Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| stimulatory and inhibitory effects of adenovirus and sv40 on various virus-cell systems. | 1970 | 4318579 | |
| distribution of cell receptors and simple sugar inhibitors during encephalomyocarditis virus-cell union. | encephalomyocarditis (emc) virus was studied for ability to agglutinate erythrocytes of various species. human, rat, and guinea pig erythrocytes, as well as those from young rabbits, were readily agglutinated. cells from older rabbits absorbed virus poorly, and showed little agglutination. uptake of virus by rabbit brain also diminished with age. various mouse tissues absorbed virus about equally well. hemagglutination-inhibition studies demonstrated that a number of simple sugars, particularly ... | 1967 | 4318947 |
| separation of plaque-type variants of encephalomyocarditis virus by chromatography on calcium phosphate. | encephalomyocarditis (emc) virus (k-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. the virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopic appearance, sedimentation coefficient, or base ratios. however, variants producing large plaques predominated in the first peak eluted, whereas variants producing small plaques we ... | 1967 | 4318950 |
| interaction of encephalomyocarditis virus with ultraviolet-irradiated host cells. | ultraviolet light (uv) impaired the capacity of l cells to support growth of encephalomyocarditis virus. the loss of capacity was partially restored by high multiplicity of infection (moi). this phenomenon was not due to an increased probability of an infectious virus particle reaching a site of replication undamaged by uv, since uv-inactivated virus at high moi induced restoration of the capacity to support multiplication of nonirradiated virus adsorbed at low moi. multiplicity reactivation of ... | 1967 | 4318958 |
| studies of the protein subunit of ph-inactivated mengo virus variants. i. polypeptide composition. | 1970 | 4318981 | |
| mengovirus rna synthesis in productive and restrictive cell lines. | 1970 | 4318986 | |
| influence of blood clearance rates on interferon production and virulence of mengo virus plaque mutants in mice. | 1970 | 4319089 | |
| experimental encephalomyocarditis virus infection in calves. | 1970 | 4319465 | |
| transfer of interferon-producing macrophages: new approach to viral chemotherapy. | mice were protected from infection with semliki forest virus and encephalomyocarditis virus by the transfer of peritoneal macrophages that were stimulated to produce interferon in vitro by exposure to a nonreplicating virus. this method of therapy was also utilized in animals infected with encephalomy-ocarditis virus after onset of clinical signs. of these animals 40 percent recovered, but only 9 percent of the control group recovered. | 1970 | 4319682 |
| tissue-specific factor required for the translation of a mammalian viral rna. | 1970 | 4319843 | |
| [attempts to use the interference phenomenon for detecting several mice leukemia viruses in tissue culture]. | 1969 | 4320252 | |
| [some properties of the replicative form of mouse encephalomyocarditis virus rna]. | 1969 | 4320269 | |
| viral interference in the brains of mice infected subcutaneously with herpes simplex virus. | 1970 | 4320341 | |
| comparison of agar and agarose preparations for mengovirus plaque formation. | an agarose overlay yielded mengovirus plaques earlier and in greater size and number than overlays of chemically undefined agars with or without enhancers. marked variability in plaque-forming efficacy of commercial agarose preparations was noted. | 1970 | 4320349 |
| [relations between rna molecular structure and their induction power on interferon]. | 1970 | 4320457 | |
| growth of mouse l cells in shaken culture and mengovirus plaque formation on l cells suspended in agar. | procedures are described that require a minimum of equipment and maintenance for growing mouse l cells suspended in liquid medium and for plaquing mengovirus on l cells suspended in agar. viability of l cells during storage for 1 to 2 hr at relatively high concentrations was better in media at 30 c than at 0 c, as measured by viable counts after growth for 24 hr at 35 c. the number and size of plaques increased with increasing concentration of nahco(3) in the agar layers, but the relative differ ... | 1970 | 4320864 |
| rapid sensitive assay for interferons based on the inhibition of mm virus nucleic acid synthesis. | a method for assaying mouse interferon based on the inhibition of viral ribonucleic acid (rna) synthesis was devised. the amount of mm virus and rna synthesized in interferon-treated l-cell cultures was determined by measuring the amount of (3)h-uridine converted into a trichloroacetic acid-insoluble form after treatment of the infected cultures with 2.5 mug of actinomycin d per ml. the amount of rna synthesized was inversely related to the concentration of interferon used for treatment. a linea ... | 1970 | 4320919 |
| preparation of an inactivated emc virus vaccine. | 1970 | 4321205 | |
| abnormal dna patterns in animal mitochondria: ethidium bromide-induced breakdown of closed circular dna and conditions leading to oligomer accumulation. | treatment of cultured mouse fibroblasts (l-cells) and hamster kidney cells with ethidium bromide was found to inhibit the incorporation of [(3)h]thymidine into mitochondrial closed-circular dna, but not into nuclear dna. the specific activity of nuclear dna in treated cells was higher than in control cells. treatment also led to breakdown of closed-circular mitochondrial dna, greatly enlarged mitochondrial profiles with few or no cristae, and a higher yield of mitochondrial protein per cell.a si ... | 1970 | 4321352 |
| encephalomyocarditis infection of the newborn mouse myocardium. an electron microscopic study. | 1971 | 4321486 | |
| [myocarditic component of some acute diseases in children]. | 1970 | 4321607 | |
| effect of mengovirus replication on choline metabolism and membrane formation in novikoff hepatoma cells. | infection of novikoff rat hepatoma cells (subline nlsl-67) with mengovirus resulted in a two- to threefold increase in the rate of choline incorporation into membrane phosphatidylcholine at about 3 hr after infection, without affecting the rate of transport of choline into the cell or its phosphorylation. the time course of virus-stimulated phosphatidylcholine synthesis was compared with the time courses of other virus-induced processes during a single cycle of replication. the formation of vira ... | 1970 | 4322083 |
| studies of the early events of the replicative cycle of three variants of mengo encephalomyelitis virus in mouse fibroblast cells. | 1970 | 4322160 | |
| [electron microscopic detection of mengovirus in l cells with ferritin-labeled antibodies]. | 1970 | 4322839 | |
| diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. | 1971 | 4323473 | |
| interferon induction by and infectivity of ultraviolet-irradiated double- and multistranded viral rna's. | 1970 | 4323578 | |
| [stimulating interaction of animal viruses]. | 1970 | 4323595 | |
| interferon-inducing characteristics of mm virus. | interferon induction by mm virus in mice and in l cells was studied. in mice the virus readily induced interferon. the time of appearance was dose-dependent. a large virus dose induced interferon by 4 hr, whereas a small dose resulted in interferon production which paralleled virus replication 24 hr after infection. in l cells the interferon-inducing capacity of the virus was rapidly destroyed by ultraviolet light irradiation. heating (56 c) of the virus, on the other hand, greatly increased its ... | 1971 | 4324191 |
| [virus induced diabetes mellitus in the white mouse]. | 1971 | 4325206 | |
| effect of antilymphocytic serum on circulating interferon in mice as a function of the inducer. | 1971 | 4325471 | |
| immunofluorescent studies on the effect of antiviral substances on virus multiplication. ii. determination of fluorescence intensity in mengo virus infected l cells treated with beta-2-dl-thienylalanine. | 1971 | 4325975 | |
| immunofluorescent studies on the effect of antiviral substances on virus multiplication. 3. effect of actidione on the multiplication of mengo virus. | 1971 | 4325976 | |
| interferon in mouse brain. | 1971 | 4326390 | |
| [inhibition by pironine of rna virus multiplication]. | 1971 | 4327064 | |
| [demonstration of the mengo virus antigen in the mouse brain by help of the immunofluorescence technique]. | 1971 | 4327126 | |
| priming: a nonantiviral function of interferon. | no interferon is made by l cells when they are infected with mm virus. however, several thousand units of interferon are produced when interferon-treated l cells are infected with mm virus. we call the conversion of cells, from nonproducers to producers, priming. the time required for cells to become fully primed is dependent on the interferon concentration with which they are incubated. primed cells produced interferon earlier than normal cells stimulated by other inducers. cells which were exp ... | 1971 | 4327587 |
| duration of resistance to viral infection following administration of interferon inducers. | 1971 | 4328255 | |
| host-cell repair of vaccinia virus and of double stranded rna of encephalomyocarditis virus. | 1971 | 4328801 | |
| virus protein synthesis in animal cell-free systems: nature of the products synthesized in resonse to ribonucleic acid of encephalomyocarditis virus. | ribonucleic acid (rna) from encephalomyocarditis (emc) virus stimulates the incorporation of amino acids into protein in cell-free protein-synthetic systems derived from krebs mouse ascites tumor cells and chick embryo fibroblasts; the mouse system is the more responsive to the viral rna. the greater part of this difference in activity can be ascribed to the cell sap, but the origin of the ribosomes also has a marked effect. the nature of the polypeptides formed in these cell-free systems was in ... | 1971 | 4329561 |
| protein synthesis in cell-free systems: an effect of interferon. | the activity of ribosome and cell-sap fractions from interferon-treated and control chick embryo fibroblasts was compared in mixed chick-mouse and purely chick cell-free systems capable of the synthesis of viral polypeptide(s) in response to viral ribonucleic acid (rna). interferon treatment of cells did not affect the intrinsic amino acid incorporation activity of these systems or their response to polyuridylic acid. with encephalomyocarditis (emc) virus rna as messenger, however, a fraction of ... | 1971 | 4329562 |
| [antiviral activity of imidazole derivatives. i. inhibition of multiplication of mengovirus in fl cells]. | 1971 | 4329638 | |
| [antiviral activity of imidazole derivatives. ii. studies on rna and protein synthesis]. | 1971 | 4329639 | |
| a temporal and structural relationship between viral rna polymerase and nicotinamide adenine dinucleotide pyrophosphorylase in the cytoplasm of krebs-2 ascites cells infected with encephalomyocarditis virus. | 1968 | 4329661 | |
| synthesis of ribonucleic acid by mengovirus-induced rna polymerase in vitro: nature of products and of rnase-resistant intermediate. | 1968 | 4329736 | |
| the relationship between serum interferon and an inhibitor of mouse haemopoietic colonies in vitro. | 1971 | 4329930 | |
| [antiviral activity of imidazole derivates. 3. autoradiographic studies on the influence of 1-butyl-4(4'-allyloxyphenyl)-imidazole-hydrochloride on rna synthesis in mengovirus infected fl cells]. | 1971 | 4330137 | |
| [antiviral activity of imidazole derivatives. iv. sensitivity of different viruses]. | 1971 | 4330139 | |
| studies on the mechanism of protodyne-induced protection against microbial infections. | 1971 | 4330232 | |
| resistance to virus infection during the hyporeactive state of interferon induction. | 1971 | 4330349 | |
| system of double infection between vaccinia virus and mengovirus. | when l cells are simultaneously infected with vaccinia virus and mengovirus, double interference in the replication of both viruses is observed. superinfection of vaccinia virus-infected cells by mengovirus during the first 5 hr of infection reduces vaccinia virus yields to between 1 and 3% of controls. the yields of mengovirus are reduced to between 1 and 16% of controls, depending upon the time of superinfection. the replication of vaccinia deoxyribonucleic acid is not inhibited by mengovirus; ... | 1971 | 4330362 |
| studies of the protein subunit of ph-inactivated mengo virus variants. ii. physicochemical properties. | 1971 | 4330368 | |
| further studies on a purification procedure for encephalomyocarditis virus. | 1971 | 4330790 | |
| interferon levels and resistance to viral infection associated with selected interferon inducers. | 1971 | 4331094 | |
| formation of small plaques by herpes viruses irradiated with ultraviolet light. | 1971 | 4331109 | |
| distribution of initiation factors in cell fractions from mammalian tissues. | 1972 | 4331124 | |
| nucleotide pools in novikoff rat hepatoma cells growing in suspension culture. 3. effects of nucleosides in medium on levels of nucleotides in separate nucleotide pools for nuclear and cytoplasmic rna synthesis. | this study was undertaken to measure the absolute levels of nucleoside pools in novikoff rat hepatoma cells (subline n1s1-67) during growth in suspension culture in the presence of high concentrations of various nucleosides in the medium, and to obtain further evidence for the compartmentalization of the nucleotides in independent cytoplasmic and nuclear pools. the levels of nucleotide pools were measured by growing the cells in medium supplemented with inorganic phosphate-(32)p. the nucleotide ... | 1972 | 4331295 |
| properties of the inferferon-like virus inhibitor released during interaction of mouse sensitized lymphocytes with their target cells. | 1971 | 4331347 | |
| protein synthesis directed by encephalomyocarditis virus rna. ii. the in vitro synthesis of high molecular weight proteins and elements of the viral capsid. | 1971 | 4331472 | |
| synthesis of capsid and noncapsid viral proteins in response to encephalomyocarditis virus ribonucleic acid in animal cell-free systems. | the polypeptide products formed in two cell-free protein-synthetic systems programmed with encephalomyocarditis (emc) virus ribonucleic acid (rna) have been compared with the virus-specific proteins found in emc-infected cells and with the capsid proteins of the purified virion. tryptic peptides of (35)s-methioninelabeled proteins from these three sources were compared by co-chromatography and electrophoresis and by isoelectric focussing. fifty-two methionine-containing peptides were resolved in ... | 1971 | 4331652 |
| repair replication of hela cell deoxyribonucleic acid in cells infected with newcastle disease virus or mengovirus or treated with puromycin. | we examined repair replication of hela cell deoxyribonucleic acid (dna) in cells infected with mengovirus or newcastle disease virus or treated with puromycin. cellular dna was damaged by ultraviolet light and then pulse-labeled with (3)h-thymidine. autoradiographic analysis of non-s-phase dna synthesis (repair replication) showed that there was no inhibition of this process at a time when overall cellular dna synthesis was severely inhibited by either virus infection or puromycin treatment. | 1971 | 4331658 |
| antiviral activity of tobacco leaf on encephalomyocarditis (emc) virus infection. | 1971 | 4331947 | |
| virus-specific proteins synthesized in encephalomyocarditis virus-infected hela cells. | the in vivo synthesis of encephalomyocarditis-specific proteins was studied by labeling the viral proteins with radioactive amino acids under conditions where host-protein synthesis was almost completely inhibited. to assure recovery of all proteins, intact cells were lysed in hot 1% sodium dodecyl sulfate. these lysates were analyzed by quantitative high-resolution electrophoresis on sodium dodecyl sulfate-polyacrylamide gels. this technique allowed the detection and estimation of the molecular ... | 1971 | 4332006 |
| preservation of enteroviruses by freeze-drying. | a method was developed for freeze-dry stabilization of poliovirus type 3. an ultrafiltration procedure was used to remove salts from infected tissue culture fluid, and the virus was freeze-dried after suspension in an alkaline organic buffer. this method was further tested with other picornaviruses including poliovirus types 1 and 2, coxsackieviruses a9, a20, b2, and b5, echovirus 11, and the encephalomyocarditis virus. freeze-dried preparations of the poliovirus could be shipped to distant labo ... | 1971 | 4332042 |
| protein synthesis directed by encephalomyocarditis virus rna: properties of a transfer rna-dependent system. | small amounts of encephalomyocarditis virus rna direct a 50-fold increase in amino acid incorporation, in appropriately supplemented ascites tumor cell extracts, under conditions that give rise to authentic viral polypeptides. incorporation in these crude extracts has a novel characteristic, namely, that it is almost entirely dependent upon the addition of exogenous trna. further, this incorporation is restricted in that trna derived from ascites tumor cells or from rat liver permits translation ... | 1971 | 4332253 |
| [synthesis of the components of the encephalomyocarditis virus. the rna of polymerase reaction in vitro]. | 1971 | 4332925 | |
| cellular dna replication in infections with cytocidal rna viruses. | 1971 | 4332966 | |
| encephalomyocarditis viral valvulitis in new-born mouse. | 1971 | 4333311 | |
| proteinase activity in purified animal viruses. | 1972 | 4333423 | |
| 7-deazanebularin. metabolism in cultures of mouse fibroblasts and incorporation into cellular and viral nucleic acids. | 1972 | 4333510 | |
| [the structure of the replicative form of encephlomycarditis virus rna]. | 1971 | 4333526 | |
| rate of dna chain growth in mammalian cells infected with cytocidal rna viruses. | 1972 | 4333734 | |
| a comparison of the protective effect against mengo virus infection in mice of interferons induced by polyi:c and mengo virus. | 1971 | 4333910 | |
| the early renal lesions of mice infected with encephalomyocarditis virus. | 1972 | 4333963 | |
| early myocardial lesions in encephalomyocarditis (emc) virus infected mice. | 1971 | 4334293 | |
| [action of rifampicin on the vesicular stomatitis virus]. | 1972 | 4335152 | |
| [relation between complementary chains in the molecules of the replicative form of encephalomyocarditis virus rna]. | 1972 | 4335155 | |
| viral infections and diseases of the endocrine system. | 1971 | 4335454 | |
| simple method for the isolation of encephalomyocarditis virus ribonucleic acid. | a simple purification procedure for encephalomyocarditis virus is described, yielding material suitable for extraction of viral ribonucleic acid for use as messenger in animal cell-free systems. | 1972 | 4335665 |
| mural and valvular endocarditis of mice infected with encephalomyocarditis (emc) virus. | 1971 | 4336178 | |
| in vitro translation of cardiovirus ribonucleic acid by mammalian cell-free extracts. | cell-free extracts prepared from ehrlich ascites and mouse l cells synthesize viral proteins in response to encephalomyocarditis virus, mouse elberfeld virus, and mengovirus ribonucleic acid. although hela cell extracts are inactive, their ribosomes are functional in the presence of heterologous supernatant fractions. synthesis depends upon the addition of adenosine triphosphate, guanosine triphosphate, an energy-generating system, and 4 mm mg(2+). initiation is completed during the first 10 to ... | 1972 | 4336562 |
| workshop on viral infection and diabetes mellitus in man. | 1972 | 4336861 | |
| gene order of encephalomyocarditis virus as determined by studies with pactamycin. | previous work has shown that translation of the encephalomyocarditis (emc) viral ribonucleic acid (rna) generates at least three primary products, polypeptides a, f, and c. the a and c polypeptides then undergo post-translational cleavages to complete the production of the stable viral polypeptides (delta, beta, gamma, alpha, g, i, f, h, and e). in this communication we show that a, f, and c are produced in equimolar amounts giving further support to the theory that the rna of picornaviruses has ... | 1972 | 4337167 |
| the effect of priming with interferon on interferon production by two lines of l cells. | 1972 | 4337220 | |
| antiviral activity and side effects of polyriboinosinic-cytidylic acid complexes as affected by molecular size. | the decrease of the molecular size of poly(i.c) to less than 10(6) decreases its ability to induce interferon, protect mice against virus, or enhance the immune response. immune adjuvant activity appeared more sensitive to molecular weight than the other protective activities. the composition of the complex-the molecular size of the individual homopolymers when one was large and the other small-did not affect antiviral activity; the activity of a complex made from large poly(i) and small poly(c) ... | 1972 | 4337241 |
| biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls. | whole mycobacterial cells, which are used in freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. the data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells. | 1972 | 4337242 |
| study of the interaction of soluble and particle-bound nicotinamide adenine dinucleotide pyrophosphorylase with cytoplasmic ribosomes. | 1972 | 4337264 | |
| pancreatic islet cell damage in mice produced by coxsackie b 1 and encephalomyocarditis viruses. | 1972 | 4337357 | |
| the effect of certain amino acids on reproduction of encephalomyocarditis virus. i. investigation of the inhibiting effect of l-lysine. | 1972 | 4337543 | |
| isolation of the minus strand of encephalomyocarditis virus rna. | 1972 | 4337993 | |
| a model for foot-and-mouth disease virus. | 1972 | 4338333 | |
| increased efficiency of exogenous messenger rna translation in a krebs ascites cell lysate. | addition of a 0.5 m kcl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mrnas by krebs-cell lysates. in the presence of the wash fraction, 1 pmol of rabbit or mouse 10s rna directs the incorporation of 80 pmol of leucine into rabbit globin. the addition of human 10s rna results in the synthesis of equal amounts of human alpha and beta chains, identified by column chromatography. the stimulation by the wash fraction is almos ... | 1972 | 4338590 |
| correlation of messenger rna function with adenylate-rich segments in the genomes of single-stranded rna viruses. | oligonucleotides enriched in adenylate residues have been demonstrated in the genomes of two positive-strand rna viruses, sindbis and columbia sk. such oligonucleotides were not found in the genome of vesicular stomatitis virus, a negative-strand virus. the adenylate-rich oligonucleotides from sindbis and columbia sk viruses appeared similar when analyzed by zonal sedimentation in sucrose-sodium dodecyl sulfate. | 1972 | 4338595 |
| an automatic high-precision acrylamide gel fractionator. | 1972 | 4338614 | |
| [isolation of "minus" chain of ribonucleic acid of the murine encephalomyocarditis virus and study of its infectivity]. | 1972 | 4338671 | |
| differential inhibition of nuclear rna polymerases in l cells infected with mengovirus. | 1972 | 4338796 | |
| characterization of the polypeptides formed in response to encephalomyocarditis virus ribonucleic acid in a cell-free system from mouse ascites tumor cells. | the polypeptide products synthesized at different times in a cell-free system from krebs mouse ascites tumor cells in response to the addition of encephalomyocarditis (emc) virus ribonucleic acid (rna) were characterized by electrophoresis on polyacrylamide gels and fingerprint analysis of their tryptic peptides. translation of the emc rna genome with time occurred in a nonrandom fashion in these systems, to yield products containing sequences characteristic of both virion capsid polypeptides an ... | 1972 | 4339197 |
| the emc virus in valves of the heart. | 1972 | 4339455 | |
| further studies on the translation of globin mrna and encephalomyocarditis virus rna in a cell-free system from krebs ii ascites cells. | 1972 | 4339672 | |
| mouse leukemia: depression of serum interferon production. | production of circulating interferon is significantly impaired in akr/j mice after development of lymphoblastic leukemia and in balb/c mice with clinical signs of friend erythroblastic leukemia. this alteration has been observed with three interferon inducers, each one known to elicit an interferon response in different cells. | 1972 | 4340758 |
| isoprinosine: lack of antiviral activity in experimental model infections. | 1972 | 4340925 |