Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| [construction of a recombinant adenovirus carrying the hantaan virus glycoprotein g2 gene and its expression in hela cells]. | we constructed the recombinant adenovirus expressing the glycoprotein g2 of hantaan virus. firstly we obtained coding gene fragment of g2 by pcr, and subsequently inserted the gene of interest into the adenoviral pshuttle vector pad5-cmv. then we co-transfected the recombinant pshuttle vector and adenovirus skeleton plasmid into hek293 cells by calcium phosphate precipitation method. after the recombinant adenovirus were packaged and amplified in hek293 cells, we observed the expression of repor ... | 2009 | 20112705 |
| sin nombre virus infection in field workers, colorado, usa. | we report 2 cases of sin nombre virus (snv) infection in field workers, possibly contracted through rodent bites. screening for antibodies to snv in rodents trapped in 2 seasons showed that 9.77% were seropositive. quantitative real-time pcr showed that 2 of 79 deer mice had detectable titers of snv rna. | 2010 | 20113567 |
| different cross-reactivity of human and rodent sera to tula virus and puumala virus. | tula virus (tulv) and puumala virus (puuv) are hantaviruses carried by the bank vole (myodes glareolus) and european common vole (microtus arvalis), respectively. puuv is a causative agent of hemorrhagic fever with renal syndrome (hfrs), while tulv is thought to be apathogenic to humans. the n-terminal regions of the n proteins from tulv and puuv were expressed and applied as enzyme-linked immunosorbent assay (elisa) antigens. colonized japanese grass voles (microtus montebelli) and balb/c mice ... | 2010 | 20116854 |
| the occurrence of hemorrhagic fever with renal syndrome in southern parts of bosnia and herzegovina. | bosnia and herzegovina (b&h) has been known as an endemic region for hemorrhagic fever with renal syndrome (hfrs) for over 50 years. multiple epidemics of this disease have been registered so far, especially in endemic parts of central and northeastern bosnia, as well as the sarajevo region. seroepidemiological investigations demonstrate naturalization of hantaviruses and their wide spread in b&h. however, there are no studies from the southern areas of b&h, and endemic foci of this disease are ... | 2009 | 20120399 |
| [hantavirosis: clinical and epidemiological characteristics of pediatric patients in chile]. | the first cases of hantavirus cardiopulmonary syndrome in children were described in the united states and represented 8% of the total reported cases; in chile, the proportion of pediatric cases represents 15% of all national cases. | 2010 | 20140316 |
| hantavirus nucleocapsid protein has distinct m7g cap- and rna-binding sites. | hantaviruses, members of the bunyaviridae family, are emerging category a pathogens that carry three negative stranded rna molecules as their genome. hantavirus nucleocapsid protein (n) is encoded by the smallest s segment genomic rna (viral rna). n specifically binds mrna caps and requires four nucleotides adjacent to the cap for high affinity binding. we show that the n peptide has distinct cap- and rna-binding sites that independently interact with mrna cap and viral genomic rna, respectively ... | 2010 | 20164193 |
| seoul virus suppresses nf-kappab-mediated inflammatory responses of antigen presenting cells from norway rats. | hantavirus infection reduces antiviral defenses, increases regulatory responses, and causes persistent infection in rodent hosts. to address whether hantaviruses alter the maturation and functional activity of antigen presenting cells (apcs), rat bone marrow-derived dendritic cells (bmdcs) and macrophages (bmdms) were generated and infected with seoul virus (seov) or stimulated with tlr ligands. seov infected both dcs and macrophages, but copies of viral rna, viral antigen, and infectious virus ... | 2010 | 20170933 |
| hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome, also known as hantavirus cardiopulmonary syndrome, is a recently described infectious syndrome found throughout the americas. although infection is sporadic and uncommon compared with other atypical pneumonia syndromes, its high mortality rate warrants the maintenance of a high index of suspicion in rural settings. because no specific therapies are available for the disease, prevention and early recognition play an important role in reducing mortality from the dise ... | 2010 | 20171551 |
| highly differentiated, resting gn-specific memory cd8+ t cells persist years after infection by andes hantavirus. | in man, infection with south american andes virus (andv) causes hantavirus cardiopulmonary syndrome (hcps). hcps due to andv is endemic in southern chile and much of argentina and increasing numbers of cases are reported all over south america. a case-fatality rate of about 36% together with the absence of successful antiviral therapies urge the development of a vaccine. although t-cell responses were shown to be critically involved in immunity to hantaviruses in mouse models, no data are availa ... | 2010 | 20174562 |
| pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. | hantavirus infections are noted for their ability to infect endothelial cells, cause acute thrombocytopenia, and trigger 2 vascular-permeability-based diseases. however, hantavirus infections are not lytic, and the mechanisms by which hantaviruses cause capillary permeability and thrombocytopenia are only partially understood. the role of beta(3) integrins in hemostasis and the inactivation of beta(3) integrin receptors by pathogenic hantaviruses suggest the involvement of hantaviruses in altere ... | 2010 | 20181715 |
| generation of e3-deleted canine adenovirus type 2 expressing the gc glycoprotein of seoul virus by gene insertion or deletion of related terminal region sequences. | seoul virus (seov) is one of the four hantaviruses known to cause haemorrhagic fever with renal syndrome. the medium genome segment encodes the gn/gc glycoproteins of seov, which form the major structural part of the virus envelope. gc and/or gn are the candidate antigens of hantavirus for induction of a highly immunogenic response for hantavirus vaccine. in this study, the immune response induced by a replication-competent recombinant canine adenovirus type 2 expressing the gc protein of seov w ... | 2010 | 20181748 |
| crossing borders in health communication research: toward an ecological understanding of context, complexity, and consequences in community-based health education in the u.s.-mexico borderlands. | in the past 15 years, researchers in health information dissemination have made significant strides in addressing context, complexity, and consequences (sharf's "3 cs") in theory, research, and praxis. the goal of integrating the 3 cs in this field, however, remains a challenge. in this article, the authors present 6 principles of a postmodern ecological approach to health information dissemination that attempts such integration. the authors outline proposed principles and use a multiyear, inter ... | 2009 | 20183369 |
| serological evidence of human hantavirus infections in guinea, west africa. | we recently discovered a novel hantavirus, sangassou virus, in guinea, west africa. using enzyme-linked immunosorbent assays followed by confirmatory and serotyping assays, we retrospectively detected hantavirus antibodies in 3 (4.4%) of 68 patients with fever of unknown origin in sangassou village, forest guinea. a population-based survey in forest guinea (n = 649) found the prevalence of hantavirus antibodies to be 1.2%. specific neutralizing antibodies against sangassou virus were demonstrate ... | 2010 | 20187741 |
| [comparison on the difference of virulence between hantaan virus and seoul virus isolated both from rattus norvegicus]. | comparing the difference of virulence between the strain cgrn5310 (htnv) and the strain hr54 (seov) isolated both from rattus norvegicus. | 2009 | 20193387 |
| [complete sequence of the m segment of amur virus in rodent from china]. | to study the complete sequence of m segment of amur virus in rodents and to explore their molecular characteristics. | 2009 | 20193388 |
| [association of hemorrhagic fever with renal syndrome and hla-drb allele polymorphisms in han nationality, hubei province.]. | to understand the association of human leukocyte antigen (hla)-drb polymorphism and patients diagnosed as hemorrhagic fever with renal syndrome (hfrs). | 2009 | 20193583 |
| [rare case of crimean haemorrhagic fever in a pregnant woman]. | a rare case of crimean haemorrhagic fever in a pregnant woman during the sixth month of gestation is described. the typical clinical course of the disease is present with positive anamnesis and visible locus from tick bite. after several days, fever and local lymphadenitis appear, followed by severe toxicoinfectious and haemorrhagic syndromes. the disease is proved virologically and serologically. the outcome is favourable for the pregnant woman. she is discharged home after 16-day hospital trea ... | 2009 | 20198776 |
| electron cryotomography of tula hantavirus suggests a unique assembly paradigm for enveloped viruses. | hantaviruses (family bunyaviridae) are rodent-borne emerging viruses that cause a serious, worldwide threat to human health. hantavirus diseases include hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. virions are enveloped and contain a tripartite single-stranded negative-sense rna genome. two types of glycoproteins, g(n) and g(c), are embedded in the viral membrane and form protrusions, or "spikes." the membrane encloses a ribonucleoprotein core, which consists of ... | 2010 | 20219926 |
| characterization and outcome following puumala virus infection: a retrospective analysis of 75 cases. | infection with the puumala virus (puuv), which belongs to the hantavirus family, is a common but often neglected cause of acute kidney injury (aki) in endemic areas of europe. the objective of the present study was to systematically analyse clinical presentation and renal outcomes following puuv infection. | 2010 | 20223893 |
| simultaneous detection of cdc category "a" dna and rna bioterrorism agents by use of multiplex pcr & rt-pcr enzyme hybridization assays. | assays to simultaneously detect multiple potential agents of bioterrorism are limited. two multiplex pcr and rt-pcr enzyme hybridization assays (mpcr-eha, mrt-pcr-eha) were developed to simultaneously detect many of the cdc category "a" bioterrorism agents. the "bio t" dna assay was developed to detect: variola major (vm), bacillus anthracis (ba), yersinia pestis (yp), francisella tularensis (ft) and varicella zoster virus (vzv). the "bio t" rna assay (mrt-pcr-eha) was developed to detect: ebola ... | 2009 | 20224751 |
| modulation of apoptosis and immune signaling pathways by the hantaan virus nucleocapsid protein. | herein, we show a direct relationship between the hantaan virus (htnv) nucleocapsid (n) protein and the modulation of apoptosis. we observed an increase in caspase-7 and -8, but not -9 in cells expressing htnv n protein mutants lacking amino acids 270-330. similar results were observed for the new world hantavirus, andes virus. nuclear factor kappa b (nf-kappab) was sequestered in the cytoplasm after tumor necrosis factor receptor (tnfr) stimulation in cells expressing htnv n protein. further, t ... | 2010 | 20227103 |
| beechnuts and outbreaks of nephropathia epidemica (ne): of mast, mice and men. | 2010 | 20237057 | |
| truncated hantavirus nucleocapsid proteins for serotyping sin nombre, andes, and laguna negra hantavirus infections in humans and rodents. | sin nombre virus (snv), andes virus (andv), and laguna negra virus (lanv) have been known as the dominant causative agents of hantavirus pulmonary syndrome (hps). andv and lanv, with different patterns of pathogenicity, exist in a sympatric relationship. moreover, there is documented evidence of person-to-person transmission of andv. therefore, it is important in clinical medicine and epidemiology to know the serotype of a hantavirus causing infection. truncated snv, andv, and lanv recombinant n ... | 2010 | 20335425 |
| hantavirus pulmonary syndrome, french guiana. | 2010 | 20350412 | |
| high-resolution computed tomography findings in hantavirus pulmonary syndrome. | the hantavirus pulmonary syndrome (hps) is an acute, rapidly progressive disease transmitted by rodent excreta, with endothelial damage playing a central role in the pathophysiology. it usually affects rural workers. the lung itself is the target organ and reflects all the patterns of endothelial involvement of this disease. the radiologic findings of hps are vast and range from a mild interstitial involvement to total obliteration of the airspaces with or without pleural effusion. there are no ... | 2010 | 20351581 |
| recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: toward the development of high-throughput screening flow cytometry assays. | hantaviruses cause two severe diseases in humans: hemorrhagic fever with renal syndrome (hfrs) and hantavirus cardiopulmonary syndrome (hcps). the lack of vaccines or specific drugs to prevent or treat hfrs and hcps and the requirement for conducting experiments in a biosafety level 3 laboratory (bsl-3) limit the ability to probe the mechanism of infection and disease pathogenesis. in this study, we developed a generalizable spectroscopic assay to quantify saturable fluorophore sites solubilized ... | 2010 | 20363206 |
| association of -308g/a polymorphism in the tumor necrosis factor-alpha gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the ribeirão preto region, brazil. | activation of the immune response in hantavirus cardiopulmonary syndrome (hcps) leads to a high tnf production, probably contributing to the disease. the polymorphic tnf2 allele (tnf -308g/a) has been associated with increased cytokine production. we investigated the association of the tnf2 allele with the outcome of hantavirus infection in brazilian patients. a total of 122 hantavirus-exposed individuals (26 presenting hcps and 96 only hantavirus seroconversion) were studied. the tnf2 allele wa ... | 2010 | 20372945 |
| a global perspective on hantavirus ecology, epidemiology, and disease. | hantaviruses are enzootic viruses that maintain persistent infections in their rodent hosts without apparent disease symptoms. the spillover of these viruses to humans can lead to one of two serious illnesses, hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. in recent years, there has been an improved understanding of the epidemiology, pathogenesis, and natural history of these viruses following an increase in the number of outbreaks in the americas. in this review, curre ... | 2010 | 20375360 |
| hantavirus outbreak associated with laboratory rats in yunnan, china. | an outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (college a) in kunming, yunnan province, china in 2003. subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at college a and two other institutions. hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. epidemiologic data indicated that the human infections were a result of zoonotic transmissi ... | 2010 | 20380897 |
| roles of human disturbance, precipitation, and a pathogen on the survival and reproductive probabilities of deer mice. | climate change, human disturbance, and disease can have large impacts on the dynamics of a species by affecting the likelihood of survival and reproduction of individuals. we investigated the roles of precipitation, off-road vehicle (orv) alteration of habitat, and infection with sin nombre virus on the survival and reproductive probabilities of deer mice (peromyscus maniculatus). we used generalized linear mixed models to estimate the effects of these factors and their interactions by fitting c ... | 2010 | 20392022 |
| hormonal deficiencies during and after puumala hantavirus infection. | previous reports have described panhypopituitarism associated with severe cases of hemorrhagic fever with renal syndrome (hfrs), but the prevalence of hormonal deficiencies after nephropathia epidemica (ne), a milder form of hfrs, has not been studied. this study was conducted in order to determine the prevalence of hormonal defects in patients with acute ne and during long-term follow-up. fifty-four patients with serologically confirmed acute ne were examined by serum hormonal measurements duri ... | 2010 | 20397036 |
| serologic survey of hantavirus infection, brazilian amazon. | 2010 | 20409399 | |
| hantaviruses in small mammals and humans in the coastal region of zhejiang province, china. | to gain more insights into the epidemiology of hantaviruses in the coastal region of zhejiang province, china, the morbidity and mortality of hemorrhagic fever with renal syndrome (hfrs) were analyzed in two coastal areas: cixi (hilly terrain) and wenzhou (mountainous terrain). more hfrs cases have been reported in cixi than in wenzhou. annual incidence rate of hfrs in cixi had been on the level of approximately 1.5/100,000 from 1968 (when the first hfrs case was reported) to 2007, with the high ... | 2010 | 20419812 |
| tula virus in populations of small terrestrial mammals in a rural landscape. | over 5 years (2000-2004), populations of small mammals from a rural landscape in southern moravia (czech republic) were investigated for the presence of tula virus (tulv) antigen using the elisa set hantagnost. in total, 1566 individuals from 10 species were examined. the prevalence in the common vole (microtus arvalis pallas 1778), the main reservoir of tulv, was 10% (n = 871). the prevalence of tulv antigen increases with its population numbers. the highest number of tulv antigen-positive comm ... | 2010 | 20420534 |
| [construction and identification of a new type of recombinant adenovirus containing s0.7 gene of hantavirus]. | to construct a adenovirus vector containing the 0.7 kb fragment of s gene of hantavirus, cag promoter, and wpre (mrna-stabilizing post-transcriptional regulatory element from the woodchuck hepatitis virus). | 2010 | 20423645 |
| novel hantavirus in the flat-skulled shrew (sorex roboratus). | genetically distinct hantaviruses have been identified recently in multiple species of shrews (order soricomorpha, family soricidae) in eurasia and north america. to corroborate decades-old reports of hantaviral antigens in shrews from russia, archival liver and lung tissues from 4 siberian large-toothed shrews (sorex daphaenodon), 5 eurasian least shrews (sorex minutissimus), 12 flat-skulled shrews (sorex roboratus), and 18 tundra shrews (sorex tundrensis), captured in the sakha republic in nor ... | 2010 | 20426682 |
| seewis virus: phylogeography of a shrew-borne hantavirus in siberia, russia. | hantaviral antigens were originally reported more than 20 years ago in tissues of the eurasian common shrew (sorex araneus), captured in european and siberian russia. the recent discovery of seewis virus (swsv) in this soricid species in switzerland provided an opportunity to investigate its genetic diversity and geographic distribution in russia. | 2010 | 20426688 |
| hantavirus-like particles generated in cho cells induce specific immune responses in c57bl/6 mice. | a safe and effective hantavirus vaccine is highly desirable since hantaviruses are distributed worldwide and cause an acute and often fatal disease (hemorrhagic fever with renal syndrome, hfrs). virus-like particles (vlps) displaying functional viral proteins could provide effective vaccines against a few viruses, but their ability to induce hantavirus-specific immune response has not been adequately investigated. to measure the immunogenicity of hantaan virus-like particles (htn-vlps) vaccine, ... | 2010 | 20433802 |
| comprehensive panel of real-time taqman polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and new world hantaviruses. | viral hemorrhagic fever is caused by a diverse group of single-stranded, negative-sense or positive-sense rna viruses belonging to the families filoviridae (ebola and marburg), arenaviridae (lassa, junin, machupo, sabia, and guanarito), and bunyaviridae (hantavirus). disease characteristics in these families mark each with the potential to be used as a biological threat agent. because other diseases have similar clinical symptoms, specific laboratory diagnostic tests are necessary to provide the ... | 2010 | 20439981 |
| cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. | here we characterize the interaction between the glycoproteins (gn and gc) and the ribonucleoprotein (rnp) of puumala virus (puuv; genus hantavirus, family bunyaviridae). the interaction was initially established with native proteins by co-immunoprecipitating puuv nucleocapsid (n) protein with the glycoprotein complex. mapping of the interaction sites revealed that the n protein has multiple binding sites in the cytoplasmic tail (ct) of gn and is also able to bind to the predicted ct of gc. the ... | 2010 | 20444994 |
| hantavirus outbreak in western europe: reservoir host infection dynamics related to human disease patterns. | within europe, puumala virus (puuv) is the causal agent of nephropathia epidemica (ne) in humans, a zoonotic disease with increasing significance in recent years. in a region of belgium with a historically high incidence of ne, bank voles (the puuv reservoir hosts), were monitored for puuv igg antibody prevalence in nine study sites before, during, and after the highest ne outbreak recorded in belgium in 2005. we found that the highest numbers of puuv igg-positive voles coincided with the peak o ... | 2011 | 20450527 |
| [dynamics of hantavirus detection in the excretory organs of apodemus mice and its relation to epidemic manifestations of hantavirus infection]. | this paper presents data on the detection of hantavirus in the excretory organs of apodemus mice which are natural carriers of pathogenic hantaviral serotypes in the primorye region. acute infection periods were detected in naturally infected rodents with the highest hantavirus dissemination to the environment in different phases of rodent population cycles. there was a relationship between the rise of morbidity and the seasonal manifestation of hemorrhagic fever with renal syndrome morbidity an ... | 2010 | 20455471 |
| pathology of black creek canal virus infection in juvenile hispid cotton rats (sigmodon hispidus). | the purpose of this study was to assess the effect of inoculum dose on the pathogenesis of black creek canal virus (bccv) infection in the hispid cotton rat (sigmodon hispidus), the principal host of bccv. no sign of illness was observed in any of the 52 juvenile hispid cotton rats inoculated with 3.1, 1.1, -0.9, or -2.9 log(10) median infectious doses(veroe6) (id(50-veroe6)) of bccv and euthanized on day 9, 18, 27, or 54 postinoculation (pi). analysis of virus assay and serological data indicat ... | 2010 | 20455779 |
| models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission. | hantavirus, a zoonotic disease carried by wild rodents, is spread among rodents via direct contact and indirectly via infected rodent excreta in the soil. spillover to humans is primarily via the indirect route through inhalation of aerosolized viral particles. rodent-hantavirus models that include direct and indirect transmission and periodically varying demographic and epidemiological parameters are studied in this investigation. two models are analyzed, a nonautonomous system of differential ... | 2010 | 20462286 |
| pathogenic hantaviruses andes virus and hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. | hantaviruses infect endothelial cells and cause 2 vascular permeability-based diseases. pathogenic hantaviruses enhance the permeability of endothelial cells in response to vascular endothelial growth factor (vegf). however, the mechanism by which hantaviruses hyperpermeabilize endothelial cells has not been defined. the paracellular permeability of endothelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (ve-cadherin) within adherens junctions, which ... | 2010 | 20463083 |
| a case report of crescentic glomerulonephritis associated with hantaan virus infection. | although various glomerular diseases in hantavirus infection have been reported, an association between hantavirus infection and crescentic glomerulonephritis has not been described. herein, we report a case of immune complex-mediated crescentic glomerulonephritis in a 70-year-old man with hantaan virus infection. | 2010 | 20466689 |
| comparison of the effects of puumala and dobrava viruses on early and long-term renal outcomes in patients with haemorrhagic fever with renal syndrome. | the clinical course and outcome of patients with haemorrhagic fever with renal syndrome (hfrs) caused by puumala (puuv) and dobrava viruses (dobv) were analyzed and whether it left long-term consequences on kidney function after 10 years was evaluated. | 2010 | 20470304 |
| the severity of puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than c-reactive protein determinations. | nephropathia epidemica (ne) is a scandinavian type of hemorrhagic fever with renal syndrome caused by puumala hantavirus. the clinical course of the disease varies greatly in severity. the aim of the present study was to evaluate whether plasma c-reactive protein (crp) and interleukin (il)-6 levels associate with the severity of ne. | 2010 | 20500875 |
| the severity of acute puumala hantavirus infection does not predict the long-term outcome of patients. | we have found greater urinary protein excretion and higher glomerular filtration rate (gfr) and blood pressure in patients 6 years after acute nephropathia epidemica (ne) compared with seronegative controls. the present aim was to establish whether the long-term outcome is determined by the severity of acute illness. | 2010 | 20502044 |
| steep rise in notified hantavirus infections in germany, april 2010. | from january to april 2010, 396 hantavirus infections were notified in germany, a considerable increase compared with previous years (mean: 83 for january-april 2004-2009) including the record-setting year, 2007 (n=232 january-april). most patients are residents of known puumala virus endemic areas in southern germany. the recent increase in notified hantavirus infections is probably due to an increased population density of the main animal reservoir, the bank vole (myodes glareolus). | 2010 | 20504391 |
| generation and characterization of genetic reassortants between puumala and prospect hill hantavirus in vitro. | hantaviruses belong to the family bunyaviridae characterized by tri-segmented rna genomes. depending on the hantavirus species, infection can lead to hantavirus cardiopulmonary or haemorrhagic fever with renal syndrome. in vitro studies suggest that pathogenic hantaviruses evade induction of innate antiviral responses, and this ability might determine the virulence in humans. since reverse genetic systems are not available, in vitro reassortment is currently the only way to culture defined hanta ... | 2010 | 20505009 |
| relationship of human behavior within outbuildings to potential exposure to sin nombre virus in western montana. | sin nombre virus (snv) causes hantavirus cardiopulmonary syndrome (hcps) in humans. transmission of snv among the deer mouse (peromyscus maniculatus) host predominates during spring and summer, and is greater in peridomestic than sylvan settings where, protected from uv light, snv may survive longer. incidence of hcps reflects these times and settings and is associated with inhalation of mouse excreta. little is known, however, about how human use of outbuildings contributes to potential exposur ... | 2010 | 20508970 |
| hantaviruses. | hantaviruses affect people worldwide, yet they remain poorly understood. this article explores the known history of hantaviruses. it describes diagnostic methods and potential options for treatment and prevention. | 2010 | 20513542 |
| sin nombre virus-specific immunoglobulin m and g kinetics in hantavirus pulmonary syndrome and the role played by serologic responses in predicting disease outcome. | sin nombre virus (snv) is the primary cause of hantavirus pulmonary syndrome (hps) in the united states. although other studies have demonstrated a possible association between neutralizing antibody titers and the severity of hps, the exact nature of serologic responses and their association with outcomes have not been fully characterized. | 2010 | 20521946 |
| convalescent pulmonary dysfunction following hantavirus pulmonary syndrome in panama and the united states. | the objective of this study was to document persistent pulmonary symptoms and pulmonary function abnormalities in adults surviving hantavirus pulmonary syndrome (hps). acute infection by most hantaviruses result in mortality rates of 25-35%, while in panama the mortality rate of 10% is contrasted by an unusually high incidence. in all types of hps, the viral prodrome, cardiopulmonary phase due to massive pulmonary capillary leak syndrome, and spontaneous diuresis are followed by a convalescent p ... | 2010 | 20524006 |
| ecology of hantavirus in a changing world. | hantavirus is a genus of virus represented by 45 different species and is hosted by small mammals, predominantly rats and mice. roughly, half of all hantaviruses cause diseases in humans that vary in morbidity from mild to severe. the natural and anthropogenic changes occurring in the environment appear to be impacting the ecology of hantaviruses and their natural hosts as well as the incidence of hantaviral diseases in humans. although such studies are limited at this time, there is evidence th ... | 2010 | 20536819 |
| central nervous system-related symptoms and findings are common in acute puumala hantavirus infection. | puumala hantavirus (puuv) causes a hemorrhagic fever with renal syndrome (hfrs) also called nephropathia epidemica (ne). recent case reports and retrospective studies suggest that ne may damage the pituitary gland. based on these observations, our goal was to explore the nature of this complication prospectively. | 2010 | 20545485 |
| [hantavirus infection associated to a staphylococcal sepsis. report of one case]. | we report a previously healthy 36-year-old mole who developed a pulmonary syndrome caused by hantavirus infection. he was admitted to an intensive care unit in shock and respiratory failure and died four hours after admission. blood cultures were positive for staphylococcus aureus. this patient could be an index case that shows, for the first time, an association of hantavirus pulmonary syndrome with staphylococcus aureus infection similar to what happens with other viruses. | 2010 | 20556338 |
| interaction between hantaviral nucleocapsid protein and the cytoplasmic tail of surface glycoprotein gn. | hantaviral n and gn proteins were shown to interact, thus providing the long-awaited evidence for one of the crucial steps in the virus replication at which rnps are directed to the site of the virus assembly. using pull-down assay and point mutagenesis it was demonstrated that intact, properly folded zinc fingers in the gn protein cytoplasmic tail as well as the middle domain of the n protein (that includes aa residues 80-248) are essential for the interaction. | 2010 | 20566401 |
| new world hantaviruses activate ifnlambda production in type i ifn-deficient vero e6 cells. | hantaviruses indigenous to the new world are the etiologic agents of hantavirus cardiopulmonary syndrome (hcps). these viruses induce a strong interferon-stimulated gene (isg) response in human endothelial cells. african green monkey-derived vero e6 cells are used to propagate hantaviruses as well as many other viruses. the utility of the vero e6 cell line for virus production is thought to owe to their lack of genes encoding type i interferons (ifn), rendering them unable to mount an efficient ... | 2010 | 20567522 |
| the triplet repeats of the sin nombre hantavirus 5' untranslated region are sufficient in cis for nucleocapsid-mediated translation initiation. | hantavirus nucleocapsid protein (n) can replace the cellular cap-binding complex, eukaryotic initiation factor 4f (eif4f), to mediate translation initiation. although n can augment translation initiation of nonviral mrna, initiation of viral mrna by n is superior. all members of the bunyaviridae family, including the species of the hantavirus genus, express either three or four primary mrnas from their tripartite negative-sense genomes. the 5' ends of the mrnas contain nonviral heterologous olig ... | 2010 | 20573811 |
| enhanced thrombin formation and fibrinolysis during acute puumala hantavirus infection. | nephropathia epidemica (ne) is a viral hemorrhagic fever with renal syndrome associated with thrombocytopenia and mild bleeding. we assessed activation of coagulation and fibrinolysis during the acute phase of ne. | 2010 | 20579693 |
| hantavirus infections in fluctuating host populations: the role of maternal antibodies. | infected females may transfer maternal antibodies (matabs) to their offspring, which may then be transiently protected against infections the mother has encountered. however, the role of maternal protection in infectious disease dynamics in wildlife has largely been neglected. here, we investigate the effects of puumala hantavirus (puuv)-specific matabs on puuv dynamics, using 7 years' data from a cyclic bank vole population in finland. for the first time to our knowledge, we partition seroposit ... | 2010 | 20591866 |
| genetic analysis of a hantavirus strain carried by niviventer confucianus in yunnan province, china. | hantavirus genome sequences were recovered from lung tissues of chinese white-bellied rats (niviventer confucianus) captured in yunnan province, china. pairwise comparison of the nucleotide and deduced amino acid sequences of the entire s and partial m and l segments indicated that the newly discovered virus strain, which was designated as strain yn509, was very different from other rodent-borne hantaviruses. phylogenetic analysis showed that the new strain fit into a clade containing da bie sha ... | 2010 | 20600393 |
| development of a lentiviral vector system to study the role of the andes virus glycoproteins. | to infect target cells, enveloped viruses use their virion surface proteins to direct cell attachment and subsequent entry via virus-cell membrane fusion. how hantaviruses enter cells has been largely unexplored. to study early steps of andes virus (andv) cell infection, a lentiviral vector system was developed based on a simian immunodeficiency virus (siv) vector pseudotyped with the andv-gn/gc envelope glycoproteins. the incorporation of gn and gc onto siv-derived vector particles was assessed ... | 2010 | 20619306 |
| an experimental test of factors attracting deer mice into buildings. | deer mice (peromyscus maniculatus) are the principal reservoir host of sin nombre virus (snv). deer mice use a wide variety of habitats including peridomestic settings in and around human dwellings, their presence in and around homes has been implicated as a risk factor for acquiring hantavirus pulmonary syndrome. deer mice are believed to enter buildings in order to gain access to a variety of resources including food, bedding material, and better thermal microclimates. however, no one has expe ... | 2009 | 20628475 |
| early diagnosis of hantavirus infection by family doctors can reduce inappropriate antibiotic use and hospitalization. | hantavirus infections are emerging infections that cause either hantavirus pulmonary syndrome or haemorrhagic fever with renal syndrome (hfrs). a recent swedish outbreak of nephropathia epidemica, a european hfrs, was analysed to study the patient flow and clinical picture and to investigate the value of an early diagnosis in general practice. design. in a retrospective design, medical records of verified cases of hantavirus infection were studied. | 2010 | 20642397 |
| satellite derived forest phenology and its relation with nephropathia epidemica in belgium. | the connection between nephropathia epidemica (ne) and vegetation dynamics has been emphasized in recent studies. changing climate has been suggested as a triggering factor of recently observed epidemiologic peaks in reported ne cases. we have investigated whether there is a connection between the ne occurrence pattern in belgium and specific trends in remotely sensed phenology parameters of broad-leaved forests. the analysis of time series of the modis enhanced vegetation index revealed that ch ... | 2010 | 20644685 |
| temporal and spatial host abundance and prevalence of andes hantavirus in southern argentina. | andes virus (and) is a hantavirus hosted by the sigmodontine rodent oligoryzomys longicaudatus in southern argentina, where it is responsible for most cases of hantavirus pulmonary syndrome (hps). our study provides data about the spatial variation in abundance of the rodent host of and hantavirus. we report results of a longitudinal study performed in a locality of the andean region of chubut province. from november 2003 (spring) to july 2006 (winter), o. longicaudatus was the most common speci ... | 2010 | 20645121 |
| confirmation of choclo virus as the cause of hantavirus cardiopulmonary syndrome and high serum antibody prevalence in panama. | choclo virus (chov) was described in sigmodontine rodents, oligoryzomys fulvescens, and humans during an outbreak of hantavirus cardiopulmonary syndrome (hcps) in 1999-2000 in western panama. although hcps is rare, hantavirus-specific serum antibody prevalence among the general population is high suggesting that chov may cause many mild or asymptomatic infections. the goals of this study were to confirm the role of chov in hcps and in the frequently detected serum antibody and to establish the p ... | 2010 | 20648614 |
| the 3' untranslated region of the andes hantavirus small mrna functionally replaces the poly(a) tail and stimulates cap-dependent translation initiation from the viral mrna. | in the process of translation of eukaryotic mrnas, the 5' cap and the 3' poly(a) tail interact synergistically to stimulate protein synthesis. unlike its cellular counterparts, the small mrna (smrna) of andes hantavirus (andv), a member of the bunyaviridae, lacks a 3' poly(a) tail. here we report that the 3' untranslated region (3'utr) of the andv smrna functionally replaces a poly(a) tail and synergistically stimulates cap-dependent translation initiation from the viral mrna. stimulation of tra ... | 2010 | 20660206 |
| switch to high-level virus replication and hla class i upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. | hantaan virus (htnv), the prototype member of the hantavirus genus in the family bunyaviridae, causes hemorrhagic fever with renal syndrome (hfrs) in humans. hemorrhage is due to endothelial barrier damage and a sharp decrease in platelet counts. the mechanisms underlying htnv-associated acute thrombocytopenia have not been elucidated so far. platelets are produced by mature megakaryocytes that develop during megakaryopoiesis. in this study, we show that htnv targets megakaryocytic cells whereas ... | 2010 | 20673746 |
| occupation-related respiratory infections revisited. | occupational pulmonary infectious diseases include tuberculosis (tb) and many viral pathogens, including influenza, coronavirus (severe acute respiratory syndrome or sars), varicella, respiratory syncytial virus, and hantavirus. this review focuses on tb, influenza, and sars, because the published literature is extensive for these 3 infections. the lessons from these 3 are relevant for all nosocomial pulmonary infectious diseases. | 2010 | 20674797 |
| hantavirus infections in humans and animals, china. | hemorrhagic fever with renal syndrome (hfrs) is a serious public health problem in the people's republic of china. although 7 sero/genotypes of hantaviruses have been found in rodents, only hantaan virus (carried by apodemus agrarius mice) and seoul virus (carried by rattus norvegicus rats) reportedly cause disease in humans. during 1950-2007, a total of 1,557,622 cases of hfrs in humans and 46,427 deaths (3%) were reported in china. hfrs has been reported in 29 of 31 provinces in china. after i ... | 2010 | 20678311 |
| prospective study on ocular findings in acute puumala hantavirus infection in hospitalised patients. | to appraise the ocular manifestations of puumala hantavirus evoked haemorrhagic fever with renal syndrome nephropathia epidemica (ne) and to clarify the mechanisms of ocular changes in the largest series of patients examined to date. | 2011 | 20679079 |
| geographical range of rio mamoré virus (family bunyaviridae, genus hantavirus) in association with the small-eared pygmy rice rat (oligoryzomys microtis). | hantavirus htn.007 was originally isolated from a small-eared pygmy rice rat (oligoryzomys microtis) captured in northeastern peru. the results of analyses of nucleotide and amino acid sequence data in this study indicated that htn.007 is a strain of rio mamoré virus (riomv) which is enzootic in small-eared pygmy rice rat populations in bolivia. as such, the results of this study extend our knowledge of the geographical range of riomv and support the notion that the small-eared pygmy rice rat is ... | 2010 | 20687859 |
| natural history of sin nombre virus infection in deer mice in urban parks in oregon. | sin nombre virus (snv), one of at least 45 hantaviruses described worldwide, is hosted by the deer mouse, peromyscus maniculatus, a common species throughout most of north america. herein, we describe general life-history characteristics of deer mice and the ways in which these factors relate to the incidence of snv infections among populations of this host species in and around portland, oregon. in total, 3,175 deer mice were captured from october 2002 to september 2005. transmission of snv app ... | 2010 | 20688636 |
| tnf-α expression and promoter sequences reflect the balance of tolerance/resistance to puumala hantavirus infection in european bank vole populations. | the tumor necrosis factor-alpha (tnf-α) influences the ability to limit parasite infection but its over-production might result in inflammatory disorders. the level of tnf-α gene expression could thus mediate a balance of tolerance/resistance to infections. this study focused on puumala hantavirus (puuv) infection in its rodent host, the bank vole (myodes glareolus). in humans, puuv is responsible of a mild form of hemorrhagic fever with renal syndrome, nephropathia epidemica (ne). the severity ... | 2010 | 20691810 |
| long-term patterns of immune investment by wild deer mice infected with sin nombre virus. | immunocompetence of animals fluctuates seasonally, however, there is little consensus on the cause of these fluctuations. some studies have suggested that these patterns are influenced by changes in reproductive condition, whereas others have suggested that differences result from seasonal variations in energy expenditures. the objective of our study was to examine these contrasting views of immunity by evaluating seasonal patterns of immune response and reproduction in wild populations of deer ... | 2010 | 20695811 |
| infections in the natural environment of british columbia, canada. | the canadian province of british columbia has a luxurious environment, complete with the multitude of wildlife and insects, and would at first glance appear to be suitable for the transmission of diseases in nature communicable to humans. despite this potential, such diseases are relatively uncommon, although several have the potential for serious consequences. attention has been recently focused on hantavirus infection, water-borne toxoplasmosis and parasitic diarrheal diseases, cryptococcosis ... | 2008 | 20701841 |
| travellers and viral haemorrhagic fevers: what are the risks? | viral haemorrhagic fevers (vhf) are caused by zoonotic viral infections transmitted to humans directly or by ticks or mosquitoes. the overall risk to travellers is conservatively estimated at <1 in 1 million travel episodes to african countries where infection is present, and febrile patients returning from these countries are at least 1000 times more likely to have malaria than lassa fever or another vhf. no cases have been reported in fellow travellers exposed to a travelling case and only one ... | 2010 | 20705436 |
| [expression of partial s gene of hantavirus z10 in pichia pastoris]. | the purpose of this study is to express partial s gene of hantavirus z10. | 2009 | 20718348 |
| a possible case of hantavirus infection in a borneo orangutan and its conservation implication. | natural infection of hantavirus in orangutans has never been reported. | 2011 | 20722771 |
| non-human primates in outdoor enclosures: risk for infection with rodent-borne hantaviruses. | different species of non-human primates have been exploited as animal disease models for human hantavirus infections. to study the potential risk of natural hantavirus infection of non-human primates, we investigated serum samples from non-human primates of three species living in outdoor enclosures of the german primate center (gpc), göttingen, located in a hantavirus endemic region of central germany. for that purpose we used serological assays based on recombinant antigens of the bank vole (m ... | 2011 | 20727685 |
| genetic reassortment between high-virulent and low-virulent dobrava-belgrade virus strains. | the tri-segmented rna genome of hantaviruses facilitates genetic reassortment by segment swapping when cells are co-infected with different virus strains. we found efficient in vitro reassortment between members of two different genetic lineages of the dobrava-belgrade virus species, the weakly virulent dobv-aa and highly virulent dobv-af. in all reassortants, s and l segments originated from the same parental strain, and only the m segment was exchanged. to identify functional differences betwe ... | 2010 | 20734125 |
| puumala virus infection: radiologic findings. | a 33-year-old male patient was admitted to our nephrology department with rapidly deteriorating general health, fever, respiratory difficulties, and acute renal failure. computed tomography of the thorax revealed interstitial edema with thickening of the interlobular septa, peribronchial cuffing, ground-glass opacities, and small pleural and pericardial effusions. polymerase chain reaction tests verified puumala virus infection. the patient recovered with supportive treatment. hantavirus infecti ... | 2011 | 20736852 |
| small mammal-associated zoonoses. | 2010 | 20795915 | |
| hantaviruses and their hosts in europe: reservoirs here and there, but not everywhere? | five hantaviruses are known to circulate among rodents in europe, and at least two among insectivores. four (dobrava, saaremaa, seoul, and puumala [puuv] viruses) are clearly associated with hemorrhagic fever with renal syndrome (hfrs). puuv, the most common etiological agent of hfrs in europe, is carried by the bank vole (myodes glareolus), one of the most widespread and abundant mammal species in europe. this host-virus system is among hantaviruses also the most studied one in europe. however, ... | 2010 | 20795916 |
| diagnosis of hantavirus infection in humans and rodents in ribeirão preto, state of são paulo, brazil. | hantavirus pulmonary and cardiovascular syndrome (hpcs) is an emerging serious disease in the americas. hantaviruses (bunyaviridae) are the causative agents of this syndrome and are mainly transmitted through inhalation of aerosols containing the excreta of wild rodents. in the ribeirão preto region (state of são paulo, brazil), hpcs has been reported since 1998, caused by the araraquara virus (arav), for which necromys lasiurus is the rodent reservoir. this study aimed to show diagnostic result ... | 2010 | 20802928 |
| andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of ve-cadherin. | hantavirus pulmonary syndrome (hps) and hemorrhagic fever with renal syndrome (hfrs) are severe diseases associated with hantavirus infection. high levels of virus replication occur in microvascular endothelial cells but without a virus-induced cytopathic effect. however, virus infection results in microvascular leakage, which is the hallmark of these diseases. ve-cadherin is a major component of adherens junctions, and its interaction with the vascular endothelial growth factor (vegf) receptor, ... | 2010 | 20810734 |
| environmental risk factors for haemorrhagic fever with renal syndrome in a french new epidemic area. | summaryin france, haemorrhagic fever with renal syndrome (hfrs) is endemic along the belgian border. however, this rodent-borne zoonosis caused by the puumala virus has recently spread south to the franche-comté region. we investigated the space-time distribution of hfrs and evaluated the influence of environmental factors that drive the hantavirus reservoir abundance and/or the disease transmission in this area. a scan test clearly indicated space-time clustering, highlighting a single-year (20 ... | 2011 | 20822577 |
| circulation of hantaviruses in the influence area of the cuiabá-santarém highway. | we describe evidence of circulation of hantaviruses in the influence area of the santarém-cuiabá highway (br-163) in the brazilian amazon through the prevalence of specific antibodies against hantaviruses in inhabitants living in four municipalities of this area: novo progresso (2.16%) and trairão (4.37%), in state of pará (pa), and gua-rantã do norte (4.74%) and marcelândia (9.43%), in state of mato grosso. we also demonstrate the ongoing association between castelo dos sonhos virus (casv) and ... | 2010 | 20835614 |
| bayou virus detected in non-oryzomyine rodent hosts: an assessment of habitat composition, reservoir community structure, and marsh rice rat social dynamics. | in the united states, bayou virus (bayv) ranks second only to sin nombre virus (snv) in terms of hantavirus pulmonary syndrome (hps) incidents, having been confirmed in cases from texas and louisiana since its discovery in 1994. this study on bayv infection among sympatric, non-oryzomyine rodents ("spillover") in freeport, tx, is the first to link patterns of hantavirus interspecific spillover with the spatiotemporal ecology of the primary host (marsh rice rat, oryzomys palustris). mark-recaptur ... | 2009 | 20836801 |
| microhabitat characteristics of akodon montensis, a reservoir for hantavirus, and hantaviral seroprevalence in an atlantic forest site in eastern paraguay. | hantaviruses may cause serious disease when transmitted to humans by their rodent hosts. since their emergence in the americas in 1993, there have been extensive efforts to understand the role of environmental factors on the presence of these viruses in their host rodent populations. hps outbreaks have been linked to precipitation, but climatic factors alone have not been sufficient to predict the spatial-temporal dynamics of the environment-reservoir-virus system. using a series of mark-recaptu ... | 2009 | 20836810 |
| interaction of hantavirus nucleocapsid protein with ribosomal protein s19. | hantaviruses, members of the bunyaviridae family, are emerging category a pathogens that initiate the translation of their capped mrnas by a novel mechanism mediated by viral nucleocapsid protein (n). n specifically binds to the mrna 5' m7g cap and 40s ribosomal subunit, a complex of 18s rrna and multiple ribosomal proteins. here, we show that n specifically interacts with the ribosomal protein s19 (rps19), located at the head region of the 40s subunit. we suggest that this n-rps19 interaction f ... | 2010 | 20844026 |
| antagonism of type i interferon responses by new world hantaviruses. | evasion of interferon (ifn)-mediated antiviral signaling is a common defense strategy for pathogenic rna viruses. to date, research on ifn antagonism by hantaviruses is limited and has focused on only a subset of the numerous recognized hantavirus species. the host ifn response has two phases, an initiation phase, resulting in the induction of alpha/beta ifn (ifn-α/β), and an amplification phase, whereby ifn-α/β signals through the jak/stat pathway, resulting in the establishment of the cellular ... | 2010 | 20844031 |
| andes virus regulation of cellular micrornas contributes to hantavirus-induced endothelial cell permeability. | hantaviruses infect human endothelial cells (ecs) and cause two diseases marked by vascular permeability defects, hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). vascular permeability occurs in the absence of ec lysis, suggesting that hantaviruses alter normal ec fluid barrier functions. ecs infected by pathogenic hantaviruses are hyperresponsive to vascular endothelial growth factor (vegf), and this alters the fluid barrier function of ec adherens junctions ... | 2010 | 20844033 |
| extinction of refugia of hantavirus infection in a spatially heterogeneous environment. | we predict an abrupt observable transition, on the basis of numerical studies, of hantavirus infection in terrain characterized by spatially dependent environmental resources. the underlying framework of the analysis is that of fisher equations with an internal degree of freedom, the state of infection. the unexpected prediction is of the sudden disappearance of refugia of infection in spite of the existence of supercritical (favorable) food resources, brought about by reduction of their spatial ... | 2010 | 20866661 |
| acute undifferentiated febrile illness in adult hospitalized patients: the disease spectrum and diagnostic predictors - an experience from a tertiary care hospital in south india. | local prevalences of individual diseases influence the prioritization of the differential diagnoses of a clinical syndrome of acute undifferentiated febrile illness (afi). this study was conducted in order to delineate the aetiology of afi that present to a tertiary hospital in southern india and to describe disease-specific clinical profiles. an 1-year prospective, observational study was conducted in adults (age >16 years) who presented with an undifferentiated febrile illness of duration 5-21 ... | 2010 | 20870680 |
| smoking and other risk factors for hantavirus infections: the whole story. | 2010 | 20875215 |