Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| analysis of the immune response to hantaan virus nucleocapsid protein c-terminal-specific cd8(+) t cells in patients with hemorrhagic fever with renal syndrome. | hantaan virus (htnv), the prototype member of the hantavirus genus in the family bunyaviridae, causes hemorrhagic fever with renal syndrome (hfrs), which is characterized by capillary leakage, hemorrhage, and renal injury, and is an important public health problem in china. some kinds of immune cells, particularly cd8(+) t cells, are involved in the pathogenesis of hantavirus infection. the nucleocapsid protein (np) of the hantavirus is the most conserved structural protein and the most abundant ... | 2009 | 19594396 |
| hantaviruses and climate change. | most hantaviruses are rodent-borne emerging viruses. they cause two significant human diseases, haemorrhagic fever with renal syndrome in asia and europe, and hantavirus cardiopulmonary syndrome in the americas. very recently, several novel hantaviruses with unknown pathogenic potential have been identified in africa and in a variety of insectivores (shrews and a mole). because there is very limited information available on the possible impact of climate change on all of these highly dangerous p ... | 2009 | 19604276 |
| [from mice to men: the threat of hantavirus infections]. | hantaviruses are naturally hosted by small mammals. virus transmission to humans can result in the development of hemorrhagic fever with renal syndrome (asia, europe) or hantavirus cardiopulmonary syndrome (the americas). certain hantaviruses can cause life-treatening infections with case fatality indices up to about 50%. different virus types have evolved which use different species of small mammals (mainly but not exclusively rodent species) as natural reservoirs. it is still unknown why these ... | 2009 | 19999378 |
| increased host species diversity and decreased prevalence of sin nombre virus. | emerging outbreaks of zoonotic diseases are affecting humans at an alarming rate. until the ecological factors associated with zoonoses are better understood, disease emergence will continue. for lyme disease, disease suppression has been demonstrated by a dilution effect, whereby increasing species diversity decreases disease prevalence in host populations. to test the dilution effect in another disease, we examined 17 ecological variables associated with prevalence of the directly transmitted ... | 2009 | 19624913 |
| a habitat-based model for the spread of hantavirus between reservoir and spillover species. | new habitat-based models for spread of hantavirus are developed which account for interspecies interaction. existing habitat-based models do not consider interspecies pathogen transmission, a primary route for emergence of new infectious diseases and reservoirs in wildlife and man. the modeling of interspecies transmission has the potential to provide more accurate predictions of disease persistence and emergence dynamics. the new models are motivated by our recent work on hantavirus in rodent c ... | 2009 | 19616014 |
| [the first french hemorrhagic fever with renal syndrome in pregnant woman]. | the seroprevalence of hantavirus in france is very low. the hantavirus is the causative agent of hemorrhagic fever with renal syndrome (hfrs). in 2005, we report the first french hfrs case in a pregnant woman presenting with influenza like symptoms in an endemic area associated with suggestive biologic abnormalities. she was delivered by emergency cesarean section. her child had a neonatal respiratory distress, thrombocytopenia and elevated liver enzymes levels, which suggest a transplacental ha ... | 2009 | 19497685 |
| identification of oligopeptides mimicking the receptor-binding domain of hantaan virus envelope glycoprotein from a phage-displayed peptide library. | attachment of enveloped viruses to cells is triggered by the receptor-binding domain (rbd) on envelope glycoproteins (gp) binding to receptors located on the cell surface. to date, recognized receptors and rbd of hantaan virus (htnv) have not been exactly defined. in this study, one monoclonal antibody (mab) 3g1 possessing high neutralizing activity, which is directed against htnv envelope glycoprotein g2, was used to determine the crucial motif of rbd. peptide ligands binding to mab 3g1 were se ... | 2009 | 19767836 |
| production and characterization of monoclonal antibodies against the recombinant nucleoprotein of araucaria hantavirus. | hantaviruses are rodent-borne rna viruses that cause hemorrhagic fever with renal syndrome (hfrs) or hantavirus pulmonary syndrome (hps). from the first detection of infection in brazil in 1993 until 2009, 1161 cases of hps have been reported, with mortality rates of around approximately 40%. currently, due to the absence of a vaccine or specific antiviral therapy, the only way to reduce mortality by hantavirus infection is a fast and precise diagnosis that allows for supportive clinical health ... | 2009 | 19654026 |
| [geographic expansion of hantavirus pulmonary syndrome in argentina. the southernest case report]. | since 1995 more than 1000 cases of hantavirus pulmonary syndrome (hps) were reported in argentina, a severe disease and often fatal to humans. most cases were associated with andes virus (and) that caused few events of person-to-person transmission. several lineages of pathogenic and viruses have been described, including and south, hosted by the rodent oligoryzomys longicaudatus which affects the patagonian region of argentina and chile. we studied the clinical and epidemiological characteristi ... | 2009 | 20053606 |
| degradation and aggresome formation of the gn tail of the apathogenic tula hantavirus. | the cytoplasmic tails of envelope glycoprotein gn of pathogenic hantaviruses but not of the apathogenic prospect hill virus (phv) were recently reported to be proteasomally degraded in simian cos7 cells. here, we show that the cytoplasmic tails of the glycoproteins of the apathogenic hantaviruses tula virus (tulv) and phv are also degraded through the ubiquitin-proteasome pathway, both in human hek-293 and in simian vero e6 cells. tulv gn tails formed aggresomes in cells with proteasomal inhibit ... | 2009 | 19675185 |
| hantavirus regulation of endothelial cell functions. | hantaviruses cause two vascular permeability-based diseases and primarily infect endothelial cells which form the primary fluid barrier of the vasculature. since hantavirus infections are not lytic, the mechanisms by which hantaviruses cause haemorrhagic fever with renal syndrome (hfrs) or hantavirus pulmonary syndrome (hps) are indeterminate. hps is associated with acute pulmonary oedema and hfrs with moderate haemorrhage and renal sequelae, perhaps reflecting the location of vast microvascular ... | 2009 | 19967132 |
| [thrombocytopenia and acute kidney injury]. | a 31-year old man is addressed to the emergency department for fever, abdominal pain and vomiting. laboratory tests reveal an inflammatory syndrome, thrombocytopenia, acute kidney injury associated with major proteinuria (more than 3 g/24 h). evaluation will conclude to an acute interstitial nephritis and the serology is positive for hantavirus. this clinical case illustrates differential diagnosis of acute renal failure and reminds the theory of hemorrhagic fever with renal syndrome : usual cli ... | 2009 | 19998799 |
| the occurrence of hemorrhagic fever with renal syndrome in southern parts of bosnia and herzegovina. | bosnia and herzegovina (b&h) has been known as an endemic region for hemorrhagic fever with renal syndrome (hfrs) for over 50 years. multiple epidemics of this disease have been registered so far, especially in endemic parts of central and northeastern bosnia, as well as the sarajevo region. seroepidemiological investigations demonstrate naturalization of hantaviruses and their wide spread in b&h. however, there are no studies from the southern areas of b&h, and endemic foci of this disease are ... | 2009 | 20120399 |
| perspectives on scrub typhus, tick-borne pathogens, and hantavirus in the republic of korea. | 2009 | 20088033 | |
| crossing borders in health communication research: toward an ecological understanding of context, complexity, and consequences in community-based health education in the u.s.-mexico borderlands. | in the past 15 years, researchers in health information dissemination have made significant strides in addressing context, complexity, and consequences (sharf's "3 cs") in theory, research, and praxis. the goal of integrating the 3 cs in this field, however, remains a challenge. in this article, the authors present 6 principles of a postmodern ecological approach to health information dissemination that attempts such integration. the authors outline proposed principles and use a multiyear, inter ... | 2009 | 20183369 |
| [construction of a recombinant adenovirus carrying the hantaan virus glycoprotein g2 gene and its expression in hela cells]. | we constructed the recombinant adenovirus expressing the glycoprotein g2 of hantaan virus. firstly we obtained coding gene fragment of g2 by pcr, and subsequently inserted the gene of interest into the adenoviral pshuttle vector pad5-cmv. then we co-transfected the recombinant pshuttle vector and adenovirus skeleton plasmid into hek293 cells by calcium phosphate precipitation method. after the recombinant adenovirus were packaged and amplified in hek293 cells, we observed the expression of repor ... | 2009 | 20112705 |
| [rare case of crimean haemorrhagic fever in a pregnant woman]. | a rare case of crimean haemorrhagic fever in a pregnant woman during the sixth month of gestation is described. the typical clinical course of the disease is present with positive anamnesis and visible locus from tick bite. after several days, fever and local lymphadenitis appear, followed by severe toxicoinfectious and haemorrhagic syndromes. the disease is proved virologically and serologically. the outcome is favourable for the pregnant woman. she is discharged home after 16-day hospital trea ... | 2009 | 20198776 |
| an experimental test of factors attracting deer mice into buildings. | deer mice (peromyscus maniculatus) are the principal reservoir host of sin nombre virus (snv). deer mice use a wide variety of habitats including peridomestic settings in and around human dwellings, their presence in and around homes has been implicated as a risk factor for acquiring hantavirus pulmonary syndrome. deer mice are believed to enter buildings in order to gain access to a variety of resources including food, bedding material, and better thermal microclimates. however, no one has expe ... | 2009 | 20628475 |
| young man with kidney failure and hemorrhagic interstitial nephritis. | 2009 | 19556044 | |
| hantavirus infection and habitat associations among rodent populations in agroecosystems of panama: implications for human disease risk. | hantavirus cardiopulmonary syndrome (hcps), which is caused by infection with choclo virus, is uncommon in panama, yet seropositivity among rural residents is as high as 60%. to clarify the environmental risk factors favoring rodent-to-human transmission, we tested serum from 3,067 rodents captured over a five-year period for antibodies against recombinant n protein of hantavirus by enzyme immunoassay and strip immunoblot. among 220 seropositive rodents, oligoryzomys fulvescens, the reservoir of ... | 2009 | 19556568 |
| platelet glycoprotein iib/iiia (hpa-1 and hpa-3) polymorphisms in patients with hemorrhagic fever with renal syndrome. | this study investigated the relationship between human platelet alloantigen (hpa) polymorphisms of glycoprotein iib/iiia and hemorrhagic fever with renal syndrome (hfrs). hpa-1 and hpa-3 genotyping was performed with allele-specific primer polymerase chain reaction in 104 patients with hfrs and 100 normal individuals as controls. the relationships between gene polymorphisms of hpas and hfrs and the disease severity were analyzed. the results indicated no significant difference in hpa-1 genotype ... | 2009 | 19286442 |
| [cloning and expression of the nucleoprotein gene of puumala-like virus]. | in order to detect hokkaido virus (hokv), a recombinant baculovirus containing the nucleoprotein (np) gene of hokv was constructed, and then the np was expressed in insect cell. | 2009 | 19565881 |
| [study on the difference of genes and the type identification of hantavirus from lishui, zhejiang province]. | to isolate hantavirus from lishui county--one of the epidemic regions for hemorrhagic fever with renal syndrome (hfrs), in zhejiang province, and to identify the serotype and molecular/biological characteristics of a new htn subtype hantavirus (hv) strains, hopefully to provide evidence for hfrs prevention and therapy. | 2009 | 19565882 |
| a novel cardiotropic murine adenovirus representing a distinct species of mastadenoviruses. | during cell culture isolation experiments to recover dobrava hantavirus from a suspension of liver from a striped field mouse (apodemus agrarius), an unknown virus was coisolated. atypically for hantaviruses, it had extensive cytopathic effects. using a random pcr approach, it was identified as a novel murine adenovirus, madv-3 (for madv type 3). a plaque-purified virus clone was prepared and further characterized. the complete genome sequence of madv-3 was determined to be 30,570 bp in length. ... | 2009 | 19297486 |
| the first established focus of hantavirus infection in poland, 2007. | the first hantavirus infection outbreak in poland (with different seroetiology) was identified between august-december 2007. thirteen cases were reported in southeast poland: 12 cases in the carpathians bordering with northeast slovakia, mainly in the forested areas of the bieszczady mountains, and one case approximately 100-120 kilometres north from the others, in the adjacent sub-carpathian region. four additional cases of past infection were identified retrospectively, based on the presence o ... | 2009 | 19572481 |
| bunyavirus n: eif4f surrogate and cap-guardian. | hantaviruses comprise a genus of the bunyavirus family of viruses. viruses of this family, along with the arenaviruses, and the orthomyxoviruses, including influenza, contain a negative sense, segmented rna genome. viral nucleocapsid proteins play a well-established role in the formation of intracellular and virion-associated nucleocapsids that harbor and shield viral genomic rna. however, recent observations indicate that hantavirus nucleocapsid protein (n) has additional unexpected biological ... | 2009 | 19342890 |
| predicting the risk of hantavirus infection in beijing, people's republic of china. | to understand the spatial distribution of hantavirus infections across landscapes and its influencing environment factors in beijing, people's republic of china, rodents captured in this region were examined for hantavirus by reverse transcription-polymerase chain reaction. a total of 1,639 rodents were trapped at 86 randomly selected sites. the overall infection rate for hantavirus was 7.14% in the rodents. multivariate logistic regression analysis indicated that the natural infection rates for ... | 2009 | 19346399 |
| [purpura fulminans, cerebral infarcts and multiorganic dysfunction due to hantavirus infection. review and case report]. | multiorganic failure is a rare manifestation of hantavirus infection but it should be included among differential diagnoses of multiorganic failure in the pediatric age. currently, there is no effective therapy for this infection. a high suspicion index and early referral to a pediatric intensive care unit with extracorporeal membrane oxygenation may lead to a favourable impact in the outcome. we report a fatal case of hantavirus infection in a 9-year-old girl with a severe disease refractory to ... | 2009 | 19350147 |
| analysis of puumala hantavirus in a bank vole population in northern finland: evidence for co-circulation of two genetic lineages and frequent reassortment between strains. | in this study, for the first time, two distinct genetic lineages of puumala virus (puuv) were found within a small sampling area and within a single host genetic lineage (ural mtdna) at pallasjärvi, northern finland. lung tissue samples of 171 bank voles (myodes glareolus) trapped in september 1998 were screened for the presence of puuv nucleocapsid antigen and 25 were found to be positive. partial sequences of the puuv small (s), medium (m) and large (l) genome segments were recovered from thes ... | 2009 | 19386780 |
| temporal and geographic evidence for evolution of sin nombre virus using molecular analyses of viral rna from colorado, new mexico and montana. | all viruses in the family bunyaviridae possess a tripartite genome, consisting of a small, a medium, and a large rna segment. bunyaviruses therefore possess considerable evolutionary potential, attributable to both intramolecular changes and to genome segment reassortment. hantaviruses (family bunyaviridae, genus hantavirus) are known to cause human hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome. the primary reservoir host of sin nombre virus is the deer mouse (peromyscus ... | 2009 | 19602267 |
| tubular proteinuria and glomerular filtration 6 years after puumala hantavirus-induced acute interstitial nephritis. | we previously found increased urinary protein excretion, glomerular filtration rate (gfr) and blood pressure in a retrospective analysis of patients with previous nephropathia epidemica (ne). here, we evaluated the long-term outcome after ne in a prospectively recruited patient group. | 2009 | 19390211 |
| hantavirus reservoir oligoryzomys longicaudatus spatial distribution sensitivity to climate change scenarios in argentine patagonia. | oligoryzomys longicaudatus (colilargo) is the rodent responsible for hantavirus pulmonary syndrome (hps) in argentine patagonia. in past decades (1967-1998), trends of precipitation reduction and surface air temperature increase have been observed in western patagonia. we explore how the potential distribution of the hantavirus reservoir would change under different climate change scenarios based on the observed trends. | 2009 | 19607707 |
| a proposal for new criteria for the classification of hantaviruses, based on s and m segment protein sequences. | hantaviruses, members of the family bunyaviridae, are the causative agents of hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. hantaviruses are currently demarcated into species based on the guidelines provided by the international committee on taxonomy of viruses (ictv). these guidelines however, are often ignored by the descriptors of novel hantaviruses. with this study we attempted to refine the second ictv guideline for hantavirus species demarcation by phylogen ... | 2009 | 19393771 |
| evidence of circulation of laguna negra-like hantavirus in the central west of brazil: case report. | hantavirus pulmonary syndrome has been reported with increasing frequency in some brazilian regions, but information about viral genetic identification is still limited. recently, the state of mato grosso, in the legal amazon of brazil, experienced a growing number of hantavirus pulmonary syndrome (hps) cases but the genetic characterization of the causative hantavirus is still missing. | 2009 | 19395308 |
| seasonal variation in sin nombre virus infections in deer mice: preliminary results. | the proportion of deer mice (peromyscus maniculatus) with recently acquired sin nombre virus (snv) infections is an indicator of epizootic intensity and may be key in predicting outbreaks of hantavirus cardio-pulmonary syndrome in humans. we investigated whether incidence of recent infections was related to season, sex, reproductive status, or habitat disturbance. in may and september, 2006, we sampled 912 deer mice at six sites in utah. we determined snv antibody prevalence and estimated the nu ... | 2009 | 19395752 |
| sensitivity of andes hantavirus to antiviral effect of human saliva. | 2009 | 19624946 | |
| replication reduction neutralization test, a quantitative rt-pcr-based technique for the detection of neutralizing hantavirus antibodies. | hantaviruses, which are mainly rodent-borne viruses, cause hemorrhagic fever with renal syndrome in the old world, and hantavirus pulmonary syndrome in the new world. a neutralization test based on quantitative rt-pcr, the replication reduction neutralization test (rrnt), was developed for efficient detection of hantavirus-neutralizing antibodies. the effectiveness of the rrnt was evaluated by examining several hantaviruses and hantavirus-specific convalescent human serum samples. all convalesce ... | 2009 | 19406158 |
| evaluation of an enzyme-linked immunosorbent assay based on araraquara virus recombinant nucleocapsid protein. | laboratory diagnosis of hantavirus cardiopulmonary syndrome (hcps) in brazil has been performed mostly by detection of igm antibodies to recombinant antigen purified from sin nombre virus and andes virus (andv). recently, a recombinant nucleocapsid (rn) protein of araraquara virus (arav), a brazilian hantavirus, was obtained in escherichia coli. to evaluate arav rn as antigen for antibody detection, serum samples from 30 patients from argentina seropositive for hantavirus were tested. all sample ... | 2009 | 19635882 |
| [survey on host animal and molecular epidemiology of hantavirus in chuxiong prefecture, yunnan province]. | to determine the hosts of hantavirus (hv) and its molecular epidemiological characteristics, to provide evidence for prevention and control on hemorrhagic fever with renal syndrome (hfrs). | 2009 | 19642377 |
| more than half of the patients with acute puumala hantavirus infection have abnormal cardiac findings. | this study was conducted to determine the frequency, severity and outcome of cardiac findings in patients with acute puumala hantavirus-induced nephropathia epidemica (ne). 70 consecutive, hospital-treated patients with serologically confirmed ne were prospectively examined using serial electrocardiograms (ecg), plasma troponin i, tumour necrosis factor alpha (tnf-alpha), interleukin-6 (il-6), and echocardiography (echo). examinations were repeated after 3 and 12 months. ecg changes were observe ... | 2009 | 18932105 |
| genetic characterization of a juquitiba-like viral lineage in oligoryzomys nigripes in rio de janeiro, brazil. | hantaviruses, family bunyaviridae, are rodent-borne rna viruses that have caused cases of hantavirus cardiopulmonary syndrome (hcps) in various regions of the americas. there are five hantaviral lineages associated with hcps in brazil: juquitiba virus (juqv), araraquara virus (arav), laguna negra-like virus (lnv), castelo dos sonhos virus (casv), and anajatuba virus (anajv). three additional hantaviruses have been described in rodents alone: rio mearim virus, jaborá virus, and a hantavirus linea ... | 2009 | 19660427 |
| the hantavirus glycoprotein g1 tail contains dual cchc-type classical zinc fingers. | hantaviruses are distributed worldwide and can cause a hemorrhagic fever or a cardiopulmonary syndrome in humans. mature virions consist of rna genome, nucleocapsid protein, rna polymerase, and two transmembrane glycoproteins, g1 and g2. the ectodomain of g1 is surface-exposed; however, it has a 142-residue c-terminal cytoplasmic tail that plays important roles in viral assembly and host-pathogen interaction. here we show by nmr, circular dichroism spectroscopy, and mutagenesis that a highly con ... | 2009 | 19179334 |
| [pulmonary and cardiovascular syndrome due to hantavirus: clinical aspects of an emerging disease in southeastern brazil]. | pulmonary and cardiovascular syndrome due to hantavirus is a disease caused by inhalation of aerosols from the excreta of wild rodents contaminated by viruses of the bunyaviridae family. we studied the clinical and laboratory manifestations of 70 cases that occurred in the region of ribeirão preto, sp, brazil, between 1998 and 2007. the frequency of symptoms was as follows: dyspnea (87%), fever (81%), coughing (44%), headache (34%), tachycardia (81%), low arterial blood pressure (56%), metabolic ... | 2009 | 19684976 |
| diagnostic aspects for epidemic hemorrhagic fever in legal medical autopsy: report of 2 cases and review. | epidemic hemorrhagic fever (ehf) is known also as hemorrhagic fever with renal syndrome (hfrs). hantaviruses, a notorious cause of ehf is spreaded by rodents or biting insects, can cause epidemic hemorrhagic fever. this report describes two rare medico-legal autopsy cases died from epidemic hemorrhagic fever. the victims were two male individuals aged 34 years and 29 years. the medico-legal autopsies were requested for alleged medical negligence. in both cases, autopsy reveals lesions to kidneys ... | 2009 | 19269214 |
| hantavirus species in india: a retrospective study. | hantaviruses cause hemorrhagic fever with renal syndrome in europe and asia. there are about 20 documented hantavirus species and newer species are being described worldwide, especially in non-rodent reservoirs, i.e shrews. focus reduction neutralization test is the classical serotyping technique for hantavirus. however, this study employs a previously established serotyping elisa, to retrospectively analyze known hantavirus igg reactive samples for infecting serotypes. the result suggests prese ... | 2009 | 19736405 |
| [serological characteristics of hantaviruses from clinical specimens analyzed in 1998-2008 in the department of virology, public health institute, ostrava]. | in 1998 - 2008, serum samples from 464 patients, predominantly residents of the moravia-silesian region, were examined in the department of virology, public health institute in ostrava, using enzyme-linked immunosorbent assay (elisa) for the detection of specific anti-hantavirus antibodies. seropositivity was ascertained in 41 persons (8.8%). more patients tested seropositive against hantaan virus (24, i.e. 58.5%) than against puumala virus (13, i.e. 31.7%). four persons were reactive against bo ... | 2009 | 19750821 |
| [anterior pituitary lobe atrophy as late complication of hemorrhagic fever with renal syndrome]. | hemorrhagic fever with renal syndrome (hfrs) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of hfrs, while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after recovery stage. | 2009 | 19281130 |
| genotyping of hantaviruses occurring in linyi, china, by nested rt-pcr combined with single-strand conformation polymorphism analysis. | the hemorrhagic fever with renal syndrome (hfrs) incidence rate still holds in high level in some areas of the world, but a reliable and simple typing method that can be used in clinical diagnosis and epidemiologic surveys is not available. in this study, 48 serum samples were collected from patients with hfrs in linyi area, china, that is seriously affected by this disease. the collected samples were analyzed by nested rt-pcr combined with single-strand conformation polymorphism (sscp) for geno ... | 2009 | 19537913 |
| theory of possible effects of the allee phenomenon on the population of an epidemic reservoir. | we investigate possible effects of high-order nonlinearities on the shapes of infection refugia of the reservoir of an infectious disease. we replace fisher-type equations that have been recently used to describe, among others, the hantavirus spread in mouse populations by generalizations capable of describing allee effects that are a consequence of the high-order nonlinearities. after analyzing the equations to calculate steady-state solutions, we study the stability of those solutions and comp ... | 2009 | 19518251 |
| hantavirus pulmonary syndrome in texas: 1993-2006. | hantavirus pulmonary syndrome (hps) is a rare cardiopulmonary disease that was first described after a 1993 epidemic in the southwestern united states. this study reviewed all cases reported in texas to date. | 2009 | 19077779 |
| serological microarray for detection of hsv-1, hsv-2, vzv, and cmv antibodies. | the seroprevalence of human herpesviruses is high and reactivations occur frequently. a microarray was designed and tested for the detection of igg and igm antibodies for puumala hantavirus (puuv) and igg antibodies against four herpesviruses. initially, a microarray platform was set up using an unrelated in-house antigen, puuv recombinant nucleocapsid protein, to optimize the protocol for the detection of antibodies. detection of the four herpesviruses was set up in a microarray using the recom ... | 2009 | 19477202 |
| an outbreak caused by hantavirus in the black sea region of turkey, january-may 2009. | we present a preliminary report of 12 laboratory-confirmed cases of haemorrhagic fever with renal syndrome (hfrs) in turkey, diagnosed between january and may 2009 according to the clinical symptoms and serological confirmation. studies are still ongoing to better understand the dynamics of the reservoir population as well as the epidemiological characteristics and risk factors among humans. | 2009 | 19460288 |
| potential renal sequelae in survivors of hantavirus cardiopulmonary syndrome. | although other hantaviruses are associated with renal manifestations, hantavirus cardiopulmonary syndrome (hcps) has not been associated with such sequelae. the hcps survivors were prospectively evaluated for renal complications. subjects underwent yearly evaluation, laboratory studies, and 24-hour urine collection. thirty subjects were evaluated after recovery from hcps with the first follow-up at a median of 7.4 months after discharge. subjects were a wide age range (18-51) but had an equal ge ... | 2009 | 19190227 |
| is hantavirus important to practitioners? | 2009 | 19434032 | |
| hantavirus pulmonary syndrome: a concise clinical review. | in 1978, hantaviruses were first described as the etiological agent of hemorrhagic fever with renal syndrome (hfrs) in korea. since then, numerous related, enveloped, negative-stranded rna viruses have been identified, forming the genus hantavirus within the family bunyaviridae. these pathogens are distributed worldwide and thus can be classified, on the basis of phylogenetic origins, into old world viruses or new world viruses (ie north, central, and south america). similarly, these viruses cau ... | 2009 | 19434035 |
| phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of parana (southern brazil). | over 1,100 cases of hantavirus pulmonary syndrome (hps) have occurred in brazil since 1993, but little is known about brazilian hantaviruses, and many of their rodent hosts remain unknown. the araucaria hantavirus (arauv) was described recently from hps patients from paraná, in southern brazil, but its host could not be identified. in this study, rodents were captured from regions with high hps prevalence to address this issue. arauv rna was detected in three distantly related rodent species: ol ... | 2009 | 19439554 |
| the hantaviral load in tissues of naturally infected rodents. | hantaviruses cause a lifelong and asymptomatic infection in naturally infected hosts as well as in experimentally infected rodents. understanding the ecology and pathogenesis of hantaviruses requires an interdisciplinary research approach, which links laboratory experiments with results gained from field studies. although several studies report hantavirus persistence and tissue infection patterns for experimentally infected rodents, field data is very limited. for this reason, the aim of our stu ... | 2009 | 19397875 |
| adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus. | hantaviruses infect humans following aerosolization from rodent feces and urine, producing hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. due to the high rates of mortality and lack of therapies, vaccines are urgently needed. nonreplicating adenovirus (ad) vectors that express andes hantavirus (andv) nucleocapsid protein (adn) or glycoproteins (adg(n) and adg(c)) were constructed. ad vectors were tested for their ability to protect syrian hamsters from a lethal andv inf ... | 2009 | 19403663 |
| seroepidemiological study in a puumala virus outbreak area in south-east germany. | puumala virus (puuv) is the cause of the majority of haemorrhagic fever with renal syndrome cases in germany. in 2004, a nephropathia epidemica outbreak was recorded in lower bavaria, south-east germany. for a seroepidemiological study in this region including the resident population at four locations (n = 178) and soldiers from one location (n = 208) indirect immunoglobulin m (igm) and immunoglobulin g (igg) enzyme-linked immunosorbent assays (elisas) and immunoblot tests based on a yeast-expre ... | 2009 | 19148676 |
| seoul virus and hantavirus disease, shenyang, people's republic of china. | an outbreak of hemorrhagic fever with renal syndrome (hfrs) occurred among students in shenyang pharmaceutical university in 2006. we conducted a study to characterize etiologic agents of the outbreaks and clarify the origin of hantaviruses causing infections in humans and laboratory animals. immunoglobulin (ig) m or igg antibodies against seoul virus (seov) were detected in the serum samples of all 8 patients. igg antibodies against hantavirus were also identified in laboratory rats, which were ... | 2009 | 19193263 |
| hanta virus infection during dengue virus infection outbreak in indonesia. | to investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the who criteria for dengue, in which serologically were not confirmed for dengue virus infections. | 2009 | 19390126 |
| contact heterogeneity in deer mice: implications for sin nombre virus transmission. | heterogeneities within disease hosts suggest that not all individuals have the same probability of transmitting disease or becoming infected. this heterogeneity is thought to be due to dissimilarity in susceptibility and exposure among hosts. as such, it has been proposed that many host-pathogen systems follow the general pattern whereby a small fraction of the population accounts for a large fraction of the pathogen transmission. this disparity in transmission dynamics is often referred to as ' ... | 2009 | 19129136 |
| [rodents and rodent associated disease vectors: the network of "rodent carrying pathogens" introduces itself]. | 2009 | 19263029 | |
| host switch during evolution of a genetically distinct hantavirus in the american shrew mole (neurotrichus gibbsii). | a genetically distinct hantavirus, designated oxbow virus (oxbv), was detected in tissues of an american shrew mole (neurotrichus gibbsii), captured in gresham, oregon, in september 2003. pairwise analysis of full-length s- and m- and partial l-segment nucleotide and amino acid sequences of oxbv indicated low sequence similarity with rodent-borne hantaviruses. phylogenetic analyses using maximum-likelihood and bayesian methods, and host-parasite evolutionary comparisons, showed that oxbv and asa ... | 2009 | 19394994 |
| hantavirus pulmonary syndrome, central plateau, southeastern, and southern brazil. | hantavirus pulmonary syndrome (hps) is an increasing health problem in brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily sigmodontinae rodents, which serve as hantavirus reservoirs. from 1993 through june 2007, a total of 884 cases of hps were reported in brazil (case-fatality rate 39%). to better understand this emerging disease, we collected 89 human serum samples and 68 rodent lung samples containing antibodies to hantavirus f ... | 2009 | 19331732 |
| secretory expression and purification of recombinant escherichia coli heat-labile enterotoxin b subunit and its applications on intranasal vaccination of hantavirus. | in order to further study the b subunit of the escherichia coli heat-labile enterotoxin (ltb), we obtained the ltb gene from pathogenic e. coli, cloned it into the pet22b (+) prokaryotic expression vector, and expressed it as a fusion protein with his tag in e. coli bl21 (de3). the recombinant ltb was expressed and purified by ni2+ affinity chromatography. the biological activity of the purified recombinant ltb was assayed in a series of monosialotetrahexosylganglioside (gm1)-elisa experiments. ... | 2009 | 19089660 |
| central nervous system complications following hanta virus cardiopulmonary syndrome. | 2009 | 19089788 | |
| characterization of hantaviruses circulating in central brazil. | in 2004, an outbreak of hcps in brazil made hantaviruses a national threat to the rural and urban population. during this outbreak, 164 cases were reported, and 18.3% of them occurred in the federal district. in this study, hantavirus genomic sequences were amplified from seven patients who resided in central brazil and then sequenced and compared to other hantavirus sequences. the complete s segment sequence, which is 1847 bases long and potentially encodes the 428 amino acid nucleocapsid prote ... | 2009 | 19103306 |
| ecology, genetic diversity, and phylogeographic structure of andes virus in humans and rodents in chile. | andes virus (andv) is the predominant etiologic agent of hantavirus cardiopulmonary syndrome (hcps) in southern south america. in chile, serologically confirmed human hantavirus infections have occurred throughout a wide latitudinal distribution extending from the regions of valparaíso (32 to 33 degrees s) to aysén (46 degrees s) in southern patagonia. in this study, we found seropositive rodents further north in the coquimbo region (30 degrees s) in chile. rodent seroprevalence was 1.4%, with o ... | 2009 | 19116256 |
| characterization of imjin virus, a newly isolated hantavirus from the ussuri white-toothed shrew (crocidura lasiura). | until recently, the single known exception to the rodent-hantavirus association was thottapalayam virus (tpmv), a long-unclassified virus isolated from the asian house shrew (suncus murinus). robust gene amplification techniques have now uncovered several genetically distinct hantaviruses from shrews in widely separated geographic regions. here, we report the characterization of a newly identified hantavirus, designated imjin virus (mjnv), isolated from the lung tissues of ussuri white-toothed s ... | 2009 | 19357167 |
| hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa b. | hantaviruses such as hantaan virus (htnv) and andes virus cause two human diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, respectively. for both, disease pathogenesis is thought to be immunologically mediated and there have been numerous reports of patients with elevated levels of proinflammatory and inflammatory cytokines, including tumor necrosis factor alpha (tnf-alpha), in their sera. multiple viruses have developed evasion strategies to circumvent the host ... | 2009 | 19019947 |
| hantavirus infections in europe: from virus carriers to a major public-health problem. | in europe, hantavirus disease or hemorrhagic fever with renal syndrome is an endemic zoonosis that affects tens of thousands of individuals each year. the causative agents are viruses of the genus hantavirus, family bunyaviridae, rodents and insectivores act as carriers. in all european countries there is a seroprevalence for hantaviruses in the general population but not all countries report cases. here, we give an overview of the hantavirus situation in europe. | 2009 | 19254169 |
| plagues in the icu: a brief history of community-acquired epidemic and endemic transmissible infections leading to intensive care admission. | the ability to diagnose and treat infectious diseases and handle infectious disease outbreaks continues to improve. for the most part, the major plagues of antiquity remain historical footnotes, yet, despite many advances, there is clear evidence that major pandemic illness is always just one outbreak away. in addition to the hiv pandemic, the smaller epidemic outbreaks of legionnaire's disease, hantavirus pulmonary syndrome, and severe acute respiratory syndrome, among many others, points out t ... | 2009 | 19268795 |
| hantaan virus triggers tlr3-dependent innate immune responses. | immediately after viral infection, innate responses including expression of ifn-alpha/beta and ifn-stimulated genes (isgs) are elicited ubiquitously by recruitment of specific pathogen recognition receptors. the velocity to induce ifn-alpha/beta and isgs in response to an infection is often decisive for virulence. interestingly, in primary endothelial cells isgs are induced later by hantaviruses pathogenic to humans than those considered to be nonpathogenic or of low virulence. here we demonstra ... | 2009 | 19234180 |
| association between habitat and prevalence of hantavirus infections in bank voles (myodes glareolus) and wood mice (apodemus sylvaticus). | in order to determine the habitat preferred by myodes (before clethrionomys) glareolus and the corresponding puumala hantavirus seroprevalence in those habitats, we captured rodents simultaneously in three significantly different habitats. we compared trapping success and presence of virus per habitat during an ongoing epidemic in order to test the hypothesis of a density-dependent seroprevalence. our study showed that bank vole population density, as well as puumala virus seroprevalence, were h ... | 2009 | 19271997 |
| drug targets in infections with other emerging viruses: influenza viruses, metapneumovirus and hantaviruses. | among emergent and re-emergent viral infections, influenza, hemorrhagic fevers, including hantaviruses, constitute one of the major threats to human beings. advances in immunopathogenesis of these viral infections have improved initial supportive treatments and led to recognition and adoption of several useful antiviral agents. this review focuses on therapeutic and preventive aspects of these viral infections, and evaluates old and new promising agents are in the pipeline of pharmaceutical comp ... | 2009 | 19275703 |
| andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) is a highly pathogenic emerging disease (40% case fatality rate) caused by new world hantaviruses. hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. at present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hos ... | 2009 | 19279096 |
| acute febrile illness caused by hantavirus: serological and molecular evidence from india. | study of hantavirus infections in india is in its early stages. as early symptoms of hantavirus disease can be non-specific and the diagnosis confirmed only by laboratory testing, use of appropriate diagnostic tools is important. to improve the diagnosis of hantavirus infections in india, commercial elisa systems followed by indirect immunofluorescence assays were used to detect anti-hantavirus igm and igg in samples from patients with acute febrile illness. of 347 patients tested, 5.2% showed s ... | 2009 | 19237179 |
| a newly recognized hantavirus in the asian house rat (rattus tanezumi) in indonesia. | hantaviral sequences were recovered from the lung tissue of an asian house rat (rattus tanezumi) captured in serang, indonesia. phylogenetic analysis of partial l, m and s segment sequences showed that they belonged to a novel hantavirus provisionally named serang virus (serv). notably, serv is distinct from the hantaviruses associated with rodents of the species rattus: seoul virus associated with rattus norvegicus worldwide and gou virus isolated from rattus rattus in china. instead serv appea ... | 2009 | 19088290 |
| relating increasing hantavirus incidences to the changing climate: the mast connection. | nephropathia epidemica (ne), an emerging rodent-borne viral disease, has become the most important cause of infectious acute renal failure in belgium, with sharp increases in incidence occurring for more than a decade. bank voles are the rodent reservoir of the responsible hantavirus and are known to display cyclic population peaks. we tried to relate these peaks to the cyclic ne outbreaks observed since 1993. our hypothesis was that the ecological causal connection was the staple food source fo ... | 2009 | 19149870 |
| healthcare-associated atypical pneumonia. | atypical pneumonia was first described in 1938, and over time, mycoplasma, legionella, and chlamydophila were the agents commonly linked with community-associated atypical pneumonia. however, as technology has improved, so has our understanding of this clinical entity. it is now known that there are many agents linked with atypical pneumonia in the community, and many of these agents are also major causes of healthcare-associated pneumonia. this article discusses the history, epidemiology, and p ... | 2009 | 19199189 |
| survey for antibody to hantaviruses in tamaulipas, mexico. | wild rodents (n=248) were trapped in two ecologically distinct sites at el cielo biosphere reserve in the state of tamaulipas, mexico, during the summer of 2003. samples from 199 individuals were tested for hantavirus antibodies by an indirect enzyme-linked immunosorbent assay (elisa). hantavirus antibodies to recombinant sin nombre virus nucleocapsid protein were found in seven rodents (3.5%) of a single species, peromyscus levipes. antibody-positive rodents were found only in the cloud forest ... | 2009 | 19204351 |
| hantavirus disease (nephropathia epidemica) in belgium: effects of tree seed production and climate. | recently, human cases of nephropathia epidemica (ne) due to puumala virus infection in europe have increased. following the hypothesis that high reservoir host abundance induces higher transmission rates to humans, explanations for this altered epidemiology must be sought in factors that cause bank vole (myodes glareolus) abundance peaks. in western europe, these abundance peaks are often related to high tree seed production, which is supposedly triggered by specific weather conditions. we evalu ... | 2009 | 18606026 |
| hantavirus evolution in relation to its rodent and insectivore hosts: no evidence for codivergence. | hantaviruses are considered one of the best examples of a long-term association between rna viruses and their hosts. based on the appearance of strong host specificity, it has been suggested that hantaviruses cospeciated with the rodents and insectivores they infect since these mammals last shared a common ancestor, approximately 100 million years ago. we tested this hypothesis of host-virus codivergence in two ways: 1) we used cophylogenetic reconciliation analysis to assess the fit of the viru ... | 2009 | 18922760 |
| construction and expression of a eukaryotic expression vector containing a fusion gene of the hantaan virus s gene and hsp70 gene. | hantavirus (hv) infection leads to a kind of severe systematic syndrome, hemorrhagic fever with renal syndrome (hfrs). heat shock proteins (hsps) can be used as adjuvants assisting soluble antigens to produce specific targets which can be attacked by cytotoxic t lymphocytes. for further research on hfrs vaccine, this study aimed to express hantaan virus nucleocapsid protein (htnv np)-hsp70 fusion protein in cos-7 cells. first, an htnv s gene encoding np was amplified by pcr with a mutated termin ... | 2009 | 18810536 |
| one for all? a viral protein supplants the mrna cap-binding complex. | 2009 | 19129761 | |
| predicting high risk for human hantavirus infections, sweden. | an increased risk for hemorrhagic fever with renal syndrome caused by puumala hantavirus was forecast for sweden in 2007. the forecast was based on a predicted increase in the number of myodes glareolus rodents (reservoir hosts). despite raised awareness and preparedness, the number of human cases during july 2007-june 2008 was 1,483, a new high. | 2009 | 19116065 |
| bovine and human-derived passive immunization could help slow a future avian influenza pandemic. | an epidemic of human transmitted avian influenza could have casualties on a scale seen in the great spanish influenza pandemic of 1918. this paper proposes that should such occur before effective vaccines and antiviral drugs are available, the outbreak could be significantly slowed by consumption of raw milk produced by herds of pathogen-free lactating cows intranasally inoculated with heat-sterilized sputa pooled from avian influenza patients, supplemented by parenteral serum immune globulin fr ... | 2009 | 18824305 |
| recent approaches in hantavirus vaccine development. | rodent-borne hantaviruses are associated with two main clinical disorders in humans: hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. although hantavirus diseases can be life threatening and numerous research efforts are focused on the development of hantavirus prevention, no specific antiviral therapy is yet available and, at this time, no who-approved vaccine has gained widespread acceptance. this review will summarize the current knowledge and recent progress as ... | 2009 | 19093774 |
| role of the nss protein in the zoonotic capacity of orthobunyaviruses. | the family bunyaviridae contains over 350 named isolates, classified into five genera: orthobunyavirus, hantavirus, nairovirus, phlebovirus and tospovirus. the orthobunyavirus genus contains some 170 isolates that are mainly transmitted by mosquitoes and are responsible for a range of disease syndromes in humans including self-limiting febrile illness, encephalitis and haemorrhagic fever. the viruses have a tripartite, negative-sense rna genome. analyses of viruses in four serogroups (bunyamwera ... | 2009 | 18771514 |
| serological and genetic evidence for the presence of seoul hantavirus in rattus norvegicus in flanders, belgium. | seoul hantavirus (seov), carried by rattus rattus (black rat) and r. norvegicus (norway, brown rat), was reported to circulate as well as cause hfrs cases in asia. as rattus sp. are present worldwide, seov has the potential to cause human disease worldwide. in europe however, only seov prevalence in rats from france was reported and no confirmed cases of seov infection were published. we here report genetic and serological evidence for the presence of seov virus in brown rat populations in belgi ... | 2009 | 18821445 |
| nephropathia epidemica with a 6-week incubation period after occupational exposure to puumala hantavirus. | serological and molecular evidence showed that a german female student became infected by puumala hantavirus during mice trapping efforts in finland. the incubation period before exhibiting clinical signs of nephropathia epidemica was as long as 6 weeks. phylogenetic analysis of puuv nucleic acid sequences amplified from the patient demonstrate that she was infected by the puuv strain circulating at the place of her occupational exposure in finland. | 2009 | 19058998 |
| environmental and ecological potential for enzootic cycles of puumala hantavirus in great britain. | puumala virus (puuv) is a zoonotic rodent-borne hantavirus in continental europe. its reservoir host, the bank vole (myodes glareolus), is ubiquitous in great britain (gb); however, there has been no reported incidence of virus in either animals or humans. in northwest europe, increases in bank vole numbers, stimulated by increases in production of beech/oak crops (mast), are associated with outbreaks of nephropathia epidemica (ne) in humans. these so-called 'mast years' are determined by sequen ... | 2010 | 19563697 |
| extinction of refugia of hantavirus infection in a spatially heterogeneous environment. | we predict an abrupt observable transition, on the basis of numerical studies, of hantavirus infection in terrain characterized by spatially dependent environmental resources. the underlying framework of the analysis is that of fisher equations with an internal degree of freedom, the state of infection. the unexpected prediction is of the sudden disappearance of refugia of infection in spite of the existence of supercritical (favorable) food resources, brought about by reduction of their spatial ... | 2010 | 20866661 |
| models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission. | hantavirus, a zoonotic disease carried by wild rodents, is spread among rodents via direct contact and indirectly via infected rodent excreta in the soil. spillover to humans is primarily via the indirect route through inhalation of aerosolized viral particles. rodent-hantavirus models that include direct and indirect transmission and periodically varying demographic and epidemiological parameters are studied in this investigation. two models are analyzed, a nonautonomous system of differential ... | 2010 | 20462286 |
| [hantavirus infection associated to a staphylococcal sepsis. report of one case]. | we report a previously healthy 36-year-old mole who developed a pulmonary syndrome caused by hantavirus infection. he was admitted to an intensive care unit in shock and respiratory failure and died four hours after admission. blood cultures were positive for staphylococcus aureus. this patient could be an index case that shows, for the first time, an association of hantavirus pulmonary syndrome with staphylococcus aureus infection similar to what happens with other viruses. | 2010 | 20556338 |
| characterization of a natural focus of puumala hantavirus infection in the czech republic. | hantaviruses are rna viruses of the bunyaviridae family, represented in the czech republic by three genospecies: dobrava-belgrade, puumala and tula. they persist in natural foci of infection. in 2004 to 2009, a local outbreak with 18 reported cases of nephropathia epidemica caused by puumala hantavirus occurred in the sumava mountains and foothills and was spacially associated with another outbreak in lower bavaria, germany. in the jeleni locality in the sumava mountains at 880 m above sea level ... | 2010 | 20939264 |
| [hantavirus]. | 2010 | 20942073 | |
| the severity of puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than c-reactive protein determinations. | nephropathia epidemica (ne) is a scandinavian type of hemorrhagic fever with renal syndrome caused by puumala hantavirus. the clinical course of the disease varies greatly in severity. the aim of the present study was to evaluate whether plasma c-reactive protein (crp) and interleukin (il)-6 levels associate with the severity of ne. | 2010 | 20500875 |
| new world hantaviruses activate ifnlambda production in type i ifn-deficient vero e6 cells. | hantaviruses indigenous to the new world are the etiologic agents of hantavirus cardiopulmonary syndrome (hcps). these viruses induce a strong interferon-stimulated gene (isg) response in human endothelial cells. african green monkey-derived vero e6 cells are used to propagate hantaviruses as well as many other viruses. the utility of the vero e6 cell line for virus production is thought to owe to their lack of genes encoding type i interferons (ifn), rendering them unable to mount an efficient ... | 2010 | 20567522 |