Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| crimean-congo haemorrhagic fever presenting as thrombotic microangiopathy and acute renal failure. | 2006 | 16735392 | |
| phylogeography of the deer mouse (peromyscus maniculatus) provides a predictive framework for research on hantaviruses. | phylogeographical partitioning of sin nombre and monongahela viruses (hantaviruses) may reflect that of their primary rodent host, the deer mouse (peromyscus maniculatus). lack of a comprehensive assessment of phylogeographical variation of the host has precluded the possibility of predicting spatial limits of existing strains of these viruses or geographical regions where novel viral strains might emerge. the complete cytochrome b gene was sequenced for 206 deer mice collected from sites throug ... | 2006 | 16760402 |
| [first serological evidence of hantavirus infection in rodents in colombia]. | determining hantavirus infection prevalence in rodents in the c6rdoba department, colombia. | 2006 | 16925117 |
| characterization of the rna chaperone activity of hantavirus nucleocapsid protein. | hantaviruses are tripartite negative-sense rna viruses and members of the bunyaviridae family. the nucleocapsid (n) protein, encoded by the smallest of the three genome segments (s), has nonspecific rna chaperone activity. this activity results in transient dissociation of misfolded rna structures, may be required for facilitating correct higher-order rna structure, and may function in viral genome replication. we carried out a series of experiments to further characterize the ability of n to di ... | 2006 | 16775315 |
| laboratory study on the immobilization of bacterial spores in arid environments. | in this study, two effective, non-toxic, wind erosion palliative materials were analyzed for their efficacy in preventing the spread of bacterial spores. desert sand was employed in a laboratory setting with a non-toxic simulant bacterium in an attempt to accurately represent the spreadability of the hantavirus. spore simulants were used instead of viruses due to availability, decreased susceptibility to desiccation and detection ability without involving tissue cultures. the simulant was used t ... | 2006 | 16779932 |
| mathematical models for hantavirus infection in rodents. | hantavirus pulmonary syndrome is an emerging disease of humans that is carried by wild rodents. humans are usually exposed to the virus through geographically isolated outbreaks. the driving forces behind these outbreaks is poorly understood. certainly, one key driver of the emergence of these viruses is the virus population dynamics within the rodent population. two new mathematical models for hantavirus infection in rodents are formulated and studied. the new models include the dynamics of sus ... | 2006 | 16794943 |
| truncated recombinant dobrava hantavirus nucleocapsid proteins induce strong, long-lasting immune responses in mice. | we describe the cloning and expression of dobrava hantavirus (dobv) nucleocapsid proteins and a truncated form consisting of the first 118 n-terminal amino acids, and the capacity of these e. coli icone 200-expressed recombinant proteins (rnp) to induce a protective immune response against dobv in mice. as an alternative carrier protein, the outer membrane protein a derived from klebsiella pneumoniae (rp40) has been coupled to different rnp constructs. all recombinant proteins were found to be h ... | 2006 | 16714853 |
| a history of biological disasters of animal origin in north america. | this paper examines past occurrences in north america relevant to the possibility of biological disasters with animal origins. with respect to naturally occurring animal disease outbreaks, north america, while not as adversely affected by epizootics as other regions, has had its fair share of such outbreaks of both 'traditional' and emerging animal diseases. the traditional category includes such diseases as anthrax, classical swine fever, bluetongue, brucellosis, foot and mouth disease, and the ... | 2006 | 16796038 |
| genetic analysis of puumala hantavirus strains from austria. | sequences of the small (s) and the medium (m) genome segments of puumala hantavirus (puuv) were recovered from bank voles clethrionomys glareolus trapped at 2 locations, klippitztörl (carinthia) and ernstbrunn (lower austria). lung tissue samples from 12 rodents earlier found hantavirus antibody-positive were further screened for the presence of hantaviral n-antigen using immunoblotting. rna purified from 7 n-ag-positive samples was subjected to the reverse transcription-polymerase chain reactio ... | 2006 | 16798703 |
| mild course of puumala nephropathy in children in an area with sporadic occurrence hantavirus infection. | the first three children with puumala virus nephropathy diagnosis in the czech republic are reported on. a boy and two girls were admitted with symptoms of interstitial nephritis. the medical history in all children revealed flu-like symptoms. all patients were mildly pyrexial and had elevated erythrocytes sedimentation rate, c-reactive protein and low hemoglobin levels. serum creatinine levels were elevated and proteinuria exceeded 700 mg/l in all children. tubular proteinuria, glycosuria, high ... | 2006 | 17024393 |
| characterization of a new puumala virus genotype associated with hemorrhagic fever with renal syndrome. | hantavirus serotype puumala (puuv) is the etiologic agent of nephropathia epidemica (ne), a mild variant of hemorrhagic fever with renal syndrome (hfrs) in europe, with lethality rates up to 1% among human patients. the serotype puuv is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. we describe a new, geographically and phylogenetically well-defined pathogenic puuv sublineage in southwest germany (st ... | 2006 | 16972039 |
| [acute myopia and progressive acute renal failure in a 28-year old active horsewoman]. | a 28-year old active sportswoman was admitted to hospital suffering from fever, menigeal irritation, acute myopia and progressive acute renal failure. showing signs of polyserositis in combination with pulmonary granulomatous changes a collagenosis as well as an atypical pneumonia was excluded first. due to the renal loss of function a renal biopsy was taken with the typical histological result of a hantavirus infection. this could be confirmed serologically in the following. with symptomatic tr ... | 2006 | 16810539 |
| hantavirus n protein exhibits genus-specific recognition of the viral rna panhandle. | a key genomic characteristic that helps define hantavirus as a genus of the family bunyaviridae is the presence of distinctive terminal complementary nucleotides that promote the folding of the viral genomic segments into "panhandle" hairpin structures. the hantavirus nucleocapsid protein (n protein), which is encoded by the smallest of the three negative-sense genomic rna segments, undergoes in vivo and in vitro trimerization. trimeric hantavirus n protein specifically recognizes the panhandle ... | 2006 | 16971445 |
| developing global climate anomalies suggest potential disease risks for 2006-2007. | el niño/southern oscillation (enso) related climate anomalies have been shown to have an impact on infectious disease outbreaks. the climate prediction center of the national oceanic and atmospheric administration (noaa/cpc) has recently issued an unscheduled el niño advisory, indicating that warmer than normal sea surface temperatures across the equatorial eastern pacific may have pronounced impacts on global tropical precipitation patterns extending into the northern hemisphere particularly ov ... | 2006 | 17194307 |
| evaluation of promed-mail as an electronic early warning system for emerging animal diseases: 1996 to 2004. | to identify emerging animal and zoonotic diseases and associated geographic distribution, disease agents, animal hosts, and seasonality of reporting in the program for monitoring emerging diseases (promed)-mail electronic early warning system. | 2006 | 17014355 |
| tropical infections in the icu. | certain arthropod-borne infections are common in tropical regions because of favorable climatic conditions. water-borne infections like leptospirosis are common due to contamination of water especially during the monsoon floods. infections like malaria, leptospirosis, dengue fever and typhus sometimes cause life threatening organ dysfunction and have several overlapping features. most patients present with classicial clinical syndromes: fever and thrombocytopenia are common in dengue, malaria an ... | 2006 | 16944613 |
| genetic analysis of thailand hantavirus in bandicota indica trapped in thailand. | sixty one tissue samples from several rodent species trapped in five provinces of thailand were examined for the presence of hantaviral markers by enzyme-immunoassay and immunoblotting. four samples, all from the great bandicoot rat bandicota indica, were confirmed positive for the hantaviral n-antigen. two of them were trapped in nakhon pathom province, the other two in nakhon ratchasima province, approximately 250 km from the other trapping site. when analysed by rt-nested pcr, all four rodent ... | 2006 | 16953877 |
| diagnosis and treatment of new world hantavirus infections. | the purpose of this review is to summarize the current knowledge regarding the diagnosis and treatment of indigenous new world hantavirus infections. | 2006 | 16940866 |
| regions of importance for interaction of puumala virus nucleocapsid subunits. | puumala virus (puuv) is a hantavirus that causes a mild form of hemorrhagic fever with renal syndrome in northern and central europe, and in large parts of russia. the nucleocapsid (n) protein encoded by hantaviruses plays an important role in the life-cycle of these viruses, and one important function for the n-protein is to oligomerize, surround and protect the viral rnas. we have identified amino- and carboxy-terminal regions involved in puuv n-n interactions, which comprise amino acids 100-1 ... | 2006 | 16972031 |
| the pathogenic ny-1 hantavirus g1 cytoplasmic tail inhibits rig-i- and tbk-1-directed interferon responses. | hantaviruses cause two diseases with prominent vascular permeability defects, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. all hantaviruses infect human endothelial cells, although it is unclear what differentiates pathogenic from nonpathogenic hantaviruses. we observed dramatic differences in interferon-specific transcriptional responses between pathogenic and nonpathogenic hantaviruses at 1 day postinfection, suggesting that hantavirus pathogenesis may in part be de ... | 2006 | 16973572 |
| [the new-world hantaviruses. ecology and epidemiology of an emerging virus in latin america]. | the hantaviruses are a group of emerging rodent-borne pathogens (family bunyaviridae; genus hantavirus) that are etiologic agents for hemorrhagic fever with renal syndrome (hfrs) in europe and asia and hantavirus cardiopulmonary syndrome (hcps) in the americas. hfrs is associated with rodents of the family muridae, subfamilies murinae and arvicolinae; hps is associated with rodents of the subfamily sigmodontinae. since the identification of hcps in usa in 1993, a large number of cases of hps and ... | 2006 | 16977974 |
| emergency medicine and the public's health: emerging infectious diseases. | in recent years, multiple global forces have contributed to the emergence and widespread distribution of previously unknown disease entities. this article discusses ebola virus, west nile virus, and hantavirus as representative emerging infectious diseases. smallpox is discussed along with concerns about the safety of the smallpox vaccine, given the uncertain risk of bioterrorism and smallpox exposure. ed physicians must become familiar with the presentation, management, and public health impact ... | 2006 | 16982350 |
| tumor necrosis factor-alpha genetic predisposing factors can influence clinical severity in nephropathia epidemica. | severe human infection with hantavirus is characterized by high fever, cold chills, thrombocytopenia, arterial hypotension, acute renal failure, and/or adult respiratory distress syndrome (ards)-like pulmonary involvement, but the clinical course varies greatly between individuals. we investigated whether genetically determined differences in tumor necrosis factor (tnf)-alpha production can influence the severity of hantavirus disease. we studied a tnf-alpha single-nucleotide promoter polymorphi ... | 2006 | 16987073 |
| reversible impairment of myocardial function in hanta virus infection - direct viral effect? | 2006 | 16845572 | |
| new world hantavirus in humans, french guiana. | 2006 | 16972355 | |
| human hantavirus infection, brazilian amazon. | 2006 | 16845782 | |
| prolonged survival of puumala hantavirus outside the host: evidence for indirect transmission via the environment. | the capability of rodent-borne viruses to survive outside the host is critical for the transmission dynamics within rodent populations and to humans. the transmission of puumala virus (puuv) in colonized bank voles (clethrionomys glareolus) was investigated and additional longevity studies in cell culture with puuv and tula (tulv) hantaviruses were performed. wild-type puuv excreted by experimentally infected donor bank voles was shown to be transmitted indirectly between rodents through contami ... | 2006 | 16847107 |
| the changing epidemiology of acute renal failure. | different definitions of acute renal failure (arf) abound. the existence of multiple definitions makes it difficult to determine the true epidemiological characteristics of this condition. despite this difficulty, it has been possible to detect notable variations in the epidemiology of arf during the past few decades. the absolute incidence of arf has increased, while associated mortality rate has remained relatively static. several factors have contributed to this altered epidemiology. here, we ... | 2006 | 16932465 |
| [full length nucleotide sequence analysis of l and m segments of hantavirus q32 strain gene]. | to study the full length l and m sequence of hantavirus q32 strain gene and explore its molecular characters. | 2006 | 16816865 |
| characterization of shock in a hamster model of hantavirus infection. | human hantavirus cardiopulmonary syndrome (hcps) due to andes, sin nombre and other hantaviruses is characterized by severe pulmonary capillary leak and cardiogenic shock. hamsters, the only animal manifesting hcps-like disease, were instrumented with radiotelemeters that enabled ambulatory intracarotid blood pressure recording within an animal biosafety level-4 facility. following infection with andes virus, blood pressure and heart rate decreased slowly in a biphasic manner during the first 7 ... | 2006 | 16950493 |
| loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. | hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome are two diseases caused by hantaviruses. capillary leakage is a hallmark of hantavirus infection. pathogenic hantaviruses are not cytotoxic, but elevated levels of serum lactate dehydrogenase (ldh), indicative of cellular damage, are observed in patients. we report increased levels of serum perforin, granzyme b, and the epithelial cell apoptosis marker caspase-cleaved cytokeratin-18 during puumala hantavirus infection. signi ... | 2006 | 16873286 |
| drotrecogin alpha (activated) in two patients with the hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) is associated with rapid cardiopulmonary collapse from endothelial injury, resulting in massive capillary leak, shock and severe hypoxemic respiratory failure. to date, treatment remains supportive and includes mechanical ventilation, vasopressors and extracorporeal membrane oxygenation, with mortality approaching 50%. two hcps survivors initially given drotrecogin alpha (activated) (daa) for presumed bacterial septic shock are described. vasoactive med ... | 2006 | 16896430 |
| clinical and laboratory findings related to a favorable evolution of hantavirus pulmonary syndrome. | the medical records of 27 patients with hantavirus pulmonary syndrome were analyzed according to the need for invasive mechanical ventilation in relation to the following data up on hospital admission: age, gender, fever, cough, dyspnea, systolic arterial blood pressure, heart rate, levels of hemoglobin, hematocrit, leukocytes, lymphocytes, platelets, creatinine and arterial blood gases. the volume infused during the first 24 hours after admission, the use of inotropic agents, the use of cortico ... | 2006 | 16906244 |
| [two patients with hantavirus infection in the netherlands; substantial increase in incidence in neighbouring countries]. | a 12-year-old girl and a 57-year-old woman were admitted with fever, general malaise, abdominal pain, nausea and vomiting. both patients had acute renal insufficiency based on tubulointerstitial nephritis caused by the genus hantavirus, which was confirmed by blood tests. both patients recovered spontaneously. the neighbouring countries of france, germany and belgium have recently reported 2- to 7-fold increases in the number of hantavirus infections. hantavirus is a zoonotic viral disease that ... | 2006 | 16821456 |
| [study of phylogenetic relations of hantaviruses by using the mutual information method. tula genotype viruses]. | phylogenetic relations were studied in the group of tula viruses (hantavirus genus, bunyaviridae family) of eurasia. the similarity in the nucleotide sequences of segments was estimated by the value of mutual information. the application of this method confirmed that recombinant events might occur in some tula-like viruses of eurasia, as previously presumed by the results of bootscanning and analysis of amino acid sequences. it was found that might be recombination between distinct phylogenetic ... | 2006 | 16826755 |
| sin nombre viral rna load in patients with hantavirus cardiopulmonary syndrome. | to address the role that viral load plays in pathogenesis in patients with hantavirus cardiopulmonary syndrome (hcps), we quantified sin nombre virus s segment viral rna in plasma samples from 27 acutely ill patients. for 6 patients, we examined viral load in matched plasma, urine, and/or tracheal aspirate throughout the time when the patients were in intensive care. peak titers in plasma reached 1.8 x 106 copies/ml; none of the patients had viral rna in urine. titers in tracheal aspirates did n ... | 2006 | 17054070 |
| [a review about nephropathia epidemica]. | we propose a review of history, aetiology, physiopathology, clinical features, treatment and prevention of nephropathia epidemica (ne) which represents the only form of hantavirus infection in belgium. | 2006 | 16910256 |
| oligomerization of hantavirus nucleocapsid protein: analysis of the n-terminal coiled-coil domain. | hantaviruses constitute a genus in the family bunyaviridae. they are enveloped negative-strand rna viruses with a tripartite genome encoding the nucleocapsid (n) protein, the two surface glycoproteins gn and gc, and an rna-dependent rna polymerase. the n protein is the most abundant component of the virion; it encapsidates genomic rna segments forming ribonucleoproteins and participates in genome transcription and replication as well as virus assembly. in the course of rna encapsidation, n prote ... | 2006 | 16940519 |
| serological survey for viral pathogens in turkish rodents. | wild rodents (n = 330) were trapped around the villages of altindere and coşandere (maçka, trabzon province), ayder, ortan, and yolkiyi (camlihemşin, rize province), and bozdag (odemiş, izmir province) in northeastern and western turkey during april 2004. samples were tested for arenavirus, hantavirus, and cowpox virus (family poxviridae, genus orthopoxvirus, cpxv) antibodies by using immunofluorescence assays (ifas). antibodies against arenaviruses were found in eight of 330 (2.4%) rodents. are ... | 2006 | 17092901 |
| geographical distribution of hantaviruses in thailand and potential human health significance of thailand virus. | phylogenetic investigations, sequence comparisons, and antigenic cross-reactivity studies confirmed the classification of thailand virus (thaiv) as a distinct hantavirus species. the examination of sera from 402 rodents trapped in 19 provinces of thailand revealed that five greater bandicoot rats (bandicota indica) and one lesser bandicoot rat (b. savilei) from four provinces were focus reduction neutralization test (frnt) antibody-positive for thaiv. one of 260 patients from surin province in t ... | 2006 | 17124002 |
| hemorrhagic fever with renal syndrome complicated with pregnancy: a case report. | hantaviruses cause two forms of human disease: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome. hantavirus infection can occur in pregnant women and it can have an influence on the maternal and fetal outcomes, although this is a rare finding even in endemic areas. we describe here a recent case of hfrs complicating pregnancy. | 2006 | 16913449 |
| profiling helper t cell subset gene expression in deer mice. | deer mice (peromyscus maniculatus) are the most common mammals in north america and are reservoirs for several zoonotic agents, including sin nombre virus (snv), the principal etiologic agent of hantavirus cardiopulmonary syndrome (hcps) in north america. unlike human hcps patients, snv-infected deer mice show no overt pathological symptoms, despite the presence of virus in the lungs. a neutralizing igg antibody response occurs, but the virus establishes a persistent infection. limitations of de ... | 2006 | 16916450 |
| nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions. | reactive nitrogen intermediates (rni), like nitric oxide (no) and peroxynitrite, have antiviral effects against certain viruses. hantaviruses, like other members of the bunyaviridae family, have previously not been shown to be sensitive to rni. in this study, we compared the effects of no and peroxynitrite on hantavirus replication and free mature virions in vitro, and of inducible nitric oxide synthase (inos) in hantavirus-infected suckling mice. the no-generating compound s-nitroso-n-acetylpen ... | 2006 | 16955520 |
| incubation period of hantavirus cardiopulmonary syndrome. | the potential incubation period from exposure to onset of symptoms was 7-39 days (median 18 days) in 20 patients with a defined period of exposure to andes virus in a high-risk area. this period was 14-32 days (median 18 days) in 11 patients with exposure for <48 hours. | 2006 | 16965713 |
| hantaviruses in serbia and montenegro. | hantaviruses are endemic in the balkan peninsula. an outbreak of hemorrhagic fever with renal syndrome occurred in 2002 in serbia and montenegro. the epidemiologic characteristics and genetic relatedness of dobrava/belgrade virus strains responsible for most cases are described. | 2006 | 16707066 |
| first evidence of fatal hantavirus nephropathy in india, mimicking leptospirosis. | 2006 | 16361279 | |
| a friday afternoon case of apparent anti-glomerular basement nephritis. | 2006 | 16644771 | |
| a pseudotype vesicular stomatitis virus containing hantaan virus envelope glycoproteins g1 and g2 as an alternative to hantavirus vaccine in mice. | we examined whether a vesicular stomatitis virus (vsv) pseudotype bearing the hantavirus envelope glycoproteins (gps) g1 and g2 (vsvdeltag*htn) could be used as a safe and effective alternative to native hantavirus. mice were immunized with purified particles of vsvdeltag*htn. after the second immunization, all mice produced anti-gp antibody as detected in elisa and a neutralization test. after the third immunization, the mice were challenged with hantaan virus. neither anti-np antibody producti ... | 2006 | 16426712 |
| saaremaa hantavirus should not be confused with its dangerous relative, dobrava virus. | 2006 | 16597913 | |
| cellular entry of hantaan virus a9 strain: specific interactions with beta3 integrins and a novel 70kda protein. | cellular entry of pathogenic hantaviruses had been shown to be mediated by beta3 integrins. however, no direct evidence exists that hantavirus binds to beta3 integrins, and integrin beta3 subunit is not expressed on some cells permissive to hantavirus infection. in this report, utilizing beta3-integrin-transfected cho cells, we demonstrated that integrin beta3 subunit renders cho cells susceptible to chinese hantaan virus (htn) strain a9 (isolated in china), and the viral infection was correspon ... | 2006 | 16310165 |
| serological assays for the detection of human andes hantavirus infections based on its yeast-expressed nucleocapsid protein. | the objective of the study was to develop and evaluate igm and igg elisas and an igg western blot test for the serological detection of human infections with andes virus (andv), the major cause of hantavirus cardiopulmonary syndrome (hcps) in south america. | 2006 | 16428893 |
| bidirectional virus secretion and nonciliated cell tropism following andes virus infection of primary airway epithelial cell cultures. | hantavirus pulmonary syndrome (hps) is an acute disease resulting from infection with any one of a number of new world hantaviruses. hps has a mortality rate of 40% and, unlike many other severe respiratory diseases, often occurs in young, healthy adults. infection is usually initiated after inhalation of rodent excreta containing virus particles, but human-to-human transmission has been documented. postmortem tissue samples show high levels of viral antigen within the respiratory endothelium, b ... | 2006 | 16414986 |
| hantaan/andes virus dna vaccine elicits a broadly cross-reactive neutralizing antibody response in nonhuman primates. | at least four hantavirus species cause disease with prominent renal involvement-hemorrhagic fever with renal syndrome (hfrs); and several hantavirus strains cause disease with significant pulmonary involvement-hantavirus pulmonary syndrome (hps). the most prevalent and lethal hantaviruses associated with hfrs and hps are hantaan virus (htnv) and andes virus (andv), respectively. here, we constructed a dna vaccine plasmid (pwrg/ha-m) that contains both the htnv and andv m gene segments. rhesus ma ... | 2006 | 16378630 |
| social status does not predict responses to seoul virus infection or reproductive success among male norway rats. | trade-offs exist among life history strategies that are used to increase survival and reproduction; such that, males that engage in more competitive behaviors may be more susceptible to infection. hantaviruses are transmitted horizontally between rodents through the passage of virus in saliva during wounding and male rodents are more likely to be infected with hantaviruses than females. to determine whether a trade-off exists between dominance and susceptibility to seoul virus infection, male lo ... | 2006 | 16040226 |
| replication and immunoactivity of the recombinant peromyscus maniculatus cytomegalovirus expressing hantavirus g1 glycoprotein in vivo and in vitro. | previously, we have shown that cmv isolated from deer mouse could be used in vivo and in vitro to express sin nombre virus (snv) glycoprotein g1 in deer mice [rizvanov aa, van geelen ag, morzunov s, et al. generation of a recombinant cytomegalovirus for expression of a hantavirus glycoprotein. j.virol. 2003;77(22):12203-10]. in this report, we further characterize replication of wild-type (wt) and recombinant peromyscus cmv (pcmv) in vivo and in vitro using realtime pcr, and infectious center as ... | 2006 | 16125285 |
| [progress on the study of biological characteristic of hantavirus]. | 2006 | 17299972 | |
| tick-borne encephalitis virus in clethrionomys glareolus in the czech republic. | a total of 474 specimens from 157 rodents caught at the military training area of boletice in the south of the czech republic from may to november 1999 were screened for tbev by nested pcr. tbev-specific rna was amplified from lung, kidney, and spleen derived from one clethrionomys glareolus in the first rt-pcr round. sequence analysis revealed a 100% identity to the tbev strain neudoerfl. tbev presence in the sample was confirmed by mouse brain passage of backup samples and cell culture. the re ... | 2006 | 17187572 |
| wildlife, environment and (re)-emerging zoonoses, with special reference to sylvatic tick-borne zoonoses in north-western italy. | over the last century, changes in land-use, modification of agriculture-livestock production systems, disruption of wildlife habitats, increase of human activities, higher frequency of international and intercontinental travels, wider circulation of animals and animal products have contributed to alter the distribution, presence and density of hosts and vectors. as a result, the number of emerging and reemerging diseases, including zoonoses, have greatly increased. some infectious pathogens, ori ... | 2006 | 17361062 |
| implication of phylogenetic systematics of rodent-borne hantaviruses allows understanding of their distribution. | hantaviruses' distribution is reassessed after performing a cladistic analysis on 93 strains isolated from rodents, and one used as outgroup: thottapalayam isolated from a shrew. while most hantaviruses found in wild animals were collected in northern asia, europe, north america, and south america, only thottapalayam and thailand were found in south and southeastern asia. thottapalayam is highly divergent from the other known hantaviruses and may represent the emerging tip of a different lineage ... | 2006 | 17135493 |
| use of igg avidity to indirectly monitor epizootic transmission of sin nombre virus in deer mice (peromyscus maniculatus). | an igg avidity assay was developed to differentiate deer mice that had recently acquired sin nombre virus (snv) from those that were infected in the distant past. using this procedure, low avidity antibodies were predominantly detected in experimentally infected deer mice (89.5%) within the first 30 days post-inoculation. the assay was then applied to sera from naturally infected deer mice collected during a field investigation associated with a cluster of hantavirus pulmonary syndrome cases. a ... | 2006 | 17172381 |
| [study on the coinfection of hantavirus and orientia tsutsugamushi in tissue cell culture]. | to investigate the possibility of hantavirus (hv) and orientia tsutsugamushi (ot) coinfection in their hosts. | 2006 | 17152514 |
| maternal antibodies postpone hantavirus infection and enhance individual breeding success. | the transfer of maternal antibodies from mother to progeny is a well-known phenomenon in avian and mammalian species. optimally, they protect the newborn against the pathogens in the environment. the effect of maternal antibodies on microparasite transmission dynamics may have important consequences for both the fitness of the host and the epizootic processes of the pathogens. however, there is a scarcity of studies examining these effects in free-living wild species. we studied the influence of ... | 2006 | 17015326 |
| [emergence of new pneumonia: besides severe acute respiratory syndrome]. | important epidemiological modifications have been registered in respiratory infections, both in immunocompetent and immunocompromised hosts. pathogens with modified antibiotic susceptibility patterns have emerged, which display an increased antibiotic resistance, such as s. pneumoniae, s. aureus, h. influenzae. this trait has a strong impact on the therapeutic choices, particularly when an empiric antibiotic treatment is selected. the prevalence of bacterial species showing non-susceptibility to ... | 2006 | 17146421 |
| phylogenetic and geographical relationships of hantavirus strains in eastern and western paraguay. | recently, we reported the discovery of several potential rodent reservoirs of hantaviruses in western (holochilus chacarius) and eastern paraguay (akodon montensis, oligoryzomys chacoensis, and o. nigripes). comparisons of the hantavirus s- and m-segments amplified from these four rodents revealed significant differences from each another and from other south american hantaviruses. the alp strain from the semiarid chaco ecoregion clustered with leguna negra and rio mamore (ln/rm), whereas the bm ... | 2006 | 17172380 |
| [isolation and characterization of hantavirus carried by rodents in huludao, liaoning province]. | to investigate the hantavirus infection and their genotype in rodents in huludao. | 2006 | 17152513 |
| development of novel immunoglobulin g (igg), iga, and igm enzyme immunoassays based on recombinant puumala and dobrava hantavirus nucleocapsid proteins. | human infections with asian and european hantaviruses can result in hemorrhagic fever with renal syndromes of differing severities characterized by renal dysfunction and sometimes by pulmonary symptoms. for the serological detection of human infections by hantaviruses relevant for europe, we developed monoclonal antibody capture immunoglobulin g (igg) and iga enzyme-linked immunosorbent assays (elisas) based on yeast-expressed nucleocapsid proteins of puumala and dobrava hantaviruses. moreover, ... | 2006 | 17021245 |
| dynamics of puumala virus infection in bank voles in ardennes department (france). | the hantaviruses (genus hantavirus, family bunyaviridae) include human pathogens and occur worldwide. in western and central europe, the predominant serotype is puumala (puu) virus, which causes epidemic nephropathy. voles are considered to be the main reservoir and the vector of puu virus. a total of 719 rodents (mainly clethrionomys glareolus, apodemus sp.) trapped by capture-mark-recapture (cmr) in four sites in ardennes department (france) between april 2004 and october 2005 were tested for ... | 2006 | 17027178 |
| update on emerging infections from the centers for disease control and prevention. hantavirus pulmonary syndrome--five states, 2006. | 2006 | 17061318 | |
| [epizootology of hemorrhagic fever with renal syndrome in the central chernozem region]. | a total of 5149 small mammals belonging to 16 species were collected from the lipetsk, voronezh, and belgorod regions (40 administrative districts) in 2003-2004 and examined by elisa and ifa to detect hantavirus antigen and antibodies in the lung tissues. hantavirus circulation was revealed in 13 species, the highest hantavirus activity being detected in field (apodemus agrarius) and small wood (a. (s) uralensis) mice (dobrava-belgrad virus), bank (clethrionomis glareolus) (puumala virus) and co ... | 2006 | 17087062 |
| catacamas virus, a hantaviral species naturally associated with oryzomys couesi (coues' oryzomys) in honduras. | the primary objective of this study was to extend our knowledge of the geographical distribution, genetic diversity, and natural host associations of the hantaviruses indigenous to north america. antibody to a hantavirus was found in 5 (20.8%) of 24 coues' oryzomys (oryzomys couesi) and none of 41 other rodents captured near the town of catacamas in eastern honduras, and a hantavirus was isolated from one of the antibody-positive coues' oryzomys. analyses of nucleotide and amino acid sequence da ... | 2006 | 17124003 |
| [hantavirus in zulia state?]. | during the last years, there has been a worldwide rise in the number of infectious diseases caused by newly discovered agents, in some cases and in others, by variants known as emergent or reemergent pathogens. the analysis of the nucleotide sequences of four rna-positive hantaviruses (s. altoni) suggests that the caño delgadito virus is widely distributed in the venezuelan plains. a similar distribution has been found for some isolates and strains of a novel hantavirus (proposed name "mamporal" ... | 2006 | 17176900 |
| deer mouse movements in peridomestic and sylvan settings in relation to sin nombre virus antibody prevalence. | prevalence of antibody to sin nombre virus (snv) has been found to be nearly twice as high in deer mice (peromyscus maniculatus) in peridomestic settings as in sylvan settings in two studies in montana and one in new mexico. we investigated whether this difference may be related to a difference in deer mouse movements in the two settings. we used radiotelemetry to determine home range size and length of movement for 22 sylvan (1991-1992) and 40 peridomestic deer mice (1995-1999). we also determi ... | 2006 | 17255448 |
| [haemorrhagic fever with renal syndrome (hfrs)--hantavirus infection disease appearing in poland]. | authors take up the problem of occurrence of the haemorrhagic fever with renal syndrome in poland and present the measures undertaken by chief sanitary inspectorate, which brought to detection of the first, serologically confirmed case of hfrs in may 2005. they strongly emphasize the existence of the disease on polish territory despite the poor epidemiological recognition, an possibility of its testing. | 2006 | 17345831 |
| changes in sin nombre virus antibody prevalence in deer mice across seasons: the interaction between habitat, sex, and infection in deer mice. | we examined the impact of season and habitat on sin nombre virus (snv) seroprevalence in deer mice (peromyscus maniculatus) in utah's great basin desert from may 2002 through summer 2003. low mouse captures in 2002 limited analysis for that year. in two seasons during 2003, mouse density and sagebrush cover were positively linked (spring: r = 0.8, p = 0.01; summer: r = 0.8, p = 0.04). in the spring, seroprevalence was negatively correlated with density (r = -0.9, p< 0.01); male and female antibo ... | 2006 | 17255449 |
| [a case of haemorrhagic fever with renal syndrome (hfrs)]. | in our article we describe clinical and epidemiological analysis of the first case of haemorrhagic fever with renal syndrome (hfrs)--with serological confirmation--in poland. | 2006 | 17345843 |
| [surveillance on natural infection of rodents with hantavirus in shenzhen city and identification of a hantavirus strain sz2083]. | for clarifying the situation of the natural infection of rodents having hemorrhagic fever with renal syndrome (hfrs) virus and to type hantavirus (hv) using molecular technique in shenzhen city in 2005, and offering guidance for prevention and control of hfrs. | 2006 | 17402203 |
| targeting vascular injury using hantavirus-pseudotyped lentiviral vectors. | restenosis is a pathological condition involving intimal hyperplasia and negative arterial remodeling. gene therapy vectors have shown modest therapeutic effects, but the level of infectivity has been relatively poor. in the present study we have designed a modified lentiviral vector (lv) pseudotyped with a strain of hantavirus (htnv) to improve the transduction efficiency into vascular smooth muscle and endothelial cells in vitro and in vivo. in vivo studies using adult new zealand white rabbit ... | 2006 | 16431160 |
| puumala and tula hantaviruses in france. | the first genome sequences of tula (tulv) and puumala (puuv) hantaviruses undoubtedly originated from france were recovered from tissue samples of european common voles and bank voles captured in jura region. genetic analysis of s and m segments of french puuv strain revealed its highest similarity to strains from neighboring belgium and germany and also from slovakia. on phylogenetic trees, french puuv strain was placed within the central european lineage formed by strains from these three coun ... | 2007 | 17532080 |
| a comparative epidemiological study of hantavirus infection in japan and far east russia. | hantaviruses are causative agents of some severe human illnesses, including hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). the viruses are maintained by rodent hosts, and humans acquire infection by inhaling virus-contaminated excreta from infected animals. to examine the epidemiology of hantavirus infections in japan and far east russia, we conducted epidemiological surveys in these regions. in japan, anti-hantavirus antibodies were found in four rodent sp ... | 2007 | 17405352 |
| lambda interferon (ifn-lambda) in serum is decreased in hantavirus-infected patients, and in vitro-established infection is insensitive to treatment with all ifns and inhibits ifn-gamma-induced nitric oxide production. | hantaviruses, causing hemorrhagic fever with renal syndrome (hfrs) and hantavirus cardiopulmonary syndrome (hcps), are known to be sensitive to nitric oxide (no) and to pretreatment with type i and ii interferons (alpha interferon [ifn-alpha]/ifn-beta and ifn-gamma, respectively). elevated serum levels of no and ifn-gamma have been observed in hfrs patients, but little is known regarding the systemic levels of other ifns and the possible effects of hantaviruses on innate antiviral immune respons ... | 2007 | 17522204 |
| chemokine production predominates in human monocytes infected with tula virus. | many reports suggest the hypothesis of a complex immune response accompanying hantaviral infections. however, little is known about the immunopathogenesis of nonpathogenic hantaviruses, especially tula virus (tulv). the aim of our study was to determine the cytokine/chemokine profile induced after the infection of human macrophages with tulv and the role of viral replication in this process. also, we wanted to establish how the study of tulv is relevant to our previous study of pathogenic hantav ... | 2007 | 17425435 |
| hantavirus infection induces a typical myocarditis that may be responsible for myocardial depression and shock in hantavirus pulmonary syndrome. | despite clinical evidence of myocardial dysfunction, there is no pathological evidence of myocardial injury in hantavirus pulmonary syndrome (hps). the dominant opinion is that the primary cardiac lesion is functional rather than structural. the present study describes hantaviral antigen and particles in the cardiac endothelium and interstitial macrophages in association with a typical myocarditis in hps. human hearts from 14 individuals who died of hps were compared with hearts from 14 individu ... | 2007 | 17436235 |
| characterization and nmr solution structure of a novel cyclic pentapeptide inhibitor of pathogenic hantaviruses. | hantavirus-induced diseases such as hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome are a global health concern. hantavirus cardiopulmonary syndrome caused by sin nombre virus lacks specific therapy and its high mortality makes sin nombre virus a potential bioweapon agent. sin nombre virus entry into susceptible cells requires expression of alpha(v)beta(3) integrin. we recently reported the sequence of a cyclic nonapeptide that inhibited sin nombre virus entry into ... | 2007 | 17441904 |
| [generalized lymphadenitis associated with hashimoto's thyroiditis]. | a 26-year-old pakistani woman was admitted to hospital with fever, nausea and vomiting, abdominal pain and general weakness for the previous two weeks, but no diarrhea or constipation. antibiotic therapy as an out-patient had not provided relief. she also had enlarged cervical lymph nodes. she reported that she had always been in good health before onset of the described symptoms. | 2007 | 17443443 |
| emerging zoonoses and vector-borne infections affecting humans in europe. | the purpose of this study was to assess and describe the current spectrum of emerging zoonoses between 2000 and 2006 in european countries. a computerized search of the medline database from january 1966 to august 2006 for all zoonotic agents in european countries was performed using specific criteria for emergence. fifteen pathogens were identified as emerging in europe from 2000 to august 2006: rickettsiae spp., anaplasma phagocytophilum, borrelia burgdorferi, bartonella spp., francisella tula ... | 2007 | 17445320 |
| radiological findings and their clinical correlations in nephropathia epidemica. | nephropathia epidemica (ne) is a mild form of hemorrhagic fever with renal syndrome (hfrs). its course varies from asymptomatic to fatal. the etiologic agent, puumala virus, belongs to the hantavirus genus of the bunyaviridae family. respiratory symptoms, from common cold to respiratory distress, occur in ne. acute renal failure (arf) is evident in over 90% of hospital-treated ne patients. in this review article, special attention is paid to radiological lung and renal involvement to investigate ... | 2007 | 17453509 |
| detection of dobrava hantaviruses in apodemus agrarius mice in the transdanubian region of hungary. | dobrava hantavirus (dobv) belongs to the genus hantavirus of the family bunyaviridae, and is carried by yellow necked and striped field mice (apodemus flavicollis and apodemus agrarius), respectively. the aim of this study was to detect and genetically characterize new dobv strains in rodents captured in the transdanubian region of hungary. rodent corpses were dissected and lung tissues were used for hantavirus detection by sybr green-based real-time rt-pcr using specific primers located in the ... | 2007 | 17524512 |
| [the evaluation of viral load in patients with hemorrhagic fever with renal syndrome (hfrs) by real-time polymerase chain reaction]. | the system for real-time polymerase chain reaction was developed for detection of puumala virus rnaand quantitative analysis of viral rnaload in clinical samples. dynamics of viral load in blood samples from 12 patients with hfrs (from day 4 to day 17 of the disease) was studied. at day 4 viral rna load varied from 4 x 10(4) to 1 x 10(6) copies/ml. during the period of observation viral load decreased by 10 - 200 times and was not detected in majority of patients to day 11 - 15 of the disease. t ... | 2007 | 17672134 |
| hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) is caused by infection with multiple types of hantaviruses throughout the americas. all strains induce a pulmonary capillary leak syndrome with cardiogenic shock in severe cases, and almost all strains have an overall mortality rate of 35%. some strains in south america are commonly associated with either mild disease without pulmonary edema or severe disease with pulmonary hemorrhage. early recognition during the thrombocytopenic prodrome phase and tra ... | 2007 | 17458773 |
| hantavirus pulmonary syndrome: the sound of a mouse roaring. | 2007 | 17471422 | |
| prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in chile. | andes virus (andv) infection, which has a case fatality rate of 37% in chile, often occurs in household clusters and may be transmitted from person to person. | 2007 | 17471425 |
| temporal analysis of andes virus and sin nombre virus infections of syrian hamsters. | andes virus (andv) and sin nombre virus (snv) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (hps). there are no vaccines or specific drugs to prevent or treat hps, and the pathogenesis is not understood. syrian hamsters infected with andv, but not snv, develop a highly lethal disease that closely resembles hps in humans. here, we performed a temporal pathogenesis study comparing andv and snv infections in hamsters. snv ... | 2007 | 17475651 |
| persistently highest risk areas for hantavirus pulmonary syndrome: potential sites for refugia. | interannual variation in the number of cases of human disease caused by hantaviruses in north america has been hypothesized to reflect environmental changes that influence rodent reservoir populations. this hypothesis postulates that when cases are rare reservoir populations are geographically restricted in patches of suitable habitat. identifying these sites, which is needed to test the hypothesis, has proven to be a challenge. satellite imagery of the u.s. southwest has shown associations amon ... | 2007 | 17479840 |
| analysis of the immune response of hantaan virus nucleocapsid protein-specific cd8+ t cells in mice. | the major histocompatibility complex (mhc) class-i restricted epitope of hantaan virus nucleocapsid protein (n) was identified using overlapping peptides and balb/c mice. using the mhc tetramer derived from the epitope, we found that the level of n-specific cd8(+) t cells increased to approximately 20% of all antigen-specific cd8(+) t cells in a mouse model of transient infection. however, n-specific cd8(+) t cells were undetectable in a mouse model of persistent infection, both in the persisten ... | 2007 | 17481691 |
| mxa-independent inhibition of hantaan virus replication induced by type i and type ii interferon in vitro. | interferons (ifn) induce an antiviral state against hantaan virus (htnv) but the mechanisms responsible for inhibition are unclear. the ifn-inducible mxa is discussed to be important for control of infections with hantaviruses. to characterize the role of endogenous mxa, the inhibition of htnv induced by type i and type ii ifns was compared in vero and a549 cells. ifnalpha and ifngamma reduced production of infectious virions, viral rna, and nucleocapsid protein with the same efficiency, althoug ... | 2007 | 17482705 |
| stable expression of hantavirus h8205 strain g1/il-2 gene and immune protection of the fusion gene. | to explore the feasibility of stable expression of hantavirus h8205 strain g1 segment and human il-2 fusion gene in vero cells, and to examine the immune protection effects on mice vaccinated with this recombinant eukaryotic expression vector containing hantavirus g1 gene and il-2 gene. with the help of lipofectamine, the vero cells were transfected with pcdna3.1/hisb-il-2-g1 and the positive cells were selected by g418. ifat and sds-page electrophoresis were used to determine the stable transfe ... | 2007 | 17497275 |
| [prevalence of antibodies to hantavirus among hemodialysis patients with end-stage renal failure in kaunas and its district]. | the objective of this study was to investigate the prevalence of antibodies to hantaviruses among hemodialysis patients with end-stage renal failure in kaunas and its district. | 2007 | 17551280 |
| hantavirus and arenavirus antibodies in persons with occupational rodent exposure. | rodents are the principal hosts of sin nombre virus, 4 other hantaviruses known to cause hantavirus pulmonary syndrome in north america, and the 3 north american arenaviruses. serum samples from 757 persons who had worked with rodents in north america and handled neotomine or sigmodontine rodents were tested for antibodies against sin nombre virus, whitewater arroyo virus, guanarito virus, and lymphocytic choriomeningitis virus. antibodies against sin nombre virus were found in 4 persons, agains ... | 2007 | 17553266 |
| update on hantavirus in oklahoma: are we missing cases? | hantavirus pulmonary syndrome (hps) was first recognized in 1993. through july 6, 2005, 396 cases have been reported in the us, including 50 from kansas, texas, and oklahoma. we report the second case of hps in oklahoma and present data from rodent testing to support the presence of hantaviruses across oklahoma. we examined oklahoma death certificates for 1999-2003 for possible unreported hps cases. the rate of death in young adults 15-49 years due to acute respiratory distress syndrome was 69% ... | 2007 | 17557601 |
| tula and puumala hantavirus nss orfs are functional and the products inhibit activation of the interferon-beta promoter. | the s rna genome segment of hantaviruses carried by arvicolinae and sigmodontinae rodents encodes the nucleocapsid (n) protein and has an overlapping (+1) open reading frame (orf) for a putative nonstructural protein (nss). the aim of this study was to determine whether the orf is functional. a protein corresponding to the predicted size of tula virus (tulv) nss was detected using coupled in vitro transcription and translation from a cloned s segment cdna, and a protein corresponding to the pred ... | 2007 | 17705180 |