Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| surveillance for western equine encephalitis, st. louis encephalitis, and west nile viruses using reverse transcription loop-mediated isothermal amplification. | collection of mosquitoes and testing for vector-borne viruses is a key surveillance activity that directly influences the vector control efforts of public health agencies, including determining when and where to apply insecticides. vector control districts in california routinely monitor for three human pathogenic viruses including west nile virus (wnv), western equine encephalitis virus (weev), and st. louis encephalitis virus (slev). reverse transcription quantitative polymerase chain reaction ... | 2016 | 26807734 |
| exploring genetic variation in haplotypes of the filariasis vector culex quinquefasciatus (diptera: culicidae) through dna barcoding. | culex quinquefasciatus (diptera: culicidae) is a vector of many pathogens and parasites of humans, as well as domestic and wild animals. in urban and semi-urban asian countries, cx. quinquefasciatus is a main vector of nematodes causing lymphatic filariasis. in the african region, it vectors the rift valley fever virus, while in the usa it transmits west nile, st. louis encephalitis and western equine encephalitis virus. in this study, dna barcoding was used to explore the genetic variation of c ... | 2017 | 28126462 |
| susceptibility and lethality of western equine encephalitis virus in balb/c mice when infected by the aerosol route. | western equine encephalitis virus (weev) naturally cycles between mosquitos and birds or rodents, with a case fatality rate of up to 15% in humans during epizootic outbreaks. there are no medical countermeasures to treat weev infection, and accidental aerosol exposure increases the case fatality rate up to 40%. understanding the pathogenesis of infection is required to develop and assess medical countermeasures. this study describes the clinical and pathological findings of mice infected with we ... | 2017 | 28654007 |
| host-feeding patterns of culex stigmatosoma (diptera: culicidae) in southern california. | knowledge of the blood-feeding patterns exhibited by arthropod vectors is essential for understanding the complex dynamics of vector-borne disease transmission. some species of mosquitoes belonging to the genus culex have been implicated as having major roles in the transmission of arboviruses such as west nile virus, saint louis encephalitis virus, and western equine encephalitis virus. although the host-feeding patterns for many of these culex species are well studied, the host-feeding pattern ... | 2017 | 28968822 |
| discovery of a novel alphavirus related to eilat virus. | most alphaviruses are transmitted by arthropods and infect vertebrate hosts. an exception is eilat virus (eilv), the only described alphavirus with a host range restricted to insects. we established a new generic reverse transcription pcr assay for alphaviruses and tested 8860 tropical mosquitoes. we detected a novel alphavirus, tentatively named taï forest alphavirus (talv), in culex decens mosquitoes collected in ivory coast. the full genome was sequenced, and closest similarity was found to e ... | 2017 | 28206905 |
| potential sympatric vectors and mammalian hosts of venezuelan equine encephalitis virus in southern mexico. | arboviruses are important zoonotic agents with complex transmission cycles and are not well understood because they may involve many vectors and hosts. we studied sympatric wild mammals and hematophagous mosquitoes having the potential to act as hosts and vectors in two areas of southern mexico. mosquitoes, bats, and rodents were captured in calakmul (campeche) and montes azules (chiapas), between november 2010 and august 2011. spleen samples from 146 bats and 14 rodents were tested for molecula ... | 2017 | 28384059 |
| ablation of programmed -1 ribosomal frameshifting in venezuelan equine encephalitis virus results in attenuated neuropathogenicity. | the alphaviruses venezuelan equine encephalitis virus (veev), eastern equine encephalitis virus (eeev), and western equine encephalitis virus (weev) are arthropod-borne positive-strand rna viruses that are capable of causing acute and fatal encephalitis in many mammals, including humans. veev was weaponized during the cold war and is recognized as a select agent. currently, there are no fda-approved vaccines or therapeutics for these viruses. the spread of veev and other members of this family d ... | 2017 | 27852852 |
| serological evidence of widespread exposure of grenada fruit bats to chikungunya virus. | antibody detection against selected potentially zoonotic vector-borne alphaviruses and flaviviruses was conducted on sera from bats from all six parishes in grenada, west indies. sera were tested for (i) antibodies to flaviviruses west nile virus, st. louis encephalitis virus, ilhéus virus, bussuquara virus (bsqv), rio bravo virus and all four serotypes of dengue virus (denv) by plaque reduction neutralization test (prnt); (ii) antibodies to alphaviruses western equine encephalitis virus, venezu ... | 2018 | 29575672 |
| serological survey for select infectious agents in wild magellanic penguins (spheniscus magellanicus) in argentina, 1994-2008. | despite being the most numerous penguin species in south america, exposure of the magellanic penguin (spheniscus magellanicus) to pathogens has not yet been thoroughly assessed. we collected serum from 1,058 magellanic penguins at 10 breeding colonies along the entire latitudinal range of this species in argentina. the work spanned 10 breeding seasons over 15 yr (1994-2008). sera were tested for antibodies to select infectious agents. antibodies reacting against 16 pathogens were detected (serop ... | 2020 | 31237822 |
| comparative pathology study of venezuelan, eastern, and western equine encephalitis viruses in non-human primates. | venezuelan, eastern, and western equine encephalitis viruses (veev, eeev, and weev) are mosquito-borne viruses in the americas that cause central nervous system (cns) disease in humans and equids. in this study, we directly characterized the pathogenesis of veev, eeev, and weev in cynomolgus macaques following subcutaneous exposure because this route more closely mimics natural infection via mosquito transmission or by an accidental needle stick. our results highlight how eeev is significantly m ... | 2020 | 32755661 |
| serosurvey of eastern, western, and venezuelan equine encephalitis viruses in wild boars (sus scrofa), hunting dogs, and hunters of brazil. | a total of 102 free-range wild boars, 170 hunting dogs, and 49 hunters from 3 brazilian regions were sampled and tested for antibodies to eastern equine encephalitis virus (eeev), western equine encephalitis virus, and venezuelan equine encephalitis virus. three of the 102 (2.9%) wild boars were positive for antibodies against eeev by microplate serum neutralization test. based on our data, free-range wild boars from central-western brazil may be exposed to eeev, and further studies are needed t ... | 2020 | 32644885 |
| "submergence" of western equine encephalitis virus: evidence of positive selection argues against genetic drift and fitness reductions. | understanding the circumstances under which arboviruses emerge is critical for the development of targeted control and prevention strategies. this is highlighted by the emergence of chikungunya and zika viruses in the new world. however, to comprehensively understand the ways in which viruses emerge and persist, factors influencing reductions in virus activity must also be understood. western equine encephalitis virus (weev), which declined during the late 20th century in apparent enzootic circu ... | 2020 | 32027727 |
| stabilization of a broadly neutralizing anti-chikungunya virus single domain antibody. | a single domain antibody (clone cc3) previously found to neutralize a vaccine strain of the chikungunya virus (prnt50 = 2. 5 ng/ml) was found to be broadly neutralizing. clone cc3 is not only able to neutralize a wild-type (wt) strain of chikungunya virus (chikv), but also neutralizes wt strains of mayaro virus (mayv) and ross river virus (rrv); both arthralgic, old world alphaviruses. interestingly, cc3 also demonstrated a degree of neutralizing activity against the new world alphavirus, venezu ... | 2021 | 33585527 |