Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| pathogenetic and clinical aspects of the renal involvement in hemorrhagic fever with renal syndrome. | hemorrhagic fever with renal syndrome is the most common clinical manifestation of hantavirus infection. the main target organ is the kidney, resulting in an interstitial hemorrhagic nephritis and sometimes acute tubular necrosis. the pathogenesis is still largely unknown, but several recent studies indicate an important role for immune mechanisms including increased expression of cytokines, for example, tumor necrosis factor. immunohistochemical studies of kidney biopsies have revealed deposits ... | 1997 | 9044447 |
| hantavirus pulmonary syndrome in wisconsin. | in the spring of 1993 an outbreak of a new illness caused by a new pathogen was identified in the southwestern united states. this infection struck relatively young, healthy individuals, was characterized by fever, myalgias, respiratory failure, and a high mortality rate. this illness was caused by a new hantavirus and has been termed hantavirus pulmonary syndrome (hps). the virus is carried by rodents, shed in saliva, urine, and feces. human infection occurs through inhalation of aerosolized vi ... | 1997 | 9046232 |
| [hantavirus: an ignored pandemic in switzerland?]. | as numerous publications attest, knowledge on hantaviruses progressed rapidly since the isolation of the agent of korean hemorrhagic fever in 1978. this trend was even enhanced after the recognition of a previously unknown hantavirus that caused an outbreak of acute respiratory distress syndromes in the southwestern united states in 1993. hantaviruses are carried by rodents worldwide and may cause severe diseases in humans. hantavirus pulmonary syndrome in the new world and hemorrhagic fever wit ... | 1997 | 9082534 |
| phylogenetic methods come of age: testing hypotheses in an evolutionary context. | the use of molecular phylogenies to examine evolutionary questions has become commonplace with the automation of dna sequencing and the availability of efficient computer programs to perform phylogenetic analyses. the application of computer simulation and likelihood ratio tests to evolutionary hypotheses represents a recent methodological development in this field. likelihood ratio tests have enabled biologists to address many questions in evolutionary biology that have been difficult to resolv ... | 1997 | 9092465 |
| phage-displayed peptide targeting on the puumala hantavirus neutralization site. | we have selected ligands for puumala hantavirus, the causative agent of nephropathia epidemica, from a seven-amino-acid peptide library flanked by cysteines and displayed on a filamentous phage. to direct the selection to areas on the virus particle which are essential for infection, phages were competitively eluted with neutralizing monoclonal antibodies specific for the viral glycoproteins. the selected phage populations were specific for the same sites as the antibodies and mimicked their fun ... | 1997 | 9094664 |
| hantavirus infection. | 1997 | 9048125 | |
| hantavirus pulmonary syndrome. | the objective of this report is to summarize the medical literature relevant to the epidemiology, diagnosis, treatment, and control of hantavirus pulmonary syndrome (hps). the english language literature was searched from january 1993 through march 1995, manually and using medline, including conference proceedings and reference lists. we selected relevant articles on clinical aspects of hps. hps is a newly described illness that progresses through three phases: prodromal, cardiopulmonary, and co ... | 1997 | 9097374 |
| hantavirus in argentina. | 1997 | 9121542 | |
| new hantaviruses causing hantavirus pulmonary syndrome in central argentina. | 1997 | 9100632 | |
| common questions about hantavirus pulmonary syndrome. | 1997 | 9103926 | |
| puumala hantavirus genome in patients with nephropathia epidemica: correlation of pcr positivity with hla haplotype and link to viral sequences in local rodents. | reverse transcription-pcr was used to analyze specimens from 20 finnish nephropathia epidemica (ne) patients hospitalized during the period from october 1994 to january 1995. blood and/or urine sediment specimens from seven patients were found to be positive for the genome sequences of puumala hantavirus (puu). pcr positivity of the specimens from the patients correlated well with the hla-drb1*0301 and hla b8 alleles, which previously were shown to associate with severe courses of ne. genetic an ... | 1997 | 9114386 |
| patterns of association with host and habitat: antibody reactive with sin nombre virus in small mammals in the major biotic communities of the southwestern united states. | the distribution and prevalence of antibody reactive with sin nombre virus were determined in mammals in biotic communities of the southwestern united states. small mammals (n = 3,069) of 69 species were trapped in nine communities from lower sonoran desert to alpine tundra. antibody was found in rodents from all communities (overall prevalence = 6.3%); prevalence was lowest at the altitudinal and climatic extremes (0.4% in desert and 2.0% in alpine tundra). antibody occurred in 11% of 928 deer ... | 1997 | 9129529 |
| dobrava hantavirus in estonia: does the virus exist throughout europe? | 1997 | 9149707 | |
| high prevalence of hantavirus antibodies in bank voles (clethrionomys glareolus) captured in the vicinity of households afflicted with nephropathia epidemica. | puumala virus, the causative agent of nephropathia epidemica (ne), occurs endemically in europe and is spread mainly by the bank vole (clethrionomys glareolus). in the vicinity of each of four households afflicted with ne, we studied rodents with regard to population density and prevalence of puumala virus-specific antibodies. for each case area, a control area was randomly selected 10 km away, without regard to the presence of human settlement. during 6,000 trap nights, 328 rodents were caught, ... | 1997 | 9230802 |
| hantavirus infections. | 1997 | 9003738 | |
| emerging infectious diseases: a challenge to all. | emerging infections are defined as diseases of infectious origin with an incidence that has increased within the past two decades or threatens to increase in the near future. some of these diseases are associated with newly discovered infectious agents; others are well-known conditions rapidly increasing in incidence. five emerging infections are reviewed in this article: ehrlichiosis, a tick-borne infection caused by obligate intraleukocytic bacteria; infections caused by vancomycin-resistant e ... | 1997 | 9012271 |
| the english sweating sickness, 1485 to 1551. | 1997 | 9023099 | |
| experimental evaluation of rodent exclusion methods to reduce hantavirus transmission to humans in rural housing. | an experimental assessment of methods to reduce rodent infestations in rural housing was conducted in yosemite national park, california, sequoia/kings canyon national parks, california, and shenandoah national park, virginia. during pretreatment surveys, nearly all (63 of 68) selected units had past or ongoing rodent activity inside. active infestations were found in 58.8% of the units. peromyscus spp. represented 91.2% of all animals caught inside housing units. despite little harborage, roden ... | 1997 | 9158040 |
| single amino acid substitutions in puumala virus envelope glycoproteins g1 and g2 eliminate important neutralization epitopes. | two monoclonal antibody escape virus mutants (mars), rescued from a human mab to glycoprotein 2 (g2) and a bank vole monoclonal antibody (mab) directed to glycoprotein 1 (g1) of puumala virus, strain sotkamo, were produced by using a combination of neutralization tests and antigen detection. the mars and the original virus were analyzed by nucleotide sequencing and the responsible mutations were defined and characterized. the g1 mutation was found to constitute an a to t nucleotide substitution, ... | 1997 | 9140197 |
| serological diagnosis of hantavirus infections by an enzyme-linked immunosorbent assay based on detection of immunoglobulin g and m responses to recombinant nucleocapsid proteins of five viral serotypes. | worldwide, hantaviruses cause more than 100,000 human infections annually. rapid and accurate methods are important both in monitoring acute infections and for epidemiological studies. we and others have shown that the amino termini of hantavirus nucleocapsid proteins (ns) are sensitive tools for the detection of specific antibodies in hantavirus disease. accordingly, we expressed truncated ns (amino acids 1 to 117) in escherichia coli from the five hantaviruses known to be pathogenic to man; ha ... | 1997 | 9114393 |
| the hantaviruses of europe: from the bedside to the bench. | in europe, hantavirus disease can hardly be called an emerging zoonosis; it is rather a rediscovered disease. since 1934 an epidemic condition with primarily renal involvement has been described in sweden. nowadays, hundreds to thousands of cases per year are registered in fennoscandia, fluctuating with the numbers of the specific arvicoline-rodent reservoir, the red bank vole, which carries the main european serotype, puumala (puu). in the early 1980s, the rat-transmitted serotype, seoul (seo), ... | 1997 | 9204306 |
| hantavirus antibodies in new york. | 1997 | 9230017 | |
| [the history of the identification of pulmonary syndrome due to hantavirus in the argentina southern andes]. | 1997 | 9674235 | |
| hantavirus pulmonary syndrome. report of the first three cases in são paulo, brazil. | the hantavirus pulmonary syndrome was first recognized in cases that occurred in the u.s. in 1993, which served as an alert not only for american physicians but also for physicians in other countries for the identification of the disease. in the city of são paulo, brazil, 3 cases of the syndrome were recorded in 1993. the patients were young brothers residing in the mata atlântica (atlantic forest) region submitted to recent deforestation. two of the patients died of acute respiratory insufficie ... | 1997 | 9640788 |
| hantavirus pulmonary syndrome in the province of rio negro, argentina, 1993-1996. | early in 1995 the first case of hantavirus pulmonary syndrome was serologically confirmed in el bolsón (province of río negro, argentina), corresponding to the third outbreak reported in argentina. a total of 26 cases of hps related to the andean region of rio negro province, were reported from 1993 to 1996, 17 in el bolsón, 4 in san carlos de bariloche, and 5 in buenos aires. the incidence rate was 5.03 x 100,000 with a mortality rate of 51.85 x 100. the occurrence of cases was mainly seasonal, ... | 1997 | 9640780 |
| [the pulmonary syndrome produced by hantaviruses]. | 1997 | 9654969 | |
| [emerging infectious diseases--hantavirus infections]. | 1997 | 9480304 | |
| emerging pathogens: the hong kong experience. | 1997 | 9594216 | |
| isolation, characterization and geographic distribution of caño delgadito virus, a newly discovered south american hantavirus (family bunyaviridae). | rodents collected from the venezuelan llanos (plains) during field studies of viral hemorrhagic fever were tested for evidence of hantavirus infection. hantavirus antibody was found in one (7.7%) of 13 oryzomys bicolor, one (3.4%) of 29 rattus rattus, 10 (6.0%) of 166 sigmodon alstoni and one (2.2%) of 45 zygodontomys brevicauda. hantavirus-specific rna was detected in lung tissues from four antibody-positive rodents: two s. alstoni from portuguesa state and one s. alstoni each from cojedes and ... | 1997 | 9498614 |
| impaired pulmonary function in patients with hemorrhagic fever with renal syndrome. | pulmonary and cardiac functions were investigated in 13 patients hospitalized with nephropathia epidemica, a european form of hemorrhagic fever with renal syndrome. as compared with reference values, the patients' diffusion capacity for carbon monoxide was decreased (p = .002) and pulmonary clearance of inhaled technetium-99m-labeled diethylenetriamine pentaacetic acid was increased (p = .002). in four of 11 patients, arterial blood gas analysis disclosed a reduction in partial pressure of o2 (< ... | 1997 | 9402362 |
| hantavirus pulmonary syndrome in the rural area of juquitiba, são paulo metropolitan area, brazil. | 1997 | 9640790 | |
| enhancing laboratory detection of disease. part 2: amplifying information and requisite variety. | 1997 | 10172959 | |
| enhancing laboratory detection of disease. part 3: detecting a hantavirus disease event: a case study. | a purposive syndromic classification diagnostic system, with known means to ends, has been developed that extracts bits of structural information from endogenous laboratory data. an edifice of structural information for organization, regulation, and decision-making was built for determining future pathophysiological events by asking the fewest questions to define the next event uniquely. the structural information is based on laboratory ordering patterns of physicians for patient populations the ... | 1997 | 10173024 |
| modes of seoul virus infections: persistency in newborn rats and transiency in adult rats. | to understand the mode of persistent infection of seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. when 1-day-old rats were inoculated with the ki-83-262 strain, the s segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase pcr. on the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lung ... | 1996 | 9526540 |
| [serologic verification of epidemic hemorrhagic fever during the lifting of the blockade in sarajevo]. | after four years of sarajevo siege, the deblocade started on july 1995. many soldiers involved in the deblocade developed a clinical symptoms of hemorrhagic fever indicating a possible epidemic. | 1996 | 9601761 |
| cocirculation of multiple hantaviruses in texas, with characterization of the small (s) genome of a previously undescribed virus of cotton rats (sigmodon hispidus). | an environmental and laboratory investigation was conducted after a fatal childhood case of hantavirus pulmonary syndrome occurred in deaf smith county, texas in may 1995. a trapping campaign was conducted to identify possible rodent carriers. six species of murid and heteromyid rodents were collected, and at least one hantavirus-seropositive specimen was found in each of the five murid species. tissues from a selection of 11 seropositive specimens were examined by the polymerase chain reaction ... | 1996 | 9025697 |
| [hantavirus infection: a "new" exotic zoonosis among us]. | hantavirus disease is a recently recognized zoonosis. the main vectors are infected but healthy wild rodents or laboratory rats. transmission to man occurs via inhalation of aerosolised excretions. kidneys or lungs are the target organs during the disease, but a systemic affection with multi-organ involvement is possible, and can be fatal. to date, at least 16 different serotypes of hantavirus have been characterized, 8 of them being of clinical importance. each serotype has its own rodent vecto ... | 1996 | 9156672 |
| [a system of immunoenzyme analysis using biotinylated monoclonal antibodies for typing hantavirus antigens]. | enzyme immunoassay with biotin-labeled monoclonal antibodies to puumala virus was used for typing hantavirus antigens. the system is type-specific, that is, it detects puumala virus only, which was demonstrated by typing 9 hantavirus antigens in infected vero e5 cells and by epizootological analysis of an hfrs outbreak in the yegoryevsk district of the moscow region in november-december 1995. the suggested system may be used as an element of eia screening of natural samples in analysis of the sc ... | 1996 | 8999683 |
| hantavirus pulmonary syndrome, renal insufficiency, and myositis associated with infection by bayou hantavirus. | hantaviruses are etiologic agents of hemorrhagic fever with renal syndrome, an acute illness characterized by acute renal insufficiency, proteinuria, and hemodynamic instability. recently, a new world form of hantavirus disease, hantavirus pulmonary syndrome (hps), was recognized; in this form, pulmonary edema is prominent, but renal insufficiency is generally lacking. hps cases from the southeastern united states may be exceptional in that they have exhibited both pulmonary and renal manifestat ... | 1996 | 8879771 |
| isolation and characterization of tula virus, a distinct serotype in the genus hantavirus, family bunyaviridae. | a vero e6 cell culture isolate of tula virus (tul), a hantavirus first detected in european common voles (microtus arvalis and m. rossiaemeridionalis) by rt-pcr was obtained after initial passaging of tul-infected vole lung samples in laboratory-colonized m. arvalis. tul was defined as a classical serotype by a cross-focus-reduction neutralization test (frnt) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. the sequences of s, m and partial l genom ... | 1996 | 9000098 |
| evidence against infection with hantaviruses among forest and park workers in the southwestern united states. | to determine if individuals with extensive exposure to rodent habitats were infected with sin nombre hantavirus (snv), we evaluated forest and park service personnel from the region of endemicity in the southwestern united states. information about work and recreational activities, including exposure to rodents and a history of recent illnesses, was obtained via a standardized questionnaire. serum specimens were also collected. of 140 participating workers, 84 (60%) were primarily engaged in out ... | 1996 | 8842264 |
| a major antigenic domain for the human humoral response to puumala virus nucleocapsid protein is located at the amino-terminus. | nephropathia epidemica (ne), the major form of hemorrhagic fever with renal syndrome in europe, is caused by the hantavirus serotype puumala (puu). the puu virus nucleocapsid protein (n) has been shown to be highly immunogenic both in laboratory animals and in man. we aimed to locate domains important in humoral immune reactivity and to use this information to develop a specific and sensitive enzyme-linked immunosorbent assay (elisa) for serological diagnosis of ne. escherichia coli poly-histidi ... | 1996 | 8793844 |
| [polyclonal immunoenzyme system for determining hantaviral antigens: assessment of specificity using monoclonal antibodies and the polymerase chain reaction]. | genus-specific monoclonal antibodies to nucleocapsid protein of pumala virus and polymerase chain reaction were used to assess the specificity of a previously described polyclonal (based on human igg to pumala hantavirus) enzyme immunoassay (eia) system for detecting hantavirus antigens. parallel testing of crude lung suspensions from wild rodents trapped in different regions of russia for hantavirus antigens and rna showed 100% coincidence of the results of three tests. these data indicate a hi ... | 1996 | 8928502 |
| evidence of hantavirus in wild rodents in northern ireland. | a survey of evidence of rodent hantavirus infection in county down, northern ireland was carried out by using immunofluorescence to detect virus antigen and antibody. antibodies to hantavirus (r22 strain of seoul virus and hantaan 76-118) were found in 11/51 (21.6%) brown rats (rattus norvegicus), 1/31 (3.2%) field mice (apodemus sylvaticus) and 17/59 (28.8%) house mice (mus domesticus). seven rodents had evidence of hantavirus antigen in lung tissues. antibody positive animals were significantl ... | 1996 | 8870634 |
| evidence against person-to-person transmission of hantavirus to health care workers. | unusual, primarily pulmonary, manifestations of hantaviral illness occurring in the southwestern united states raised the possibility of person-to-person transmission of a recently recognized hantavirus, sin nombre virus. to determine whether such transmission had occurred among health care workers (hcws) exposed to patients with confirmed hantavirus pulmonary syndrome, we evaluated hcws who had cared for patients with hantavirus pulmonary syndrome or who had processed specimens from these patie ... | 1996 | 8722939 |
| retrospective diagnosis of a fatal case of the hantavirus pulmonary syndrome, 1980. | 1996 | 8732742 | |
| [retrospective detection of hantavirus clinical infections in argentina]. | hantavirus activity in rodents and human beings in argentina has been known since the 1980's. in this study, we retrospectively investigated hantavirus infections among argentine hemorrhagic fever (ahf) cases notified between 1987 and 1994, without virological confirmation. igg and igm antibodies to hantavirus were tested by elisa. among 1028 patients included in the study, we found 13 recent infections (1.26%) and 13 remote infections (1.26%). igg antibodies determined in 745 healthy persons li ... | 1996 | 8734923 |
| hemorrhagic fever with renal syndrome: first imported case of hantavirus infection in taiwan. | a patient infected with hantavirus, with resultant hemorrhagic fever with renal syndrome (hfrs), is reported. the patient was a 38-year-old man, living in tainan, taiwan, who had been visiting mainland china for 3 months when he suddenly developed fever and chills, generalized myalgia, abdominal pain and petechiae on his chest. he sought treatment in mainland china. his clinical course progressed through febrile, hypotensive, oliguria and polyuria phases. supportive care included one course of h ... | 1996 | 8772056 |
| hantavirus pulmonary syndrome: epidemiology, prevention, and case presentation of a new viral strain. | hantavirus pulmonary syndrome (hps) is a viral infection from a new strain of hantavirus. the hantavirus was first discovered in north america in 1993 after an outbreak of fatal illness on a navajo indian reservation in new mexico. since then, 122 cases of hps (with a high mortality rate of more than 50%) have been reported in 23 states, with the highest prevalence in the four corners area. the reservoir for hantavirus is small rodents, mostly field mice, vole, and chipmunks. it is transmitted t ... | 1996 | 8784877 |
| the role of molecular techniques in the understanding of emerging infections. | emerging infections are defined as infections that are newly identified or recognized, or those whose incidence in humans has significantly increased over the past 20 years. the interaction of several factors contributes to the emergence of infectious disease, including changes in human behavior, technological advances, economic development, increased international travel, microbial adaptation and lapses in public health measures. biomedical research has allowed us to identify and classify previ ... | 1996 | 8796869 |
| antiviral activities of tragacanthin polysaccharides on punta toro virus infections in mice. | tragacanthin polysaccharides from astragalus brachycentrus (av208) and astragalus echidnaeformis (av212) plants, which are devoid of in vitro antiviral activity, were evaluated in a mouse model of punta toro virus (ptv) infection. the ptv (a phlebovirus member of the bunyaviridae family of viruses) is a model for studying the treatment of rift valley fever and hantavirus infections. single intraperitoneal treatments with 12.5-200 mg/kg/day doses of av212 given 24 h before or 4 and 24 h after vir ... | 1996 | 8804797 |
| seroepidemiological survey of wild rats for seoul virus in indonesia. | the prevalence of antibodies against seoul virus was investigated in 655 wild rats (rattus norvegicus, r. rattus, r. rattus diardii, r. exulans, r. tiomanicus) captured in seven port areas of indonesia. twenty-four of 238 r. norvegicus, one of 142 r. rattus and one of 102 r. exulans from two port areas had the antibodies against seoul virus. | 1996 | 8806040 |
| antigenic properties and diagnostic potential of puumala virus nucleocapsid protein expressed in insect cells. | puumala virus (puu) is a member of the genus hantavirus in the family bunyaviridae and the causative agent of nephropathia epidemica, a european form of hemorrhagic fever with renal syndrome. sera of nephropathia epidemica patients react specifically with puu nucleocapsid (n) protein. in order to safely provide large quantities of antigen for diagnostic purposes, puu sotkamo strain n protein was expressed by using the baculovirus system in sf9 insect cells to up to 30 to 50% of the total cellula ... | 1996 | 8748286 |
| [hantavirus infection and the pulmonary syndrome: another new entity to look for in our environment?]. | 1996 | 8756221 | |
| analysis of fatal pulmonary hantaviral infection in new york by reverse transcriptase in situ polymerase chain reaction. | the purpose of this study was to analyze the histological distribution of polymerase chain reaction (pcr)-amplified hantaviral cdna in three cases of fatal hantaviral infection that occurred 2 years ago in long island, ny. the three otherwise healthy patients had a rapid death characterized by fever and pulmonary failure and were identified from the autopsy files at university hospital, stony brook. six autopsy controls with either no pulmonary disease (three) or fatal pneumonitis of known etiol ... | 1996 | 8774123 |
| radiologic findings of the hantavirus pulmonary syndrome. | 1996 | 8779215 | |
| hantavirus infections in the united states: diagnosis and treatment. | definitive diagnosis of acute hantavirus infection requires demonstration of specific igg and igm antibodies and a compatible clinical course; most persons with acute illness will also have viral rna in pbmc which can be detected after rt-pcr amplification. characteristic hematologic and hemodynamic findings are helpful in establishing a presumptive diagnosis of hps in persons with cardiopulmonary symptoms and signs while awaiting the results of serologic testing and pcr. diagnosis during the pr ... | 1996 | 8815682 |
| hantavirus in montana deer mouse populations: preliminary results. | dynamics of small mammal populations and the prevalence of antibodies for hantavirus were determined in six locations in central and western montana (usa). eighteen live-trapping grids were trapped monthly from june through september 1994. deer mouse (peromyscus maniculatus) populations ranged from 0 to over 90 on one-hectare grids. our bleeding technique had no apparent effect on survival of deer mice. deer mice, meadow voles (microtus pennsylvanicus), and sagebrush voles (lagurus curtatus) wer ... | 1996 | 8827681 |
| genetic susceptibility to severe course of nephropathia epidemica caused by puumala hantavirus. | nephropathia epidemica (ne) caused by puumala hantavirus is one type of hemorrhagic fever with renal syndrome (hfrs). there is considerable variability in the clinical severity of ne. many infections are subclinical but the disease can even be fatal. we questioned whether the wide spectrum in the outcome of ne is dependent, on host-related immunological factors by determining the major histocompatibility complex markers (mhc) in 74 adult patients with ne. patients with the most severe course of ... | 1996 | 8770970 |
| inhibition of puumala and tula hantaviruses in vero cells by mxa protein. | human mxa protein is a type i interferon-inducible intracytoplasmic protein, which mediates antiviral actions against a variety of negative-strand rna viruses including influenza a, measles, and vesicular stomatitis viruses. recently, it has also been shown that several members of the bunyaviridae family are inhibited by mxa protein. the hantavirus genus in the bunyaviridae family includes important human pathogenic viruses, e.g., puumala (puuv), hantaan, and sin nombre viruses. tula virus (tulv ... | 1996 | 8862399 |
| sin nombre virus mrna synthesis. | sin nombre (sn) virus is the major etiologic agent of hantavirus pulmonary syndrome, a severe respiratory disease with high mortality. like other hantaviruses, sn virus causes an inapparent chronic infection of the natural rodent reservoir and tends to grow slowly and produce little cytopathic effect even in highly susceptible vero e6 tissue culture cells. an electrochemiluminescent quantitative pcr approach was developed to allow examination of sn virus rna transcription in synchronously infect ... | 1996 | 8862408 |
| pulmonary involvement in nephropathia epidemica: radiological findings and their clinical correlations. | nephropathia epidemica (ne) is a hemorrhagic fever with renal syndrome (hfrs) normally taking a benign clinical course. the etiologic agent, puumala hantavirus is genetically closely related to sin nombre virus, which causes a frequently lethal febrile syndrome with pulmonary involvement (hantavirus pulmonary syndrome, hps). hps is characterized by acute respiratory distress, non-cardiogenic pulmonary edema and severe and hypotension, but usually no significant renal involvement. pulmonary invol ... | 1996 | 8982552 |
| hantavirus antigen detection in kidney biopsies from patients with nephropathia epidemica. | renal biopsies collected from ten patients with serologically confirmed puumalavirus (puuv) infection in the acute stage with renal dysfunction who lived in the same puuv endemic area in the netherlands, were studied histologically, immuno-histochemically and subsequently examined for the presence of viral antigen by immunoperoxidase staining. interstitial hemorrhages and deposition of igm, complement component c3 and fibrin along the basal side of the tubular epithelial cells, were found in puu ... | 1996 | 8982553 |
| sequence analysis of the complete s genomic segment of a newly identified hantavirus isolated from the white-footed mouse (peromyscus leucopus): phylogenetic relationship with other sigmodontine rodent-borne hantaviruses. | four corners (fc) or sin nombre virus, a hantavirus harbored by the deer mouse (peromyscus maniculatus), is the principal etiologic agent of hantavirus pulmonary syndrome (hps). recently, a hantavirus, designated new york (ny) virus, isolated from a white-footed mouse (peromyscus leucopus) captured on shelter island, new york, was molecularly linked to a fatal case of hps occurring in the northeastern united states. to clarify the genetic and phylogenetic relationship between ny and fc viruses a ... | 1996 | 8883362 |
| acute renal failure due to hemorrhagic fever with renal syndrome. | the aim of our study was to analyze the clinical course and outcome of acute renal failure (arf) in patients with hemorrhagic fever with renal syndrome (hfrs). from 1983 to 1995, we treated 33 patients (27 males, 6 females) aged from 16 to 71 years. half of patients were connected with work at a farm or in a forest. the disease was confirmed serologically with indirect immunofluorescence test (ift) and enzyme-linked immunosorbent assay (elisa). in 18 patients percutaneous kidney needle biopsies ... | 1996 | 8875690 |
| unique and conserved features of tula hantavirus m gene encoding envelope glycoproteins g1 and g2. | the sequence of the genomic m segment encoding the surface glycoproteins g1 and g2 of wild-type tula hantavirus (tul) has been determined. analyses of m nucleotide sequences show that tul is genetically distinct from other hantaviruses. comparison to ten currently known hantavirus g1g2 amino acid sequences points out several, presumably functional, regions with substantial homology indicating a common ancestry and similar evolutionary pathways for all members of the hantavirus genus. | 1996 | 8883363 |
| perspectives in fatal epidemics. | this article discusses four epidemics of fatal infectious diseases: a 1993 cluster of deaths among previously healthy persons in the southwestern united states that led to the identification of a new clinical syndrome, hantavirus pulmonary syndrome; the first epidemic of ebola hemorrhagic fever identified in nearly two decades occurring in 1995 in zaire, which resulted in 317 cases with a mortality rate of 77%; an outbreak of legionnaires' disease among cruise ship passengers in 1994; and a 1989 ... | 1996 | 8958175 |
| distribution and genetic heterogeneity of puumala virus in sweden. | small mammals trapped in sweden were analysed for specific antibody responses against three hantavirus serotypes and for the presence of viral antigen. to determine the genetic identity of viral rna in lungs of seropositive bank voles (clethrionomys glareolus), polymerase chain reactions and subsequent partial sequencing of both the m and s segments were employed. the sequences obtained were all identified as puumala (puu) virus, with a high degree of heterogeneity between the different geograph ... | 1996 | 8887490 |
| hantavirus s rna sequence from a fatal case of hps in new york. | in april, 1995, the second fatal case of hantavirus pulmonary syndrome (hps) occurred in the northeast in a new york state resident. using the patient's lung tissue obtained at autopsy, the s genomic rna segment of a hantavirus, designated h-ny1, was amplified by reverse transcriptase-polymerase chain reaction (rt-pcr), cloned, and sequenced. the s rna was found to contain 2084 nucleotides, 6 nucleotides longer than reported by hjelle et al. (1995) for the virus associated with the first northea ... | 1996 | 8890033 |
| characterization of tula virus antigenic determinants defined by monoclonal antibodies raised against baculovirus-expressed nucleocapsid protein. | tula virus was recently discovered by rt-pcr in lung samples from european common voles (microtus arvalis and m. rossiaemeridionalis). since virus isolation attempts had been unsuccessful, no antigen was available for analysis or for use in immunoassays. to circumvent this, complete tula virus nucleocapsid protein (bac-tul-n) was expressed in recombinant baculovirus. rodent antibody end-point titers to bac-tul-n and to truncated n fragments indicated that the nh2-terminal region is the major ant ... | 1996 | 8896239 |
| wild brown rats (rattus norvegicus) as a zoonotic risk on farms in england and wales. | fear of wild rats as carriers of disease is embedded within our culture. surprisingly little is actually known about parasites in wild rat populations. in recent studies aimed to rectify this omission, farms in england and wales were surveyed to identify parasite species present in the rat populations. rats were found to be infected with numerous zoonotic parasites, including cryptosporidium, pasteurella [correction of pasturella], listeria, yersinia, coxiella, and hantavirus. these findings sug ... | 1996 | 8820193 |
| molecular epidemiology: applications of nucleic acid amplification and sequence analysis. | 1996 | 8877333 | |
| molecular approaches to the identification of unculturable infectious agents. | new molecular biologic techniques, particularly representational difference analysis, consensus sequence-based polymerase chain reaction, and complementary dna library screening, have led to the identification of several previously unculturable infectious agents. new agents have been found in tissues from patients with kaposi's sarcoma, non-a, non-b hepatitis, hantavirus pulmonary syndrome, bacillary angiomatosis, and whipple's disease by using these techniques without direct culture. the new me ... | 1996 | 8903225 |
| biotin-labeled antigen: a novel approach for detection of puumala virus-specific igm. | a novel enzyme-linked immunosorbent assay, bla igm-elisa, based on baculovirus-expressed puumala (puu) virus nucleocapsid protein, was developed for rapid diagnosis of nephropathia epidemica. the recombinant antigen (bac-puu-n) was purified to homogeneity by hplc and conjugated to biotin. the biotin-streptavidin system, in combination with the mu-capture technique, rendered the bla igm-elisa a sensitivity similar to or higher than that of puu virus igm mu-capture elisa based on native antigen. t ... | 1996 | 8910652 |
| rodents, human remains, and north american hantaviruses: risk factors and prevention measures for forensic science personnel--a review. | in 1993, a previously unrecognized hantavirus was identified as the cause for a severe form of respiratory distress later termed hantavirus pulmonary syndrome (hps). in the past two years, several distinct hantaviruses, of which many are pathogenic, have been found in rodent populations in the us. rodents shed the virus in their saliva, urine, and feces. humans usually become infected after inhaling either aerosolized droplets of urine or particulates contaminated with rodent excreta. rodents, i ... | 1996 | 8914295 |
| hantaviruses: genome structure, expression and evolution. | 1996 | 8922460 | |
| immune responses to inactivated vaccine in people naturally infected with hantaviruses. | an inactivated hantaan virus vaccine for hemorrhagic fever with renal syndrome (hfrs) was given by injection to 15 people who were naturally infected with either hantaan or seoul viruses. immunofluorescent antibody (ifa), reversed passive hemagglutination inhibition (rphi), hemagglutination inhibition (hi), and neutralization antibody (na) assays were used to measure the antibody titers of the vaccinated people before and after three doses of vaccine. the results indicated that ifa and rphi anti ... | 1996 | 8877768 |
| hantaviral biosafety issues in the autopsy room and laboratory: concerns and recommendations. | the need to perform autopsies on and examine laboratory specimens from patients with hantavirus pulmonary syndrome (hps) has raised questions about biosafety. human illness associated with hantaviruses is usually the result of exposure to infectious aerosols from saliva or excreta of wild rodents. it is unclear whether or nor certain autopsy and laboratory procedures can also generate similar potentially infectious aerosols. as the biosafety information developed for the hps agent is limited and ... | 1996 | 8958293 |
| increased production of nitric oxide in patients with hemorrhagic fever with renal syndrome--relation to arterial hypotension and tumor necrosis factor. | in 15 consecutive subjects hospitalized with nephropathia epidemica, a european form of hemorrhagic fever with renal syndrome, the plasma concentrations of nitrate plus nitrite, stable metabolites of nitric oxide, were determined. from day 3 of onset of disease the concentrations increased, peak levels being reached on days 5 to 7. maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (tnf)-alp ... | 1996 | 8923042 |
| seroepidemiology of hantaan virus infection in taiwan. | in order to investigate the infection rate of hantaan virus in taiwan, a total of 6,536 human serum samples were collected from residents, selected by stratified random sampling, from 19 townships covering four different ethnic groups: aborigines, fukien taiwanese, hakka taiwanese, and mainland chinese. serum samples were screened for hantaan virus antibodies by indirect immunofluorescence. the prototype hantaan virus (76/118)-infected vero e6 cells were used as the viral antigen for the antibod ... | 1996 | 8950687 |
| [new pneumonia pathogens, especially chlamydia pneumoniae and hantaviruses]. | 1996 | 8964681 | |
| quasispecies in wild-type tula hantavirus populations. | tula virus (tul) is a recently detected hantavirus carried by european common voles. reverse transcriptase pcr cloning was used to study tul s segment/n protein quasispecies. both the distribution and character of mutations observed in three mutant spectra indicated limited selection at the protein level. at least 8% of the mutations were neutral or well tolerated; fixation of such mutations may play a role in tul evolution in its natural host. | 1996 | 8971044 |
| emerging and newly identified viral infections. | 1996 | 8880884 | |
| [hantavirus infection in spain: seroepidemiologic study in the province of soria]. | the aim of the present was to study the seroprevalence of hantavirus infection in the province of soria, spain. | 1996 | 8948928 |
| hantavirus pulmonary syndrome in argentina. possibility of person to person transmission. | in march 1995 the first case of a familiar outbreak of hantavirus pulmonary syndrome (hps) was notified in el bolson, in the south of argentina. until december 15, 1996, a total of 77 cases of hps had been notified with 48% mortality, distributed in three geographical areas of the country, south, north and center. during 1996, of the 19 cases from el bolsón, three were local physicians, one of whom -during the prodrome of her illness- travelled to buenos aires to be attended. in the hospital, tw ... | 1996 | 9284576 |
| a severe case of hemorrhagic fever with renal syndrome in singapore. | the incidence of human hantavirus infection in singapore is low. hitherto, only 2 cases of hemorrhagic fever with renal syndrome (hfrs) have been reported. a third case is reported here of a ragman who had the classical manifestations of hfrs, confirmed by serology. in addition, his condition was complicated by liver dysfunction and neurological disturbance. after a protracted stay, the patient was finally discharged from hospital 5 months after the onset of his severe illness. | 1996 | 9280013 |
| [serologic studies of domestic cats for potential human pathogenic virus infections from wild rodents]. | for several viral infections a reservoir in wild rodents has been demonstrated. some of the agents are known or suspected to be pathogenic for humans. because improvements in hygiene have reduced direct human contact with rodents, domestic cats could be acting as active transmitters of these viruses from rodents to man. we selected 4 such pathogens--ortho- and parapox-, hanta- and encephalomyocarditis viruses--which, in different ways, may lead to serious human illness: ortho- and parapoxvirus i ... | 1996 | 9409901 |
| [hantavirus infection]. | 1996 | 9123884 | |
| vector-borne viral diseases in sweden--a short review. | ockelbo disease, caused by a sindbis-related virus transmitted to man by mosquitoes, was first described in the central part of sweden in the 1960s as clusters of patients with fever, arthralgia and rash. an average annual rate of 30 cases was recorded in the 1980s but no cases have been diagnosed during the last few years. nephropathia epidemica (ne) characterized by fever, abdominal pain and renal dysfunction has been known to cause considerable morbidity in sweden during the last 60 years but ... | 1996 | 8800805 |
| [hantavirus-induced acute renal failure]. | 1996 | 9036104 | |
| [the antigenic differentiation of hantaviruses by using monoclonal antibodies]. | 85 hantavirus (hv) strains from russia and other counties were examined by indirect fluorescent antibody test using monoclonal antibodies (mabs) prepared against hantaviruses: hantaan (hantaan 76-118, a-9 strains), seoul (sr-1, r-22 strains) and puumala (hallnas 83-223 strain). 68 hv strains were differentiated into five virus type groups: hantaan, puumala, seoul, prospect hill and belgrade-dobrava. 17 strains were found to be antigenically closely related but distinct from hantaan type (4 strai ... | 1996 | 9036285 |
| [hantavirus disease]. | 1996 | 9181739 | |
| new pathogens for respiratory infections. | the emergence of new pathogens and the increasing antimicrobial resistance patterns of old pathogens are contributing factors to the high epidemiologic impact of lower respiratory tract infections. hantaviruses, chlamydia pneumoniae, and penicillin-resistant streptococcus pneumoniae have recently gained most of the attention of international researchers. hantavirus pulmonary syndrome has been confirmed in 100 cases with a very high mortality (52%). risk factors for infection are peridomestic cle ... | 1996 | 9363136 |
| a soldier in respiratory distress. | 1996 | 8531548 | |
| hantavirus pulmonary syndrome-related virus from bolivia. | 1996 | 8531560 | |
| ehrlichia infection as a cause of severe respiratory distress. | 1996 | 8532017 | |
| hantavirus serologies in patients hospitalized with community-acquired pneumonia. | in many patients, the etiology of community-acquired pneumonia is not known but may be caused by previously undescribed pathogens in some cases. the recently identified hantavirus sin nombre (sn) causes hantavirus pulmonary syndrome. because sporadic cases have occurred outside the range of its reservoir (the deer mouse peromyscus maniculatus), an investigation sought to determine whether hantaviruses contributed to cases of community-acquired pneumonia in a large baltimore hospital. acute-phase ... | 1996 | 8537665 |
| hantavirus pulmonary syndrome in florida: association with the newly identified black creek canal virus. | hantavirus pulmonary syndrome (hps) is a recently recognized viral zoonosis. the first recognized cases were caused by a newly described hantavirus. sin nombre virus (previously known as muerto canyon virus), isolated from peromyscus maniculatus (deer mouse). we describe a 33-year-old floridian man who resided outside the ecologic range of p maniculatus but was found to have serologic evidence of a hantavirus infection during evaluation of azotemia associated with adult respiratory distress synd ... | 1996 | 8579086 |
| utility of emergency, telephone-based national surveillance for hantavirus pulmonary syndrome. hantavirus task force. | on may 27, 1993, in response to the outbreak investigation of newly recognized hantavirus pulmonary syndrome (hps) in the four corners states (new mexico, arizona, utah, and colorado), the centers for disease control and prevention established a national surveillance case definition for severe, unexplained respiratory disease to determine the extent of hps throughout the united states. a toll-free telephone hotline number was instituted to provide updated information about unexplained respirator ... | 1996 | 8569020 |
| histopathology of peromyscus leucopus naturally infected with pathogenic ny-1 hantaviruses: pathologic markers of hps viral infection in mice. | hantavirus research is impeded by the absence of animal models of viral pathogenesis. we have studied the histopathology of mice (p. leucopus) naturally infected with the ny-1 hantavirus on shelter island, new york. five mice were determined to be seropositive in western blotting to four corners virus nucleocapsid protein and had serum antibodies to seoul and puumala hantavirus antigens by immunofluorescence assay. hantavirus gene segments of the ny-1 hantavirus were identified in these mice and ... | 1996 | 8600313 |