Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| host-cell repair of vaccinia virus and of double stranded rna of encephalomyocarditis virus. | 1971 | 4328801 | |
| synthesis of capsid and noncapsid viral proteins in response to encephalomyocarditis virus ribonucleic acid in animal cell-free systems. | the polypeptide products formed in two cell-free protein-synthetic systems programmed with encephalomyocarditis (emc) virus ribonucleic acid (rna) have been compared with the virus-specific proteins found in emc-infected cells and with the capsid proteins of the purified virion. tryptic peptides of (35)s-methioninelabeled proteins from these three sources were compared by co-chromatography and electrophoresis and by isoelectric focussing. fifty-two methionine-containing peptides were resolved in ... | 1971 | 4331652 |
| protein synthesis directed by encephalomyocarditis virus rna: properties of a transfer rna-dependent system. | small amounts of encephalomyocarditis virus rna direct a 50-fold increase in amino acid incorporation, in appropriately supplemented ascites tumor cell extracts, under conditions that give rise to authentic viral polypeptides. incorporation in these crude extracts has a novel characteristic, namely, that it is almost entirely dependent upon the addition of exogenous trna. further, this incorporation is restricted in that trna derived from ascites tumor cells or from rat liver permits translation ... | 1971 | 4332253 |
| early myocardial lesions in encephalomyocarditis (emc) virus infected mice. | 1971 | 4334293 | |
| mural and valvular endocarditis of mice infected with encephalomyocarditis (emc) virus. | 1971 | 4336178 | |
| studies of the protein subunit of ph-inactivated mengo virus variants. ii. physicochemical properties. | 1971 | 4330368 | |
| interferon-inducing characteristics of mm virus. | interferon induction by mm virus in mice and in l cells was studied. in mice the virus readily induced interferon. the time of appearance was dose-dependent. a large virus dose induced interferon by 4 hr, whereas a small dose resulted in interferon production which paralleled virus replication 24 hr after infection. in l cells the interferon-inducing capacity of the virus was rapidly destroyed by ultraviolet light irradiation. heating (56 c) of the virus, on the other hand, greatly increased its ... | 1971 | 4324191 |
| [virus induced diabetes mellitus in the white mouse]. | 1971 | 4325206 | |
| protein synthesis in cell-free systems: an effect of interferon. | the activity of ribosome and cell-sap fractions from interferon-treated and control chick embryo fibroblasts was compared in mixed chick-mouse and purely chick cell-free systems capable of the synthesis of viral polypeptide(s) in response to viral ribonucleic acid (rna). interferon treatment of cells did not affect the intrinsic amino acid incorporation activity of these systems or their response to polyuridylic acid. with encephalomyocarditis (emc) virus rna as messenger, however, a fraction of ... | 1971 | 4329562 |
| duration of resistance to viral infection following administration of interferon inducers. | 1971 | 4328255 | |
| virus protein synthesis in animal cell-free systems: nature of the products synthesized in resonse to ribonucleic acid of encephalomyocarditis virus. | ribonucleic acid (rna) from encephalomyocarditis (emc) virus stimulates the incorporation of amino acids into protein in cell-free protein-synthetic systems derived from krebs mouse ascites tumor cells and chick embryo fibroblasts; the mouse system is the more responsive to the viral rna. the greater part of this difference in activity can be ascribed to the cell sap, but the origin of the ribosomes also has a marked effect. the nature of the polypeptides formed in these cell-free systems was in ... | 1971 | 4329561 |
| diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. | 1971 | 4323473 | |
| [inhibition by pironine of rna virus multiplication]. | 1971 | 4327064 | |
| serologic evidence of arbovirus activity in a moose population in alberta. | 1971 | 4361127 | |
| effects of phenylalanine analogues on virus multiplication and protein synthesis in a cell-free system. | 1971 | 4397338 | |
| [synthesis of virus-specific proteins in cells infected by the encephalomyocarditis virus]. | 1971 | 5103259 | |
| effect of cyclophosphamide on the protective action of endotoxin in mice challenged with encephalomyocarditis virus. | 1972 | 4402249 | |
| enhancement of interferon production by lowered temperature and-or cyclohexximide in endotoxin-stimulated mouse leukocytes. | 1972 | 4402251 | |
| distribution of antiviral and cell-inhibitory activity in interferon preparations. | 1972 | 4403180 | |
| effect of nembutal on uninfected and encephalomyocarditis virus-infected krebs-ii carcinoma cells. | 1972 | 4404100 | |
| evaluation of the czechoslovak double-stranded rna preparation as inducer of interferon in model experiments. | 1972 | 4404898 | |
| interaction between encephalomyocarditis (emc) virus and polio-virus in cultured cells. increase in the number of emc virus-producing cells. | 1972 | 4401077 | |
| differentiated change in polyribosome and free ribosome density with an increase in ionic strength. | 1972 | 4343833 | |
| mechanism of interferon action: inhibition of viral messenger ribonucleic acid translation in l-cell extracts. | encephalomyocarditis (emc) virus ribonucleic acid (rna) stimulated the incorporation of (14)c-amino acids into polypeptides in cell-free systems using preincubated s10 extracts from l cells. incorporation was linear for over 2 hr. analysis of the tryptic peptides derived from the polypeptide products formed in response to emc rna showed them to be virus specific. the major product, a polypeptide of 140,000 in molecular weight, migrated on sodium dodecyl sulfate-polyacrylamide gels with one of th ... | 1972 | 4345494 |
| [pathology of diabetes mellitus in the white mouse infected with emc-virus. histological, electronmicroscopical and quantitative morphological findings in the islets of langerhans]. | 1972 | 4341575 | |
| capsid polypeptides of mouse elberfeld virus. i. amino acid compositions and molar ratios in the virion. | the four major polypeptide chains (alpha, beta, gamma, delta) constituting the capsid protein of mouse elberfeld (me) virus were isolated by preparative electrophoresis on polyacrylamide gels, and the amino acid composition of each chain was determined. in addition, the molecular weights of the smallest chains of me virus, mengovirus, and poliovirus, which had previously been determined by gel electrophoretic methods, were redetermined by gel filtration chromatography in 6 m guanidine hydrochlor ... | 1972 | 4342047 |
| effect of vesicular stomatitis virus infection on the histocompatibility antigen of l cells. | when mouse l cells are infected for 22 hr with vesicular stomatitis virus (vsv), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (h-2), is no longer detectable by the method of inhibition of immune cytolysis. infected cells prelabeled with (14)c-glucosamine also show a correspondingly greater loss of trichloroacetic acid-insoluble radioactivity than uninfected cells. the loss of h-2 antigenic activity is not due to the viral inhibition of h ... | 1972 | 4343540 |
| murine resistance to inhaled neisseria meningitidis after infection with an encephalomyocarditis virus. | a reduction in pulmonary anti-bacterial activity due to a preceding viral illness has been suggested as the mechanism responsible for some meningococcal infections of the lung. we investigated this proposed pathogenesis by infecting mice with airborne encephalomyocarditis virus (emc) and then challenging them 1, 4, and 7 days later with aerosols of neisseria meningitidis. meningococcal clearance was assessed by comparing the numbers of bacteria present immediately after inhaling the aerosols wit ... | 1972 | 4344397 |
| effects of arsenicals on interferon formation and action. | 1972 | 4345020 | |
| initiation of picornavirus protein synthesis in ascites cell extracts. | the current model of picornavirus protein formation implies that initiation of protein synthesis occurs at a single site on the viral rna, and that the large polypeptide formed is later cleaved. a direct test of this model was made in vitro by studying the incorporation of [(35)s]methionine from rabbit liver met-trna(m) (met) and fmet-trna(f) (met) into encephalomyocarditis virus rna-coded proteins in extracts of ehrlich ascites cells. the incorporation of n-formylmethionine was complete within ... | 1972 | 4345505 |
| correlation of messenger rna function with adenylate-rich segments in the genomes of single-stranded rna viruses. | oligonucleotides enriched in adenylate residues have been demonstrated in the genomes of two positive-strand rna viruses, sindbis and columbia sk. such oligonucleotides were not found in the genome of vesicular stomatitis virus, a negative-strand virus. the adenylate-rich oligonucleotides from sindbis and columbia sk viruses appeared similar when analyzed by zonal sedimentation in sucrose-sodium dodecyl sulfate. | 1972 | 4338595 |
| differential inhibition of nuclear rna polymerases in l cells infected with mengovirus. | 1972 | 4338796 | |
| insulin and the regulation of protein synthesis in muscle. | 1972 | 4343351 | |
| immunization of mice against encephalomyocarditis virus. i. purification, concentration, and inactivation of encephalomyocarditis virus. | methods are described for the concentration, purification, and inactivation of encephalomyocarditis virus grown in l-cell suspension cultures. virus concentrates were obtained by the precipitation of crude virus lysates with polyethylene glycol and were purified by genetron extraction. after column chromatography approximately 70% recovery of infectivity and hemagglutination (ha) activity was found. exposure of the purified virus suspensions to ultraviolet light resulted in reduction of the infe ... | 1972 | 4344026 |
| isolation and subunit structure of polycytidylate-dependent rna polymerase of encephalomyocarditis virus. | a polycytidylate-dependent rna polymerase of encephalomyocarditis virus was isolated from infected bhk 21 cells. the enzyme was associated with a smooth-membrane fraction, from which it was extracted by a mixture of sodium dodecyl sulfate, triton x-100, and dithiothreitol, and further purified by chromatography on a dowex-1 column and by glycerol gradient sedimentation. analysis of a 6s glycerol gradient peak of rna polymerase activity by sodium dodecyl sulfate-polyacrylamide gel electrophoresis ... | 1972 | 4345509 |
| the effect of priming with interferon on interferon production by two lines of l cells. | 1972 | 4337220 | |
| antiviral activity and side effects of polyriboinosinic-cytidylic acid complexes as affected by molecular size. | the decrease of the molecular size of poly(i.c) to less than 10(6) decreases its ability to induce interferon, protect mice against virus, or enhance the immune response. immune adjuvant activity appeared more sensitive to molecular weight than the other protective activities. the composition of the complex-the molecular size of the individual homopolymers when one was large and the other small-did not affect antiviral activity; the activity of a complex made from large poly(i) and small poly(c) ... | 1972 | 4337241 |
| biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls. | whole mycobacterial cells, which are used in freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. the data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells. | 1972 | 4337242 |
| distribution of initiation factors in cell fractions from mammalian tissues. | 1972 | 4331124 | |
| an automatic high-precision acrylamide gel fractionator. | 1972 | 4338614 | |
| [isolation of "minus" chain of ribonucleic acid of the murine encephalomyocarditis virus and study of its infectivity]. | 1972 | 4338671 | |
| nucleotide pools in novikoff rat hepatoma cells growing in suspension culture. 3. effects of nucleosides in medium on levels of nucleotides in separate nucleotide pools for nuclear and cytoplasmic rna synthesis. | this study was undertaken to measure the absolute levels of nucleoside pools in novikoff rat hepatoma cells (subline n1s1-67) during growth in suspension culture in the presence of high concentrations of various nucleosides in the medium, and to obtain further evidence for the compartmentalization of the nucleotides in independent cytoplasmic and nuclear pools. the levels of nucleotide pools were measured by growing the cells in medium supplemented with inorganic phosphate-(32)p. the nucleotide ... | 1972 | 4331295 |
| pancreatic islet cell damage in mice produced by coxsackie b 1 and encephalomyocarditis viruses. | 1972 | 4337357 | |
| the effect of certain amino acids on reproduction of encephalomyocarditis virus. i. investigation of the inhibiting effect of l-lysine. | 1972 | 4337543 | |
| immunization of mice against encephalomyocarditis virus. ii. intraperitoneal and respiratory immunization with ultraviolet-inactivated vaccine: effect of bordetella pertussis extract on the immune response. | mice were immunized by intraperitoneal (ip) or respiratory administration of ultraviolet-inactivated virus alone or with bordetella pertussis extract (bpe) as an adjuvant. the effect of immunization was tested by determination of antibody titers and by survival of a lethal challenge with 200 ld(50) of a virulent (large-plaque variant) strain of emc virus. for plain vaccine the ip 50% effective dose (ed(50)) was 37 hemagglutination units (hau; ca. 4 x 10(6) plaque-forming unit equivalents); with ... | 1972 | 4344027 |
| synthesis and cleavage of virus-specifici proteins in krebs ii carcinoma cells infected with encephalomyocarditis virus. | 1972 | 4344151 | |
| poly u tracts absent from viral rna. | 1972 | 4344177 | |
| kinetics of synthesis and cleavage of encephalomyocarditis virus-specific proteins. | 1972 | 4344195 | |
| virus-specific polypeptides in ascites cells infected with encephalomyocarditis virus. | 1972 | 4344313 | |
| hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents. | interferon inducers are generally most effective as antiviral agents when used prophylactically. one possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, tilorone hydrochloride, new-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a mode ... | 1972 | 4344367 |
| comparative studies of plaque variantes derived from a florida strain of venezuelan equine encephlomyelitis virus. | small- and large-plaque variants of a florida strain (fe 3-7c) of venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. the small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. the variants could be distinguished by calcium phosphate chromatography. the implications of plaque variants within a mixed virus population are discussed. | 1972 | 4344368 |
| differential susceptibility of male and female mice to encephalomyocarditis virus: effects of castration, adrenalectomy, and the administration of sex hormones. | male mice have been noted to be more susceptible to encephalomyocarditis (emc) virus than female animals. castration of male mice abolished this difference and resulted in enhanced resistance similar to that of female mice. this increase in resistance in castrated males could be eliminated by adrenalectomy. adrenalectomy alone increased susceptibility in male mice but not in female mice. the administration of a long-acting preparation of testosterone markedly increased susceptibility both in cas ... | 1972 | 4344392 |
| the early renal lesions of mice infected with encephalomyocarditis virus. | 1972 | 4333963 | |
| [action of rifampicin on the vesicular stomatitis virus]. | 1972 | 4335152 | |
| [relation between complementary chains in the molecules of the replicative form of encephalomyocarditis virus rna]. | 1972 | 4335155 | |
| increased mortality in encephalomyocarditis virus-infected mice consuming cobalt sulfate: tissue concentrations of cobalt. | 1972 | 4342332 | |
| effects of arsenicals on viral infections in mice. | 1972 | 4343075 | |
| further studies on the translation of globin mrna and encephalomyocarditis virus rna in a cell-free system from krebs ii ascites cells. | 1972 | 4339672 | |
| mouse leukemia: depression of serum interferon production. | production of circulating interferon is significantly impaired in akr/j mice after development of lymphoblastic leukemia and in balb/c mice with clinical signs of friend erythroblastic leukemia. this alteration has been observed with three interferon inducers, each one known to elicit an interferon response in different cells. | 1972 | 4340758 |
| in vitro translation of cardiovirus ribonucleic acid by mammalian cell-free extracts. | cell-free extracts prepared from ehrlich ascites and mouse l cells synthesize viral proteins in response to encephalomyocarditis virus, mouse elberfeld virus, and mengovirus ribonucleic acid. although hela cell extracts are inactive, their ribosomes are functional in the presence of heterologous supernatant fractions. synthesis depends upon the addition of adenosine triphosphate, guanosine triphosphate, an energy-generating system, and 4 mm mg(2+). initiation is completed during the first 10 to ... | 1972 | 4336562 |
| rna polymerase complexes from mengovirus infected cells. | 1972 | 4341300 | |
| study of the interaction of soluble and particle-bound nicotinamide adenine dinucleotide pyrophosphorylase with cytoplasmic ribosomes. | 1972 | 4337264 | |
| effects of sonication on physicochemical and biological properties of synthetic double-stranded polyribonucleotides as interferon inducer. | 1972 | 4352302 | |
| characterization of the polypeptides formed in response to encephalomyocarditis virus ribonucleic acid in a cell-free system from mouse ascites tumor cells. | the polypeptide products synthesized at different times in a cell-free system from krebs mouse ascites tumor cells in response to the addition of encephalomyocarditis (emc) virus ribonucleic acid (rna) were characterized by electrophoresis on polyacrylamide gels and fingerprint analysis of their tryptic peptides. translation of the emc rna genome with time occurred in a nonrandom fashion in these systems, to yield products containing sequences characteristic of both virion capsid polypeptides an ... | 1972 | 4339197 |
| the emc virus in valves of the heart. | 1972 | 4339455 | |
| isoprinosine: lack of antiviral activity in experimental model infections. | 1972 | 4340925 | |
| simple method for the isolation of encephalomyocarditis virus ribonucleic acid. | a simple purification procedure for encephalomyocarditis virus is described, yielding material suitable for extraction of viral ribonucleic acid for use as messenger in animal cell-free systems. | 1972 | 4335665 |
| isolation of the minus strand of encephalomyocarditis virus rna. | 1972 | 4337993 | |
| study of two double-stranded ribonucleic acids of viral origin: interferon inducing and antiviral activities. | 1972 | 4349828 | |
| protein synthesis directed by encephalomyocarditis virus mrna. 3. discrete polypeptides translated from a monocistronic messenger in vitro. | 1972 | 4350807 | |
| increased efficiency of exogenous messenger rna translation in a krebs ascites cell lysate. | addition of a 0.5 m kcl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mrnas by krebs-cell lysates. in the presence of the wash fraction, 1 pmol of rabbit or mouse 10s rna directs the incorporation of 80 pmol of leucine into rabbit globin. the addition of human 10s rna results in the synthesis of equal amounts of human alpha and beta chains, identified by column chromatography. the stimulation by the wash fraction is almos ... | 1972 | 4338590 |
| [effect of 2-(alpha-hydroxybenzyl)-benzimidazole and guanidine on the activity of rna polymerases, induced by encephalomyocarditis viruses and poliovirus]. | 1972 | 4343925 | |
| a model for foot-and-mouth disease virus. | 1972 | 4338333 | |
| translation of encephalomyocarditis viral rna in oocytes of xenopus laevis. | rna from encephalomyocarditis virus was injected into oocytes of xenopus laevis. after incubation of the oocytes in [(35)s]methionine, polyacrylamide gel electrophoresis showed that a new series of polypeptides had been synthesized. they were identical in size to the polypeptides that appeared in ascites cells after infection with this virus. electrophoretic and chromatographic analysis of the methionine-containing tryptic peptides from three of the induced polypeptides confirmed that they were ... | 1972 | 4345506 |
| gene order of encephalomyocarditis virus as determined by studies with pactamycin. | previous work has shown that translation of the encephalomyocarditis (emc) viral ribonucleic acid (rna) generates at least three primary products, polypeptides a, f, and c. the a and c polypeptides then undergo post-translational cleavages to complete the production of the stable viral polypeptides (delta, beta, gamma, alpha, g, i, f, h, and e). in this communication we show that a, f, and c are produced in equimolar amounts giving further support to the theory that the rna of picornaviruses has ... | 1972 | 4337167 |
| workshop on viral infection and diabetes mellitus in man. | 1972 | 4336861 | |
| stimulation by reticulocyte initiation factors of protein synthesis in a cell-free system from krebs ii ascites cells. | 1972 | 4347125 | |
| circularity and cross-linking in preparations of replicative form of encephalomyocarditis virus rna. | 1972 | 4346099 | |
| proteinase activity in purified animal viruses. | 1972 | 4333423 | |
| 7-deazanebularin. metabolism in cultures of mouse fibroblasts and incorporation into cellular and viral nucleic acids. | 1972 | 4333510 | |
| rate of dna chain growth in mammalian cells infected with cytocidal rna viruses. | 1972 | 4333734 | |
| stimulation of restricted reproduction of emc virus in hela cells by non-replicating poliovirus. | 1973 | 4119353 | |
| neutralization of infectious me (maus-elberfeld) virus-antibody complexes by anti-gamma-globulin antibody. | 1973 | 4129412 | |
| viral encephalitis. | 1973 | 4144386 | |
| interferon tolerance and antiviral protection in mice given single or multiple injections of endotoxin or poly i : c. | 1973 | 4147139 | |
| interferon induction by detoxicated bacterial endotoxins. | 1973 | 4150031 | |
| changes in isoelectric points of chromatin deoxyribonucleoproteins from krebs ii cells after infection with encephalomyocarditis virus. | 1973 | 4150035 | |
| picornaviral gene order: comparison of a rhinovirus with a cardiovirus. | we describe conditions for unmasking virus-specific protein synthesis in cells infected with rhinoviruses 1a and 2. the gene order and cleavage pattern of rhinovirus 1a show many similarities to those of encephalomyocarditis virus and of poliovirus. | 1973 | 4347432 |
| ultrastructural cytopathology of mouse myocardium associated with emc viral infection. | 1973 | 4348560 | |
| enhancement of interferon production of murine peritoneal leukocytes by mineral oil: the effect of experimental emc infection in mice. | 1973 | 4349471 | |
| purification of a messenger-specific initiation factor from ascites-cell supernatant. | 1973 | 4351524 | |
| a physico-chemical sub-grouping of the mammalian picornaviruses. | 1973 | 4351695 | |
| lesions of renal glomeruli in mice with virus-induced diabetes mellitus-like disease. | 1973 | 4351966 | |
| specificity of the control of protein synthesis by haemin. | 1973 | 4351984 | |
| function of phosphorylated ribosomes. the activity of ribosomal subunits phosphorylated in vitro by protein kinase. | 1973 | 4352193 | |
| [detection of complement fixing antibodies against herpes simplex virus (and other neurotropic viruses) in patients with multiple sclerosis]. | 1973 | 4350584 | |
| antiviral activity of isoprinosine in vitro and in vivo. | 1973 | 4350802 | |
| encephalomyocarditis (emc) virus infection of the mouse aorta. an ultrastructural study. | 1973 | 4355169 | |
| propionin b, an antiviral principle of propionibacteria. | 1973 | 4355824 | |
| mechanism of interferon uptake in parental and somatic monkey-mouse hybrid cells. | dose-response curves of interferons in different sensitive cells are regularly sigmoidal. in somatic monkey-mouse hybrid cells, however, a significant decrease in the slope of the curve for primate interferon was observed, while the dose-response effect was unaltered for mouse interferon. high concentrations of primate interferon were 10- to 100-times less effective in hybrid clones than in parental monkey cv-1 cells; at low concentrations the antiviral effect was 10- to 20-times higher in hybri ... | 1973 | 4346894 |