| canine distemper virus clearance in chronic inflammatory demyelination. | the distribution of canine distemper virus (cdv) antigen was examined in the brains of 14 dogs with chronic nervous distemper using a monoclonal antibody against a major viral protein. in ten of these dogs, neutralizing anti-cdv antibody titers were determined in serum and unconcentrated cerebrospinal fluid (csf). in 19% of the inflammatory demyelinating lesions, large amounts of cdv antigen were found; in 34% of these lesions only residual traces of virus were seen and in almost half of the les ... | 1986 | 3825508 |
| canine distemper virus: in vivo virulence of in vitro-passaged persistent virus strains. | groups of ferrets were inoculated intraperitoneally with cell lysates or equivalent doses of whole cells from 9 different cell lines persistently infected with canine distemper virus. viral persistence in these cell lines was characterized by noncytolytic infection and restricted release of cell-free infectious virus. in vivo replication competency of the various viruses in ferrets ranged from nil to virulent and did not correlate with in vitro titers of inocula. ferret virulence (cell lysates o ... | 1987 | 3826861 |
| [possible involvement of the canine distemper virus in the epidemiology of multiple sclerosis]. | | 1985 | 3832280 |
| sequence homology within the morbilliviruses. | double-stranded cdna synthesized from total polyadenylate-containing mrna extracted from monkey kidney cells infected with canine distemper virus (cdv) was cloned into the psti site of escherichia coli plasmid pbr322. clones containing cdv dna were identified by hybridization to a cdv-specific 32p-labeled cdna. a cdna clone containing an insert 1,700 base pairs (cdv 364) has been identified as the reverse transcript of the mrna coding for the nucleocapsid protein. the size of the mrna species co ... | 1985 | 3838193 |
| cloning and characterization of dna complementary to the canine distemper virus mrna encoding matrix, phosphoprotein, and nucleocapsid protein. | double-stranded cdna synthesized from total polyadenylate-containing mrna, extracted from monkey kidney cells infected with canine distemper virus (cdv), has been cloned into the psti site of escherichia coli plasmid pbr322. clones containing canine distemper virus dna were identified by hybridization to a canine distemper virus-specific, 32p-labeled cdna. four specific clones containing different classes of sequences have been identified. the cloned plasmids contain inserts of 800 (clone 44-80) ... | 1985 | 3838194 |
| cdna cloning of the messenger rnas of five genes of canine distemper virus. | messenger rnas from vero cells infected with the onderstepoort strain of canine distemper virus (cdv) were cloned into the psti site of plasmid pat153. total polyadenylated rna was used and resulting clones were screened with 32p-labelled cdna probes from infected and mock-infected cells. the virus specificity of the clones was proven by northern blot hybridization and by ability to select radioactive virus mrnas labelled in vivo in the presence of actinomycin d. clones from the n, p and m genes ... | 1985 | 3838337 |
| [distemper in stone martens (martes foina, erxl.) in schleswig-holstein. a contribution to the epidemiology of distemper]. | | 1985 | 3891298 |
| canine distemper virus does not infect oligodendrocytes in vitro. | dissociated canine brain cell cultures were infected with virulent canine distemper virus (cdv). double immunofluorescent labelling was done to simultaneously demonstrate viral antigen and specific glial cell markers. virus containing oligodendrocytes were not found at any stage of the infection. a certain proportion of the infected cells were shown to be astrocytes. it was concluded that cdv has no obvious tropism for oligodendrocytes which could explain the mechanism of demyelination in distem ... | 1985 | 3897461 |
| studies on the intrathecal humoral immune response in canine distemper encephalitis. | albumin and igg were quantitated in paired cerebrospinal fluid (csf) and serum samples from dogs with demyelinating canine distemper virus (cdv) infection by means of rocket immunoelectrophoresis. the igg index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. specific antibodies against cdv and myelin were quantitated in csf and serum from 8 dogs with an elevated igg inde ... | 1986 | 3944250 |
| tyzzer's disease as a complication of canine distemper in a raccoon. | intercurrent canine distemper and tyzzer's disease were diagnosed in a mature raccoon (procyon lotor) submitted for necropsy. clinical, gross and microscopic findings characteristic of canine distemper virus (cdv), included ataxia, dyspnea, suppurative conjunctivitis, interstitial pneumonitis and generalized lymphocytolysis. inclusion bodies typical of cdv infection were present in many epithelial tissues. acute multifocal hepatic necrosis and acute segmental necrotizing enteritis were attribute ... | 1986 | 3951062 |
| requirement of methionine for the replication of canine distemper virus in vero cells. | the replication of canine distemper virus (cdv) in vero cells was found to require certain amino acids such as arginine, methionine and valine. the deprivation of methionine caused the most marked reduction in virus yield. in cells cultured in medium deprived of methionine, the early processes of viral replication such as adsorption, penetration and uncoating of virus occurred at normal rates, but the syntheses of viral rna and protein were markedly reduced. the addition of s-adenosylmethionine ... | 1985 | 3968535 |
| plaque identification of strand-forming canine distemper virus by staphylococcal protein a-mediated reverse passive haemadsorption. | the r252 neurotropic isolate of canine distemper virus (cdv) produces cytopathic effects (cpe) dominated by strand formation rather than by the formation of multinucleate giant cells. the lack of well-defined cpe and consequent rapid spread of infection throughout the cell monolayer has hindered plaque purification of this virus by conventional methods. however, the use of an immunological detection system which utilizes binding of hyperimmune dog serum to virus-infected cells, followed by the i ... | 1985 | 3980664 |
| declining incidence of multiple sclerosis in the orkney islands. | the incidence of ms in the orkney islands has been updated from 1941 to september 21, 1983. since 1965, ms incidence rates have fallen significantly when compared with those for 1941 to 1964. alterations in age-specific prevalence, mean duration of illness, and mean age of the ms population are consistent with the decline in incidence of ms in recent years. although the reason for the decreasing incidence is uncertain, it is consistent with the hypothesis that ms may be caused by canine distempe ... | 1985 | 3982640 |
| nonsuppurative meningoencephalomyelitis of unknown etiology in mink. | a central nervous system disease of mink occurred in three unrelated fur farms in oregon in september, 1981. only kits four to five months old were affected. clinical signs consisted of posterior ataxia progressing to complete posterior paralysis with loss of motor control and sensation. complete or partial recovery occurred in approximately 1.5 months in most mink. microscopic lesions consisted of severe nonsuppurative meningoencephalitis and meningomyelitis with vacuolation of the white matter ... | 1985 | 3984155 |
| the generation of small-plaque mutants during undiluted passage of canine distemper virus. | a culture of vero cells persistently infected with undiluted-passage, large-plaque canine distemper virus was found to release small-plaque virus (spv). this suggested that spv could be generated by large-plaque virus (lpv). however, attempts to induce small-plaque mutants from lpv with 5-fluorouracil resulted in the production of virus that expressed a variable plaque type and induced a spectrum of disease in hamsters. in contrast, small-plaque mutants, shown to arise during undiluted passage o ... | 1985 | 3988485 |
| thrombocytopenia associated with vaccination of a dog with a modified-live paramyxovirus vaccine. | thrombocytopenia (10,000/mm3), with hematochezia and melena, appeared in a dog 8 days after it was given modified-live canine distemper, virus vaccine and persisted for approximately 5 days. clinical investigation discounted other possible causes of thrombocytopenia; the condition was considered to be associated with vaccination. the problem spontaneously resolved. the appearance of thrombocytopenia after modified-live canine distemper virus vaccination is not unknown and may assume a severe for ... | 1985 | 4008307 |
| comparison of messenger rnas induced in cells infected with each member of the morbillivirus group. | virus-specific mrnas radiolabelled with [32p]orthophosphate in the presence of actinomycin d were extracted from the cytoplasm of vero cells infected with each of the known morbilliviruses: measles virus, canine distemper virus, rinderpest virus, and peste des petits ruminants virus. when analysed on denaturing agarose-formaldehyde gels the major rna species from all viruses in the group were identical, except for canine distemper virus where one of the virus-specific mrnas (mrna 5), which proba ... | 1985 | 4013082 |
| syncytia formation: an aid in the diagnosis of canine distemper encephalomyelitis. | syncytia formation has been observed in response to experimental canine distemper virus (cdv) infection in specific-pathogen-free beagle dogs. multinucleated giant cells are most frequently found in white matter lesions of the brain and in the anterior uvea of the eye. lymph nodes and the lung are occasionally positive, while the leptomeninges will also rarely harbour syncytia. the mechanism of syncytia formation and their possible importance in the pathogenesis of the disease are briefly discus ... | 1985 | 4031136 |
| epidemiological studies on multiple sclerosis. | | 1985 | 4033940 |
| effects of canine distemper virus on natural killer cell activity in dogs. | an in vitro 51cr-release assay was developed to detect the cytotoxicity of natural killer cells (nk) of canine peripheral blood mononuclear leukocytes to canine distemper virus (cdv) target cell membrane-bound antigens. leukocytes from 23 young (greater than or equal to 1 week of age), cdv-naive gnotobiotic dogs could discriminate between noninfected control and cdv-infected vero target cells. however, the amount of preinfection nk activity did not positively correlate with the ultimate outcome ... | 1985 | 4037509 |
| spread and distribution of viral antigen in nervous canine distemper. | canine distemper virus (cdv) antigen was demonstrated immunocytochemically in the central nervous system (cns) of 19 dogs killed from 16 to 170 days after infection. in the earliest lesions, infection of glial cells preceded demyelination, and the degree of myelin destruction correlated with the amount of viral antigen in the tissue. it was concluded that initial demyelination in distemper is directly viral-induced, but the nature of the infected glial cells remains uncertain. ependymal infectio ... | 1985 | 4050335 |
| encephalitis induced in non-human primates by canine distemper virus adapted to human neural cells. | the onderstepoort strain of canine distemper virus (cdv) adapted to human oligodendroglioma, neuroblastoma and glioblastoma cells, was intracerebrally inoculated into cynomolgus monkeys. all the three viruses caused periventricular encephalitis involving the brain stem. when the neurovirulence of these viruses were compared in terms of clinical signs and histopathological changes, the oligodendroglioma-adapted virus showed the neurovirulence of the highest degree inducing degeneration of axons a ... | 1985 | 4087464 |
| [distemper epidemic in switzerland: epidemiology and anamnesis of vaccination]. | | 1985 | 4089589 |
| ultrastructural features of canine distemper virus infection of the chorioallantoic membrane of the hen's egg. | | 1970 | 4099306 |
| ultrastructural features of canine distemper virus infection in a dog kidney cell line. | | 1971 | 4107529 |
| electron microscopic study of nuclear and nucleolar changes in cells infected with canine distemper virus (cdv). | | 1972 | 4112842 |
| further studies on the immunologic relationships among measles, distemper, and rinderpest viruses. | | 1974 | 4139195 |
| immunological study of the agent responsible for subacute sclerosing panencephalitis and biochemical characterization of measles antibody in subacute scelerosing panencephalitis. | | 1974 | 4141044 |
| characterization of a long-term suspension culture of the llc-mk monkey kidney cell line. | | 1974 | 4143485 |
| a post-vaccinal inclusion body encephalitis in dogs. | | 1974 | 4156617 |
| canine distemper virus in ferret, dog and bovine kidney cell cultures. | | 1965 | 4160642 |
| measles--canine distemper relationship. the effect of measles viruses and their influence on subsequent challenge with snyder hill distemper virus. | | 1966 | 4162470 |
| immunologic evidence of measles virus as an etiologic agent in subacute sclerosing panencephalitis. | | 1968 | 4170004 |
| [demonstration of distemper antigen in impression and section preparations using the fluorescent antibody technic]. | | 1967 | 4172561 |
| comparative immunofluorescent studies on measles, canine distemper, and rinderpest viruses. immunofluorescence of measles, distemper, and rinderpest viruses. | | 1970 | 4195094 |
| a microneutralization test for canine distemper virus. | | 1973 | 4201293 |
| presence of neutralizing antibody to canine distemper virus in sera of patients with subacute sclerosing panencephalitis. | | 1973 | 4201376 |
| ferritin-tagged antibody cross-reactions among rinderpest, canine distemper, and measles viruses. | | 1973 | 4201833 |
| comparative distemper vaccine titrations in ferrets and minks. | | 1973 | 4208099 |
| the nucleic acid type and effect of ph and hydroxylamine on canine distemper virus. | | 1968 | 4235309 |
| [presence of rheumatoid factors in antibacterial horse immune sera]. | | 1965 | 4285268 |
| [vaccination against canine distemper and infectious canine hepatitis. studies on efficacy and harmlessness]. | | 1965 | 4286204 |
| inactivation of viruses by benzalkonium chloride. | benzalkonium chloride (as roccal or zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, semliki forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 min of exposure at 30 c or at room temperature. poliovirus and encephalomyocarditis virus were not inactivated under the same conditions. it was concluded that all viruses tested were sensitive except members of the picorna group. the literature was reviewed ... | 1964 | 4288740 |
| combined viral and bacterial antigens for canine vaccines. | | 1966 | 4291220 |
| lack of interference in tissue culture between the viruses of canine distemper and infectious canine hepatitis as demonstrated by immunofluorescence. | | 1966 | 4291230 |
| additional data on measles virus antibody and antigen in subacute sclerosing panencephalitis. | | 1968 | 4295223 |
| potential antiviral agents. carbobenzoxy di- and tripeptides active against measles and herpes viruses. | | 1968 | 4295313 |
| terrapene heart (th-1), a continuous cell line from the heart of the box turtle terrapene carolina. | | 1967 | 4295486 |
| gas chromatography for detection of viral infections. | gas chromatograms of sertim extracts of dogs inoculated with canine infectious hepatitis virus showed two metabolites not observed in uninoculated animals. chromatograms of extracts of tissue cultures of dog kidney, inoculated with viruses causing canine hepatitis, herpes, and distemper, and a parainfluenza virus similar to simian virus-5, each showed two or more different metabolites. two of the distinguishing products from cultures inoculated with hepatitis virus were chromatographically indis ... | 1968 | 4295947 |
| canine distemper. | | 1967 | 4296185 |
| characteristics of cell culture systems. viral flora of canine tissues. | | 1968 | 4305426 |
| experience with an established cell line for veterinary vaccine production. | | 1968 | 4305440 |
| gas chromatographic detection of in vitro and in vivo activities of certain canine viruses. | | 1969 | 4307537 |
| isolation of viruses from primary dog cell cultures and the occurrence of viral antibody in donor animals. | | 1970 | 4313144 |
| myxoviruses and multiple sclerosis. | | 1969 | 4313660 |
| characterization of reptilian cell lines established at incubation temperatures of 23 to 36 degrees. | | 1970 | 4314147 |
| viral antibody patterns in laboratory dogs with respiratory disease. | | 1970 | 4314338 |
| presence of 2 different viral agents in brain cells of patients with subacute sclerosing panencephalitis. | | 1970 | 4316388 |
| continuous-flow ultracentrifugation of canine distemper virus and infectious canine hepatitis virus. | the use of a spinco l-4 zonal centrifuge with the b-xvi continuous-flow rotor for the purification of canine distemper and infectious canine hepatitis viruses is described. up to 68 liters of virus was processed at one time. infectious canine hepatitis virus was found to band at 39% sucrose and canine distemper virus banded between 32 and 48% sucrose. the virus was concentrated 10-fold, and the purity of the virus, as measured by protein concentration, was increased by 99%. | 1970 | 4320861 |
| ultrastructural nature of canine distemper inclusions in the urinary bladder. | | 1970 | 4328310 |
| the effect of a carbobenzoxy tripeptide on the biological activities of measles virus. | | 1971 | 4332971 |
| inhibition of cell fusion by local anaesthetics and tranquillizers. | | 1972 | 4338830 |
| inhibition of virus-induced cell fusion by local anaesthetics and phenothiazine tranquilizers. | | 1972 | 4340281 |
| synopsis of vaccination procedures for dogs. | | 1973 | 4345835 |
| development of hip dysplasia in dogs. | | 1973 | 4346059 |
| demonstration by electron microscopy of viruses in cells found by light microscopy to contain inclusion bodies. | | 1972 | 4346228 |
| viral infections and demyelinating diseases. | | 1973 | 4348989 |
| karyological characterization of primary dog kidney cells in regard to acceptability of the cells as substrate of virus vaccines. | | 1972 | 4349818 |
| the role of lysosomes in virus-induced cell fusion. 2. modification of the cell surface. | | 1971 | 4354974 |
| the role of lysosomes in virus-induced cell fusion. 1. cytochemical studies. | | 1971 | 4354975 |
| cell surface changes in virus-induced cell fusion. 2. changes in cell coat thickness. | | 1971 | 4355100 |
| polypeptide composition of measles and canine distemper viruses. | | 1973 | 4355119 |
| immunogenicity of canine distemper virus vaccine produced in a continuous cell line (llc-mk2 cells). | | 1973 | 4355770 |
| recent advances in canine virus research. | | 1973 | 4356887 |
| simultaneous administration of dichlorvos anthelmintic and modified live virus vaccines to puppies. | | 1974 | 4365765 |
| the ultrastructure of cytoplasmic inclusions in circulating lymphocytes in canine distemper. | | 1974 | 4371726 |
| serological indication of canine distemper and of infectious canine hepatitis in wolves (canis lupus l.) in northern canada. | | 1974 | 4373585 |
| measles, canine distemper and respiratory syncytial virions and nucleocapsids. a comparative study of their structure, polypeptide and nucleic acid composition. | | 1974 | 4374646 |
| canine respiratory virus infections. | | 1974 | 4375231 |
| synergism between respiratory viruses and bacteria. | | 1968 | 4386279 |
| experimental canine distemper virus-induced demyelination. | | 1974 | 4413368 |
| isolation and comparative study of the nucleocapsids of measles and canine distemper viruses from infected cells. | | 1974 | 4414005 |
| epizootic of canine distemper virus infection among urban raccoons and gray foxes. | | 1974 | 4436928 |
| demyelinating activity of canine distemper virus isolates in gnotobiotic dogs. | | 1974 | 4443615 |
| a comparison between virion rna of measles virus and some other paramyxoviruses. | | 1974 | 4444688 |
| combined distemper-measles vaccine: advantage or disadvantage? | | 1974 | 4450411 |
| the ultrastructure of inclusions in blood cells of dogs with distemper. | | 1974 | 4457569 |
| the protecting capacity of neutralizing antibodies by distemper virus infections in mink. | | 1972 | 4509393 |
| subacute sclerosing panencephalitis. transmission of the virus to calves and lambs. | | 1972 | 4563450 |
| myelin-specific autoantibodies associated with central nervous system demyelination in canine distemper virus infection. | sera from dogs with spontaneously occurring and experimentally produced canine distemper virus-associated demyelinating encephalitis were examined for antibodies to central nervous system myelin by the complement fixation and indirect immunofluorescent methods. complement-fixing immunoglobulin m antibodies and non-complement-fixing immunoglobulin g antibodies were found in 97% of the spontaneous cases. in comparison, only 28% of control sera contained these antibodies; furthermore, mean antibody ... | 1973 | 4584054 |
| studies of old dog encephalitis. ii. electron microscopic and immunohistologic findings. | | 1973 | 4588526 |
| canine distemper: current concepts in laboratory and clinical diagnosis. | | 1974 | 4593536 |
| canine distemper virus in domesticated cats and pigs. | | 1974 | 4600776 |
| evidence for transplacental transmission of canine distemper virus: two case reports. | | 1974 | 4607990 |
| [demonstration of antibodies precipitating an antigen of carrés disease virus in the serum of patients with less]. | | 1972 | 4624805 |
| [experimental study of several strains of the virus of carré's disease in dogs. identification and definition of variant strains]. | | 1972 | 4632950 |
| enzyme activities associated with the demyelinating phase of canine distemper. i. beta-glucuronidase, acid and neutral proteinases. | | 1972 | 4643260 |
| cell fusion by canine distemper virus-infected cells. | av3 cells (continuous human amnion) infected with the onderstepoort strain of canine distemper virus produced cell fusion within 2 to 5 hr when added to av3 cell monolayers. an apparent requirement for intact, infected cells was demonstrated by showing that (i) frozen-and-thawed infected cells failed to induce fusion, (ii) infected cells frozen in the presence of glycerol retained their ability to induce fusion, (iii) infected cells subjected to swelling in hypotonic buffer and homogenization lo ... | 1972 | 4644630 |
| affinity for retinal pigment epithelium by certain viruses. | | 1973 | 4684263 |
| recovery of viruses in chronic cns disease. | | 1973 | 4718044 |