechanisms by which co-infection of infants by mrsa and rsv cause increased lung pathology are unknown. because the infant immune system is qualitatively and quantitatively different from adults we developed a model of infant mrsa pneumonia which will ... | 2017 | 28060871 |
| [rapid diagnostic test for respiratory infections]. | acute respiratory infections are the second cause of morbidity and mortality in children and adults worldwide, being viruses, bacteria and fungi involved in their etiology. the rapid diagnosis allows for a better clinical management of the patient, for adopting public health measures and for controlling possible outbreaks. the main etiologic agents can be diagnosed within the first hours after the onset of symptoms with antigen detection techniques, primarily immunochromatography. results are ob ... | 2017 | 28062161 |
| c-jun n-terminal kinase activity is required for efficient respiratory syncytial virus production. | respiratory syncytial virus (rsv) is a major cause of respiratory infections in infants and the elderly, leading to more deaths than influenza each year worldwide. with no rsv antiviral or efficacious vaccine currently available, improved understanding of the host-rsv interaction is urgently required. here we examine the contribution to rsv infection of the host stress-regulated c-jun n-terminal kinase (jnk), for the first time. peak jnk1/2 phosphoactivation is observed at ∼24 h post-infection, ... | 2017 | 28062184 |
| epidemiological and clinical features of enteroviral acute lower respiratory tract infections in hospitalized paediatric patients in a malaysian tertiary center. | human enteroviruses (hevs) have been recognized to cause a significant number of respiratory tract infections in many regions. previous studies conducted to analyse enteroviral respiratory tract infections focused on outbreaks. data in the southeast asian region is still rather limited to date. | 2016 | 28064293 |
| paramyxovirus outbreak in a long-term care facility: the challenges of implementing infection control practices in a congregate setting. | objective we report an outbreak of respiratory syncytial virus (rsv) and human metapneumovirus (hmpv) infections in a dementia care ward containing 2 separately locked units (a and b) to heighten awareness of these pathogens in the older adult population and highlight some of the infection prevention challenges faced during a noninfluenza respiratory viral outbreak in a congregate setting. methods cases were defined by the presence of new signs or symptoms that included (1) a single oral tempera ... | 2017 | 28065183 |
| a single, low dose of a cgmp recombinant bcg vaccine elicits protective t cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice. | human respiratory syncytial virus (hrsv) is a major health burden worldwide, causing the majority of hospitalizations in children under two years old due to bronchiolitis and pneumonia. hrsv causes year-to-year outbreaks of disease, which also affects the elderly and immunocompromised adults. furthermore, both hrsv morbidity and epidemics are explained by a consistently high rate of re-infections that take place throughout the patient life. although significant efforts have been invested worldwi ... | 2017 | 28065474 |
| quantification and determinants of the amount of respiratory syncytial virus (rsv) shed using real time pcr data from a longitudinal household study. | background a better understanding of respiratory syncytial virus (rsv) epidemiology requires realistic estimates of rsv shedding patterns, quantities shed, and identification of the related underlying factors. methods rsv infection data arise from a cohort study of 47 households with 493 occupants, in coastal kenya, during the 2009/2010 rsv season. nasopharyngeal swabs were taken every 3 to 4 days and screened for rsv using a real time polymerase chain reaction (pcr) assay. the amount of virus s ... | 2016 | 28066826 |
| antiviral therapy for respiratory viral infections in immunocompromised patients. | respiratory viruses (influenza, parainfluenza, respiratory syncytial virus, coronavirus, human metapneumovirus, and rhinovirus) represent the most common causes of respiratory viral infections in immunocompromised patients. also, these infections may be more severe in immunocompromised patients than in the general population. early diagnosis and treatment of viral infections continue to be of paramount importance in immunocompromised patients; because once viral replication and invasive infectio ... | 2017 | 28067078 |
| conditioned medium from persistently rsv-infected macrophages alters transcriptional profile and inflammatory response of non-infected macrophages. | cells susceptible to persistent viral infections undergo important changes in their biological functions as a consequence of the expression of viral gene products that are capable of altering the gene expression profile of the host cell. previously, we reported that persistence of the rsv genome in a mouse macrophage cell line induces important alterations in cell homeostasis, including constitutive expression of ifn-β and other pro-inflammatory cytokines. here, we postulated that changes in the ... | 2017 | 28069520 |
| development of a one-run real-time pcr detection system for pathogens associated with bovine respiratory disease complex. | bovine respiratory disease complex (brdc) is frequently found in cattle worldwide. the etiology of brdc is complicated by infections with multiple pathogens, making identification of the causal pathogen difficult. here, we developed a detection system by applying taqman real-time pcr (dembo respiratory-pcr) to screen a broad range of microbes associated with brdc in a single run. we selected 16 bovine respiratory pathogens (bovine viral diarrhea virus, bovine coronavirus, bovine parainfluenza vi ... | 2017 | 28070089 |
| glutathione peroxidase-1 suppresses the unfolded protein response upon cigarette smoke exposure. | oxidative stress provokes endoplasmic reticulum (er) stress-induced unfolded protein response (upr) in the lungs of chronic obstructive pulmonary (copd) subjects. the antioxidant, glutathione peroxidase-1 (gpx-1), counters oxidative stress induced by cigarette smoke exposure. here, we investigate whether gpx-1 expression deters the upr following exposure to cigarette smoke. expression of er stress markers was investigated in fully differentiated normal human bronchial epithelial (nhbe) cells iso ... | 2016 | 28070146 |
| defining the risk and associated morbidity and mortality of severe respiratory syncytial virus infection among infants with congenital heart disease. | the regal (rsv evidence-a geographical archive of the literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (rsv) in western countries over the last 20 years. this fourth publication covers the risk and burden of rsv infection in infants with congenital heart disease (chd). | 2017 | 28070870 |
| pathogens, patterns of pneumonia, and epidemiologic risk factors associated with respiratory disease in recently weaned cattle in ireland. | we examined the pathogens, morphologic patterns, and risk factors associated with bovine respiratory disease (brd) in 136 recently weaned cattle ("weanlings"), 6-12 mo of age, that were submitted for postmortem examination to regional veterinary laboratories in ireland. a standardized sampling protocol included routine microbiologic investigations as well as polymerase chain reaction and immunohistochemistry. lungs with histologic lesions were categorized into 1 of 5 morphologic patterns of pneu ... | 2017 | 28074713 |
| monoclonal antibody against g glycoprotein increases respiratory syncytial virus clearance in vivo and prevents vaccine-enhanced diseases. | respiratory syncytial virus (rsv) is a common cause of lower respiratory tract illness in infants, young children, and the elderly. the g glycoprotein plays a role in host cell attachment and also modulates the host immune response, thereby inducing disease pathogenesis. we generated two monoclonal antibodies (mabs; 5h6 and 3a5) against g protein core fragment (gcf), which consisted of amino acid residues 131 to 230 from rsv a2 g protein. epitope mapping study revealed that 5h6 specifically bind ... | 2017 | 28076422 |
| single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen. | the number of viral pathogens associated with pediatric acute respiratory tract infection (ari) has grown since the introduction of reverse transcription real-time polymerase chain reaction (rt-pcr) assays. multiple viruses are detected during a single ari episode in approximately a quarter of all cases. the clinical relevance of these multiple detections is unclear, as is the role of the individual virus. we therefore investigated the correlation between clinical data and rt-pcr results in chil ... | 2017 | 28077074 |
| effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients. | respiratory syncytial virus (rsv) is a frequent cause of respiratory viral infections, increasing the morbidity and mortality in allogeneic haematopoietic stem cell transplantation (hsct) recipients. little is known about the best management strategy in this immunocompromised group and there are very few data on oral ribavirin treatment. | 2017 | 28077243 |
| notch ligand delta-like 4 promotes regulatory t cell identity in pulmonary viral infection. | regulatory t (treg) cells establish tolerance, prevent inflammation at mucosal surfaces, and regulate immunopathology during infectious responses. recent studies have shown that delta-like ligand 4 (dll4) was upregulated on apc after respiratory syncytial virus (rsv) infection, and its inhibition leads to exaggerated immunopathology. in the present study, we outline the role of dll4 in treg cell differentiation, stability, and function in rsv infection. we found that dll4 was expressed on cd11b( ... | 2017 | 28077598 |
| brd4 couples nf-κb/rela with airway inflammation and the irf-rig-i amplification loop in respiratory syncytial virus infection. | the airway mucosa expresses protective interferon (ifn) and inflammatory cytokines in response to respiratory syncytial virus (rsv) infection. in this study, we examine the role of bromodomain containing 4 (brd4) in mediating this innate immune response in human small airway epithelial cells. we observe that rsv induces brd4 to complex with nf-κb/rela. brd4 is functionally required for expression of the nf-κb-dependent inflammatory gene regulatory network (grn), including the ifn response factor ... | 2017 | 28077651 |
| evaluation of alere i rsv for rapid detection of respiratory syncytial virus in children hospitalized with acute respiratory tract infection. | alere i rsv is a novel rapid test which applies a nicking enzyme amplification reaction to detect respiratory syncytial virus in point-of-care settings. in this study, we evaluated the alere i rsv assay by using frozen nasopharyngeal swab samples that were collected in viral transport medium from children hospitalized with acute respiratory tract infection during the 2015-2016 winter season. alere i rsv assay results were compared to those for altona realstar rsv real-time reverse transcription- ... | 2017 | 28077700 |
| respiratory syncytial virus associated hospitalizations in preterm infants of 29 to 32 weeks gestational age using a risk score tool for palivizumab prophylaxis. | to evaluate the efficacy of palivizumab in infants of 29 to 32 weeks of gestational age (ga) based on a risk score tool developed for austria. retrospective single-center cohort study including all preterm infants of 29 (+0) to 32 (+6) weeks of ga born between 2004 and 2012 at a tertiary care university hospital. data on rsv-related hospitalizations over the first 2 years of life were analyzed and compared between those having received palivizumab and those without. the study population was comp ... | 2017 | 28078558 |
| [differential diagnosis of the viral etiology of suspected mumps in a population with high vaccine coverage]. | in this study, buccal swabs from patients with the clinical picture of parotitis epidemica in whom mumps virus (mv) infection was not confirmed by direct detection or serologically were tested. the aim was to detect by molecular methods nucleic acids (nas) of other respiratory viruses possibly involved in salivary gland swelling. at the same time, paired sera, if available, were tested. | 2016 | 28078898 |
| modulation of antiviral immunity by heme oxygenase-1. | heme oxygenase-1 (ho-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. under several stress stimuli, ho-1 expression and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into carbon monoxide, free iron, and biliverdin. besides its effects on cell metabolism, ho-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity ... | 2017 | 28082120 |
| respiratory syncytial virus bronchiolitis in children. | bronchiolitis is a common lower respiratory tract infection in infants and young children, and respiratory syncytial virus (rsv) is the most common cause of this infection. rsv is transmitted through contact with respiratory droplets either directly from an infected person or self-inoculation by contaminated secretions on surfaces. patients with rsv bronchiolitis usually present with two to four days of upper respiratory tract symptoms such as fever, rhinorrhea, and congestion, followed by lower ... | 2017 | 28084708 |
| respiratory syncytial virus infection. | 2017 | 28084715 | |
| hospitalizations for respiratory syncytial virus and vaccine-preventable infections in the first 2 years after pediatric liver transplant. | to examine in liver transplant recipients at centers participating in the pediatric health information system dataset the number of hospitalizations for respiratory syncytial virus (rsv) and vaccine-preventable infections (vpis) in the first 2 years after transplantation, morbidity and mortality associated with these hospitalizations, and costs associated with these hospitalizations. | 2017 | 28088400 |
| patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy. | disadvantaged urban children have high rates of allergic diseases and wheezing, which are diseases associated with type 2-biased immunity. | 2017 | 28089873 |
| the relationships between respiratory virus infection and aminotransferase in children. | we sought to examine the relationship between the clinical manifestations of nonspecific reactive hepatitis and respiratory virus infection in pediatric patients. | 2016 | 28090469 |
| rsv associated hospitalizations in children in karachi, pakistan: implications for vaccine prevention strategies. | major progress is being made in vaccines against respiratory syncytial virus (rsv), with multiple vaccine candidates currently in the clinical phase of development. making an investment case for public sector financing of rsv vaccine will require estimation of burden, cost-effectiveness, and impact. the aim of this study is to determine the proportion, age distribution and clinical spectrum of rsv associated hospitalizations in children in karachi, pakistan. a three years prospective study was c ... | 2017 | 28092107 |
| reverse-transcription loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus directly from nasopharyngeal swabs. | respiratory syncytial virus (rsv) is a common cause of lower respiratory tract infection in young infants and a major cause of nosocomial infection in pediatric care. currently available rsv point-of-care tests are of limited sensitivity and relatively expensive. we developed and evaluated a novel rsv rapid test for use at point-of-care, based on reverse-transcription loop-mediated isothermal amplification (rt-lamp) for direct testing of nasopharyngeal swab specimens. rt-lamp can detect rsv with ... | 2017 | 28093275 |
| comparing human metapneumovirus and respiratory syncytial virus: viral co-detections, genotypes and risk factors for severe disease. | it is unclarified as to whether viral co-detection and human metapneumovirus (hmpv) genotypes relate to clinical manifestations in children with hmpv and lower respiratory tract infection (lrti), and if the clinical course and risk factors for severe lrti differ between hmpv and respiratory syncytial virus (rsv). | 2017 | 28095451 |
| human quarantine: toward reducing infectious pressure on chimpanzees at the taï chimpanzee project, côte d'ivoire. | due to their genetic relatedness, great apes are highly susceptible to common human respiratory pathogens. although most respiratory pathogens, such as human respiratory syncytial virus (hrsv) and human metapneumovirus (hmpv), rarely cause severe disease in healthy human adults, they are associated with considerable morbidity and mortality in wild great apes habituated to humans for research or tourism. to prevent pathogen transmission, most great ape projects have established a set of hygiene m ... | 2017 | 28095600 |
| spread and evolution of respiratory syncytial virus a genotype on1, coastal kenya, 2010-2015. | in february 2012, the novel respiratory syncytial virus (rsv) group a, genotype on1, was detected in kilifi county, coastal kenya. on1 is characterized by a 72-nt duplication within the highly variable g gene (encoding the immunogenic attachment surface protein). cases were diagnosed through surveillance of pneumonia in children at the county hospital. analysis of epidemiologic, clinical, and sequence data of rsv-a viruses detected over 5 rsv seasons (2010/2011 to 2014/2015) indicated the follow ... | 2017 | 28098528 |
| disease complexity in a declining alaskan muskox (ovibos moschatus) population. | the muskox ( ovibos moschatus ) population inhabiting the eastern north slope (ens) of alaska, us declined dramatically during 1999-2006, whereas populations in western alaska (wa) were stable or increasing. to understand morbidity and mortality factors contributing to the decline, alaska department of fish and game conducted pathologic investigations of carcasses from 2005 until 2008. additionally, archived sera from both ens and wa muskoxen collected during 1984-92, before the documented begin ... | 2017 | 28099077 |
| rage deficiency predisposes mice to virus-induced paucigranulocytic asthma. | asthma is a chronic inflammatory disease. although many patients with asthma develop type-2 dominated eosinophilic inflammation, a number of individuals develop paucigranulocytic asthma, which occurs in the absence of eosinophilia or neutrophilia. the aetiology of paucigranulocytic asthma is unknown. however, both respiratory syncytial virus (rsv) infection and mutations in the receptor for advanced glycation endproducts (rage) are risk factors for asthma development. here, we show that rage def ... | 2017 | 28099113 |
| activation pathway of a nucleoside analog inhibiting respiratory syncytial virus polymerase. | human respiratory syncytial virus (rsv) is a negative-sense rna virus and a significant cause of respiratory infection in infants and the elderly. no effective vaccines or antiviral therapies are available for the treatment of rsv. als-8176 is a first-in-class nucleoside prodrug inhibitor of rsv replication currently under clinical evaluation. als-8112, the parent molecule of als-8176, undergoes intracellular phosphorylation, yielding the active 5'-triphosphate metabolite. the host kinases respo ... | 2017 | 28103684 |
| [prediction of severe course in infants with rsv bronchiolitis under 6 months. spain]. | the need for mechanical ventilation (mv) in acute bronchiolitis (ab) by respiratory syncytial virus (rsv) varies depending on the series (6-18%). our goal is to determine the admissions to picu for mv in patients under 6 months with ab and define the risk factors for building a prediction model. | 2017 | 28104904 |
| respiratory syncytial virus infection: an innate perspective. | respiratory syncytial virus (rsv) is a common cause of upper respiratory tract infection in children and adults. however, infection with this virus sometimes leads to severe lower respiratory disease and is the major cause of infant hospitalisations in the developed world. several risk factors such as baby prematurity and congenital heart disease are known to predispose towards severe disease but previously healthy, full-term infants can also develop bronchiolitis and viral pneumonia during rsv ... | 2016 | 28105323 |
| first versus second year respiratory syncytial virus prophylaxis in chronic lung disease (2005-2015). | children aged <2 years with chronic lung disease (cld) have a 10-fold higher risk for respiratory syncytial virus-positive hospitalization (rsvh) compared to healthy term infants. based on the updated position statements, we compared respiratory-related illness hospitalization (rih) and rsvh risks in cld children who received palivizumab during the first year (fy) versus second year (sy) of life in the canadian registry of palivizumab (caress). demographic data were collected at enrolment and ri ... | 2017 | 28105526 |
| recent sequence variation in probe binding site affected detection of respiratory syncytial virus group b by real-time rt-pcr. | direct immuno-fluorescence test (ifat) and multiplex real-time rt-pcr have been central to rsv diagnosis in kilifi, kenya. recently, these two methods showed discrepancies with an increasing number of pcr undetectable rsv-b viruses. | 2017 | 28107671 |
| neutrophil subset responses in infants with severe viral respiratory infection. | neutrophils are the predominant inflammatory cells recruited to the respiratory tract as part of the innate immune response to viral infections. recent reports indicate the existence of distinct functional neutrophil subsets in the circulatory compartment of adults, following severe inflammatory conditions. here, we evaluated the occurrence of neutrophil subsets in blood and broncho-alveolar lavage fluid during severe viral respiratory infection in infants based on cd16/cd62l expression. we show ... | 2017 | 28108365 |
| age-specific profiles of antibody responses against respiratory syncytial virus infection. | respiratory syncytial virus (rsv) is one of the most prevalent causative agents of lower respiratory tract infections worldwide, especially in infants around 3 to 4months old. infants at such a young age have maternally-transferred passive antibodies against rsv but do not have active immune systems efficient enough for the control of rsv infection. in order to elucidate age-specific profiles of immune responses against rsv protection, antibody responses were examined by using blood samples in b ... | 2017 | 28111238 |
| rapid profiling of rsv antibody repertoires from the memory b cells of naturally infected adult donors. | respiratory syncytial virus (rsv) causes substantial morbidity and mortality in young children and the elderly. there are currently no licensed rsv vaccines, and passive prophylaxis with the monoclonal antibody palivizumab is restricted to high-risk infants in part due to its modest efficacy. although it is widely agreed that an effective rsv vaccine will require the induction of a potent neutralizing antibody response against the rsv fusion (f) glycoprotein, little is known about the specificit ... | 2016 | 28111638 |
| [potential neurocognitive consequences of infection by human respiratory syncytial virus]. | human respiratory syncytial virus (rsv) infection remains as a major cause of morbidity and mortality among pediatric population. immune response is poor and unable to establish a long term effective protection against this virus. of particular interest has been the description of extrapulmonary manifestations of rsv infection in liver, kidney, endocrine system, heart and brain, associated to infection of peripheral blood. in the central nervous system (cns), recent studies in animals have sugge ... | 2016 | 28112337 |
| impact of viral respiratory pathogens on outcomes after pediatric cardiac surgery. | viral respiratory infection is commonly considered a relative contraindication to elective cardiac surgery. we aimed to determine the frequency and outcomes of symptomatic viral respiratory infection in pediatric cardiac surgical patients. | 2017 | 28114162 |
| in vitro screening for antiviral activity of turkish plants revealing methanolic extract of rindera lanata var. lanata active against human rotavirus. | human rotavirus (hrov) is the leading cause of severe gastroenteritis in infants and children under the age of five years. no specific antiviral drug is available for hrov infections and the treatment of viral diarrhea is mainly based on rehydration and zinc treatment. in this study, we explored medicinal plants endemic to turkey flora as a source of anti-hrov compunds. | 2017 | 28118832 |
| use of an automated nested multiplex respiratory pathogen pcr panel postmortem in the pediatric forensic setting. | respiratory pathogens have been detected in forensic investigations using multiple techniques; however, no study has examined the use of automated, nested, multiplex polymerase chain reaction (anm-pcr), commonly used in living patients, in the forensic setting. this retrospective study assessed the utility of anm-pcr in detecting respiratory pathogens in the pediatric forensic setting. respiratory samples from 35 cases were tested for up to 20 respiratory pathogens. 51.4% of these cases yielded ... | 2017 | 28120330 |
| lower respiratory tract diseases caused by common respiratory viruses among stem cell transplantation recipients: a single center experience in korea. | to describe the incidence, clinical courses, and risk factors for mortality of lower respiratory tract diseases (lrds) caused by common respiratory viruses (crvs) in stem cell transplantation (sct) recipients. | 2017 | 28120567 |
| correlation of symptomatic enterovirus infection and later risk of allergic diseases via a population-based cohort study. | infants who are exposed to the rhinovirus or respiratory syncytial virus are at a higher risk of subsequently developing wheezing or asthma. this study aims to determine whether preschoolers with a history of symptomatic enterovirus infection are at an increased risk of developing allergic diseases or not.we used data from the taiwan national health insurance research database from 1999 to 2006 for this nationwide population-based cohort study. the subsequent risks for allergic diseases, which i ... | 2017 | 28121929 |
| matrix metalloproteinase 9 facilitates hepatitis b virus replication through binding with type i interferon (ifn) receptor 1 to repress ifn/jak/stat signaling. | hepatitis b virus (hbv) infection may cause acute hepatitis b, chronic hepatitis b (chb), liver cirrhosis, and hepatocellular carcinoma (hcc). however, the mechanisms by which hbv evades host immunity and maintains chronic infection are largely unknown. here, we revealed that matrix metalloproteinase 9 (mmp-9) is activated in peripheral blood mononuclear cells (pbmcs) of hbv-infected patients, and hbv stimulates mmp-9 expression in macrophages and pbmcs isolated from healthy individuals. mmp-9 p ... | 2017 | 28122987 |
| high flow nasal cannula (hfnc) versus nasal continuous positive airway pressure (ncpap) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (tramontane study). | nasal continuous positive airway pressure (ncpap) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (avb). although oxygen delivery via high flow nasal cannula (hfnc) is increasingly used, evidence of its efficacy and safety is lacking in infants. | 2017 | 28124736 |
| [a case of bronchiolitis obliterans secondary to human metapneumovirus bronchiolitis]. | human metapneumovirus (hmpv), formerly classified in paramyxoviridae family is now moved into pneumoviridae, which was described as a novel family. it causes upper and lower respiratory tract infections (lrtis) usually in children younger than five years old. the recent epidemiological studies indicated that hmpv is the second most frequently detected virus in lrtis of young children, following the respiratory syncytial virus (rsv). bronchiolitis obliterans (bo) is a chronic obstructive lung dis ... | 2016 | 28124966 |
| educating parents about the vaccination status of their children: a user-centered mobile application. | parents are often uncertain about the vaccination status of their children. in times of vaccine hesitancy, vaccination programs could benefit from active patient participation. the vaccination app (vaccapp) was developed by the vienna vaccine safety initiative, enabling parents to learn about the vaccination status of their children, including 25 different routine, special indication and travel vaccines listed in the who immunization certificate of vaccination (who-icv). between 2012 and 2014, t ... | 2017 | 28127527 |
| virus-like particle vaccines containing f or f and g proteins confer protection against respiratory syncytial virus without pulmonary inflammation in cotton rats. | vaccine-enhanced disease has been a major obstacle in developing a safe vaccine against respiratory syncytial virus (rsv). this study demonstrates the immunogenicity, efficacy, and safety of virus-like particle (vlp) vaccines containing rsv f (f vlp), g (g vlp), or f and g proteins (fg vlp) in cotton rats. rsv specific antibodies were effectively induced by vaccination of cotton rats with f vlp or fg vlp vaccines. after challenge, lung rsv clearance was observed with rsv f, g, fg vlp, and formal ... | 2017 | 28129031 |
| viral encephalitis after haplo-identical hematopoietic stem cell transplantation: causative viral spectrum, characteristics, and risk factors. | to retrospectively identify characteristics and risk factors of viral encephalitis (ve) in patients who underwent a haplo-identical hematopoietic stem cell transplant (hsct). | 2017 | 28129450 |
| viral influenza-like illnesses: dynamic interrelationships during the 2015-2016 influenza season in hospitalized patients. | in hospitalized children and adults, the temporal relationship of viruses causing influenza-like illnesses (ilis) and influenza has not been well described. during the 2015-2016 influenza season at our hospital, the dynamic interrelationships between ili viruses (human metapneumovirus, respiratory syncytial virus, human parainfluenza viruses 3 and 4, rhinoviruses/enteroviruses, and coronaviruses) and influenza a were characterized in 768 hospitalized children and adults. | 2017 | 28131642 |
| microrna-146a induction during influenza h3n2 virus infection targets and regulates traf6 levels in human nasal epithelial cells (hnecs). | we have previously shown that human nasal epithelial cells (hnecs) are highly permissive cells for respiratory viruses including influenza a virus (iav) and respiratory syncytial virus. recent studies have indicated that micrornas (mirnas) are involved in virus-host relationship, and this led us to investigate its essential roles in the in vitro hnecs model derived from multiple donors. by comparing the differential expression of mirnas upon iav infection among animal and cell line studies, cand ... | 2017 | 28131813 |
| the diagnosis and management of respiratory viral infections in cystic fibrosis. | respiratory viruses, such as those that cause influenza and the common cold, are a regular feature of life for the entire human population. among people with cf, these viruses are associated with prolonged respiratory illness and show a clear association with pulmonary exacerbations which in turn are associated with lung function decline and risk of death. human rhinovirus is the most commonly encountered respiratory viral pathogen in cf although adenovirus, bocavirus, coronavirus, influenza, pa ... | 2017 | 28132571 |
| structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus. | respiratory syncytial virus (rsv) and human metapneumovirus (hmpv) are two closely related viruses that cause bronchiolitis and pneumonia in infants and the elderly(1), with a significant health burden(2-6). there are no licensed vaccines or small-molecule antiviral treatments specific to these two viruses at present. a humanized murine monoclonal antibody (palivizumab) is approved to treat high-risk infants for rsv infection(7,8), but other treatments, as well as vaccines, for both viruses are ... | 2017 | 28134915 |
| a novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein. | respiratory syncytial virus (rsv) remains a major human pathogen, infecting the majority of infants before age two and causing re-infection throughout life. despite decades of rsv research, there is no licensed rsv vaccine. most candidate vaccines studied to date have incorporated the rsv fusion (f) surface glycoprotein, because the sequence of f is highly conserved among strains of rsv. to better define the human b cell response to rsv f, we isolated from a single donor 13 new neutralizing huma ... | 2017 | 28134924 |
| characteristics of rsv-specific maternal antibodies in plasma of hospitalized, acute rsv patients under three months of age. | respiratory syncytial virus (rsv) is the leading cause for respiratory illness that requires hospitalization in infancy. high levels of maternal antibodies can protect against rsv infection. however, rsv-infected infants can suffer from severe disease symptoms even in the presence of high levels of rsv-specific antibodies. this study analyzes several serological characteristics to explore potential deficiencies or surpluses of antibodies that could relate to severe disease symptoms. we compare s ... | 2017 | 28135305 |
| a short double-stapled peptide inhibits respiratory syncytial virus entry and spreading. | synthetic peptides derived from the heptad repeat (hr) of fusion (f) proteins can be used as dominant negative inhibitors to inhibit the fusion mechanism of class i viral f proteins. here, we have performed a stapled-peptide scan across the hr2 domain of the respiratory syncytial virus (rsv) f protein with the aim to identify a minimal domain capable of disrupting the formation of the postfusion six-helix bundle required for viral cell entry. constraining the peptides with a single staple was no ... | 2017 | 28137809 |
| respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (aecopd) cause significant morbidity, mortality, and an inexorable decline of lung function. data from developed countries have shown viruses to be important causes of aecopd, but data from developing countries like india are scant. we set out to determine the contribution of viruses in the causation of hospitalized patients with aecopd. | 2017 | 28144057 |
| immunization with low doses of recombinant postfusion or prefusion respiratory syncytial virus f primes for vaccine-enhanced disease in the cotton rat model independently of the presence of a th1-biasing (gla-se) or th2-biasing (alum) adjuvant. | respiratory syncytial virus (rsv) infection of children previously immunized with a nonlive, formalin-inactivated (fi)-rsv vaccine has been associated with serious enhanced respiratory disease (erd). consequently, detailed studies of potential erd are a critical step in the development of nonlive rsv vaccines targeting rsv-naive children and infants. the fusion glycoprotein (f) of rsv in either its postfusion (post-f) or prefusion (pre-f) conformation is a target for neutralizing antibodies and ... | 2017 | 28148790 |
| virus vs. virus: adenovirus vectored vaccine to defeat respiratory syncytial virus. | 2016 | 28149851 | |
| palivizumab prophylaxis in preterm infants and subsequent recurrent wheezing. six-year follow-up study. | respiratory syncytial virus (rsv) induces not only infantile recurrent wheezing but also potentially atopic asthma. | 2017 | 28152315 |