Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| horizontal and vertical transmission of west nile virus genotype ny99 by culex salinarius and genotypes ny99 and wn02 by culex tarsalis. | culex tarsalis is a superior horizontal and vertical vector of west nile virus (wnv) compared with culex salinarius. culex salinarius transmitted wnv genotype ny99 (ct 2741-99 strain) horizontally to suckling mice at significantly lower rates than cx. tarsalis on days 8, 9, 10, and 12 post-infection, and cx. salinarius transmitted wnv genotype ny99 to offspring at a lower vertical transmission infection rate than cx. tarsalis. culex tarsalis transmitted wnv genotypes ny99 and wn02 (ct s0084-08 s ... | 0 | 22232464 |
| presumed case of "stiff-horse syndrome" caused by decreased gamma-aminobutyric acid (gaba) production in an american paint mare. | glutamic acid decarboxylase (gad) converts glutamic acid into the inhibitory neurotransmitter γ-aminobutyric acid (gaba). increased serum gad (auto) antibody concentrations were found in a mare with increased postural musculature tone resulting in stiffness and recumbence. the mare was treated with dexamethasone which resulted in resolution of clinical signs and decreased gad antibody concentrations. | 0 | 22753968 |
| a rare case of severe acute hepatitis associated with adult-onset still disease dramatically improved by high-dose steroid therapy. | 0 | 22347827 | |
| enhancing the teaching of evolution in public health. | public health courses are emerging as popular undergraduate offerings, especially at universities with schools of public health. it is important to note that evolution has shaped the burden of disease in the modern world in which we practice and educate for public health. human cultures and technologies have modified life on planet earth and have co-evolved with myriad other species, including microorganisms, plant and animal sources of food, invertebrate vectors of disease, and intermediate bir ... | 0 | 25221636 |
| the double-edged sword: how evolution can make or break a live-attenuated virus vaccine. | even students who reject evolution are often willing to consider cases in which evolutionary biology contributes to, or undermines, biomedical interventions. moreover the intersection of evolutionary biology and biomedicine is fascinating in its own right. this review offers an overview of the ways in which evolution has impacted the design and deployment of live-attenuated virus vaccines, with subsections that may be useful as lecture material or as the basis for case studies in classes at a va ... | 0 | 22468165 |
| seroepidemiologic screening for zoonotic viral infections, maputo, mozambique. | 0 | 27088316 | |
| histopathologic and molecular characterization of sarcocystis calchasi encephalitis in white-winged doves ( zenaida asiatica ) and eurasian collared doves ( streptopelia decaocto ), east-central texas, usa, 2010-13. | sarcocystis calchasi is a recently described apicomplexan parasite that causes encephalitis in avian hosts. we diagnosed one white-winged dove ( zenaida asiatica ) and two eurasian collared doves ( streptopelia decaocto ) in texas, us, with a history of neurologic signs with protozoal encephalitis. on histologic examination, all three doves had moderate to severe meningoencephalitis characterized by large numbers of plasma cells, lymphocytes, and macrophages with gliosis and astrocytosis. brain ... | 0 | 27124332 |
| role of metabolism during viral infections, and crosstalk with the innate immune system. | viruses have been for long polemic biological particles which stand in the twilight of being living entities or not. as their genome is reduced, they rely on the metabolic machinery of their host in order to replicate and be able to continue with their infection process. the understanding of their metabolic requirements is thus of paramount importance in order to develop tailored drugs to control their population, without affecting the normal functioning of their host. new advancements in high t ... | 0 | 27195191 |
| severe neuroinvasive west nile virus infection in a child with undiagnosed addison's disease. | 0 | 25133095 | |
| volatile phytochemicals as mosquito semiochemicals. | plant biochemical processes result in the release of an array of volatile chemical substances into the environment, some of which are known to play important plant fitness enhancing functions, such as attracting pollinators, thermal tolerance of photosynthesis, and defense against herbivores. cunningly, phytophagous insects have evolved mechanisms to utilize these volatiles to their own advantage, either to colonize a suitable host for feeding, reproduction and oviposition or avoid an unsuitable ... | 0 | 25383131 |
| regulatory t-cell homeostasis: steady-state maintenance and modulation during inflammation. | regulatory t (treg) cells play a vital role in the prevention of autoimmunity and the maintenance of self-tolerance, but these cells also have an active role in inhibiting immune responses during viral, bacterial, and parasitic infections. although excessive treg activity can lead to immunodeficiency, chronic infection, and cancer, too little treg activity results in autoimmunity and immunopathology and impairs the quality of pathogen-specific responses. recent studies have helped define the hom ... | 0 | 24712458 |
| modelling diseases with relapse and nonlinear incidence of infection: a multi-group epidemic model. | in this paper, we introduce a basic reproduction number for a multi-group sir model with general relapse distribution and nonlinear incidence rate. we find that basic reproduction number plays the role of a key threshold in establishing the global dynamics of the model. by means of appropriate lyapunov functionals, a subtle grouping technique in estimating the derivatives of lyapunov functionals guided by graph-theoretical approach and lasalle invariance principle, it is proven that if it is les ... | 0 | 24963980 |
| neutrophils recruited by il-22 in peripheral tissues function as trail-dependent antiviral effectors against mcmv. | during primary infection, murine cytomegalovirus (mcmv) spreads systemically, resulting in virus replication and pathology in multiple organs. this disseminated infection is ultimately controlled, but the underlying immune defense mechanisms are unclear. investigating the role of the cytokine il-22 in mcmv infection, we discovered an unanticipated function for neutrophils as potent antiviral effector cells that restrict viral replication and associated pathogenesis in peripheral organs. nk-, nkt ... | 0 | 24721575 |
| bilateral diaphragmatic paralysis in an hiv patient: second reported case and literature review. | human immunodeficiency virus (hiv) disease is widespread all over the world, and the neurological and respiratory complications have been described previously. peripheral neuropathy is one of the commonest neurological complications of the hiv infection. in this report we describe a hiv positive male smoker who was admitted to the hospital because of community acquired pneumonia. bilateral diaphragmatic paralysis was diagnosed for which no other cause was found and was attributed to the hiv infe ... | 0 | 24778479 |
| opsoclonus myoclonus syndrome: an unusual presentation for west nile virus encephalitis. | a record number of west nile virus (wnv) cases and fatalities seen in 2012 have brought to light the numerous manifestations of neuroinvasive disease. we report a case of opsoclonus myoclonus syndrome attributed to wnv and its clinical course after treatment with a combination of steroids and intravenous immunoglobulin. our objective is to highlight opsoclonus myoclonus syndrome as a potential manifestation of wnv encephalitis. | 0 | 24688189 |
| neurotropic t-cell-rich b-cell lymphoma in a 14-year-old morgan gelding. | a 14-year-old morgan gelding was presented for progressive weakness and muscle atrophy. the horse was initially diagnosed with equine protozoal myelitis based on history, physical examination, and laboratory diagnostics. despite therapy, the horse declined clinically and was euthanized. necropsy revealed a rare form of neurotropic lymphoma, described in this report. | 0 | 24688140 |
| urgent care providers' knowledge and attitude about public health reporting and pertussis control measures: implications for informatics. | we assessed urgent care providers' knowledge about public health reporting, guidelines, and actions for the prevention and control of pertussis; attitudes about public health reporting and population-based data; and perception of reporting practices in their clinic. | 0 | 19823151 |
| boundaries and overlap: community medicine or public health doctors and primary care physicians. | to explore the boundaries and overlap of practice profiles of primary care physicians (pcps), including fps and gps, and community medicine specialists (cms), particularly in the area of community-oriented clinical care. | 0 | 19910598 |
| malaria diagnosis by a polymerase chain reaction-based assay using a pooling strategy. | pooling clinical specimens reduces the number of assays needed when screening for infectious diseases. polymerase chain reaction (pcr)-based assays are the most sensitive tests to diagnose malaria, but its high cost limits its use. we adapted a pooling platform that could reduce the number of assays needed to detect malaria infection. to evaluate this platform, two sets of 100 serum samples, with 1% and 5% malaria prevalence, were tested. dna, extracted from pooled samples, was amplified by mala ... | 0 | 19861605 |
| veterinary medical ethics. an ethicist's commentary on veterinarians and production diseases. | 0 | 20119536 | |
| sentinel symptoms of climate change: indicators for related health effects. | 0 | 20049107 | |
| genomic screening with rnai: results and challenges. | rna interference (rnai) is an effective tool for genome-scale, high-throughput analysis of gene function. in the past five years, a number of genome-scale rnai high-throughput screens (htss) have been done in both drosophila and mammalian cultured cells to study diverse biological processes, including signal transduction, cancer biology, and host cell responses to infection. results from these screens have led to the identification of new components of these processes and, importantly, have also ... | 0 | 20367032 |
| oncolytic herpes simplex virus 1 (hsv-1) vectors: increasing treatment efficacy and range through strategic virus design. | viruses have long been considered potential anticancer treatments. wild-type viruses have been tested as anticancer agents in clinical trials since the 1960s. the possibility of viral oncolysis as an alternate cancer therapy was transformed by the emergence of modern genetic engineering. the herpes simplex virus (hsv) family offers particular advantages for use as a viral oncolytic. the engineered vectors that make up oncolytic hsvs (ohsvs) have demonstrated remarkable safety in clinical trials, ... | 0 | 22287818 |
| unified data resource for cryo-em. | three-dimensional (3d) cryoelectron microscopy reconstruction methods are uniquely able to reveal structures of many important macromolecules and macromolecular complexes. emdatabank.org, a joint effort of the protein databank in europe (pdbe), the research collaboratory for structural bioinformatics (rcsb), and the national center for macromolecular imaging (ncmi), is a "one-stop shop" resource for global deposition and retrieval of cryo-em map, model, and associated metadata. the resource unif ... | 0 | 20888470 |
| community-driven standards-based electronic laboratory data-sharing networks. | public health laboratories (phls) are critical components of the nation's healthcare system, serving as stewards of valuable specimens, delivering important diagnostic results to support clinical and public health programs, supporting public health policy, and conducting research. this article discusses the need for and challenges of creating standards-based data-sharing networks across the phl community, which led to the development of the phl interoperability project (phlip). launched by the a ... | 0 | 20521375 |
| the state public health laboratory system. | this article describes the development since 2000 of the state public health laboratory system in the united states. these state systems collectively are related to several other recent public health laboratory (phl) initiatives. the first is the core functions and capabilities of state public health laboratories, a white paper that defined the basic responsibilities of the state phl. another is the centers for disease control and prevention national laboratory system (nls) initiative, the goal ... | 0 | 20521374 |
| traditions, transitions, and transfats: new directions for public health. | 0 | 20402191 | |
| chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. | there are several molecular entities common to the immune and nervous systems. salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobiology. this review limns several illustrative examples and presents general principles of chemokine action that are manifest in both systems. these include the following: (1) chemokines tend equally to arrest cells and to make them move, in the process of positioning target cells with sp ... | 0 | 19836265 |
| peripheral coding of taste. | five canonical tastes, bitter, sweet, umami (amino acid), salty, and sour (acid), are detected by animals as diverse as fruit flies and humans, consistent with a near-universal drive to consume fundamental nutrients and to avoid toxins or other harmful compounds. surprisingly, despite this strong conservation of basic taste qualities between vertebrates and invertebrates, the receptors and signaling mechanisms that mediate taste in each are highly divergent. the identification over the last two ... | 0 | 24607224 |
| automated image-based phenotypic analysis in zebrafish embryos. | presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. zebrafish embryos are amenable to automation necessary for high-throughput chemical screens, and optical transparency makes them potentially suited for image-based screening. however, the lack of tools for automated analysis of complex images presents an obstacle to using the zebrafish as a high-throughput screening model. we have developed an automated system for imaging and analyzing ... | 0 | 19235725 |
| reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. | aging is associated with a progressive decline in immune function (immunosenescence) resulting in an increased susceptibility to viral and bacterial infections. here we show reduced expression of toll-like receptor 1 (tlr1) in polymorphonuclear leukocytes (pmn) and an underlying age-dependent deficiency in pmn bioenergetics. in older (>65 years) adults, stimulation through tlr1 led to lower activation of integrins (cd11b and cd18), lower production of the chemokine il-8, and lower levels of the ... | 0 | 24595889 |
| virus-inactivated plasma - plasmasafe: a one-year experience. | fresh-frozen plasma (ffp) is a widely used blood transfusion product. the transfusion safety of this product is ensured by legally obligatory tests, but can be further improved by using some technical procedures, such as methylene blue (mb) and solvent-detergent (sd) viral inactivation methods. mainly organisational criteria led us to introduce the sd viral inactivation technique as a service activity. in this report we describe our first year of experience, following the introduction of the sd ... | 0 | 19204766 |
| collaboration addresses information and education needs of an urban public health workforce. | 0 | 17641775 | |
| building better connections: the national library of medicine and public health. | the paper describes the expansion of the public health programs and services of the national library of medicine (nlm) in the 1990s and provides the context in which nlm's public health outreach programs arose and exist today. | 0 | 17641764 |
| blood transfusion for the treatment of acute anaemia in inflammatory bowel disease and other digestive diseases. | allogeneic blood transfusion (abt) is frequently used as the first therapeutic option for the treatment of acute anaemia in patients with inflammatory bowel disease (ibd), especially when it developed due to gastrointestinal or perioperative blood loss, but is not risk-free. adverse effects of abt include, but are not limited to, acute hemolytic reaction (wrong blood or wrong patient), febrile non-hemolytic transfusional reaction, bacterial contamination, transfusion-related acute lung injury, t ... | 0 | 19787832 |
| novel hmgb1-inhibiting therapeutic agents for experimental sepsis. | sepsis refers to a systemic inflammatory response syndrome resulting from a microbial infection. the inflammatory response is partly mediated by innate immune cells (such as macrophages, monocytes, and neutrophils), which not only ingest and eliminate invading pathogens but also initiate an inflammatory response by producing early (e.g., tnf and ifn-gamma) and late (e.g., high-mobility group box [hmgb1]) proinflammatory cytokines. here, we briefly review emerging evidence that support extracellu ... | 0 | 19333143 |
| inflammatory choroidal neovascularization. | choroidal neovascularization (cnv) can be a severe sight-threatening sequela, which can be secondary to both infectious and noninfectious uveitis. this review summarizes the different diseases associated with cnv, highlighting new treatment modalities and the possible strategies, which could be applied for the therapy of this occurrence. | 0 | 20404991 |
| differential diagnosis of retinal vasculitis. | retinal vaculitis is a sight-threatening inflammatory eye condition that involves the retinal vessels. detection of retinal vasculitis is made clinically, and confirmed with the help of fundus fluorescein angiography. active vascular disease is characterized by exudates around retinal vessels resulting in white sheathing or cuffing of the affected vessels. in this review, a practical approach to the diagnosis of retinal vasculitis is discussed based on ophthalmoscopic and fundus fluorescein angi ... | 0 | 20404987 |
| zika--how fast does this virus mutate? | the world health organization has declared the present zika virus epidemic to be a 'public health emergency of international concern'. the virus appears to have spread from thailand to french polynesia in 2013, and has since infected over a million people in the countries of south and central america. in most cases the infection is mild and transient, but the virus does appear to be strongly neurotropic and the presumptive cause of both birth defects in fetuses and guillain-barré syndrome in som ... | 0 | 27029869 |
| right lobe living-donor hepatectomy-the toronto approach, tips and tricks. | living-donor liver transplantation (ldlt) is a well-established treatment for end-stage liver disease. nevertheless, it has not been extensively accepted in north america or europe as it has been in asia. at the university of toronto we initiated our ldlt program in 2000 and since then our program has grown each year, representing today the largest ldlt program in north america. our right-lobe ldlt experience from 2000-2014 includes 474 right lobes. only 30% of our grafts have included the middl ... | 0 | 27115005 |
| integrative approach for a transformative freshman-level stem curriculum. | in 2014 wesley college adopted a unified undergraduate program of evidence-based high-impact teaching practices. through foundation and federal and state grant support, the college completely revised its academic core curriculum and strengthened its academic support structures by including a comprehensive early alert system for at-risk students. in this core, science, technology, engineering, and mathematics (stem) faculty developed fresh manifestations of integrated concept-based introductory c ... | 0 | 27064213 |
| history, epidemiology, and clinical manifestations of zika: a systematic review. | to describe salient epidemiological characteristics of zika virus outbreaks across the world and to examine the clinical presentations, complications, and atypical manifestations related to their occurrence in recent history. | 0 | 26959260 |
| zika virus: anatomy of a global health crisis. | zika virus infection has emerged as the world's newest health threat, linked to microcephaly in infants and guillain-barré syndrome in adults. we address the rapid global spread of this disease, and the prospects for successful prevention and treatment. | 0 | 27069344 |
| determinants and drivers of infectious disease threat events in europe. | infectious disease threat events (idtes) are increasing in frequency worldwide. we analyzed underlying drivers of 116 idtes detected in europe during 2008-2013 by epidemic intelligence at the european centre of disease prevention and control. seventeen drivers were identified and categorized into 3 groups: globalization and environment, sociodemographic, and public health systems. a combination of >2 drivers was responsible for most idtes. the driver category globalization and environment contri ... | 0 | 26982104 |
| encephalitis, ontario, canada, 2002-2013. | encephalitis, a brain inflammation leading to severe illness and often death, is caused by >100 pathogens. to assess the incidence and trends of encephalitis in ontario, canada, we obtained data on 6,463 ontario encephalitis hospitalizations from the hospital discharge abstract database for april 2002-december 2013 and analyzed these data using multiple negative binomial regression. the estimated crude incidence of all-cause encephalitis in ontario was ≈4.3 cases/100,000 persons/year. incidence ... | 0 | 26890626 |
| comparative analysis of liver injury-associated cytokines in acute hepatitis a and b. | acute hepatitis a (aha) and acute hepatitis b (ahb) are caused by an acute infection of the hepatitis a virus and the hepatitis b virus, respectively. in both aha and ahb, liver injury is known to be mediated by immune cells and cytokines. in this study, we measured serum levels of various cytokines and t-cell cytotoxic proteins in patients with aha or ahb to identify liver injury-associated cytokines. | 0 | 26996565 |
| updates on communicable and non-communicable diseases in lmics. | 0 | 27358652 | |
| seasonal abundance and molecular identification of west nile virus vectors, culex pipens and culex quinquefasciatus (diptera: culicidae) in abeokuta, south-west, nigeria. | west nile virus (wnv) infection, is an arbovirus infection with high morbidity and mortality, the vector responsible for both human and animal transmission is culex pipens complex. | 0 | 27358624 |
| zika virus: a global threat to humanity: a comprehensive review and current developments. | at present, one of greatest concerns of medical personnel is zika virus (zikv). though it has been reported for quite a long time, its rapid emergence, new modes of transmission, and more importantly, the congenital anomalies associated with it have made the situation worse. it was first detected in 1947. after that, this infection was found in the countries of africa as well as asia. at present, interestingly it has been reported from brazil. microcephaly and intracranial calcification have bee ... | 0 | 27114968 |
| vectorborne infections, mali. | 0 | 26812625 | |
| role of immune aging in susceptibility to west nile virus. | west nile virus (wnv) can cause severe neuroinvasive disease in humans and currently no vaccine or specific treatments are available. as aging is the most prominent risk factor for wnv, age-related immune dysregulation likely plays an essential role in host susceptibility to infection with wnv. in this review, we summarize recent findings in effects of aging on immune responses to wnv infection. in particular, we focus on the age-dependent dysregulation of innate immune cell types-neutrophils, m ... | 0 | 27188562 |
| diabetes, epstein-barr virus and extranodal natural killer/t-cell lymphoma in india: unravelling the plausible nexus. | the international diabetes federation diabetes atlas estimates a staggering 590 million people affected with diabetes mellitus (dm) within the next two decades globally, of which type 2 dm will constitute more than 90%. the associated insulin resistance, hyperinsulinemia, and hyperglycemia pose a further significant risk for developing diverse malignant neoplasms. diabetes and malignancy are multifactorial heterogeneous diseases. the immune dysfunction secondary to type 2 diabetes also reactivat ... | 0 | 27051150 |
| progressive encephalomyelitis with rigidity and myoclonus (perm): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab. | 0 | 26788132 | |
| host restriction factors for hepatitis c virus. | host-hepatitis c virus (hcv) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. these findings are illustrated by the recent discovery of host-encoded factors that restrict hcv infection. in this review, we briefly discuss these restriction factors in different steps of hcv infection. in each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit hcv infection ... | 0 | 26819515 |
| cholesterol-enriched domain formation induced by viral-encoded, membrane-active amphipathic peptide. | the α-helical (ah) domain of the hepatitis c virus nonstructural protein ns5a, anchored at the cytoplasmic leaflet of the endoplasmic reticulum, plays a role in viral replication. however, the peptides derived from this domain also exhibit remarkably broad-spectrum virocidal activity, raising questions about their modes of membrane association. here, using giant lipid vesicles, we show that the ah peptide discriminates between membrane compositions. in cholesterol-containing membranes, peptide b ... | 0 | 26745420 |
| amino acid catabolism: a pivotal regulator of innate and adaptive immunity. | enhanced amino acid catabolism is a common response to inflammation, but the immunologic significance of altered amino acid consumption remains unclear. the finding that tryptophan catabolism helped maintain fetal tolerance during pregnancy provided novel insights into the significance of amino acid metabolism in controlling immunity. recent advances in identifying molecular pathways that enhance amino acid catabolism and downstream mechanisms that affect immune cells in response to inflammatory ... | 0 | 22889220 |
| virus evolution and transmission in an ever more connected world. | the frequency and global impact of infectious disease outbreaks, particularly those caused by emerging viruses, demonstrate the need for a better understanding of how spatial ecology and pathogen evolution jointly shape epidemic dynamics. advances in computational techniques and the increasing availability of genetic and geospatial data are helping to address this problem, particularly when both information sources are combined. here, we review research at the intersection of evolutionary biolog ... | 0 | 26702033 |
| understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach. | annual vaccination against seasonal influenza is recommended to decrease disease-related mortality and morbidity. however, one population that responds suboptimally to influenza vaccine is adults over the age of 65 years. the natural aging process is associated with a complex deterioration of multiple components of the host immune system. research into this phenomenon, known as immunosenescence, has shown that aging alters both the innate and adaptive branches of the immune system. the intricate ... | 0 | 23002979 |
| dengue in the context of "safe blood" and global epidemiology: to screen or not to screen? | 0 | 22882092 | |
| evaluation of a rapid analyte measurement platform for west nile virus detection based on united states mosquito control programs. | the rapid analyte measurement platform (ramp) system is an immunoassay test for west nile virus (wnv) detection. although reverse transcriptase-polymerase chain reaction (rt-pcr) methodology has been regarded as the gold standard for confirming wnv presence, usage of ramp testing kits has increased in the past years. we collected ramp test result data that were subsequently confirmed with rt-pcr methodology from mosquito control agencies to evaluate the efficacy of the ramp testing. results indi ... | 0 | 22855771 |
| infectious disease transmission during organ and tissue transplantation. | infectious disease transmission through organ and tissue transplantation has been associated with severe complications in recipients. determination of donor-derived infectious risk associated with organ and tissue transplantation is challenging and limited by availability and performance characteristics of current donor epidemiologic screening (e.g., questionnaire) and laboratory testing tools. common methods and standards for evaluating potential donors of organs and tissues are needed to facil ... | 0 | 22840823 |
| solid organ transplant-associated lymphocytic choriomeningitis, united states, 2011. | three clusters of organ transplant-associated lymphocytic choriomeningitis virus (lcmv) transmissions have been identified in the united states; 9 of 10 recipients died. in february 2011, we identified a fourth cluster of organ transplant-associated lcmv infections. diabetic ketoacidosis developed in the organ donor in december 2010; she died with generalized brain edema after a short hospitalization. both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplan ... | 0 | 22839997 |
| rhodococcus erythropolis encephalitis in patient receiving rituximab. | 0 | 22840370 | |
| cytomegalovirus impairs antiviral cd8+ t cell immunity by recruiting inflammatory monocytes. | inflammatory monocytes are key early responders to infection that contribute to pathogen-host interactions in diverse ways. here, we report that the murine cytomegalovirus-encoded cc chemokine, mck2, enhanced ccr2-dependent recruitment of these cells to modulate antiviral immunity, impairing virus-specific cd8(+) t cell expansion and differentiation into effector cytotoxic t lymphocytes, thus reducing the capacity to eliminate viral antigen-bearing cells and slowing viral clearance. adoptive tra ... | 0 | 22840843 |
| regulation of b-cell responses by toll-like receptors. | the discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. twenty-three years after janeway first outlined the fundamental concepts of the 'pattern recognition' model, and 15 years since the identification of toll-like receptors (tlrs) as pattern recognition receptors (prrs), new insights continue to be reveale ... | 0 | 22444240 |
| chapter 4: red cell transfusion to treat anemia in ckd. | 0 | 25018951 | |
| clinical reasoning: agitation and psychosis in a patient after renal transplantation. | 0 | 22851723 | |
| expanding the targets available to therapeutic antibodies via novel disease-specific markers. | the development of immunotherapies offers significant promise for clinical applications in cancer and infectious diseases. here the authors describe a novel, integrated approach to immunotherapy that combines novel technologies to discover and target disease-specific peptide/hla class i complexes. this unique class of markers makes the entire proteome accessible to antibody reagents and offers unsurpassed specificity for targeting cancerous and infected cells. arm one of the three-armed approach ... | 0 | 22053971 |
| temporal bone findings in a case of susac's syndrome. | to describe the histopathologic findings in the temporal bones of a patient with susac's syndrome (ss). | 0 | 21897318 |
| review and assessment of the american society of tropical medicine and hygiene travel awards program, 1991-2010. | during 1991-2010, 456 persons from 62 countries were provided financial support to attend the annual meeting of the american society of tropical medicine and hygiene. winners came from 17 african, 16 asia-pacific, 14 latin american and caribbean, and 13 european and middle eastern countries, and from canada and the united states. virtually equal numbers of awards were offered to women and men. winners were selected from u.s. academic centers (30%), foreign universities (26%), international cente ... | 0 | 21896796 |
| a consensus statement for safety monitoring guidelines of treatments for major depressive disorder. | this paper aims to present an overview of screening and safety considerations for the treatment of clinical depressive disorders and make recommendations for safety monitoring. | 0 | 21888608 |
| estimating the economic impact of a possible equine and human epidemic of west nile virus infection in belgium. | this study aimed at estimating, in a prospective scenario, the potential economic impact of a possible epidemic of wnv infection in belgium, based on 2012 values for the equine and human health sectors, in order to increase preparedness and help decision-makers. modelling of risk areas, based on the habitat suitable for culex pipiens, the main vector of the virus, allowed us to determine equine and human populations at risk. characteristics of the different clinical forms of the disease based on ... | 0 | 27526394 |
| miscarriage following dengue virus 3 infection in the first six weeks of pregnancy of a dengue virus-naive traveller returning from bali to italy, april 2016. | we report miscarriage following dengue virus (denv)-3 infection in a pregnant woman returning from bali to italy in april 2016. on her arrival, the woman had fever, rash, asthenia and headache. denv rna was detected in plasma and urine samples collected the following day. six days after symptom onset, she had a miscarriage. denv rna was detected in fetal material, but in utero fetal infection cannot be demonstrated due to possible contamination by maternal blood. | 0 | 27526349 |
| geographic variation of photoperiodic diapause but not adult survival or reproduction of the invasive mosquito aedes albopictus (diptera: culicidae) in north america. | climate differences across latitude can result in seasonal constraints and selection on life-history characters. because aedes albopictus (skuse) invaded north america in the mid-1980s, it has spread across a range of ≈14° latitude and populations in the north experience complete adult mortality because of cold winter temperatures that are absent in the south. life-table experiments were conducted to test for differences in the adult survival and reproductive schedules of ae. albopictus females ... | 0 | 22707762 |
| baylisascaris procyonis-associated meningoencephalitis in a previously healthy adult, california, usa. | after severe neurocognitive decline developed in an otherwise healthy 63-year-old man, brain magnetic resonance imaging showed eosinophilic meningoencephalitis and enhancing lesions. the patient tested positive for antibodies to baylisascaris spp. roundworms, was treated with albendazole and dexamethasone, and showed improvement after 3 months. baylisascariasis should be considered for all patients with eosinophilic meningitis. | 0 | 27434260 |
| assembly and release of infectious hepatitis c virus involving unusual organization of the secretory pathway. | to determine if calnexin (canx), rab1 and alpha-tubulin were involved in the production of hepatitis c virus (hcv) particles by baby hamster kidney-west nile virus (bhk-wnv) cells. | 0 | 27429716 |
| event-based surveillance during expo milan 2015: rationale, tools, procedures, and initial results. | more than 21 million participants attended expo milan from may to october 2015, making it one of the largest protracted mass gathering events in europe. given the expected national and international population movement and health security issues associated with this event, italy fully implemented, for the first time, an event-based surveillance (ebs) system focusing on naturally occurring infectious diseases and the monitoring of biological agents with potential for intentional release. the syst ... | 0 | 27314656 |
| roots, not parachutes: research collaborations combat outbreaks. | recent infectious disease epidemics illustrate how health systems failures anywhere can create disease vulnerabilities everywhere. we must therefore prioritize investments in health care infrastructure in outbreak-prone regions of the world. we describe how "rooted" research collaborations can establish capacity for pathogen surveillance and facilitate rapid outbreak responses. | 0 | 27368093 |
| plantibodies in human and animal health: a review. | antibodies are essential part of vertebrates' adaptive immune system; they can now be produced by transforming plants with antibody-coding genes from mammals/humans. although plants do not naturally make antibodies, the plant-derived antibodies (plantibodies) have been shown to function in the same way as mammalian antibodies. | 0 | 27605982 |
| cardiac myosin-th17 responses promote heart failure in human myocarditis. | in human myocarditis and its sequela dilated cardiomyopathy (dcm), the mechanisms and immune phenotype governing disease and subsequent heart failure are not known. here, we identified a th17 cell immunophenotype of human myocarditis/dcm with elevated cd4(+)il17(+) t cells and th17-promoting cytokines il-6, tgf-β, and il-23 as well as gm-csf-secreting cd4(+) t cells. the th17 phenotype was linked with the effects of cardiac myosin on cd14(+) monocytes, tlr2, and heart failure. persistent heart f ... | 0 | 27366791 |
| emerging arboviruses and public health challenges in brazil. | environmental modification by anthropogenic actions, disordered urban growth, globalization of international exchange and climate change are some factors that help the emergence and dissemination of human infectious diseases transmitted by vectors. this review discusses the recent entry of three arboviruses in brazil: chikungunya, west nile, and zika virus, focusing on the challenges for the country's public health. the brazilian population is exposed to infections caused by these three arboviru ... | 0 | 27355468 |
| long-distance rna-rna interactions in plant virus gene expression and replication. | the vast majority of plant and animal viruses have rna genomes. viral gene expression and replication are controlled by cis-acting elements in the viral genome, which have been viewed conventionally as localized structures. however, recent research has altered this perception and provided compelling evidence for cooperative activity involving distantly positioned rna elements. this chapter focuses on viral rna elements that interact across hundreds or thousands of intervening nucleotides to cont ... | 0 | 16704356 |
| guidelines for the assessment and acceptance of potential brain-dead organ donors. | organ transplantation is the only alternative for many patients with terminal diseases. the increasing disproportion between the high demand for organ transplants and the low rate of transplants actually performed is worrisome. some of the causes of this disproportion are errors in the identification of potential organ donors and in the determination of contraindications by the attending staff. therefore, the aim of the present document is to provide guidelines for intensive care multi-professio ... | 0 | 27737418 |
| fear of terrorism and preparedness in new york city 2 years after the attacks: implications for disaster planning and research. | to help improve disaster planning and research, we studied psychosocial predictors of terrorism fear and preparedness among new york city residents after the world trade center disaster (wtcd). | 0 | 17041297 |
| the biological actions of dehydroepiandrosterone involves multiple receptors. | dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. the previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. to date, activation of the peroxisome proliferators activated receptor alpha, pregnane x receptor, and estrogen receptor by dhea and its metabolites have been demonstrated. several membrane-associated receptor ... | 0 | 16684650 |
| use of a prospective space-time scan statistic to prioritize shigellosis case investigations in an urban jurisdiction. | a prospective space-time scan statistic was applied to chicago's 2002 shigellosis surveillance data to evaluate its utility in objectively describing clusters and assisting in the prioritization of investigations. | 0 | 16528945 |
| transfusion and risk of infection in canada: update 2006. | 0 | 18418483 | |
| detecting emerging diseases in farm animals through clinical observations. | predicting emerging diseases is among the most difficult challenges facing researchers and health managers. we present available approaches and tools to detect emerging diseases in animals based on clinical observations of farm animals by veterinarians. three information systems are described and discussed: veterinary practitioner aided disease surveillance in new zealand, the rapid syndrome validation project-animal in the united states, and "émergences" in france. these systems are based on sy ... | 0 | 16494743 |
| harnessing mother nature against your fellow humans. | 0 | 16308381 | |
| mechanisms of malignant glioma immune resistance and sources of immunosuppression. | high grade malignant gliomas are genetically unstable, heterogeneous and highly infiltrative; all characteristics that lend glioma cells superior advantages in resisting conventional therapies. unfortunately, the median survival time for patients with glioblastoma multiforme remains discouraging at 12-15 months from diagnosis. neuroimmunologists/oncologists have focused their research efforts to harness the power of the immune system to improve brain tumor patient survival. in the past 30 years, ... | 0 | 16810329 |
| a walk on the wild side--emerging wildlife diseases. | 0 | 16308357 | |
| veterinary public health. | 0 | 16308356 | |
| role of multisector partnerships in controlling emerging zoonotic diseases. | 0 | 22289146 | |
| illness perceptions among cardiac patients: relation to depressive symptomatology and sex. | this study examined cardiovascular disease (cvd) illness perceptions and how they relate to depressive symptomatology among women and men. | 0 | 16198188 |
| single-particle tracking demonstrates that actin coordinates the movement of the ebola virus matrix protein. | the ebola virus causes severe hemorrhagic fever and has a mortality rate that can be as high as 90%, yet no vaccines or approved therapeutics, to our knowledge, are available. to replicate and egress the infected host cell the ebola virus uses vp40, its major matrix protein to assemble at the inner leaflet of the plasma membrane. the assembly and budding of vp40 from the plasma membrane of host cells seem still poorly understood. we investigated the assembly and egress of vp40 at the plasma memb ... | 0 | 23199932 |
| nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus. | raised serum levels of interferon (ifn)-alpha have been observed in systemic lupus erythematosus (sle) patients, and these levels are correlated with both disease activity and severity. the origin of this ifn-alpha is still unclear, but increasing evidence suggests the critical involvement of activated plasmacytoid predendritic cells (pdcs). in sle patients, dna and rna viruses, as well as immune complexes (ics), that consist of autoantibodies specific to self-dna and rna protein particles can s ... | 0 | 16230478 |
| katrina, climate change and the poor. | 0 | 16217088 | |
| in katrina's wake. | 0 | 16393645 | |
| the tim and tam families of phosphatidylserine receptors mediate dengue virus entry. | dengue viruses (dvs) are responsible for the most medically relevant arboviral diseases. however, the molecular interactions mediating dv entry are poorly understood. we determined that tim and tam proteins, two receptor families that mediate the phosphatidylserine (ptdser)-dependent phagocytic removal of apoptotic cells, serve as dv entry factors. cells poorly susceptible to dv are robustly infected after ectopic expression of tim or tam receptors. conversely, dv infection of susceptible cells ... | 0 | 23084921 |
| emergence of toscana virus in the mediterranean area. | toscana virus (tosv) is an arthropod-borne virus, identified in 1971, from phlebotomus perniciosus and phlebotomus perfiliewi in central italy. tosv belongs to the phlebovirus genus within the bunyaviridae family. as other bunyaviruses, the genome of tosv consists of 3 segments (s for small, m for medium, and l for large) respectively encoding non structural and capsid proteins, envelope structural proteins, and the viral rna-dependant rna-polymerase. it is transmitted by sand flies. therefore i ... | 0 | 24175218 |