| buoyant density of canine distemper virus. | | 1973 | 4730482 |
| [assessment of the efficacy of a heterologous (measles) vaccine against distemper]. | | 1973 | 4788160 |
| experimental canine distemper virus-induced lymphoid depletion. | thirty-four gnotobiotic dogs were used to study the effects of r252 canine distemper virus (cdv) infection on the lymphoid system. twenty-one dogs were inoculated parenterally, and 6 dogs were infected by contact exposure to inoculated littermates. seven littermate dogs were maintained as uninfected controls. the means of the absolute lymphocyte counts of dogs infected with r252 cdv were significantly decreased for 7 weeks after infection. the lymphocyte counts failed to return to normal in 7 do ... | 1974 | 4809312 |
| letter: a possible animal model for severe demyelinating diseases of man. | | 1974 | 4816995 |
| relationship between measles and canine distemper viruses determined by delayed type hypersensitivity reactions in dogs. | | 1974 | 4819642 |
| proceedings: preliminary evaluation of pathogenic and immunogenic properties of the flury lep and hep strains of rabies virus multiplied in chick embryo fibroblasts. | | 1974 | 4828510 |
| letter: measles-associated optic neuritis in man and canine distemper. | | 1974 | 4855660 |
| [on the application of immunohistology in veterinary pathology]. | | 1966 | 4862633 |
| the effects of canine distemper virus on explant tissue cultures of canine cerebellum. | | 1968 | 4880795 |
| relationships among measles, canine distemper and rinderpest viruses. | | 1968 | 4886887 |
| pathogenesis of canine distemper. | | 1969 | 4894003 |
| distemper pathogenesis in dogs. | | 1970 | 4912306 |
| comments on pathogenesis of canine distemper. | | 1970 | 4912307 |
| measles vaccine for protection of dogs against canine distemper. | | 1970 | 4912308 |
| federal laboratory testing requirements for canine vaccines. | | 1970 | 4922196 |
| the fluorescent antibody test as a diagnostic test for canine distemper in naturally infected dogs. | | 1971 | 4930869 |
| etiologic studies of old dog encephalitis. i. demonstration of canine distemper viral antigen in the brain in two cases. | | 1971 | 4945659 |
| clinical and immune response of alien hosts to inoculation with measles, rinderpest, and canine distemper viruses. | | 1965 | 4956660 |
| isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. | | 1969 | 4980073 |
| application of the electroprecipitin test to the detection of the virus of canine distemper. | | 1970 | 4983793 |
| a note on the use of plaque reduction to test serums for canine distemper antibodies. | | 1970 | 4991501 |
| a comparative electron microscopic study on the morphogenesis of canine distemper and rinderpest viruses. | | 1971 | 4994230 |
| slow virus diseases of the central nervous system. | | 1971 | 4999325 |
| subacute sclerosing panencephalitis, measles, rabies and progressive multifocal leukoencephalopathy. | | 1971 | 5000224 |
| simultaneous use of contrasting fluorochromes to separate measles and canine distemper viruses in a common system. | measles and canine distemper viruses were grown together in a vero monkey kidney cell line. each virus could be identified and individually titrated by using the color contrast produced by the reddish tetra-methyl rhodamine isothiocyanate-tagged antimeasles conjugate and the green fluorescein isothiocyanate-tagged antidistemper conjugate. both blue light and green light were used for the excitation of the fluorochromes. incident light was transmitted to the specimen by a vertical illuminator of ... | 1971 | 5000868 |
| observations on viral demyelinating encephalomyelitis. canine distemper. | | 1972 | 5021319 |
| immune response of pups to modified live-virus canine distemper-measles vaccine. | | 1972 | 5039517 |
| the growth and cytopathogenicity of virulent and attenuated strains of canine distemper virus in dog and ferret macrophages. | | 1971 | 5090886 |
| serum sialic acid values in dogs with canine distemper. | | 1971 | 5103651 |
| light and electron microscopic studies of lymph node of mink exposed to canine distemper virus. | | 1971 | 5104929 |
| [comparative morphology of measles, distemper and rinderpest viruses]. | | 1971 | 5169406 |
| distemper vaccine trials in two genotypes of mink in denmark. | | 1971 | 5169533 |
| the antibody response and the protection obtained by using different types of vaccines in two genotypes of mink. | | 1971 | 5169534 |
| the influence of diethyl ether inhalation on experimental canine distemper. | | 1968 | 5184660 |
| international standard for anti-canine-distemper serum. | the central veterinary laboratory, weybridge, england, was requested by the who expert committee on biological standardization to obtain suitable material for an international standard for anti-canine-distemper serum and to arrange a collaborative assay. seven laboratories in 6 countries assayed a batch of anti-canine-distemper serum against 3 test preparations. on the basis of the results obtained, the material has been established as the international standard for anti-canine-distemper serum a ... | 1968 | 5306102 |
| fluorescent antibody technique as a diagnostic test for canine distemper infection: detection of viral antigen in epithelial tissues of experimentally infected dogs. | | 1967 | 5340996 |
| [on the nosologic value of the topography and structuring of nervous lesions in comparative pathology. (apropos of viroses in dogs and their relationship to certain human diseases considered to be viroses)]. | | 1969 | 5408267 |
| the immunologic concept of heterotypic resistance. | | 1970 | 5422524 |
| the response to measles and distemper virus in immuno-suppressed and normal dogs. | | 1970 | 5422526 |
| increased growth of viruses in lymphocytes treated with heterologous antilymphocyte serum. | | 1970 | 5425460 |
| ultrastructure of canine distemper virus in explant tissue cultures of canine cerebellum. | | 1970 | 5464974 |
| effect of adrenalectomy on the lymphoid lesions in dogs with experimentally induced canine distemper. | | 1970 | 5469544 |
| the susceptibility of a dog kidney cell-line (mdck) to canine distemper, infectious canine hepatitis and canine herpes virus. | | 1970 | 5498574 |
| development of a cell culture system susceptible to measle, canine distemper, and rinderpest viruses. | | 1967 | 5600774 |
| [comparative observations on distemper and measles viruses by electron microscopy]. | | 1967 | 5627703 |
| [isolation of a strain of virus from carré's disease with unusual biological properties]. | | 1967 | 5630212 |
| the virus of canine distemper in cell culture. i. adaptation of canine distemper virus to growth and serial passage in ferret kidney cell cultures and in bs-c-1 cell cultures. | | 1968 | 5648804 |
| the virus of canine distemper in cell culture. ii. effect of serial passage in ferret kidney cell cultures and bs-c-1 cell cultures on the virulence of canine distemper virus. | | 1968 | 5648805 |
| recovery of canine distemper virus from subcultured primary dog kidney cell culture. | | 1968 | 5651194 |
| experiences with measles virus in canine distemper prophylaxis. | | 1968 | 5654341 |
| studies with an attenuated canine distemper vaccine derived from chick embryo cultures. | | 1968 | 5693317 |
| potency of an attenuated canine distemper vaccine derived from chick embryo cell cultures. | | 1968 | 5693318 |
| stability of attenuated canine distemper vaccine derived from chick embryo tissue culture. | | 1968 | 5698872 |
| [division of cells infected with canine distemper virus]. | | 1968 | 5749494 |
| canine distemper in the family mustelidae. | | 1969 | 5816648 |
| thermostability of distemper virus and its neutralization by antibody. | | 1965 | 5858322 |
| comparison between the immunizing effect in dogs and ferrets of living distemper vaccines, attenuated in dog tissue cultures and embryonated eggs. | | 1965 | 5864792 |
| propagation of rinderpest virus in suckling mice and its comparison to murine adapted strains of measles and distemper. | | 1965 | 5882876 |
| [studies on adaptation of avianized distemper virus to suckling mice]. | | 1964 | 5896577 |
| [pathological studies on canine distemper. 1. histopathological changes in ferrets infected with experimental canine distemper]. | | 1965 | 5896588 |
| effect of visible light on canine distemper virus. | nemo, george j. (the catholic university of america, washington, d.c.), and ernest c. cutchins. effect of visible light on canine distemper virus. j. bacteriol. 91:798-802. 1966.-canine distemper virus (cdv) was inactivated by visible light. the virus was light-sensitive in fluid suspension (in vitro) as well as during intracellular replication (in vivo). the addition of calf serum or glutathione reduced the extent of inactivation. cdv was less sensitive when suspended in distilled water or in t ... | 1966 | 5934499 |
| [characteristics of measles and distemper viruses on the cultured kidney cells of dogs]. | | 1966 | 5951558 |
| persistence of antibodies following vaccination against canine distemper and the effect of re-vaccination. | | 1966 | 6006405 |
| introduction to the symposium on canine distemper immunization. | | 1966 | 6008141 |
| the epizootiology of distemper. | | 1966 | 6008142 |
| the significance of passive immunity and the biological tests used in the study of distemper. | | 1966 | 6008143 |
| inactivated canine distemper virus vaccine. | | 1966 | 6008145 |
| heterotypic virus vaccines. | | 1966 | 6008152 |
| changes in the nitrogen balance and serum proteins during an attack of distemper and coccidiosis in the dog. | | 1967 | 6069143 |
| use of alveolar macrophages for cultivation of canine distemper virus. | | 1967 | 6079942 |
| a review of the etiology of multiple sclerosis. | the geographic distribution of multiple sclerosis and the influence of migration on the risk of contracting it point to an environmental factor as cause of the disease. this environmental factor might be a virus which might produce the demyelination process through an autoimmune reaction against components of the central nervous system. the other possible cause of multiple sclerosis is a genetic susceptibility, inferred from the higher risk for the disease found among relatives of patients with ... | 1984 | 6099345 |
| search for canine-distemper-virus antibodies in multiple sclerosis. a detailed virological evaluation. | sera and cerebrospinal fluid samples from multiple-sclerosis (ms) patients, matched controls, and subacute sclerosing panencephalitis (sspe) patients were analysed for the presence of antibodies specific for measles and canine distemper virus (cdv). virus-specific antibodies were identified by haemagglutination inhibition, neutralisation, and immune precipitation in combination with polyacrylamide-gel electrophoresis. sspe and ms patients had a higher antibody activity towards measles virus than ... | 1980 | 6107454 |
| does virus persist in the uvea in multiple sclerosis, as in canine distemper encephalomyelitis? | epidemiological studies suggest that multiple sclerosis (ms) might be triggered by an infectious agent. uveitis has been observed in a small percentage of ms patients. dogs with canine distemper encephalomyelitis, another demyelinating disease of the central nervous system, have an anterior uveitis which is usually mild and asymptomatic, and dogs with persistent cns infection and chronic distemper encephalomyelitis harbour virus persistently in the uvea. these observations in dogs suggest that p ... | 1983 | 6135875 |
| immunological relationships between homologous structural polypeptides of measles and canine distemper virus. | the major structural polypeptides of measles and canine distemper virus (cdv) were isolated by sds-polyacrylamide slab gel electrophoresis. rabbit hyperimmune sera directed against the isolated ha, p, np, f and m polypeptides were prepared. in addition, rabbit hyperimmune sera directed against purified native internal components of measles virus and against purified virions of measles and cdv, untreated or treated with trypsin, were prepared. these sera were used to study the immunological relat ... | 1980 | 6161986 |
| shared antigenic determinants between brain and thymus-derived lymphocytes in dogs. | canine anti-canine myelin, canine distemper convalescent, and control sera were tested for the presence of antilymphocyte antibodies in a complement-dependent microcytotoxicity assay. sera were cytotoxic for ct 45-s cells, a canine origin thymic lymphoma, canine thymocytes, and phytomitogen-transformed canine peripheral blood lymphocytes. the cytotoxic effect was removed by absorption with canine white matter but not by absorption with galactocerebroside. the data suggests that the specificity o ... | 1981 | 6165219 |
| examination of the immunological relationship between measles virus and canine distemper virus using monospecific measles antisera. | indirect immunofluorescence titrations were performed with measles virus, the rockborn strain of canine distemper virus (cdv), and a large plaque variant of the onderstepoort strain of cdv (ond-lp) using monospecific antisera prepared against either the haemagglutinin (anti-ha), the haemolysin (anti-hl), or the ribonucleoprotein (anti-rnp) of measles virus. tests with anti-ha showed that the rockborn strain of cdv was more closely related to measles virus than ond-lp. the ribonucleoprotein antig ... | 1981 | 6165804 |
| potentiation of neurovirulence of canine distemper virus in guinea pigs by sensitization with neural antigen. | establishment of animal model of virus-induced encephalomyelitis was attempted in strain 13 guinea pigs sensitized with the homologous spinal cord antigen. intracerebral inoculation of canine distemper virus alone or sensitization with the neural antigen alone did not induce significant clinical signs. mild histological lesions were found in both the meninges and parenchyma of the central nervous system (cns) of virus-infected animals, and in the meninges of the sensitized ones. in contrast, com ... | 1981 | 6172611 |
| analysis of structural proteins of measles, canine distemper, and rinderpest viruses. | serological relationships among measles virus (mv), canine distemper virus (cdv), and rinderpest virus (rv), which constitute morbillivirus subgroup of paramyxoviridae, were investigated by immunoprecipitation and sds-polyacrylamide gel electrophoresis for their major structural proteins, i.e., hemagglutinin (h), nucleocapsid (nc), fusion (f), and matrix (m) proteins. the molecular weights of the four structural proteins of mv and cdv were confirmed to correspond to those previously reported by ... | 1981 | 6174760 |
| immunological and pathological findings in demyelinating encephalitis associated with canine distemper virus infection. | nine dogs with canine distemper encephalitis (cde) were examined with immunological techniques including demonstration of antibodies against canine distemper virus (cdv) in the serum and against myelin basic protein (mbp) in serum and in csf. mitogen stimulation tests of lymphocytes were also done. the brains were examined pathologically and immunoglobulin and c3 were demonstrated in lesions by means of immunohistological techniques. six dogs with acute cde had none or low antibody levels agains ... | 1982 | 6175160 |
| interferon in cerebrospinal fluid. a marker for viral persistence of canine distemper encephalomyelitis. | interferon (ifn) was measured in serum and cerebrospinal fluid (csf) of dogs after experimental (intranasal) infection with different strains of virulent canine distemper virus (cdv). viral strains employed produced neurological changes in dogs that range from acute inflammatory to subacute, delayed demyelinating encephalomyelitis. with few exceptions, first appearance of serum-ifn correlated with the first elevated body temperature 4 days post-infection (p.i.). by 16 days p.i. ifn had disappear ... | 1982 | 6180708 |
| antigenic drift in the course of subacute sclerosing panencephalitis (sspe). | neutralization kinetics study performed with measles virus and canine distemper virus (cdv) antigens revealed differences in the behaviour of antibodies contained in the cerebrospinal fluid (csf) samples from sspe patients. evident differences were observed both between samples from various patients and between csf samples collected from the same patient in the course of the disease. hyperimmune sera could be obtained in rabbits and guinea pigs by initial immunization with unpurified measles of ... | 1982 | 6183816 |
| antigen requirements and specificity of enzyme-linked immunosorbent assay for detection of canine igg against canine distemper viral antigens. | an enzyme-linked immunosorbent assay (elisa) was developed for detection of specific immunoglobulin g (igg) against canine distemper virus (cdv) antigens. sucrose gradient separation of viral and cellular proteins was required to produce coating antigens for the elisa. the specificity of the elisa was demonstrated by blocking cdv-positive canine sera with cdv-specific antisera produced in goats and rabbits and adsorption of positive sera with cdv antigens. a comparison of the elisa with the seru ... | 1982 | 6187248 |
| lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions. | eleven dogs were experimentally infected with canine distemper virus and studied for periods of up to 63 days post-inoculation. the responsiveness of lymphocytes in vitro toward phytohemagglutinin, myelin basic protein and galactocerebroside was tested at regular intervals during the course of infection by means of [3h]thymidine incorporation and flow cytometry. all dogs developed a marked decrease of lymphocyte responsiveness toward phytohemagglutinin. four dogs recovered rapidly from the immun ... | 1983 | 6187770 |
| glial proteins in canine distemper virus-induced demyelination. a sequential immunocytochemical study. | a temporal series of demyelinating lesions in experimental canine distemper virus (cdv) infection was examined with immunohistological techniques demonstrating myelin basic protein (mbp), myelin-associated glycoprotein (mag), and glial fibrillary acidic protein (gfap) on serial sections. the earliest lesions were characterized by decreased mbp and mag and increased gfap. during the further progression of the disease, mbp and mag losses continued to match each other. there was no indication of ma ... | 1983 | 6191513 |
| antibody responses to measles virus and canine distemper virus in multiple sclerosis. | age-matched serum and cerebrospinal fluid from 20 multiple sclerosis patients and 20 control patients with other neurological diseases were examined for antibodies to radiolabeled measles virus and canine distemper virus using an immunoprecipitation polyacrylamide gel technique. no evidence for reactivity to unique canine distemper virus-virion polypeptides in the multiple sclerosis group was obtained. competitive binding experiments with cerebrospinal fluid using labeled and unlabeled viral ant ... | 1983 | 6197006 |
| paramyxovirus and morbillivirus infections and their relationship to neurological disease. | | 1983 | 6198677 |
| immunological studies in demyelinating encephalitis associated with vaccinia virus and canine distemper virus infection. | | 1983 | 6198680 |
| viruses and demyelinating disease of the central nervous system. | in ms, there are many mechanisms by which viruses can produce demyelinating diseases in humans and experimental demyelinating infections in animals. | 1983 | 6209538 |
| mechanisms of in vitro immunosuppression in canine distemper virus infection. | the in vitro immunosuppressive effects of canine distemper virus (cdv) infection in gnotobiotic dogs was studied by co-culture of lymphocytes from those dogs with uninfected responder canine lymphocytes. lymphocytes from viremic dogs suppressed the phytomitogen responses of responder dogs. cell viability and total cells/ml in culture remained at or near control levels. the presence of immunofluorescence (if) positive syncytial cells in co-cultures was noted and their numbers were increased in cu ... | 1982 | 6215491 |
| persistent paramyxovirus infections and behaviour of beta-adrenergic receptors in c-6 rat glioma cells. | this paper describes the influence of persistent infections of c-6 rat glioma cells by paramyxoviruses [virus of subacute sclerosing panencephalitis (sspe) and canine distemper (cdv)] on the cellular beta-adrenergic membrane receptors. the number and binding properties of the beta-adrenergic receptors of the paramyxovirus-infected cells were measured by 3h-dihydroalprenolol binding studies and compared with those of the uninfected c-6 cells. in the case of sspe virus neither changes in number no ... | 1980 | 6245183 |
| multiple sclerosis and viruses: an overview. | the evidence for a viral etiology of ms has been reviewed. the strongest evidence favoring a virus is based primarily on epidemiologic considerations. less convincing evidence comes from pathologic studies, serology, lymphocyte reactivity to viral antigens, and reports of identification of virus in ms tissues. animal models of viral demyelination exist, which may provide insight into possible etiologic agents and pathogenetic mechanisms. considering all the data, it is clear that no agent can be ... | 1980 | 6248821 |
| influence of residual moisture and sealing atmosphere on viability of two freeze-dried viral vaccines. | this study demonstrated the complexity of the factors leading to changes in the infectivity titers of freeze-dried canine distemper and poultry infectious bronchitis viral vaccines. the change in moisture content during the storage period was an additional parameter which may influence the infectivity titer. the results emphasized the difficulty of predetermining variations in infectivity titers from the initial residual moisture. the analysis of the variations in infectivity titers during the s ... | 1980 | 6252243 |
| establishment of a canine cell line: derivation, characterization, and viral spectrum. | a cell line, designated a-72, for virus studies was established from a tumor surgically removed from a female, 8-year-old golden retriever dog. following explant culture, the cells were serially passaged 135 times. the a-72 cells maintained a fibroblastic appearance and, at the 123rd passage, had a population doubling time of approximately 27 hours. karyotypic analysis of the high passage cells showed the modal 2n chromosome number was 92 to 93. using starch gel electrophoresis for enzyme charac ... | 1980 | 6254399 |
| isolation of a paramyxovirus from the cerebrospinal fluid of a dog with posterior paresis. | a paramyxovirus was isolated from cerebrospinal fluid of a dog with a history of incoordination and posterior paresis. the virus apparently was not related to canine distemper virus (cdv), considering the lack of virus neutralization with cdv-specific antibody, negative immunofluorescence with cdv-specific conjugate, and avirulence for ferrets. the virus was antigenically related to a prototype strain of canine parainfluenza virus, as determined by positive immunofluorescence with canine parainf ... | 1980 | 6254938 |
| wellcome research: virology and the promotion of animal health. | | 1980 | 6259800 |
| time dependent decreases of maternal canine virus antibodies in newborn pups. | levels of passively transferred maternal antibodies to three canine viruses, rabies virus (rv), canine distemper virus (cdv) and infectious canine hepatitis (ich) virus, in serum specimens from 14 fetal pups and in serial serum specimens collected up to 45 days after whelping from 14 neonate pups were compared with levels of antibodies to these viruses in milk and sera collected concurrently from their respective dams. radioimmunoassays using rv-, cdv- and ich virus-specific antigens showed that ... | 1981 | 6262993 |
| prevalence of selected pathogenic microbial agents in the red fox (vulpes fulva) and gray fox (urocyon cinereoargenteus) of southwestern wisconsin. | free-ranging red foxes (vulpes fulva) and gray foxes (urocyon cinereoargenteus) were trapped in southwestern wisconsin. fox sera were tested to determine the prevalence of antibody for five different leptospira interrogans serovars, canine distemper virus (cdv), infectious canine hepatitis virus (ichv), and franciscella tularensis infections. grippotyphosa was the most prevalent leptospiral serovar antibody observed. twenty-five of 53 (47%) red foxes and 11 of 36 (31%) gray foxes had specific an ... | 1981 | 6265659 |
| canine viruses and multiple sclerosis. | serum and cerebrospinal fluid from multiple sclerosis (ms) patients and control subjects were tested and compared for presence and titer of neutralizing antibody against the most common canine viruses. canine viruses included canine distemper virus (cdv), canine adenovirus 1 (cav-1), canine parainfluenza virus (cpiv), canine herpesvirus (chv), canine coronavirus (ccv), and canine parvovirus (cpv). neutralizing titers against measles virus (mv) and human adenovirus 8 (ha8) were also tested. signi ... | 1981 | 6267515 |
| the immune system in slow disease due to persistent submicrobial (viral) infection. | | 1981 | 6270625 |
| viral antibody studies of laboratory dogs with diarrheal disease. | viral antibody studies were done on laboratory dogs in an epizootic of gastrointestinal disease. increased hemagglutination-inhibition antibody titers to a parvovirus (pv) antigenically related to feline panleukopenia virus were found in convalescent serum specimens of 78% (20/26) of the affected dogs and in 83% (5/6) of apparently healthy dogs. with one exception, all dogs tested had significant levels of hemagglutination-inhibition antibody to this pv. similar increased antibody titers were fo ... | 1981 | 6275746 |