Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [a review about nephropathia epidemica]. | we propose a review of history, aetiology, physiopathology, clinical features, treatment and prevention of nephropathia epidemica (ne) which represents the only form of hantavirus infection in belgium. | 2006 | 16910256 |
| mathematical models for hantavirus infection in rodents. | hantavirus pulmonary syndrome is an emerging disease of humans that is carried by wild rodents. humans are usually exposed to the virus through geographically isolated outbreaks. the driving forces behind these outbreaks is poorly understood. certainly, one key driver of the emergence of these viruses is the virus population dynamics within the rodent population. two new mathematical models for hantavirus infection in rodents are formulated and studied. the new models include the dynamics of sus ... | 2006 | 16794943 |
| a history of biological disasters of animal origin in north america. | this paper examines past occurrences in north america relevant to the possibility of biological disasters with animal origins. with respect to naturally occurring animal disease outbreaks, north america, while not as adversely affected by epizootics as other regions, has had its fair share of such outbreaks of both 'traditional' and emerging animal diseases. the traditional category includes such diseases as anthrax, classical swine fever, bluetongue, brucellosis, foot and mouth disease, and the ... | 2006 | 16796038 |
| hemorrhagic fever with renal syndrome complicated with pregnancy: a case report. | hantaviruses cause two forms of human disease: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome. hantavirus infection can occur in pregnant women and it can have an influence on the maternal and fetal outcomes, although this is a rare finding even in endemic areas. we describe here a recent case of hfrs complicating pregnancy. | 2006 | 16913449 |
| laboratory study on the immobilization of bacterial spores in arid environments. | in this study, two effective, non-toxic, wind erosion palliative materials were analyzed for their efficacy in preventing the spread of bacterial spores. desert sand was employed in a laboratory setting with a non-toxic simulant bacterium in an attempt to accurately represent the spreadability of the hantavirus. spore simulants were used instead of viruses due to availability, decreased susceptibility to desiccation and detection ability without involving tissue cultures. the simulant was used t ... | 2006 | 16779932 |
| evaluation of promed-mail as an electronic early warning system for emerging animal diseases: 1996 to 2004. | to identify emerging animal and zoonotic diseases and associated geographic distribution, disease agents, animal hosts, and seasonality of reporting in the program for monitoring emerging diseases (promed)-mail electronic early warning system. | 2006 | 17014355 |
| tick-borne encephalitis virus in clethrionomys glareolus in the czech republic. | a total of 474 specimens from 157 rodents caught at the military training area of boletice in the south of the czech republic from may to november 1999 were screened for tbev by nested pcr. tbev-specific rna was amplified from lung, kidney, and spleen derived from one clethrionomys glareolus in the first rt-pcr round. sequence analysis revealed a 100% identity to the tbev strain neudoerfl. tbev presence in the sample was confirmed by mouse brain passage of backup samples and cell culture. the re ... | 2006 | 17187572 |
| maternal antibodies postpone hantavirus infection and enhance individual breeding success. | the transfer of maternal antibodies from mother to progeny is a well-known phenomenon in avian and mammalian species. optimally, they protect the newborn against the pathogens in the environment. the effect of maternal antibodies on microparasite transmission dynamics may have important consequences for both the fitness of the host and the epizootic processes of the pathogens. however, there is a scarcity of studies examining these effects in free-living wild species. we studied the influence of ... | 2006 | 17015326 |
| development of novel immunoglobulin g (igg), iga, and igm enzyme immunoassays based on recombinant puumala and dobrava hantavirus nucleocapsid proteins. | human infections with asian and european hantaviruses can result in hemorrhagic fever with renal syndromes of differing severities characterized by renal dysfunction and sometimes by pulmonary symptoms. for the serological detection of human infections by hantaviruses relevant for europe, we developed monoclonal antibody capture immunoglobulin g (igg) and iga enzyme-linked immunosorbent assays (elisas) based on yeast-expressed nucleocapsid proteins of puumala and dobrava hantaviruses. moreover, ... | 2006 | 17021245 |
| mild course of puumala nephropathy in children in an area with sporadic occurrence hantavirus infection. | the first three children with puumala virus nephropathy diagnosis in the czech republic are reported on. a boy and two girls were admitted with symptoms of interstitial nephritis. the medical history in all children revealed flu-like symptoms. all patients were mildly pyrexial and had elevated erythrocytes sedimentation rate, c-reactive protein and low hemoglobin levels. serum creatinine levels were elevated and proteinuria exceeded 700 mg/l in all children. tubular proteinuria, glycosuria, high ... | 2006 | 17024393 |
| dynamics of puumala virus infection in bank voles in ardennes department (france). | the hantaviruses (genus hantavirus, family bunyaviridae) include human pathogens and occur worldwide. in western and central europe, the predominant serotype is puumala (puu) virus, which causes epidemic nephropathy. voles are considered to be the main reservoir and the vector of puu virus. a total of 719 rodents (mainly clethrionomys glareolus, apodemus sp.) trapped by capture-mark-recapture (cmr) in four sites in ardennes department (france) between april 2004 and october 2005 were tested for ... | 2006 | 17027178 |
| sin nombre viral rna load in patients with hantavirus cardiopulmonary syndrome. | to address the role that viral load plays in pathogenesis in patients with hantavirus cardiopulmonary syndrome (hcps), we quantified sin nombre virus s segment viral rna in plasma samples from 27 acutely ill patients. for 6 patients, we examined viral load in matched plasma, urine, and/or tracheal aspirate throughout the time when the patients were in intensive care. peak titers in plasma reached 1.8 x 106 copies/ml; none of the patients had viral rna in urine. titers in tracheal aspirates did n ... | 2006 | 17054070 |
| genetic analysis of thailand hantavirus in bandicota indica trapped in thailand. | sixty one tissue samples from several rodent species trapped in five provinces of thailand were examined for the presence of hantaviral markers by enzyme-immunoassay and immunoblotting. four samples, all from the great bandicoot rat bandicota indica, were confirmed positive for the hantaviral n-antigen. two of them were trapped in nakhon pathom province, the other two in nakhon ratchasima province, approximately 250 km from the other trapping site. when analysed by rt-nested pcr, all four rodent ... | 2006 | 16953877 |
| the pathogenic ny-1 hantavirus g1 cytoplasmic tail inhibits rig-i- and tbk-1-directed interferon responses. | hantaviruses cause two diseases with prominent vascular permeability defects, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. all hantaviruses infect human endothelial cells, although it is unclear what differentiates pathogenic from nonpathogenic hantaviruses. we observed dramatic differences in interferon-specific transcriptional responses between pathogenic and nonpathogenic hantaviruses at 1 day postinfection, suggesting that hantavirus pathogenesis may in part be de ... | 2006 | 16973572 |
| update on emerging infections from the centers for disease control and prevention. hantavirus pulmonary syndrome--five states, 2006. | 2006 | 17061318 | |
| tropical infections in the icu. | certain arthropod-borne infections are common in tropical regions because of favorable climatic conditions. water-borne infections like leptospirosis are common due to contamination of water especially during the monsoon floods. infections like malaria, leptospirosis, dengue fever and typhus sometimes cause life threatening organ dysfunction and have several overlapping features. most patients present with classicial clinical syndromes: fever and thrombocytopenia are common in dengue, malaria an ... | 2006 | 16944613 |
| characterization of shock in a hamster model of hantavirus infection. | human hantavirus cardiopulmonary syndrome (hcps) due to andes, sin nombre and other hantaviruses is characterized by severe pulmonary capillary leak and cardiogenic shock. hamsters, the only animal manifesting hcps-like disease, were instrumented with radiotelemeters that enabled ambulatory intracarotid blood pressure recording within an animal biosafety level-4 facility. following infection with andes virus, blood pressure and heart rate decreased slowly in a biphasic manner during the first 7 ... | 2006 | 16950493 |
| regions of importance for interaction of puumala virus nucleocapsid subunits. | puumala virus (puuv) is a hantavirus that causes a mild form of hemorrhagic fever with renal syndrome in northern and central europe, and in large parts of russia. the nucleocapsid (n) protein encoded by hantaviruses plays an important role in the life-cycle of these viruses, and one important function for the n-protein is to oligomerize, surround and protect the viral rnas. we have identified amino- and carboxy-terminal regions involved in puuv n-n interactions, which comprise amino acids 100-1 ... | 2006 | 16972031 |
| characterization of a new puumala virus genotype associated with hemorrhagic fever with renal syndrome. | hantavirus serotype puumala (puuv) is the etiologic agent of nephropathia epidemica (ne), a mild variant of hemorrhagic fever with renal syndrome (hfrs) in europe, with lethality rates up to 1% among human patients. the serotype puuv is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. we describe a new, geographically and phylogenetically well-defined pathogenic puuv sublineage in southwest germany (st ... | 2006 | 16972039 |
| [the new-world hantaviruses. ecology and epidemiology of an emerging virus in latin america]. | the hantaviruses are a group of emerging rodent-borne pathogens (family bunyaviridae; genus hantavirus) that are etiologic agents for hemorrhagic fever with renal syndrome (hfrs) in europe and asia and hantavirus cardiopulmonary syndrome (hcps) in the americas. hfrs is associated with rodents of the family muridae, subfamilies murinae and arvicolinae; hps is associated with rodents of the subfamily sigmodontinae. since the identification of hcps in usa in 1993, a large number of cases of hps and ... | 2006 | 16977974 |
| [emergence of new pneumonia: besides severe acute respiratory syndrome]. | important epidemiological modifications have been registered in respiratory infections, both in immunocompetent and immunocompromised hosts. pathogens with modified antibiotic susceptibility patterns have emerged, which display an increased antibiotic resistance, such as s. pneumoniae, s. aureus, h. influenzae. this trait has a strong impact on the therapeutic choices, particularly when an empiric antibiotic treatment is selected. the prevalence of bacterial species showing non-susceptibility to ... | 2006 | 17146421 |
| [isolation and characterization of hantavirus carried by rodents in huludao, liaoning province]. | to investigate the hantavirus infection and their genotype in rodents in huludao. | 2006 | 17152513 |
| serological survey for viral pathogens in turkish rodents. | wild rodents (n = 330) were trapped around the villages of altindere and coşandere (maçka, trabzon province), ayder, ortan, and yolkiyi (camlihemşin, rize province), and bozdag (odemiş, izmir province) in northeastern and western turkey during april 2004. samples were tested for arenavirus, hantavirus, and cowpox virus (family poxviridae, genus orthopoxvirus, cpxv) antibodies by using immunofluorescence assays (ifas). antibodies against arenaviruses were found in eight of 330 (2.4%) rodents. are ... | 2006 | 17092901 |
| catacamas virus, a hantaviral species naturally associated with oryzomys couesi (coues' oryzomys) in honduras. | the primary objective of this study was to extend our knowledge of the geographical distribution, genetic diversity, and natural host associations of the hantaviruses indigenous to north america. antibody to a hantavirus was found in 5 (20.8%) of 24 coues' oryzomys (oryzomys couesi) and none of 41 other rodents captured near the town of catacamas in eastern honduras, and a hantavirus was isolated from one of the antibody-positive coues' oryzomys. analyses of nucleotide and amino acid sequence da ... | 2006 | 17124003 |
| [study on the coinfection of hantavirus and orientia tsutsugamushi in tissue cell culture]. | to investigate the possibility of hantavirus (hv) and orientia tsutsugamushi (ot) coinfection in their hosts. | 2006 | 17152514 |
| tumor necrosis factor-alpha genetic predisposing factors can influence clinical severity in nephropathia epidemica. | severe human infection with hantavirus is characterized by high fever, cold chills, thrombocytopenia, arterial hypotension, acute renal failure, and/or adult respiratory distress syndrome (ards)-like pulmonary involvement, but the clinical course varies greatly between individuals. we investigated whether genetically determined differences in tumor necrosis factor (tnf)-alpha production can influence the severity of hantavirus disease. we studied a tnf-alpha single-nucleotide promoter polymorphi ... | 2006 | 16987073 |
| implication of phylogenetic systematics of rodent-borne hantaviruses allows understanding of their distribution. | hantaviruses' distribution is reassessed after performing a cladistic analysis on 93 strains isolated from rodents, and one used as outgroup: thottapalayam isolated from a shrew. while most hantaviruses found in wild animals were collected in northern asia, europe, north america, and south america, only thottapalayam and thailand were found in south and southeastern asia. thottapalayam is highly divergent from the other known hantaviruses and may represent the emerging tip of a different lineage ... | 2006 | 17135493 |
| emergency medicine and the public's health: emerging infectious diseases. | in recent years, multiple global forces have contributed to the emergence and widespread distribution of previously unknown disease entities. this article discusses ebola virus, west nile virus, and hantavirus as representative emerging infectious diseases. smallpox is discussed along with concerns about the safety of the smallpox vaccine, given the uncertain risk of bioterrorism and smallpox exposure. ed physicians must become familiar with the presentation, management, and public health impact ... | 2006 | 16982350 |
| developing global climate anomalies suggest potential disease risks for 2006-2007. | el niño/southern oscillation (enso) related climate anomalies have been shown to have an impact on infectious disease outbreaks. the climate prediction center of the national oceanic and atmospheric administration (noaa/cpc) has recently issued an unscheduled el niño advisory, indicating that warmer than normal sea surface temperatures across the equatorial eastern pacific may have pronounced impacts on global tropical precipitation patterns extending into the northern hemisphere particularly ov ... | 2006 | 17194307 |
| changes in sin nombre virus antibody prevalence in deer mice across seasons: the interaction between habitat, sex, and infection in deer mice. | we examined the impact of season and habitat on sin nombre virus (snv) seroprevalence in deer mice (peromyscus maniculatus) in utah's great basin desert from may 2002 through summer 2003. low mouse captures in 2002 limited analysis for that year. in two seasons during 2003, mouse density and sagebrush cover were positively linked (spring: r = 0.8, p = 0.01; summer: r = 0.8, p = 0.04). in the spring, seroprevalence was negatively correlated with density (r = -0.9, p< 0.01); male and female antibo ... | 2006 | 17255449 |
| deer mouse movements in peridomestic and sylvan settings in relation to sin nombre virus antibody prevalence. | prevalence of antibody to sin nombre virus (snv) has been found to be nearly twice as high in deer mice (peromyscus maniculatus) in peridomestic settings as in sylvan settings in two studies in montana and one in new mexico. we investigated whether this difference may be related to a difference in deer mouse movements in the two settings. we used radiotelemetry to determine home range size and length of movement for 22 sylvan (1991-1992) and 40 peridomestic deer mice (1995-1999). we also determi ... | 2006 | 17255448 |
| [hantavirus in zulia state?]. | during the last years, there has been a worldwide rise in the number of infectious diseases caused by newly discovered agents, in some cases and in others, by variants known as emergent or reemergent pathogens. the analysis of the nucleotide sequences of four rna-positive hantaviruses (s. altoni) suggests that the caño delgadito virus is widely distributed in the venezuelan plains. a similar distribution has been found for some isolates and strains of a novel hantavirus (proposed name "mamporal" ... | 2006 | 17176900 |
| phylogenetic and geographical relationships of hantavirus strains in eastern and western paraguay. | recently, we reported the discovery of several potential rodent reservoirs of hantaviruses in western (holochilus chacarius) and eastern paraguay (akodon montensis, oligoryzomys chacoensis, and o. nigripes). comparisons of the hantavirus s- and m-segments amplified from these four rodents revealed significant differences from each another and from other south american hantaviruses. the alp strain from the semiarid chaco ecoregion clustered with leguna negra and rio mamore (ln/rm), whereas the bm ... | 2006 | 17172380 |
| use of igg avidity to indirectly monitor epizootic transmission of sin nombre virus in deer mice (peromyscus maniculatus). | an igg avidity assay was developed to differentiate deer mice that had recently acquired sin nombre virus (snv) from those that were infected in the distant past. using this procedure, low avidity antibodies were predominantly detected in experimentally infected deer mice (89.5%) within the first 30 days post-inoculation. the assay was then applied to sera from naturally infected deer mice collected during a field investigation associated with a cluster of hantavirus pulmonary syndrome cases. a ... | 2006 | 17172381 |
| hantavirus cardiopulmonary syndrome: immune response and pathogenesis. | hantaviruses are emerging viruses in the americas that cause cardiopulmonary syndrome with high lethality. the intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. on the other hand, the humoral immune response seems to be essential for recovery from infection. | 2006 | 16793309 |
| crimean-congo haemorrhagic fever presenting as thrombotic microangiopathy and acute renal failure. | 2006 | 16735392 | |
| modeling hantavirus reservoir species dominance in high seroprevalence areas on the azuero peninsula of panama. | habitat fragmentation commonly influences distribution of zoonotic disease reservoirs. in panama, populations of rodent hosts of hantaviruses are favored by small habitat fragments isolated by agricultural lands. we expected a similar relationship between landscape characteristics and host distribution at fine geographical scales in southern panama. the relative abundance of zygodontomys brevicauda, the primary host for "calabazo" virus, and other rodents was assessed at 24 sites within the azue ... | 2006 | 16760528 |
| neutralizing antibodies in survivors of sin nombre and andes hantavirus infection. | we evaluated titers of homotypic and heterotypic neutralizing antibodies (nabs) to andes and sin nombre hantaviruses in plasma samples from 20 patients from chile and the united states. all but 1 patient had high titers of nab. none of the plasma samples showed high titers against the heterologous virus. | 2006 | 16494739 |
| corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by puumala virus infection. | reported here are two cases of hantavirus pulmonary syndrome caused by puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. these cases emphasize the role of the inflammatory response in the pathogenesis of hantavirus pulmonary syndrome. | 2006 | 16550348 |
| is there an association of pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in finland? | as part of studies on the nature of the endemic virus infections in natural rodent hosts, the possible association of cyst forms of pneumocystis spp. with the presence of hanta-, cowpox-, and arenavirus antibodies in wild mice (apodemus flavicollis, n=105; apodemus agrarius, n=63; micromys minutus, n=50) and the common shrew (sorex araneus, n=101) was studied in south-central finland. one hantavirus (saaremaa virus, saav) seropositive a. agrarius, and 2 cowpoxvirus (cpxv) seropositive s. araneus ... | 2006 | 16556344 |
| bidirectional virus secretion and nonciliated cell tropism following andes virus infection of primary airway epithelial cell cultures. | hantavirus pulmonary syndrome (hps) is an acute disease resulting from infection with any one of a number of new world hantaviruses. hps has a mortality rate of 40% and, unlike many other severe respiratory diseases, often occurs in young, healthy adults. infection is usually initiated after inhalation of rodent excreta containing virus particles, but human-to-human transmission has been documented. postmortem tissue samples show high levels of viral antigen within the respiratory endothelium, b ... | 2006 | 16414986 |
| which hantaviruses in india ? | 2006 | 16567875 | |
| hantaan/andes virus dna vaccine elicits a broadly cross-reactive neutralizing antibody response in nonhuman primates. | at least four hantavirus species cause disease with prominent renal involvement-hemorrhagic fever with renal syndrome (hfrs); and several hantavirus strains cause disease with significant pulmonary involvement-hantavirus pulmonary syndrome (hps). the most prevalent and lethal hantaviruses associated with hfrs and hps are hantaan virus (htnv) and andes virus (andv), respectively. here, we constructed a dna vaccine plasmid (pwrg/ha-m) that contains both the htnv and andv m gene segments. rhesus ma ... | 2006 | 16378630 |
| production of hantavirus puumala nucleocapsid protein in saccharomyces cerevisiae for vaccine and diagnostics. | the production of hantavirus puumala nucleocapsid (n) protein for potential applications as a vaccine and for diagnostic purposes was investigated with saccharomyces cerevisiae as a recombinant host. the n protein gene and the hexahistidine tagged n (h-n) protein gene were expressed intracellular from a 2-microm plasmid vectors under the control of a fused galactose inducible gal10-pyk promoter. for monitoring the recombinant gene expression, a h-n and a gfp fusion protein was used. different cu ... | 2006 | 16513199 |
| dobrava, but not saaremaa, hantavirus is lethal and induces nitric oxide production in suckling mice. | hantaviruses are the causative agents of hfrs and hcps (hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome), two severe, and often fatal human diseases. mortality from hfrs varies between hantaviruses; hantaan and dobrava show the highest, seoul intermediate, and puumala low mortality. saaremaa, genetically closely related to dobrava, is also known to induce hfrs, with low or no mortality. in this study, mice were inoculated with dobrava and saaremaa viruses to test fo ... | 2006 | 16513381 |
| saaremaa hantavirus should not be confused with its dangerous relative, dobrava virus. | 2006 | 16597913 | |
| ten-year prognosis of puumala hantavirus-induced acute interstitial nephritis. | nephropathia epidemica (ne) is a hemorrhagic fever with renal syndrome caused by puumala hantavirus. its long-term prognosis is considered favorable. there are, however, some reports about subsequent hypertension, glomerular hyperfiltration, and proteinuria after previous hantavirus infection. therefore, we studied 36 patients 5 and 10 years after acute ne, with 29 seronegative controls. office blood pressure, ambulatory 24-h blood pressure (abp), glomerular filtration rate (gfr), and proteinuri ... | 2006 | 16641933 |
| [identification of infectious agents in cases suspicious of hantavirus infection but with negative serology]. | the diagnosis of acute respiratory illness caused by hantavirus is based in the rapid and progressive clinical course, epidemiological background and the serological confirmation of the virus. when the presence of the virus is not confirmed a differential diagnosis must be made with other infections. between 1999 and 2001, the chilean public health institute received 1063 blood samples from patients with a suspicious clinical picture, to study the presence of andes strain of hantavirus. in 134 o ... | 2006 | 16676106 |
| hantavirus and arenavirus antibody prevalence in rodents and humans in trentino, northern italy. | the spatial and temporal distribution of hantavirus and arenavirus antibody-positive wild rodents in trentino, italy, was studied using immunofluorescence assays (ifa) in two long-term sites trapped in 2000-2003, and six other sites trapped in 2002. the overall hantavirus seroprevalence in the bank voles, clethrionomys glareolus (n=229) screened for puumala virus (puuv) antibodies was 0.4%, and that for apodemus flavicollis mice (n=1416) screened for dobrava virus (dobv) antibodies was 0.2%. ant ... | 2006 | 16371172 |
| soochong virus: an antigenically and genetically distinct hantavirus isolated from apodemus peninsulae in korea. | hantaan (htn) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (hfrs), was first isolated in 1976 from lung tissue of a striped-field mouse (apodemus agrarius) captured in songnae-ri, gyeonggi province, republic of korea. found primarily in mountainous areas, the korean field mouse (a. peninsulae) is the second-most dominant field rodent species found throughout korea. a new hantavirus, designated soochong (soo), was isolated in vero e6 cells from four a. pen ... | 2006 | 16372283 |
| targeting vascular injury using hantavirus-pseudotyped lentiviral vectors. | restenosis is a pathological condition involving intimal hyperplasia and negative arterial remodeling. gene therapy vectors have shown modest therapeutic effects, but the level of infectivity has been relatively poor. in the present study we have designed a modified lentiviral vector (lv) pseudotyped with a strain of hantavirus (htnv) to improve the transduction efficiency into vascular smooth muscle and endothelial cells in vitro and in vivo. in vivo studies using adult new zealand white rabbit ... | 2006 | 16431160 |
| a pseudotype vesicular stomatitis virus containing hantaan virus envelope glycoproteins g1 and g2 as an alternative to hantavirus vaccine in mice. | we examined whether a vesicular stomatitis virus (vsv) pseudotype bearing the hantavirus envelope glycoproteins (gps) g1 and g2 (vsvdeltag*htn) could be used as a safe and effective alternative to native hantavirus. mice were immunized with purified particles of vsvdeltag*htn. after the second immunization, all mice produced anti-gp antibody as detected in elisa and a neutralization test. after the third immunization, the mice were challenged with hantaan virus. neither anti-np antibody producti ... | 2006 | 16426712 |
| biological control agents elevate hantavirus by subsidizing deer mouse populations. | biological control of exotic invasive plants using exotic insects is practiced under the assumption that biological control agents are safe if they do not directly attack non-target species. we tested this assumption by evaluating the potential for two host-specific biological control agents (urophora spp.), widely established in north america for spotted knapweed (centaurea maculosa) control, to indirectly elevate sin nombre hantavirus by providing food subsidies to populations of deer mice (pe ... | 2006 | 16623730 |
| a friday afternoon case of apparent anti-glomerular basement nephritis. | 2006 | 16644771 | |
| microbiological contamination of laboratory mice and rats in korea from 1999 to 2003. | to survey the microbiological contamination of laboratory mice and rats in korea during a 5-year period, we monitored animals housed in mouse and rat facilities with either barrier or conventional systems. at barrier and conventional mouse facilities, the most important pathogen identified was mouse hepatitis virus (mhv), while mycoplasma pulmonis was the most important pathogen at conventional rat facilities. interestingly, hantavirus was recovered from both barrier and conventional mouse facil ... | 2006 | 16508207 |
| a new puumala hantavirus subtype in rodents associated with an outbreak of nephropathia epidemica in south-east germany in 2004. | a micro-epidemic of hantavirus infections occurred in lower bavaria, south-east germany, starting in april 2004. while only three cases were registered from 2001 to 2003, a dramatically increased number of clinically apparent human hantavirus infections (n=38) was observed in 2004, plus seven additional cases by june 2005. to determine the reservoir responsible for the infections, a total of 43 rodents were trapped in lower bavaria. serological and genetic investigations revealed that puumala vi ... | 2006 | 16650330 |
| [study of phylogenetic relations of hantaviruses by using the mutual information method. tula genotype viruses]. | phylogenetic relations were studied in the group of tula viruses (hantavirus genus, bunyaviridae family) of eurasia. the similarity in the nucleotide sequences of segments was estimated by the value of mutual information. the application of this method confirmed that recombinant events might occur in some tula-like viruses of eurasia, as previously presumed by the results of bootscanning and analysis of amino acid sequences. it was found that might be recombination between distinct phylogenetic ... | 2006 | 16826755 |
| the effect of biodiversity on the hantavirus epizootic. | we analyze a mathematical model of the epizootic of hantavirus in mice populations, including the effect of species that compete with the host. we show that the existence of the second species has an important consequence for the prevalence of the infectious agent in the host. when the two mice species survive in the ecosystem, the competitive pressure of the second species may lead to reduction or complete elimination of the prevalence of infection. the transition between the disappearance of t ... | 2006 | 16676531 |
| [viral hemorrhagic fevers in brazil]. | to call attention to viral hemorrhagic fevers, diseases that are mostly underdivulged and, probably, underreported, we present here case reports of the 4 diseases of this kind that occur in brazil: yellow fever, dengue haemorrhagic fever/dengue shock syndrome, arenavirus haemorrhagic fever and hantavirus cardiopulmonary syndrome. relevant clinical, epidemiological and laboratorial diagnostic aspects of these viral haemorrhagic fevers are also shown here. these diseases have a high case fatality ... | 2006 | 16699651 |
| hantavirus in african wood mouse, guinea. | hantaviruses are rodent-borne, emerging viruses that cause life-threatening human diseases in eurasia and the americas. we detected hantavirus genome sequences in an african wood mouse (hylomyscus simus) captured in sangassou, guinea. sequence and phylogenetic analyses of the genetic material demonstrate a novel hantavirus species, which we propose to name "sangassou virus." | 2006 | 16704849 |
| truncated recombinant dobrava hantavirus nucleocapsid proteins induce strong, long-lasting immune responses in mice. | we describe the cloning and expression of dobrava hantavirus (dobv) nucleocapsid proteins and a truncated form consisting of the first 118 n-terminal amino acids, and the capacity of these e. coli icone 200-expressed recombinant proteins (rnp) to induce a protective immune response against dobv in mice. as an alternative carrier protein, the outer membrane protein a derived from klebsiella pneumoniae (rp40) has been coupled to different rnp constructs. all recombinant proteins were found to be h ... | 2006 | 16714853 |
| hantavirus pulmonary syndrome--five states, 2006. | hantavirus pulmonary syndrome (hps) is a rodentborne viral disease characterized by severe pulmonary illness and a case-fatality ratio of 30%-40%. sin nombre virus causes the majority of hps cases in the united states, and the deer mouse (peromyscus maniculatus) is its predominant reservoir. this report describes an increase in human cases of hps reported during january-march 2006 from arizona, new mexico, north dakota, texas, and washington state. the findings emphasize the need for renewed att ... | 2006 | 16760891 |
| characterization of truncated hantavirus nucleocapsid proteins and their application for serotyping. | hemorrhagic fever with renal syndrome (hfrs) is a fulminant infectious disease characterized by fever, hemorrhage, renal impairment, and thrombocytopenia. hantaviruses associated with this belong to different serotypes: hantaan (htn), seoul (seo), dobrava/belgrade (dob), and puumala (puu). the first two, htn and seo, are endemic in china. to investigate the epidemiology of hfrs and virus transmission in china, we constructed prokaryotic plasmids encoding truncated recombinant htn and seo nucleoc ... | 2006 | 16721853 |
| [investigation on hantaviruses infection in rodents from free markets in beijing areas]. | in order to find out the factors related to hemorrhagic fever with renal syndrome (hfrs) infection, and to evaluate the probability of ecdemic hantaviruses (hv) infection in rodents in beijing areas. | 2006 | 16749997 |
| phylogeography of the deer mouse (peromyscus maniculatus) provides a predictive framework for research on hantaviruses. | phylogeographical partitioning of sin nombre and monongahela viruses (hantaviruses) may reflect that of their primary rodent host, the deer mouse (peromyscus maniculatus). lack of a comprehensive assessment of phylogeographical variation of the host has precluded the possibility of predicting spatial limits of existing strains of these viruses or geographical regions where novel viral strains might emerge. the complete cytochrome b gene was sequenced for 206 deer mice collected from sites throug ... | 2006 | 16760402 |
| characterization of the rna chaperone activity of hantavirus nucleocapsid protein. | hantaviruses are tripartite negative-sense rna viruses and members of the bunyaviridae family. the nucleocapsid (n) protein, encoded by the smallest of the three genome segments (s), has nonspecific rna chaperone activity. this activity results in transient dissociation of misfolded rna structures, may be required for facilitating correct higher-order rna structure, and may function in viral genome replication. we carried out a series of experiments to further characterize the ability of n to di ... | 2006 | 16775315 |
| a novel method for cloning of non-cytolytic viruses. | hantaviruses are rodent-borne pathogens with a segmented single-stranded rna genome of negative polarity. spontaneous occurrence of variants with genetic heterogeneity have been observed both in vivo and in vitro. the objective of this study was to establish a method for the cloning of genetically homogenous hantaviruses which can be used for subsequent functional studies. infected veroe6 cells were incubated with an agarose/medium overlay to prevent uncontrolled distribution of de novo synthesi ... | 2006 | 16504312 |
| serological assays for the detection of human andes hantavirus infections based on its yeast-expressed nucleocapsid protein. | the objective of the study was to develop and evaluate igm and igg elisas and an igg western blot test for the serological detection of human infections with andes virus (andv), the major cause of hantavirus cardiopulmonary syndrome (hcps) in south america. | 2006 | 16428893 |
| generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles. | foreign protein sequences presented on hamster polyomavirus (hapyv) major capsid protein vp1-derived virus-like particles (vlps) have been demonstrated to be highly immunogenic. the current study was aimed to evaluate vp1-derived chimeric vlps as tools for hybridoma technology to generate monoclonal antibodies (mabs) of desired specificity. chimeric vlps containing inserts of different size and origin were used as immunogens. chimeric vlps carrying a 9 amino acid (aa)-long cytotoxic t-cell epito ... | 2006 | 16516908 |
| first evidence of fatal hantavirus nephropathy in india, mimicking leptospirosis. | 2006 | 16361279 | |
| replication and immunoactivity of the recombinant peromyscus maniculatus cytomegalovirus expressing hantavirus g1 glycoprotein in vivo and in vitro. | previously, we have shown that cmv isolated from deer mouse could be used in vivo and in vitro to express sin nombre virus (snv) glycoprotein g1 in deer mice [rizvanov aa, van geelen ag, morzunov s, et al. generation of a recombinant cytomegalovirus for expression of a hantavirus glycoprotein. j.virol. 2003;77(22):12203-10]. in this report, we further characterize replication of wild-type (wt) and recombinant peromyscus cmv (pcmv) in vivo and in vitro using realtime pcr, and infectious center as ... | 2006 | 16125285 |
| cellular entry of hantaan virus a9 strain: specific interactions with beta3 integrins and a novel 70kda protein. | cellular entry of pathogenic hantaviruses had been shown to be mediated by beta3 integrins. however, no direct evidence exists that hantavirus binds to beta3 integrins, and integrin beta3 subunit is not expressed on some cells permissive to hantavirus infection. in this report, utilizing beta3-integrin-transfected cho cells, we demonstrated that integrin beta3 subunit renders cho cells susceptible to chinese hantaan virus (htn) strain a9 (isolated in china), and the viral infection was correspon ... | 2006 | 16310165 |
| [progress on the study of biological characteristic of hantavirus]. | 2006 | 17299972 | |
| wildlife, environment and (re)-emerging zoonoses, with special reference to sylvatic tick-borne zoonoses in north-western italy. | over the last century, changes in land-use, modification of agriculture-livestock production systems, disruption of wildlife habitats, increase of human activities, higher frequency of international and intercontinental travels, wider circulation of animals and animal products have contributed to alter the distribution, presence and density of hosts and vectors. as a result, the number of emerging and reemerging diseases, including zoonoses, have greatly increased. some infectious pathogens, ori ... | 2006 | 17361062 |
| [haemorrhagic fever with renal syndrome (hfrs)--hantavirus infection disease appearing in poland]. | authors take up the problem of occurrence of the haemorrhagic fever with renal syndrome in poland and present the measures undertaken by chief sanitary inspectorate, which brought to detection of the first, serologically confirmed case of hfrs in may 2005. they strongly emphasize the existence of the disease on polish territory despite the poor epidemiological recognition, an possibility of its testing. | 2006 | 17345831 |
| [a case of haemorrhagic fever with renal syndrome (hfrs)]. | in our article we describe clinical and epidemiological analysis of the first case of haemorrhagic fever with renal syndrome (hfrs)--with serological confirmation--in poland. | 2006 | 17345843 |
| [surveillance on natural infection of rodents with hantavirus in shenzhen city and identification of a hantavirus strain sz2083]. | for clarifying the situation of the natural infection of rodents having hemorrhagic fever with renal syndrome (hfrs) virus and to type hantavirus (hv) using molecular technique in shenzhen city in 2005, and offering guidance for prevention and control of hfrs. | 2006 | 17402203 |
| detection of dobrava hantaviruses in apodemus agrarius mice in the transdanubian region of hungary. | dobrava hantavirus (dobv) belongs to the genus hantavirus of the family bunyaviridae, and is carried by yellow necked and striped field mice (apodemus flavicollis and apodemus agrarius), respectively. the aim of this study was to detect and genetically characterize new dobv strains in rodents captured in the transdanubian region of hungary. rodent corpses were dissected and lung tissues were used for hantavirus detection by sybr green-based real-time rt-pcr using specific primers located in the ... | 2007 | 17524512 |
| nucleotide sequence characterization and phylogenetic analysis of hantaviruses isolated in shandong province, china. | china is the most severe endemic area of hemorrhagic fever with renal syndrome (hfrs) in the world with 30,000-50,000 cases reported annually, which accounts for more than 90% of total number of cases worldwide. the incidence rate of the syndrome in shandong province is one of the highest in china, which has ever reached 50 per 100,000 persons per year. however, the molecular characteristics of hantaviruses (hv) epidemic in shandong province remain unclear. therefore it is useful to clarify nucl ... | 2007 | 17531126 |
| dynein-dependent transport of the hantaan virus nucleocapsid protein to the endoplasmic reticulum-golgi intermediate compartment. | in contrast to most negative-stranded rna viruses, hantaviruses and other viruses in the family bunyaviridae mature intracellularly, deriving the virion envelope from the endoplasmic reticulum (er) or golgi compartment. while it is generally accepted that old world hantaviruses assemble and bud into the golgi compartment, some studies with new world hantaviruses have raised the possibility of maturation at the plasma membrane as well. overall, the steps leading to virion assembly remain largely ... | 2007 | 17537852 |
| puumala hantavirus viremia diagnosed by real-time reverse transcriptase pcr using samples from patients with hemorrhagic fever and renal syndrome. | puumala virus (puuv) is the endemic hantavirus in northern sweden and causes nephropathia epidemica (ne), a milder form of hemorrhagic fever with renal syndrome. there is a need for fast and reliable diagnostics to differentiate the disease from other infections. by aligning virus rna sequences isolated from 11 different bank voles and one human patient, we designed a real-time reverse transcriptase (rt) pcr method for detection of puuv rna. the real-time rt-pcr assay showed linearity from 20 to ... | 2007 | 17537944 |
| hantavirus and arenavirus antibodies in persons with occupational rodent exposure. | rodents are the principal hosts of sin nombre virus, 4 other hantaviruses known to cause hantavirus pulmonary syndrome in north america, and the 3 north american arenaviruses. serum samples from 757 persons who had worked with rodents in north america and handled neotomine or sigmodontine rodents were tested for antibodies against sin nombre virus, whitewater arroyo virus, guanarito virus, and lymphocytic choriomeningitis virus. antibodies against sin nombre virus were found in 4 persons, agains ... | 2007 | 17553266 |
| radiological findings and their clinical correlations in nephropathia epidemica. | nephropathia epidemica (ne) is a mild form of hemorrhagic fever with renal syndrome (hfrs). its course varies from asymptomatic to fatal. the etiologic agent, puumala virus, belongs to the hantavirus genus of the bunyaviridae family. respiratory symptoms, from common cold to respiratory distress, occur in ne. acute renal failure (arf) is evident in over 90% of hospital-treated ne patients. in this review article, special attention is paid to radiological lung and renal involvement to investigate ... | 2007 | 17453509 |
| [hantavirus pulmonary syndrome (hps)]. | 2007 | 17491376 | |
| [the evaluation of viral load in patients with hemorrhagic fever with renal syndrome (hfrs) by real-time polymerase chain reaction]. | the system for real-time polymerase chain reaction was developed for detection of puumala virus rnaand quantitative analysis of viral rnaload in clinical samples. dynamics of viral load in blood samples from 12 patients with hfrs (from day 4 to day 17 of the disease) was studied. at day 4 viral rna load varied from 4 x 10(4) to 1 x 10(6) copies/ml. during the period of observation viral load decreased by 10 - 200 times and was not detected in majority of patients to day 11 - 15 of the disease. t ... | 2007 | 17672134 |
| seminiferous epithelium cycle of a hantavirus reservoir, the long-tailed mouse oligoryzomys flavescens (rodentia-cricetidae). | oligoryzomys flavescens, a common rodent of the temperate regions of south america, has been identified as a hantavirus reservoir. there is still little information concerning its reproductive biology, which is essential to devise effective control measurement of natural populations. this rodent is a seasonal breeder and adult males exhibit a short period of testicular regression during winter months (june-august). in the present study we provided a histological and ultrastructural analysis of t ... | 2007 | 17675200 |
| prevalence of anti-hantavirus antibodies in patients with hypertransaminemia in madrid (spain). | the hantaviruses are involved in a number of clinical syndromes of different severity and prognosis. hantaviruses are widely distributed around the world, but the spectrum of illnesses they cause outside recognized endemic areas is unclear. a retrospective analysis was performed to detect anti-hantavirus antibodies in the serum of patients with hypertransaminemia of unknown etiology and in that of healthy members of the general population of madrid (spain). antibodies were detected by indirect i ... | 2007 | 17690415 |
| puumala and tula hantaviruses in france. | the first genome sequences of tula (tulv) and puumala (puuv) hantaviruses undoubtedly originated from france were recovered from tissue samples of european common voles and bank voles captured in jura region. genetic analysis of s and m segments of french puuv strain revealed its highest similarity to strains from neighboring belgium and germany and also from slovakia. on phylogenetic trees, french puuv strain was placed within the central european lineage formed by strains from these three coun ... | 2007 | 17532080 |
| [prevalence of antibodies to hantavirus among hemodialysis patients with end-stage renal failure in kaunas and its district]. | the objective of this study was to investigate the prevalence of antibodies to hantaviruses among hemodialysis patients with end-stage renal failure in kaunas and its district. | 2007 | 17551280 |
| symptomatic human hantavirus in the americas. | 2007 | 17479912 | |
| analysis of the immune response of hantaan virus nucleocapsid protein-specific cd8+ t cells in mice. | the major histocompatibility complex (mhc) class-i restricted epitope of hantaan virus nucleocapsid protein (n) was identified using overlapping peptides and balb/c mice. using the mhc tetramer derived from the epitope, we found that the level of n-specific cd8(+) t cells increased to approximately 20% of all antigen-specific cd8(+) t cells in a mouse model of transient infection. however, n-specific cd8(+) t cells were undetectable in a mouse model of persistent infection, both in the persisten ... | 2007 | 17481691 |
| mxa-independent inhibition of hantaan virus replication induced by type i and type ii interferon in vitro. | interferons (ifn) induce an antiviral state against hantaan virus (htnv) but the mechanisms responsible for inhibition are unclear. the ifn-inducible mxa is discussed to be important for control of infections with hantaviruses. to characterize the role of endogenous mxa, the inhibition of htnv induced by type i and type ii ifns was compared in vero and a549 cells. ifnalpha and ifngamma reduced production of infectious virions, viral rna, and nucleocapsid protein with the same efficiency, althoug ... | 2007 | 17482705 |
| stable expression of hantavirus h8205 strain g1/il-2 gene and immune protection of the fusion gene. | to explore the feasibility of stable expression of hantavirus h8205 strain g1 segment and human il-2 fusion gene in vero cells, and to examine the immune protection effects on mice vaccinated with this recombinant eukaryotic expression vector containing hantavirus g1 gene and il-2 gene. with the help of lipofectamine, the vero cells were transfected with pcdna3.1/hisb-il-2-g1 and the positive cells were selected by g418. ifat and sds-page electrophoresis were used to determine the stable transfe ... | 2007 | 17497275 |
| [study of the phylogenetic relations of puumala hantaviruses, by using the mutual information calculating method]. | phylogenetic relations were investigated in the group of puumala viruses (the genus hantavirus, the family bunyaviridae) by the mutual information showing the similarity of the nucleotide sequences of s- and m-genome segments. there was evidence that recombination events might occurr in some eurasian puumala viruses (scandinavian and west-siberian genotypes). the investigation revealed the conservative sites available in the s and m segments that were common to most puumala viruses, as well as t ... | 2007 | 17500234 |
| morphological characterization of hantavirus hv114 by electron microscopy. | this study was sought to investigate the propagation and morphogenesis of a new strain of hantavirus, hv114. | 2007 | 17259735 |
| the expression and genetic immunization of chimeric fragment of hantaan virus m and s segments. | hemorrhagic fever with renal syndrome (hfrs), which is characterized by severe symptoms and high mortality, is caused by hantavirus. there are still no effective prophylactic vaccines directed to hfrs until now. in this research, we fused expressed g2 fragment of m segment and 0.7kb fragment of s segment. we expect it could be a candidate vaccine. chimeric gene g2s0.7 was first expressed in prokaryotic expression system pgex-4t. after inducing expressed fusion proteins, gst-g2s0.7 was induced an ... | 2007 | 17266922 |
| degrons at the c terminus of the pathogenic but not the nonpathogenic hantavirus g1 tail direct proteasomal degradation. | pathogenic hantaviruses cause two human diseases: hantavirus pulmonary syndrome (hps) and hemorrhagic fever with renal syndrome (hfrs). the hantavirus g1 protein contains a long, 142-amino-acid cytoplasmic tail, which in ny-1 virus (ny-1v) is ubiquitinated and proteasomally degraded (e. geimonen, i. fernandez, i. n. gavrilovskaya, and e. r. mackow, j. virol. 77: 10760-10768, 2003). here we report that the g1 cytoplasmic tails of pathogenic andes (hps) and hantaan (hfrs) viruses are also degraded ... | 2007 | 17267477 |
| seasonal variation of north american form of gigantolaelaps mattogrossensis (acari: laelapidae) on marsh rice rat in southern coastal texas. | the ectoparasites of a small mammal community within an intertidal zone in the upper gulf coast region of texas were studied to assess the seasonal variation in abundances of the mite gigantolaelaps mattogrossensis (fonseca) (acari: laelapidae) on the marsh rice rat, oryzomys palustris (harlan). further study into the ecology and dynamics of this parasite-host relationship was deemed to be necessary to expand the understanding of these potential participants in the ecology of bayou hantavirus, a ... | 2007 | 17294924 |
| cross-sectional survey on hantavirus seroprevalence in canton st. gallen, switzerland. | in 2002 the first endemic hantavirus infection in switzerland was detected only by chance following a broad spectrum of diagnostics. this raised the question, whether hantavirus infection should be included in the differential diagnosis of febrile illness of patients in switzerland. in order to estimate the frequency of hantavirus infections in switzerland, this survey on hantaviral seroprevalence was conducted in the canton st. gallen. | 2007 | 17299664 |
| emerging zoonoses and vector-borne infections affecting humans in europe. | the purpose of this study was to assess and describe the current spectrum of emerging zoonoses between 2000 and 2006 in european countries. a computerized search of the medline database from january 1966 to august 2006 for all zoonotic agents in european countries was performed using specific criteria for emergence. fifteen pathogens were identified as emerging in europe from 2000 to august 2006: rickettsiae spp., anaplasma phagocytophilum, borrelia burgdorferi, bartonella spp., francisella tula ... | 2007 | 17445320 |