Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [study by electron microscope of the myositis of newborn mice inoculated with echo 9 virus and observations on the structure of the virus]. | 1961 | 13862084 | |
| studies on an out break of echo 9 virus infection in a circumscribed population. | 1959 | 13850633 | |
| [meningitis caused by echo 9 virus. an epidemic with 30 cases in ringkjobig country in 1958]. | 1959 | 13839349 | |
| [localization of an echo-9 virus in the tissues of infected infant mice by means of fluorescing antibodies]. | 1959 | 13825871 | |
| factors determining pathogenicity of variants of echo 9 virus for newborn mice. | while some strains of echo 9 virus were found to be completely incapable of multiplying in newborn mice or even of being adsorbed by their tissues (e.g., the prototype hill strain), other naturally occurring strains readily multiplied even after inoculation of as little as 3 tcd(50) of virus. with the multiplying strains, the infection remained clinically inapparent except after inoculation of very large doses, usually in the range of 10(5) to 10(7.5) tcd(50). investigation of the question why s ... | 1959 | 13819536 |
| structure and development of viruses as observed in the electron microscope. vi. echo virus, type 9. | sequential stages in the development and release of echo 9 virus have been illustrated and described. it is suggested that viral particles differentiate and become oriented in columns upon a fine filamentous lattice at cytoplasmic template sites which are distinct from the endoplasmic reticulum. subsequently, virus is dispersed in the peripheral cytoplasm and gains egress from the cell through rents in the plasma membrane. complete cellular disruption with viral release may supervene. the virus ... | 1961 | 13741584 |
| echo 9 virus in tissue culture observed by light and electron microscopy. | 1960 | 13741583 | |
| echo 9 virus antibody status after an epidemic period and the possible teratogenic effect of the infection. | 1960 | 13739510 | |
| [on the problem of the neuropathogenicity of enteroviruses. experimental studies on the neuropathogenicity of various strains of echo-9 virus]. | 1961 | 13735034 | |
| a football camp outbreak of aseptic meningitis due to echo 9 virus. | 1960 | 13708160 | |
| echo-9 virus antibody titrations in a hela cell system. | 1959 | 13658233 | |
| [studies on pathogenicity of echo-9-virus represented by adaptation experiments with the k 696 strain of echo-9-virus]. | 1959 | 13642771 | |
| neuropathogenicity of non-polio enteroviruses with special reference to echo 9 virus. | 1958 | 13619950 | |
| cases of meningo-encephalitis due to the coxsackie a-like echo 9 virus. | 1958 | 13602961 | |
| epidemic virus meningitis due to echo 9 virus in newfoundland. | 1958 | 13561219 | |
| echo-9 virus exanthema. | 1958 | 13538749 | |
| echo 9 virus infections in eastern canada: clinical and laboratory studies. | 1958 | 13523503 | |
| studies of a coxsackie virus antigenically related to echo 9 virus and associated with an epidemic of aseptic meningitis with exanthem. | 1958 | 13523073 | |
| raxl regulates chick ganglion cell development. | raxl is a paired-like homeobox gene involved in vertebrate eye morphogenesis. we examined raxl protein expression patterns during chick retinal development in combination with ganglion cell markers including the ra4 antigen, cbrn-3, islet-1 and neuronal type iii beta-tubulin. double-immunostaining demonstrated that downregulation of raxl protein correlates with upregulation of ganglion cell markers in the ganglion cell layer (gcl). to explore this correlation in vivo, we performed gain- and loss ... | 2003 | 12963109 |
| outbreaks of aseptic meningitis associated with echoviruses 9 and 30 and preliminary surveillance reports on enterovirus activity--united states, 2003. | aseptic or viral meningitis is the most common type of meningitis and is associated with an estimated 26,000--42,000 hospitalizations each year in the united states. enteroviruses are the most common cause of aseptic meningitis. echovirus 9 (e9) and echovirus 30 (e30) have been associated frequently with outbreaks of aseptic meningitis. during march 2003, several state public health departments noted increased reports of aseptic meningitis and, as of august 7, seven states (arizona, california, ... | 2003 | 12917581 |
| expression of transgenes in primary neurons from chick peripheral and central nervous systems by retroviral infection of early embryos. | many cell biological studies require the expression of transgenes in cells in culture, but it is difficult to obtain uniform, stable, and efficient expression of transgenes in primary neurons. we have approached this problem by adapting from developmental biologists the avian retroviral vector, rcas. this vector allows the introduction of a transgene by infection early in chick embryonic development. transgenes that are less than 2.6 kb in size can be cloned through an adapter vector, slax 12 nc ... | 2003 | 12884700 |
| deletion of pe38 attenuates acmnpv genome replication, budded virus production, and virulence in heliothis virescens. | the pe38 gene product of autographa californica m nucleopolyhedrovirus (acmnpv) has been shown to be involved in transcriptionally transactivating viral genes and augmenting viral dna replication in transient assays. to assess the role of pe38 during infection, we generated a knockout virus, delta pe38-e9/e9, in which the pe38 open reading frame was replaced with that of the green fluorescent protein. we compared mutant and wild-type (wt) viral replication in insect cell culture and virulence in ... | 2003 | 12781710 |
| developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system. | mouse coxsackie virus and adenovirus receptor (mcar), which was isolated from the nerve growth cone-enriched fraction of newborn mouse brains, is a member of immunoglobulin-super family, and functions as a homophilic adhesion molecule. we observed the expression of mcar in embryos to adult tissues by means of immunohistochemical analysis with a peptide antibody. mcar expression was first detected in the embryonic ectoderm in the uterus on embryonic day 6.5 (e6.5). then it was strongly expressed ... | 2003 | 12763576 |
| molecular and biological analysis of echovirus 9 strain isolated from a diabetic child. | the full-length infectious cdna clone was constructed and sequenced from the strain dm of echovirus 9, which was recently isolated from a 6-week-old child at the clinical onset of type 1 diabetes. parallel with the isolate dm, the full-length infectious cdna clone of the prototype strain echovirus 9 barty (barty-inf), was constructed and sequenced. genetic relationships of the sequenced echo 9 viruses to the other members of the human enterovirus type b species were studied by phylogenetic analy ... | 2003 | 12601761 |
| [intrathecal synthesis pattern of immunoglobulins in meningoencephalitis epidemic due to echovirus 9]. | epidemics of meningoencephalitis due to echovirus 9 were commonly occurred when a children population become susceptible for the first time in front the virus. | 2002 | 12436393 |
| functional impairment and killing of human beta cells by enteroviruses: the capacity is shared by a wide range of serotypes, but the extent is a characteristic of individual virus strains. | direct infection of beta cells could explain the diabetogenic effect of enteroviruses. primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses b3, b4, b5) or both, or no apparent immediate adverse effects (coxsackievirus a9). we extended these studies to additional enterovirus serotypes including several echoviruses, some of which have been associated clinically with the development of type i ( ... | 2002 | 12107750 |
| molecular analysis of the echovirus 18 prototype: evidence of interserotypic recombination with echovirus 9. | echovirus 18 (ev18) is one of the echovirus serotypes associated with human diseases and in particular aseptic meningitis. to facilitate studies of the molecular epidemiology of ev18 and the evolution of enteroviruses in general, the complete nucleotide (nt) sequence was determined for the echovirus 18 prototype strain (metcalf, ev18m). excluding the poly a sequence, the genome consists of 7410 nt divided into a 740 nt 5' untranslated region (5' utr), a 6567 nt long open reading frame coding for ... | 2002 | 11955640 |
| design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors. | when skeletons of win compounds were used as templates, computer-assisted drug design led to the identification of a novel series of imidazolidinone derivatives with significant antiviral activity against enterovirus 71 (ev 71), the infection of which had resulted in about 80 fatalities during the 1998 epidemic outbreak in taiwan. in addition to inhibiting all the genotypes (a, b, and c) of ev 71 in the submicromolar to low micromolar range, compounds 1 and 8 were extensively evaluated against a ... | 2002 | 11931618 |
| echovirus 4 and type 1 diabetes mellitus. | to determine the association between exposure to enteroviruses and type 1 diabetes. | 2001 | 11905853 |
| enteroviral meningitis in northern jordan: prevalence and association with clinical findings. | during the summer-autumn of 1999, 390 specimens of cerebrospinal fluid were taken from infants and children younger than 15 years of age. they were suspected of having meningitis and were admitted to princess rahma hospital, northern jordan. they were investigated for the presence of enteroviruses using shell vial culture and indirect immunofluorescence assays. most cases (46.9%) occurred in children younger than 1 year of age in which males represented 71.9%. the common symptoms were fever, vom ... | 2002 | 11782931 |
| molecular evolution of human echovirus 9 isolated from patients with aseptic meningitis in northern kyushu during the summer of 1997. | an epidemic of aseptic meningitis caused by human echovirus 9 (e-9) occurred in the summer of 1997 in northern kyushu, japan. sequences of genome position 2504-3358, which encoded a part of vp1, of the nine isolated viruses were determined. an rgd motif and b-c loop were found in all. they were almost identical and closely related to the virulent strain barty. | 2001 | 11762754 |
| clustered charge-to-alanine mutagenesis of the vaccinia virus a20 gene: temperature-sensitive mutants have a dna-minus phenotype and are defective in the production of processive dna polymerase activity. | although the vaccinia virus dna polymerase is inherently distributive, a highly processive form of the enzyme exists within the cytoplasm of infected cells (w. f. mcdonald, n. klemperer, and p. traktman, virology 234:168-175, 1997). in the accompanying report we outline the purification of the 49-kda a20 protein as a stoichiometric component of the processive polymerase complex (n. klemperer, w. mcdonald, k. boyle, b. unger, and p. traktman, j. virol. 75:12298-12307, 2001). to complement this bi ... | 2001 | 11711621 |
| host selenium status selectively influences susceptibility to experimental viral myocarditis. | the purpose of the present work was to determine whether dietary selenium (se) deficiency could influence the injurious effect of human viruses other than coxsackie virus b3 (cvb3) on mouse heart. weanling c3h/hen mice were fed a se-deficient or se-adequate diet for 4 wk and then were inoculated intraperitoneally with one of the following viruses: coxsackie virus b1 (cvb1), echovirus 9 (ev9), coxsackie virus a9 (cva9), or herpes simplex 1 (hsv1). polio virus 1 (pv1) was employed as a negative co ... | 2001 | 11393307 |
| acute onset of type i diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways. | enterovirus infections have been implicated in the development of type i diabetes mellitus. they may cause beta cell destruction either by cytolytic infection in the pancreas or indirectly by contributing to autoimmune reactivity. we sought evidence for these 2 mechanisms in a case of acute-onset diabetes mellitus that occurred during severe echovirus 9 infection. the virus was isolated and administered to cultured human beta cells. no viral proliferation was observed, and no beta cell death was ... | 2000 | 11049787 |
| echovirus-9 protein 2c binds single-stranded rna unspecifically. | polypeptide 2c is essential for picornavirus replication. although many data on multiple functions of this highly conserved protein are available, the mechanism of rna binding is still obscure. in this work, protein 2c of echovirus-9 strain barty was expressed as a histidine-tagged protein in e. coli followed by nondenaturing purification to homogeneity. after incubation of 2c protein with different kinds of rna fragments, binding was shown in gel retardation assays. competition experiments reve ... | 2000 | 10993936 |
| enteroviruses in spain: virological and epidemiological studies over 10 years (1988-97). | a total of 15,662 clinical samples were analysed for enterovirus (ev) isolation in cell cultures during a 10-year period (1988-97). furthermore, 210 isolates of ev obtained in primary laboratories within spain from patients with meningitis were characterized. the total number of ev typed was 758, including 727 non-polio ev and 31 sabin-like (sl) polioviruses. twenty-eight ev serotypes were represented. echoviruses comprised 90% (653/727) of fully typed non-polio ev. the four most prevalent serot ... | 2000 | 10982074 |
| the picornavirus replication inhibitors hbb and guanidine in the echovirus-9 system: the significance of viral protein 2c. | hbb [2-(alpha-hydroxybenzyl)-benzimidazole] and guanidine are potent inhibitors of picornavirus replication. among other evidence, limited cross-resistance and a synergistic effect of both inhibitors suggest similar but not identical mechanisms of antiviral action. echovirus-9 variants resistant to each of these drugs were characterized and sequenced. complete resistance to hbb or guanidine was shown to be due to single but different point mutations in the non-structural protein 2c. protein 2c w ... | 2000 | 10725414 |
| echovirus 9 strain barty non-structural protein 2c has ntpase activity. | non-structural protein 2c is known to play a fundamental role in the replication of picornaviruses. sequence analyses revealed that 2c belongs to a rapidly expanding group of proteins containing a consensus sequence for nucleotide binding (ntb). we report that echovirus 9 polypeptide 2c displays ntpase activity in vitro. in our experiments, several p2 genes were expressed in escherichia coli as fusion proteins linked to glutathione s-transferase (gst) prior to purification close to homogeneity. ... | 1999 | 10581388 |
| dependence of echovirus 9 on the enterovirus rna replication inhibitor 2-(alpha-hydroxybenzyl)-benzimidazole maps to nonstructural protein 2c. | hbb [2-(alpha-hydroxybenzyl)-benzimidazole] selectively inhibits rna synthesis of most enteroviruses. however, isolation of hbb-dependent variants is possible. sequence analysis and characterization of recombinant viruses revealed that hbb dependence maps to the nonstructural protein 2c. a single point mutation at position c(4782)u is sufficient to establish the hbb-dependent phenotype in our echovirus 9 model. | 1999 | 10559374 |
| spontaneous activation of human immunodeficiency virus type 1 in an immunotoxin-resistant variant t cell line. | we have previously used immunotoxins to select for hiv-1 variant cells that transcribe hiv at extremely low levels and fail to produce hiv proteins. further observation of one of these variants (e9) demonstrated spontaneous in vitro activation of hiv production. the mechanism of activation is different from that of u1 and ach-2, two other cell lines that can be activated to express hiv in vitro. | 1999 | 10515150 |
| integrin alpha(v)beta3 (vitronectin receptor) is a candidate receptor for the virulent echovirus 9 strain barty. | the enterovirus echovirus 9 strain barty (e9/barty) is pathogenic for newborn mice as well as for humans. in contrast to the apathogenic prototype strain hill, strain barty encodes an rgd motif in the c-terminal part of the structural protein vp1. data are presented that show that e9/barty binds its target cells via contact of the rgd motif to the alpha(v)beta3 integrin (vitronectin receptor), whereas prototype hill uses a different, still unidentified receptor site. furthermore, virus titres of ... | 1999 | 10501481 |
| determinants of pathogenicity of echovirus 9 in men: significance of a functional rgd-motif. | in this study, we investigated nine independent echovirus 9 isolates obtained from sick children in 1995. it is discovered that these isolates differ in respect to their pathogenicity for newborn mice indicating that the degree of human pathogenicity of an echovirus 9 variant does not necessarily correlate with mouse pathogenicity. nevertheless, all virus variants are found to code for an rgd-motif within their vp1 protein. hence, the rgd-motif and its highly conserved flanking regions are the c ... | 1999 | 10467665 |
| outbreak of aseptic meningitis due to echo-9 in northern kyushu island in the summer of 1997. | an outbreak of aseptic meningitis caused by echovirus type 9 (echo-9) occurred between june and august 1997 in the chikugo area, fukuoka, japan. clinical manifestations and laboratory data of 317 children with aseptic meningitis were analyzed. the age of the patients ranged from 1 month to 12 years with the highest incidence in 4 years old children. the male: female ratio was 2.0:1.0. symptoms of the meningitis included fever (100%), headache (89.5%) and nausea and/or vomiting (85.6%). skin rash ... | 1999 | 10410528 |
| comparative structural analysis of transcriptionally competent and incompetent rotavirus-antibody complexes. | during genome transcription in rotavirus, as with many segmented double-stranded rna viruses, mrna is transcribed within the intact subviral particle and translocated through specific channels in the capsid. to understand how the conformation of the capsid affects the efficiency of transcriptional events in the viral core, we carried out a series of comparative structural and biochemical studies to characterize four different structural forms of the virus exhibiting differing transcriptional beh ... | 1999 | 10318900 |
| [an epidemic of aseptic meningitis caused by echoviruses in fukuoka prefecture during april 1997 to august 1998]. | an epidemic of aseptic meningitis in fukuoka prefecture during april 1997 to august 1998 was studied to determine the serotype of viruses isolated in fukuoka prefecture. in fukuoka prefecture, bimodal peaks were seen in july and december 1997. monthly changes of reported aseptic meningitis patients and period of virus isolation revealed that epidemics of the earlier part in 1997 was caused by echovirus 9 (e 9) and the latter part due to echovirus 30 (e 30). e 9 was isolated mainly in chikugo are ... | 1999 | 10213990 |
| a genotypic characterization of enteroviral antigenic variants isolated in eastern canada. | antigenic variation within serotypes of enteroviruses can have a significant impact on the effectiveness of routine diagnosis by neutralization assays. the focus of this particular study was to initiate a genetic characterization of echovirus type 9 (e9) antigenic variants and nontypeable strains isolated in canada from 1991 to 1993. all variant strains were initially identified by the serological parameter of neutralization 'breakthrough' during conventional serotyping using the lim-benyesh-mel ... | 1999 | 10082385 |
| molecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis. | in korea, there was a big outbreak of aseptic meningitis in 1993. six clinical isolates of enterovirus were obtained from patients with aseptic meningitis and were identified as echovirus type 9 by serotyping with a pool of neutralizing antisera. for molecular characterization of the isolates, the nucleotide sequences of 5'-noncoding region (ncr), vp4, vp2, vp1, 2a and 2c regions of the isolates were compared with the corresponding regions of echovirus type 9 hill and barty strains. unlike hill ... | 1998 | 9873830 |
| rapid subgrouping of nonpolio enterovirus associated with aseptic meningitis by rflp (restriction fragment length polymorphism) assay. | in korea, there was a big outbreak of aseptic meningitis due to enterovirus infection in 1993. since virus isolation and neutralizing tests are too laborious and time-consuming for the detection of enterovirus from clinical specimen, we have developed a new molecular identification method for rapid subgrouping of isolates from patients with aseptic meningitis. for the rapid subgrouping of isolates, rt-pcr (reverse transcription-polymerase chain reaction) and rflp (restriction fragment length pol ... | 1998 | 9666471 |
| coxsackievirus b1 infection in infants less than 2 months of age. | most of the neonatal enteroviral infections reported in the literature are associated with coxsackievirus b2-b5 and echovirus 9 and 11. we report a retrospective coxsackievirus b1 (cb1) infection in infants less than 2 months of age. seventeen patients had aseptic meningitis and 8 had systemic sepsis (multi-organ involvement including meningitis, impaired liver function, and abnormality in coagulation). the symptoms and signs were nonspecific and could not be distinguished with bacterial infecti ... | 1998 | 9572369 |
| neuroepithelial cells downregulate their plasma membrane polarity prior to neural tube closure and neurogenesis. | cell differentiation often involves changes in cell polarity. in this study we show that neuroepithelial cells, the progenitors of all neurons and macroglial cells of the vertebrate central nervous system, downregulate the polarized delivery to the apical and basolateral plasma membrane domains during development. upon infection of the neuroepithelium of mouse embryos with fowl plague virus (fpv), polarized delivery of the viral envelope hemagglutinin, an apical marker, occurred at the neural pl ... | 1997 | 9486532 |
| cell attachment and mouse virulence of echovirus 9 correlate with an rgd motif in the capsid protein vp1. | the recently analyzed sequences of the nonpathogenic prototype strain hill and the mouse-virulent strain barty of the human echovirus 9 differ particularly in an insertion coding for an rgd motif at the c-terminus of the capsid protein vp1 in the genome of strain barty. to investigate molecular determinants of virulence, we generated a panel of recombinant viruses derived from cdna clones of strains hill and barty. in this communication, we show that the mouse-pathogenic character of strain bart ... | 1997 | 9201224 |
| nucleotide sequencing of a part of the 5'-noncoding region of echovirus type 9 and rapid virus detection during the acute phase of aseptic meningitis. | a part of the 5'-noncoding region of echovirus type 9 isolates was sequenced, and an attempt was made for rapid virus detection in clinical samples obtained from 22 subjects hospitalized with aseptic meningitis. the sequence identity of 440-bp products amplified from the region by rt-pcr was 87.7% between the standard echovirus type 9(hill strain) and the isolates. specific igm antibodies to hill strain were positive in 45.5% by immunofluorescent antibody staining of virus-infected cells. a high ... | 1997 | 9170510 |
| detection of enterovirus by polymerase chain reaction and culture in cerebrospinal fluid of children with transient neurologic complications associated with acute febrile illness. | cerebrospinal fluid samples collected from 23 children with neurologic symptoms, such as febrile seizures, status epilepticus, and transient altered states of consciousness, associated with acute febrile illness, were examined for infectious virus by cell culture. enteroviruses (echovirus type 9 and coxsackievirus b3) were isolated from 2 of the cerebrospinal fluid samples. the samples were also examined for enterovirus by use of the polymerase chain reaction, which could detect nearly the whole ... | 1997 | 9041348 |
| viral meningitis due to echovirus types 6 and 9: epidemiological data from western australia. | during the autumn of 1992, western australia experienced a large viral meningitis outbreak of dual aetiology. of the 161 cases, 64% were children under 15 years of age, with the highest notification rate being in children less than 5 years of age. echovirus 9 caused 41% of cases and occurred mainly in the metropolitan areas of western australia whereas echovirus 6, which caused 37% of cases, was more widespread. an enterovirus was cultured from 70% of csf specimens, 88% of faecal specimens and 6 ... | 1996 | 8972676 |
| molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain barty. | as part of a study of the molecular basis of pathogenicity of echovirus 9, the complete nucleotide sequence of the mouse-virulent echovirus 9 strain barty was determined. excluding the poly(a) tail, the complete rna genome is composed of 7451 bases. the postulated open reading frame extends from nucleotide (nt) 741 to 7349 and predicts a polyprotein of 2203 amino acids (aa). as compared with the sequence of the echovirus 9 prototype strain hill, which is apathogenic for newborn mice, 1492 nt are ... | 1996 | 8879131 |
| complete nucleotide sequence and biological properties of an infectious clone of prototype echovirus 9. | the prototype hill of echovirus 9, a human enterovirus, exhibits no pathogenicity for newborn mice in contrast to some other echovirus 9 strains isolated subsequently during epidemics. in this communication we report the first complete nucleotide sequence and construction of an infectious clone of echovirus 9. aside from the 3' poly(a)-tract, the rna genome is 7420 nucleotides (nt) in length and encodes a single polyprotein of 2193 amino acids (aa). the open reading frame extends from position 7 ... | 1995 | 8837893 |
| echovirus type 9 epidemic in kagoshima, southern japan: seroepidemiology and clinical observation of aseptic meningitis. | an outbreak of aseptic meningitis caused by echovirus type 9 occurred between march and october, 1990, in kagoshima, southern japan. clinical manifestations and laboratory data of 259 children with aseptic meningitis who were admitted to the outpatient clinic of pediatrics in the kagoshima city hospital were analyzed (other diseases caused by echovirus type 9 were not investigated). the patients' age ranged from 1 month to 15 years and the highest incidence was in 4-year-old children. the male:f ... | 1995 | 8559629 |
| laboratory surveillance of viral meningitis by examination of cerebrospinal fluid in cape town, 1981-9. | nine years accumulated laboratory data derived from the culture of the cerebrospinal fluid of 11,360 aseptic meningitis cases were retrospectively reviewed to establish the epidemiology of viral meningitis in cape town. virus was isolated from 3406 of the cases (91% enteroviruses and 9% mumps). five major summer viral meningitis episodes were documented: two of echovirus 4 (706 and 445 cases), echovirus 9 (223), coxsackie a9 (104) and one of unidentified enterovirus (324 cases--probably echo 9). ... | 1993 | 8405162 |
| sch 38057: a picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating. | the activity of a new water-soluble molecule, sch 38057, against picornaviruses is described. sch 38057 inhibited plaque formation of selected entero- and rhinoviruses in a range of 10.2 to 29.1 microm (50% endpoint) and had a therapeutic index of 10 against poliovirus type 2 (polio 2) in hela cells. when administered orally or subcutaneously, sch 38057 protected mice infected with either coxsackievirus b3 (cvb3) or echovirus-9 from mortality. the molecule provided a low level of protection agai ... | 1993 | 8391247 |
| pustulotic arthroosteitis triggered by echovirus 9? | 1993 | 8308799 | |
| fatal case of echovirus type 9 encephalitis. | enteroviruses are rare causes of acute focal encephalitis. a fatal case of echovirus type 9 infection is reported in a 9 month old boy who presented with a fever and a macular rash followed by two focal seizures. echovirus type 9 was isolated from lung tissue after seven days. | 1993 | 8227440 |
| unique insertion sequence and pattern of cd4 expression in variants selected with immunotoxins from human immunodeficiency virus type 1-infected t cells. | to study the variability of human immunodeficiency virus type 1 (hiv-1), we used immunotoxins to select for variants within a population of h9 cells persistently infected with a molecular clone of hiv-1 designated nl4-3. chimeric immunotoxin cd4-pe40 (a chimeric fusion protein consisting of the amino-terminal two domains of cd4 and the carboxy-terminal domains of pseudomonas exotoxin a) was used to select for cells lacking cell surface expression of hiv env (envelope proteins gp160, gp120, and g ... | 1995 | 7983770 |
| sdz 35-682, a new picornavirus capsid-binding agent with potent antiviral activity. | sdz 35-682 is a potent and selective inhibitor of the replication of members of the picornavirus group. it inhibits several rhinovirus serotypes and echovirus 9 at concentrations as low as 0.1 micrograms/ml, without exerting any effect on cell proliferation up to 30 micrograms/ml. as observed with other capsid-binding antipicornavirus compounds, there is a wide variation in sensitivity of the different serotypes within the rhinovirus group. the point of interference of sdz 35-682 in a single cyc ... | 1995 | 7741522 |
| in vivo efficacy of sdz 35-682, a new picornavirus capsid-binding agent. | sdz 35-682 is a potent and selective inhibitor of the replication of members of the picornavirus group. it belongs to the group of uncoating inhibitors binding to the hydrophobic pocket in the capsid of the virion. in cell culture it inhibits several rhinovirus serotypes and echovirus 9 at concentrations as low as 0.1 micrograms/ml. in the echovirus 9 animal model the protective effect of sdz 35-682 was found to be dependent on both, dose of drug and duration of treatment. significant protection ... | 1995 | 7741521 |
| epidemics of aseptic meningitis due to echovirus 30 in japan. a report of the national epidemiological surveillance of infectious agents in japan. | two rages of epidemic of aseptic meningitis (am) due to echovirus 30 (e30) in japan were analyzed with respect to two sources of information, am incidence and e30 isolation, both gathered through the national epidemiological surveillance of infectious diseases. the first e30 epidemic spread throughout japan in 1983 and ceased within the year. the second epidemic, starting in 1989, continued for the three successive years, and in the last year, 1991, the total e30 reports numbered 4,061, the larg ... | 1994 | 7715095 |
| [epidemiologic study of an outbreak of echovirus type-9 meningitis]. | several agents are able to produce lymphocytic meningitis, but sometimes it's not possible their identification. the viruses are the etiological agents more frequently found, especially enteroviruses, mumps virus and herpes simplex virus, with different epidemiological patterns depending on time and geographic location. most of the infections caused by enteroviruses are asymptomatics. in general the viral meningitis have a good prognostic with an acute benign course and serious signs of neurolog ... | 1994 | 7618039 |
| processing of the envelope glycoprotein gp160 in immunotoxin-resistant cell lines chronically infected with human immunodeficiency virus type 1. | we describe the isolation and characterization of variant cell lines which are chronically infected with the human immunodeficiency virus (hiv) and resistant to the action of immunotoxins directed against the hiv envelope protein. these variants all produce normal levels of hiv proteins, budding virions, and the envelope protein precursor gp160. two of the variants, 10e and 11e, contain a mutation within the env gene which results in the production of a truncated precursor and altered processing ... | 1995 | 7474132 |
| [effect of tannin, saponin and guanidine on the replication of echovirus 9 and its mutants]. | 1980 | 7464352 | |
| acute rhabdomyolysis associated with an echovirus 9 infection. | a 28-year-old long-distance runner experienced fever, chills, and brown urine 24 hours after a six-mile run. this was accompanied by a large rise in the creatine phosphokinase level and a rise in echovirus 9 titers from 1:16 to greater than 1:256 during a two-week period. a muscle biopsy specimen showed acute rhabdomyolysis, but no viral inclusion particles. muscle energy metabolism analysis demonstrated no abnormalities. the patient was treated with forced saline diuresis, and he maintained nor ... | 1980 | 7458499 |
| selective inhibition of human neutrophilic chemotaxis by echo virus, type 9. virus-induced changes in membrane fluidity. | by means of the excimer-forming lipid technique changes of membrane fluidity of human pmns exposed to a chemoattractant (fmlp) and/or echo virus, type 9, strain a. barty has been investigated. it was shown that preincubation of pmns with echo 9 virus results in a viral dose-dependent decrease of membrane fluidity of granulocytes exposed to fmlp. the virus-induced rigidity of cell membrane causes obviously a disturbance in the aggregation of membrane particles to form receptors, and thus can lead ... | 1982 | 7182838 |
| biochemistry and pathogenicity of echovirus 9. i. characterization of the virus particles of strains barty and hill. | 1982 | 7147713 | |
| age dependence of paralysis induced by echovirus type 9 in infant mice. | newborn mice of different strains (including nmri) infected with 2-5 x 10(6) pfu of echovirus type 9 strain a. barty developed progressive flaccid paralysis five days after inoculation, followed by death. suckling mice injected with the same infective dose two, four, or six days after birth disclosed at most transient paresis and survived. infectivity titrations revealed in all groups a similar rate of virus multiplication exceeding 10(8) 50% tissue culture infective doses per mouse four days af ... | 1983 | 6854075 |
| analysis of the directed and nondirected movement of human granulocytes: influence of temperature and echo 9 virus on n-formylmethionylleucylphenylalanine-induced chemokinesis and chemotaxis. | the directed movement of human polymorphonuclear leukocytes (pmn) in a plane (zigmond chamber assay) is described by a statistical model. we demonstrate that (a) the movement of a single cell is a superposition of a directed and a random movement, and (b) the degree of orientation, p1, of moving cells in a chemotactic gradient can be determined either by the time average of a single cell or by the average of movement of multiple cells at a fixed time (ergoden hypothesis). however, an homogeneous ... | 1983 | 6853601 |
| f-met-leu-phe and echo 9 virus interaction with human granulocytes. changes of cell membrane structure. | biophysical and biochemical methods were applied for investigation of cell membrane properties of human polymorphonuclear leukocytes (pmns) exposed to the chemotactic peptide n-formylmethionyl-leucylphenylalanine (f-met-leu-phe) and echovirus type 9, strain a, barty. steady-state fluorescence depolarization with diphenylhexatriene demonstrated no gross changes of the total membrane fluidity under the different experimental conditions. however, by means of the monomer-excimer technique with pyren ... | 1984 | 6742107 |
| nonpolio causes of polio-like paralytic syndromes. | in a study of patients with suspected poliomyelitis, but from whom poliovirus was not isolated, a variety of causes of the paralysis was found. injury of the spinal column sometimes followed by periostitis or osteomyelitis was relatively common. exotic causes included paralysis due to snake bite, spider bite, scorpion sting, and tick bite and schistosomiasis involving the spinal cord. chemical poisons, such as arsenic, triorthocresyl phosphate, and organophosphorus insecticides, were responsible ... | 1984 | 6740077 |
| [pathogenicity, for newborn mice, of echovirus type 9 samples isolated from cases of meningitis during an outbreak in rio de janeiro]. | 1983 | 6645951 | |
| echo 9 virus-induced order-disorder transition of chemotactic response of human polymorphonuclear leucocytes: phenomenology and molecular biology. | by means of functional, morphological, and biophysical methods the in vitro interaction of echo virus, type 9, strain a. barty with human polymorphonuclear leucocytes (pmns) was investigated and analyzed by statistical methods. control cells and virus-treated pmns (15 min, 37 degrees c; pmn: virus (pfu)-ratio ranging from 1:1 to 1:50) were exposed to a chemotactic gradient (n-formylmethionyl-leucylphenylalanine = f-met-leu-phe, 10(-8) m/mm) in a zigmond chamber. whereas the track velocity of the ... | 1984 | 6487817 |
| [changes in the membrane fluidity of human neutrophilic granulocytes under the effect of a chemoattractant (fmlp) and of echo virus, type 9, a. barty strain]. | preincubation of human polymorphonuclear leucocytes (pmns) with different concentrations of echo virus, type 9, strain a. barty results in viral dose- and time-dependent inhibition of chemotactic cellular response to chemoattractant (n-formylmethionylleucylphenylalanine = fmlp). in the present experiments, by means of biophysical methods using excimer forming lipids (pyrendecanoic acid) the influence of fmlp and echo 9 virus on membrane fluidity of pmns was investigated. it is shown that the inc ... | 1983 | 6412297 |
| [infections of the central nervous system caused by enterovirus: 223 cases seen at a pediatric hospital between 1973 and 1981]. | between 1973 and 1981, 223 patients were seen at hôpital sainte-justine in montreal for enteroviral infection of the nervous system. in 161 the cause was documented by isolation of an enterovirus from the cerebrospinal fluid (csf). the viruses most frequently isolated were echovirus 11 (36 isolates), echovirus 30 (24), coxsackievirus b2 (23), coxsackievirus b3 (19), echovirus 6 (18), coxsackievirus b5 (16), coxsackievirus a9 (15), echovirus 9 (13), echovirus 7 (12) and coxsackievirus b1 (11). as ... | 1982 | 6291736 |
| a mixed epidemic associated with echovirus types 6 and 11: virologic, clinical and epidemiologic studies. | during 1979, an outbreak of mixed enterovirus infections occurred in kansas city and adjacent communities. sixty-six enteroviruses and 7 adenoviruses were recovered from 73 persons in a survey hospital population. twenty-eight persons yielded echovirus type 11, 22, echovirus type 6, and 16 either echovirus type 9 or coxsackieviruses group b, types 2 and 3. this study describes some of the clinical, virologic and epidemiologic characteristics of the outbreak. a major finding relates to the recove ... | 1981 | 6272570 |
| virus infection of endothelial cells. | endothelial injury is important in the pathogenesis of thrombosis, atherosclerosis, disseminated intravascular coagulation, and vasculitis. the ability of several common human viruses to infect cultures of endothelial cells obtained from human umbilical veins or bovine thoracic aorta was demonstrated. indicators of infection included cytopathology, viral growth curves, and antigen detection by immunofluorescence. herpes simplex virus type 1, adenovirus type 7, measles virus, and parainfluenza vi ... | 1981 | 6260874 |
| ultrastructural degenerative changes of age-dependent echo 9 virus-induced polymyositis in infant mice. | experimental inoculation of newborn nmri mice with echo virus, type 9, strain a. barty *echo 9 virus ab) resulted in diffuse polymyositis 4 days later. the disease, after a delay of 1 day, increased in intensity and was accompanied by a rapid, progressive paresis leading to death 7-11 days following infection. as early as 24-48 h after inoculation, we detected initial ultrastructural degenerative changes, characterized by segmental dilation fo the sarcoplasmic reticulum. disruption and breakage ... | 1981 | 6112816 |
| outbreak of aseptic meningitis due to echo-9 virus. | 1967 | 6047550 | |
| paroxysmal atrial tachycardia associated with echo 9 virus infection. | 1967 | 6024218 | |
| [studies on echo-9 virus. i. serological variation of echo-9 (hill) virus under the influence of temperature]. | 1966 | 5933500 | |
| [summer epidemic of an exanthematous disease induced by echo 9 virus in infants]. | 1966 | 5909653 | |
| [a case of paralytic disease caused by echo 9 virus]. | 1965 | 5827616 | |
| echovirus 9 meningoencephalitis in infants and children. | 1969 | 5818907 | |
| an outbreak among children of aseptic meningitis caused by echovirus type 9. a clinical and serological study. | 1968 | 5706051 | |
| central nervous system disease in humans due to simultaneous epidemics of echovirus type 9 and western encephalomyelitis virus infection in alberta. | 1968 | 5657183 | |
| epidemiologic, clinical and virological findings of exanthematous summer grippe due to echo 9 virus in tokushima district, japan. | 1970 | 5489630 | |
| [epidemics of echo-9 virus meningitis in avignon region]. | 1970 | 5470843 | |
| an epidemic of echo 9 virus meningitis in auckland. | 1966 | 5225621 | |
| aseptic meningitis due to echovirus type 9. | 1972 | 5026336 | |
| laboratory studies of epidemic strains of echovirus 9. | 1971 | 4996500 | |
| effect of echo 9 virus infection on tuberculin sensitivity. | 1969 | 4987091 | |
| genetic characteristics of echovirus type 9 strains: association of mouse virulence with other genetic markers. | 1969 | 4977661 | |
| echovirus type 9 meningitis epidemic in kyushu during the summer of 1967. | 1968 | 4973508 | |
| genetic characteristics of echovirus type 9 strains: selection and characterization of variants. | 1968 | 4971355 | |
| [studies on echo 9 virus. 3. studies on the genetic stability of serological properties of echo 9 "hot" mutant]. | 1968 | 4970249 |