Publications

[emerging infectious diseases--hantavirus infections].		1997	9480304
isolation, characterization and geographic distribution of caño delgadito virus, a newly discovered south american hantavirus (family bunyaviridae).	rodents collected from the venezuelan llanos (plains) during field studies of viral hemorrhagic fever were tested for evidence of hantavirus infection. hantavirus antibody was found in one (7.7%) of 13 oryzomys bicolor, one (3.4%) of 29 rattus rattus, 10 (6.0%) of 166 sigmodon alstoni and one (2.2%) of 45 zygodontomys brevicauda. hantavirus-specific rna was detected in lung tissues from four antibody-positive rodents: two s. alstoni from portuguesa state and one s. alstoni each from cojedes and ...	1997	9498614
human-to-human transmission of hantaviruses.		1997	9284808
[approaches to selecting a strain of hantavirus for developing an inactivated brain vaccine].	four strains isolated from patients with hemorrhagic fever with the renal syndrome and from field mice, natural hosts of hantavirus, were examined in order to choose a functionally active strain fit for the development of inactivated hantavirus brain vaccine. virulent strain pm-10508/89 isolated from mouse lungs was chosen. the strain was highly virulent for newborn mice and rats: 100% of infected mice aged up to 24 h and 75% of rats developed an acute lethal infection upon challenge. the incuba ...	1997	9297337
dobrava hantavirus outbreak in russia.		1997	9298001
puumala and dobrava viruses cause hemorrhagic fever with renal syndrome in bosnia-herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera.	hantavirus infection was diagnosed serologically by mu-capture igm and igg elisas in hemorrhagic fever with renal syndrome (hfrs) patients admitted to tuzla hospital, bosnia-herzegovina. the results indicated that more than one hantavirus caused the outbreak. to address the question of which hantavirus serotypes were involved, sequentially drawn sera were analyzed by focus reduction neutralization test (frnt) for antibodies against puumala, hantaan, dobrava, and seoul hantaviruses. the data reve ...	1997	9298732
[the ecological aspects of the epidemiology of hemorrhagic fever with renal syndrome in the south of the far east in russia].	the data on the relationship between the epizootic process in the population of mice (the source of hantavirus infection) and the seasonal manifestations of morbidity in hemorrhagic fever with renal syndrome (hfrs) in the southern region of the russian far east are presented. the asynchronous course of the epizootic process in the population of rodents causes irregularity in the spread of hfrs in the region and periodicity in the appearance of foci. seasonal rises in hfrs morbidity coincide with ...	1997	9304320
an outbreak of hantavirus pulmonary syndrome in western paraguay.	during an investigation of hantavirus pulmonary syndrome (hps) in paraguay in 1995, sera from persons with hps-like illness, houshold contacts of confirmed hps case-patients, and a sample of the area residents were analyzed by elisa for antibodies to sin nombre virus (snv). rodent serosurveys and analysis of precipitation records were also conducted. twenty-three of 24 available probable cases were snv antibody-positive, 17 of whom were ill between july 1995 and january 1996. four (14.8%) of 27 ...	1997	9311636
rio mamore virus: genetic characterization of a newly recognized hantavirus of the pygmy rice rat, oligoryzomys microtis, from bolivia.	human hantavirus disease occurs throughout much of south america. the rodent hosts and the specific etiologic agent(s) are largely unknown, but many reported cases occurred within the habitation ranges of oryzomine rodents (rice rats). we have identified a genetically novel hantavirus (rio mamore virus [rm]) of the pygmy rice rat oligoryzomys microtis in bolivia. the complete sequence of the small (s) genome and the partial sequence of the medium (m) genome are described. this virus is closely r ...	1997	9311652
a colorimetric pcr-enzyme immunoassay to identify hantaviruses.	hantaviruses cause two serious human diseases: hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. at least nine hantaviruses are known to be pathogenic for humans and numerous others, with unknown disease potential, have been detected in rodents. assays to quickly identify specific hantaviruses would be useful both for clinical diagnosis and in risk assessment studies.	1997	9316733
epitope mapping by phage display: random versus gene-fragment libraries.	we present a comparative study on epitope mapping of four monoclonal antibodies directed against four different antigens using alternative phage display techniques and peptide scanning: mab215 reacts with the largest subunit of rna polymerase ii, mabbp53-11 with the tumor suppressor protein p53, mabgdo5 with the hantaan virus glycoprotein g2 and mabl13f3 with the hantaan virus nucleocapsid protein. epitopes were determined (i) by gene-fragment phage display libraries, constructed by dnasei diges ...	1997	9328567
role of electron microscopy in interstitial lung disease.	although electron microscopy no longer enjoys the important role in the diagnosis of interstitial lung diseases that it had in the 1960s and 1970s, it remains an important adjunct in the differential diagnosis of certain pulmonary diseases. examples include various manifestations of systemic lupus erythematous pneumonitis, in which the presence of tubuloreticular structures and electron-dense deposits are useful for diagnosis; immotile cilia disorders, in which qualitative and now quantitative s ...	1997	9331535
the first human isolate of puumala virus in scandinavia as cultured from phytohemagglutinin stimulated leucocytes.	a virus isolate was recovered from blood leucocytes of a patient with nephropathia epidemica (ne). leucocytes were isolated from edta-blood by dextran sedimentation and cultured on monolayers of vero e6 cells in the presence of phytohemagglutinin (pha) in roller tubes during the first 72 hours of incubation followed by rolling culture for three weeks in total. thereafter the first subculture was done in a plastic flask and afterward at at least 6 week intervals. antigen was first detected after ...	1997	9334926
puumala virus and two genetic variants of tula virus are present in austrian rodents.	puumala and tula viruses are hantaviruses found in europe and are associated with the rodents clethrionomys glareolus and microtus arvalis, respectively. puumala virus is associated with the human disease nephropathia epidemica. in austria, ten clinically diagnosed cases of nephropathia epidemica, presumably caused by puumala virus infection, have been reported but not virologically confirmed [leschinskaya et al., 1991; aberle et al., 1996]. to identify the hantaviruses that are present in austr ...	1997	9334930
effectiveness of recorded messages to communicate the risk of acquiring hantavirus pulmonary syndrome.	to determine the effectiveness of a recorded information line in communicating health risk during the emergence of a new disease, hantavirus pulmonary syndrome (hps), in the edmonton area and to study the accuracy of recall of information about hantavirus among the general public.	1997	9336097
hantavirus pulmonary syndrome -- chile, 1997.	hantavirus pulmonary syndrome (hps) was first recognized in chile in october 1995; through july 1997, nine cases had been identified in the country. however, during august 1-october 8, 1997, a total of 12 persons with hps, including two family clusters, were recognized. a collaborative investigation is under way to determine the magnitude of this outbreak, the associated rodent reservoir for hantaviruses, and the major risk factors for human infection. this report summarizes the preliminary resu ...	1997	9338456
hantavirus pulmonary syndrome in the americas.		1997	9341305
glomerular basement membrane antibodies in hantavirus disease (hemorrhagic fever with renal syndrome).	the prevalence of antibodies against glomerular basement membrane (gbm) antigens in sera from 47 patients with serologically verified hantavirus (puumala serotype) infection were investigated. antibodies were measured by immunoassays using as antigen a crude human gbm preparation and the nc1 portion of type iv collagen (goodpasture antigen), respectively. seventy-seven percent of the patients had igm antibodies against the non-goodpasture glomerular basement membrane (non-gp gbm) in their acute ...	1997	9342483
isolation, genetic diversity, and geographic distribution of bayou virus (bunyaviridae: hantavirus).	bayou hantavirus, previously implicated in human hantavirus pulmonary syndrome in louisiana, was isolated from a rice rat (oryzomys palustris) captured in georgia. the presence of antibody among rice rats captured throughout the southeastern united states and the extent of diversity among the genetic variants of bayou viruses suggest that the rice rat is the most likely natural reservoir of the virus and that both virus and host have probably co-evolved for some years.	1997	9347961
nephropathia epidemica infection during first trimester of pregnancy--normal fetal outcome.		1997	9351417
papillary necrosis: a late complication of nephropathia epidemica?	in the following we describe a case of nephropathia epidemica, which exhibited, a few years after acute infection, arterial hypertension and multiple papillary necrosis. papillary necrosis was diagnosed by i.v. pyelography and ct scan. a complete evaluation of the patient failed to show any other etiology for medullary necrosis. if arterial hypertension has already been reported as a complication of nephropathia epidemica, papillary necrosis is exceptional, but may be explained by the severe vas ...	1997	9352163
prevalence of serum antibodies to hantaviruses in northern sweden as measured by recombinant nucleocapsid proteins.	an enzyme-linked immunosorbent assay (elisa) based on recombinant nucleocapsid protein (rn delta) (aa 1-117) of hantaan, seoul, dobrava, sin nombre and puumala hantaviruses was used to determine the prevalence of antibodies among randomized and stratified individuals from northern sweden. in total, 137/1533 individuals (8.9%) had specific serum igg antibodies to puumala virus, the only hantavirus known to occur in the region. the prevalence of antibodies to puumala virus (8.9%) was determined to ...	1997	9360248
hantavirus infection in scid mice.	severe combined immunodeficiency (scid) mice were inoculated with hantaan virus strain 76-118 (htn) or seoul virus strain sr-11 (sr) of hantaviruses. susceptibility of scid mice was compared with those of immunocompetent adult mice, newborn mice and nude mice. scid mice inoculated with htn or sr died 32 to 35 days after infection. unlike newborn mice which also died of hantavirus infection, scid mice survived longer than newborn mice and showed typical wasting symptoms rather than nervous sympto ...	1997	9362032
the investigation of emerging and re-emerging viral diseases: a paradign.	emerging virus infections are defined as previously nonthreatening viruses that can decimate new populations by finding fresh hosts and vectors--often with the help of humans who introduce new species into virgen environment, several etiologic agents of these diseases, some of the interacting factors that contribute to their development and the role of molecular medicine in their understanding is discussed.	1997	9419931
baculovirus expression of a human g2-specific, neutralizing igg monoclonal antibody to puumala virus.	we amplified by polymerase chain reaction the heavy- and light-chain antibody genes of a human hybridoma secreting a neutralizing, igg monoclonal antibody to the g2 protein of puumala virus. the heavy- and light-chain genes were cloned and sequenced and the deduced amino acids were aligned with those of other human antibodies to identify the constant and variable regions. the genes were cloned into the baculovirus plasmid transfer vector pacuw51 such that the heavy-chain and light-chain genes we ...	1997	9281505
[viral haemorrhagic fever].	viral haemorrhagic fever denotes various kinds of febrile illness caused by certain viruses which often presents with bleeding tendency and occasionally shock. out of these, the four maladies, lassa fever, ebola haemorrhagic fever, marburg haemorrhagic fever and crimean-congo haemorrhagic fever which are endemically present in africa or eastern europe, are known to be such diseases with high man-to-man communicability. these four haemorrhagic fevers are, therefore, designated as special conditio ...	1997	9283226
hantavirus transmission in the united states.	in 1996, investigation of a hantavirus pulmonary syndrome (hps) outbreak in southern argentina found evidence of person-to-person transmission of a hantavirus. the infection control ramifications of this finding led to this review of hantavirus epidemiology in the united states; the review suggests that sin nombre virus infection is rarely, if ever, transmitted from person to person and that existing guidelines for prevention of hps remain appropriate for north america.	1997	9284382
population dynamics of the deer mouse (peromyscus maniculatus) and sin nombre virus, california channel islands.	hantavirus pulmonary syndrome, first documented in 1993, is caused by sin nombre virus (snv), which is carried by the peromyscus species. in 1994, high snv antibody prevalence was identified in deer mice from two california channel islands. we sampled two locations on three islands to estimate mouse population density and snv prevalence. population flux and snv prevalence appear to vary independently.	1997	9284383
cell culture adaptation of puumala hantavirus changes the infectivity for its natural reservoir, clethrionomys glareolus, and leads to accumulation of mutants with altered genomic rna s segment.	this paper reports the establishment of a model for hantavirus host adaptation. wild-type (wt) (bank vole-passaged) and vero e6 cell-cultured variants of puumala virus strain kazan were analyzed for their virologic and genetic properties. the wt variant was well adapted for reproduction in bank voles but not in cell culture, while the vero e6 strains replicated to much higher efficiency in cell culture but did not reproducibly infect bank voles. comparison of the consensus sequences of the respe ...	1997	9371614
laguna negra virus associated with hps in western paraguay and bolivia.	a large outbreak of hantavirus pulmonary syndrome (hps) recently occurred in the chaco region of paraguay. using pcr approaches, partial virus genome sequences were obtained from 5 human sera, and spleens from 5 calomys laucha rodents from the outbreak area. genetic analysis revealed a newly discovered hantavirus, laguna negra (ln) virus, to be associated with the hps outbreak and established a direct genetic link between the virus detected in the hps cases and in the c. laucha rodents, implicat ...	1997	9375015
pleural fluid characteristics in hantavirus pulmonary syndrome.	hantavirus pulmonary syndrome (hps), is a rodent-borne, acute, often fulminant cardiorespiratory illness. noncardiogenic pulmonary edema is prominent in hps as is cardiac dysfunction. pleural effusions are commonly noted in patients with hps and have been thought to be exudative. this report describes the prevalence and characteristics of pleural effusions by an assessment of chest radiographs for the presence of pleural fluid and reviews all pleural fluid specimens obtained from patients with h ...	1997	9377934
[epidemic hantavirus nephropathy].		1997	9381000
sequence analysis of the puumala hantavirus sotkamo strain l segment.	sequence of the puumala virus (puu) sotkamo strain l segment is provided, completing the total genome of this prototype puu virus strain. the l segment is 6530 nucleotides long and it can encode 2156 amino-acids-long l protein, rna-dependent rna polymerase. the strain sotkamo, originally isolated in finland, showed for the l genome segment nucleotide (84.6%) and amino acid (97.3%) homology to a previously sequenced puu russian isolate, strain bashkiria/cg1820 (b1820) and the l genome segment app ...	1997	9381791
a small-scale survey of hantavirus in mammals from indiana.	in order to determine if hantaviruses were present in mice and other small mammals in indiana (usa), small mammals were trapped in brown, laporte, tippecanoe and whitley counties. sixty-seven small mammals were trapped during august and september 1994. sixty-three peromyscus leucopus, one microtus pennsylvanicus, one zapus hudsonius and two blarina brevicauda were captured and tested for hantaviruses. six p. leucopus were found to have antibody to sin nombre virus (sn) by igg elisa, and a 139 bp ...	1997	9391967
evaluation of serological methods for diagnosis of puumala hantavirus infection (nephropathia epidemica).	nephropathia epidemica (ne), puumala (puu) virus infection, is a febrile disease which is commonly associated with acute renal impairment. to differentiate ne from other acute febrile illnesses, a rapid and reliable serological diagnosis is important, and a number of different protocols have recently been introduced. in the present report we describe a comparative evaluation of six puu virus immunoglobulin m (igm) and seven igg enzyme-linked immunosorbent assay (elisa) protocols based on native, ...	1997	9399531
hantavirus pulmonary syndrome: cd8+ and cd4+ cytotoxic t lymphocytes to epitopes on sin nombre virus nucleocapsid protein isolated during acute illness.	in 1993 a number of cases of unexplained adult respiratory syndrome occurred in the southwestern united states. the illness was characterized by a prodrome of fever, myalgia, and other symptoms followed by the rapid onset of a capillary leak syndrome with hemoconcentration, thrombocytopenia, and pulmonary edema. viral rna sequences in the lungs identified a new member of the hantavirus genus, sin nombre virus (snv), unique to north america. pulmonary endothelial cells were heavily infected but w ...	1997	9400611
impaired pulmonary function in patients with hemorrhagic fever with renal syndrome.	pulmonary and cardiac functions were investigated in 13 patients hospitalized with nephropathia epidemica, a european form of hemorrhagic fever with renal syndrome. as compared with reference values, the patients' diffusion capacity for carbon monoxide was decreased (p = .002) and pulmonary clearance of inhaled technetium-99m-labeled diethylenetriamine pentaacetic acid was increased (p = .002). in four of 11 patients, arterial blood gas analysis disclosed a reduction in partial pressure of o2 (< ...	1997	9402362
enhancing laboratory detection of disease. part 2: amplifying information and requisite variety.		1997	10172959
enhancing laboratory detection of disease. part 3: detecting a hantavirus disease event: a case study.	a purposive syndromic classification diagnostic system, with known means to ends, has been developed that extracts bits of structural information from endogenous laboratory data. an edifice of structural information for organization, regulation, and decision-making was built for determining future pathophysiological events by asking the fewest questions to define the next event uniquely. the structural information is based on laboratory ordering patterns of physicians for patient populations the ...	1997	10173024
the enigmatic haemorrhagic fevers.		1997	9496275
hantavirus pulmonary syndrome in the province of rio negro, argentina, 1993-1996.	early in 1995 the first case of hantavirus pulmonary syndrome was serologically confirmed in el bolsón (province of río negro, argentina), corresponding to the third outbreak reported in argentina. a total of 26 cases of hps related to the andean region of rio negro province, were reported from 1993 to 1996, 17 in el bolsón, 4 in san carlos de bariloche, and 5 in buenos aires. the incidence rate was 5.03 x 100,000 with a mortality rate of 51.85 x 100. the occurrence of cases was mainly seasonal, ...	1997	9640780
hantavirus pulmonary syndrome. report of the first three cases in são paulo, brazil.	the hantavirus pulmonary syndrome was first recognized in cases that occurred in the u.s. in 1993, which served as an alert not only for american physicians but also for physicians in other countries for the identification of the disease. in the city of são paulo, brazil, 3 cases of the syndrome were recorded in 1993. the patients were young brothers residing in the mata atlântica (atlantic forest) region submitted to recent deforestation. two of the patients died of acute respiratory insufficie ...	1997	9640788
hantavirus pulmonary syndrome in the rural area of juquitiba, são paulo metropolitan area, brazil.		1997	9640790
[the pulmonary syndrome produced by hantaviruses].		1997	9654969
[the history of the identification of pulmonary syndrome due to hantavirus in the argentina southern andes].		1997	9674235
atypical respiratory pathogens.	the main atypical pathogens in respiratory tract infections are classified on the basis of their ability to cause atypical pneumonia. this is not a well-defined clinical entity, and it is evident that atypical pathogens can sometimes cause 'typical' pneumonias and vice versa. this emphasizes the need for microbiological diagnosis, since it affects the selection of proper treatment, in which beta-lactam antibiotics and aminoglycosides are not effective. moreover, mixed infections caused by atypic ...	1997	11864199
[infections always present at the dawn of the 21st century].	despite the many scientific achievements realized in recent years, infectious diseases still remain the main cause of premature mortality worldwide. it is also growing increasingly difficult to fight infections. tuberculosis and malaria are making a comeback, cholera and yellow fever are making new inroads into countries where they¿ve never been before, other diseases are developing resistance to antibiotics and have in some cases become incurable, and new diseases such as ebola-induced hemorrh ...	1997	12322621
emerging pathogens: the hong kong experience.		1997	9594216
[studies on the experimental transmission of rattus-borne hantavirus by ornithonyssus bacoti].	to demonstrate the role of rat mite (ornithonyssus bacoti) in the transmission of rattus-borne hemorrhagic fever with renal syndrome (hfrs).	1998	12078291
anne boleyn, the sweating sickness, and the hantavirus: a review of an old disease with a modern interpretation.		1998	11619876
implications of the analogy between recombinant cytokine toxicities and manifestations of hantavirus infections.	the etiologic hantavirus of the 1993 emergence of an acute pulmonary failure syndrome in the area around northwestern new mexico was quickly recognized as related to the hantaan virus responsible for the outbreak of korean epidemic hemorrhagic fever (ehf) among un troops in 1951. discovery of the new disease which was named the hantavirus pulmonary syndrome (hps) and its causative agent the sine nombre virus (snv) inspired detailed comparisons between the two disorders. major damage to the epith ...	1998	10850356
[hantavirus emergence in the americas and in argentina].		1998	9674240
[pathogenesis, physiopathology, clinical manifestations and treatment of hantavirus pulmonary syndrome].		1998	9674241
[epidemiology of hantavirus pulmonary syndrome in argentina (1991-1997)].		1998	9674242
[epidemic outbreak of hantavirus pulmonary syndrome in argentina. molecular evidence of person to person transmission of andes virus].		1998	9674243
[reservoirs and genetic viral diversity].		1998	9674244
[hantavirus pulmonary syndrome. summary of the findings in argentina].		1998	9674245
[aids and the challenge of the emergent diseases. closing remarks].		1998	9674258
pathogenesis of a north american hantavirus, black creek canal virus, in experimentally infected sigmodon hispidus.	this report describes the first detailed analysis of the replication, persistence, and excretion of a north american hantavirus in its natural rodent reservoir. black creek canal virus was isolated from sigmodon hispidus (cotton rat) shortly after the identification of a hantavirus pulmonary syndrome (hps) case occurring in southern florida. six-week-old male cotton rats were inoculated subcutaneously with 1,000 tissue culture infectious doses. viral complementary rna (vcrna) was quantified as a ...	1998	9684629
automatic detection of conserved rna structure elements in complete rna virus genomes.	we propose a new method for detecting conserved rna secondary structures in a family of related rna sequences. our method is based on a combination of thermodynamic structure prediction and phylogenetic comparison. in contrast to purely phylogenetic methods, our algorithm can be used for small data sets of approximately 10 sequences, efficiently exploiting the information contained in the sequence variability. the procedure constructs a prediction only for those parts of sequences that are consi ...	1998	9685502
characterization of the nucleic acid binding properties of tomato spotted wilt virus nucleocapsid protein.	tomato spotted wilt tospovirus (tswv) is the type member of the plant-infecting viruses of the genus tospovirus in the family bunyaviridae. the three tswv rnas are encapsidated with nucleocapsid (n) protein to form ribonucleoprotein (rnp) which serves as the template for viral transcription and replication. regions of the open reading frame coding for the n protein on the small (s) rna were subcloned into pet protein expression vectors and expressed in escherichia coli bl21 (de3) cells. full-len ...	1998	9705250
antigenic characterization of hantaan and seoul virus nucleocapsid proteins expressed by recombinant baculovirus: application of a truncated protein, lacking an antigenic region common to the two viruses, as a serotyping antigen.	hantaan virus (htn) and seoul virus (seo) are members of the genus hantavirus in the family bunyaviridae and are causative agents of hemorrhagic fever with renal syndrome. the complete and truncated nucleocapsid proteins (np) of htn and seo were expressed by a recombinant baculovirus system. antigenic characterization of the np using monoclonal antibodies (mabs) indicated that the binding sites for the serotype-specific mabs were located between amino acids (aa) 155 and 429. a western blot assay ...	1998	9705385
from the centers for disease control and prevention. hantavirus pulmonary syndrome--colorado and new mexico, 1998.		1998	9707130
southwest cautious over hantavirus outbreak.		1998	9713524
host genes and infectious diseases.		1998	9716963
human dobrava hantavirus infections in estonia.	outbreaks of severe hemorrhagic fever with renal syndrome (hfrs) caused by dobrava hantavirus (dob) have been reported in albania, greece, and bosnia-herzegovina. a seroepidemiologic study conducted by the authors in estonia provided the first evidence of human dob infection in a baltic country. hantavirus infection was first confirmed in estonia in 1986 and believed related to puumala hantavirus (puu). to enable precise serotyping, serum samples were collected from 1728 healthy people in 11 ...	1998	9717928
[america hantaviruses: new data and implications].		1998	9718552
isolated abducens nerve palsy as a complication of haemorrhagic fever with renal syndrome.		1998	9719177
hantavirus pulmonary syndrome treated with inhaled nitric oxide.		1998	9726354
lack of serologic evidence for an association between hantavirus infection and end-stage renal disease.		1998	9730717
zoonoses and haemorrhagic fever.	virus zoonoses causing haemorrhagic fever have been recognized in three major families: arenaviridae, bunyaviridae and filoviridae. all are negative-stranded rna viruses, with genomes in two segments, three segments, or non-segmented, respectively. acquisition of haemorrhagic fever in man generally requires close contact with a vertebrate vector species, usually rodents, for the arenaviruses and bunyaviruses. in the case of filoviruses, the vector is currently unknown, but these viruses may infe ...	1998	9737374
hantaviruses: an emerging threat to human health?		1998	9742991
high prevalence of hantavirus infection in indian communities of the paraguayan and argentinean gran chaco.	serologic evidence of past infection with a sin nombre-like hantavirus(es) was demonstrated in 78 (40.4%) of 193 indians living in western paraguay and in 38 (17.1%) of 222 indians inhabiting the salta province of northern argentina. in both populations seroprevalence increased with age, with the most striking increase occurring at 18 years of age in the paraguayan population and at 35 years of age in the salta population. the peak prevalences in both populations (66.6% and 44.0%, respectively) ...	1998	9749641
ecology and demographics of hantavirus infections in rodent populations in the walker river basin of nevada and california.	to study the ecologic correlates of hantavirus in deer mice (peromyscus maniculatus), we sampled 114 sites in the walker river basin of nevada and california in 1995-1996. blood samples were tested for antibody to hantavirus, and a subset of samples was also tested for virus rna by reverse transcription-polymerase chain reaction. average prevalence of antibody-positive mice was 17%, with heavier males the most likely to be infected. antibody prevalence varied within repeatedly sampled sites from ...	1998	9749642
first reported case of hantavirus pulmonary syndrome in oklahoma.	hantavirus pulmonary syndrome (hps) is a condition of rapidly progressive pulmonary failure with a case-fatality rate of almost 50 percent. rodents serve as the reservoir for hantaviruses and human infection occurs primarily via aerosolized virus in rodent excreta. the rodent reservoir for the disease is widespread across oklahoma and the first case of hps has recently been confirmed in an oklahoma resident. physicians should suspect hps in a previously healthy person who develops a febrile illn ...	1998	9763765
hantavirus seropositivity in israeli patients with renal failure.	the hantavirus is known to cause hemorraghic fever with renal syndrome (hfrs), which is widely spread in europe and asia. several reports have shown an association of hantavirus antibody titers and the occurrence of renal dysfunction. from these observations, it appears that the virus is widely distributed, and different strains prevail in various areas. in the present work we studied 81 patients with end-stage renal-failure under hemodialysis (hd) treatment, 55 with mild to moderate renal failu ...	1998	9765032
[in the month of may, do whatever you please...].		1998	9775088
infectious agents and the etiology of chronic idiopathic diseases.	at the end of the nineteenth century, the field of microbiology was born, and the infectious nature of many previously unexplained diseases was illuminated as powerful new technology was applied. at the end of the twentieth century, the etiology of myriad chronic diseases remains unexplained. we have argued that many of these diseases have clinical, epidemiological, and pathological features that suggest a role for microbes in their pathogenesis. although definitive evidence of microbial disease ...	1998	9779355
nucleotide sequence and phylogenetic analysis of the medium (m) genomic rna segments of three hantaviruses isolated in china.	the medium (m) genome segment of hantaviruses (family bunyaviridae) encodes the two virion glycoproteins. g1 and g2, as a precursor protein in the complementary sense rna. we determined the nucleotide sequences of the m genome segments of three chinese hantavirus isolates, a hantaan-type (htn) virus designated a9 and two seoul-type (seo) viruses designated l99 and hb55, and compared them to those of other htn or seo viruses isolated in eastern asia. the m segment of a9 is 3616 nucleotides in len ...	1998	9784066
[anti-hantavirus antibodies in school children in salvador, bahia].	hantavirosis are emerging diseases in the americas. although considered rare in children, among the five cases diagnosed in brazil, one was in this age group. to know the serum-prevalence of hantavirosis in the pediatric group (schoolchildren) of low social economic level in salvador, bahia state, and to associate demographic, socio-economic and environmental factors to the serologic results, a standard questionnaire was applied and blood samples were collected from 379 students of two public sc ...	1998	9789441
a major outbreak of hemorrhagic fever with renal syndrome in the samara region, european russia.		1998	9795799
seroprevalence of antibodies to hantavirus in health care workers and other residents of southern argentina.		1998	9798052
hantavirus infection in the four corners region of usa in 1998.		1998	9802275
isolation and characterization of puumala hantavirus from norway: evidence for a distinct phylogenetic sublineage.	puumala (puu) hantavirus is the aetiological agent of nephropathia epidemica (ne), a mild form of haemorrhagic fever with renal syndrome, which occurs in fennoscandia, central europe and russia. in norway, ne-like disease has been reported since 1946 and about 50 cases are diagnosed annually; however, the causative agent has not been characterized. in this study, a virus originating from bank voles (clethrionomys glareolus) trapped near the town of eidsvoll (akershus county) was isolated and pas ...	1998	9820135
completion of the tula hantavirus genome sequence: properties of the l segment and heterogeneity found in the 3' termini of s and l genome rnas.	in this study the l segment and the 5' and 3' termini of the s, m and l segments of the prototype tula hantavirus (tul) were sequenced, thus completing the first determination of the genome sequence of a hantavirus that has not been linked to any human disease. the tul l segment comprises 6541 nt with one orf of 6459 nt in the antigenome sense. this orf potentially encodes a 2153 aa protein with a predicted molecular mass of 247 kda. the amino acid sequence includes all the motifs conserved in r ...	1998	9820136
a minority of seropositive wild bank voles (clethrionomys glareolus) show evidence of current puumala virus infection.	bank voles (clethrionomys glareolus) serve as the reservoir for puumala (puu) virus, the aetiologic agent of nephropathia epidemica. the animals are believed to be persistently infected and the occurrence of serum antibodies is usually taken as an evidence of active infection. we found serum antibodies to puu virus in 42 of 299 wild bank voles captured in a puu virus endemic area. puu virus rna was demonstrated in lung specimens of 11 of these 42 animals and in 2 of them antigen was also found. ...	1998	9825795
epidemiology of hantavirus infections in europe.		1998	9829467
hantavirus infection--new threats by an old virus.		1998	9829468
black creek canal virus infection in sigmodon hispidus in southern florida.	a total of 1,500 small mammals were collected and tested for antibodies cross-reactive to sin nombre virus (hantavirus: bunyaviridae) at 89 sites in a 1,600 km2 study area of southern florida. more than 95% of the 123 seropositive animals were cotton rats (sigmodon hispidus), suggesting infection by black creek canal virus, although seroreactive rattus rattus (5 of 294) and peromyscus gossypinus (1 of 39) also were captured. crude seroprevalence in s. hispidus was 11%. seroprevalence increased w ...	1998	9840584
short report: decrease in seroprevalence of antibodies to hantavirus in rodents from 1993-1994 hantavirus pulmonary syndrome case sites.	rodent trapping was conducted at seven hantavirus pulmonary syndrome (hps) case sites from june 1993 to march 1994 during the hps outbreak in the southwestern united states. to determine if there were changes in the rodent population or the hantavirus seroprevalence in rodents since the hps outbreak, rodents were trapped at the same sites three years later using the same trapping protocol. the trap success decreased from the numbers trapped during the outbreak, however, the number of peromyscus, ...	1998	9660455
retrospective serological and genetic study of the distribution of hantaviruses in greece.	a retrospective serological and genetic study of hantaviruses responsible for hemorrhagic fever with renal syndrome (hfrs) in greece during the last 17 years is presented. fifty-one serum samples taken from 30 hfrs cases previously diagnosed by immunofluorescence assay were tested by elisa for igg (hantaan, dobrava, and puumala) and igm antibodies (hantaan and puumala). results were compatible with the majority of infections being related to hantaviruses carried by rodents of the subfamily murin ...	1998	9661842
acute exacerbation of autoimmune liver disease associated with hantaviral infection.	hantavirus is known to cause haemorrhagic fever with renal syndrome (hfrs). although liver dysfunction has been reported in hfrs, hepatic manifestations of hantaviral infection have not been well described. we describe a case of autoimmune cholangitis in which an exacerbation of hepatitis was associated with hantaviral infection. seroconversion of both igg- and igm-class antibodies to hantavirus was noted coincident with acute exacerbation of hepatitis, which was resolved promptly by treatment w ...	1998	9670364
distinguishing hantavirus pulmonary syndrome from acute respiratory distress syndrome by chest radiography: are there different radiographic manifestations of increased alveolar permeability?	hantavirus infection may cause diffuse air space disease, termed hantavirus pulmonary syndrome (hps). the authors sought to determine if chest radiographs could differentiate hps from typical acute respiratory distress syndrome (ards). the authors identified patients with either hps (n = 11) or acute ards (n = 32) and selected the earliest chest radiograph showing diffuse airspace disease, and a chest radiograph taken 24 to 48 hours previously. thoracic and general radiologists first viewed the ...	1998	9671418
stable expression of nucleocapsid proteins of puumala and hantaan virus in mammalian cells.	the development of an in vitro-system for the stable expression and the analysis of native hantavirus proteins using hantaviral cdna is of particular interest. as a first step the expression of the hantavirus nucleocapsid (n) proteins in mammalian cells was studied in more detail. the cdna of the s-rna segment of puumala virus strain cg-1820 and hantaan virus strain 76-118 was used for the construction of eucaryotic expression vectors that allow the generation and selection of mammalian cells ha ...	1998	9857992
ecologic studies of rodent reservoirs: their relevance for human health.	within the past few years, the number of "new" human diseases associated with small-mammal reservoirs has increased dramatically, stimulating renewed interest in reservoir ecology research. a consistent, integrative approach to such research allows direct comparisons between studies, contributes to the efficient use of resources and data, and increases investigator safety. we outline steps directed toward understanding vertebrate host ecology as it relates to human disease and illustrate the rel ...	1998	9866729
an outbreak of hantavirus pulmonary syndrome, chile, 1997.	an outbreak of 25 cases of andes virus-associated hantavirus pulmonary syndrome (hps) was recognized in southern chile from july 1997 through january 1998. in addition to the hps patients, three persons with mild hantaviral disease and one person with asymptomatic acute infection were identified. epidemiologic studies suggested person-to-person transmission in two of three family clusters. ecologic studies showed very high densities of several species of sigmodontine rodents in the area.	1998	9866751
evaluation of puumala virus igg and igm enzyme immunoassays based on recombinant baculovirus-expressed nucleocapsid protein for early nephropathia epidemica diagnosis.	puumala virus (puu), a member of hantavirus genus, is the causative agent of nephropathia epidemica (ne), a milder form of hemorrhagic fever with renal syndrome (hfrs). rapid diagnosis is essential for clinical management of ne.	1998	9646005
genetic diversity and epidemiology of hantaviruses in argentina.	phylogenetic analysis of a 292-nucleotide (nt) fragment of the hantavirus m genome segment from 36 rodent and 13 human samples from three known foci of hantavirus infection in argentina was conducted. a 1654-nt fragment of the m genome segment was analyzed for 1 representative of 7 genetically distinct hantavirus lineages identified. additionally, the nt sequence of the complete m genome segments of lechiguanas, oran, and hu39694 hantavirus genotypes was determined. nt sequence comparisons revea ...	1998	9498428
first case of infection with hantavirus dobrava in germany.		1998	10052557
high-producer allele of tumour necrosis factor-alpha is part of the susceptibility mhc haplotype in severe puumala virus-induced nephropathia epidemica.	the biallelic polymorphisms in the tumour necrosis factor-alpha (tnf-alpha) gene promoter region were studied in patients with nephropathia epidemica (ne). the rarer tnf2 allele, associated with a high tnf-alpha producer phenotype, was more frequently found in hospitalized ne patients (42%) than in healthy controls (15%; p=0.0064). the putative role of tnf2 as an independent risk factor for ne is discussed.	1998	10066063