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[qualitative studies on the effect of antibodies against influenza virus a and b in mothers and infants to 6 months of age]. 195014792596
neutralization and hemagglutination inhibition of swine influenza virus by serum from suckling swine and by milk from their dams. 195014794899
the influence of acth on the course of experimental influenza virus type a infections. 195014795034
[antibodies of influenza a and b in mothers and children examined 6 months following birth]. 195014815372
an antigenically distinct subtype of influenza virus a which is virulent for mice in primary passage of allantoic fluid. 195014787447
influenza : ii. effect of influenza virus multiplication on the oxygen consumption curves of embryonated eggs incubated at different temperatures.in addition to the cycles of growth shown by the influenza a virus during the first 24 hours of its residence in the fertile egg, cycles separated by longer time intervals have been noted between the 24th and 96th hours. these longer cycles are best seen when the eggs are incubated at 40 degrees c. corresponding fairly accurately with these cycles of growth of the virus, wide cyclic variations in the rates of increase in oxygen consumption of the infected eggs have been found to occur. these var ...195019871709
influenza : iii. rapid alterations in the respiratory rate of embryonated eggs apparently caused by influenza virus toxin.allantoic fluid from embryonated eggs infected with influenza a virus contains a toxic agent which can be demonstrated and quantitatively measured by its rapid effect on oxygen consumption when it is introduced in new series of fertile eggs. the effects were measured 90 minutes after the injection of the infected fluid, and were seen following both intra-allantoic injection and injection into the yolk sac. this toxin, in concentrations resulting from the injection of 0.5 cc. or less of the infec ...195019871710
influenza : i. the hemagglutination and infectivity titre curves of pr8 influenza virus cultivated in embryonated eggs at different temperatures.groups of embryonated eggs infected with the pr8 strain of influenza virus a were incubated at 34 degrees , 37.5 degrees , and 40 degrees c. at frequent intervals, for periods ranging up to 96 hours, pooled allantoic fluids were tested simultaneously for infectivity and hemagglutination. after about 12 hours of virus growth, fluids often showed infectivity titres greater than 10(-5), but were incapable of causing hemagglutination. at later time intervals, marked disagreement between the two test ...195019871708
the uptake of radioactive phosphorus by influenza virus a (pr8 strain). 195024537515
[metabolic disorders in influenza (influenza-a epidemics in basel, winter 1948/49)]. 195015409965
[curve of antibodies in normal and in subjects with influenza a and b during the peak of the epidemic of 1948-1949]. 195014815374
antigenic pattern of strains of influenza a and b. 195014808422
the chemical analysis of purified influenza virus a (pr8 strain) containing radioactive phosphorus. 195024538859
[epidemic of influenza a and b in a community]. 195114921672
immunity to old and new strains of influenza a virus. 195114848539
[modifications in the vegetative nervous system in virus influenza a]. 195114881381
spontaneous mutation of influenza virus a during routine egg passage. 195114886504
propagation of the pr8 strain of influenza a virus in chick embryos. iii. properties of the incomplete virus produced in serial passages of undiluted virus. 195114902470
a genetic approach to variation in influenza viruses; the characters of three substrains of influenza virus a (ws). 195114824469
a genetic approach to variation in influenza viruses; recombination of characters between the influenza virus a strain nws and strains of different serological subtypes. 195114824472
the influence of acth on the course of experimental influenza type a virus infection. 195114824670
adrenocorticotrophic hormone (acth) in the treatment of experimental air-borne influenza virus type a infection in the ferret. 195114824691
the incidence of haemagglutination inhibiting antibodies for influenza a and b virus strains in sera of children and infants. 195114830168
effect of swine influenza virus on a sulphonphthalein dye. 195114806522
immunization with influenza virus a vaccines. comparison of intradermal and subcutaneous routes. 195114842090
propagation of the pr8 strain on influenza a virus in chick embryos. i the influence of various experimental conditions on virus multiplication. 195114856731
propagation of the pr8 strain of influenza a virus in chick embryos. ii. the formation of incomplete virus following inoculation of large doses of seed virus. 195114856732
destruction and denaturation of influenza a virus. 195114857767
mechanism of production of pulmonary lesions in mice by newcastle disease virus (ndv).infectious ndv particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. the lesions are indistinguishable from those of influenza a virus infection. this effect of ndv was blocked by intranasal injection of rde or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after ndv. influenza a virus infection did not diminish fixation of ndv in excised lungs but did interfere with the injurious action of ...195114861378
[persistent antigenic variations of influenza a virus after incomplete neutralization in ovo with heterologous immune serum]. 195114930276
[effect of influenza a virus on the normal cell and neoplastic cell in vitro]. 195114930473
[modifications of the nervous system in virus influenza a and b]. 195114863545
studies on host-virus interactions in the chick embryo-influenza virus system. v. simultaneous serial passage of the agents of influenza a and b in relation to variations in the growth cycle of influenza b virus.the combined passage of influenza a and b viruses in series, as reported by sugg and magill, has been confirmed. when the mixed passage materials were not too highly diluted both agents could be traced through 10 transfers. growth curve experiments revealed that both agents developed independently, as measured by hemagglutination-inhibition tests in the presence of specific immune sera against one or the other type. however, the hemagglutinin titers of the 2 viruses in the mixed series were alwa ...195114888813
concurrent infection with influenza a and b viruses in a single epidemic of influenza. 195114908078
recombinant viruses obtained from double infections with the influenza a viruses mel and neuro-ws. 195114895467
preparation of a stable non-infective soluble influenza a antigen. 195114827916
the isolation and properties of a modified strain of neurotropic influenza a virus. 195214935093
observations with the electron microscope on cells of the chick chorio-allantoic membrane infected with influenza virus.preparations of influenza-infected chick chorio-allantoic membrane made by two types of tissue culture and by sectioning, have been studied in the electron microscope. comparisons have been made of influenza a' (fm1), influenza a (pr8), and swine influenza (v15), three strains which produce different relative numbers of filaments. normal surface projections which may be confused with influenza filaments are described. extruded products of degenerating cells, usually bleb-shaped, may also be foun ...195214927791
propagation of the pr8 strain of influenza a virus in chick embryos. iv. studies on the factors involved in the formation of incomplete virus upon serial passage of undiluted virus. 195214933064
quantitative aspects of the multiplication of influenza a virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia.influenza a virus, pr8 strain, increases in amount in the infected mouse lung at a relatively constant rate. when more than 25 m.s.50 doses of virus is inoculated, the rate of multiplication appears to be independent of the amount of virus introduced; has a value of 1,100-fold increase per day. the rate of increase in the pulmonary lesions induced by infection of the mouse lung with pr8 also appears to be relatively constant and independent of the amount of virus inoculated; has a value of 8.5-f ...195214907966
the effect of total body x irradiation on the susceptibility of mice to influenza a virus infection. 195214938539
preparation of stable noninfective soluble influenza a antigen. ii. use of various reagents for neutralization of formaldehyde-treated antigens. 195214945011
further studies on antigenic variation of influenza a virus. 195214949001
the action of plant extracts on a bacteriophage of pseudomonas pyocyanea and on influenza a virus. 195214927853
[effect of influenza virus a on normal and neoplastic cells cultivated in vitro]. 195212998183
[reactions with kaolin, swine influenza virus and albumen inhibitor of virus hemagglutination]. 195213012848
antigenic similarity between the first and later egg passage strains of freshly recovered influenza a viruses. 195213047324
effect of sodium monofluoroacetate on the multiplication of influenza viruses, mumps virus and pneumonia virus of mice (pvm).sodium fluoroacetate, given after virus inoculation in doses of 3 to 4 mg. per kg. in mice or 2 mg. in chick embryos, caused only a slight delay in the multiplication of the pr8 strain of influenza a virus in the mouse lung and of pr8 or the lee strain of influenza b virus in the allantoic sac. the quantities of the compound used were sufficient to cause approximately 10 to 20 per cent mortality in mice and 100 per cent in chick embryos. the use of small virus inocula did not markedly increase t ...195213022848
[research on experimental teratology of the auditory organ; experience with influenza a and b virus]. 195213042967
[action of influenza a virus on sulfhydryl groups]. 195213048061
[determination of cations and phosphates in allantois infected with influenza a virus; variations of potassemia]. 195213048062
comparison of the antigenic patterns of influenza a virus strains determined by in ovo neutralization and hemagglutination-inhibition. 195213000145
strain-specific elements in influenza antigens.rabbit antisera were prepared against ten antigenically different influenza a strains. these sera were absorbed with one or more heterologous strains and in each case all the heterologous or crossing antibody was removed; the anti-bodies remaining after this treatment were specific for the immunizing strain or group of strains. on the basis of reactions with absorbed sera, the strains fell into seven groups. absorbed specific antisera of these groups were used to test the hi titer against a larg ...195213022853
virus influenza a infection with pulmonary manifestations. 195214943299
evaluation of monovalent influenza vaccines. ii. observations during an influenza a-prime epidemic. 195214885162
influenza a viruses; laboratory studies, with special reference to european outbreak of 1950-1. 195212988024
genetic interaction and interference between the mel and nws strains of influenza a virus. 195313059249
neutralization of viruses by homologous immune serum. i. quantitative studies on factors which affect the neutralization reaction with newcastle disease, influenza a, and bacterial virus t3.neutralization experiments with newcastle disease, influenza a, or bacterial virus, t(3), reveal, under all conditions studied, a linear relationship between the logarithm of the serum dilution end point and that of the quantity of virus used. with newcastle disease and influenza a, the slope of the neutralization line varies markedly with the host-cell system used and in the chick embryo is strikingly affected by the route of inoculation. the other variables examined have no definite effect upo ...195313069640
studies on host-virus interactions in the chick embryo-influenza virus system. vii. data concerning the significance of infectivity titration end-points and the separation of clones at limiting dilutions.equal mixtures of influenza a (pr8) and b (lee) viruses, based on predetermined id(50) values of the individual preparations, were titrated in closely spaced steps near the 50 per cent infectivity end-point. typing of the hemagglutinins found in the allantoic fluids after incubation of the eggs for 72 hours showed an approximately equal distribution between types a and b, when less than 2 id(50) of the mixed seed had been injected. with larger inocula influenza a became dominant because it repro ...195313069643
an antiviral substance from penicillium funiculosum. i. effect upon infection in mice with swine influenza virus and columbia sk encephalomyelitis virus.a culture of p. funiculosum isolated on guam proved capable of elaborating a substance which exerted a favorable therapeutic effect against swine influenza virus infections in white mice. the culture was extremely variable and irregular in its production of the antiviral substance, and during maintenance in the laboratory for several years gradually lost this property. efforts to restore it were unsuccessful. subsequently it was found that the mold elaborated a substance, now designated helenine ...195313052822
production of influenza a virus in the cells of the allantois. 195313069724
antigenic relationships of swine influenza virus. 195313084886
epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus.the effects on the antibody content of the population which result from repeated exposure to antigenic variants of influenza viruses have been studied by measuring, with many strains, the antibody content of lots of gamma globulin prepared in different years and the patterns of antibody found in sera collected in 1 year from various age groups. in all samples of gamma globulin collected from 1943 through 1951, high levels of antibody were found with strains of type a and type b influenza viruses ...195313109114
influenza antibodies in the population of the usa; an epidemiological investigation.sera taken from persons of various ages in 1951 and collected from adults yearly from 1943 to 1951, inclusive, were tested by the haemagglutination-inhibition method with influenza viruses selected to represent the subgroups of each antigenic type. these were influenza a-ws (1933) and pr8 (1934); influenza a-prime-fm1 (1947) and fw-1-50 (1950); influenza b-lee (1940) and ib1 (1950); influenza c-1233 (1947). the sera tested with influenza a and b viruses were treated with cholera filtrate to remo ...195313094497
[studies on biological and antigenic properties of certain strains of influenza virus a]. 195313205672
the experimental production of combination forms of virus. i. occurrence of combination forms after simultaneous inoculation of the allantoic sac with two distinct strains of influenza virus.the fact that the hemagglutination inhibition test will not detect more than one component in an artificial mixture of two antigenically distinct strains of virus was demonstrated experimentally. with this proved, the inference seemed justified that the inhibition of the hemagglutinin of a virus suspension by each of two antisera, specific for differing strains of virus, would be an indication that some of the specific antigenic components from each of these viruses were both present in single p ...195313069649
studies on the variation of influenza a virus in nature; the significance of isolation since 1946 of strains antigenically related to ws or pr8. 195313158145
prenatal and early postnatal survival in the mouse as affected by infection of the mother with swine influenza virus during gestation. 195313118162
effect of 2,4-dinitrophenol and sodium azide on host cell metabolism and influenza a virus. 195313092960
the effect of x-radiation on the multiplication of influenza a virus in embryonate eggs.groups of embryonate eggs were given 250, 500, 750, and 1000 r of x-radiation. 18 hours later, these 4 groups, together with a control group, were injected intra-allantoically with influenza a virus. radiation at all dosage levels caused significant changes in the infectivity titre curves during the next 90 hours. the most striking alterations were the prolonged incubation period and the uniformly low infectivity titre in the group of eggs given 750 r.195313022868
influenza a in early pregnancy. 195313046639
influenza a and congenital anomalies. 195313046642
air-borne influenza virus a infections in immunized animals. 195313136266
the experimental production of combination forms of virus. ii. a study of serial passage in the allantoic sac of agents that combine the antigens of two distinct influenza a strains.double infection of the allantoic sac with melbourne and wsn viruses induced the formation of a combination virus, which had some of the antigenic properties of both parents and which maintained itself through serial passage in the chorioallantoic sac. in the course of prolonged passage in the egg, three varieties of combination virus were found. the first (x(1)) occurred in ten passages and was characterized as follows: x(1) was produced in and could be successfully passed from those chick embr ...195313069650
in vitro action of sulfur mustard and chloroethylamine derivatives upon antigenicity of influenza a (pr8) virus. 195313035093
in vitro action of mustards on the infective and toxic components of influenza a (pr8) virus. 195313035092
virus growth in tissue culture fibroblasts. i. influenza a and herpes simplex viruses. 195313035088
influenza a prime. 195313090304
back-recombination of influenza a strains obtained in recombination experiments. 195313093557
action of mustards on interfering, hemagglutinating and eluting capacities of influenza a (pr8) virus. 195313069722
inhibition of influenza virus multiplication by n-glycosides of benzimidazoles-n.chloro derivatives of benzimidazole were found to be 2 to 3 times more active than corresponding methyl derivatives in causing inhibition of lee virus multiplication in chorioallantoic membrane cultures in vitro. the most active benzimidazole derivative thus far tested is 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (drb); it caused 75 per cent inhibition of lee virus multiplication in membrane cultures at a concentration of 0.38 x 10(-4)m. on the other hand, 5,6-dimethyl-1-alpha;-d-ribofura ...195413130796
disruption of influenza virus; properties of degradation products of the virus particle.1. the hemagglutinating capacity, enzymic activity, and infectivity of several influenza viruses were destroyed by repeated freezing and thawing of dialyzed allantoic fluids containing them. 2. influenza virus degraded by freezing and thawing, by treatment with 5 m urea, or by heating at 65 degrees c. still combined with homologous antibody and was demonstrable by blocking of the hemagglutination-inhibition and virus neutralization reactions. 3. after 50 cycles of freezing and thawing, much of t ...195413152279
effectiveness of polyvalent influenza a vaccine during an influenza a-prime epidemic. 195413158335
experimental respiratory infection in monkeys produced by influenza a virus and staphylococcus aureus. 195413171853
experiments on the use of chemicals for the disinfection of air against influenza a virus. 195413231192
on the reproduction of influenza virus; quantitative studies with procedures which enumerate infective and hemagglutinating virus particles.procedures which make possible the enumeration of both infective and hemagglutinating influenza a virus particles have been developed and used in a quantitative investigation on the reproduction of the agent. infective particles were found to be highly unstable and their half-life was only 147 minutes in allantoic fluid at 35 degrees c. both in vitro and in vivo. the instability of infective particles provides an explanation for the rapid accumulation of non-infective particles which retained th ...195413286420
the experimental production of combination forms of virus. iii. the formation of doubly antigenic particles from influenza a and b virus and a study of the ability of individual particles of x virus to yield two separate strains.the simultaneous inoculation of influenza a and b strains into eggs was found to result in the formation of virus which had antigenic properties of both parent strains. the hemagglutinin of the new virus could be inhibited by both a and b antisera and the agent was also neutralized by both sera. this x particle displayed the characteristics of what we have previously called x(1). it did not reproduce itself on multiplying in the egg, but instead yielded parent types. limiting infectious dilution ...195413152278
the stability of human complement-fixing antibodies against lymphogranuloma venereum, psittacosis, influenza a, and influenza b antigens under various conditions of storage. 195413163563
lipid content of standard and incomplete influenza a virus. 195413165714
a comparative study of the equine abortion and equine influenza viruses. 195413173155
serological studies during the 1953 epidemic of influenza a in new york state. 195413174801
experimental production of combination forms of virus. iv. mixed influenza a-newcastle disease virus infections. 195413177596
[effect of influenza virus a shkliaver on the mechanism of transmission of the neural impulse in the superior sympathetic ganglion]. 195413196630
cultivation of equine abortion and equine influenza viruses on the chorioallantoic membrane of chicken embryos. 195413200094
influenza virus-erythrocyte interaction. ii. effect of egg passage on the reaction between a recently recovered influenza a virus and sheep erythrocytes. 195413201760
[modification of antigenic structure of influenza virus a and a1 during five years]. 195413227509
cultivation of the equine influenza virus in suckling syrian hamsters. its similarity to the equine abortion virus. 195413127395
[the viruses of the 1952-3 influenza epidemic].the results of antigenic studies of the viruses received at the world influenza centre from the 1952-3 influenza epidemic are described. as in 1950-1, two main antigenic groups of influenza a viruses could be distinguished. one group, called liverpool, contained strains closely related to 1950-1 liverpool strains. the other, called scandinavian, contained strains related to but not identical with 1950-1 scandinavian viruses. altogether, 175 scandinavian, 33 liverpool, and 4 influenza b virus str ...195414364180
serological behaviour of influenza viruses. i. the effect of different fowl erythrocytes on the results of serological tests.two strains of influenza a virus have been identified which show significant variations in their haemagglutination-inhibition titres when tested with different types of fowl cell.the fowl cells studied in relation to these two strains of virus fall into two distinct groups, arbitrarily labelled type i (low titre) and type ii (high titre).the type i and type ii cells seem related to, but not identical with, the inhibitor-insensitive and inhibitor-sensitive cells described by previous workers.when ...195414364181
[improved method of preparation of influenza viruses a and b for vaccines]. 195413170709
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