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differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal hantaan virus infection.susceptibility and resistance to fatal hantaan virus meningoencephalitis were studied in immunocompetent (nu/+) and congenitally t-cell deficient (nu/nu) cd-1 mice of different ages. susceptibility of nu/+ mice to fatal infection was age-dependent, as evidenced by 100 percent mortality in mice inoculated intracerebrally with hantaan virus (strain 76-118) during the first week of life, 60 percent mortality in mice inoculated at 9 days of age, and no disease or death in mice inoculated at 14 to 42 ...19852864037
a scottish case of nephropathy due to hantaan virus infection.an illness characterised by acute renal failure, fever, conjunctivitis and a macular erythematous centrifugal rash is described in a scot who had not recently travelled abroad. there was serological evidence that the illness was due to hantaan or a closely related virus.19852863308
[detection of natural foci of hemorrhagic fever with renal syndrome on the territory of the komi assr].natural foci of hemorrhagic fever with the renal syndrome (hfrs) have been found for the first time in the komi assr. the main source of the causative agent in this territory was clethrionomys glareolus the average infection rate of which was 4.4% and in some areas as high as 22.6%. for the first time in the republic the portion of human population naturally immune to hfrs was determined, comprising 5.2% of the population. the immune structure of the population did not differ from that in other ...19852864760
serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests.antisera prepared against 16 strains of hantaviruses isolated from patients with hemorrhagic fever with renal syndrome (hfrs) or from rodents captured in hfrs-endemic and nonendemic regions were titrated against hantaan virus strain 76-118, puumala virus strain sotkamo, and prospect hill virus strain prospect hill-i by using the indirect immunofluorescent antibody and plaque reduction neutralization tests. isolates fell into one of four distinct groups or serotypes. serotype 1 included apodemus- ...19852866197
hantaan virus infection in suckling mice: virologic and pathologic correlates.the hantaan virus suckling mouse model was examined to delineate virologic and histopathologic characteristics of infection at the organ level. viral antigen and infectious virus were detected in all organs examined, with highest titers achieved in brain, lung, and kidney. a constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); ...19852865331
[characteristics of the epizootic process in hemorrhagic fever with renal syndrome].for the first time in the study of epizootology of hemorrhagic fever with the renal syndrome (hfrs) in wild animals data are presented indicating certain relationship between true infection rate of bank voles with hfrs virus and the content of the circulating antigen of hfrs virus and antibody to this virus in these animals. different age groups of animal populations were shown to have different intensity of immunity: it was more marked in animals of older age groups, and less in young animals. ...19852865854
[seroepidemiology of hemorrhagic fever with renal syndrome (hfrs) virus in fukuoka]. 19852866153
animal model of rabbits for researching epidemic hemorrhagic fever. 19862876852
pathogenesis of experimental hantaan virus infection in laboratory rats.weanling fischer rats inoculated intramuscularly with hantaan virus (strain 76-118) developed subclinical infections characterized by transient viremia and shedding of virus in saliva, persistence of virus in lung, pancreas, spleen and liver, and development of fluorescent and neutralizing antibodies in serum with immune complex deposition in lung. viremia and virus shedding in saliva occurred 10 to 13 days after inoculation. horizontal intracage transmission of infection occurred between 35 and ...19862869749
[the domestic cat as the host animal of the epidemic hemorrhagic fever virus]. 19852870786
growth experiment of hantaan virus in a549 cells: an attempt to improve the immunofluorescent antibody technique for hemorrhagic fever with renal syndrome.an assay method for the infectivity of hantaan virus, a causative agent of hfrs (hemorrhagic fever with renal syndrome), was developed by the use of ifa (immunofluorescent antibody technique). with the aid of this method, the growth characteristics of hantaan virus, 76-118 strain, were followed in a549 cells. at a maximal moi (multiplicity of infection) of 1.6 vaiu (viral antigen-inducing units) per cell, the conventionally available value, plateau level potencies of the viral antigen and virus ...19862872077
[clinical features, laboratory data and anti-viral antibody titers in a severe case of hemorrhagic fever with renal syndrome (hfrs)--a one-month course from onset]. 19862877038
[hemorrhagic fever with renal syndrome caused by puumala virus. 2 cases with hypertriglyceridemia in the aube department]. 19852866508
comparison of immunofluorescence and hemagglutination inhibition tests and enzyme-linked immunosorbent assay for detection of serum antibody in rats infected with hemorrhagic fever with renal syndrome virus.serum antibodies against the b-1 strain of hemorrhagic fever with renal syndrome (hfrs) virus in wild and experimental rats were investigated by the indirect immunofluorescent antibody (if) test, the hemagglutination inhibition (hi) test, and an enzyme-linked immunosorbent assay (elisa). in the newly developed elisa, monoclonal antibodies to the b-1 strain were applied as coating antibody. in sera from wild rats, the results obtained by the elisa agreed quite well with those obtained by the hi t ...19862877007
ecological and epidemiological data on hantavirus in bank vole populations in belgium.epidemiological and ecological data of a hantavirus infected bank vole population were collected using live-trapping methods. a close association between the distribution of hv-infected bank voles and wet habitat types was found. several seroconversions were observed during the life of individual bank voles. all seroconversions occurred within the wet habitat types and only after a certain age was reached. survival of hv-infected bank voles did not differ from not-infected animals. in the labora ...19862877647
epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in greece.epidemiological investigations were conducted following an outbreak of hemorrhagic fever with renal syndrome (hfrs) which occurred in the state of epirus, northwestern greece, in july and august 1983. a total of 8 patients were hospitalized during the outbreak; 3 were severely ill and 1 died. a serosurvey made in may 1984 sampled 184 of the approximately 400 residents of the village of tsepelovo, where 4 patients resided, and found 12 (6.5%) persons, including convalescent sera from 4 patients, ...19862871769
epidemiological studies of hemorrhagic fever with renal syndrome (hfrs) related virus infection among urban rats in hokkaido, japan.seroepidemiological studies of hemorrhagic fever with renal syndrome (hfrs) virus infection were carried out among urban rats (rattus norvegicus and rattus rattus) and small field rodents in hokkaido, japan. an urban rat colony that was seropositive to sr-11 strain of hfrs virus (laboratory rat origin) was demonstrated in february 1983 at a dumping ground area of kami-iso town near hakodate port. an hfrs-related virus, named ki-262 strain, was isolated from the lung tissue of a seropositive rat ...19862871823
ribavirin therapy for hantaan virus infection in suckling mice.we recently reported that ribavirin inhibited hantaan virus (hv) replication in vitro. in the present study, we used the hv suckling mouse model to evaluate the efficacy of treatment with various doses of ribavirin. beginning on day 10, untreated animals, infected with ten times the amount of hv (strain 76/118) required to kill 50% of the animals, lost weight; by days 15 to 18, they developed paralysis of both hind limbs, and they died between days 20 and 21. treatment with 50 mg of ribavirin/kg ...19862869089
hantavirus nephropathy in western europe: ubiquity of hemorrhagic fevers with renal syndrome. 19862869650
detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and korean hemorrhagic fever by using puumala virus cell culture antigen. 19862871114
infection of laboratory workers with hantavirus acquired from immunocytomas propagated in laboratory rats.hantavirus has been isolated in cell culture from rat immunocytomas used and stored at a research laboratory in the u.k. where there was evidence of a laboratory-acquired infection leading to haemorrhagic fever with renal syndrome. both transplantation into lou/m/wsl rats and storage of passaged immunocytomas at -70 degrees c over a period of 8-10 years had not eliminated the virus. the isolates were identified as hantavirus by means of serum obtained from patients with hantavirus infection as w ...19862871112
the antigenic analysis of haemorrhagic fever with renal syndrome viruses in china by monoclonal antibodies.thirty-six strains of haemorrhagic fever with renal syndrome (hfrs) virus were isolated from patients and a number of host animals in various areas in china. they were analysed by an immunofluorescence test (ifat) using 10 monoclonal antibodies (mcabs) specific for the hfrs virus; antigenic differences among the strains have been demonstrated. the hfrs virus strains revealed nine different reactions with the mcabs, showing that there are at least nine different antigenic determinants including g ...19862878042
[hemorrhagic fever with a renal syndrome]. 19862882632
[epidemiologic study of epidemic hemorrhagic fever in guangzhou]. 19862872966
[hemorrhagic fever with renal syndrome among human populations of tiantai county]. 19862872967
haemagglutination-inhibition test for haemorrhagic fever with renal syndrome using virus antigen prepared from infected tissue culture fluid.haemagglutinating (ha) antigens of four strains of virus related to that causing haemorrhagic fever with renal syndrome (hfrs) were prepared from infected tissue culture fluids by ultracentrifugation. the titres of the precipitated antigens were increased considerably by acetone extraction and sonication. acetone extraction completely inactivated infectious virus in the antigen preparations. the antigens were ph-dependent, with ph optima at 5.8. good correlations were observed in human and rat s ...19862868067
efficacy, toxicology and clinical applications of ribavirin against virulent rna viral infections. 19852867737
[results of a humoral immunity study in hemorrhagic fever with renal syndrome in the maritime territory].the paper presents the results of serological diagnosis of hemorrhagic fever with renal syndrome (hfrs) and studies of the time course of humoral immunity formation in this disease carried out in 1980-1983 in the maritime territory, one of the active hfrs foci.19862873687
[hemorrhagic fever with renal syndrome in madagascar. first seroepidemiologic survey of rat populations]. 19862879517
serological survey with the antigen of haemorrhagic fever virus with renal syndrome in small rodents in slovakia.results of serological survey in small rodents with the antigen of haemorrhagic fever with renal syndrome (hfrs) virus indicate the existence of a natural focus of this virus in slovakia. antibodies were found in the following free-living rodent species: clethrionomys glareolus, apodemus agrarius, apodemus sylvaticus, pitymys subterraneus, microtus arvalis and microtus economus. a total 10 out of 120 (8.2%) small rodents trapped in investigated localities of western and eastern slovakia had anti ...19862873734
persistent infection of rats with haemorrhagic fever with renal syndrome virus and their antibody responses.newborn (within 24 h after birth), 1-week-old and 6-week-old (adult) rats were inoculated with a hantaan-related virus (b-1) and attempts were made to isolate the virus from various organs. virus-specific antigens were detected in various organs of newborn rats. moreover virus could be isolated from almost all their organs even 25 weeks after infection. in contrast, in rats infected at 6 weeks of age the virus could be isolated from various organs but its concentration decreased progressively wi ...19862878971
[experimental study on natural infection, biting and transovarial transmission of epidemic haemorrhagic fever virus in gamasid mites]. 19862878731
[hemorrhagic fever with the renal syndrome]. 19872887068
acute hantavirus nephropathy in belgium: preliminary results of a sero-epidemiological study. 19872887093
[serological data on hemorrhagic fever with renal syndrome in southeast asia].using an indirect immunofluorescent test with hantaan 76-118 and puumala strains as antigens, antibodies against haemorrhagic fever with renal syndrome viruses were found for the first time in human in laos and viet-nam and confirmed the previously published results in thailand. these results suggest the existence of an hantaan-related virus in these countries.19862879646
[electron microscopic study of the morphology of virus of hemorrhagic fever with renal syndrome in suckling mice]. 19862875562
some biological properties of virus strains isolated from hemorrhagic fever patients with renal syndrome. 19862879712
epidemiology of nephropathia epidemica in sweden.a comprehensive study of nephropathia epidemica (ne), caused by puumala virus, was conducted in sweden. human sera from residents of various regions of sweden were examined for antibody to puumala virus, and the incidence of ne was determined. small mammals were captured at locations throughout sweden and were examined for antibody to puumala virus and for antigen. the human serosurvey found the highest prevalence rates and the highest incidence rates in northern sweden. the bank vole was found ...19872879874
[sero-types in the hemorrhagic fever renal syndrome: i. an identification of sero-types of hfrs by hemagglutination inhibition assay]. 19862874886
occurrence and distribution of hantavirus in wild living mammals in belgium.small mammals were screened for the presence of antibodies to hantaan virus (htn) and hantavirus (hv) antigen in belgium. antibody and antigen-positive animals were found in different parts of the country. one insectivore and five rodent species were found positive. the highest prevalence of infection was found in the bank vole (clethrionomys glareolus). a relation between infected animals and wet habitats was observed. it was obvious that in bank vole the likelihood of infection increased with ...19872883857
[antibody formation dynamics in patients from the far east with hemorrhagic fever with renal syndrome]. 19862876551
[study on the spread of hemorrhagic fever with renal syndrome among animal hosts]. 19872887291
[immuno-histochemical study of experimental epidemic hemorrhagic fever]. 19862886229
[combined extracorporeal detoxification of the blood and lymphatic drainage in hemorrhagic fever with renal syndrome]. 19872883340
partial characterization of a hantavirus isolated from a clethrionomys glareolus captured in belgium.a hantavirus was isolated in vero-e6 cells from lungs of a free living bank vole (clethrionomys glareolus) captured in turnhout, province of antwerp--northern part of belgium. with help of monoclonal antibodies the belgian hantavirus isolate could be clearly differentiated from hantaan virus strain 76-118, prospect hill virus strain ph1 and sr11, a hantavirus isolated from laboratory wistar rat in japan, but not from the nephropathia epidemica virus strain hällnäs.19872886029
[acute interstitial nephritis]. 19872885911
early diagnosis of hemorrhagic fever with renal syndrome by igm elisa technique. 19872888601
detection of hantaviruses with rna probes generated from recombinant dna.radiolabeled rna probes generated from cdna clones of the m and s genome segments of hantaan virus readily detected hantaan virus and two isolates from korean hemorrhagic fever patients but were less effective in detecting four other hantaviruses.19872886113
hantavirus disease. 19872892467
detection of specific serum immunoglobulin m in nephropathia epidemica (scandinavian epidemic nephropathy) by a biotin-avidin-amplified immunofluorescence method.a biotin-avidin-amplified indirect immunofluorescence method was used to demonstrate specific serum immunoglobulin m (igm) antibodies in nephropathia epidemica, the scandinavian type of hemorrhagic fever with renal syndrome. the antigen in the test was the cross-reacting agent of korean hemorrhagic fever, hantaan virus. sixty-two serum samples from 15 patients with clinically typical nephropathia epidemica were analyzed. eleven patients had specific igm in one or more serum samples. the igm coul ...19872885340
[advances in the diagnosis of epidemic hemorrhagic fever]. 19872892653
role of t lymphocyte subsets in protection and recovery from hantaan virus infection in mice.adult athymic nude (balb/c background) mice or inbred balb/c mice were inoculated intraperitoneally with hantaan virus (hv), and attempts were made to isolate the virus from brain, lung and spleen. virus was isolated from the organs of balb/c mice for only a short time after infection but was isolated from various organs of nude mice consistently for at least 84 days after infection. viral antigen was also detected in various organs of nude mice for a long time after infection. the effects of ad ...19872885394
[the first isolation of the hfrs virus from the lung of rattus norvegicus and the blood of patients in jinzhou prefecture]. 19872888536
clinical and epidemiological aspects of hemorrhagic fever with renal syndrome (hfrs) in greece.twenty-three cases of hemorrhagic fever with renal syndrome were serologically diagnosed in rural populations of greece between 1982 and 1985. the clinical picture of the disease was severe, (3 deaths recorded among 23 cases) and more closely resembled korean hemorrhagic fever than nephropathia epidemica. examination of patients' sera by indirect immunofluorescence (ifa) assays and plaque reduction neutralization (prnt) tests using hantaan 76-118, puumala, and seoul (urban rat-associated hantaan ...19872888688
cats--source of protection or infection? a case-control study of hemorrhagic fever with renal syndrome.in the first case-control study analyzing risk factors in sporadic hemorrhagic fever with renal syndrome, 111 cases occurring in shanghai in 1983 and 1984 and 136 matched controls were studied. three factors were associated with risk of disease: travel in the month before onset of illness, intense exposure to rodents in the home, and cat ownership. risk associated with cat ownership was not confounded by exposure to rodents in the home. neither cat ownership nor risk associated with rodent expos ...19872889355
bluetongue and epizootic hemorrhagic disease in white-tailed deer from oklahoma: serologic evaluation and virus isolation.blood samples were collected from 194 white-tailed deer from 27 locations in oklahoma from 1977 through 1984. sixty-eight (35%) of the deer had antibody against bluetongue virus (btv) and 78 (40%) had antibody against epizootic hemorrhagic disease virus. seropositive deer were detected in each of the 4 geographic quadrants of the state. virus isolation was attempted in 40 deer from the northeast quadrant of oklahoma (1983 through 1984); btv was isolated from 11 deer, but epizootic hemorrhagic di ...19872888426
[detection of viral antigens in various organs in 14 fatal cases of epidemic hemorrhagic fever]. 19872892652
hemorrhagic fever with renal syndrome: mode of transmission to humans.hemorrhagic fever with renal syndrome (hfrs) is a viral disease spread to humans from persistently infected rodents and other small mammals. the consensus of opinion regarding the mechanism of transmission to man indicates a principal role for respiratory infection from aerosols of infectious virus from rodent urine, feces and saliva. interhuman, secondary spread of infection does not occur. the role of ectoparasites in virus transmission is undefined. however, epidemiologic considerations and v ...19872889846
control of laboratory acquired hemorrhagic fever with renal syndrome (hfrs) in japan.by the end of 1985, 126 human cases of laboratory acquired hemorrhagic fever with renal syndrome (hfrs) were recorded in japan. seroepidemiological studies revealed that laboratory rats exhibited high ifa titers against hantaan or related viruses at locations where hfrs patients occurred. laboratory researchers contracted hfrs more frequently than laboratory animal technicians or caretakers, although a laboratory animal caretaker died of the disease. inhalation of hfrs-virus contaminated air in ...19872889847
antibody to hemorrhagic fever with renal syndrome viruses (hantaviruses) in the united states.hantaviruses similar to those which cause hemorrhagic fever with renal syndrome have been isolated from rodents in the united states. serologic evidence suggests that these viruses infect humans. clinical disease has not, however, been associated with infection in the united states. to expand knowledge of the distribution of hantaviruses in the united states and attempt to identify a clinical syndrome associated with infection, a serologic survey was undertaken of us forestry service personnel a ...19872891295
prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of baltimore, maryland.we used a prospective seroepidemiological study, in conjunction with a mark-release-recapture protocol, to investigate the transmission of hantaviruses in four rodent species from baltimore, maryland, from june 1984 to june 1986. a total of 1,208 captures of 762 rodents provided 984 individual blood samples. the antibody prevalence, as determined by frequency of reciprocal indirect fluorescent antibody (ifa) titers greater than or equal to 32, was 33.9% in rats (rattus norvegicus, n = 466), 28.3 ...19872891308
[detection of foci of hemorrhagic fever with renal syndrome in the estonian ssr].examination by the enzyme-immunoassay of organs of 10 small mammal species trapped in different landscape zones of the estonian ssr revealed the presence of hfrs virus antigen in organs of bank voles and field mice. radioimmunoassay studies of serum specimens from donors demonstrated the presence of antibody to hfrs virus in 2.54% of those examined.19872891222
[an epidemiologic study on hfrs after six years surveillance--comparison with antibodies for two virus strain, hantaan virus 76-118 strain and wkm strain in members of college]. 19872890697
isolation of a hantavirus from a severely ill patient with hemorrhagic fever with renal syndrome in greece. 19872890690
hantavirus nephropathy, an unrecognized cause of transient acute renal failure in belgium. 19872892329
[hantavirus nephropathy in belgium: description of 2 new cases originating in southern provinces]. 19872892330
[hantavirus nephropathy: apropos of 4 cases diagnosed in south hainaut]. 19872892331
zoonotic implications of hantaan-like viruses: an introduction. 19872889843
epidemiology of hantaan and related viruses.hantaan and related viruses, the causative agents of hemorrhagic fever with renal syndrome (hfrs), are significant human pathogens. current epidemiologic evidence indicates that these pathogens are disturbed more widely than once believed, and they are likely to cause disease when man comes into close contact with infected rodents. this report summarizes the characteristics of the hantaanp-related viruses of the genus hantavirus including epidemiology, ecological characteristics, routes of trans ...19872889844
[hemorrhagic fevers with renal syndrome caused by hantaan virus in france]. 19872892243
haemorrhagic fever with renal syndrome involving the liver.a case of haemorrhagic fever with renal syndrome that originated in malaysia is reported. the patient presented with clinical symptoms which were not typical of the disease as seen in endemic regions. renal involvement, which is characteristic of haemorrhagic fever with renal syndrome, was mild, and the predominant symptom was a persistently marked elevation of serum transaminase levels that was suggestive of hepatitis. liver involvement has not been described in the asian form of haemorrhagic f ...19872890086
nephropathia epidemica: incidence of clinical cases and antibody prevalence in an endemic area of sweden.the incidence of nephropathia epidemica (ne) was compared with the ne antibody prevalence in normal population in a highly endemic area of sweden (västerbotten county). the antibody prevalence rate in the oldest age groups were found to be 14 and 20 times higher than the accumulated life-risk of being hospitalized with ne for men and women respectively. whether the infection in persons not admitted to hospital is subclinical, atypical or clinically fulminant, remains to be determined.19872890534
[detection of natural foci of the hemorrhagic fever with renal syndrome in the georgian ssr].the circulation of the causative agent of hemorrhagic fever with renal syndrome (hfrs) in georgia was studied. altogether, 7,938 small mammals of 16 species trapped in 23 administrative areas of the republic were examined, and the specific antigen of hfrs virus was detected in 308 (3.8%). in serological examinations of 10 patients, antibody to hfrs virus was found in 4. analysis of the above results indicates the existence of natural foci of hfrs in the georgian ssr.19872893492
[exact determination of the eastern border of the european portion of the nosogeographic range of the hemorrhagic fever with renal syndrome].radioimmunoassay was used for examinations of 21,488 serum specimens from the population of 145 areas of 8 regions and 2 republics. the immune portion comprised 8.8% to the west of the assumed border and 2.7% to the east (t = 20.7). active natural foci of the infection were found in individual territories located to the east of the assumed border (areas of saratov province to the north of the irgiz river, trans-ural areas of bashkiria, southern taiga areas of sverdlovsk, tyumen, and northwestern ...19872893493
[an epidemiologic study on rats associated with outbreak of hemorrhagic fever with renal syndrome--comparison with antibodies for two virus strain, hantaan virus 76-118 strain and newly isolated wkm strain]. 19872890696
enzyme-linked immunosorbent assay for detection of antibody against hemorrhagic fever with renal syndrome virus in sera from experimentally infected rats. 19872892958
baculovirus expression of the small genome segment of hantaan virus and potential use of the expressed nucleocapsid protein as a diagnostic antigen.autographa californica nuclear polyhedrosis virus (acnpv) was used as an expression vector for the nucleocapsid protein gene of hantaan virus. two different cdna clones representing the small genome segment of hantaan virus were inserted into the transfer vector pacym1, and recombinants were generated by replacement of a portion of the baculovirus polyhedrin gene with the foreign, hantaan virus gene. recombinants containing both the first and second atg initiation codons of the hantaan virus gen ...19882895799
[immune-mediated renal damage in epidemic hemorrhagic fever with renal syndrome (hantavirus nephropathy]. 19882898325
[transmission of epidemic hemorrhagic fever virus between mice and mites in ehf endemic areas]. 19872898326
[spreading of the virus of hemorrhagic fever with renal syndrome among small mammals of a meadow-field complex and its epidemiological significance]. 19882901027
hemorrhagic fever with renal syndrome (nephropathia epidemica) in norway: seroepidemiology 1981-1985.an indirect fluorescent antibody technique (ifat) was applied to serologically confirm the clinical diagnosis in 507 nephropathia epidemica (ne) suspected patients. hantaan virus (hv), the agent of korean hemorrhagic fever, which is serologically related to the ne agent, was used as antigen. both igg and igm reactions were detected. high levels of igg antibodies to hv were common, even in the acute phase of illness. over a 5-year period, a total of 35% of the ne suspected patients revealed antib ...19882900551
[incidence and clinical forms of hemorrhagic fever with renal syndrome in eastern slovakia]. 19882899460
hemorrhagic fever with renal syndrome in yugoslavia: detection of hantaviral antigen and antibody in wild rodents and serological diagnosis of human disease.lung tissues from 547 rodents and 26 insectivores captured between 1981 and 1984 in central bosnia (fojnica) and central serbia (cacak), 2 regions known to be endemic for hemorrhagic fever with renal syndrome (hfrs), were examined for hantaviral antigen by the indirect immunofluorescent antibody technique. antigen was detected in 17/231 apodemus flavicollis, 3/187 a. sylvaticus, 1/46 a. agrarius, 4/32 mus musculus, and 3/28 clethrionomys glareolus. in addition, antibodies against hantaan and puu ...19882900550
first human case of haemorrhagic fever with renal syndrome in the central african republic. 19872895515
[detection of natural foci of hemorrhagic fever with renal syndrome in the territory of crimean and chernigov provinces]. 19872895547
incidence and geographic distribution of serologically verified cases of nephropathia epidemica in sweden.a nationwide survey of hospitalized, serologically verified adult nephropathia epidemica cases in sweden from 1978 to 1981 was performed. serum was collected from 1,063 patients with a diagnosis of nephropathia epidemica or one of 10 other renal diseases with related symptoms. sera were analyzed by indirect immunofluorescence technique for the presence of immunoglobulin g antibodies to hantaan virus, causative agent of korean hemorrhagic fever that cross-reacts with the nephropathia epidemica ag ...19882895579
haemorrhagic fever with renal syndrome: clinical, virological and epidemiological perspectives.haemorrhagic fever with renal syndrome (hfrs) is caused by a group of rna viruses within the family of bunyaviridae known as hantaviruses. the classical, severe form of hfrs is characterized by fever, headache, abdominal and lumbar pain, proteinuria, haemorrhagic phenomena, shock and renal failure. the disease is associated with the prototype hantaan virus and occurs in rural areas of korea and china with apodemus mice as reservoir hosts. a clinically less severe form of hfrs, which is caused by ...19872895603
serologic differentiation of virus strains of hemorrhagic fever with renal syndrome (hfrs) by monoclonal antibodies. 19872895468
serological survey of prospect hill virus infection in indigenous wild rodents in the usa.we found serological evidence of infection with prospect hill virus, a hantaan-like virus isolated from meadow voles (microtus pennsylvanicus), in microtine and cricetid rodents trapped in maryland, west virginia, minnesota and california, usa. fluorescent antibodies were detected in sera from m. pennsylvanicus (74/277), m. californicus (39/185), clethrionomys gapperi (5/51), peromyscus maniculatus (4/22) and p. truei (1/11). sera from seropositive p. maniculatus contained neutralizing antibodie ...19872895510
[experimental study on bitting, trans-stadial and transovarian transmission of epidemic haemorrhagic fever virus by gamasid mites ornithonyssus bacoti]. 19872894898
[the study on inapparent infection in the endemic areas of the wild and domestic rat types ehf in parts of north-east areas in china]. 19882898296
[a study on the early diagnosis of epidemic hemorrhagic fever by elisa for examining antigens in urine]. 19882898297
dual infection with leptospira and hantavirus. 19882898071
haemorrhagic fever with renal syndrome: a disease of world-wide distribution. 19882898253
[hantaan virus infections as a cause of acute kidney failure. 3 cases in west germany].three cases of hantaan virus infection (korean haemorrhagic fever) leading to acute renal failure are described. all three had mild haemorrhagic fever with a renal syndrome. it had started with acute fever followed by oliguria, proteinuria and microhaematuria (in two patients) in the further course of the disease, as well as urea and creatinine retention. one patient needed to be dialysed twice. hantaan virus-specific igg antibodies were demonstrated in all three patients; one also had igm antib ...19882897900
conservation of antigenic properties and sequences encoding the envelope proteins of prototype hantaan virus and two virus isolates from korean haemorrhagic fever patients.viruses isolated from the blood of two korean haemorrhagic fever patients were propagated in cell culture and compared to prototype hantaan virus which was isolated from apodemus mice. the antigenic properties of the human isolates were found to be closely related to hantaan virus by plaque reduction neutralization, haemagglutination inhibition and fluorescent antibody staining with both polyclonal and monoclonal antibodies. the medium genome segment of each human isolate was sequenced and compa ...19882900289
hantavirus and leptospira. 19882900396
detection of the antigen and antibodies to the eastern subtype of haemorrhagic fever with renal syndrome virus in small rodents in slovakia.direct enzyme-linked immunosorbent assay (elisa) was used for the demonstration of haemorrhagic fever with renal syndrome (hfrs) virus antigen in lung tissue of small rodents trapped in eastern and western slovakia. the eastern subtype of hfrs virus antigen was demonstrated in the lungs of apodemus agrarius and of the western subtype in the lungs of microtus arvalis. antibodies to hfrs virus antigen have been detected in apodemus species (a. agrarius and a. flavicollis) in higher titres to the e ...19882899965
antigenic relationship between hantaviruses analysed by immunoprecipitation.antigenic relationships between seven hantaviruses isolated in sweden, belgium, korea, european u.s.s.r. and asian u.s.s.r. were studied by radioimmunoprecipitation assays (ripa) and indirect immunofluorescence tests (ift). animal immune sera and haemorrhagic fever with renal syndrome (hfrs) patient sera from the above countries were used. the strains fell into three antigenic groups by both ripa and ift: nephropathia epidemica (ne)-type, korean haemorrhagic fever (khf)-type and urban rat-type. ...19882902191
hantavirus infection: a new imported viral haemorrhagic fever. 19882896755
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