Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [hantavirus: recent data and review of the literature]. | hantavirus (bunyaviridae family) are present worldwide and are the causative agent of haemorrhagic fever with renal or pulmonary syndrome. these viruses are transmitted by rodents with asymptomatic infection which thus act as an excellent reservoir. molecular epidemiology indicates that hantavirus may have evolved in three ways: mutations within the genome, reassortment of the segmented genome between two closely related hantavirus, and genomic recombination, a relatively rare phenomenon among n ... | 2000 | 11030053 |
| [detection for anti-hantavirus igm in patient serum with silver enhanced dot immunogold filtration assay]. | to establish a more rapid and simple method for detecting anti-hantavirus igm in patient' s serum. | 2000 | 11498694 |
| the incubation period of hantavirus pulmonary syndrome. | in 1993 sin nombre virus was recognized as the cause of hantavirus pulmonary syndrome (hps) and the deer mouse (peromyscus maniculatus) was identified as the reservoir host. surveillance by the centers for disease control and prevention and state health departments includes investigation to determine the likely site(s) and activities that led to infection, an environmental assessment of the home and workplace, and possibly rodent trappings at these sites. as of december 31, 1998, there were 200 ... | 2000 | 11304061 |
| [discovery of a new subtype of seo virus]. | the m and s segments of cou3, a hantavirus strain isolated from rattus norvegieus were partially reverse transcripted, pcr amplified and sequenced with abi 373 dna sequencer to observe the differences from other seo type viruses. | 2000 | 11471015 |
| [the partial nucleotide sequence of l segment of hantavirus strain]. | to study the nucleotide sequence of l segment of hantavirus strain a9. | 2000 | 11503036 |
| hantavirus update on an emerging--and lethal--infectious disease. | 2000 | 11503410 | |
| tracing dobrava hantavirus infection. | 2000 | 10837207 | |
| emerging infectious diseases: a cause for concern. | as the twenty-first century begins it becomes increasingly apparent that the twentieth century, which opened with the promise of the eradication of most infectious diseases, closed with the specter of the reemergence of many deadly infectious diseases that have a rapidly increasing incidence and geographic range. equally if not more alarming is the appearance of new infectious diseases that have become major sources of morbidity and mortality. among recent examples are hiv/aids, hantavirus pulmo ... | 2000 | 11344776 |
| [nephropathia epidemica and other hanta virus infections: how rodents' viruses cause disease in human?]. | 2000 | 11764460 | |
| hantavirus pulmonary syndrome in the americas: the early years. | the initial recognition of hantavirus pulmonary syndrome (hps) as a new disease associated with a cluster of acute respiratory deaths among american indians in the southwestern united states in 1993 bears little resemblance to the current understanding of this syndrome. hps is now recognized as a zoonotic disease that has been endemic throughout the americas for at least 40 years and that is closely linked to population densities and virus dynamics among a specific subfamily of rodents. the clas ... | 2000 | 16088742 |
| transmission of black creek canal virus between cotton rats. | black creek canal (bcc) virus is a hantavirus associated with hantavirus pulmonary syndrome in southeastern north america. the virus was isolated from the spleen of a cotton rat (sigmodon hispidus) trapped in southern florida. our previous studies have shown that we could consistently infect male cotton rats with bcc virus in the laboratory. these animals became persistently infected and virus could be detected in salivary glands, urine, and feces. in this report we show: (1) female and male cot ... | 2000 | 10568766 |
| hantavirus infection in taiwan: the experience of a geographically unique area. | hantaviruses are rodent-borne viruses, and they, mainly the hantaan (htn) serotype, are the causative agents of a group of febrile nephropathies known as "hemorrhagic fever with renal syndrome (hfrs). " despite the fact that hfrs is frequently reported in china, with an annual incidence of 50,000-100,000 cases, one puzzling observation that no local case of hfrs has been confirmed in taiwan has yet to be explained. we hypothesized that the hantavirus strain prevailing in taiwan mainly belongs to ... | 2000 | 10596027 |
| of mice, men, and microbes-hantavirus | 2000 | 10613808 | |
| accumulation of terminally deleted rnas may play a role in seoul virus persistence. | two independent, long-term infections were analyzed to determine whether changes in viral replication could contribute to the establishment and/or maintenance of persistent seoul virus infections. infected cell cultures initially contained high levels of infectious virus and intracellular viral rna that peaked between approximately 7 to 16 days postinfection and then gradually declined until day 26. after day 26, the viral titers and the levels of the small (s), medium (m), and large (l) viral r ... | 2000 | 10627543 |
| persistent hantavirus infections: characteristics and mechanisms. | hantaviruses include serious human pathogens that are maintained in nature in persistently infected rodents and that can also persistently infect cultured mammalian cells, causing little or no cytopathology. the mechanisms of hantavirus persistence are only beginning to be explored. recent data point to subtle changes in the viral genome that might result in the differential regulation of replication and lead to persistence. | 2000 | 10664598 |
| role of maternal antibody in natural infection of peromyscus maniculatus with sin nombre virus. | data from naturally infected deer mice (peromyscus maniculatus) were used to investigate vertical transmission of sin nombre virus (snv) and snv-specific antibody. the antibody prevalence in juvenile mice (14 g or less) was inversely proportional to the mass of the animal, with juvenile deer mice weighing less than 11 g most likely to be antibody positive (26.9%) and juvenile mice weighing between 13 and 14 g least likely to be antibody positive (12.9%). although a significant sex bias in seropo ... | 2000 | 10666274 |
| development and evaluation of a solid-phase enzyme immunoassay based on andes hantavirus recombinant nucleoprotein. | hantavirus pulmonary syndrome (hps) with high mortality rate has been reported in five countries in south america. rapid accurate methods are important both for monitoring acute infections and for epidemiological studies. the andes virus nucleoprotein amino acid sequence has a high identity percentage compared with other sequences of this region and has been chosen for the development of diagnostic reagents. andes nucleoprotein expressed in escherichia coli was applied as antigen in igg, iga and ... | 2000 | 10670565 |
| seroepidemiology of hantavirus in the philippines. | this study was undertaken to determine the seroepidemiology of hantavirus infection in the philippines. | 2000 | 10737848 |
| rodent-borne emerging viral zoonosis. hemorrhagic fevers and hantavirus infections in south america. | hantaviruses and arenaviruses are naturally occurring viruses of rodents. four south american hemorrhagic fevers caused by arenaviruses have emerged in the last 5 decades. all have similar clinical manifestations, with a case-fatality rate as high as 15% to 30%. hantavirus infections have been increasingly recognized in south america since the description in 1993 of hantavirus pulmonary syndrome. given the diversity of rodent species in the region, it can be foreseen that many other viruses will ... | 2000 | 10738678 |
| hantavirus pulmonary syndrome--panama, 1999-2000. | hantavirus pulmonary syndrome (hps) is an acute viral rodentborne zoonosis characterized by severe cardiopulmonary illness with a 40%-60% case-fatality rate. since its identification in the united states in 1993, the recognized clinical spectrum of illnesses associated with human hantavirus infection has expanded to include mild illness, and case-patients have been identified in canada and south america. this report describes the first confirmed hps cases from central america and summarizes prel ... | 2000 | 10738839 |
| [serologic study of the prevalence and course of hantavirus infections in mecklenburg-vorpommern]. | 694 sera obtained from 1994 till 1998 in the general population were examined with a recombinant enzyme immunoassay for hantavirus antibodies against the serotypes hantaan and puumala. positive samples were retested for confirmation with an indirect immunofluorescence assay and a recombinant immunoblot. the observed antibody prevalence of 0.9% signities that mecklenburg-vorpommern is not an endemic area. 12 out of 196 patients with a suspected hantavirus infection were confirmed. all proved anti ... | 2000 | 10740354 |
| hantavirus pulmonary syndrome in brazil: clinical aspects of three new cases. | hantavirus pulmonary syndrome (hps) has been recognized recently in brazil, where 28 cases have been reported as of september 1999. we report here the clinical and laboratory findings of three cases whose diagnoses were confirmed serologically. all the patients were adults who presented a febrile illness with respiratory symptoms that progressed to respiratory failure that required artificial ventilation in two of them. laboratory findings were most of the time consistent with those reported in ... | 2000 | 10742726 |
| pulmonary haemorrhage as a predominant cause of death in leptospirosis in seychelles. | we examined the cause of death during a 12-month period (1995/96) in all consecutive patients admitted to hospital with leptospiral infection in seychelles (indian ocean), where the disease is endemic. leptospirosis was diagnosed by use of the microscopic agglutination test and a specific polymerase chain reaction assay on serum samples. seventy-five cases were diagnosed and 6 patients died, a case fatality of 8%. all 6 patients died within 9 days of onset of symptoms and within 2 days of admiss ... | 2000 | 10748905 |
| sin nombre hantavirus disease in a ten-year-old boy and his mother. | 2000 | 10749469 | |
| [simultaneous leptospirosis and hantavirus infection in the same patient]. | the leptospirosis and the hantaviral infections are worldwide distributed zoonoses having the similar epidemiology and clinical symptoms. both in europe and asia those hantaviral serotypes are common which are responsible for the haemorrhagic fever with renal syndrome, while on the american continent the hantaviral pulmonary syndrome has also been diagnosed. authors describe a patient who had simultaneous leptospira and hantaviral infections with haemorrhagic fever as well as with mild, transien ... | 2000 | 10750403 |
| sin nombre virus (snv) ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome. | serum samples from 22 hantavirus pulmonary syndrome (hps) patients were tested for sin nombre virus (snv)-reactive antibodies. in the acute phase of hps, 100% and 67% of the samples tested positive for snv-specific immunoglobulin (ig) m and iga, respectively. among the virus-specific igg antibodies, the most prevalent were igg3 (in 97% of samples), followed by igg1 (70%), igg2 (30%), and igg4 (3%). | 2000 | 10756154 |
| serologic evidence of puumala virus infection in wild moose in northern sweden. | puumala (puu) virus is the causative agent of nephropathia epidemica, the scandinavian form of hemorrhagic fever with renal syndrome. the infection is acquired by airborne transmission of puu virus from its rodent reservoir, the bank vole. besides serologic data indicating that the virus may spread also to heterologous rodents, there is little information on the susceptibility of wild living animals to puu virus. we studied the occurrence of antibodies to puu virus in serum samples from 427 wild ... | 2000 | 10761733 |
| [clinical case of the month. a new case of nephropathia epidemica due to puumala virus]. | nephropathia epidemica due to puumala virus has already been described in belgium. its evolution is usually favourable. the main symptoms are fever, a decrease platelet count, proteinuria and acute renal insufficiency, which, in an epidemiological context, quickly point the correct diagnosis. acute and transitory myopia is typical. nevertheless, the clinical presentation, including multisystemic symptoms may lead to the false diagnosis of an acute bacterial or immune disease. | 2000 | 10769579 |
| annual update of systemic disease--1999: emerging and re-emerging infections (part ii). | 2000 | 10770510 | |
| spatial and temporal dynamics of puumala hantavirus infection in red bank vole (clethrionomys glareolus) populations in belgium. | dynamics of hantavirus infection and population densities in rodents were investigated from 1996 to 1999 in southern belgium. evidence of puumala infection was restricted to clethrionomys glareolus. although the serotype was not determined, antibodies against hantavirus were also found in eight apodemus sylvaticus. in fall 1996, the seroprevalence in c. glareolus was high (20.1%, 37 of 184) and the infection was widely distributed in the area studied whereas a focal occurrence of positive rodent ... | 2000 | 10773322 |
| epidemiology of community-acquired pneumonia in adults: a population-based study. | in this prospective study, the authors assessed the incidence, aetiology, and outcome of patients with community-acquired pneumonia in the general population. from december 1993 to november 1995, a study was performed in a mixed residential-industrial urban population of the "maresme" region in barcelona, spain. all subjects > or =14 yrs of age (annual average population size 74,368 inhabitants) with clinically suspected community-acquired pneumonia were registered. all cases were re-evaluated b ... | 2000 | 10780770 |
| genetic analysis of sin nombre hantavirus in iowa. | 2000 | 10783030 | |
| antigenic properties and diagnostic potential of recombinant dobrava virus nucleocapsid protein. | dobrava hantavirus (dobv) causes severe hemorrhagic fever with renal syndrome in the balkan region and has been detected recently also in russia, estonia, and germany. dobv nucleocapsid protein (n) was produced in insect cells, using the baculovirus expression system (bac-dobv-n), and in e. coli as a truncated (aa 1-165) glutathione-s transferase fusion protein (dobv-dn-gst). the antigenic properties of bac-dobv-n were found identical to native dobv-n when examined by a panel of hantavirus-speci ... | 2000 | 10797384 |
| [epidemiologic problems in hantavirus infections]. | the objective of the submitted paper was to present some information pertaining to epidemiological problems of hantavirus infection. in the czech republic the prevalence of these infections is not alarming but in the world cases of haemorrhagic fever with renal syndrome (hfrs) as well as hantavirus pulmonary syndrome (hps) are reported. on the territory of the czech republic there are foci of hantaviruses and in conjunction with summer tourism or working activities abroad the import of this infe ... | 2000 | 10802945 |
| from the centers for disease control and prevention. hantavirus pulmonary syndrome--panama, 1999-2000. | 2000 | 10807372 | |
| [acute renal failure in hantavirus infections]. | background: the acute renal failure remains a diagnostic challenge for the clinician. case reports: between 1991 and 1996, acute renal failure caused by hantavirus infection was diagnosed in 4 previously healthy male patients. main symptoms consisted of fever, headache, arthralgia, lumbar and abdominal pain as well as a decline in diuresis. the ultrasonography showed a slight splenomegaly in 2 patients. the clinical chemistry showed elevated serum creatinine from 2.2 mg/dl to 6.7 mg/dl and throm ... | 2000 | 10808304 |
| immunoglobulin a responses to puumala hantavirus. | puumala hantavirus (puuv) causes nephropathia epidemica (ne), a form of haemorrhagic fever with renal syndrome that occurs in northern and central europe. the immunoglobulin a (iga) response in ne patients was studied. the levels of total serum iga in acute-phase samples from ne patients were found to be significantly elevated when compared with the levels in healthy controls. elisas for detection of the iga1 and iga2 responses against each puuv structural protein (n, g1 and g2) were developed a ... | 2000 | 10811929 |
| outbreak of hantavirus infection in the four corners region of the united states in the wake of the 1997-1998 el nino-southern oscillation. | hantavirus cardiopulmonary syndrome (hcps), a rodent-borne zoonosis, has been endemic in the americas for at least several decades. it is hypothesized that the 1991-1992 el niño-southern oscillation (enso) caused increased precipitation that allowed an increase in rodent population densities, thereby increasing the possibility of transmission to humans. the result was a 1993-1994 outbreak of the disease in the four corners states of the southwestern united states. a second strong enso occurred i ... | 2000 | 10823755 |
| a case-control study after a hantavirus infection outbreak in the south of belgium: who is at risk? | puumala is the most common hantavirus serotype in europe and is spread mainly by the red bank vole. between 1 july 1992 and 31 january 1994, an outbreak of puumala virus-induced nephropathia epidemica (ne) occurred in the belgian ardennes. serologically confirmed cases (n = 41) were compared with two groups of asymptomatic seronegative controls. risks identified included sighting of living rodents, exposure to rodent droppings, and trapping rodents during the 4 weeks preceding onset of symptoms. ... | 1999 | 10825047 |
| hemorrhagic fever with renal syndrome in the dolenjska region of slovenia--a 10-year survey. | this report describes the first investigation of clinical findings for a larger series of patients with hemorrhagic fever with renal syndrome (hfrs) who were infected with dobrava virus. from 1985 to 1995, 38 patients with serologically confirmed hfrs were hospitalized at the regional hospital in novo mesto in the dolenjska region of slovenia. on the basis of results of serological examination, 24 patients had dobrava virus infection, and 14 patients had puumala virus infection. complete clinica ... | 1999 | 10825051 |
| superovulation in vesper mice, calomys laucha--an important biomedical model for hantavirus and arenavirus (rodentia-sigmodontinae). | sigmodontine rodents are poorly studied and have not received much attention as a reproductive model. renewed interest in the south american rodents has been stimulated by their link to endemic diseases that are transmitted to man. calomys laucha acts as a reservoir of two dangerous viruses: an arenavirus named 'junin virus', the aetiological agent of argentinian haemorrhagic fever, and the hantavirus, both of which constitute serious sanitary problems. the aim of this study was to establish sui ... | 1999 | 10778786 |
| hantavirus (bunyaviridae) infections in rodents from orange and san diego counties, california. | 1999 | 10674658 | |
| hantavirus infections in rodents | 1999 | 10674659 | |
| seroprevalence study of hantavirus infection in the community based population. | the genus hantavirus, family bunyaviridae, comprise at least 20 distinct viruses. ten of these have been linked to specific human diseases. hemorrhagic fever with renal syndrome has been recognized since the 1950s. hantavirus pulmonary syndrome was recognized in the united states in 1993. epizootiologic studies of norway rats in the baltimore area have shown that rodent infections with hantaviruses are common and geographically widespread with prevalence reaching 44% in tested rat populations. t ... | 1999 | 10628132 |
| rapidly evolving adult respiratory distress syndrome with eosinophilia of unknown cause in previously healthy active duty soldiers at an army training center: report of two cases. | two previously healthy soldiers presented with rapidly evolving adult respiratory distress syndrome (ards) within days of their return from the national training center at fort irwin, california. there have been six similar cases reported in the national training center area, five with fatal outcomes. | 1999 | 10628168 |
| newer pediatric pathogens. | newer laboratory techniques have allowed the detection of previously unrecognized microbial agents that are now pathogenic in children, as well as newly recognized manifestations of previously known pathogens. clinical reports of these newer agents or manifestations are reviewed so that pediatricians can become familiar with these emerging infectious diseases. physicians need to consider these organisms in the differential diagnosis in appropriate clinical illnesses. | 1999 | 10645465 |
| [hantavirus infections in belgium]. | hantavirus disease is a recently recognised zoonosis. the main vectors are infected but healthy wild rodents or laboratory rats. transmission to man occurs via contact with, or inhalation of aerosolised excretions. the target organs in man are the kidney (old world) or the lung (new world), probably via a local hyperproduction of pro-inflammatory cytokines. to date, more than 33 different hantaviruses have been characterised, at least 14 of them being of clinical importance. each serotype has it ... | 1999 | 10655777 |
| dynamics of puumala hantavirus infection in naturally infected bank voles (clethrinomys glareolus). | specific features of hantavirus infection in bank vole (clethrionomys glareolus) were studied in the endemic area of hemorrhagic fever with renal syndrome (hfrs) in the foothills of the ural mountains, using long-term observations on living animals by the capture-mark-recapture (cmr) method. the results demonstrated that the infection naturally circulating in the voles is chronic (lasting for up to 15 months) and asymptomatic, with a peak of puumala virus accumulation and release from the organi ... | 1999 | 10664394 |
| urban leptospirosis versus urban hantavirus infection in brazil. | 1999 | 10622333 | |
| chronic renal failure after puumala virus infection. | chronic renal failure has never been described after puumala hantavirus infection, which usually causes acute renal failure with spontaneous full recovery. we report a 15-year-old boy who presented with puumala hantavirus infection and initial severe acute renal failure. his renal function gradually improved, but more than 2 years after the acute episode it was still moderately impaired, with a creatinine clearance of about 60 ml/min per 1.73 m(2) | 1999 | 10603154 |
| hantavirus reservoir hosts associated with peridomestic habitats in argentina. | five species of sigmodontine rodents have been identified in argentina as the putative reservoirs of six circulating hantavirus genotypes. two species of oligoryzomys are associated with the genotypes causing hantavirus pulmonary syndrome, oligoryzomys flavescens for lechiguanas and o. longicaudatus for andes and oran genotypes. reports of human cases of hantavirus pulmonary syndrome prompted rodent trapping (2,299 rodents of 32 species during 27,780 trap nights) at potential exposure sites in t ... | 1999 | 10603213 |
| epidemiological study of nephropathia epidemica in finland 1989-96. | this study presents data on 33,000 serum samples studied from july 1989 to june 1996 in finland, with 6,701 serologically confirmed puumala virus (puu) infections. in addition, a puu serosurvey of 8,000 sera from finland is presented. on average, 957 puu infections were detected annually, resulting in an incidence of 19/100,000; mortality was less than 0.1%. the infection was most common in the district of ita-savo with an incidence of 90/100,000. the seasonal peak was in november-december; howe ... | 1999 | 10576121 |
| hantavirus infections: epidemiology and pathogenesis. | hantaviruses are enveloped rna viruses that persistently infect rodent hosts without ill-effect. the host persistently excretes virus in urine and saliva. man becomes infected from the rodents when one enters the ecological niche of the other. there are two major clinical presentations--haemorrhagic fever with renal syndrome, found worldwide in various forms and hantavirus pulmonary syndrome, found only in the americas. this review examines the virology, epidemiology and pathogenesis of these em ... | 1999 | 10580279 |
| hantavirus pulmonary syndrome in pregnancy. | this comprehensive case review of hantavirus pulmonary syndrome (hps) during pregnancy in 5 women characterizes the effect of sin nombre virus infection on maternal and fetal outcomes. histopathologic, serological, and clinical information were evaluated for evidence of vertical transmission. maternal ages ranged from 20 to 34 years and gestational ages from 13 to 29 weeks. symptoms, physical findings, and laboratory values other than those related to pregnancy were not noticeably different from ... | 1999 | 10585809 |
| absence of infection in a neonate after possible exposure to sin nombre hantavirus in breast milk. | 1999 | 10585821 | |
| absence of interhuman transmission of hantavirus pulmonary syndrome in minas gerais, brazil: evidence from a serological survey. | 1999 | 10585829 | |
| human memory cytotoxic t-lymphocyte (ctl) responses to hantaan virus infection: identification of virus-specific and cross-reactive cd8(+) ctl epitopes on nucleocapsid protein. | hantaan virus, the prototypic member of the hantavirus genus, causes hemorrhagic fever with renal syndrome in humans. we examined the human memory t-lymphocyte responses of three donors who had previous laboratory-acquired infections with hantaan virus. we demonstrated virus-specific responses in bulk cultures of peripheral blood mononuclear cells (pbmc) from all donors. bulk t-cell responses were directed against either hantaan virus nucleocapsid (n) or g1 protein, and these responses varied be ... | 1999 | 10364276 |
| isolation and characterization of a hantavirus from lemmus sibiricus: evidence for host switch during hantavirus evolution. | a novel hantavirus, first detected in siberian lemmings (lemmus sibiricus) collected near the topografov river in the taymyr peninsula, siberia (a. plyusnin et al., lancet 347:1835-1836, 1996), was isolated in vero e6 cells and in laboratory-bred norwegian lemmings (lemmus lemmus). the virus, named topografov virus (top), was most closely related to khabarovsk virus (kbr) and puumala viruses (puu). in a cross focus reduction neutralization test, anti-top lemmus antisera showed titers at least fo ... | 1999 | 10364307 |
| puumala virus infections in finland: increased occupational risk for farmers. | puumala hantavirus, transmitted by bank voles (clethrionomys glareolus), causes a mild-type hemorrhagic fever with renal syndrome. the disease is common in finland and is considered an occupational hazard for farmers, but the actual risk has not been assessed by analytical studies. data on 5,132 serologically confirmed puumala virus infections during 1989-1994 were analyzed, and cases among farmers and the population living in similar conditions were compared. the farmers contracted the disease ... | 1999 | 10369509 |
| [an outdoor person with high fever and flank pain]. | 1999 | 10380593 | |
| risk factors for human hantavirus infection: franco-belgian collaborative case-control study during 1995-6 epidemic. | 1999 | 10381709 | |
| rodent control may help prevent human hantavirus infection | 1999 | 10381750 | |
| hantavirus in the americas. | 1999 | 10382376 | |
| update: hantavirus pulmonary syndrome--united states, 1999. | hantavirus pulmonary syndrome (hps) is a rodentborne viral disease characterized by severe pulmonary illness and a case-fatality ratio of 43%. sin nombre virus is the primary hantavirus that causes hps in the united states, and the deer mouse (peromyscus maniculatus) is its predominant carrier. cdc-sponsored studies of rodent populations since 1994 have yielded data that suggest an increased risk for infection for humans in some areas of the southwestern united states during the summer of 1999. ... | 1999 | 10401910 |
| [increased travelling--increased risk of imported viruses. a review of the diagnostic capacity of the swedish institute for infectious disease control]. | the increase in global travel, especially by air, has facilitated the spread of infectious agents from one part of the world to another. returning travellers are often vectors for viral disease import to sweden. while dengue fever has been quite frequently diagnosed during the past five years, especially in travellers returning from thailand, only isolated cases of sandfly fever, japanese encephalitis and ross river fever have been seen. dobrava virus was recently shown to have caused a severe f ... | 1999 | 10405531 |
| hantavirus pulmonary syndrome (hps) in guariba, sp, brazil. report of 2 cases. | human infections caused by a hantavirus were reported in different regions of the state of são paulo (sp), brazil during the first six months of 1998. two cases of fatal pulmonary syndrome occurred in may of 1998 in the city of guariba, located in the northeastern region of sp. both patients worked in a corn storage barn infested by rodents. these patients, after 2 or 3 days of non-specific febrile illness, developed a severe interstitial pneumonia spreading widely in both lungs, causing respira ... | 1999 | 10413962 |
| antibody responses in humans to an inactivated hantavirus vaccine (hantavax). | hantaviruses cause haemorrhagic fever with renal syndrome (hfrs) and result in severe human morbidity and mortality. safe and effective vaccines are needed urgently in order to reduce the incidence of human illness. hitherto studies of hantavirus vaccine efficiency have been limited to individuals at low risk of infection. in this study the immune response to an inactivated hantavirus vaccine was measured in 64 human volunteers at high risk of infection by virtue of residence and occupation. 30 ... | 1999 | 10418904 |
| isolation and genetic characterization of a hantavirus (bunyaviridae: hantavirus) from a rodent, oligoryzomys microtis (muridae), collected in northeastern peru. | this paper describes the isolation and partial genetic characterization of a hantavirus from a pygmy rice rat, oligoryzomys microtis, collected within the urban area of iquitos, loreto department, peru. the virus, designated htn-007, exhibited the highest degree of genetic similarity to rio mamore virus, which was originally described from the same rodent species in eastern bolivia. comparison of small and medium segment nucleotide sequence data from htn-007 and rio mamore virus revealed 87% and ... | 1999 | 10432063 |
| [hantavirus pulmonary syndrome in southern chile]. | 1999 | 10436725 | |
| intramuscular inoculation of sin nombre hantavirus cdnas induces cellular and humoral immune responses in balb/c mice. | to examine whether genetic immunization with sin nombre (sn) hantavirus genes could elicit immune responses, nine fragments spanning the envelope glycoprotein genes g1 and g2, and the complete n gene were cloned into a cmv expression vector. to ensure representation of all potential epitopes, adjacent fragments of the glycoprotein genes overlapped one another by 100 nucleotides. vectors containing the gene fragments were inoculated intramuscularly into balb/c mice and splenocyte proliferation an ... | 1999 | 10438054 |
| a major outbreak of hantavirus infection in belgium in 1995 and 1996. | haemorrhagic fever with renal syndrome (hfrs) is a human disease characterized by flu-like symptoms, renal dysfunction, and in severe cases, haemorrhagic manifestations. the causative agents of hfrs are hantaan (htn), seoul (seo), puumala (puu) and dobrava (dob) hantaviruses. hantavirus infections are of increasing importance in europe. outbreaks occur in belgium with a 3- to 4-year interval with an increasing number of cases. we describe the largest outbreak so far in belgium with 217 serologic ... | 1999 | 10459649 |
| hantavirus infection--haemorrhagic fever in the balkans--potential nephrological hazards in the kosovo war. | 1999 | 10462258 | |
| dobrava virus infection: serological diagnosis and cross-reactions to other hantaviruses. | recent data have shown that dobrava (dob) hantavirus is the cause of severe haemorrhagic fever with renal syndrome (hfrs) in central and eastern europe. to determine whether serological assays need to be based on the homologous viral antigen rather than on closely related hantavirus antigens, acute and convalescent sera from patients with hfrs collected in former yugoslavia were examined for igm and igg to three hantavirus antigens; dob, hantaan (htn) and puumala (puu). focus reduction neutraliz ... | 1999 | 10471023 |
| a new clethrionomys-derived hantavirus from germany: evidence for distinct genetic sublineages of puumala viruses in western europe. | puumala (puu) viruses are the predominant etiologic agents of hantavirus infections in europe. the most important reservoir is the bank vole, clethrionomys glareolus (cg), belonging to the subfamily arvicolinae of the muridae family. here we report on the molecular characterization of the first rodent-derived sequence (puu/cg-erft) from germany. comparison of the s and m segment coding regions revealed 92.5 and 92.8% identity, respectively, with puu/h-9013, a human isolate from france. however, ... | 1999 | 10475080 |
| nephropathia epidemica and puumala virus in austria. | to study the epidemiology of hantavirus infections in austria, 1215 humans and 596 rodents of different species were tested for the presence of antibodies against puumala and hantaan virus. direct virus identification by polymerase chain reaction in lung tissue of serologically positive rodents was performed to verify antibody results and to determine the genetic identity of viral rna by phylogenetic analysis of a part of the hantavirus m segment. for 32 of the 37 cases of nephropathia epidemica ... | 1999 | 10482022 |
| new chimaeric hepatitis b virus core particles carrying hantavirus (serotype puumala) epitopes: immunogenicity and protection against virus challenge. | virus-like particles generated by the heterologous expression of virus structural proteins are able to potentiate the immunogenicity of foreign epitopes presented on their surface. in recent years epitopes of various origin have been inserted into the core antigen of hepatitis b virus (hbv) allowing the formation of chimaeric hbv core particles. chimaeric core particles carrying the 45 n-terminal amino acids of the puumala hantavirus nucleocapsid protein induced protective immunity in bank voles ... | 1999 | 10486924 |
| low ph-induced cytopathic effect--a survey of seven hantavirus strains. | hantaviruses do not produce cytopathic effects (cpe) in cell culture. however, a syncytial cpe can be induced in 7-day cultures of hantavirus growing in vero e6 cells by reduction of the ph to approximately 6.2 using a hepes based buffer. the appearance of this acid induced cpe was examined for seven different hantavirus strains. the differences noted were striking and reflected the taxonomic differences between hantaviruses. at 10-100 tcid50% the size of syncytial foci was very large for seoul ... | 1999 | 10488778 |
| acute polyarthritis associated with hantavirus infection. | 1999 | 10489233 | |
| short report: simultaneous occurrence of dobrava, puumala, and tula hantaviruses in slovakia. | the prevalence of antibody to hantaviruses in slovakia (serum panel n = 2,133) was lower in the western part (0.54%) and higher in the eastern part (1.91%) of the country and was found to be significantly enhanced in a group of forest workers from eastern slovakia (5.88%). one-third of the igm-negative convalescent phase sera from patients with hemorrhagic fever with renal syndrome exhibited antibodies reacting predominantly with puumala virus antigen, while two-thirds had antibodies directed ma ... | 1999 | 10497981 |
| [functional activity of hemagglutinins from hantaan viruses strains and use of hemagglutinating antigens for serodiagnosis hemorrhagic fever with kidney syndrome]. | hemagglutinins of hantaan virus strains isolated in southern far east of russia from patients with hemorrhagic fever with the renal syndrome and from rodents, natural vectors of the virus, were studied in the cross kinetic hemagglutination inhibition test with immune sera to the studied strains. the strains differed by the functional activity index. use of hemagglutinins of functionally active hantaan strains in serologic studies notably improves the diagnostic efficacy of the hemagglutination t ... | 1999 | 10500991 |
| analysis of puumala hantavirus genome in patients with nephropathia epidemica and rodent carriers from the sites of infection. | reverse transcription-polymerase chain reaction (rt-pcr) followed by sequence and phylogenetic analyses were used to study specimens from nine finnish nephropathia epidemica (ne) patients admitted to hospital during the epidemic in winter 1996-1997. blood samples from six patients were found to be positive for the partial m- and/or s-segment sequences of puumala hantavirus (puuv). analyses of these sequences (nt 2168-2610 for the m segment, and nt 819-1082 for the s segment) revealed six distinc ... | 1999 | 10502274 |
| phage-displayed peptides mimicking the discontinuous neutralization sites of puumala hantavirus envelope glycoproteins. | we selected peptide ligands mimicking the surface structure of discontinuous binding sites of puumala hantavirus-neutralizing monoclonal antibodies from a random 18-amino acid peptide library containing a disulfide bridge in a fixed position and displayed on a filamentous phage. the varying of selection conditions, either by shortening of the association time or by competitive elution with antigen, was crucial for the selection of peptide inserts that could be aligned with the primary sequences ... | 1999 | 10502511 |
| update: hantavirus pulmonary syndrome--united states, 1999. | 1999 | 10510528 | |
| acute sin nombre hantavirus infection without pulmonary syndrome, united states. | hantavirus pulmonary syndrome (hps) occurs in most infections with sin nombre virus and other north american hantaviruses. we report five cases of acute hantavirus infection that did not fit the hps case definition. the patients had characteristic prodromal symptoms without severe pulmonary involvement. these cases suggest that surveillance for hps may need to be expanded. | 1999 | 10511527 |
| temporal and spatial analysis of sin nombre virus quasispecies in naturally infected rodents. | sin nombre virus (snv) is thought to establish a persistent infection in its natural reservoir, the deer mouse (peromyscus maniculatus), despite a strong host immune response. snv-specific neutralizing antibodies were routinely detected in deer mice which maintained virus rna in the blood and lungs. to determine whether viral diversity played a role in snv persistence and immune escape in deer mice, we measured the prevalence of virus quasispecies in infected rodents over time in a natural setti ... | 1999 | 10516063 |
| acute infection with sin nombre hantavirus without pulmonary edema. | acute infection with sin nombre virus has been associated with development of hantavirus cardiopulmonary syndrome (hcps), a severe cardiopulmonary illness with respiratory failure and shock. we present two cases of sin nombre hantavirus infections that did not lead to marked pulmonary complications in two otherwise healthy young adults from utah and california. sin nombre virus causes a wider spectrum of disease severity than has been previously reported. | 1999 | 10530462 |
| genetic investigation of novel hantaviruses causing fatal hps in brazil. | although hantavirus pulmonary syndrome (hps) was discovered in north america in 1993, more recent investigations have shown that the disease is a much larger problem in south america, where a greater number of cases and hps-associated viruses have now been detected. here we describe the genetic investigation of three fatal hps cases from brazil, including a 1995 case in castelo dos sonhos (cas) in the state of mato grosso and two 1996 cases in the counties of araraquara (ara) and franca (fra), i ... | 1999 | 10534737 |
| n-acetylgalactosamine (galnac)-specific lectins mediate enhancement of hantaan virus infection. | summary. n-acetylgalactosamine (galnac)-specific lectins, dolichos biflorus agglutinin (dba), and soybean agglutinin (sba), enhanced hantaan (htn) virus infections in vero e6 and p388d1 cells. treatment of vero e6 cells with the lectins either before or during, but not after, virus inoculation resulted in lectin-mediated enhancement of infection (lme), indicating that galnac-specific lectin affects an early stage of the infection. lectin blot and facs analysis showed that the ability of htn viru ... | 1999 | 10542025 |
| comparison of the protective efficacy of naked dna, dna-based sindbis replicon, and packaged sindbis replicon vectors expressing hantavirus structural genes in hamsters. | seoul virus (seov) is a member of the hantavirus genus (family bunyaviridae) and an etiological agent of hemorrhagic fever with renal syndrome. the medium (m) and small (s) gene segments of seov encode the viral envelope glycoproteins and nucleocapsid protein, respectively. we compared the immunogenicity and protective efficacy of naked dna (pwrg7077), dna-based sindbis replicon (psin2.5), and packaged sindbis replicon vectors (psinrep5), containing either the m or s gene segment of seov in syri ... | 1999 | 10544095 |
| apoptosis is induced by hantaviruses in cultured cells. | hantaviruses replicate in primary and cultured animal cells with little or no cytopathic effect. we report here that the cultured vero e6 cells infected by the hantaan or by the prospect hill viruses exhibited characteristic features of apoptosis, including condensation and segmentation of nuclei and internucleosomal cleavage of nuclear dna. apoptosis was not seen in the cells adsorbed by uv-inactivated virus, indicating that the viral replication is required for the induction of apoptosis. furt ... | 1999 | 10544134 |
| [circulation of seoul hantavirus in populations of synanthropic rodents and its significance in the incidence of hemorrhagic fever with renal syndrome in the primorye territory]. | the prevalence of seoul virus in the primorie territory is presented and its significance in the morbidity structure with regard to hemorrhagic fever with the renal syndrome (hlps) is discussed. epidemiological and clinical manifestations of hlps caused by seoul virus are described. the authors conclude that in the urban foci of hlps it is associated mainly with seoul virus, while in the rural foci, with hantaan virus. | 1999 | 10544448 |
| high levels of viremia in patients with the hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome (hps) is a rare but acute fulminant disease caused by sin nombre virus (snv). to understand the role of the viral load in the pathogenesis of hps, the load of virus in the blood of patients with hps was measured. a quantitative reverse transcription-polymerase chain reaction assay was developed for snv, because snv is difficult to grow in cell culture. thirty-eight samples from 26 patients with hps were analyzed. twenty of the 26 initial samples were positive for vi ... | 1999 | 10558964 |
| characterization of the hantaan nucleocapsid protein-ribonucleic acid interaction. | the nucleocapsid (n) protein functions in hantavirus replication through its interactions with the viral genomic and antigenomic rnas. to address the biological functions of the n protein, it was critical to first define this binding interaction. the dissociation constant, k(d), for the interaction of the hantaan virus (htnv) n protein and its genomic s segment (vrna) was measured under several solution conditions. overall, increasing the nacl and mg(2+) in these binding reactions had little imp ... | 1999 | 10559265 |
| sin nombre virus pathogenesis in peromyscus maniculatus. | sin nombre virus (snv), a member of the hantavirus genus, causes acute viral pneumonia in humans and is thought to persistently infect mice. the deer mouse, peromyscus maniculatus, has been identified as the primary reservoir host for snv. to understand snv infection of p. maniculatus, we examined wild deer mice for localization of viral antigens and nucleic acid. morphologic examination consistently revealed septal edema within lung tissue and mononuclear cell infiltrates in portal areas of the ... | 1999 | 9847363 |
| recombination in tula hantavirus evolution: analysis of genetic lineages from slovakia. | to examine the evolution of tula hantavirus (tul), carried by the european common vole (microtus arvalis and m. rossiaemeridionalis), we have analyzed genetic variants from slovakia, the country where the virus is endemic. phylogenetic analysis (phylip) based on either partial (nucleotides [nt] 441 to 898) or complete n-protein-encoding sequences divided slovakian tul variants into two main lineages: (i) strains from eastern slovakia, which clustered with russian strains, and (ii) strains from w ... | 1999 | 9847372 |
| new york 1 and sin nombre viruses are serotypically distinct viruses associated with hantavirus pulmonary syndrome. | new york 1 virus (ny-1) and sin nombre virus (sn) are associated with hantavirus pulmonary syndrome (hps). ny-1 and sn are derived from unique mammalian hosts and geographic locations but have similar g1 and g2 surface proteins (93 and 97% identical, respectively). focus reduction neutralization assays were used to define the serotypic relationship between ny-1 and sn. sera from ny-1-positive peromyscus leucopus neutralized ny-1 and sn at titers of >/=1/3,200 and </=1/400, respectively (n = 12). ... | 1999 | 9854075 |
| high levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome (hps) is characterized by the rapid onset of pulmonary edema and a high case-fatality rate. hantavirus antigens have been demonstrated in pulmonary capillary endothelial cells, but the mechanisms causing capillary leakage remain unclear. immunohistochemical staining was used to enumerate cytokine-producing cells (monokines: interleukin [il]-1alpha, il-1beta, il-6, and tumor necrosis factor [tnf]-alpha; lymphokines: interferon-gamma, il-2, il-4, and tnf-beta) in tiss ... | 1999 | 9878011 |
| ["emerging" viral zoonoses in native animals who can be the host in the netherlands]. | viral zoonotic diseases can be defined as 'viral diseases transmitted from vertebrate animals to man'. viral zoonoses have been emerging and re-emerging throughout history and can cause serious diseases and disease outbreaks in human populations. this paper deals with emerging viral zoonotic infections that have hosts in native species and can be a hazard for the human population in the netherlands. rabies virus, hantavirus, influenza virus tick-borne encephalitis virus, borna disease virus and ... | 1999 | 9921612 |
| dobrava hantavirus in russia. | 1999 | 9923881 | |
| hantavirus (bunyaviridae) infections in rodents from orange and san diego counties, california. | during a screening program to determine the extent of hantavirus activity in orange and san diego counties, california, serum samples from 2,365 rodents representing nine genera and 15 species were tested for hantavirus antibodies. a reverse transcription-polymerase chain reaction on selected seropositive rodents was used to identify the specific hantavirus. rodents positive for sin nombre virus (snv) antibodies by western blot included 86 (9.1%) of 948 deer mice (peromyscus maniculatus), four ( ... | 1999 | 9988327 |