| use of an enzyme immunoassay with protein a for rabies antigen and antibody determination. | the rabies antigen quantitation reported here is based on the principle of an enzyme immuno micro assay (eia) using antigen coated polystyrene microtiter plates. in a first step antibodies of known specificity are partially blocked by the antigen to be titrated; in a second step the free remaining antibodies are determined by eia. antirabies vaccines, purified virus or rabies glycoprotein were assayed by that micro-method in comparison with the double neutralization test in tissue culture. moreo ... | 1980 | 6988255 |
| in vivo detection of specific cell-mediated immunity in street rabies virus infection in mice. | in street rabies-infected mice, in vivo expression of delayed type hypersensitivity (dth) measured by the footpad test was revealed by challenge with inactivated fixed rabies virus (rv). the use of bcg as an adjuvant cell-mediated immunity (cmi) was necessary for the production of significant dth levels. typical dth kinetics were obtained, with a maximum at 24 h after the challenge. dth was also found to be at highest levels 4 days after infection with street rabies virus. dth could also be reve ... | 1980 | 6988546 |
| cellular immunity in rabies virus infection: leukocyte-migration inhibition in-vitro. | | 1980 | 6991406 |
| diagnosis of rabies by immunofluorescence in trypsin-treated histologic sections. | after trypsin digestion of 4% formaldehyde (10% formalin)-fixed, paraffin-embedded brain sections, immunofluorescence identification of rabies antigen was successful in three human rabies cases and in experimentally infected mice. the method allows better interpretation of the anatomic localization of rabies antigen and will be helpful in studies of the pathogenesis of rabies. it will also be diagnostically useful where fresh or fresh-frozen brain tissue is not available, although it should not ... | 1980 | 6991727 |
| [rabies]. | the epidemiology, geographic distribution in europe, pathogenesis and diagnosis of rabies are briefly reviewed. criteria are discussed for evaluating cases in which exposure to rabies is suspected. current vaccination programs in switzerland and indications for additional passive immune prophylaxis are mentioned. special attention is directed to postexposure therapy of previously vaccinated persons. further, the recommended time intervals for rabies revaccination of high-risk individuals are dis ... | 1980 | 6994220 |
| experimental chronic rabies in the cat. | two cats, inoculated with a street rabies virus strain, survived with only some progressive debility and atrophy of musculature in the injected limb for 136 weeks. they had continuously increasing titers of neutralizing antibody in serum and in cerebrospinal fluid, and terminally they had high antibody titers in the brain. virus was isolated from two brain specimens of one cat obtained at necropsy; isolation was successful only by explant culture and inoculation of explanted tissue into mice. vi ... | 1980 | 6995713 |
| a bat rabies isolate with an unusually short incubation period. | | 1980 | 6998723 |
| tissue culture technique for routine isolation of street strain rabies virus. | a tissue culture test for the primary isolation of street strain rabies virus from the brains of suspect animals was evaluated. it was found to be reliable and comparable in sensitivity to the standard mouse inoculation technique. the test, which yields final results in 48 h, was performed in bhk-21 cells on tissue culture chamber slides. the addition of diethylaminoethyl dextran to the cell suspension before seeding the slide promoted the subsequent viral invasiveness of positive test specimens ... | 1980 | 6999024 |
| production of spikeless particles of the rabies virus under conditions of low ph. | | 1981 | 7008336 |
| the antibody-binding-test, a useful method for quantitative determination of inactivated rabies virus antigen. | | 1981 | 7012157 |
| identification of rabies virus antigen in the skin of foxes. | | 1980 | 7013372 |
| enteric inoculation with era rabies virus: evaluation of a candidate wildlife vaccine in laboratory rodents. | a series of experiments on the safety and efficacy of enteric vaccination was carried out in laboratory rodents using the era strain of rabies virus both live and inactivated. in the first and second experiments in white norway rats, several methods of inoculation were compared for the development of rabies neutralizing antibody. in later experiments, the potential for disease transmission through salivary excretion of era strain, or through scavenging, or cannibalism were evaluated. enteric ino ... | 1981 | 7016079 |
| [examination of various conjugates for their convenience in rabies diagnostics by immuno-fluorescence (author's transl)]. | | 1981 | 7016495 |
| an ultrastructural and immunofluorescent study of rabies virus in tissue culture for antiviral drug evaluation. | with the purpose of establishing a model for antiviral drug evaluation the era and v319 rabies fixed virus strains were studied in tissue cultures, for studies of the rabies virus cycle. viral incubation was made using a low viral input multiplicity and allowing substances that may alter, cell or virus morphology. immunofluorescence and electron microscopy studies were carried out for quantitative evaluation of structures involved in rabies virus replication after a 24 hours incubation period. t ... | 1981 | 7023412 |
| inactivation of rabies diagnostic reagents by gamma radiation. | treatment of cvs-11 rabies adsorbing suspensions and street rabies infected mouse brains with gamma radiation resulted in inactivated reagents that are safer to distribute and use. these irradiated reagents were as sensitive and reactive as the nonirradiated control reagents. | 1980 | 7024297 |
| [in vitro seroneutralization of rabies virus in leighton tubes, evaluated by immunofluorescence inhibition]. | | 1981 | 7024687 |
| comparison between a modified counterimmunoelectrophoresis test and the indirect fluorescent-antibody test for detection of antibodies to rabies virus in human sera. | the correlation between the modified counterimmunoelectrophoresis test and the indirect fluorescent-antibody test for detecting rabies virus antibodies in human sera was studied, using as a reference the standard mouse neutralization test. higher sensitivity was observed with the counterimmunoelectrophoresis technique than with the indirect fluorescent-antibody method. the counterimmunoelectrophoresis test provides a practical quantitative alternative to the indirect fluorescent-antibody method. | 1981 | 7026611 |
| [current status of the rabies problem]. | | 1981 | 7027662 |
| entry of rabies virus into the peripheral nerves of mice. | young adult mice were inoculated in the hind limb with rabies virus or sindbis virus. rabies 1820b virus antigen was detected in leg sections by immuno-fluorescence at 1 h post-inoculation at sites comparable in form and distribution to cholinesterase-positive sites, which represent motor end-plates (meps). sites which were rabies virus antigen-positive by immunofluorescence were also cholinesterase- positive on double-stained slides. rabies cvs virus detected by autoradiography was similarly di ... | 1981 | 7031182 |
| rabies virus titer from tissues of naturally infected skunks (mephitis mephitis). | rabies virus was titrated from the hippocampus and salivary glands (mandibular, parotid, and sublingual) of 19 naturally infected skunks. selection of the skunks was based on a positive fluorescent antibody test (fat) on the hippocampus. one fat- and virus isolation-negative skunk served as a control. the fat was positive on 19 mandibular salivary glands, 16 parotid glands, and 17 sublingual glands. rabies virus was subsequently isolated in albino swiss mice from all (ie, 19) hippocampi and mand ... | 1981 | 7034605 |
| presence of specific antigens in neuronal cells infected with fixed and street rabies virus strains. | the presence of rabies specific antigens is investigated after infection with different rabies virus strains in neural cell lines and in the central nervous system of laboratory rodents. in fixed rabies infected cells, the rabies glycoprotein is found to be present 48 h after infection, whereas in hamsters this protein was found 5 days after an intracerebral inoculation. in contrast, rabies glycoprotein was not detectable in any of the street rabies-infected cell system by the fluorescent antibo ... | 1981 | 7036643 |
| enzyme-linked immunosorbent assay: a rapid reproducible test for the measurement of rabies antibody. | an enzyme-linked immunosorbent assay (elisa) was developed for detecting igg antibodies to the pitman moore strain of rabies virus in sera from subjects immunised wih hdcs vaccine. end-point titres of antibody were determined using a pocket calculator preprogrammed to analyse absorbence values of test sera and negative controls. the assay was highly reproducible, and very close agreement was achieved when the results were compared with those of the mouse neutralization test. rabies enzyme-linked ... | 1982 | 7038045 |
| rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine. results of initial clinical studies of preexposure vaccination. | to meet the need for a safe, efficacious, and low-cost rabies vaccination program, the michigan department of public health developed a new rabies vaccine: rhesus diploid rabies vaccine, adsorbed (rdrv). initial clinical studies were conducted in 534 volunteers using preexposure protocols consisting of two injections of rdrv given 1, 2, or 4 weeks apart. this new rabies vaccine induced an excellent rabies virus antibody response two to three weeks after vaccination: antibody levels were superior ... | 1982 | 7038159 |
| pathogenesis of rabies in dogs inoculated with an ethiopian rabies virus strain. immunofluorescence, histologic and ultrastructural studies of the central nervous system. | dogs were inoculated with either an ethiopian of mexican rabies virus strain. the distribution of viral antigen and lesions were studied by immunofluorescence, histologic and electron microscopic techniques. in all dogs inoculated with the ethiopian rabies virus strain, tremendous whorls of filamentous fluorescing aggregates were observed throughout the brain; these were not observed in dogs inoculated with the mexican virus. lesions consisted on neuronal degeneration and neuronophagia, associat ... | 1982 | 7039557 |
| rabies virus tropism in naturally infected skunks (mephitis mephitis). | | 1981 | 7041707 |
| rabies in a litter of skunks predicted and diagnosed by skin biopsy. | four juvenile skunks were vaccinated against rabies, descented, and then placed in 4 different households. an illness subsequently developed in 3 of the skunks that was confirmed as rabies, by examination of biopsy specimens of muzzle skin using immunofluorescence microscopy. in 1 clinically normal skunk, the skin was found to be test-positive, predicting that rabies would develop; the signs of rabies became evident in 48 hours. the infection was considered to be field acquired rather than vacci ... | 1981 | 7042667 |
| atypical rabies virus in cats and a dog in zimbabwe. | | 1982 | 7043888 |
| cellular tests for assessing the immunogenicity of rabies vaccines. | | 1981 | 7053012 |
| is the acetylcholine receptor a rabies virus receptor? | rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. these findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. the binding of virus to acetylcholine receptors, which are present in high densit ... | 1982 | 7053569 |
| dual role of the immune response in street rabiesvirus infection of mice. | the cellular and humoral immune responses of mice to footpad injection of salivary gland suspensions of street rabiesvirus were investigated. suppression of these responses with cyclophosphamide both increased the overall mortality rate from (50 to 100%) and delayed onset of disease signs and death for 1 to 2 weeks. despite the absence of disease signs in these immunosuppressed animals, virus was present in the central nervous system, as shown by fluorescent-antibody staining of corneal epitheli ... | 1982 | 7054123 |
| human diploid cell rabies vaccine. effectiveness of immunization with small intradermal or subcutaneous doses. | to determine antibody responses to small doses of human diploid cell rabies vaccine (hdcv), we determined rabies antibody titers in 124 volunteers who had been vaccinated with one of five primary preexposure regimens. in a sixth group of 47 persons previously vaccinated with duck embryo rabies vaccine (dev), we evaluated the booster responses after a 0.1-ml dose of intradermal (id) hdcv. persons in all five groups undergoing primary immunization received three doses of vaccine, one each on days ... | 1982 | 7057603 |
| rabies in ethiopia. | rabies is one of the most severe infectious diseases in ethiopia, with many cases of the disease diagnosed in various parts of the country. the dog is the species most responsible for human exposure, with over 98% of the human cases and vaccinations due to the bite of rabid or suspected rabid dogs. most of the treatments are due to stray dogs that bite, escape and are not available for observation. most of the people who die of rabies are under 40 years of age, and among adults, the majority of ... | 1982 | 7058785 |
| hemolysis and cell fusion by rhabdoviruses. | | 1982 | 7060734 |
| rabies treatment with vaccine of the fuenzalida-palacios type. | | 1982 | 7074254 |
| excretion of rabies virus in the saliva of dogs. | thirty-nine dogs were injected intramuscularly with either an ethiopian strain or a mexican strain of rabies virus. the excretion of rabies virus in the saliva was studied before and during illness. nine of 17 dogs that died after injection with the ethiopian strain had virus in the submaxillary glands. four of these dogs excreted virus in the saliva up to 13 days before signs of disease were observed. sixteen of 22 dogs that died after injection with the mexican strain had virus in the submaxil ... | 1982 | 7077094 |
| antibody responses to human diploid cell vaccine for rabies with and without human rabies immune globulin. | one hundred one volunteers with no exposure to rabies were given human diploid cell vaccine (hdcv) for rabies with or without 20 international units of human rabies immune globulin (hrig)/kg of body weight to evaluate schedules for therapy with hdcv and hrig after exposure. all of the volunteers who received three or more doses of hdcv alone or four or more doses of hdcv with hrig developed high titers of neutralizing antibodies by day 35, which persisted for at least 60 days. by day 7, of the 6 ... | 1982 | 7077095 |
| [specific activity of an uv-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule]. | the results obtained in the study of the specific potency of rabies vaccine prepared from sheep brain tissue and inactivated by uv irradiation indicate that, even in the presence of the lowest immunogenicity index (0.5), 5-6 injections of the vaccine, made not daily, but at interval of 3 and 7 days, induced the production of antibodies in the titers not lower than those resulting from 14-20 daily injections of the same vaccine or fermi vaccine. the preparation inactivated by uv irradiation shoul ... | 1982 | 7080770 |
| specific activity of concentrated and purified cell culture rabies vaccine (cpcrv) from the strain vnukovo -32-107 in an experiment with therapeutical immunization of humans. | reactogenicity and specific activity of three series of concentrated and purified cell culture rabies vaccine (cpcrv) were studied in an experiment of therapeutical immunization of 300 human subjects bitten by domestic animals, category "c". cpcrv was well tolerated; when administered intramuscularly, it did not provoke local reactions, while general reactions, such as temporary headaches and indisposition, were observed in 4% of cases. intradermal revaccination with cpcrv was followed by local ... | 1982 | 7086124 |
| vaccine-induced rabies in four cats. | vaccine-induced rabies in 4 cats was characterized by rigid posterior paralysis. in 3 cats, paralysis began in 1 hindlimb and rapidly spread to the other hindlimb. later, forelimb and cranial nerve deficits were noticed. onset of clinical signs was 13 to 17 days after im vaccination with an era-strain modified live-virus rabies vaccine approved for use in cats. each cat eventually was euthanatized. in each case, brain tissue was found to contain rabies virus on fluorescent antibody and mouse ino ... | 1982 | 7096177 |
| evaluation of a human diploid cell strain rabies vaccine: final report of a three year study of pre-exposure immunization. | the antibody responses of 194 volunteers were studied for up to 3 years after primary immunization with one, two or three doses of human diploid cell rabies vaccine, administered either in 0.1 ml volumes intradermally (i.d.) or as 1.0 ml intramuscularly (i.m.). sero-conversion occurred in 95% of subjects after the first injection and in 100% after the second. the highest titres and most durable antibody responses were induced by three injections of vaccine. booster doses were administered either ... | 1982 | 7096998 |
| isolation and study of temperature-sensitive mutants of rabies virus. | one-hundred and seventeen temperature-sensitive (ts) mutants have been isolated from the challenge virus strain (cvs) of rabies virus (rv). the criterion used for this selection was the absence of plaque-forming units on cer cells under agarose medium at the non-permissive temperature (npt) of 38.5 degrees c. of these mutants, 102 were induced by 5-fluorouracil. this compound was much more effective as a mutagen than either nitrous acid or the alkylating agents ethyl methanesulphonate and methyl ... | 1982 | 7097248 |
| reproducible plaquing system for rabies virus in cer cells. | | 1982 | 7107802 |
| intradermal immunization with human diploid cell rabies vaccine. serological and clinical responses of persons with and without prior vaccination with duck embryo vaccine. | intradermal administration of human diploid cell rabies vaccine (hdcv) was investigated in an attempt to reduce the current high cost of preexposure rabies prophylaxis. the study population consisted of 240 volunteers from a veterinary hospital, 165 of whom had prior vaccination with duck embryo rabies vaccine (dev). vaccine safety was good; only minor reactions were experienced, all of which resolved spontaneously. serological responses to intradermal hdcv were excellent; 209 (99.5%) of the 210 ... | 1982 | 7109184 |
| animal rabies. papers presented at the joint scientific meeting on animal rabies. 3 to 5 june 1982, nancy, france. | | 1982 | 7128057 |
| scanning and freeze-fracture electron microscopy of rabies virus infection in murine neuroblastoma cells. | a persistent infection of cvs strain of rabies virus was established in murine neuroblastoma cells, c-1300, by a serial passage of the cells infected with a low input multiplicity. little cytopathic effects were seen in the infected cultures and the cell growth was not interfered, although 90-100% of the cells were bearing intracytoplasmic inclusions and the infectious virus was constantly recovered from the supernatant. scanning electron microscopy disclosed preferential budding of the virus fr ... | 1982 | 7128058 |
| avirulent mutants of the cvs strain of rabies virus. | two avirulent mutants of the cvs strain of rabies virus have been isolated on the basis of their loss of sensitivity to antiglycoprotein neutralizing monoclonal antibodies. with the exception of virulence, both retain general characteristics of the cvs strain of the rabies virus. after inoculation, they induce a strong and rapid immune response in adult mice. in this respect, however, they are quite different from the parental cvs strain. surviving mice are protected against intramuscular challe ... | 1982 | 7128059 |
| [role of interferon in rabies immunity]. | cell cultured rabies vaccines, usually induce a good production of interferon. a comparative study shows that vaccines from primary explantation cell cultures are better interferon inducers. taking into account the importance of this induction in rabies vaccination, a study showing the role of leucocyte interferon (alpha-type) is achieved. results show that leucocyte interferon (originating from the red cross, osaka, japan and institut pasteur production, paris) inhibits the formation of fluores ... | 1982 | 7128060 |
| [haemagglutination inhibition test: improvements, limits and advantages of the method. comparison with neutralization test]. | in this study, we report some technical improvements which enable us to envisage wider use of the haemagglutination test and haemagglutination inhibition of the rabies virus. moderated trypsination of sensitive red blood cells and their counting are important parameters. an interesting application of the test was the haemagglutination competition enabling the amount of soluble glycoprotein (obtained during the fractionating of the virus components) to be evaluated. from antibody kinetics of vacc ... | 1982 | 7128064 |
| small mammal studies in a sad baiting area. | studies in the laboratory or in the field on the effect of sad virus on small rodents are reported. laboratory experiments by oral inoculation of sad strain in a wide variety of small mammals led to the conclusion that spontaneous sad transmission from rodent to rodent is a rare event. field experiments were conducted by live-trapping, sacrifice and analysis of 192 apodemus sylvaticus, 28 clethrionomys glareolus and 48 crocidura russula. they gave no indication that sad virus became established ... | 1982 | 7128065 |
| safety tests with flury hep strain 675 in wild-living european mammals. | for the evaluation of residual pathogenicity of flury hep strain 675, the vaccinal virus was orally administered to 207 animals belonging to 15 wild-living and 1 domestic species. rabies virus antigen could be demonstrated by fa method in 20 animals. reisolation of the virus was possible from 23 animals within the first two weeks after application, the titres being very low. during the observation period of 100 days no symptoms of rabies could be observed in the animals tested. | 1982 | 7128066 |
| effectivity of oral vaccination of foxes against rabies with flury hep strain 675. | a group of 14 adult foxes was orally vaccinated with 2 ml flury hep strain 675, titre 10(8.2 tcid50. each fox seroconverted neutralizing antibody titres ranging between 1:40 and 1:640. these foxes survived an intramuscular challenge with 8000 mouse ld50 pathogenic rabies virus, whereas six out of seven unprotected control foxes died within 28 days. this study was accompanied by virus isolation, fluorescence microscopic examination and neutralization tests. | 1982 | 7128067 |
| [evaluation of an experimental rabies vaccine by the oral and intestinal route with inactivated vaccines, concentrated or non-concentrated]. | application of beta-propiolactone inactivated rabies vaccine prepared in bovine embryo kidney cells, concentrated or non concentrated, by intestinal or oral route resulted in antibody production in rats and cats. 80-100% of vaccinated rats were protected against challenge with street rabies virus. the same vaccines (lyophilized in gelatin capsules) stimulated antibody production in more than 50% (5/8) cats which received the vaccine by the oral route. | 1982 | 7128069 |
| [attenuated rabies virus, era strain, in cattle and dogs vaccinated with multiple doses]. | investigation on the vaccination of 18 cattle and 5 dogs against rabies is reported. each animal received multiple doses of era strain vaccine intramuscularly in the gluteal or masseter region. the saliva, the brain and salivary glands of the vaccinated animals were examined to detect the presence of era virus using immunofluorescent test and mouse inoculation. the virus was never found in the saliva and organs of treated animals. circulating antibodies against era rabies virus were detected in ... | 1982 | 7128070 |
| antibody levels following era rabies vaccine in cattle. | the humoral response in cattle treated with era strain rabies vaccine, was studied utilizing the following criteria: antibody titres determined by rffit, seroimmunological monitoring of experimentally vaccinated animals, a comparison of data obtained from cattle vaccinated and maintained under field conditions in the absence of anamnestic information. the average antibody responses in the field experiment are in agreement with the laboratory animal response, both showing highest levels at day 15 ... | 1982 | 7128071 |
| the structural proteins of rabies virus. | the five structural proteins of rabies virus, l, g, n, m1 and m2 have been re-evaluated in light of recent results. it has been found that the m1 protein is associated with the n protein which together with the l protein and the rna forms the nucleocapsid complex. only the g and m2 proteins could be visualized on the surface of infected cells. therefore, it is proposed that the m1 protein be renamed ns analogous to vesicular stomatitis virus and that the m2 protein, being the only membrane prote ... | 1982 | 7128073 |
| purification, concentration and evaluation of rabies virus antigen. | a number of concentration and purification procedures for rabies virus antigen have been developed during the last decades but only ultrafiltration and density gradient centrifugation have been found suitable for large scale production. the antibody binding test developed by arko, wiktor and sikes was modified and was found useful for evaluation of inactivated antigen-concentrates. this test was used as an 'in process' control. three examples of practical experience are reported and discussed. | 1982 | 7128074 |
| [modalities of production and immunity conferred by an inactivated rabies vaccine originating from cell culture]. | further to guidelines advised by the world health organization, an inactivated rabies vaccine was prepared from virus propagated on cell culture. this vaccine is presented either in the freeze-dried form or in the liquid form together with an immunity adjuvant. the specific and nonspecific immunity of the vaccine is excellent. the potency, tested in laboratory animals and in species for which the vaccine is intended, satisfies recommendations published by the w.h.o. the immunity persistence, eva ... | 1982 | 7128075 |
| potency of two rabies vaccines in cats as determined by antibody assay and virulent virus challenge. | the persistence of immunity induced by a modified live virus rabies vaccine (sad strain) and an inactivated rabies vaccine combined with panleukopenia vaccine in cats was studied serologically and by virulent rabies virus challenge. the source of challenge virus was a suspension of a dog salivary gland. all 16 cats vaccinated with the inactivated vaccine developed high antibody titres and 15 were protected against the virus challenge. all 8 cats vaccinated with the mlv vaccine produced a serolog ... | 1982 | 7128076 |
| [radio-tracking of rabid foxes]. | three wild foxes were trapped, inoculated with rabid fox salivary glands virus and radio-tracked straightaway for about three weeks until the death of the animal. comparison of movements between incubation and clinical period indicate principally no obvious alteration of the activity area; an important increase in movement, especially during the day-time and lastly some variable changes in the activity pattern according to the individual. a common characteristic was a long period of immobility, ... | 1982 | 7128084 |
| [influence of rabies virus culture duration on viral glycoprotein integrity]. | regardless of the duration of the culture period, the amount of both glycoprotein g and sialic acid bound to the rabies virion as not modified. the major proteins of the viral suspension were the same proteins as those of the virion, except one glycoprotein (mw 70,000). | 1982 | 7128091 |
| [possible role of ticks as a reservoir of rabies virus]. | in western europe the fox and other carnivora are parasitized by two specific ticks. the study of host-parasite relationships and knowledge of rabies epidemiology led us to investigate for a possible part played by ticks as reservoir of rabies virus. several hundreds of ticks (pholeoixodes hexagonus and pholeoixodes canisuga) were collected on wild foxes. ticks collected from naturally infected rabid foxes were set on healthy foxes in order to contaminate them. ticks collected from non-rabid fox ... | 1982 | 7128092 |
| [molecular and cellular aspects of the pathogenesis of rabies]. | the true causes of the beginning of the symptoms and the eventual mortality of rabies are not very well known. immunopathological factors certainly intervene, but they only complete a process of neuronal alteration. contrary to other viruses which lyse the infected cells, the rabies virus does not necessarily destroy the neurones which are the preferential target cells. on the contrary, rna synthesis is stimulated during cns infection by the rabies virus. synthesis is not stimulated by the multi ... | 1982 | 7128098 |
| [progression of the rabies virus in the visual system of the rat]. | the cvs rabies virus, inoculated in the anterior chamber of the eye, is transported from the retina to the central nervous system only along the accessory optic tract and invades transsynaptically its terminal nuclei. on the other hand the retino-geniculo-cortical system is affected much later. thus the virus shows a special affinity for a well defined neuronal system and behaves as a precise tracer of its intracerebral connections. | 1982 | 7128099 |
| rabies virus pathogenicity and challenge. influence of the method of preparation, the route of inoculation, and the species. comparison of the characteristics of the modified, fixed and wild strains. | the challenge we carried out, which regularly brought about the death of the control animals, led us to study the different factors influencing the pathogenicity of the rabies virus. so, the method of preparation is important. the strain nyc, prepared from the salivary glands is extremely pathogenic for dogs; however, when it is prepared from mouse brains after nine passages have been made, it proves to be already partially modified. one then notices a death-rate which is less severe, even when ... | 1982 | 7128100 |
| fatal encephalitis apparently due to rabies. occurrence after treatment with human diploid cell vaccine but not rabies immune globulin. | | 1982 | 7131683 |
| a sensitive bioassay system for detecting defective interfering particles of rabies virus. | | 1982 | 7135836 |
| [experimental transmission of rabies to the ferret by an ixodoidea: pholeoixodes rugicollis (schultze and schlottke, 1929)]. | | 1982 | 7136476 |
| haemadsorption test for rabies virus. | | 1982 | 7142683 |
| [humoral immune response as a laboratory criterion for evaluation of the effectiveness of rabies vaccines]. | | 1982 | 7144329 |
| [effect of cyclophosphane on the experimental production of abortive and chronic forms of rabies]. | | 1982 | 7147907 |
| a clinical study of merieux human rabies immune globulin. | | 1982 | 7153223 |
| geographic and seasonal distribution of rabies in skunks, foxes and bats in texas. | the geographic and seasonal distributions of the pathobiocenoses formed by rabies virus, the biotic provinces of texas, and skunks, foxes and bats were described using synoptic mapping and enumeration by calendar month. autocorrelation functions with 95% confidence intervals were calculated for the skunk pathobiocenose for lag periods up to 36 mo in length. the geographic distributions were fundamentally different, but all overlapped. the skunk and fox pathobiocenoses were associated with provin ... | 1982 | 7154216 |
| [biological variants of a population of strains of the rabies street virus]. | experiments in mice weighing 6-7 g showed that a population of wild street rabies virus strains could contain from 1 to 3 biologic variants determining the clinical characteristics, duration of the incubation period and of the disease, and virus titres in the brain. fox strains l-1 and l-2 produced only paralytic rabies, the be strain isolated from a badger induced paralytic and chronic disease, and the population of the yak strain isolated from a boy bitten by a fox and timely given a complete ... | 1982 | 7157781 |
| intradermal use of human diploid cell vaccine for preexposure rabies immunizations. | in a study involving 240 faculty, students, and staff at the university of georgia college of veterinary medicine, 0.1 ml of a rabies human diploid cell vaccine administered intradermally on days 0, 7, and 28 induced adequate rabies antibody (greater than or equal to 0.5 iu/ml of serum) in all subjects by day 49. there were no significant differences in mean titers between groups of individuals with different rabies immunization histories by using a newly proposed index system for reporting such ... | 1982 | 7161170 |
| immunization of foxes vulpes vulpes by the oral and intramuscular routes with inactivated rabies vaccines. | inactivated rabies vaccines prepared from common vaccine strains of virus were inoculated into foxes by the intramuscular and intestinal route. there were differences among the vaccines in the duration of antibody produced after intramuscular administration. inactivated vaccines deposited directly into the lumen of the duodenum by means of a fiberscope caused seroconversion in some foxes, especially following a booster dose, but the antibodies produced were for the most part of short duration. t ... | 1982 | 7172102 |
| [oral immunization of foxes against rabies: stabilization and use of bait for virus application]. | | 1982 | 7180249 |
| [antigenic variants of the rabies virus. selection with antiglycoprotein monoclonal antibodies]. | | 1982 | 7181560 |
| [preventive antirabies vaccination. evaluation of humoral immunity]. | | 1982 | 7181561 |
| [comparative study of 2 postexposure antirabies vaccines]. | | 1982 | 7181562 |
| [the reservoir of rabies virus in tunisia]. | | 1982 | 7181568 |
| [antigenic spectrum of wild strains and vaccinal strains of rabies virus in senegal defined by antinucleocapsid monoclonal antibodies]. | | 1982 | 7181573 |
| studies of the presence of rabies virus among stray dogs in dhaka city. | one hundred and thirty one stray dogs were captured from dhaka city. anti-mortem as well post-mortem examination of the dogs for rabies were conducted. microscopic studies and biological tests were carried-out with dog's brain for the detection of rabies virus. one dog was found to have rabies virus in its brain. the stray dogs under dhaka municipal corporation area therefore, seem to harbour rabies virus in their brains and could be a source of potential danger to the community after the full d ... | 1982 | 7184499 |
| [determination of the protective value of anti-rabies vaccines for human use in international units in the nih-test]. | | 1982 | 7185030 |
| non-bite transmission of rabies in kudu (tragelaphus strepsiceros). | the titres of rabies virus in the saliva of kudu are higher than those of the salivary glands. the high titres are an indication of active excretion and multiplication in tissues other than the salivary glands. two out of 4 kudu died of rabies after experimental infection by the instillation of infected saliva onto their buccal and nasal mucosae. mice and 2 cattle resisted a similar exposure. kudu also developed antibodies against rabies after instillation of hep flury virus onto their nasal and ... | 1982 | 7185035 |
| [development and persistence of the humoral immune response induced by the preventive treatment with rabies vaccine (hdcs) in a group of laboratory workers]. | | 1982 | 7187849 |
| [immune rabies status of 200 vaccinated dogs from the canton of zurich]. | | 1982 | 7201161 |
| rabies virus infection of a flying fox bat, pteropus policephalus in chandigarh, northern india. | the present communication reports for the first time in south east asia an active infection of frugivorous flying fox bat (pteropus poliocephalus) with a virus belonging to the rhabdo virus group -- a bat virus. negri body like structures were demonstrated by seller's stain and direct immunofluorescence in the brain and salivary gland of the dead bat. the virus was isolated after intracerebral inoculation of homogenate of the bat brain, salivary gland or brown fat separately in new born mice. | 1980 | 7210163 |
| [activity control of inactivated rabies vaccines. critical study of the n.i.h. test using the so-called 'peripheric test' as an experimental model]. | | 1981 | 7217107 |
| comparative study of rabies virus persistence in human and hamster cell lines. | persistent infections by rabies virus in bhk-21/13s and hep-2 cells were studied comparatively. no evidence of interferon production, selection of virus-resistant cells, or integration of the viral genome could be found. persisting viruses replicated efficiently at 34, 36, and 40 degrees c. both persistently infected cultures released defective interfering virus particles. a cyclical pattern of infection, which was not characteristic of the persistently infected hep-2 system, was observed in per ... | 1981 | 7218421 |
| antibody-mediated enhancement of rabies virus. | | 1981 | 7219541 |
| recovery from clinical rabies of 2 dogs inoculated with a rabies virus strain from ethiopia. | two dogs, inoculated with a strain of rabies virus from ethiopia, showed typical signs of rabies 8 days after inoculation. after 3 or 4 days with a deterioration in the physical condition, both animals began to recover, as shown by increased muscular movements, reaction to stimuli, awareness of surroundings, and attempts to rise. both animals recovered completely, although 1 then died of pseudomonas bacterial pneumonia. an increase in serum-neutralizing antibody and in csf or brain-neutralizing ... | 1980 | 7224288 |
| determination of serum neutralization antibodies to rabies virus by a modified counterimmunoelectrophoresis test. | a modified counterimmunoelectrophoresis (cie/sn) technique was developed as a diagnostic procedure for the detection of serum-neutralizing antibodies to rabies virus. cie/sn test results with sera from individuals undergoing postexposure rabies immunization compared favorably with those obtained by the standard mouse neutralization test procedure. fractionation of selected sera by sephadex g-200 column chromatography demonstrated that serological activity involved in both procedures was present ... | 1980 | 7229005 |
| cellular and humoral immune response in human beings vaccinated with rabies vaccine. | | 1980 | 7229310 |
| complement fixing antigen in rabies. v. effect of bacteriostatic agents on its stability. | | 1980 | 7229311 |
| [isolation of rabies virus from common hamster (cricetus cricetus) in czechoslovakia]. | | 1980 | 7246383 |
| [peroral infection with rabies virus in fox and domestic cat]. | | 1980 | 7246384 |
| [pathomorphology of abortive rabies]. | white random-bred mice inoculated intraperitoneally with street rabies virus were found to have numerous babes-negri bodies in cerebral neurons very frequently up to 5 days of the disease. on the 7-11th days of the disease the inclusions were found in some neurons in 11 of 17 mice examined. among 24 mice with abortive rabies (recovering completely or surviving with residual symptoms such as pareses or paralysis) examined on the 20-240th days after the onset occasional babes-negri bodies were fou ... | 1981 | 7257316 |
| [rna synthesis in cells chronically infected with rabies virus]. | rnas of predominantly subgenome size were synthesized in bhk-21 and hep-2 cells chronically infected with rabies virus in the presence of actinomycin d. an analysis of glyoxale-denaturated intracellular viral rnas in agarose gel showed the subgenome size of rna not to be due to its conformation alterations. hybridization of intracellular rnas with 125i-rna or k3h-kdna of rabies virus demonstrated marked reduction in both transcription and replication of viral genome in chronic infection as compa ... | 1981 | 7257325 |
| generation of hybridoma cell lines producing monoclonal antibodies against toxoplasma gondii or rabies virus following fusion of in vitro-immunized spleen cells with myeloma cells. | | 1981 | 7259110 |
| experimental rabies in cats: immune response and persistence of immunity. | experimental rabies was studied in cats under defined conditions. a correlation between the virus dosage and the incubation period was established and results were compared with those published previously by others. the susceptibility of cats to rabies virus appears to be paradoxical. the persistence of the immunity induced by an inactivated rabies vaccine prepared form cell culture-propagated virus used in combination with feline panleukopenia vaccine, with or without adjuvant, was studied thro ... | 1981 | 7261592 |