Publications

coagulopathy in patients with hemorrhagic fever with renal syndrome.	hemorrhagic fever with renal syndrome in korea (korean hemorrhagic fever) is an acute viral disease characterized by fever, hemorrhage and renal failure. in korean patients, the disease manifests more distinctive bleeding tendencies than those of hemorrhagic fever with renal syndrome found in western countries. to investigate the nature and role of the coagulation, fibrinolysis, kinin and immune system in the pathogenesis of such a hemorrhagic manifestation, alterations of these systems were ass ...	1987	3151765
morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome. ii. inclusion bodies--ultrastructural markers of hantavirus-infected cells.	three distinctive types of viral inclusion bodies were identified in hantavirus-infected cells by thin-section electron microscopy. the inclusion bodies, designated granular, granulofilamentous, and filamentous, were intracytoplasmic and closely associated with the rough endoplasmic reticulum and golgi cisternae. virus specificity of the inclusions was verified by immune colloidal gold and immunoperoxidase labeling. the inclusion bodies were a common morphological marker for 13 strains of hantav ...	1987	3610571
[serological demonstration of the presence of hantaan virus in rattus norvegicus rats in a rural environment in france].		1987	2951694
[serological demonstration of the presence of hantaan virus in rattus norvegicus rats in an urban environment in france].		1987	2951696
hantaan virus m rna: coding strategy, nucleotide sequence, and gene order.	the m genome segment of hantaan virus was molecularly cloned and the nucleotide sequence of cdna was determined. the virion rna is 3616 bases long with 3'- and 5'-terminal nucleotide sequences complementary for 18 bases. a single long open reading frame in the viral complementary-sense rna had the potential to encode 1135 amino acids or a polypeptide of 126,000 da. amino-terminal sequences of isolated g1 and g2 envelope glycoproteins were determined, revealing a gene order with respect to messag ...	1987	3103329
four serotypes of haemorrhagic fever with renal syndrome viruses identified by polyclonal and monoclonal antibodies.	antigenic relationships among 20 strains of haemorrhagic fever with renal syndrome (hfrs) viruses isolated in korea, china, u.s.s.r., finland, japan and u.s.a. were examined with rat immune sera, patient sera, eight monoclonal antibodies against the sr-11 strain and 10 monoclonal antibodies against the 76-118 strain. antigen analyses by indirect immunofluorescent antibody and immune adherence haemagglutination tests using polyclonal and monoclonal antibodies demonstrated that hrfs viruses may be ...	1987	3106565
epizootiology of hantavirus infections in baltimore: isolation of a virus from norway rats, and characteristics of infected rat populations.	rats trapped from 14 locations in baltimore, maryland, were shown to have antibody to hantavirus. antibody prevalence rates were higher in residential locations than in parks. infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection in urban rats in the united states. prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired ...	1987	3109236
parasites, diseases and health status of sympatric populations of sambar deer and white-tailed deer in florida.	from december 1983 to december 1984 a study on parasites, diseases and health status was conducted on sympatric populations of sambar deer (cervus unicolor) and white-tailed deer (odocoileus virginianus) from st. vincent island, franklin county, florida. ten sambar and six white-tailed deer were examined. white-tailed deer had antibodies to epizootic hemorrhagic disease virus and bluetongue virus. serologic tests for antibodies to the etiologic agents of bovine virus diarrhea, infectious bovine ...	1987	3035242
[immunocolloidal gold labelling electron microscopy and its application in studying the morphology of viruses].		1987	3036385
[hemorrhagic fever viruses. principal epidemiologic aspects].		1987	3038354
[persistent infection caused by hemorrhagic fever with renal syndrome virus in bank voles (clethrionomys glareolus)--the natural host of the virus].		1987	2907924
[determination of specific immune complexes and dynamics of their circulation in patients with hemorrhagic fever with renal syndrome].		1987	2907925
[transmission of epidemic hemorrhagic fever virus between mice and mites in ehf endemic areas].		1987	2898326
haemorrhagic fever with renal syndrome: clinical, virological and epidemiological perspectives.	haemorrhagic fever with renal syndrome (hfrs) is caused by a group of rna viruses within the family of bunyaviridae known as hantaviruses. the classical, severe form of hfrs is characterized by fever, headache, abdominal and lumbar pain, proteinuria, haemorrhagic phenomena, shock and renal failure. the disease is associated with the prototype hantaan virus and occurs in rural areas of korea and china with apodemus mice as reservoir hosts. a clinically less severe form of hfrs, which is caused by ...	1987	2895603
epidemiology of nephropathia epidemica in sweden.	a comprehensive study of nephropathia epidemica (ne), caused by puumala virus, was conducted in sweden. human sera from residents of various regions of sweden were examined for antibody to puumala virus, and the incidence of ne was determined. small mammals were captured at locations throughout sweden and were examined for antibody to puumala virus and for antigen. the human serosurvey found the highest prevalence rates and the highest incidence rates in northern sweden. the bank vole was found ...	1987	2879874
[antigenic components of the epidemic hemorrhagic fever virus].		1987	2443227
characterization of hantaviruses using monoclonal antibodies.	the antigenic relations among nine hantaviruses from seven different geographic areas were examined in indirect fluorescent antibody test with 12 monoclonal antibodies. ten monoclonals were prepared against hantaan virus strain 76-118 and two against hantavirus b-1, a virus isolated from a tumour in a laboratory rat. four different serotypes have been differentiated: hällnäs, hantaan, prospect hill and rat strain like. two monoclonal antibodies were able to react with all nine hantaviruses studi ...	1987	2449811
[antigenicity analysis of hemorrhagic fever with renal syndrome viruses by mcabs i].		1987	2450686
[circulation of the virus of hemorrhagic fever with renal syndrome among small mammals in the territory of the ussr].	over 55,000 small mammals of 72 species trapped in 62 administrative territories practically in all landscape-geographical zones of the ussr were examined in 1980-1985. the use of current laboratory methods demonstrated a wide spread of hfrs virus in the territory of this country, involvement in the epizootic process of most species of forest and steppe murine rodents and insectivora. in each landscape zone, the main carriers of the hfrs agent were established, represented, as a rule, by the bas ...	1987	2451354
effects of human and murine interferons against hemorrhagic fever with renal syndrome (hfrs) virus (hantaan virus).	the effects of human interferons (ifn-alpha, ifn-beta, ifn-gamma) on the replication of hantaan virus (hv) in vero e6 cells were examined. pretreatment of cells with human ifns resulted in dose-dependent inhibition of hv plaque formation. of the 3 human ifns, ifn-beta inhibited virus replication most effectively. pretreatment of murine macrophage cells with mouse ifn-beta also resulted in an inhibition of viral growth and then the effect of murine ifn-beta in newborn icr mice infected with hv wa ...	1987	2451468
[antigenic analysis of hemorrhagic fever with renal syndrome viruses (hfrs) using monoclonal antibodies].		1987	2452029
[combined extracorporeal detoxification of the blood and lymphatic drainage in hemorrhagic fever with renal syndrome].		1987	2883340
occurrence and distribution of hantavirus in wild living mammals in belgium.	small mammals were screened for the presence of antibodies to hantaan virus (htn) and hantavirus (hv) antigen in belgium. antibody and antigen-positive animals were found in different parts of the country. one insectivore and five rodent species were found positive. the highest prevalence of infection was found in the bank vole (clethrionomys glareolus). a relation between infected animals and wet habitats was observed. it was obvious that in bank vole the likelihood of infection increased with ...	1987	2883857
detection of specific serum immunoglobulin m in nephropathia epidemica (scandinavian epidemic nephropathy) by a biotin-avidin-amplified immunofluorescence method.	a biotin-avidin-amplified indirect immunofluorescence method was used to demonstrate specific serum immunoglobulin m (igm) antibodies in nephropathia epidemica, the scandinavian type of hemorrhagic fever with renal syndrome. the antigen in the test was the cross-reacting agent of korean hemorrhagic fever, hantaan virus. sixty-two serum samples from 15 patients with clinically typical nephropathia epidemica were analyzed. eleven patients had specific igm in one or more serum samples. the igm coul ...	1987	2885340
role of t lymphocyte subsets in protection and recovery from hantaan virus infection in mice.	adult athymic nude (balb/c background) mice or inbred balb/c mice were inoculated intraperitoneally with hantaan virus (hv), and attempts were made to isolate the virus from brain, lung and spleen. virus was isolated from the organs of balb/c mice for only a short time after infection but was isolated from various organs of nude mice consistently for at least 84 days after infection. viral antigen was also detected in various organs of nude mice for a long time after infection. the effects of ad ...	1987	2885394
[acute interstitial nephritis].		1987	2885911
partial characterization of a hantavirus isolated from a clethrionomys glareolus captured in belgium.	a hantavirus was isolated in vero-e6 cells from lungs of a free living bank vole (clethrionomys glareolus) captured in turnhout, province of antwerp--northern part of belgium. with help of monoclonal antibodies the belgian hantavirus isolate could be clearly differentiated from hantaan virus strain 76-118, prospect hill virus strain ph1 and sr11, a hantavirus isolated from laboratory wistar rat in japan, but not from the nephropathia epidemica virus strain hällnäs.	1987	2886029
detection of hantaviruses with rna probes generated from recombinant dna.	radiolabeled rna probes generated from cdna clones of the m and s genome segments of hantaan virus readily detected hantaan virus and two isolates from korean hemorrhagic fever patients but were less effective in detecting four other hantaviruses.	1987	2886113
[hemorrhagic fever with the renal syndrome].		1987	2887068
acute hantavirus nephropathy in belgium: preliminary results of a sero-epidemiological study.		1987	2887093
[study on the spread of hemorrhagic fever with renal syndrome among animal hosts].		1987	2887291
bluetongue and epizootic hemorrhagic disease in white-tailed deer from oklahoma: serologic evaluation and virus isolation.	blood samples were collected from 194 white-tailed deer from 27 locations in oklahoma from 1977 through 1984. sixty-eight (35%) of the deer had antibody against bluetongue virus (btv) and 78 (40%) had antibody against epizootic hemorrhagic disease virus. seropositive deer were detected in each of the 4 geographic quadrants of the state. virus isolation was attempted in 40 deer from the northeast quadrant of oklahoma (1983 through 1984); btv was isolated from 11 deer, but epizootic hemorrhagic di ...	1987	2888426
[the first isolation of the hfrs virus from the lung of rattus norvegicus and the blood of patients in jinzhou prefecture].		1987	2888536
early diagnosis of hemorrhagic fever with renal syndrome by igm elisa technique.		1987	2888601
clinical and epidemiological aspects of hemorrhagic fever with renal syndrome (hfrs) in greece.	twenty-three cases of hemorrhagic fever with renal syndrome were serologically diagnosed in rural populations of greece between 1982 and 1985. the clinical picture of the disease was severe, (3 deaths recorded among 23 cases) and more closely resembled korean hemorrhagic fever than nephropathia epidemica. examination of patients' sera by indirect immunofluorescence (ifa) assays and plaque reduction neutralization (prnt) tests using hantaan 76-118, puumala, and seoul (urban rat-associated hantaan ...	1987	2888688
cats--source of protection or infection? a case-control study of hemorrhagic fever with renal syndrome.	in the first case-control study analyzing risk factors in sporadic hemorrhagic fever with renal syndrome, 111 cases occurring in shanghai in 1983 and 1984 and 136 matched controls were studied. three factors were associated with risk of disease: travel in the month before onset of illness, intense exposure to rodents in the home, and cat ownership. risk associated with cat ownership was not confounded by exposure to rodents in the home. neither cat ownership nor risk associated with rodent expos ...	1987	2889355
zoonotic implications of hantaan-like viruses: an introduction.		1987	2889843
epidemiology of hantaan and related viruses.	hantaan and related viruses, the causative agents of hemorrhagic fever with renal syndrome (hfrs), are significant human pathogens. current epidemiologic evidence indicates that these pathogens are disturbed more widely than once believed, and they are likely to cause disease when man comes into close contact with infected rodents. this report summarizes the characteristics of the hantaanp-related viruses of the genus hantavirus including epidemiology, ecological characteristics, routes of trans ...	1987	2889844
hemorrhagic fever with renal syndrome: mode of transmission to humans.	hemorrhagic fever with renal syndrome (hfrs) is a viral disease spread to humans from persistently infected rodents and other small mammals. the consensus of opinion regarding the mechanism of transmission to man indicates a principal role for respiratory infection from aerosols of infectious virus from rodent urine, feces and saliva. interhuman, secondary spread of infection does not occur. the role of ectoparasites in virus transmission is undefined. however, epidemiologic considerations and v ...	1987	2889846
control of laboratory acquired hemorrhagic fever with renal syndrome (hfrs) in japan.	by the end of 1985, 126 human cases of laboratory acquired hemorrhagic fever with renal syndrome (hfrs) were recorded in japan. seroepidemiological studies revealed that laboratory rats exhibited high ifa titers against hantaan or related viruses at locations where hfrs patients occurred. laboratory researchers contracted hfrs more frequently than laboratory animal technicians or caretakers, although a laboratory animal caretaker died of the disease. inhalation of hfrs-virus contaminated air in ...	1987	2889847
haemorrhagic fever with renal syndrome involving the liver.	a case of haemorrhagic fever with renal syndrome that originated in malaysia is reported. the patient presented with clinical symptoms which were not typical of the disease as seen in endemic regions. renal involvement, which is characteristic of haemorrhagic fever with renal syndrome, was mild, and the predominant symptom was a persistently marked elevation of serum transaminase levels that was suggestive of hepatitis. liver involvement has not been described in the asian form of haemorrhagic f ...	1987	2890086
nephropathia epidemica: incidence of clinical cases and antibody prevalence in an endemic area of sweden.	the incidence of nephropathia epidemica (ne) was compared with the ne antibody prevalence in normal population in a highly endemic area of sweden (västerbotten county). the antibody prevalence rate in the oldest age groups were found to be 14 and 20 times higher than the accumulated life-risk of being hospitalized with ne for men and women respectively. whether the infection in persons not admitted to hospital is subclinical, atypical or clinically fulminant, remains to be determined.	1987	2890534
isolation of a hantavirus from a severely ill patient with hemorrhagic fever with renal syndrome in greece.		1987	2890690
[an epidemiologic study on rats associated with outbreak of hemorrhagic fever with renal syndrome--comparison with antibodies for two virus strain, hantaan virus 76-118 strain and newly isolated wkm strain].		1987	2890696
[an epidemiologic study on hfrs after six years surveillance--comparison with antibodies for two virus strain, hantaan virus 76-118 strain and wkm strain in members of college].		1987	2890697
[detection of foci of hemorrhagic fever with renal syndrome in the estonian ssr].	examination by the enzyme-immunoassay of organs of 10 small mammal species trapped in different landscape zones of the estonian ssr revealed the presence of hfrs virus antigen in organs of bank voles and field mice. radioimmunoassay studies of serum specimens from donors demonstrated the presence of antibody to hfrs virus in 2.54% of those examined.	1987	2891222
antibody to hemorrhagic fever with renal syndrome viruses (hantaviruses) in the united states.	hantaviruses similar to those which cause hemorrhagic fever with renal syndrome have been isolated from rodents in the united states. serologic evidence suggests that these viruses infect humans. clinical disease has not, however, been associated with infection in the united states. to expand knowledge of the distribution of hantaviruses in the united states and attempt to identify a clinical syndrome associated with infection, a serologic survey was undertaken of us forestry service personnel a ...	1987	2891295
prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of baltimore, maryland.	we used a prospective seroepidemiological study, in conjunction with a mark-release-recapture protocol, to investigate the transmission of hantaviruses in four rodent species from baltimore, maryland, from june 1984 to june 1986. a total of 1,208 captures of 762 rodents provided 984 individual blood samples. the antibody prevalence, as determined by frequency of reciprocal indirect fluorescent antibody (ifa) titers greater than or equal to 32, was 33.9% in rats (rattus norvegicus, n = 466), 28.3 ...	1987	2891308
[hemorrhagic fevers with renal syndrome caused by hantaan virus in france].		1987	2892243
hantavirus nephropathy, an unrecognized cause of transient acute renal failure in belgium.		1987	2892329
[hantavirus nephropathy in belgium: description of 2 new cases originating in southern provinces].		1987	2892330
[hantavirus nephropathy: apropos of 4 cases diagnosed in south hainaut].		1987	2892331
hantavirus disease.		1987	2892467
[detection of viral antigens in various organs in 14 fatal cases of epidemic hemorrhagic fever].		1987	2892652
[advances in the diagnosis of epidemic hemorrhagic fever].		1987	2892653
enzyme-linked immunosorbent assay for detection of antibody against hemorrhagic fever with renal syndrome virus in sera from experimentally infected rats.		1987	2892958
[detection of natural foci of the hemorrhagic fever with renal syndrome in the georgian ssr].	the circulation of the causative agent of hemorrhagic fever with renal syndrome (hfrs) in georgia was studied. altogether, 7,938 small mammals of 16 species trapped in 23 administrative areas of the republic were examined, and the specific antigen of hfrs virus was detected in 308 (3.8%). in serological examinations of 10 patients, antibody to hfrs virus was found in 4. analysis of the above results indicates the existence of natural foci of hfrs in the georgian ssr.	1987	2893492
[exact determination of the eastern border of the european portion of the nosogeographic range of the hemorrhagic fever with renal syndrome].	radioimmunoassay was used for examinations of 21,488 serum specimens from the population of 145 areas of 8 regions and 2 republics. the immune portion comprised 8.8% to the west of the assumed border and 2.7% to the east (t = 20.7). active natural foci of the infection were found in individual territories located to the east of the assumed border (areas of saratov province to the north of the irgiz river, trans-ural areas of bashkiria, southern taiga areas of sverdlovsk, tyumen, and northwestern ...	1987	2893493
[experimental study on bitting, trans-stadial and transovarian transmission of epidemic haemorrhagic fever virus by gamasid mites ornithonyssus bacoti].		1987	2894898
serologic differentiation of virus strains of hemorrhagic fever with renal syndrome (hfrs) by monoclonal antibodies.		1987	2895468
serological survey of prospect hill virus infection in indigenous wild rodents in the usa.	we found serological evidence of infection with prospect hill virus, a hantaan-like virus isolated from meadow voles (microtus pennsylvanicus), in microtine and cricetid rodents trapped in maryland, west virginia, minnesota and california, usa. fluorescent antibodies were detected in sera from m. pennsylvanicus (74/277), m. californicus (39/185), clethrionomys gapperi (5/51), peromyscus maniculatus (4/22) and p. truei (1/11). sera from seropositive p. maniculatus contained neutralizing antibodie ...	1987	2895510
first human case of haemorrhagic fever with renal syndrome in the central african republic.		1987	2895515
[detection of natural foci of hemorrhagic fever with renal syndrome in the territory of crimean and chernigov provinces].		1987	2895547
[immuno-histochemical study of experimental epidemic hemorrhagic fever].		1986	2886229
characterization of glycoproteins of viruses causing hemorrhagic fever with renal syndrome (hfrs) using monoclonal antibodies.	viruses causing hemorrhagic fever with renal syndrome (hfrs) encode two glycoproteins, g1 and g2. for determination of the biological functions of these glycoproteins, we isolated 15 hybridomas secreting monoclonal antibodies directed against the glycoproteins of the b-1 and hantaan viruses (hv). from results of neutralizing and hemagglutination inhibition (hi) tests, and studies on the antigenic reactivities of the antibodies with other hv-related viruses by immunofluorescence, we classified th ...	1986	2422813
new isolates of hfrs virus in sichuan, china and characterisation of antigenic differences by monoclonal antibodies.		1986	2423827
[isolation of strains of the virus of hemorrhagic fever with renal syndrome in a cell culture from human patients and rodents].	the virus of hemorrhagic fever with renal syndrome serologically similar to hantaan virus was isolated from three rodent species, ap. peninsulae, cl. rutilus, cl. rufocanus, and from human patients in vero e6 cell culture.	1986	2425494
infection of laboratory workers with hantavirus acquired from immunocytomas propagated in laboratory rats.	hantavirus has been isolated in cell culture from rat immunocytomas used and stored at a research laboratory in the u.k. where there was evidence of a laboratory-acquired infection leading to haemorrhagic fever with renal syndrome. both transplantation into lou/m/wsl rats and storage of passaged immunocytomas at -70 degrees c over a period of 8-10 years had not eliminated the virus. the isolates were identified as hantavirus by means of serum obtained from patients with hantavirus infection as w ...	1986	2871112
detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and korean hemorrhagic fever by using puumala virus cell culture antigen.		1986	2871114
epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in greece.	epidemiological investigations were conducted following an outbreak of hemorrhagic fever with renal syndrome (hfrs) which occurred in the state of epirus, northwestern greece, in july and august 1983. a total of 8 patients were hospitalized during the outbreak; 3 were severely ill and 1 died. a serosurvey made in may 1984 sampled 184 of the approximately 400 residents of the village of tsepelovo, where 4 patients resided, and found 12 (6.5%) persons, including convalescent sera from 4 patients, ...	1986	2871769
epidemiological studies of hemorrhagic fever with renal syndrome (hfrs) related virus infection among urban rats in hokkaido, japan.	seroepidemiological studies of hemorrhagic fever with renal syndrome (hfrs) virus infection were carried out among urban rats (rattus norvegicus and rattus rattus) and small field rodents in hokkaido, japan. an urban rat colony that was seropositive to sr-11 strain of hfrs virus (laboratory rat origin) was demonstrated in february 1983 at a dumping ground area of kami-iso town near hakodate port. an hfrs-related virus, named ki-262 strain, was isolated from the lung tissue of a seropositive rat ...	1986	2871823
growth experiment of hantaan virus in a549 cells: an attempt to improve the immunofluorescent antibody technique for hemorrhagic fever with renal syndrome.	an assay method for the infectivity of hantaan virus, a causative agent of hfrs (hemorrhagic fever with renal syndrome), was developed by the use of ifa (immunofluorescent antibody technique). with the aid of this method, the growth characteristics of hantaan virus, 76-118 strain, were followed in a549 cells. at a maximal moi (multiplicity of infection) of 1.6 vaiu (viral antigen-inducing units) per cell, the conventionally available value, plateau level potencies of the viral antigen and virus ...	1986	2872077
[epidemiologic study of epidemic hemorrhagic fever in guangzhou].		1986	2872966
[hemorrhagic fever with renal syndrome among human populations of tiantai county].		1986	2872967
[results of a humoral immunity study in hemorrhagic fever with renal syndrome in the maritime territory].	the paper presents the results of serological diagnosis of hemorrhagic fever with renal syndrome (hfrs) and studies of the time course of humoral immunity formation in this disease carried out in 1980-1983 in the maritime territory, one of the active hfrs foci.	1986	2873687
serological survey with the antigen of haemorrhagic fever virus with renal syndrome in small rodents in slovakia.	results of serological survey in small rodents with the antigen of haemorrhagic fever with renal syndrome (hfrs) virus indicate the existence of a natural focus of this virus in slovakia. antibodies were found in the following free-living rodent species: clethrionomys glareolus, apodemus agrarius, apodemus sylvaticus, pitymys subterraneus, microtus arvalis and microtus economus. a total 10 out of 120 (8.2%) small rodents trapped in investigated localities of western and eastern slovakia had anti ...	1986	2873734
[sero-types in the hemorrhagic fever renal syndrome: i. an identification of sero-types of hfrs by hemagglutination inhibition assay].		1986	2874886
[electron microscopic study of the morphology of virus of hemorrhagic fever with renal syndrome in suckling mice].		1986	2875562
[antibody formation dynamics in patients from the far east with hemorrhagic fever with renal syndrome].		1986	2876551
animal model of rabbits for researching epidemic hemorrhagic fever.		1986	2876852
comparison of immunofluorescence and hemagglutination inhibition tests and enzyme-linked immunosorbent assay for detection of serum antibody in rats infected with hemorrhagic fever with renal syndrome virus.	serum antibodies against the b-1 strain of hemorrhagic fever with renal syndrome (hfrs) virus in wild and experimental rats were investigated by the indirect immunofluorescent antibody (if) test, the hemagglutination inhibition (hi) test, and an enzyme-linked immunosorbent assay (elisa). in the newly developed elisa, monoclonal antibodies to the b-1 strain were applied as coating antibody. in sera from wild rats, the results obtained by the elisa agreed quite well with those obtained by the hi t ...	1986	2877007
[clinical features, laboratory data and anti-viral antibody titers in a severe case of hemorrhagic fever with renal syndrome (hfrs)--a one-month course from onset].		1986	2877038
ecological and epidemiological data on hantavirus in bank vole populations in belgium.	epidemiological and ecological data of a hantavirus infected bank vole population were collected using live-trapping methods. a close association between the distribution of hv-infected bank voles and wet habitat types was found. several seroconversions were observed during the life of individual bank voles. all seroconversions occurred within the wet habitat types and only after a certain age was reached. survival of hv-infected bank voles did not differ from not-infected animals. in the labora ...	1986	2877647
the antigenic analysis of haemorrhagic fever with renal syndrome viruses in china by monoclonal antibodies.	thirty-six strains of haemorrhagic fever with renal syndrome (hfrs) virus were isolated from patients and a number of host animals in various areas in china. they were analysed by an immunofluorescence test (ifat) using 10 monoclonal antibodies (mcabs) specific for the hfrs virus; antigenic differences among the strains have been demonstrated. the hfrs virus strains revealed nine different reactions with the mcabs, showing that there are at least nine different antigenic determinants including g ...	1986	2878042
[experimental study on natural infection, biting and transovarial transmission of epidemic haemorrhagic fever virus in gamasid mites].		1986	2878731
persistent infection of rats with haemorrhagic fever with renal syndrome virus and their antibody responses.	newborn (within 24 h after birth), 1-week-old and 6-week-old (adult) rats were inoculated with a hantaan-related virus (b-1) and attempts were made to isolate the virus from various organs. virus-specific antigens were detected in various organs of newborn rats. moreover virus could be isolated from almost all their organs even 25 weeks after infection. in contrast, in rats infected at 6 weeks of age the virus could be isolated from various organs but its concentration decreased progressively wi ...	1986	2878971
[hemorrhagic fever with renal syndrome in madagascar. first seroepidemiologic survey of rat populations].		1986	2879517
[serological data on hemorrhagic fever with renal syndrome in southeast asia].	using an indirect immunofluorescent test with hantaan 76-118 and puumala strains as antigens, antibodies against haemorrhagic fever with renal syndrome viruses were found for the first time in human in laos and viet-nam and confirmed the previously published results in thailand. these results suggest the existence of an hantaan-related virus in these countries.	1986	2879646
some biological properties of virus strains isolated from hemorrhagic fever patients with renal syndrome.		1986	2879712
serologic survey of selected pathogens in white-tailed and mule deer in western nebraska.	exposure of free-ranging white-tailed deer (odocoileus virginianus) and mule deer (odocoileus hemionus) in western nebraska to selected livestock pathogens was determined by serology and attempted virus isolation. antibodies to bluetongue virus, epizootic hemorrhagic disease virus, and bovine respiratory syncytial virus were present in both species of deer. no serologic reactors to brucella or anaplasma were found. attempts to isolate bluetongue virus were negative.	1986	2845156
[hemorrhagic fever with a renal syndrome].		1986	2882632
haemagglutination-inhibition test for haemorrhagic fever with renal syndrome using virus antigen prepared from infected tissue culture fluid.	haemagglutinating (ha) antigens of four strains of virus related to that causing haemorrhagic fever with renal syndrome (hfrs) were prepared from infected tissue culture fluids by ultracentrifugation. the titres of the precipitated antigens were increased considerably by acetone extraction and sonication. acetone extraction completely inactivated infectious virus in the antigen preparations. the antigens were ph-dependent, with ph optima at 5.8. good correlations were observed in human and rat s ...	1986	2868067
ribavirin therapy for hantaan virus infection in suckling mice.	we recently reported that ribavirin inhibited hantaan virus (hv) replication in vitro. in the present study, we used the hv suckling mouse model to evaluate the efficacy of treatment with various doses of ribavirin. beginning on day 10, untreated animals, infected with ten times the amount of hv (strain 76/118) required to kill 50% of the animals, lost weight; by days 15 to 18, they developed paralysis of both hind limbs, and they died between days 20 and 21. treatment with 50 mg of ribavirin/kg ...	1986	2869089
hantavirus nephropathy in western europe: ubiquity of hemorrhagic fevers with renal syndrome.		1986	2869650
pathogenesis of experimental hantaan virus infection in laboratory rats.	weanling fischer rats inoculated intramuscularly with hantaan virus (strain 76-118) developed subclinical infections characterized by transient viremia and shedding of virus in saliva, persistence of virus in lung, pancreas, spleen and liver, and development of fluorescent and neutralizing antibodies in serum with immune complex deposition in lung. viremia and virus shedding in saliva occurred 10 to 13 days after inoculation. horizontal intracage transmission of infection occurred between 35 and ...	1986	2869749
hantaan virus replication: effects of monensin, tunicamycin and endoglycosidases on the structural glycoproteins.	the monovalent ionophore monensin, which interferes with cellular transport pathways, and the antibiotic tunicamycin, which prevents glycosylation of newly synthesized proteins, were used to examine hantaan virus particle formation and polypeptide synthesis. viral replication in the presence of either drug resulted in reduced antigen production as well as reduced yields of both intracellular and extracellular infectious virus. analysis of viral polypeptides synthesized in the presence of the dru ...	1986	3083039
hemorrhagic fever with renal syndrome in czechoslovakia: detection of antigen in small terrestrial mammals and specific serum antibodies in man.	a direct elisa technique was used for demonstration of hfrs virus antigen in suspensions of the lungs obtained from 774 wild small mammals belonging to 13 zoological species trapped in 21 localities in czechoslovakia between 1983 and 1984. western serotype of hfrs virus was demonstrated in the lungs of 8 microtus arvalis voles caught in the areas of central bohemia, southern moravia and western slovakia, and in one clethrionomys glareolus vole from the area of eastern slovakia. the eastern serot ...	1986	3084630
[carriers of epidemic hemorrhagic fever virus in rodents and mites in ehf endemic area].		1986	3087624
[detection of antibodies to viruses causing hemorrhagic fever associated with a renal syndrome].		1986	3089543
[detection of antigens and antibodies of epidemic hemorrhagic fever virus in experimental albino rats in guangzhou city].		1986	3091256