Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| analysis of puumala hantavirus genome in patients with nephropathia epidemica and rodent carriers from the sites of infection. | reverse transcription-polymerase chain reaction (rt-pcr) followed by sequence and phylogenetic analyses were used to study specimens from nine finnish nephropathia epidemica (ne) patients admitted to hospital during the epidemic in winter 1996-1997. blood samples from six patients were found to be positive for the partial m- and/or s-segment sequences of puumala hantavirus (puuv). analyses of these sequences (nt 2168-2610 for the m segment, and nt 819-1082 for the s segment) revealed six distinc ... | 1999 | 10502274 |
| relationships of deer mouse movement, vegetative structure, and prevalence of infection with sin nombre virus. | the effects of vegetative structure on movement of deer mice (peromyscus maniculatus) were examined in two distinct vegetation associations, one near hesperus and the other near molina in western colorado (usa) from june-october 1994 to october 1998. we monitored movement by live-trapping small mammals within gambel's oak/mixed-grass (hesperus) and sage brush/juniper (molina) vegetation types. vegetative structure differed between the sites with molina having more cover provided by shrubs and he ... | 1999 | 10231758 |
| genetic evidence of dobrava virus in apodemus agrarius in hungary. | using nested polymerase chain reaction, we sequenced dobrava virus (dob) from the rodent apodemus agrarius in hungary. the samples we isolated group with dob samples previously isolated from a. flavicollis. this grouping may indicate host switching. | 1999 | 10341190 |
| acute sin nombre hantavirus infection without pulmonary syndrome, united states. | hantavirus pulmonary syndrome (hps) occurs in most infections with sin nombre virus and other north american hantaviruses. we report five cases of acute hantavirus infection that did not fit the hps case definition. the patients had characteristic prodromal symptoms without severe pulmonary involvement. these cases suggest that surveillance for hps may need to be expanded. | 1999 | 10511527 |
| a midcourse assessment of hantavirus pulmonary syndrome. | 1999 | 10081689 | |
| navigational instinct: a reason not to live trap deer mice in residences. | 1999 | 10081690 | |
| recombination in tula hantavirus evolution: analysis of genetic lineages from slovakia. | to examine the evolution of tula hantavirus (tul), carried by the european common vole (microtus arvalis and m. rossiaemeridionalis), we have analyzed genetic variants from slovakia, the country where the virus is endemic. phylogenetic analysis (phylip) based on either partial (nucleotides [nt] 441 to 898) or complete n-protein-encoding sequences divided slovakian tul variants into two main lineages: (i) strains from eastern slovakia, which clustered with russian strains, and (ii) strains from w ... | 1999 | 9847372 |
| dna vaccination with hantavirus m segment elicits neutralizing antibodies and protects against seoul virus infection. | seoul virus (seov) is one of four known hantaviruses causing hemorrhagic fever with renal syndrome (hfrs). candidate naked dna vaccines for hfrs were constructed by subcloning cdna representing the medium (m; encoding the g1 and g2 glycoproteins) or small (s; encoding the nucleocapsid protein) genome segment of seov into the dna expression vector pwrg7077. we vaccinated balb/c mice with three doses of the m or s dna vaccine at 4-week intervals by either gene gun inoculation of the epidermis or n ... | 1999 | 10069952 |
| emerging viral infections. | 1999 | 10079847 | |
| [hantavirus infection]. | 1999 | 10088345 | |
| long-term studies of hantavirus reservoir populations in the southwestern united states: a synthesis. | a series of intensive, longitudinal, mark-recapture studies of hantavirus infection dynamics in reservoir populations in the southwestern united states indicates consistent patterns as well as important differences among sites and host-virus associations. all studies found a higher prevalence of infection in older (particularly male) mice; one study associated wounds with seropositivity. these findings are consistent with horizontal transmission and transmission through fighting between adult ma ... | 1999 | 10081681 |
| [acute hantavirus infection caused by a genetically newly identified viral strain. severe and complicated course of hemorrhagic fever with renal syndrome (nephropathia epidemica)]. | a 49-year-old patient, a hobby hunter, fell ill acutely with joint and limb pain, abdominal pain, nausea and subfebrile temperatures. at hospitalization, the patient was in bad general condition, showing ascites and lid edema, and acute renal failure was diagnosed. | 1999 | 10081288 |
| hantavirus (bunyaviridae) infections in rodents from orange and san diego counties, california. | during a screening program to determine the extent of hantavirus activity in orange and san diego counties, california, serum samples from 2,365 rodents representing nine genera and 15 species were tested for hantavirus antibodies. a reverse transcription-polymerase chain reaction on selected seropositive rodents was used to identify the specific hantavirus. rodents positive for sin nombre virus (snv) antibodies by western blot included 86 (9.1%) of 948 deer mice (peromyscus maniculatus), four ( ... | 1999 | 9988327 |
| isolation and characterization of dobrava hantavirus carried by the striped field mouse (apodemus agrarius) in estonia. | dobrava hantavirus (dob) was isolated from the striped field mouse (apodemus agrarius) trapped on saaremaa island, estonia, and its genetic and antigenic characteristics were subsequently analysed. phylogenetic analysis showed that the estonian dob strain, together with several wild strains carried by apodemus agrarius, forms a well-supported lineage within the dob clade. the topography of the trees calculated for the s, m and l nucleotide sequences of the estonian dob suggests a similar evoluti ... | 1999 | 10073697 |
| [topics of emerging, re-emerging infectious diseases]. | 1999 | 10866500 | |
| [an epidemiological analysis of hemorrhagic fever with renal syndrome morbidity in the republic of bashkortostan in 1997]. | the outbreak of hemorrhagic fever with renal syndrome (hfrs) in the republic of bashkortostan, resulting in 10,057 registered cases of the disease (287 cases per 100,000 of the population), was analyzed. hfrs cases among the population were registered in 52 out of 54 regions of bashkortostan. 31% of the total number of patients were the inhabitants of rural regions (170 cases per 100,000) and 69% were urban dwellers (295 cases per 100,000), mainly in ufa (512 cases per 100,000). hfrs morbidity a ... | 1999 | 10876849 |
| intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. ribavirin study group. | intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (hps) in the united states between 4 june 1993 and 1 september 1994. therapy was initiated prior to laboratory confirmation of hantavirus infection because most deaths from hps occur within 48 h of hospitalization. thirty patients with confirmed hps, 105 patients without hps and 5 patients without adequate diagnostic testing for hps were enrolled. this ... | 1999 | 10723500 |
| [baculovirus: an example of an insect virus of use to humans]. | baculovirus is a viral pathogen of insects in general and lepidoptera in particular. the genome of this large virus consists of a circular, infectious bicatenary dna molecule. at the end of its replication cycle in insects, baculovirus produces a large quantity of at least two proteins, i.e., polyedrine and polypeptide p10. these proteins are essential for transmission of the virus in nature, but are not necessary in cell cultures. using molecular recombinant techniques, one or both of the genes ... | 1999 | 10901857 |
| hantavirus dobrava infection with pulmonary manifestation. | dobrava virus infection was diagnosed serologically by enzyme-linked immunosorbent and immunofluorescence assays. to determine which hantavirus serotype was involved, sera were analyzed by a focus reduction neutralization test. the clinical data indicated that only pulmonary manifestation was present. our data support the presence of dobrava virus infection outside the balkan region. in conclusion, a previously healthy adult with unexplained pulmonary perfusion failure should be investigated for ... | 1999 | 10691093 |
| [hantavirus pulmonary syndrome in southern chile]. | 1999 | 10436725 | |
| intramuscular inoculation of sin nombre hantavirus cdnas induces cellular and humoral immune responses in balb/c mice. | to examine whether genetic immunization with sin nombre (sn) hantavirus genes could elicit immune responses, nine fragments spanning the envelope glycoprotein genes g1 and g2, and the complete n gene were cloned into a cmv expression vector. to ensure representation of all potential epitopes, adjacent fragments of the glycoprotein genes overlapped one another by 100 nucleotides. vectors containing the gene fragments were inoculated intramuscularly into balb/c mice and splenocyte proliferation an ... | 1999 | 10438054 |
| update: hantavirus pulmonary syndrome--united states, 1999. | hantavirus pulmonary syndrome (hps) is a rodentborne viral disease characterized by severe pulmonary illness and a case-fatality ratio of 43%. sin nombre virus is the primary hantavirus that causes hps in the united states, and the deer mouse (peromyscus maniculatus) is its predominant carrier. cdc-sponsored studies of rodent populations since 1994 have yielded data that suggest an increased risk for infection for humans in some areas of the southwestern united states during the summer of 1999. ... | 1999 | 10401910 |
| [increased travelling--increased risk of imported viruses. a review of the diagnostic capacity of the swedish institute for infectious disease control]. | the increase in global travel, especially by air, has facilitated the spread of infectious agents from one part of the world to another. returning travellers are often vectors for viral disease import to sweden. while dengue fever has been quite frequently diagnosed during the past five years, especially in travellers returning from thailand, only isolated cases of sandfly fever, japanese encephalitis and ross river fever have been seen. dobrava virus was recently shown to have caused a severe f ... | 1999 | 10405531 |
| hantavirus (bunyaviridae) infections in rodents from orange and san diego counties, california. | 1999 | 10674658 | |
| hantavirus infections in rodents | 1999 | 10674659 | |
| hantavirus pulmonary syndrome (hps) in guariba, sp, brazil. report of 2 cases. | human infections caused by a hantavirus were reported in different regions of the state of são paulo (sp), brazil during the first six months of 1998. two cases of fatal pulmonary syndrome occurred in may of 1998 in the city of guariba, located in the northeastern region of sp. both patients worked in a corn storage barn infested by rodents. these patients, after 2 or 3 days of non-specific febrile illness, developed a severe interstitial pneumonia spreading widely in both lungs, causing respira ... | 1999 | 10413962 |
| antibody responses in humans to an inactivated hantavirus vaccine (hantavax). | hantaviruses cause haemorrhagic fever with renal syndrome (hfrs) and result in severe human morbidity and mortality. safe and effective vaccines are needed urgently in order to reduce the incidence of human illness. hitherto studies of hantavirus vaccine efficiency have been limited to individuals at low risk of infection. in this study the immune response to an inactivated hantavirus vaccine was measured in 64 human volunteers at high risk of infection by virtue of residence and occupation. 30 ... | 1999 | 10418904 |
| hantavirus infection--haemorrhagic fever in the balkans--potential nephrological hazards in the kosovo war. | 1999 | 10462258 | |
| dobrava virus infection: serological diagnosis and cross-reactions to other hantaviruses. | recent data have shown that dobrava (dob) hantavirus is the cause of severe haemorrhagic fever with renal syndrome (hfrs) in central and eastern europe. to determine whether serological assays need to be based on the homologous viral antigen rather than on closely related hantavirus antigens, acute and convalescent sera from patients with hfrs collected in former yugoslavia were examined for igm and igg to three hantavirus antigens; dob, hantaan (htn) and puumala (puu). focus reduction neutraliz ... | 1999 | 10471023 |
| low ph-induced cytopathic effect--a survey of seven hantavirus strains. | hantaviruses do not produce cytopathic effects (cpe) in cell culture. however, a syncytial cpe can be induced in 7-day cultures of hantavirus growing in vero e6 cells by reduction of the ph to approximately 6.2 using a hepes based buffer. the appearance of this acid induced cpe was examined for seven different hantavirus strains. the differences noted were striking and reflected the taxonomic differences between hantaviruses. at 10-100 tcid50% the size of syncytial foci was very large for seoul ... | 1999 | 10488778 |
| acute polyarthritis associated with hantavirus infection. | 1999 | 10489233 | |
| temporal and spatial analysis of sin nombre virus quasispecies in naturally infected rodents. | sin nombre virus (snv) is thought to establish a persistent infection in its natural reservoir, the deer mouse (peromyscus maniculatus), despite a strong host immune response. snv-specific neutralizing antibodies were routinely detected in deer mice which maintained virus rna in the blood and lungs. to determine whether viral diversity played a role in snv persistence and immune escape in deer mice, we measured the prevalence of virus quasispecies in infected rodents over time in a natural setti ... | 1999 | 10516063 |
| acute infection with sin nombre hantavirus without pulmonary edema. | acute infection with sin nombre virus has been associated with development of hantavirus cardiopulmonary syndrome (hcps), a severe cardiopulmonary illness with respiratory failure and shock. we present two cases of sin nombre hantavirus infections that did not lead to marked pulmonary complications in two otherwise healthy young adults from utah and california. sin nombre virus causes a wider spectrum of disease severity than has been previously reported. | 1999 | 10530462 |
| genetic investigation of novel hantaviruses causing fatal hps in brazil. | although hantavirus pulmonary syndrome (hps) was discovered in north america in 1993, more recent investigations have shown that the disease is a much larger problem in south america, where a greater number of cases and hps-associated viruses have now been detected. here we describe the genetic investigation of three fatal hps cases from brazil, including a 1995 case in castelo dos sonhos (cas) in the state of mato grosso and two 1996 cases in the counties of araraquara (ara) and franca (fra), i ... | 1999 | 10534737 |
| rapidly evolving adult respiratory distress syndrome with eosinophilia of unknown cause in previously healthy active duty soldiers at an army training center: report of two cases. | two previously healthy soldiers presented with rapidly evolving adult respiratory distress syndrome (ards) within days of their return from the national training center at fort irwin, california. there have been six similar cases reported in the national training center area, five with fatal outcomes. | 1999 | 10628168 |
| high levels of viremia in patients with the hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome (hps) is a rare but acute fulminant disease caused by sin nombre virus (snv). to understand the role of the viral load in the pathogenesis of hps, the load of virus in the blood of patients with hps was measured. a quantitative reverse transcription-polymerase chain reaction assay was developed for snv, because snv is difficult to grow in cell culture. thirty-eight samples from 26 patients with hps were analyzed. twenty of the 26 initial samples were positive for vi ... | 1999 | 10558964 |
| isolation and genetic characterization of a hantavirus (bunyaviridae: hantavirus) from a rodent, oligoryzomys microtis (muridae), collected in northeastern peru. | this paper describes the isolation and partial genetic characterization of a hantavirus from a pygmy rice rat, oligoryzomys microtis, collected within the urban area of iquitos, loreto department, peru. the virus, designated htn-007, exhibited the highest degree of genetic similarity to rio mamore virus, which was originally described from the same rodent species in eastern bolivia. comparison of small and medium segment nucleotide sequence data from htn-007 and rio mamore virus revealed 87% and ... | 1999 | 10432063 |
| hantavirus infections: epidemiology and pathogenesis. | hantaviruses are enveloped rna viruses that persistently infect rodent hosts without ill-effect. the host persistently excretes virus in urine and saliva. man becomes infected from the rodents when one enters the ecological niche of the other. there are two major clinical presentations--haemorrhagic fever with renal syndrome, found worldwide in various forms and hantavirus pulmonary syndrome, found only in the americas. this review examines the virology, epidemiology and pathogenesis of these em ... | 1999 | 10580279 |
| a case-control study after a hantavirus infection outbreak in the south of belgium: who is at risk? | puumala is the most common hantavirus serotype in europe and is spread mainly by the red bank vole. between 1 july 1992 and 31 january 1994, an outbreak of puumala virus-induced nephropathia epidemica (ne) occurred in the belgian ardennes. serologically confirmed cases (n = 41) were compared with two groups of asymptomatic seronegative controls. risks identified included sighting of living rodents, exposure to rodent droppings, and trapping rodents during the 4 weeks preceding onset of symptoms. ... | 1999 | 10825047 |
| hemorrhagic fever with renal syndrome in the dolenjska region of slovenia--a 10-year survey. | this report describes the first investigation of clinical findings for a larger series of patients with hemorrhagic fever with renal syndrome (hfrs) who were infected with dobrava virus. from 1985 to 1995, 38 patients with serologically confirmed hfrs were hospitalized at the regional hospital in novo mesto in the dolenjska region of slovenia. on the basis of results of serological examination, 24 patients had dobrava virus infection, and 14 patients had puumala virus infection. complete clinica ... | 1999 | 10825051 |
| phage-displayed peptides mimicking the discontinuous neutralization sites of puumala hantavirus envelope glycoproteins. | we selected peptide ligands mimicking the surface structure of discontinuous binding sites of puumala hantavirus-neutralizing monoclonal antibodies from a random 18-amino acid peptide library containing a disulfide bridge in a fixed position and displayed on a filamentous phage. the varying of selection conditions, either by shortening of the association time or by competitive elution with antigen, was crucial for the selection of peptide inserts that could be aligned with the primary sequences ... | 1999 | 10502511 |
| update: hantavirus pulmonary syndrome--united states, 1999. | 1999 | 10510528 | |
| chronic renal failure after puumala virus infection. | chronic renal failure has never been described after puumala hantavirus infection, which usually causes acute renal failure with spontaneous full recovery. we report a 15-year-old boy who presented with puumala hantavirus infection and initial severe acute renal failure. his renal function gradually improved, but more than 2 years after the acute episode it was still moderately impaired, with a creatinine clearance of about 60 ml/min per 1.73 m(2) | 1999 | 10603154 |
| superovulation in vesper mice, calomys laucha--an important biomedical model for hantavirus and arenavirus (rodentia-sigmodontinae). | sigmodontine rodents are poorly studied and have not received much attention as a reproductive model. renewed interest in the south american rodents has been stimulated by their link to endemic diseases that are transmitted to man. calomys laucha acts as a reservoir of two dangerous viruses: an arenavirus named 'junin virus', the aetiological agent of argentinian haemorrhagic fever, and the hantavirus, both of which constitute serious sanitary problems. the aim of this study was to establish sui ... | 1999 | 10778786 |
| [hantavirus in chile: review and cases analysis since 1975]. | since the identification of the first case of hantavirus infection in chile in 1995, a great advance in the knowledge of the disease natural history has occurred. there is evidence to suppose that the infection by andes virus in suburban areas of argentina and chile, whose natural reservoir is oligoryzomys longicaudatus, has been present but unidentified for a long time. we describe a serologically proven case occurred in 1975. the clinical presentation of the disease slightly differs from that ... | 1999 | 10835761 |
| hantavirus pulmonary syndrome: an alert to latin american countries. | approximately 400 cases of hantavirus pulmonary syndrome (hps) have been reported on the north american continent since the first epidemic in 1993, in new mexico, usa. in brazil, 12 cases were confirmed before 1998. infection results from inhalation of rodent blood, saliva or waste. clinical findings of the disease are characterized by a nonspecific febrile illness, followed by rapid progression to pulmonary edema which may lead to a shock-like state or renal failure. mortality is high and emerg ... | 1999 | 11084670 |
| epidemiological progresses of hemorrhagic fever with renal syndrome in china. | to summarize the major achievements of chinese work on the epidemiology and prevention of hemorrhagic fever with renal syndrome (hfrs) in recent years, and to give a general review on the present situation of hfrs in china. | 1999 | 11593522 |
| [the pathogenicity of hfrs patient's soft palate mucosa to suckling mice]. | to explore the pathogenic mechanism of hemorrhagic fever with renal syndrome(hfrs). | 1999 | 12759963 |
| hantavirus pulmonary syndrome in the americas: the early years. | the initial recognition of hantavirus pulmonary syndrome (hps) as a new disease associated with a cluster of acute respiratory deaths among american indians in the southwestern united states in 1993 bears little resemblance to the current understanding of this syndrome. hps is now recognized as a zoonotic disease that has been endemic throughout the americas for at least 40 years and that is closely linked to population densities and virus dynamics among a specific subfamily of rodents. the clas ... | 2000 | 16088742 |
| [febrile cytolysis disclosing hemorrhagic fever with renal syndrome]. | we report the case of a 40-year-old-man who developed febrile cytolysis as the presenting sign of hemorragic fever with renal syndrome (hfrs). on admission, he had fever (40 degrees c) and epigastric pain. the ast level was at 2n, the alt at 3n. there was a thrombocytopenia (61 000/mm(3)) without anemia or hyperleukocytosis. three days after admission, the platelet count decreased to 40 000/mm(3), serum urea and creatinine increased from normal rate to 10.8mmol/l, 204.0 micromol/l, respectively. ... | 2000 | 11173712 |
| the incubation period of hantavirus pulmonary syndrome. | in 1993 sin nombre virus was recognized as the cause of hantavirus pulmonary syndrome (hps) and the deer mouse (peromyscus maniculatus) was identified as the reservoir host. surveillance by the centers for disease control and prevention and state health departments includes investigation to determine the likely site(s) and activities that led to infection, an environmental assessment of the home and workplace, and possibly rodent trappings at these sites. as of december 31, 1998, there were 200 ... | 2000 | 11304061 |
| hantavirus infections. | hantaviruses are the causative agents of the zoonotic diseases known as haemorrhagic fever with renal syndrome (hfrs) in europe and asia, and hantavirus pulmonary syndrome (hps) in the americas. these pathogens are maintained in the wild by rodent reservoirs and are mainly transmitted via the aerosol route. the infection is chronic and apparently asymptomatic in host animals. whilst hfrs is caused by hantaan, seoul, dobrava and puumala hantaviruses, hps is associated with sin nombre-like viruses ... | 2000 | 11189727 |
| [nephropathia epidemica and other hanta virus infections: how rodents' viruses cause disease in human?]. | 2000 | 11764460 | |
| [microbiological surveillance: viral hemorrhagic fever in central african republic: current serological data in man]. | an investigation was conducted between 1994 and 1997 in forested areas of the central african republic (car) to determine the seroprevalence of igg antibodies against several haemorrhagic fever viruses present in the region. sera were obtained from 1762 individuals in two groups (pygmy and bantu locuted populations) living in 4 forested areas in the south of the country. sera were tested for igg antibodies against ebola, marburg, rift valley fever (rvf), yellow fever (yf) and hantaviruses by enz ... | 2000 | 11775321 |
| [study on the genetic difference of seo type hantaviruses]. | to understand the genetic type of hantaviruses and the difference between them caused by rodents in beijing and to furhter explore the source of the infectious factors. | 2000 | 11860814 |
| [safety and immunogenicity of inactivated bivalent ehf vaccine in humans]. | safety and immunogenicity of inactivated bivalent ehf vaccine in humans were evaluated in the epidemic area of zhejiang province, china. | 2000 | 11860832 |
| effects of tumor necrosis factor alpha on sin nombre virus infection in vitro. | previous data indicate that immune mechanisms may be involved in developing capillary leakage during sin nombre virus (snv) infection. therefore, we investigated production of tumor necrosis factor alpha (tnf-alpha) by human alveolar macrophages and human umbilical vein endothelial cells (huvec) after infection with snv. in addition, we examined the effect of tnf-alpha on huvec monolayer leakage. our results reveal that although tnf-alpha decreases accumulation of viral nucleoproteins, tnf-alpha ... | 2000 | 11090198 |
| [prevalence of anti-hantavirus antibodies in health care personnel in direct contact with patients with hantavirus pulmonary syndrome in temuco, chile 1997 to 1999]. | an outbreak of hantavirus cardiopulmonary syndrome (hvcs) caused by the andes virus, affected chile since 1995. antibodies to hantavirus in health care workers who had cared patients with hvcs in coybaique, argentinean reports and familial clustering of bantaviral illness, raised the possibility of person to person transmission. familial clustering could occur secondary to a similar exposure to a common infected environment of more than one member of the family. moreover, the prevalence of antib ... | 2000 | 11050834 |
| [detection for anti-hantavirus igm in patient serum with silver enhanced dot immunogold filtration assay]. | to establish a more rapid and simple method for detecting anti-hantavirus igm in patient' s serum. | 2000 | 11498694 |
| [the partial nucleotide sequence of l segment of hantavirus strain]. | to study the nucleotide sequence of l segment of hantavirus strain a9. | 2000 | 11503036 |
| hantavirus update on an emerging--and lethal--infectious disease. | 2000 | 11503410 | |
| [discovery of a new subtype of seo virus]. | the m and s segments of cou3, a hantavirus strain isolated from rattus norvegieus were partially reverse transcripted, pcr amplified and sequenced with abi 373 dna sequencer to observe the differences from other seo type viruses. | 2000 | 11471015 |
| antigenic properties and diagnostic potential of recombinant dobrava virus nucleocapsid protein. | dobrava hantavirus (dobv) causes severe hemorrhagic fever with renal syndrome in the balkan region and has been detected recently also in russia, estonia, and germany. dobv nucleocapsid protein (n) was produced in insect cells, using the baculovirus expression system (bac-dobv-n), and in e. coli as a truncated (aa 1-165) glutathione-s transferase fusion protein (dobv-dn-gst). the antigenic properties of bac-dobv-n were found identical to native dobv-n when examined by a panel of hantavirus-speci ... | 2000 | 10797384 |
| puumala (puu) hantavirus strain differences and insertion positions in the hepatitis b virus core antigen influence b-cell immunogenicity and protective potential of core-derived particles. | hepatitis b virus (hbv) core-derived chimeric particles carrying a puumala (puu) hantavirus (strain vranica/hällnäs) nucleocapsid (n) protein sequence (aa 1-45), alternatively inserted at three distinct positions (n-, c-terminus, or the internal region), and mosaic particles consisting of hbv core as well as core/puu (vranica/hällnäs) n (aa 1-45) readthrough protein were generated. chimeric particles carrying the insert at the n-terminus or the internal region of core induced some protective imm ... | 2000 | 11040127 |
| emerging viral diseases. | 2000 | 11035785 | |
| tracing dobrava hantavirus infection. | 2000 | 10837207 | |
| [hantavirus pulmonary syndrome in southern argentina]. | andes virus was identified in 1995 as the etiologic agent of hantavirus pulmonary syndrome (hps) in southern argentina. we describe herein the main clinical characteristics of 25 hps confirmed cases acquired in this area between 1993 and september 1999. the mean age was 34 years (range 11-70), with 72% males. clinical characteristics were similar to those previously reported for sin nombre virus (snv) cases. however, in this group of patients we also observed conjuntival injection in 10/25 (42%) ... | 2000 | 11050803 |
| pronounced monocytosis in a case of nephropathia epidemica. | nephropathia epidemica is a mild form of haemorrhagic fever with renal syndrome. thrombocytopenia is common and characteristic. we report here a case of a young man with nephropathia epidemica and marked transient monocytosis. | 2000 | 10959653 |
| hantavirus pulmonary syndrome in canada, 1989-1999. | 2000 | 10851764 | |
| first case of puumala virus infection in greece. | 2000 | 11073146 | |
| genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of russia. | to identify the hantaviruses causing hemorrhagic fever with renal syndrome (hfrs) in the far east of russia, blood samples collected from hfrs patients in 1994-1998, were examined by reverse transcription-polymerase chain reaction. in addition, 36 sera were tested by an immunofluorescence assay for antibodies against hantaan, seoul, puumala, and khabarovsk viruses, and 54 samples were tested by plaque reduction neutralization test. with both serological assays, the highest antibody titers were t ... | 2000 | 11074123 |
| the epidemiology of nephropathia epidemica in finland: clinical diagnosis vs. serological diagnosis. | 2000 | 10959667 | |
| preliminary characterization and natural history of hantaviruses in rodents in northern greece. | 2000 | 11076727 | |
| experimental infection model for sin nombre hantavirus in the deer mouse (peromyscus maniculatus). | the relationship between hantaviruses and their reservoir hosts is not well understood. we successfully passaged a mouse-adapted strain of sin nombre virus from deer mice (peromyscus maniculatus) by i.m. inoculation of 4- to 6-wk-old deer mouse pups. after inoculation with 5 id(50), antibodies to the nucleocapsid (n) antigen first became detectable at 14 d whereas neutralizing antibodies were detectable by 7 d. viral n antigen first began to appear in heart, lung, liver, spleen, and/or kidney by ... | 2000 | 10973478 |
| [hantavirus disease during pregnancy]. | hantavirus infection is known to occur in mice and rats without symptoms. in contrast, an infection with hantavirus in humans gives influenzalike symptoms and acute renal failure. the treatment is symptomatic, but treatment with dialysis can be necessary for a while. a case of hantavirus infection in denmark in a 30 week pregnant woman is reported. | 2000 | 11043050 |
| molecular evolution of puumala hantavirus in fennoscandia: phylogenetic analysis of strains from two recolonization routes, karelia and denmark. | like other members of the genus hantavirus: in the family bunyaviridae:, puumala virus (puuv) is thought to be co-evolving with its natural host, the bank vole clethrionomys glareolus. to gain insight into the evolutionary history of puuv in northern europe during the last post-glacial period, we have studied wild-type puuv strains originating from areas along two postulated immigration routes of bank voles to fennoscandia. full-length sequences of the s rna segment and partial sequences (nt 216 ... | 2000 | 11086113 |
| seroprevalence of human hantavirus infection in the ribeirão preto region of são paulo state, brazil. | 2000 | 10998393 | |
| genetic analysis of wild-type dobrava hantavirus in slovenia: co-existence of two distinct genetic lineages within the same natural focus. | genetic analysis was performed of wild-type (wt) dobrava hantavirus (dob) strains from slovenia, the country where the virus was first discovered and where it was found to cause haemorrhagic fever with renal syndrome (hfrs), with a fatality rate of 12%. two hundred and sixty mice of the genus apodemus:, trapped in five natural foci of dob-associated hfrs during 1990-1996, were screened for the presence of anti-hantavirus antibodies and 49 apodemus: flavicollis and four apodemus: agrarius were fo ... | 2000 | 10859380 |
| complement activation in nephropathia epidemica caused by puumala hantavirus. | nephropathia epidemica (ne) is a hemorrhagic fever with renal syndrome caused by puumala hantavirus. there is considerable variability in the clinical severity of ne. its pathogenesis is largely unknown and data on complement activation in ne are scant. we sought here to establish how the complement system behaves during ne and whether the variation in the clinical outcome is related to the activation of complement. | 2000 | 10879661 |
| hantaviruses. | since the recognition of the hantavirus pulmonary syndrome (hps) in the usa in 1993, interest in hantavirus diseases has intensified worldwide. it is clear that hantaviruses have been historically responsible for a variety of human illnesses. hantaviruses form a separate genus within the bunyaviridae family. there are currently >20 recognised sero/genotypes and many others are under investigation. each hantavirus type appears to be specific to a different rodent host. virus phylogeny very closel ... | 2000 | 10882083 |
| genetic diversity of hantaviruses isolated in china and characterization of novel hantaviruses isolated from niviventer confucianus and rattus rattus. | the antigenic and genetic properties of 46 hantaviruses from china, 13 from patients, 23 from rodents, and 10 from unknown hosts, were compared with those of other hantaviruses. the viruses were classified as either hantaan (htn) or seoul (seo) viruses. a phylogenetic analysis of the partial m (300 bp) and s (around 485 bp) genomes of htn viruses identified nine distinct genetic subtypes, one consisting of isolates from korea. the seo viruses were divided into five genetic subtypes, although the ... | 2000 | 11118357 |
| humoral immune responses in the hantavirus cardiopulmonary syndrome. | the immunologic responses that mediate viral clearance of and recovery from hantavirus cardiopulmonary syndrome (hcps) due to sin nombre (sn) virus are unknown. serial serum samples from 26 patients with acute sn virus infection were tested for igg, iga, and igm reactivity to recombinant viral nucleocapsid (n) and glycoprotein g1 antigens by a novel strip immunoblot assay. the titers of antibodies capable of neutralizing sn virus in vitro also were determined for each sample. at admission, patie ... | 2000 | 10882580 |
| genetic analysis of sin nombre hantavirus in iowa. | 2000 | 10783030 | |
| renal failure and hantavirus infection in europe. | 2000 | 10831620 | |
| dual captures of colorado rodents: implications for transmission of hantaviruses. | we analyzed dual-capture data collected during longitudinal studies monitoring transmission and persistence of sin nombre virus in rodents in colorado. our data indicate that multiple captures (two or more rodents captured in a single trap) may not be random, as indicated by previous studies, but rather the result of underlying, species-specific social behavior or cohesiveness. in the pairs we captured, most often, rodents were of the same species, were male, and could be recaptured as pairs. th ... | 2000 | 10970147 |
| [outbreak of hemorrhagic fever with kidney syndrome in egor'ev district of moscow region]. | epizootological, serological, and molecular virological analysis of an outbreak of hemorrhagic fever with renal syndrome (hfrs) in the egoryevsk district of moscow region (september 1995-january 1996) has been carried out. hantavirus (puumala) antigen and virus-specific antibodies were isolated from bank voles captured in the endemic focus. anti-puumala antibodies were detected in the sera of all hfrs patients and in 2% healthy residents of the endemic focus. analysis of nucleotide sequence (rna ... | 2000 | 10971964 |
| diagnostic potential of puumala virus nucleocapsid protein expressed in drosophila melanogaster cells. | puumala virus (puu) nucleocapsid protein (n) was expressed in insect cells by using the drosophila expression system (des; invitrogen bv, groningen, the netherlands). stable transfectants were established by hygromycin b selection and showed continuous expression of the recombinant protein (des-puu-n) for at least 5 months. the antigenic property of des-puu-n was shown to be identical to that of native puu n when examined with a panel of hantavirus-specific monoclonal antibodies. enzyme-linked i ... | 2000 | 10834996 |
| [epidemiologic problems in hantavirus infections]. | the objective of the submitted paper was to present some information pertaining to epidemiological problems of hantavirus infection. in the czech republic the prevalence of these infections is not alarming but in the world cases of haemorrhagic fever with renal syndrome (hfrs) as well as hantavirus pulmonary syndrome (hps) are reported. on the territory of the czech republic there are foci of hantaviruses and in conjunction with summer tourism or working activities abroad the import of this infe ... | 2000 | 10802945 |
| pathogenicity of hantaan virus in newborn mice: genetic reassortant study demonstrating that a single amino acid change in glycoprotein g1 is related to virulence. | two hantaan virus strains, clone 1 (cl-1), which is virulent in newborn mice, and its attenuated mutant (mu11e10), were used to examine the pathogenesis of hantaan virus infection in a mouse model and identify virus factors relating to virulence. after subcutaneous inoculation of newborn balb/c mice, cl-1 caused fatal disease with high viral multiplication in peripheral organs, but mu11e10 produced nonfatal infection with a low level of virus multiplication. intracerebral inoculation of either s ... | 2000 | 10982372 |
| evaluation of two commercially available immunoassays for the detection of hantavirus antibodies in serum samples. | hantaviruses are members of the family bunyaviridae and the spectrum of clinical symptoms in humans may vary from sub-clinical to severe haemorrhagic fever with renal syndrome (hfrs) or pulmonary syndrome (hps). several serotypes have been described from which at least five are pathogenic to humans. each serotype has a different animal reservoir and geographical distribution. in the acute phase of the disease the clinical diagnosis may be confirmed by serology or by polymerase-chain reaction (pc ... | 2000 | 10996116 |
| immunoglobulin a responses to puumala hantavirus. | puumala hantavirus (puuv) causes nephropathia epidemica (ne), a form of haemorrhagic fever with renal syndrome that occurs in northern and central europe. the immunoglobulin a (iga) response in ne patients was studied. the levels of total serum iga in acute-phase samples from ne patients were found to be significantly elevated when compared with the levels in healthy controls. elisas for detection of the iga1 and iga2 responses against each puuv structural protein (n, g1 and g2) were developed a ... | 2000 | 10811929 |
| outbreak of hantavirus infection in the four corners region of the united states in the wake of the 1997-1998 el nino-southern oscillation. | hantavirus cardiopulmonary syndrome (hcps), a rodent-borne zoonosis, has been endemic in the americas for at least several decades. it is hypothesized that the 1991-1992 el niño-southern oscillation (enso) caused increased precipitation that allowed an increase in rodent population densities, thereby increasing the possibility of transmission to humans. the result was a 1993-1994 outbreak of the disease in the four corners states of the southwestern united states. a second strong enso occurred i ... | 2000 | 10823755 |
| clinical aspects of nephropathia epidemica (puumala virus infection) in europe: a review. | nephropathia epidemica (ne) is a prevalent zoonosis throughout europe and is caused by the puumala type of hantavirus. the incidence of ne varies in a cyclic fashion, with peaks occurring every 3rd to 4th year, coinciding with peaks in vole populations. the clinical course of ne is generally milder than haemorrhagic fever with renal syndrome caused by hantaviruses in other parts of the world. typically, ne has a sudden onset with fever, headache, backpain and gastrointestinal symptoms. however, ... | 2000 | 10826895 |
| evolutionary diversification of protein-coding genes of hantaviruses. | phylogenetic analyses of the s:, m, and l: genes of the hantaviruses (bunyaviridae: hantavirus) revealed three well-differentiated clades corresponding to viruses parasitic on three subfamilies (murinae, arvicolinae, and sigmodontinae) of the rodent family muridae. in rooted trees of m: and l: genes, the viruses with hosts belonging to murinae formed an outgroup to those with hosts in arvicolinae and sigmodontinae. this phylogeny corresponded with a phylogeny of the murid subfamilies based on mi ... | 2000 | 11018161 |
| using remotely sensed data to identify areas at risk for hantavirus pulmonary syndrome. | the 1993 u.s. hantavirus pulmonary syndrome (hps) outbreak was attributed to environmental conditions and increased rodent populations caused by unusual weather in 1991- 92. in a case-control study to test this hypothesis, we estimated precipitation at 28 hps and 170 control sites during the springs of 1992 and 1993 and compared it with precipitation during the previous 6 years by using rainfall patterns at 196 weather stations. we also used elevation data and landsat thematic mapper satellite i ... | 2000 | 10827113 |
| [serological diagnosis and nasopharyngeal washings in pediatric infections]. | in the course of respiratory infections, the efficacy of microbiologic diagnosis has increased years after years, in term of specificity, sensitivity and rapidity. new pathogenic agents have been described such as: legionella pneumophila, chlamydia pneumoniae, hantavirus. some viruses have been well characterized as responsible for seasonal outbreaks using rapid tools for identification. needs for efficient diagnostic tools became more obvious when specific antiviral drugs appeared on the market ... | 2000 | 11028183 |
| remote sensing and geographic information systems: charting sin nombre virus infections in deer mice. | we tested environmental data from remote sensing and geographic information system maps as indicators of sin nombre virus (snv) infections in deer mouse (peromyscus maniculatus) populations in the walker river basin, nevada and california. we determined by serologic testing the presence of snv infections in deer mice from 144 field sites. we used remote sensing and geographic information systems data to characterize the vegetation type and density, elevation, slope, and hydrologic features of ea ... | 2000 | 10827114 |
| accumulation of terminally deleted rnas may play a role in seoul virus persistence. | two independent, long-term infections were analyzed to determine whether changes in viral replication could contribute to the establishment and/or maintenance of persistent seoul virus infections. infected cell cultures initially contained high levels of infectious virus and intracellular viral rna that peaked between approximately 7 to 16 days postinfection and then gradually declined until day 26. after day 26, the viral titers and the levels of the small (s), medium (m), and large (l) viral r ... | 2000 | 10627543 |
| [clinical case of the month. a new case of nephropathia epidemica due to puumala virus]. | nephropathia epidemica due to puumala virus has already been described in belgium. its evolution is usually favourable. the main symptoms are fever, a decrease platelet count, proteinuria and acute renal insufficiency, which, in an epidemiological context, quickly point the correct diagnosis. acute and transitory myopia is typical. nevertheless, the clinical presentation, including multisystemic symptoms may lead to the false diagnosis of an acute bacterial or immune disease. | 2000 | 10769579 |
| annual update of systemic disease--1999: emerging and re-emerging infections (part ii). | 2000 | 10770510 |